-- dump date 20120504_134748 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1075106000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1075106000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106000003 Walker A motif; other site 1075106000004 ATP binding site [chemical binding]; other site 1075106000005 Walker B motif; other site 1075106000006 arginine finger; other site 1075106000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1075106000008 DnaA box-binding interface [nucleotide binding]; other site 1075106000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1075106000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1075106000011 putative DNA binding surface [nucleotide binding]; other site 1075106000012 dimer interface [polypeptide binding]; other site 1075106000013 beta-clamp/clamp loader binding surface; other site 1075106000014 beta-clamp/translesion DNA polymerase binding surface; other site 1075106000015 recombination protein F; Reviewed; Region: recF; PRK00064 1075106000016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000017 Walker A/P-loop; other site 1075106000018 ATP binding site [chemical binding]; other site 1075106000019 Q-loop/lid; other site 1075106000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000021 ABC transporter signature motif; other site 1075106000022 Walker B; other site 1075106000023 D-loop; other site 1075106000024 H-loop/switch region; other site 1075106000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1075106000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1075106000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106000028 Mg2+ binding site [ion binding]; other site 1075106000029 G-X-G motif; other site 1075106000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1075106000031 anchoring element; other site 1075106000032 dimer interface [polypeptide binding]; other site 1075106000033 ATP binding site [chemical binding]; other site 1075106000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1075106000035 active site 1075106000036 putative metal-binding site [ion binding]; other site 1075106000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1075106000038 DNA gyrase subunit A; Validated; Region: PRK05560 1075106000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1075106000040 CAP-like domain; other site 1075106000041 active site 1075106000042 primary dimer interface [polypeptide binding]; other site 1075106000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1075106000050 VanZ like family; Region: VanZ; cl01971 1075106000051 Haemolysin-III related; Region: HlyIII; cl03831 1075106000052 glutamate dehydrogenase; Provisional; Region: PRK09414 1075106000053 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1075106000054 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1075106000055 NAD(P) binding site [chemical binding]; other site 1075106000056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000057 putative substrate translocation pore; other site 1075106000058 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 1075106000059 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1075106000060 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1075106000061 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 1075106000062 Protein of unknown function DUF45; Region: DUF45; cl00636 1075106000063 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1075106000064 Helix-turn-helix domains; Region: HTH; cl00088 1075106000065 Helix-turn-helix domains; Region: HTH; cl00088 1075106000066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000067 Walker A/P-loop; other site 1075106000068 ATP binding site [chemical binding]; other site 1075106000069 Q-loop/lid; other site 1075106000070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000071 ABC transporter signature motif; other site 1075106000072 Walker B; other site 1075106000073 D-loop; other site 1075106000074 H-loop/switch region; other site 1075106000075 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000076 Walker A/P-loop; other site 1075106000077 ATP binding site [chemical binding]; other site 1075106000078 Q-loop/lid; other site 1075106000079 ABC transporter signature motif; other site 1075106000080 Walker B; other site 1075106000081 D-loop; other site 1075106000082 H-loop/switch region; other site 1075106000083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106000084 S-adenosylmethionine binding site [chemical binding]; other site 1075106000085 hypothetical protein; Provisional; Region: PRK08317 1075106000086 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1075106000087 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1075106000088 homodimer interface [polypeptide binding]; other site 1075106000089 chemical substrate binding site [chemical binding]; other site 1075106000090 oligomer interface [polypeptide binding]; other site 1075106000091 metal binding site [ion binding]; metal-binding site 1075106000092 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1075106000093 GIY-YIG motif/motif A; other site 1075106000094 active site 1075106000095 catalytic site [active] 1075106000096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106000097 DNA binding site [nucleotide binding] 1075106000098 substrate interaction site [chemical binding]; other site 1075106000099 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1075106000100 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1075106000101 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1075106000102 PemK-like protein; Region: PemK; cl00995 1075106000103 Helix-turn-helix domains; Region: HTH; cl00088 1075106000104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1075106000105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1075106000106 catalytic tetrad [active] 1075106000107 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000108 active site 1075106000109 catalytic tetrad [active] 1075106000110 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1075106000111 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1075106000112 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1075106000113 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106000114 substrate binding site [chemical binding]; other site 1075106000115 Aminoglycoside 3'-phosphotransferase 1075106000116 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1075106000117 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106000118 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106000119 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1075106000120 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1075106000121 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1075106000122 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 1075106000123 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1075106000124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000125 putative substrate translocation pore; other site 1075106000126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106000127 Helix-turn-helix domains; Region: HTH; cl00088 1075106000128 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1075106000129 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1075106000130 dimerization interface [polypeptide binding]; other site 1075106000131 DPS ferroxidase diiron center [ion binding]; other site 1075106000132 ion pore; other site 1075106000133 Domain of unknown function DUF21; Region: DUF21; pfam01595 1075106000134 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1075106000135 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1075106000136 Transporter associated domain; Region: CorC_HlyC; cl08393 1075106000137 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1075106000138 active site clefts [active] 1075106000139 zinc binding site [ion binding]; other site 1075106000140 dimer interface [polypeptide binding]; other site 1075106000141 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1075106000142 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106000143 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106000144 DNA binding site [nucleotide binding] 1075106000145 domain linker motif; other site 1075106000146 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1075106000147 ligand binding site [chemical binding]; other site 1075106000148 dimerization interface (open form) [polypeptide binding]; other site 1075106000149 dimerization interface (closed form) [polypeptide binding]; other site 1075106000150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000151 Walker A/P-loop; other site 1075106000152 ATP binding site [chemical binding]; other site 1075106000153 ABC transporter; Region: ABC_tran; pfam00005 1075106000154 Q-loop/lid; other site 1075106000155 ABC transporter signature motif; other site 1075106000156 Walker B; other site 1075106000157 D-loop; other site 1075106000158 H-loop/switch region; other site 1075106000159 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106000160 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106000161 DNA binding site [nucleotide binding] 1075106000162 domain linker motif; other site 1075106000163 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106000164 ligand binding site [chemical binding]; other site 1075106000165 dimerization interface [polypeptide binding]; other site 1075106000166 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1075106000167 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1075106000168 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1075106000169 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1075106000170 putative N- and C-terminal domain interface [polypeptide binding]; other site 1075106000171 putative active site [active] 1075106000172 putative MgATP binding site [chemical binding]; other site 1075106000173 catalytic site [active] 1075106000174 metal binding site [ion binding]; metal-binding site 1075106000175 putative carbohydrate binding site [chemical binding]; other site 1075106000176 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1075106000177 intersubunit interface [polypeptide binding]; other site 1075106000178 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1075106000179 active site 1075106000180 Zn2+ binding site [ion binding]; other site 1075106000181 L-arabinose isomerase; Provisional; Region: PRK02929 1075106000182 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1075106000183 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1075106000184 trimer interface [polypeptide binding]; other site 1075106000185 substrate binding site [chemical binding]; other site 1075106000186 Mn binding site [ion binding]; other site 1075106000187 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000188 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106000189 active site 1075106000190 catalytic tetrad [active] 1075106000191 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1075106000192 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 1075106000193 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1075106000194 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1075106000195 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1075106000196 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106000197 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106000198 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1075106000199 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1075106000200 active site 1075106000201 HIGH motif; other site 1075106000202 dimer interface [polypeptide binding]; other site 1075106000203 KMSKS motif; other site 1075106000204 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1075106000205 homodimer interface [polypeptide binding]; other site 1075106000206 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1075106000207 active site pocket [active] 1075106000208 Rhomboid family; Region: Rhomboid; cl11446 1075106000209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106000210 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 1075106000211 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1075106000212 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1075106000213 active site 1075106000214 catalytic site [active] 1075106000215 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1075106000216 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1075106000217 glutamine binding [chemical binding]; other site 1075106000218 catalytic triad [active] 1075106000219 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106000220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106000221 active site 1075106000222 ATP binding site [chemical binding]; other site 1075106000223 substrate binding site [chemical binding]; other site 1075106000224 activation loop (A-loop); other site 1075106000225 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106000226 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106000227 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106000228 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106000229 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106000230 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1075106000231 active site 1075106000232 ATP binding site [chemical binding]; other site 1075106000233 substrate binding site [chemical binding]; other site 1075106000234 activation loop (A-loop); other site 1075106000235 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1075106000236 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1075106000237 Protein of unknown function (DUF4106); Region: DUF4106; pfam13388 1075106000238 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1075106000239 active site 1075106000240 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106000241 phosphopeptide binding site; other site 1075106000242 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1075106000243 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106000244 phosphopeptide binding site; other site 1075106000245 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1075106000246 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1075106000247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106000248 EamA-like transporter family; Region: EamA; cl01037 1075106000249 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1075106000250 EamA-like transporter family; Region: EamA; cl01037 1075106000251 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106000252 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1075106000253 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 1075106000254 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1075106000255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106000256 S-adenosylmethionine binding site [chemical binding]; other site 1075106000257 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1075106000258 ferredoxin-NADP+ reductase; Region: PLN02852 1075106000259 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1075106000260 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106000261 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106000262 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 1075106000263 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1075106000264 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1075106000265 protein binding site [polypeptide binding]; other site 1075106000266 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1075106000267 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106000268 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1075106000269 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1075106000270 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1075106000271 Peptidase family M48; Region: Peptidase_M48; cl12018 1075106000272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1075106000273 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1075106000274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106000276 putative substrate translocation pore; other site 1075106000277 RelB antitoxin; Region: RelB; cl01171 1075106000278 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1075106000279 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1075106000280 DNA binding site [nucleotide binding] 1075106000281 active site 1075106000282 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1075106000283 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1075106000284 Cupin domain; Region: Cupin_2; cl09118 1075106000285 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1075106000286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1075106000287 Helix-turn-helix domains; Region: HTH; cl00088 1075106000288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1075106000289 dimerization interface [polypeptide binding]; other site 1075106000290 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1075106000291 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000292 active site 1075106000293 catalytic tetrad [active] 1075106000294 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1075106000295 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1075106000296 FAD binding pocket [chemical binding]; other site 1075106000297 conserved FAD binding motif [chemical binding]; other site 1075106000298 phosphate binding motif [ion binding]; other site 1075106000299 beta-alpha-beta structure motif; other site 1075106000300 NAD binding pocket [chemical binding]; other site 1075106000301 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1075106000302 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1075106000303 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1075106000304 DNA binding residues [nucleotide binding] 1075106000305 putative dimer interface [polypeptide binding]; other site 1075106000306 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1075106000307 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1075106000308 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1075106000309 NAD(P) binding site [chemical binding]; other site 1075106000310 putative active site [active] 1075106000311 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1075106000312 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1075106000313 catalytic Zn binding site [ion binding]; other site 1075106000314 NAD(P) binding site [chemical binding]; other site 1075106000315 structural Zn binding site [ion binding]; other site 1075106000316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1075106000317 Helix-turn-helix domains; Region: HTH; cl00088 1075106000318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1075106000319 dimerization interface [polypeptide binding]; other site 1075106000320 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1075106000321 NodB motif; other site 1075106000322 active site 1075106000323 catalytic site [active] 1075106000324 metal binding site [ion binding]; metal-binding site 1075106000325 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1075106000326 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1075106000327 active site 1075106000328 intersubunit interface [polypeptide binding]; other site 1075106000329 zinc binding site [ion binding]; other site 1075106000330 Na+ binding site [ion binding]; other site 1075106000331 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1075106000332 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1075106000333 GDP-binding site [chemical binding]; other site 1075106000334 ACT binding site; other site 1075106000335 IMP binding site; other site 1075106000336 CrcB-like protein; Region: CRCB; cl09114 1075106000337 CrcB-like protein; Region: CRCB; cl09114 1075106000338 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1075106000339 TM-ABC transporter signature motif; other site 1075106000340 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1075106000341 TM-ABC transporter signature motif; other site 1075106000342 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1075106000343 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1075106000344 Walker A/P-loop; other site 1075106000345 ATP binding site [chemical binding]; other site 1075106000346 Q-loop/lid; other site 1075106000347 ABC transporter signature motif; other site 1075106000348 Walker B; other site 1075106000349 D-loop; other site 1075106000350 H-loop/switch region; other site 1075106000351 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1075106000352 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1075106000353 Walker A/P-loop; other site 1075106000354 ATP binding site [chemical binding]; other site 1075106000355 Q-loop/lid; other site 1075106000356 ABC transporter signature motif; other site 1075106000357 Walker B; other site 1075106000358 D-loop; other site 1075106000359 H-loop/switch region; other site 1075106000360 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1075106000361 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1075106000362 ligand binding site [chemical binding]; other site 1075106000363 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106000364 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106000365 DNA binding site [nucleotide binding] 1075106000366 domain linker motif; other site 1075106000367 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1075106000368 sucrose phosphorylase; Provisional; Region: PRK13840 1075106000369 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1075106000370 active site 1075106000371 homodimer interface [polypeptide binding]; other site 1075106000372 catalytic site [active] 1075106000373 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 1075106000374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106000376 putative substrate translocation pore; other site 1075106000377 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1075106000378 ligand binding site [chemical binding]; other site 1075106000379 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1075106000380 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106000381 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1075106000382 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 1075106000383 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1075106000384 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106000385 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1075106000386 metabolite-proton symporter; Region: 2A0106; TIGR00883 1075106000387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000388 putative substrate translocation pore; other site 1075106000389 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1075106000390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106000391 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1075106000392 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1075106000393 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1075106000394 active site 1075106000395 catalytic triad [active] 1075106000396 oxyanion hole [active] 1075106000397 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1075106000398 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106000399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106000400 DNA binding site [nucleotide binding] 1075106000401 domain linker motif; other site 1075106000402 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106000403 ligand binding site [chemical binding]; other site 1075106000404 dimerization interface [polypeptide binding]; other site 1075106000405 Protein of unknown function, DUF624; Region: DUF624; cl02369 1075106000406 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1075106000407 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 1075106000408 putative active cleft [active] 1075106000409 dimerization interface [polypeptide binding]; other site 1075106000410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000411 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1075106000412 Walker A/P-loop; other site 1075106000413 ATP binding site [chemical binding]; other site 1075106000414 Q-loop/lid; other site 1075106000415 ABC transporter signature motif; other site 1075106000416 Walker B; other site 1075106000417 D-loop; other site 1075106000418 H-loop/switch region; other site 1075106000419 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1075106000420 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1075106000421 Spore germination protein; Region: Spore_permease; cl15802 1075106000422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106000423 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1075106000424 Walker A/P-loop; other site 1075106000425 ATP binding site [chemical binding]; other site 1075106000426 Q-loop/lid; other site 1075106000427 ABC transporter signature motif; other site 1075106000428 Walker B; other site 1075106000429 D-loop; other site 1075106000430 H-loop/switch region; other site 1075106000431 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106000432 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1075106000433 FtsX-like permease family; Region: FtsX; cl15850 1075106000434 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1075106000435 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106000436 FtsX-like permease family; Region: FtsX; cl15850 1075106000437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000438 ABC transporter signature motif; other site 1075106000439 Walker B; other site 1075106000440 D-loop; other site 1075106000441 H-loop/switch region; other site 1075106000442 Helix-turn-helix domains; Region: HTH; cl00088 1075106000443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106000444 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1075106000445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000446 Walker A/P-loop; other site 1075106000447 ATP binding site [chemical binding]; other site 1075106000448 Q-loop/lid; other site 1075106000449 ABC transporter signature motif; other site 1075106000450 Walker B; other site 1075106000451 D-loop; other site 1075106000452 H-loop/switch region; other site 1075106000453 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106000454 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1075106000455 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1075106000456 Walker A/P-loop; other site 1075106000457 ATP binding site [chemical binding]; other site 1075106000458 Q-loop/lid; other site 1075106000459 ABC transporter signature motif; other site 1075106000460 Walker B; other site 1075106000461 D-loop; other site 1075106000462 H-loop/switch region; other site 1075106000463 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1075106000464 NodB motif; other site 1075106000465 active site 1075106000466 catalytic site [active] 1075106000467 metal binding site [ion binding]; metal-binding site 1075106000468 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1075106000469 active site 1075106000470 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1075106000471 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1075106000472 active site 1075106000473 substrate binding site [chemical binding]; other site 1075106000474 trimer interface [polypeptide binding]; other site 1075106000475 CoA binding site [chemical binding]; other site 1075106000476 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1075106000477 ligand binding site [chemical binding]; other site 1075106000478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106000479 Helix-turn-helix domains; Region: HTH; cl00088 1075106000480 Predicted membrane protein [Function unknown]; Region: COG1511 1075106000481 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1075106000482 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1075106000483 Predicted membrane protein [Function unknown]; Region: COG1511 1075106000484 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1075106000485 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1075106000486 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1075106000487 Cobalt transport protein; Region: CbiQ; cl00463 1075106000488 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106000489 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106000490 Walker A/P-loop; other site 1075106000491 ATP binding site [chemical binding]; other site 1075106000492 Q-loop/lid; other site 1075106000493 ABC transporter signature motif; other site 1075106000494 Walker B; other site 1075106000495 D-loop; other site 1075106000496 H-loop/switch region; other site 1075106000497 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 1075106000498 Walker A/P-loop; other site 1075106000499 ATP binding site [chemical binding]; other site 1075106000500 Q-loop/lid; other site 1075106000501 ABC transporter signature motif; other site 1075106000502 Walker B; other site 1075106000503 D-loop; other site 1075106000504 H-loop/switch region; other site 1075106000505 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1075106000506 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1075106000507 intersubunit interface [polypeptide binding]; other site 1075106000508 YodA lipocalin-like domain; Region: YodA; cl01365 1075106000509 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1075106000510 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1075106000511 active site 1075106000512 nucleophile elbow; other site 1075106000513 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1075106000514 Peptidase family C69; Region: Peptidase_C69; pfam03577 1075106000515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106000516 Helix-turn-helix domains; Region: HTH; cl00088 1075106000517 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1075106000518 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1075106000519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000520 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1075106000521 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1075106000522 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1075106000523 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1075106000524 metal binding triad; other site 1075106000525 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1075106000526 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1075106000527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1075106000528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1075106000529 sequence-specific DNA binding site [nucleotide binding]; other site 1075106000530 salt bridge; other site 1075106000531 replicative DNA helicase; Region: DnaB; TIGR00665 1075106000532 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1075106000533 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1075106000534 Walker A motif; other site 1075106000535 ATP binding site [chemical binding]; other site 1075106000536 Walker B motif; other site 1075106000537 DNA binding loops [nucleotide binding] 1075106000538 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106000539 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1075106000540 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1075106000541 catalytic triad [active] 1075106000542 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1075106000543 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1075106000544 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106000545 ATP binding site [chemical binding]; other site 1075106000546 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1075106000547 active site 1075106000548 catalytic site [active] 1075106000549 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106000550 active site 1075106000551 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1075106000552 active site 1075106000553 Ap6A binding site [chemical binding]; other site 1075106000554 nudix motif; other site 1075106000555 metal binding site [ion binding]; metal-binding site 1075106000556 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1075106000557 polyphosphate kinase; Provisional; Region: PRK05443 1075106000558 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1075106000559 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1075106000560 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1075106000561 putative domain interface [polypeptide binding]; other site 1075106000562 putative active site [active] 1075106000563 catalytic site [active] 1075106000564 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1075106000565 putative domain interface [polypeptide binding]; other site 1075106000566 putative active site [active] 1075106000567 catalytic site [active] 1075106000568 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1075106000569 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1075106000570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000571 Walker B motif; other site 1075106000572 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1075106000573 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1075106000574 TadE-like protein; Region: TadE; cl10688 1075106000575 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1075106000576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106000577 Walker A motif; other site 1075106000578 ATP binding site [chemical binding]; other site 1075106000579 Walker B motif; other site 1075106000580 arginine finger; other site 1075106000581 recombination protein RecR; Reviewed; Region: recR; PRK00076 1075106000582 RecR protein; Region: RecR; pfam02132 1075106000583 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1075106000584 putative active site [active] 1075106000585 putative metal-binding site [ion binding]; other site 1075106000586 tetramer interface [polypeptide binding]; other site 1075106000587 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1075106000588 putative nucleotide binding site [chemical binding]; other site 1075106000589 putative catalytic residues [active] 1075106000590 putative Mg ion binding site [ion binding]; other site 1075106000591 putative aspartate binding site [chemical binding]; other site 1075106000592 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1075106000593 putative allosteric regulatory site; other site 1075106000594 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1075106000595 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1075106000596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106000597 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1075106000598 2-isopropylmalate synthase; Validated; Region: PRK03739 1075106000599 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1075106000600 active site 1075106000601 catalytic residues [active] 1075106000602 metal binding site [ion binding]; metal-binding site 1075106000603 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1075106000604 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1075106000605 Transglycosylase; Region: Transgly; cl07896 1075106000606 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1075106000607 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1075106000608 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1075106000609 active site 1075106000610 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1075106000611 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1075106000612 active site 1075106000613 interdomain interaction site; other site 1075106000614 putative metal-binding site [ion binding]; other site 1075106000615 nucleotide binding site [chemical binding]; other site 1075106000616 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1075106000617 domain I; other site 1075106000618 phosphate binding site [ion binding]; other site 1075106000619 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1075106000620 domain II; other site 1075106000621 domain III; other site 1075106000622 nucleotide binding site [chemical binding]; other site 1075106000623 DNA binding groove [nucleotide binding] 1075106000624 catalytic site [active] 1075106000625 domain IV; other site 1075106000626 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1075106000627 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1075106000628 thymidylate kinase; Validated; Region: tmk; PRK00698 1075106000629 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1075106000630 TMP-binding site; other site 1075106000631 ATP-binding site [chemical binding]; other site 1075106000632 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1075106000633 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000634 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1075106000635 substrate binding site [chemical binding]; other site 1075106000636 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1075106000637 Peptidase family C69; Region: Peptidase_C69; pfam03577 1075106000638 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1075106000639 Peptidase family C69; Region: Peptidase_C69; pfam03577 1075106000640 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000641 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1075106000642 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 1075106000643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106000644 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 1075106000645 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1075106000646 putative active site [active] 1075106000647 GtrA-like protein; Region: GtrA; cl00971 1075106000648 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106000649 catalytic core [active] 1075106000650 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1075106000651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000652 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106000653 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106000654 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1075106000655 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1075106000656 active site 1075106000657 HIGH motif; other site 1075106000658 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1075106000659 active site 1075106000660 KMSKS motif; other site 1075106000661 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1075106000662 putative active site [active] 1075106000663 putative metal binding site [ion binding]; other site 1075106000664 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1075106000665 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1075106000666 Helix-turn-helix domains; Region: HTH; cl00088 1075106000667 Bacterial transcriptional regulator; Region: IclR; pfam01614 1075106000668 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1075106000669 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1075106000670 substrate binding site [chemical binding]; other site 1075106000671 ligand binding site [chemical binding]; other site 1075106000672 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1075106000673 substrate binding site [chemical binding]; other site 1075106000674 AsnC family; Region: AsnC_trans_reg; pfam01037 1075106000675 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1075106000676 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1075106000677 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1075106000678 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1075106000679 hinge; other site 1075106000680 active site 1075106000681 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1075106000682 putative acyl-acceptor binding pocket; other site 1075106000683 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1075106000684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106000685 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1075106000686 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1075106000687 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1075106000688 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106000689 DNA translocase FtsK; Provisional; Region: PRK10263 1075106000690 CAAX protease self-immunity; Region: Abi; cl00558 1075106000691 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1075106000692 Helix-turn-helix domains; Region: HTH; cl00088 1075106000693 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1075106000694 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741 1075106000695 nucleophilic elbow; other site 1075106000696 catalytic triad; other site 1075106000697 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1075106000698 Predicted membrane protein [Function unknown]; Region: COG4905 1075106000699 aspartate aminotransferase; Provisional; Region: PRK06836 1075106000700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106000701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106000702 homodimer interface [polypeptide binding]; other site 1075106000703 catalytic residue [active] 1075106000704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1075106000705 binding surface 1075106000706 TPR motif; other site 1075106000707 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1075106000708 substrate binding site [chemical binding]; other site 1075106000709 ATP binding site [chemical binding]; other site 1075106000710 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1075106000711 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1075106000712 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1075106000713 ssDNA binding site; other site 1075106000714 generic binding surface II; other site 1075106000715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106000716 ATP binding site [chemical binding]; other site 1075106000717 putative Mg++ binding site [ion binding]; other site 1075106000718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106000719 nucleotide binding region [chemical binding]; other site 1075106000720 ATP-binding site [chemical binding]; other site 1075106000721 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1075106000722 metal ion-dependent adhesion site (MIDAS); other site 1075106000723 T surface-antigen of pili; Region: FctA; cl16948 1075106000724 T surface-antigen of pili; Region: FctA; cl16948 1075106000725 T surface-antigen of pili; Region: FctA; cl16948 1075106000726 T surface-antigen of pili; Region: FctA; cl16948 1075106000727 T surface-antigen of pili; Region: FctA; cl16948 1075106000728 T surface-antigen of pili; Region: FctA; cl16948 1075106000729 T surface-antigen of pili; Region: FctA; cl16948 1075106000730 T surface-antigen of pili; Region: FctA; cl16948 1075106000731 T surface-antigen of pili; Region: FctA; cl16948 1075106000732 T surface-antigen of pili; Region: FctA; cl16948 1075106000733 T surface-antigen of pili; Region: FctA; cl16948 1075106000734 T surface-antigen of pili; Region: FctA; cl16948 1075106000735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106000736 S-adenosylmethionine binding site [chemical binding]; other site 1075106000737 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1075106000738 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1075106000739 RimM N-terminal domain; Region: RimM; pfam01782 1075106000740 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1075106000741 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1075106000742 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1075106000743 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1075106000744 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1075106000745 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 1075106000746 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 1075106000747 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1075106000748 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1075106000749 putative catalytic site [active] 1075106000750 putative phosphate binding site [ion binding]; other site 1075106000751 putative metal binding site [ion binding]; other site 1075106000752 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1075106000753 Cation efflux family; Region: Cation_efflux; cl00316 1075106000754 signal recognition particle protein; Provisional; Region: PRK10867 1075106000755 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1075106000756 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1075106000757 P loop; other site 1075106000758 GTP binding site [chemical binding]; other site 1075106000759 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1075106000760 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1075106000761 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106000762 active site 1075106000763 HIGH motif; other site 1075106000764 nucleotide binding site [chemical binding]; other site 1075106000765 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1075106000766 KMSKS motif; other site 1075106000767 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1075106000768 tRNA binding surface [nucleotide binding]; other site 1075106000769 anticodon binding site; other site 1075106000770 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1075106000771 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106000772 ABC transporter; Region: ABC_tran_2; pfam12848 1075106000773 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1075106000774 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1075106000775 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1075106000776 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1075106000777 catalytic triad [active] 1075106000778 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1075106000779 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1075106000780 putative valine binding site [chemical binding]; other site 1075106000781 dimer interface [polypeptide binding]; other site 1075106000782 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1075106000783 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1075106000784 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1075106000785 PYR/PP interface [polypeptide binding]; other site 1075106000786 dimer interface [polypeptide binding]; other site 1075106000787 TPP binding site [chemical binding]; other site 1075106000788 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1075106000789 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1075106000790 TPP-binding site [chemical binding]; other site 1075106000791 dimer interface [polypeptide binding]; other site 1075106000792 ribonuclease III; Reviewed; Region: rnc; PRK00102 1075106000793 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1075106000794 dimerization interface [polypeptide binding]; other site 1075106000795 active site 1075106000796 metal binding site [ion binding]; metal-binding site 1075106000797 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1075106000798 dsRNA binding site [nucleotide binding]; other site 1075106000799 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1075106000800 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1075106000801 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1075106000802 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1075106000803 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1075106000804 active site 1075106000805 (T/H)XGH motif; other site 1075106000806 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1075106000807 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1075106000808 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000809 active site 1075106000810 catalytic tetrad [active] 1075106000811 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1075106000812 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1075106000813 active site 1075106000814 ribonuclease PH; Reviewed; Region: rph; PRK00173 1075106000815 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1075106000816 hexamer interface [polypeptide binding]; other site 1075106000817 active site 1075106000818 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1075106000819 active site 1075106000820 dimerization interface [polypeptide binding]; other site 1075106000821 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106000822 Membrane transport protein; Region: Mem_trans; cl09117 1075106000823 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1075106000824 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1075106000825 Substrate binding site; other site 1075106000826 Cupin domain; Region: Cupin_2; cl09118 1075106000827 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1075106000828 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1075106000829 active site 1075106000830 dimer interface [polypeptide binding]; other site 1075106000831 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1075106000832 dimer interface [polypeptide binding]; other site 1075106000833 active site 1075106000834 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1075106000835 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1075106000836 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1075106000837 Catalytic site [active] 1075106000838 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1075106000839 RNA/DNA hybrid binding site [nucleotide binding]; other site 1075106000840 active site 1075106000841 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1075106000842 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1075106000843 Walker A/P-loop; other site 1075106000844 ATP binding site [chemical binding]; other site 1075106000845 Q-loop/lid; other site 1075106000846 ABC transporter signature motif; other site 1075106000847 Walker B; other site 1075106000848 D-loop; other site 1075106000849 H-loop/switch region; other site 1075106000850 FtsX-like permease family; Region: FtsX; cl15850 1075106000851 Membrane transport protein; Region: Mem_trans; cl09117 1075106000852 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 1075106000853 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1075106000854 metal binding site [ion binding]; metal-binding site 1075106000855 putative dimer interface [polypeptide binding]; other site 1075106000856 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1075106000857 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1075106000858 homodimer interface [polypeptide binding]; other site 1075106000859 oligonucleotide binding site [chemical binding]; other site 1075106000860 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1075106000861 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1075106000862 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1075106000863 GTP1/OBG; Region: GTP1_OBG; pfam01018 1075106000864 Obg GTPase; Region: Obg; cd01898 1075106000865 G1 box; other site 1075106000866 GTP/Mg2+ binding site [chemical binding]; other site 1075106000867 Switch I region; other site 1075106000868 G2 box; other site 1075106000869 G3 box; other site 1075106000870 Switch II region; other site 1075106000871 G4 box; other site 1075106000872 G5 box; other site 1075106000873 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 1075106000874 gamma-glutamyl kinase; Provisional; Region: PRK05429 1075106000875 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1075106000876 nucleotide binding site [chemical binding]; other site 1075106000877 homotetrameric interface [polypeptide binding]; other site 1075106000878 putative phosphate binding site [ion binding]; other site 1075106000879 putative allosteric binding site; other site 1075106000880 PUA domain; Region: PUA; cl00607 1075106000881 aspartate aminotransferase; Provisional; Region: PRK05764 1075106000882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106000883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106000884 homodimer interface [polypeptide binding]; other site 1075106000885 catalytic residue [active] 1075106000886 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1075106000887 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1075106000888 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1075106000889 putative homodimer interface [polypeptide binding]; other site 1075106000890 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1075106000891 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1075106000892 23S rRNA interface [nucleotide binding]; other site 1075106000893 L7/L12 interface [polypeptide binding]; other site 1075106000894 putative thiostrepton binding site; other site 1075106000895 L25 interface [polypeptide binding]; other site 1075106000896 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1075106000897 mRNA/rRNA interface [nucleotide binding]; other site 1075106000898 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1075106000899 Helix-turn-helix domains; Region: HTH; cl00088 1075106000900 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1075106000901 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1075106000902 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1075106000903 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1075106000904 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1075106000905 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106000906 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1075106000907 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1075106000908 carboxyltransferase (CT) interaction site; other site 1075106000909 biotinylation site [posttranslational modification]; other site 1075106000910 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1075106000911 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1075106000912 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1075106000913 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1075106000914 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1075106000915 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1075106000916 FMN binding site [chemical binding]; other site 1075106000917 substrate binding site [chemical binding]; other site 1075106000918 putative catalytic residue [active] 1075106000919 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1075106000920 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1075106000921 putative active site [active] 1075106000922 putative catalytic site [active] 1075106000923 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1075106000924 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1075106000925 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1075106000926 putative NAD(P) binding site [chemical binding]; other site 1075106000927 active site 1075106000928 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 1075106000929 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1075106000930 active site 1075106000931 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1075106000932 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1075106000933 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1075106000934 NAD binding site [chemical binding]; other site 1075106000935 dimer interface [polypeptide binding]; other site 1075106000936 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106000937 substrate binding site [chemical binding]; other site 1075106000938 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1075106000939 16S/18S rRNA binding site [nucleotide binding]; other site 1075106000940 S13e-L30e interaction site [polypeptide binding]; other site 1075106000941 25S rRNA binding site [nucleotide binding]; other site 1075106000942 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1075106000943 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1075106000944 oligomer interface [polypeptide binding]; other site 1075106000945 RNA binding site [nucleotide binding]; other site 1075106000946 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1075106000947 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1075106000948 RNase E interface [polypeptide binding]; other site 1075106000949 trimer interface [polypeptide binding]; other site 1075106000950 active site 1075106000951 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1075106000952 putative nucleic acid binding region [nucleotide binding]; other site 1075106000953 G-X-X-G motif; other site 1075106000954 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1075106000955 RNA binding site [nucleotide binding]; other site 1075106000956 domain interface; other site 1075106000957 LemA family; Region: LemA; cl00742 1075106000958 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1075106000959 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1075106000960 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1075106000961 dimer interface [polypeptide binding]; other site 1075106000962 putative radical transfer pathway; other site 1075106000963 diiron center [ion binding]; other site 1075106000964 tyrosyl radical; other site 1075106000965 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1075106000966 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1075106000967 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1075106000968 active site 1075106000969 dimer interface [polypeptide binding]; other site 1075106000970 catalytic residues [active] 1075106000971 effector binding site; other site 1075106000972 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1075106000973 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1075106000974 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1075106000975 catalytic residues [active] 1075106000976 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000977 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106000978 active site 1075106000979 catalytic tetrad [active] 1075106000980 Peptidase family U32; Region: Peptidase_U32; cl03113 1075106000981 putative protease; Provisional; Region: PRK15452 1075106000982 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1075106000983 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1075106000984 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1075106000985 substrate binding site; other site 1075106000986 dimer interface; other site 1075106000987 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1075106000988 putative substrate binding pocket [chemical binding]; other site 1075106000989 AC domain interface; other site 1075106000990 catalytic triad [active] 1075106000991 AB domain interface; other site 1075106000992 interchain disulfide; other site 1075106000993 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1075106000994 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1075106000995 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1075106000996 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1075106000997 trimer interface [polypeptide binding]; other site 1075106000998 active site 1075106000999 G bulge; other site 1075106001000 NeuB family; Region: NeuB; cl00496 1075106001001 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1075106001002 OpgC protein; Region: OpgC_C; cl00792 1075106001003 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1075106001004 catalytic triad [active] 1075106001005 catalytic triad [active] 1075106001006 oxyanion hole [active] 1075106001007 NeuB family; Region: NeuB; cl00496 1075106001008 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1075106001009 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1075106001010 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1075106001011 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1075106001012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1075106001013 dimer interface [polypeptide binding]; other site 1075106001014 phosphorylation site [posttranslational modification] 1075106001015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106001016 ATP binding site [chemical binding]; other site 1075106001017 Mg2+ binding site [ion binding]; other site 1075106001018 G-X-G motif; other site 1075106001019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1075106001020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106001021 active site 1075106001022 phosphorylation site [posttranslational modification] 1075106001023 intermolecular recognition site; other site 1075106001024 dimerization interface [polypeptide binding]; other site 1075106001025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1075106001026 DNA binding site [nucleotide binding] 1075106001027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1075106001028 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1075106001029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1075106001030 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 1075106001031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001032 dimer interface [polypeptide binding]; other site 1075106001033 conserved gate region; other site 1075106001034 putative PBP binding loops; other site 1075106001035 ABC-ATPase subunit interface; other site 1075106001036 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1075106001037 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1075106001038 Walker A/P-loop; other site 1075106001039 ATP binding site [chemical binding]; other site 1075106001040 Q-loop/lid; other site 1075106001041 ABC transporter signature motif; other site 1075106001042 Walker B; other site 1075106001043 D-loop; other site 1075106001044 H-loop/switch region; other site 1075106001045 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1075106001046 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1075106001047 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1075106001048 intersubunit interface [polypeptide binding]; other site 1075106001049 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1075106001050 23S rRNA interface [nucleotide binding]; other site 1075106001051 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1075106001052 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1075106001053 peripheral dimer interface [polypeptide binding]; other site 1075106001054 core dimer interface [polypeptide binding]; other site 1075106001055 L10 interface [polypeptide binding]; other site 1075106001056 L11 interface [polypeptide binding]; other site 1075106001057 putative EF-Tu interaction site [polypeptide binding]; other site 1075106001058 putative EF-G interaction site [polypeptide binding]; other site 1075106001059 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106001060 phosphopeptide binding site; other site 1075106001061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106001062 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1075106001063 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1075106001064 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1075106001065 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1075106001066 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1075106001067 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106001068 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1075106001069 oligomerisation interface [polypeptide binding]; other site 1075106001070 mobile loop; other site 1075106001071 roof hairpin; other site 1075106001072 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1075106001073 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1075106001074 FAD binding domain; Region: FAD_binding_4; pfam01565 1075106001075 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1075106001076 amino acid transporter; Region: 2A0306; TIGR00909 1075106001077 Spore germination protein; Region: Spore_permease; cl15802 1075106001078 Spore germination protein; Region: Spore_permease; cl15802 1075106001079 Ferredoxin [Energy production and conversion]; Region: COG1146 1075106001080 4Fe-4S binding domain; Region: Fer4; cl02805 1075106001081 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 1075106001082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106001083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001084 homodimer interface [polypeptide binding]; other site 1075106001085 catalytic residue [active] 1075106001086 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1075106001087 active site 1075106001088 DNA polymerase IV; Validated; Region: PRK02406 1075106001089 DNA binding site [nucleotide binding] 1075106001090 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1075106001091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106001092 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1075106001093 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1075106001094 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1075106001095 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1075106001096 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1075106001097 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1075106001098 23S rRNA interface [nucleotide binding]; other site 1075106001099 L3 interface [polypeptide binding]; other site 1075106001100 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1075106001101 pullulanase, type I; Region: pulA_typeI; TIGR02104 1075106001102 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1075106001103 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1075106001104 active site 1075106001105 catalytic site [active] 1075106001106 Helix-turn-helix domains; Region: HTH; cl00088 1075106001107 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1075106001108 D-allose kinase; Provisional; Region: PRK09698 1075106001109 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1075106001110 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1075106001111 putative catalytic cysteine [active] 1075106001112 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1075106001113 putative active site [active] 1075106001114 metal binding site [ion binding]; metal-binding site 1075106001115 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1075106001116 YwiC-like protein; Region: YwiC; pfam14256 1075106001117 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1075106001118 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1075106001119 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1075106001120 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1075106001121 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1075106001122 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1075106001123 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1075106001124 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1075106001125 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1075106001126 putative translocon binding site; other site 1075106001127 protein-rRNA interface [nucleotide binding]; other site 1075106001128 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1075106001129 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1075106001130 G-X-X-G motif; other site 1075106001131 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1075106001132 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1075106001133 23S rRNA interface [nucleotide binding]; other site 1075106001134 5S rRNA interface [nucleotide binding]; other site 1075106001135 putative antibiotic binding site [chemical binding]; other site 1075106001136 L25 interface [polypeptide binding]; other site 1075106001137 L27 interface [polypeptide binding]; other site 1075106001138 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1075106001139 23S rRNA interface [nucleotide binding]; other site 1075106001140 putative translocon interaction site; other site 1075106001141 signal recognition particle (SRP54) interaction site; other site 1075106001142 L23 interface [polypeptide binding]; other site 1075106001143 trigger factor interaction site; other site 1075106001144 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1075106001145 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1075106001146 KOW motif; Region: KOW; cl00354 1075106001147 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1075106001148 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1075106001149 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1075106001150 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1075106001151 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1075106001152 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1075106001153 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1075106001154 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1075106001155 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1075106001156 23S rRNA interface [nucleotide binding]; other site 1075106001157 L21e interface [polypeptide binding]; other site 1075106001158 5S rRNA interface [nucleotide binding]; other site 1075106001159 L27 interface [polypeptide binding]; other site 1075106001160 L5 interface [polypeptide binding]; other site 1075106001161 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1075106001162 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1075106001163 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1075106001164 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1075106001165 23S rRNA binding site [nucleotide binding]; other site 1075106001166 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1075106001167 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1075106001168 SecY translocase; Region: SecY; pfam00344 1075106001169 adenylate kinase; Reviewed; Region: adk; PRK00279 1075106001170 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1075106001171 AMP-binding site [chemical binding]; other site 1075106001172 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1075106001173 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1075106001174 rRNA binding site [nucleotide binding]; other site 1075106001175 predicted 30S ribosome binding site; other site 1075106001176 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1075106001177 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1075106001178 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1075106001179 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 1075106001180 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1075106001181 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1075106001182 alphaNTD homodimer interface [polypeptide binding]; other site 1075106001183 alphaNTD - beta interaction site [polypeptide binding]; other site 1075106001184 alphaNTD - beta' interaction site [polypeptide binding]; other site 1075106001185 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1075106001186 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1075106001187 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1075106001188 active site 1075106001189 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1075106001190 NusA N-terminal domain; Region: NusA_N; pfam08529 1075106001191 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1075106001192 RNA binding site [nucleotide binding]; other site 1075106001193 homodimer interface [polypeptide binding]; other site 1075106001194 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1075106001195 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1075106001196 G-X-X-G motif; other site 1075106001197 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1075106001198 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1075106001199 translation initiation factor IF-2; Region: IF-2; TIGR00487 1075106001200 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1075106001201 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1075106001202 G1 box; other site 1075106001203 putative GEF interaction site [polypeptide binding]; other site 1075106001204 GTP/Mg2+ binding site [chemical binding]; other site 1075106001205 Switch I region; other site 1075106001206 G2 box; other site 1075106001207 G3 box; other site 1075106001208 Switch II region; other site 1075106001209 G4 box; other site 1075106001210 G5 box; other site 1075106001211 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1075106001212 Translation-initiation factor 2; Region: IF-2; pfam11987 1075106001213 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1075106001214 Ribosome-binding factor A; Region: RBFA; cl00542 1075106001215 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1075106001216 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1075106001217 RNA binding site [nucleotide binding]; other site 1075106001218 active site 1075106001219 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1075106001220 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106001221 active site 1075106001222 nucleotide binding site [chemical binding]; other site 1075106001223 HIGH motif; other site 1075106001224 KMSKS motif; other site 1075106001225 Riboflavin kinase; Region: Flavokinase; cl03312 1075106001226 DNA repair protein RadA; Provisional; Region: PRK11823 1075106001227 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106001228 Walker A motif; other site 1075106001229 ATP binding site [chemical binding]; other site 1075106001230 Walker B motif; other site 1075106001231 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1075106001232 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1075106001233 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106001234 active site 1075106001235 dimer interface [polypeptide binding]; other site 1075106001236 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1075106001237 RNA/DNA hybrid binding site [nucleotide binding]; other site 1075106001238 active site 1075106001239 seryl-tRNA synthetase; Provisional; Region: PRK05431 1075106001240 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1075106001241 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1075106001242 dimer interface [polypeptide binding]; other site 1075106001243 active site 1075106001244 motif 1; other site 1075106001245 motif 2; other site 1075106001246 motif 3; other site 1075106001247 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1075106001248 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1075106001249 phosphoglucomutase; Validated; Region: PRK07564 1075106001250 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1075106001251 active site 1075106001252 substrate binding site [chemical binding]; other site 1075106001253 metal binding site [ion binding]; metal-binding site 1075106001254 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1075106001255 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 1075106001256 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1075106001257 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1075106001258 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1075106001259 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106001260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106001261 active site 1075106001262 phosphorylation site [posttranslational modification] 1075106001263 intermolecular recognition site; other site 1075106001264 dimerization interface [polypeptide binding]; other site 1075106001265 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106001266 DNA binding residues [nucleotide binding] 1075106001267 dimerization interface [polypeptide binding]; other site 1075106001268 PspC domain; Region: PspC; cl00864 1075106001269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106001270 PspC domain; Region: PspC; cl00864 1075106001271 IncA protein; Region: IncA; pfam04156 1075106001272 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1075106001273 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1075106001274 homodimer interface [polypeptide binding]; other site 1075106001275 substrate-cofactor binding pocket; other site 1075106001276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001277 catalytic residue [active] 1075106001278 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1075106001279 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1075106001280 catalytic residue [active] 1075106001281 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1075106001282 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1075106001283 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1075106001284 dimer interface [polypeptide binding]; other site 1075106001285 putative anticodon binding site; other site 1075106001286 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1075106001287 motif 1; other site 1075106001288 dimer interface [polypeptide binding]; other site 1075106001289 active site 1075106001290 motif 2; other site 1075106001291 motif 3; other site 1075106001292 Phospholipase B; Region: Phospholip_B; pfam04916 1075106001293 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1075106001294 trimer interface [polypeptide binding]; other site 1075106001295 active site 1075106001296 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1075106001297 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 1075106001298 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1075106001299 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1075106001300 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1075106001301 Spore germination protein; Region: Spore_permease; cl15802 1075106001302 UbiA prenyltransferase family; Region: UbiA; cl00337 1075106001303 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106001304 catalytic core [active] 1075106001305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106001306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106001307 oxidoreductase 1075106001308 oxidoreductase 1075106001309 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1075106001310 mannose-6-phosphate isomerase; Region: PLN02288 1075106001311 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 1075106001312 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1075106001313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106001314 ATP binding site [chemical binding]; other site 1075106001315 Mg2+ binding site [ion binding]; other site 1075106001316 G-X-G motif; other site 1075106001317 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1075106001318 PhoU domain; Region: PhoU; pfam01895 1075106001319 PhoU domain; Region: PhoU; pfam01895 1075106001320 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1075106001321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1075106001322 catalytic residue [active] 1075106001323 NlpC/P60 family; Region: NLPC_P60; cl11438 1075106001324 NlpC/P60 family; Region: NLPC_P60; cl11438 1075106001325 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1075106001326 Ligand Binding Site [chemical binding]; other site 1075106001327 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1075106001328 Ligand Binding Site [chemical binding]; other site 1075106001329 OsmC-like protein; Region: OsmC; cl00767 1075106001330 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1075106001331 dimerization interface [polypeptide binding]; other site 1075106001332 active site 1075106001333 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1075106001334 folate binding site [chemical binding]; other site 1075106001335 NADP+ binding site [chemical binding]; other site 1075106001336 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1075106001337 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1075106001338 active site 1075106001339 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1075106001340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106001341 NAD(P) binding site [chemical binding]; other site 1075106001342 active site 1075106001343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106001344 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1075106001345 putative active site [active] 1075106001346 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1075106001347 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106001348 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106001349 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1075106001350 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1075106001351 putative active site [active] 1075106001352 putative metal-binding site [ion binding]; other site 1075106001353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1075106001354 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1075106001355 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1075106001356 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1075106001357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1075106001358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106001359 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1075106001360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1075106001361 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1075106001362 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1075106001363 Protein of unknown function, DUF488; Region: DUF488; cl01246 1075106001364 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1075106001365 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1075106001366 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1075106001367 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 1075106001368 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1075106001369 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 1075106001370 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1075106001371 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106001372 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106001373 DNA binding site [nucleotide binding] 1075106001374 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1075106001375 putative dimerization interface [polypeptide binding]; other site 1075106001376 putative ligand binding site [chemical binding]; other site 1075106001377 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1075106001378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106001379 motif II; other site 1075106001380 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1075106001381 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1075106001382 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1075106001383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1075106001384 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1075106001385 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 1075106001386 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1075106001387 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1075106001388 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106001389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001390 dimer interface [polypeptide binding]; other site 1075106001391 conserved gate region; other site 1075106001392 putative PBP binding loops; other site 1075106001393 ABC-ATPase subunit interface; other site 1075106001394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001395 dimer interface [polypeptide binding]; other site 1075106001396 conserved gate region; other site 1075106001397 putative PBP binding loops; other site 1075106001398 ABC-ATPase subunit interface; other site 1075106001399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106001400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106001401 DNA binding site [nucleotide binding] 1075106001402 domain linker motif; other site 1075106001403 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1075106001404 ligand binding site [chemical binding]; other site 1075106001405 dimerization interface (open form) [polypeptide binding]; other site 1075106001406 dimerization interface (closed form) [polypeptide binding]; other site 1075106001407 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106001408 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1075106001409 active site 1075106001410 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1075106001411 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1075106001412 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1075106001413 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106001414 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1075106001415 DXD motif; other site 1075106001416 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1075106001417 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1075106001418 Walker A/P-loop; other site 1075106001419 ATP binding site [chemical binding]; other site 1075106001420 Q-loop/lid; other site 1075106001421 ABC transporter signature motif; other site 1075106001422 Walker B; other site 1075106001423 D-loop; other site 1075106001424 H-loop/switch region; other site 1075106001425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1075106001426 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1075106001427 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1075106001428 Ligand Binding Site [chemical binding]; other site 1075106001429 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106001430 active site 1075106001431 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1075106001432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106001433 Walker A motif; other site 1075106001434 ATP binding site [chemical binding]; other site 1075106001435 Walker B motif; other site 1075106001436 arginine finger; other site 1075106001437 Peptidase family M41; Region: Peptidase_M41; pfam01434 1075106001438 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1075106001439 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1075106001440 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1075106001441 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1075106001442 active site 1075106001443 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1075106001444 catalytic triad [active] 1075106001445 dimer interface [polypeptide binding]; other site 1075106001446 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1075106001447 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106001448 Walker A/P-loop; other site 1075106001449 ATP binding site [chemical binding]; other site 1075106001450 Q-loop/lid; other site 1075106001451 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1075106001452 ABC transporter; Region: ABC_tran_2; pfam12848 1075106001453 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1075106001454 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1075106001455 active site 1075106001456 catalytic residues [active] 1075106001457 metal binding site [ion binding]; metal-binding site 1075106001458 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1075106001459 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1075106001460 homodimer interface [polypeptide binding]; other site 1075106001461 substrate-cofactor binding pocket; other site 1075106001462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001463 catalytic residue [active] 1075106001464 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1075106001465 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1075106001466 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1075106001467 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1075106001468 active site 1075106001469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106001470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106001471 DNA binding site [nucleotide binding] 1075106001472 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1075106001473 putative ligand binding site [chemical binding]; other site 1075106001474 putative dimerization interface [polypeptide binding]; other site 1075106001475 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1075106001476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1075106001477 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1075106001478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001479 dimer interface [polypeptide binding]; other site 1075106001480 conserved gate region; other site 1075106001481 putative PBP binding loops; other site 1075106001482 ABC-ATPase subunit interface; other site 1075106001483 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106001484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001485 dimer interface [polypeptide binding]; other site 1075106001486 conserved gate region; other site 1075106001487 putative PBP binding loops; other site 1075106001488 ABC-ATPase subunit interface; other site 1075106001489 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1075106001490 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1075106001491 inhibitor binding site; inhibition site 1075106001492 active site 1075106001493 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1075106001494 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1075106001495 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106001496 substrate binding pocket [chemical binding]; other site 1075106001497 catalytic triad [active] 1075106001498 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1075106001499 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1075106001500 active site 1075106001501 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1075106001502 N- and C-terminal domain interface [polypeptide binding]; other site 1075106001503 D-xylulose kinase; Region: XylB; TIGR01312 1075106001504 active site 1075106001505 MgATP binding site [chemical binding]; other site 1075106001506 catalytic site [active] 1075106001507 metal binding site [ion binding]; metal-binding site 1075106001508 carbohydrate binding site [chemical binding]; other site 1075106001509 Helix-turn-helix domains; Region: HTH; cl00088 1075106001510 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106001511 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1075106001512 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1075106001513 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1075106001514 RF-1 domain; Region: RF-1; cl02875 1075106001515 RF-1 domain; Region: RF-1; cl02875 1075106001516 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1075106001517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106001518 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1075106001519 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1075106001520 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1075106001521 Mg++ binding site [ion binding]; other site 1075106001522 putative catalytic motif [active] 1075106001523 substrate binding site [chemical binding]; other site 1075106001524 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1075106001525 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1075106001526 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 1075106001527 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1075106001528 active site 1075106001529 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1075106001530 catalytic site [active] 1075106001531 putative active site [active] 1075106001532 putative substrate binding site [chemical binding]; other site 1075106001533 dimer interface [polypeptide binding]; other site 1075106001534 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106001535 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1075106001536 active site 1075106001537 motif I; other site 1075106001538 motif II; other site 1075106001539 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106001540 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106001541 PIF1-like helicase; Region: PIF1; pfam05970 1075106001542 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 1075106001543 Protein of unknown function (DUF805); Region: DUF805; cl01224 1075106001544 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1075106001545 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 1075106001546 dimer interface [polypeptide binding]; other site 1075106001547 motif 1; other site 1075106001548 active site 1075106001549 motif 2; other site 1075106001550 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1075106001551 putative deacylase active site [active] 1075106001552 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1075106001553 active site 1075106001554 motif 3; other site 1075106001555 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1075106001556 anticodon binding site; other site 1075106001557 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1075106001558 dimer interface [polypeptide binding]; other site 1075106001559 ssDNA binding site [nucleotide binding]; other site 1075106001560 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106001561 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1075106001562 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1075106001563 active site 1075106001564 Zn binding site [ion binding]; other site 1075106001565 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1075106001566 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1075106001567 active site 1075106001568 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1075106001569 Citrate synthase; Region: Citrate_synt; pfam00285 1075106001570 oxalacetate binding site [chemical binding]; other site 1075106001571 citrylCoA binding site [chemical binding]; other site 1075106001572 coenzyme A binding site [chemical binding]; other site 1075106001573 catalytic triad [active] 1075106001574 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 1075106001575 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 1075106001576 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1075106001577 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1075106001578 putative trimer interface [polypeptide binding]; other site 1075106001579 putative CoA binding site [chemical binding]; other site 1075106001580 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1075106001581 RF-1 domain; Region: RF-1; cl02875 1075106001582 RF-1 domain; Region: RF-1; cl02875 1075106001583 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1075106001584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106001585 Walker A/P-loop; other site 1075106001586 ATP binding site [chemical binding]; other site 1075106001587 Q-loop/lid; other site 1075106001588 ABC transporter signature motif; other site 1075106001589 Walker B; other site 1075106001590 D-loop; other site 1075106001591 H-loop/switch region; other site 1075106001592 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1075106001593 FtsX-like permease family; Region: FtsX; cl15850 1075106001594 NlpC/P60 family; Region: NLPC_P60; cl11438 1075106001595 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1075106001596 SmpB-tmRNA interface; other site 1075106001597 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106001598 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1075106001599 substrate binding pocket [chemical binding]; other site 1075106001600 membrane-bound complex binding site; other site 1075106001601 hinge residues; other site 1075106001602 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106001603 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1075106001604 substrate binding pocket [chemical binding]; other site 1075106001605 membrane-bound complex binding site; other site 1075106001606 hinge residues; other site 1075106001607 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1075106001608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001609 dimer interface [polypeptide binding]; other site 1075106001610 conserved gate region; other site 1075106001611 putative PBP binding loops; other site 1075106001612 ABC-ATPase subunit interface; other site 1075106001613 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1075106001614 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1075106001615 Walker A/P-loop; other site 1075106001616 ATP binding site [chemical binding]; other site 1075106001617 Q-loop/lid; other site 1075106001618 ABC transporter signature motif; other site 1075106001619 Walker B; other site 1075106001620 D-loop; other site 1075106001621 H-loop/switch region; other site 1075106001622 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1075106001623 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106001625 active site 1075106001626 phosphorylation site [posttranslational modification] 1075106001627 intermolecular recognition site; other site 1075106001628 dimerization interface [polypeptide binding]; other site 1075106001629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106001630 DNA binding residues [nucleotide binding] 1075106001631 dimerization interface [polypeptide binding]; other site 1075106001632 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1075106001633 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1075106001634 glutaminase active site [active] 1075106001635 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1075106001636 dimer interface [polypeptide binding]; other site 1075106001637 active site 1075106001638 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1075106001639 dimer interface [polypeptide binding]; other site 1075106001640 active site 1075106001641 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1075106001642 active site 1075106001643 Type III pantothenate kinase; Region: Pan_kinase; cl09130 1075106001644 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1075106001645 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1075106001646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1075106001647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001648 dimer interface [polypeptide binding]; other site 1075106001649 conserved gate region; other site 1075106001650 putative PBP binding loops; other site 1075106001651 ABC-ATPase subunit interface; other site 1075106001652 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1075106001653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001654 dimer interface [polypeptide binding]; other site 1075106001655 conserved gate region; other site 1075106001656 putative PBP binding loops; other site 1075106001657 ABC-ATPase subunit interface; other site 1075106001658 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1075106001659 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1075106001660 Walker A/P-loop; other site 1075106001661 ATP binding site [chemical binding]; other site 1075106001662 Q-loop/lid; other site 1075106001663 ABC transporter signature motif; other site 1075106001664 Walker B; other site 1075106001665 D-loop; other site 1075106001666 H-loop/switch region; other site 1075106001667 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1075106001668 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1075106001669 Walker A/P-loop; other site 1075106001670 ATP binding site [chemical binding]; other site 1075106001671 Q-loop/lid; other site 1075106001672 ABC transporter signature motif; other site 1075106001673 Walker B; other site 1075106001674 D-loop; other site 1075106001675 H-loop/switch region; other site 1075106001676 cystathionine gamma-synthase; Provisional; Region: PRK07811 1075106001677 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1075106001678 homodimer interface [polypeptide binding]; other site 1075106001679 substrate-cofactor binding pocket; other site 1075106001680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001681 catalytic residue [active] 1075106001682 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1075106001683 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1075106001684 dimer interface [polypeptide binding]; other site 1075106001685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001686 catalytic residue [active] 1075106001687 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1075106001688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106001689 ATP binding site [chemical binding]; other site 1075106001690 putative Mg++ binding site [ion binding]; other site 1075106001691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106001692 nucleotide binding region [chemical binding]; other site 1075106001693 ATP-binding site [chemical binding]; other site 1075106001694 RQC domain; Region: RQC; cl09632 1075106001695 HRDC domain; Region: HRDC; cl02578 1075106001696 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1075106001697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1075106001698 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106001699 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1075106001700 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1075106001701 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1075106001702 active site 1075106001703 8-oxo-dGMP binding site [chemical binding]; other site 1075106001704 nudix motif; other site 1075106001705 metal binding site [ion binding]; metal-binding site 1075106001706 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1075106001707 PLD-like domain; Region: PLDc_2; pfam13091 1075106001708 putative homodimer interface [polypeptide binding]; other site 1075106001709 putative active site [active] 1075106001710 catalytic site [active] 1075106001711 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1075106001712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106001713 ATP binding site [chemical binding]; other site 1075106001714 putative Mg++ binding site [ion binding]; other site 1075106001715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106001716 nucleotide binding region [chemical binding]; other site 1075106001717 ATP-binding site [chemical binding]; other site 1075106001718 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1075106001719 Fic family protein [Function unknown]; Region: COG3177 1075106001720 Protein of unknown function DUF262; Region: DUF262; cl14890 1075106001721 Protein of unknown function DUF262; Region: DUF262; cl14890 1075106001722 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1075106001723 Fic/DOC family; Region: Fic; cl00960 1075106001724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1075106001725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106001726 Coenzyme A binding pocket [chemical binding]; other site 1075106001727 Phospholipid methyltransferase; Region: PEMT; cl00763 1075106001728 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1075106001729 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1075106001730 putative active site [active] 1075106001731 metal binding site [ion binding]; metal-binding site 1075106001732 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1075106001733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1075106001734 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1075106001735 alanine racemase; Reviewed; Region: alr; PRK00053 1075106001736 active site 1075106001737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1075106001738 dimer interface [polypeptide binding]; other site 1075106001739 substrate binding site [chemical binding]; other site 1075106001740 catalytic residues [active] 1075106001741 DNA primase; Validated; Region: dnaG; PRK05667 1075106001742 CHC2 zinc finger; Region: zf-CHC2; cl15369 1075106001743 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1075106001744 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1075106001745 active site 1075106001746 metal binding site [ion binding]; metal-binding site 1075106001747 interdomain interaction site; other site 1075106001748 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1075106001749 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1075106001750 transmembrane helices; other site 1075106001751 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1075106001752 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1075106001753 TPP-binding site; other site 1075106001754 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1075106001755 PYR/PP interface [polypeptide binding]; other site 1075106001756 dimer interface [polypeptide binding]; other site 1075106001757 TPP binding site [chemical binding]; other site 1075106001758 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1075106001759 AIR carboxylase; Region: AIRC; cl00310 1075106001760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106001761 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1075106001762 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106001763 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106001764 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1075106001765 metal binding site 2 [ion binding]; metal-binding site 1075106001766 putative DNA binding helix; other site 1075106001767 metal binding site 1 [ion binding]; metal-binding site 1075106001768 dimer interface [polypeptide binding]; other site 1075106001769 structural Zn2+ binding site [ion binding]; other site 1075106001770 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1075106001771 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106001772 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1075106001773 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1075106001774 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106001775 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1075106001776 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1075106001777 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1075106001778 dimerization interface [polypeptide binding]; other site 1075106001779 putative ATP binding site [chemical binding]; other site 1075106001780 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1075106001781 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1075106001782 active site 1075106001783 tetramer interface [polypeptide binding]; other site 1075106001784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106001785 active site 1075106001786 Y-family of DNA polymerases; Region: PolY; cl12025 1075106001787 DNA polymerase IV; Reviewed; Region: PRK03103 1075106001788 active site 1075106001789 DNA binding site [nucleotide binding] 1075106001790 Domain of unknown function (DUF697); Region: DUF697; cl12064 1075106001791 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1075106001792 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1075106001793 Short C-terminal domain; Region: SHOCT; cl01373 1075106001794 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1075106001795 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1075106001796 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1075106001797 dimerization interface [polypeptide binding]; other site 1075106001798 ATP binding site [chemical binding]; other site 1075106001799 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1075106001800 dimerization interface [polypeptide binding]; other site 1075106001801 ATP binding site [chemical binding]; other site 1075106001802 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1075106001803 conserved cys residue [active] 1075106001804 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1075106001805 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1075106001806 ATP binding site [chemical binding]; other site 1075106001807 active site 1075106001808 substrate binding site [chemical binding]; other site 1075106001809 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1075106001810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106001811 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106001812 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1075106001813 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1075106001814 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1075106001815 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1075106001816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1075106001817 catalytic residue [active] 1075106001818 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1075106001819 S17 interaction site [polypeptide binding]; other site 1075106001820 S8 interaction site; other site 1075106001821 16S rRNA interaction site [nucleotide binding]; other site 1075106001822 streptomycin interaction site [chemical binding]; other site 1075106001823 23S rRNA interaction site [nucleotide binding]; other site 1075106001824 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1075106001825 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1075106001826 elongation factor G; Reviewed; Region: PRK00007 1075106001827 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1075106001828 G1 box; other site 1075106001829 putative GEF interaction site [polypeptide binding]; other site 1075106001830 GTP/Mg2+ binding site [chemical binding]; other site 1075106001831 Switch I region; other site 1075106001832 G2 box; other site 1075106001833 G3 box; other site 1075106001834 Switch II region; other site 1075106001835 G4 box; other site 1075106001836 G5 box; other site 1075106001837 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1075106001838 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1075106001839 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1075106001840 elongation factor Tu; Reviewed; Region: PRK00049 1075106001841 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1075106001842 G1 box; other site 1075106001843 GEF interaction site [polypeptide binding]; other site 1075106001844 GTP/Mg2+ binding site [chemical binding]; other site 1075106001845 Switch I region; other site 1075106001846 G2 box; other site 1075106001847 G3 box; other site 1075106001848 Switch II region; other site 1075106001849 G4 box; other site 1075106001850 G5 box; other site 1075106001851 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1075106001852 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1075106001853 Antibiotic Binding Site [chemical binding]; other site 1075106001854 Plant phosphoribosyltransferase C-terminal; Region: PRT_C; pfam08372 1075106001855 elongation factor P; Validated; Region: PRK00529 1075106001856 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1075106001857 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1075106001858 RNA binding site [nucleotide binding]; other site 1075106001859 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1075106001860 RNA binding site [nucleotide binding]; other site 1075106001861 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1075106001862 putative RNA binding site [nucleotide binding]; other site 1075106001863 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1075106001864 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1075106001865 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1075106001866 catalytic site [active] 1075106001867 subunit interface [polypeptide binding]; other site 1075106001868 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1075106001869 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1075106001870 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106001871 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1075106001872 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1075106001873 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106001874 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1075106001875 IMP binding site; other site 1075106001876 dimer interface [polypeptide binding]; other site 1075106001877 interdomain contacts; other site 1075106001878 partial ornithine binding site; other site 1075106001879 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1075106001880 active site 1075106001881 dimer interface [polypeptide binding]; other site 1075106001882 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1075106001883 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1075106001884 catalytic site [active] 1075106001885 G-X2-G-X-G-K; other site 1075106001886 Dehydratase family; Region: ILVD_EDD; cl00340 1075106001887 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1075106001888 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1075106001889 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1075106001890 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1075106001891 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1075106001892 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1075106001893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106001894 S-adenosylmethionine binding site [chemical binding]; other site 1075106001895 primosome assembly protein PriA; Provisional; Region: PRK14873 1075106001896 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1075106001897 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1075106001898 putative active site [active] 1075106001899 substrate binding site [chemical binding]; other site 1075106001900 putative cosubstrate binding site; other site 1075106001901 catalytic site [active] 1075106001902 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1075106001903 substrate binding site [chemical binding]; other site 1075106001904 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1075106001905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106001906 motif II; other site 1075106001907 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1075106001908 proteasome ATPase; Region: pup_AAA; TIGR03689 1075106001909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106001910 Walker A motif; other site 1075106001911 ATP binding site [chemical binding]; other site 1075106001912 Walker B motif; other site 1075106001913 arginine finger; other site 1075106001914 Pup-ligase protein; Region: Pup_ligase; cl15463 1075106001915 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1075106001916 active site 1075106001917 Pup-like protein; Region: Pup; cl05289 1075106001918 Pup-ligase protein; Region: Pup_ligase; cl15463 1075106001919 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1075106001920 IHF dimer interface [polypeptide binding]; other site 1075106001921 IHF - DNA interface [nucleotide binding]; other site 1075106001922 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1075106001923 adenylosuccinate lyase; Provisional; Region: PRK09285 1075106001924 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1075106001925 tetramer interface [polypeptide binding]; other site 1075106001926 active site 1075106001927 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1075106001928 Secretory lipase; Region: LIP; pfam03583 1075106001929 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1075106001930 metal ion-dependent adhesion site (MIDAS); other site 1075106001931 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1075106001932 metal ion-dependent adhesion site (MIDAS); other site 1075106001933 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1075106001934 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1075106001935 MoxR-like ATPases [General function prediction only]; Region: COG0714 1075106001936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106001937 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1075106001938 ligand binding site [chemical binding]; other site 1075106001939 active site 1075106001940 UGI interface [polypeptide binding]; other site 1075106001941 catalytic site [active] 1075106001942 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1075106001943 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1075106001944 DNA-binding site [nucleotide binding]; DNA binding site 1075106001945 RNA-binding motif; other site 1075106001946 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1075106001947 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1075106001948 ring oligomerisation interface [polypeptide binding]; other site 1075106001949 ATP/Mg binding site [chemical binding]; other site 1075106001950 stacking interactions; other site 1075106001951 hinge regions; other site 1075106001952 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1075106001953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1075106001954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106001955 active site 1075106001956 phosphorylation site [posttranslational modification] 1075106001957 intermolecular recognition site; other site 1075106001958 dimerization interface [polypeptide binding]; other site 1075106001959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1075106001960 DNA binding site [nucleotide binding] 1075106001961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1075106001962 dimerization interface [polypeptide binding]; other site 1075106001963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1075106001964 dimer interface [polypeptide binding]; other site 1075106001965 phosphorylation site [posttranslational modification] 1075106001966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106001967 ATP binding site [chemical binding]; other site 1075106001968 Mg2+ binding site [ion binding]; other site 1075106001969 G-X-G motif; other site 1075106001970 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1075106001971 DNA-binding site [nucleotide binding]; DNA binding site 1075106001972 RNA-binding motif; other site 1075106001973 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1075106001974 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1075106001975 Ligand Binding Site [chemical binding]; other site 1075106001976 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1075106001977 Ligand Binding Site [chemical binding]; other site 1075106001978 Clp protease ATP binding subunit; Region: clpC; CHL00095 1075106001979 Clp amino terminal domain; Region: Clp_N; pfam02861 1075106001980 Clp amino terminal domain; Region: Clp_N; pfam02861 1075106001981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106001982 Walker A motif; other site 1075106001983 ATP binding site [chemical binding]; other site 1075106001984 Walker B motif; other site 1075106001985 arginine finger; other site 1075106001986 UvrB/uvrC motif; Region: UVR; pfam02151 1075106001987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106001988 Walker A motif; other site 1075106001989 ATP binding site [chemical binding]; other site 1075106001990 Walker B motif; other site 1075106001991 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1075106001992 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1075106001993 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1075106001994 dimer interface [polypeptide binding]; other site 1075106001995 anticodon binding site; other site 1075106001996 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1075106001997 motif 1; other site 1075106001998 dimer interface [polypeptide binding]; other site 1075106001999 active site 1075106002000 motif 2; other site 1075106002001 GAD domain; Region: GAD; pfam02938 1075106002002 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1075106002003 active site 1075106002004 motif 3; other site 1075106002005 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1075106002006 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1075106002007 dimer interface [polypeptide binding]; other site 1075106002008 motif 1; other site 1075106002009 active site 1075106002010 motif 2; other site 1075106002011 motif 3; other site 1075106002012 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1075106002013 anticodon binding site; other site 1075106002014 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1075106002015 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1075106002016 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106002017 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1075106002018 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1075106002019 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1075106002020 Walker A/P-loop; other site 1075106002021 ATP binding site [chemical binding]; other site 1075106002022 Q-loop/lid; other site 1075106002023 ABC transporter signature motif; other site 1075106002024 Walker B; other site 1075106002025 D-loop; other site 1075106002026 H-loop/switch region; other site 1075106002027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106002028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1075106002029 substrate binding pocket [chemical binding]; other site 1075106002030 membrane-bound complex binding site; other site 1075106002031 hinge residues; other site 1075106002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106002033 dimer interface [polypeptide binding]; other site 1075106002034 conserved gate region; other site 1075106002035 ABC-ATPase subunit interface; other site 1075106002036 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1075106002037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106002038 dimer interface [polypeptide binding]; other site 1075106002039 conserved gate region; other site 1075106002040 putative PBP binding loops; other site 1075106002041 ABC-ATPase subunit interface; other site 1075106002042 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1075106002043 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1075106002044 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106002045 ATP binding site [chemical binding]; other site 1075106002046 putative Mg++ binding site [ion binding]; other site 1075106002047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106002048 nucleotide binding region [chemical binding]; other site 1075106002049 ATP-binding site [chemical binding]; other site 1075106002050 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1075106002051 recombination factor protein RarA; Reviewed; Region: PRK13342 1075106002052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106002053 Walker A motif; other site 1075106002054 ATP binding site [chemical binding]; other site 1075106002055 Walker B motif; other site 1075106002056 arginine finger; other site 1075106002057 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1075106002058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106002059 putative substrate translocation pore; other site 1075106002060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106002061 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1075106002062 AMP-binding enzyme; Region: AMP-binding; cl15778 1075106002063 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1075106002064 MULE transposase domain; Region: MULE; pfam10551 1075106002065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002066 Coenzyme A binding pocket [chemical binding]; other site 1075106002067 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 1075106002068 hypothetical protein; Provisional; Region: PRK11770 1075106002069 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1075106002070 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1075106002071 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1075106002072 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1075106002073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106002074 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106002075 active site 1075106002076 catalytic tetrad [active] 1075106002077 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106002078 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106002079 Walker A/P-loop; other site 1075106002080 ATP binding site [chemical binding]; other site 1075106002081 Q-loop/lid; other site 1075106002082 ABC transporter signature motif; other site 1075106002083 Walker B; other site 1075106002084 D-loop; other site 1075106002085 H-loop/switch region; other site 1075106002086 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106002087 Walker A/P-loop; other site 1075106002088 ATP binding site [chemical binding]; other site 1075106002089 Q-loop/lid; other site 1075106002090 ABC transporter signature motif; other site 1075106002091 Walker B; other site 1075106002092 D-loop; other site 1075106002093 H-loop/switch region; other site 1075106002094 Cobalt transport protein; Region: CbiQ; cl00463 1075106002095 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1075106002096 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1075106002097 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106002098 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1075106002099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106002100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002101 homodimer interface [polypeptide binding]; other site 1075106002102 catalytic residue [active] 1075106002103 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1075106002104 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002105 Walker A/P-loop; other site 1075106002106 ATP binding site [chemical binding]; other site 1075106002107 Q-loop/lid; other site 1075106002108 ABC transporter signature motif; other site 1075106002109 Walker B; other site 1075106002110 D-loop; other site 1075106002111 H-loop/switch region; other site 1075106002112 Ligase N family; Region: LIGANc; smart00532 1075106002113 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1075106002114 nucleotide binding pocket [chemical binding]; other site 1075106002115 K-X-D-G motif; other site 1075106002116 catalytic site [active] 1075106002117 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1075106002118 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1075106002119 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1075106002120 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1075106002121 Dimer interface [polypeptide binding]; other site 1075106002122 Domain of unknown function DUF59; Region: DUF59; cl00941 1075106002123 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1075106002124 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1075106002125 glutamine synthetase, type I; Region: GlnA; TIGR00653 1075106002126 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1075106002127 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1075106002128 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1075106002129 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1075106002130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1075106002132 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1075106002133 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1075106002134 hypothetical protein; Provisional; Region: PRK07907 1075106002135 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1075106002136 active site 1075106002137 metal binding site [ion binding]; metal-binding site 1075106002138 dimer interface [polypeptide binding]; other site 1075106002139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106002140 Histidine kinase; Region: HisKA_3; pfam07730 1075106002141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1075106002142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002143 ABC transporter signature motif; other site 1075106002144 Walker B; other site 1075106002145 D-loop; other site 1075106002146 H-loop/switch region; other site 1075106002147 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1075106002148 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106002149 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106002150 Walker A/P-loop; other site 1075106002151 ATP binding site [chemical binding]; other site 1075106002152 Q-loop/lid; other site 1075106002153 ABC transporter signature motif; other site 1075106002154 Walker B; other site 1075106002155 D-loop; other site 1075106002156 H-loop/switch region; other site 1075106002157 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106002158 Walker A/P-loop; other site 1075106002159 ATP binding site [chemical binding]; other site 1075106002160 Q-loop/lid; other site 1075106002161 ABC transporter signature motif; other site 1075106002162 Walker B; other site 1075106002163 D-loop; other site 1075106002164 H-loop/switch region; other site 1075106002165 Cobalt transport protein; Region: CbiQ; cl00463 1075106002166 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106002167 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1075106002168 Walker A/P-loop; other site 1075106002169 ATP binding site [chemical binding]; other site 1075106002170 Q-loop/lid; other site 1075106002171 ABC transporter signature motif; other site 1075106002172 Walker B; other site 1075106002173 D-loop; other site 1075106002174 H-loop/switch region; other site 1075106002175 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1075106002176 FtsX-like permease family; Region: FtsX; cl15850 1075106002177 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1075106002178 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1075106002179 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1075106002180 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1075106002181 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1075106002182 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1075106002183 dimer interface [polypeptide binding]; other site 1075106002184 motif 1; other site 1075106002185 active site 1075106002186 motif 2; other site 1075106002187 motif 3; other site 1075106002188 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1075106002189 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1075106002190 putative tRNA-binding site [nucleotide binding]; other site 1075106002191 B3/4 domain; Region: B3_4; cl11458 1075106002192 tRNA synthetase B5 domain; Region: B5; cl08394 1075106002193 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1075106002194 dimer interface [polypeptide binding]; other site 1075106002195 motif 1; other site 1075106002196 motif 3; other site 1075106002197 motif 2; other site 1075106002198 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1075106002199 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1075106002200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002201 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1075106002202 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1075106002203 heterotetramer interface [polypeptide binding]; other site 1075106002204 active site pocket [active] 1075106002205 cleavage site 1075106002206 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1075106002207 feedback inhibition sensing region; other site 1075106002208 homohexameric interface [polypeptide binding]; other site 1075106002209 nucleotide binding site [chemical binding]; other site 1075106002210 N-acetyl-L-glutamate binding site [chemical binding]; other site 1075106002211 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1075106002212 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1075106002213 inhibitor-cofactor binding pocket; inhibition site 1075106002214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002215 catalytic residue [active] 1075106002216 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1075106002217 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1075106002218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002219 arginine repressor; Provisional; Region: PRK03341 1075106002220 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1075106002221 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1075106002222 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1075106002223 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1075106002224 ANP binding site [chemical binding]; other site 1075106002225 Substrate Binding Site II [chemical binding]; other site 1075106002226 Substrate Binding Site I [chemical binding]; other site 1075106002227 argininosuccinate lyase; Provisional; Region: PRK00855 1075106002228 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1075106002229 active sites [active] 1075106002230 tetramer interface [polypeptide binding]; other site 1075106002231 acetoin reductases; Region: 23BDH; TIGR02415 1075106002232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002233 NAD(P) binding site [chemical binding]; other site 1075106002234 active site 1075106002235 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1075106002236 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1075106002237 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1075106002238 active site 1075106002239 HIGH motif; other site 1075106002240 dimer interface [polypeptide binding]; other site 1075106002241 KMSKS motif; other site 1075106002242 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1075106002243 RNA binding surface [nucleotide binding]; other site 1075106002244 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1075106002245 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106002246 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106002247 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1075106002248 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1075106002249 RNA binding surface [nucleotide binding]; other site 1075106002250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106002251 Cation transport protein; Region: TrkH; cl10514 1075106002252 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1075106002253 Cation transport protein; Region: TrkH; cl10514 1075106002254 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1075106002255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002256 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1075106002257 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1075106002258 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1075106002259 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1075106002260 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1075106002261 Walker A/P-loop; other site 1075106002262 ATP binding site [chemical binding]; other site 1075106002263 Q-loop/lid; other site 1075106002264 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1075106002265 ABC transporter signature motif; other site 1075106002266 Walker B; other site 1075106002267 D-loop; other site 1075106002268 H-loop/switch region; other site 1075106002269 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1075106002270 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106002271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002272 motif II; other site 1075106002273 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 1075106002274 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1075106002275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002276 catalytic residue [active] 1075106002277 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1075106002278 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1075106002279 putative catalytic cysteine [active] 1075106002280 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1075106002281 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1075106002282 active site 1075106002283 (T/H)XGH motif; other site 1075106002284 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1075106002285 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1075106002286 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106002287 active site 1075106002288 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1075106002289 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1075106002290 Substrate binding site; other site 1075106002291 Mg++ binding site; other site 1075106002292 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1075106002293 active site 1075106002294 substrate binding site [chemical binding]; other site 1075106002295 CoA binding site [chemical binding]; other site 1075106002296 Oligomerisation domain; Region: Oligomerisation; cl00519 1075106002297 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106002298 catalytic core [active] 1075106002299 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1075106002300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106002301 catalytic core [active] 1075106002302 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1075106002303 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1075106002304 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106002305 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1075106002306 substrate binding pocket [chemical binding]; other site 1075106002307 membrane-bound complex binding site; other site 1075106002308 hinge residues; other site 1075106002309 aminoacyl-tRNA ligase; Region: PLN02563 1075106002310 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106002311 active site 1075106002312 HIGH motif; other site 1075106002313 nucleotide binding site [chemical binding]; other site 1075106002314 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106002315 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1075106002316 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106002317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106002318 active site 1075106002319 KMSKS motif; other site 1075106002320 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1075106002321 tRNA binding surface [nucleotide binding]; other site 1075106002322 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1075106002323 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1075106002324 Competence protein; Region: Competence; cl00471 1075106002325 hypothetical protein; Reviewed; Region: PRK07914 1075106002326 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1075106002327 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1075106002328 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1075106002329 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1075106002330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002331 Coenzyme A binding pocket [chemical binding]; other site 1075106002332 UGMP family protein; Validated; Region: PRK09604 1075106002333 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1075106002334 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1075106002335 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1075106002336 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1075106002337 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1075106002338 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1075106002339 phosphate binding site [ion binding]; other site 1075106002340 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1075106002341 AMP-binding enzyme; Region: AMP-binding; cl15778 1075106002342 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1075106002343 active site 1075106002344 catalytic residues [active] 1075106002345 metal binding site [ion binding]; metal-binding site 1075106002346 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1075106002347 rRNA interaction site [nucleotide binding]; other site 1075106002348 S8 interaction site; other site 1075106002349 putative laminin-1 binding site; other site 1075106002350 elongation factor Ts; Provisional; Region: tsf; PRK09377 1075106002351 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1075106002352 Elongation factor TS; Region: EF_TS; pfam00889 1075106002353 Elongation factor TS; Region: EF_TS; pfam00889 1075106002354 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1075106002355 putative nucleotide binding site [chemical binding]; other site 1075106002356 uridine monophosphate binding site [chemical binding]; other site 1075106002357 homohexameric interface [polypeptide binding]; other site 1075106002358 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1075106002359 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1075106002360 hinge region; other site 1075106002361 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1075106002362 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1075106002363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106002364 FeS/SAM binding site; other site 1075106002365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106002366 WHG domain; Region: WHG; pfam13305 1075106002367 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 1075106002368 Walker A/P-loop; other site 1075106002369 ATP binding site [chemical binding]; other site 1075106002370 ABC transporter; Region: ABC_tran; pfam00005 1075106002371 Q-loop/lid; other site 1075106002372 ABC transporter signature motif; other site 1075106002373 Walker B; other site 1075106002374 D-loop; other site 1075106002375 H-loop/switch region; other site 1075106002376 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1075106002377 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1075106002378 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1075106002379 substrate binding site [chemical binding]; other site 1075106002380 glutamase interaction surface [polypeptide binding]; other site 1075106002381 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1075106002382 anthranilate synthase component I; Provisional; Region: PRK13571 1075106002383 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1075106002384 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1075106002385 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1075106002386 putative uracil binding site [chemical binding]; other site 1075106002387 putative active site [active] 1075106002388 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 1075106002389 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1075106002390 active site 1075106002391 ribulose/triose binding site [chemical binding]; other site 1075106002392 phosphate binding site [ion binding]; other site 1075106002393 substrate (anthranilate) binding pocket [chemical binding]; other site 1075106002394 product (indole) binding pocket [chemical binding]; other site 1075106002395 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1075106002396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002397 catalytic residue [active] 1075106002398 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 1075106002399 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1075106002400 substrate binding site [chemical binding]; other site 1075106002401 active site 1075106002402 catalytic residues [active] 1075106002403 heterodimer interface [polypeptide binding]; other site 1075106002404 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1075106002405 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1075106002406 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1075106002407 substrate binding site [chemical binding]; other site 1075106002408 hexamer interface [polypeptide binding]; other site 1075106002409 metal binding site [ion binding]; metal-binding site 1075106002410 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1075106002411 homodimer interface [polypeptide binding]; other site 1075106002412 putative metal binding site [ion binding]; other site 1075106002413 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1075106002414 ATP phosphoribosyltransferase; Region: HisG; cl15266 1075106002415 HisG, C-terminal domain; Region: HisG_C; cl06867 1075106002416 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1075106002417 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1075106002418 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1075106002419 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1075106002420 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106002421 phosphopeptide binding site; other site 1075106002422 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1075106002423 DNA binding residues [nucleotide binding] 1075106002424 CrcB-like protein; Region: CRCB; cl09114 1075106002425 CrcB-like protein; Region: CRCB; cl09114 1075106002426 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1075106002427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002428 motif II; other site 1075106002429 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1075106002430 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1075106002431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106002432 ATP binding site [chemical binding]; other site 1075106002433 putative Mg++ binding site [ion binding]; other site 1075106002434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106002435 nucleotide binding region [chemical binding]; other site 1075106002436 ATP-binding site [chemical binding]; other site 1075106002437 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1075106002438 Predicted transcriptional regulator [Transcription]; Region: COG2378 1075106002439 WYL domain; Region: WYL; cl14852 1075106002440 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106002441 active site 1075106002442 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1075106002443 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002444 active site 1075106002445 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1075106002446 CMP-binding site; other site 1075106002447 The sites determining sugar specificity; other site 1075106002448 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1075106002449 G1 box; other site 1075106002450 GTP/Mg2+ binding site [chemical binding]; other site 1075106002451 Switch I region; other site 1075106002452 G2 box; other site 1075106002453 Switch II region; other site 1075106002454 G3 box; other site 1075106002455 G4 box; other site 1075106002456 G5 box; other site 1075106002457 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1075106002458 G1 box; other site 1075106002459 GTP/Mg2+ binding site [chemical binding]; other site 1075106002460 Switch I region; other site 1075106002461 G2 box; other site 1075106002462 G3 box; other site 1075106002463 Switch II region; other site 1075106002464 G4 box; other site 1075106002465 G5 box; other site 1075106002466 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1075106002467 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1075106002468 RNA binding surface [nucleotide binding]; other site 1075106002469 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1075106002470 active site 1075106002471 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1075106002472 amphipathic channel; other site 1075106002473 Asn-Pro-Ala signature motifs; other site 1075106002474 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1075106002475 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1075106002476 purine monophosphate binding site [chemical binding]; other site 1075106002477 dimer interface [polypeptide binding]; other site 1075106002478 putative catalytic residues [active] 1075106002479 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1075106002480 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1075106002481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002482 CoA-ligase; Region: Ligase_CoA; cl02894 1075106002483 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1075106002484 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1075106002485 CoA-ligase; Region: Ligase_CoA; cl02894 1075106002486 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106002487 active site 1075106002488 Preprotein translocase subunit; Region: YajC; cl00806 1075106002489 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1075106002490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106002491 Walker A motif; other site 1075106002492 ATP binding site [chemical binding]; other site 1075106002493 Walker B motif; other site 1075106002494 arginine finger; other site 1075106002495 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1075106002496 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1075106002497 RuvA N terminal domain; Region: RuvA_N; pfam01330 1075106002498 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1075106002499 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1075106002500 active site 1075106002501 putative DNA-binding cleft [nucleotide binding]; other site 1075106002502 dimer interface [polypeptide binding]; other site 1075106002503 Transcriptional regulator; Region: Transcrip_reg; cl00361 1075106002504 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1075106002505 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1075106002506 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106002507 putative acyl-acceptor binding pocket; other site 1075106002508 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1075106002509 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1075106002510 thiS-thiF/thiG interaction site; other site 1075106002511 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1075106002512 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1075106002513 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1075106002514 active site 1075106002515 dimer interface [polypeptide binding]; other site 1075106002516 motif 1; other site 1075106002517 motif 2; other site 1075106002518 motif 3; other site 1075106002519 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1075106002520 anticodon binding site; other site 1075106002521 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1075106002522 ABC transporter; Region: ABC_tran; pfam00005 1075106002523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002524 Coenzyme A binding pocket [chemical binding]; other site 1075106002525 PAC2 family; Region: PAC2; cl00847 1075106002526 Bacitracin resistance protein BacA; Region: BacA; cl00858 1075106002527 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106002528 chaperone protein DnaJ; Provisional; Region: PRK14278 1075106002529 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1075106002530 HSP70 interaction site [polypeptide binding]; other site 1075106002531 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1075106002532 Zn binding sites [ion binding]; other site 1075106002533 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1075106002534 dimer interface [polypeptide binding]; other site 1075106002535 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1075106002536 Helix-turn-helix domains; Region: HTH; cl00088 1075106002537 transketolase; Reviewed; Region: PRK05899 1075106002538 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1075106002539 TPP-binding site [chemical binding]; other site 1075106002540 dimer interface [polypeptide binding]; other site 1075106002541 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1075106002542 PYR/PP interface [polypeptide binding]; other site 1075106002543 dimer interface [polypeptide binding]; other site 1075106002544 TPP binding site [chemical binding]; other site 1075106002545 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1075106002546 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1075106002547 putative active site [active] 1075106002548 transaldolase; Provisional; Region: PRK03903 1075106002549 catalytic residue [active] 1075106002550 hypothetical protein; Validated; Region: PRK07682 1075106002551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106002552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002553 homodimer interface [polypeptide binding]; other site 1075106002554 catalytic residue [active] 1075106002555 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1075106002556 AsnC family; Region: AsnC_trans_reg; pfam01037 1075106002557 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1075106002558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1075106002559 non-specific DNA binding site [nucleotide binding]; other site 1075106002560 salt bridge; other site 1075106002561 sequence-specific DNA binding site [nucleotide binding]; other site 1075106002562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106002563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002564 homodimer interface [polypeptide binding]; other site 1075106002565 catalytic residue [active] 1075106002566 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1075106002567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002568 active site 1075106002569 motif I; other site 1075106002570 motif II; other site 1075106002571 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106002572 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1075106002573 substrate binding site [chemical binding]; other site 1075106002574 dimer interface [polypeptide binding]; other site 1075106002575 catalytic triad [active] 1075106002576 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1075106002577 Phosphoglycerate kinase; Region: PGK; pfam00162 1075106002578 substrate binding site [chemical binding]; other site 1075106002579 hinge regions; other site 1075106002580 ADP binding site [chemical binding]; other site 1075106002581 catalytic site [active] 1075106002582 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1075106002583 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1075106002584 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1075106002585 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1075106002586 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1075106002587 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1075106002588 shikimate binding site; other site 1075106002589 NAD(P) binding site [chemical binding]; other site 1075106002590 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1075106002591 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1075106002592 GIY-YIG motif/motif A; other site 1075106002593 active site 1075106002594 catalytic site [active] 1075106002595 putative DNA binding site [nucleotide binding]; other site 1075106002596 metal binding site [ion binding]; metal-binding site 1075106002597 UvrB/uvrC motif; Region: UVR; pfam02151 1075106002598 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1075106002599 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1075106002600 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1075106002601 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1075106002602 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1075106002603 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1075106002604 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1075106002605 putative active site [active] 1075106002606 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106002607 Predicted esterase [General function prediction only]; Region: COG0400 1075106002608 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1075106002609 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002610 Walker A/P-loop; other site 1075106002611 ATP binding site [chemical binding]; other site 1075106002612 Q-loop/lid; other site 1075106002613 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1075106002614 ABC transporter signature motif; other site 1075106002615 Walker B; other site 1075106002616 D-loop; other site 1075106002617 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1075106002618 Cation efflux family; Region: Cation_efflux; cl00316 1075106002619 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1075106002620 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1075106002621 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1075106002622 active site 1075106002623 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1075106002624 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1075106002625 putative substrate binding site [chemical binding]; other site 1075106002626 putative ATP binding site [chemical binding]; other site 1075106002627 peroxiredoxin; Region: AhpC; TIGR03137 1075106002628 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1075106002629 dimer interface [polypeptide binding]; other site 1075106002630 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1075106002631 catalytic triad [active] 1075106002632 peroxidatic and resolving cysteines [active] 1075106002633 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1075106002634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002635 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1075106002636 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1075106002637 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1075106002638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1075106002639 Helix-turn-helix domains; Region: HTH; cl00088 1075106002640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1075106002641 dimerization interface [polypeptide binding]; other site 1075106002642 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1075106002643 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106002644 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1075106002645 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1075106002646 Helix-turn-helix domains; Region: HTH; cl00088 1075106002647 putative acetyltransferase; Provisional; Region: PRK03624 1075106002648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002649 Coenzyme A binding pocket [chemical binding]; other site 1075106002650 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106002651 active site 1075106002652 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1075106002653 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1075106002654 heterodimer interface [polypeptide binding]; other site 1075106002655 active site 1075106002656 FMN binding site [chemical binding]; other site 1075106002657 homodimer interface [polypeptide binding]; other site 1075106002658 substrate binding site [chemical binding]; other site 1075106002659 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1075106002660 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1075106002661 FAD binding pocket [chemical binding]; other site 1075106002662 FAD binding motif [chemical binding]; other site 1075106002663 phosphate binding motif [ion binding]; other site 1075106002664 beta-alpha-beta structure motif; other site 1075106002665 NAD binding pocket [chemical binding]; other site 1075106002666 Iron coordination center [ion binding]; other site 1075106002667 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1075106002668 active site 1075106002669 dimer interface [polypeptide binding]; other site 1075106002670 dihydroorotase; Validated; Region: pyrC; PRK09357 1075106002671 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1075106002672 active site 1075106002673 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1075106002674 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1075106002675 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1075106002676 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1075106002677 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1075106002678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002679 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1075106002680 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1075106002681 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1075106002682 metal binding triad; other site 1075106002683 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1075106002684 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1075106002685 metal binding triad; other site 1075106002686 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1075106002687 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 1075106002688 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1075106002689 FAD binding site [chemical binding]; other site 1075106002690 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1075106002691 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1075106002692 THF binding site; other site 1075106002693 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1075106002694 substrate binding site [chemical binding]; other site 1075106002695 THF binding site; other site 1075106002696 zinc-binding site [ion binding]; other site 1075106002697 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106002698 catalytic core [active] 1075106002699 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1075106002700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106002701 S-adenosylmethionine binding site [chemical binding]; other site 1075106002702 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1075106002703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002704 Walker A/P-loop; other site 1075106002705 ATP binding site [chemical binding]; other site 1075106002706 Q-loop/lid; other site 1075106002707 ABC transporter signature motif; other site 1075106002708 Walker B; other site 1075106002709 D-loop; other site 1075106002710 H-loop/switch region; other site 1075106002711 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1075106002712 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1075106002713 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1075106002714 catalytic triad [active] 1075106002715 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1075106002716 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1075106002717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002718 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1075106002719 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1075106002720 active site 1075106002721 dimer interface [polypeptide binding]; other site 1075106002722 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1075106002723 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1075106002724 active site 1075106002725 FMN binding site [chemical binding]; other site 1075106002726 substrate binding site [chemical binding]; other site 1075106002727 3Fe-4S cluster binding site [ion binding]; other site 1075106002728 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1075106002729 domain interface; other site 1075106002730 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1075106002731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106002732 FeS/SAM binding site; other site 1075106002733 HemN C-terminal domain; Region: HemN_C; pfam06969 1075106002734 GTP-binding protein LepA; Provisional; Region: PRK05433 1075106002735 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1075106002736 G1 box; other site 1075106002737 putative GEF interaction site [polypeptide binding]; other site 1075106002738 GTP/Mg2+ binding site [chemical binding]; other site 1075106002739 Switch I region; other site 1075106002740 G2 box; other site 1075106002741 G3 box; other site 1075106002742 Switch II region; other site 1075106002743 G4 box; other site 1075106002744 G5 box; other site 1075106002745 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1075106002746 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1075106002747 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1075106002748 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1075106002749 UPF0126 domain; Region: UPF0126; pfam03458 1075106002750 Predicted membrane protein [Function unknown]; Region: COG2860 1075106002751 UPF0126 domain; Region: UPF0126; pfam03458 1075106002752 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1075106002753 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1075106002754 homodimer interface [polypeptide binding]; other site 1075106002755 substrate-cofactor binding pocket; other site 1075106002756 catalytic residue [active] 1075106002757 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1075106002758 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1075106002759 5S rRNA interface [nucleotide binding]; other site 1075106002760 CTC domain interface [polypeptide binding]; other site 1075106002761 L16 interface [polypeptide binding]; other site 1075106002762 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1075106002763 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106002764 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1075106002765 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1075106002766 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1075106002767 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1075106002768 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1075106002769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002770 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1075106002771 AMP-binding enzyme; Region: AMP-binding; cl15778 1075106002772 GTPase Era; Reviewed; Region: era; PRK00089 1075106002773 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1075106002774 G1 box; other site 1075106002775 GTP/Mg2+ binding site [chemical binding]; other site 1075106002776 Switch I region; other site 1075106002777 G2 box; other site 1075106002778 Switch II region; other site 1075106002779 G3 box; other site 1075106002780 G4 box; other site 1075106002781 G5 box; other site 1075106002782 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1075106002783 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1075106002784 Domain of unknown function DUF21; Region: DUF21; pfam01595 1075106002785 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1075106002786 Transporter associated domain; Region: CorC_HlyC; cl08393 1075106002787 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1075106002788 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1075106002789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002790 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1075106002791 nucleotide binding site/active site [active] 1075106002792 HIT family signature motif; other site 1075106002793 catalytic residue [active] 1075106002794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1075106002795 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1075106002796 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1075106002797 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1075106002798 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1075106002799 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1075106002800 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1075106002801 ligand binding site; other site 1075106002802 oligomer interface; other site 1075106002803 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1075106002804 dimer interface [polypeptide binding]; other site 1075106002805 N-terminal domain interface [polypeptide binding]; other site 1075106002806 sulfate 1 binding site; other site 1075106002807 Domain of unknown function DUF59; Region: DUF59; cl00941 1075106002808 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1075106002809 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1075106002810 trimerization site [polypeptide binding]; other site 1075106002811 active site 1075106002812 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1075106002813 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1075106002814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1075106002815 catalytic residue [active] 1075106002816 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1075106002817 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 1075106002818 Walker A/P-loop; other site 1075106002819 ATP binding site [chemical binding]; other site 1075106002820 Q-loop/lid; other site 1075106002821 ABC transporter signature motif; other site 1075106002822 Walker B; other site 1075106002823 D-loop; other site 1075106002824 H-loop/switch region; other site 1075106002825 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1075106002826 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1075106002827 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1075106002828 FeS assembly protein SufB; Region: sufB; TIGR01980 1075106002829 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1075106002830 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1075106002831 CTP synthetase; Validated; Region: pyrG; PRK05380 1075106002832 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1075106002833 Catalytic site [active] 1075106002834 active site 1075106002835 UTP binding site [chemical binding]; other site 1075106002836 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1075106002837 active site 1075106002838 putative oxyanion hole; other site 1075106002839 catalytic triad [active] 1075106002840 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1075106002841 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1075106002842 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1075106002843 Pullulanase 1075106002844 Pullulanase 1075106002845 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1075106002846 GIY-YIG motif/motif A; other site 1075106002847 putative active site [active] 1075106002848 putative metal binding site [ion binding]; other site 1075106002849 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1075106002850 trimer interface [polypeptide binding]; other site 1075106002851 active site 1075106002852 dimer interface [polypeptide binding]; other site 1075106002853 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1075106002854 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1075106002855 ADP binding site [chemical binding]; other site 1075106002856 magnesium binding site [ion binding]; other site 1075106002857 putative shikimate binding site; other site 1075106002858 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1075106002859 active site 1075106002860 dimer interface [polypeptide binding]; other site 1075106002861 metal binding site [ion binding]; metal-binding site 1075106002862 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1075106002863 Tetramer interface [polypeptide binding]; other site 1075106002864 active site 1075106002865 FMN-binding site [chemical binding]; other site 1075106002866 YceG-like family; Region: YceG; pfam02618 1075106002867 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 1075106002868 dimerization interface [polypeptide binding]; other site 1075106002869 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1075106002870 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1075106002871 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1075106002872 motif 1; other site 1075106002873 active site 1075106002874 motif 2; other site 1075106002875 motif 3; other site 1075106002876 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1075106002877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106002878 catalytic core [active] 1075106002879 Membrane protein of unknown function; Region: DUF360; cl00850 1075106002880 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1075106002881 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1075106002882 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1075106002883 RNA binding surface [nucleotide binding]; other site 1075106002884 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1075106002885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002886 Family description; Region: UvrD_C_2; cl15862 1075106002887 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1075106002888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1075106002889 xanthine permease; Region: pbuX; TIGR03173 1075106002890 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1075106002891 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1075106002892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106002893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002894 homodimer interface [polypeptide binding]; other site 1075106002895 catalytic residue [active] 1075106002896 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1075106002897 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1075106002898 active site 1075106002899 Na/Ca binding site [ion binding]; other site 1075106002900 catalytic site [active] 1075106002901 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1075106002902 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1075106002903 catalytic triad [active] 1075106002904 Uncharacterized conserved protein [Function unknown]; Region: COG3760 1075106002905 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1075106002906 putative deacylase active site [active] 1075106002907 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1075106002908 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1075106002909 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1075106002910 Walker A/P-loop; other site 1075106002911 ATP binding site [chemical binding]; other site 1075106002912 Q-loop/lid; other site 1075106002913 ABC transporter signature motif; other site 1075106002914 Walker B; other site 1075106002915 D-loop; other site 1075106002916 H-loop/switch region; other site 1075106002917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1075106002918 DNA-binding site [nucleotide binding]; DNA binding site 1075106002919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1075106002920 non-specific DNA binding site [nucleotide binding]; other site 1075106002921 salt bridge; other site 1075106002922 sequence-specific DNA binding site [nucleotide binding]; other site 1075106002923 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1075106002924 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1075106002925 active site 1075106002926 Chorismate mutase type II; Region: CM_2; cl00693 1075106002927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002928 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002930 Coenzyme A binding pocket [chemical binding]; other site 1075106002931 putative acetyltransferase; Provisional; Region: PRK03624 1075106002932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106002933 active site 1075106002934 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1075106002935 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1075106002936 Restriction endonuclease; Region: Mrr_cat; cl00516 1075106002937 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1075106002938 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1075106002939 G1 box; other site 1075106002940 putative GEF interaction site [polypeptide binding]; other site 1075106002941 GTP/Mg2+ binding site [chemical binding]; other site 1075106002942 Switch I region; other site 1075106002943 G2 box; other site 1075106002944 G3 box; other site 1075106002945 Switch II region; other site 1075106002946 G4 box; other site 1075106002947 G5 box; other site 1075106002948 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1075106002949 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1075106002950 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1075106002951 Transposase domain (DUF772); Region: DUF772; pfam05598 1075106002952 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1075106002953 DDE superfamily endonuclease; Region: DDE_4; cl15789 1075106002954 GMP synthase; Reviewed; Region: guaA; PRK00074 1075106002955 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1075106002956 AMP/PPi binding site [chemical binding]; other site 1075106002957 candidate oxyanion hole; other site 1075106002958 catalytic triad [active] 1075106002959 potential glutamine specificity residues [chemical binding]; other site 1075106002960 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1075106002961 ATP Binding subdomain [chemical binding]; other site 1075106002962 Ligand Binding sites [chemical binding]; other site 1075106002963 Dimerization subdomain; other site 1075106002964 putative phosphoketolase; Provisional; Region: PRK05261 1075106002965 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1075106002966 TPP-binding site; other site 1075106002967 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 1075106002968 XFP C-terminal domain; Region: XFP_C; pfam09363 1075106002969 phosphate acetyltransferase; Reviewed; Region: PRK05632 1075106002970 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1075106002971 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1075106002972 acetate kinase; Region: ackA; TIGR00016 1075106002973 Acetokinase family; Region: Acetate_kinase; cl01029 1075106002974 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1075106002975 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1075106002976 hinge; other site 1075106002977 active site 1075106002978 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1075106002979 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1075106002980 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1075106002981 active site 1075106002982 catalytic site [active] 1075106002983 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1075106002984 dimer interface [polypeptide binding]; other site 1075106002985 ADP-ribose binding site [chemical binding]; other site 1075106002986 active site 1075106002987 nudix motif; other site 1075106002988 metal binding site [ion binding]; metal-binding site 1075106002989 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1075106002990 DNA polymerase I; Provisional; Region: PRK05755 1075106002991 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1075106002992 active site 1075106002993 metal binding site 1 [ion binding]; metal-binding site 1075106002994 putative 5' ssDNA interaction site; other site 1075106002995 metal binding site 3; metal-binding site 1075106002996 metal binding site 2 [ion binding]; metal-binding site 1075106002997 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1075106002998 putative DNA binding site [nucleotide binding]; other site 1075106002999 putative metal binding site [ion binding]; other site 1075106003000 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1075106003001 active site 1075106003002 substrate binding site [chemical binding]; other site 1075106003003 catalytic site [active] 1075106003004 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1075106003005 active site 1075106003006 DNA binding site [nucleotide binding] 1075106003007 catalytic site [active] 1075106003008 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1075106003009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003010 active site 1075106003011 phosphorylation site [posttranslational modification] 1075106003012 intermolecular recognition site; other site 1075106003013 dimerization interface [polypeptide binding]; other site 1075106003014 ANTAR domain; Region: ANTAR; cl04297 1075106003015 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1075106003016 dimer interface [polypeptide binding]; other site 1075106003017 ADP-ribose binding site [chemical binding]; other site 1075106003018 active site 1075106003019 nudix motif; other site 1075106003020 metal binding site [ion binding]; metal-binding site 1075106003021 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1075106003022 pyruvate kinase; Provisional; Region: PRK05826 1075106003023 domain interfaces; other site 1075106003024 active site 1075106003025 Integral membrane protein TerC family; Region: TerC; cl10468 1075106003026 excinuclease ABC subunit B; Provisional; Region: PRK05298 1075106003027 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003029 nucleotide binding region [chemical binding]; other site 1075106003030 ATP-binding site [chemical binding]; other site 1075106003031 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1075106003032 UvrB/uvrC motif; Region: UVR; pfam02151 1075106003033 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1075106003034 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1075106003035 CoA-binding site [chemical binding]; other site 1075106003036 ATP-binding [chemical binding]; other site 1075106003037 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1075106003038 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1075106003039 RNA binding site [nucleotide binding]; other site 1075106003040 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1075106003041 RNA binding site [nucleotide binding]; other site 1075106003042 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 1075106003043 RNA binding site [nucleotide binding]; other site 1075106003044 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1075106003045 RNA binding site [nucleotide binding]; other site 1075106003046 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1075106003047 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1075106003048 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1075106003049 homodimer interface [polypeptide binding]; other site 1075106003050 NADP binding site [chemical binding]; other site 1075106003051 substrate binding site [chemical binding]; other site 1075106003052 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1075106003053 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1075106003054 intersubunit interface [polypeptide binding]; other site 1075106003055 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1075106003056 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1075106003057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1075106003058 ABC-ATPase subunit interface; other site 1075106003059 dimer interface [polypeptide binding]; other site 1075106003060 putative PBP binding regions; other site 1075106003061 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1075106003062 homotrimer interaction site [polypeptide binding]; other site 1075106003063 zinc binding site [ion binding]; other site 1075106003064 CDP-binding sites; other site 1075106003065 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1075106003066 glycogen branching enzyme; Provisional; Region: PRK05402 1075106003067 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1075106003068 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1075106003069 active site 1075106003070 catalytic site [active] 1075106003071 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1075106003072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1075106003073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003074 active site 1075106003075 phosphorylation site [posttranslational modification] 1075106003076 intermolecular recognition site; other site 1075106003077 dimerization interface [polypeptide binding]; other site 1075106003078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1075106003079 DNA binding site [nucleotide binding] 1075106003080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1075106003081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1075106003082 dimerization interface [polypeptide binding]; other site 1075106003083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1075106003084 dimer interface [polypeptide binding]; other site 1075106003085 phosphorylation site [posttranslational modification] 1075106003086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106003087 ATP binding site [chemical binding]; other site 1075106003088 Mg2+ binding site [ion binding]; other site 1075106003089 G-X-G motif; other site 1075106003090 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1075106003091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106003092 active site 1075106003093 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1075106003094 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106003095 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 1075106003096 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106003097 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1075106003098 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1075106003099 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1075106003100 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003101 Transcription factor WhiB; Region: Whib; pfam02467 1075106003102 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1075106003103 PAS fold; Region: PAS_4; pfam08448 1075106003104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1075106003105 Histidine kinase; Region: HisKA_2; cl06527 1075106003106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106003107 ATP binding site [chemical binding]; other site 1075106003108 Mg2+ binding site [ion binding]; other site 1075106003109 G-X-G motif; other site 1075106003110 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1075106003111 Haemolysin-III related; Region: HlyIII; cl03831 1075106003112 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1075106003113 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1075106003114 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1075106003115 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1075106003116 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1075106003117 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1075106003118 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1075106003119 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 1075106003120 Protein of unknown function (DUF501); Region: DUF501; cl00652 1075106003121 Septum formation initiator; Region: DivIC; cl11433 1075106003122 enolase; Provisional; Region: eno; PRK00077 1075106003123 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1075106003124 dimer interface [polypeptide binding]; other site 1075106003125 metal binding site [ion binding]; metal-binding site 1075106003126 substrate binding pocket [chemical binding]; other site 1075106003127 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1075106003128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003129 dimer interface [polypeptide binding]; other site 1075106003130 conserved gate region; other site 1075106003131 putative PBP binding loops; other site 1075106003132 ABC-ATPase subunit interface; other site 1075106003133 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1075106003134 NMT1-like family; Region: NMT1_2; cl15260 1075106003135 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1075106003136 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1075106003137 Walker A/P-loop; other site 1075106003138 ATP binding site [chemical binding]; other site 1075106003139 Q-loop/lid; other site 1075106003140 ABC transporter signature motif; other site 1075106003141 Walker B; other site 1075106003142 D-loop; other site 1075106003143 H-loop/switch region; other site 1075106003144 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1075106003145 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1075106003146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106003147 ATP binding site [chemical binding]; other site 1075106003148 putative Mg++ binding site [ion binding]; other site 1075106003149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003150 nucleotide binding region [chemical binding]; other site 1075106003151 ATP-binding site [chemical binding]; other site 1075106003152 TRCF domain; Region: TRCF; cl04088 1075106003153 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1075106003154 putative active site [active] 1075106003155 catalytic residue [active] 1075106003156 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1075106003157 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106003158 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1075106003159 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1075106003160 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1075106003161 Protein of unknown function (DUF466); Region: DUF466; cl01082 1075106003162 carbon starvation protein A; Provisional; Region: PRK15015 1075106003163 Carbon starvation protein CstA; Region: CstA; pfam02554 1075106003164 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1075106003165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003166 D-loop; other site 1075106003167 H-loop/switch region; other site 1075106003168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003169 ABC transporter signature motif; other site 1075106003170 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 1075106003171 Q-loop/lid; other site 1075106003172 ABC transporter signature motif; other site 1075106003173 Walker B; other site 1075106003174 D-loop; other site 1075106003175 H-loop/switch region; other site 1075106003176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1075106003177 Helix-turn-helix domains; Region: HTH; cl00088 1075106003178 Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075 1075106003179 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 1075106003180 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1075106003181 Aspartase; Region: Aspartase; cd01357 1075106003182 active sites [active] 1075106003183 tetramer interface [polypeptide binding]; other site 1075106003184 FeoA domain; Region: FeoA; cl00838 1075106003185 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1075106003186 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1075106003187 G1 box; other site 1075106003188 GTP/Mg2+ binding site [chemical binding]; other site 1075106003189 Switch I region; other site 1075106003190 G2 box; other site 1075106003191 G3 box; other site 1075106003192 Switch II region; other site 1075106003193 G4 box; other site 1075106003194 G5 box; other site 1075106003195 Nucleoside recognition; Region: Gate; cl00486 1075106003196 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1075106003197 Nucleoside recognition; Region: Gate; cl00486 1075106003198 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1075106003199 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1075106003200 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1075106003201 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1075106003202 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1075106003203 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1075106003204 putative active site [active] 1075106003205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003206 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1075106003207 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1075106003208 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1075106003209 catalytic triad [active] 1075106003210 active site nucleophile [active] 1075106003211 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1075106003212 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1075106003213 SelR domain; Region: SelR; pfam01641 1075106003214 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1075106003215 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1075106003216 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1075106003217 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106003218 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106003219 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1075106003220 classical (c) SDRs; Region: SDR_c; cd05233 1075106003221 NAD(P) binding site [chemical binding]; other site 1075106003222 active site 1075106003223 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1075106003224 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1075106003225 ATP binding site [chemical binding]; other site 1075106003226 Mg++ binding site [ion binding]; other site 1075106003227 motif III; other site 1075106003228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003229 nucleotide binding region [chemical binding]; other site 1075106003230 ATP-binding site [chemical binding]; other site 1075106003231 transcription termination factor Rho; Provisional; Region: PRK12678 1075106003232 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1075106003233 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1075106003234 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1075106003235 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106003236 substrate binding pocket [chemical binding]; other site 1075106003237 Cupin domain; Region: Cupin_2; cl09118 1075106003238 GTP-binding protein YchF; Reviewed; Region: PRK09601 1075106003239 YchF GTPase; Region: YchF; cd01900 1075106003240 G1 box; other site 1075106003241 GTP/Mg2+ binding site [chemical binding]; other site 1075106003242 Switch I region; other site 1075106003243 G2 box; other site 1075106003244 Switch II region; other site 1075106003245 G3 box; other site 1075106003246 G4 box; other site 1075106003247 G5 box; other site 1075106003248 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1075106003249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003250 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1075106003251 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1075106003252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106003253 Histidine kinase; Region: HisKA_3; pfam07730 1075106003254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1075106003255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106003256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003257 active site 1075106003258 phosphorylation site [posttranslational modification] 1075106003259 intermolecular recognition site; other site 1075106003260 dimerization interface [polypeptide binding]; other site 1075106003261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106003262 DNA binding residues [nucleotide binding] 1075106003263 dimerization interface [polypeptide binding]; other site 1075106003264 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106003265 FtsX-like permease family; Region: FtsX; cl15850 1075106003266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106003267 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1075106003268 Walker A/P-loop; other site 1075106003269 ATP binding site [chemical binding]; other site 1075106003270 Q-loop/lid; other site 1075106003271 ABC transporter signature motif; other site 1075106003272 Walker B; other site 1075106003273 D-loop; other site 1075106003274 H-loop/switch region; other site 1075106003275 potential frameshift: common BLAST hit: gi|241196492|ref|YP_002970047.1| cobalt transport protein 1075106003276 Cobalt transport protein; Region: CbiQ; cl00463 1075106003277 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106003278 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106003279 Walker A/P-loop; other site 1075106003280 ATP binding site [chemical binding]; other site 1075106003281 Q-loop/lid; other site 1075106003282 ABC transporter signature motif; other site 1075106003283 Walker B; other site 1075106003284 D-loop; other site 1075106003285 H-loop/switch region; other site 1075106003286 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106003287 Walker A/P-loop; other site 1075106003288 ATP binding site [chemical binding]; other site 1075106003289 Q-loop/lid; other site 1075106003290 ABC transporter signature motif; other site 1075106003291 Walker B; other site 1075106003292 D-loop; other site 1075106003293 H-loop/switch region; other site 1075106003294 putative methionine aminopeptidase 1075106003295 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1075106003296 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1075106003297 homodimer interface [polypeptide binding]; other site 1075106003298 substrate-cofactor binding pocket; other site 1075106003299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106003300 catalytic residue [active] 1075106003301 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1075106003302 dimer interface [polypeptide binding]; other site 1075106003303 pyridoxal binding site [chemical binding]; other site 1075106003304 ATP binding site [chemical binding]; other site 1075106003305 Restriction endonuclease; Region: Mrr_cat; cl00516 1075106003306 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1075106003307 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1075106003308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106003309 Walker A motif; other site 1075106003310 ATP binding site [chemical binding]; other site 1075106003311 Walker B motif; other site 1075106003312 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1075106003313 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1075106003314 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1075106003315 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1075106003316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003317 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1075106003318 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1075106003319 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1075106003320 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1075106003321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106003322 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1075106003323 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1075106003324 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1075106003325 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106003326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106003327 homodimer interface [polypeptide binding]; other site 1075106003328 catalytic residue [active] 1075106003329 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1075106003330 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1075106003331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106003332 Walker A motif; other site 1075106003333 ATP binding site [chemical binding]; other site 1075106003334 Walker B motif; other site 1075106003335 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1075106003336 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1075106003337 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1075106003338 oligomer interface [polypeptide binding]; other site 1075106003339 active site residues [active] 1075106003340 Clp protease; Region: CLP_protease; pfam00574 1075106003341 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1075106003342 oligomer interface [polypeptide binding]; other site 1075106003343 active site residues [active] 1075106003344 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1075106003345 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 1075106003346 putative ion selectivity filter; other site 1075106003347 putative pore gating glutamate residue; other site 1075106003348 trigger factor; Provisional; Region: tig; PRK01490 1075106003349 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1075106003350 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1075106003351 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1075106003352 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1075106003353 active site 1075106003354 catalytic site [active] 1075106003355 substrate binding site [chemical binding]; other site 1075106003356 HRDC domain; Region: HRDC; cl02578 1075106003357 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1075106003358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106003359 FeS/SAM binding site; other site 1075106003360 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1075106003361 Pyruvate formate lyase 1; Region: PFL1; cd01678 1075106003362 coenzyme A binding site [chemical binding]; other site 1075106003363 active site 1075106003364 catalytic residues [active] 1075106003365 glycine loop; other site 1075106003366 NAD synthetase; Provisional; Region: PRK13981 1075106003367 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1075106003368 multimer interface [polypeptide binding]; other site 1075106003369 active site 1075106003370 catalytic triad [active] 1075106003371 protein interface 1 [polypeptide binding]; other site 1075106003372 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1075106003373 homodimer interface [polypeptide binding]; other site 1075106003374 NAD binding pocket [chemical binding]; other site 1075106003375 ATP binding pocket [chemical binding]; other site 1075106003376 Mg binding site [ion binding]; other site 1075106003377 active-site loop [active] 1075106003378 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1075106003379 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1075106003380 metal binding site [ion binding]; metal-binding site 1075106003381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1075106003382 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1075106003383 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1075106003384 Walker A/P-loop; other site 1075106003385 ATP binding site [chemical binding]; other site 1075106003386 Q-loop/lid; other site 1075106003387 ABC transporter signature motif; other site 1075106003388 Walker B; other site 1075106003389 D-loop; other site 1075106003390 H-loop/switch region; other site 1075106003391 NIL domain; Region: NIL; cl09633 1075106003392 NMT1-like family; Region: NMT1_2; cl15260 1075106003393 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 1075106003394 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1075106003395 active site 1075106003396 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1075106003397 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1075106003398 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1075106003399 synthetase active site [active] 1075106003400 NTP binding site [chemical binding]; other site 1075106003401 metal binding site [ion binding]; metal-binding site 1075106003402 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1075106003403 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1075106003404 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1075106003405 trimer interface [polypeptide binding]; other site 1075106003406 active site 1075106003407 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1075106003408 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1075106003409 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1075106003410 Sulfatase; Region: Sulfatase; cl10460 1075106003411 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1075106003412 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1075106003413 CAP-like domain; other site 1075106003414 active site 1075106003415 primary dimer interface [polypeptide binding]; other site 1075106003416 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1075106003417 EamA-like transporter family; Region: EamA; cl01037 1075106003418 Sugar transport protein; Region: Sugar_transport; pfam06800 1075106003419 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1075106003420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106003421 ATP binding site [chemical binding]; other site 1075106003422 putative Mg++ binding site [ion binding]; other site 1075106003423 ATP-dependent helicase; Provisional; Region: PRK13767 1075106003424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003425 nucleotide binding region [chemical binding]; other site 1075106003426 ATP-binding site [chemical binding]; other site 1075106003427 DEAD/H associated; Region: DEAD_assoc; pfam08494 1075106003428 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1075106003429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106003430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106003431 putative substrate translocation pore; other site 1075106003432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1075106003433 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1075106003434 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1075106003435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106003436 ATP binding site [chemical binding]; other site 1075106003437 Mg2+ binding site [ion binding]; other site 1075106003438 G-X-G motif; other site 1075106003439 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1075106003440 anchoring element; other site 1075106003441 dimer interface [polypeptide binding]; other site 1075106003442 ATP binding site [chemical binding]; other site 1075106003443 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1075106003444 active site 1075106003445 putative metal-binding site [ion binding]; other site 1075106003446 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1075106003447 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1075106003448 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1075106003449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1075106003450 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1075106003451 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1075106003452 DNA binding residues [nucleotide binding] 1075106003453 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1075106003454 substrate binding pocket [chemical binding]; other site 1075106003455 chain length determination region; other site 1075106003456 substrate-Mg2+ binding site; other site 1075106003457 catalytic residues [active] 1075106003458 aspartate-rich region 1; other site 1075106003459 active site lid residues [active] 1075106003460 aspartate-rich region 2; other site 1075106003461 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106003462 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1075106003463 active site 1075106003464 ATP binding site [chemical binding]; other site 1075106003465 substrate binding site [chemical binding]; other site 1075106003466 activation loop (A-loop); other site 1075106003467 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106003468 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106003469 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106003470 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1075106003471 putative acyl-acceptor binding pocket; other site 1075106003472 DoxX; Region: DoxX; cl00976 1075106003473 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1075106003474 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1075106003475 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1075106003476 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1075106003477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003478 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1075106003479 hypothetical protein; Provisional; Region: PRK05590 1075106003480 SEC-C motif; Region: SEC-C; pfam02810 1075106003481 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1075106003482 30S subunit binding site; other site 1075106003483 RecX family; Region: RecX; cl00936 1075106003484 recombinase A; Provisional; Region: recA; PRK09354 1075106003485 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1075106003486 hexamer interface [polypeptide binding]; other site 1075106003487 Walker A motif; other site 1075106003488 ATP binding site [chemical binding]; other site 1075106003489 Walker B motif; other site 1075106003490 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1075106003491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1075106003492 Competence-damaged protein; Region: CinA; cl00666 1075106003493 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1075106003494 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003495 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1075106003496 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003497 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1075106003498 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1075106003499 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1075106003500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106003501 FeS/SAM binding site; other site 1075106003502 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1075106003503 synthetase active site [active] 1075106003504 NTP binding site [chemical binding]; other site 1075106003505 metal binding site [ion binding]; metal-binding site 1075106003506 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1075106003507 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1075106003508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003509 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1075106003510 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1075106003511 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1075106003512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003513 Walker A/P-loop; other site 1075106003514 ATP binding site [chemical binding]; other site 1075106003515 Q-loop/lid; other site 1075106003516 ABC transporter signature motif; other site 1075106003517 Walker B; other site 1075106003518 D-loop; other site 1075106003519 H-loop/switch region; other site 1075106003520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106003521 Histidine kinase; Region: HisKA_3; pfam07730 1075106003522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106003523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003524 active site 1075106003525 phosphorylation site [posttranslational modification] 1075106003526 intermolecular recognition site; other site 1075106003527 dimerization interface [polypeptide binding]; other site 1075106003528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106003529 DNA binding residues [nucleotide binding] 1075106003530 dimerization interface [polypeptide binding]; other site 1075106003531 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106003532 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106003533 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1075106003534 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1075106003535 active site 1075106003536 catalytic site [active] 1075106003537 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1075106003538 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1075106003539 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1075106003540 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106003541 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106003542 Protein of unknown function DUF262; Region: DUF262; cl14890 1075106003543 maltose O-acetyltransferase; Provisional; Region: PRK10092 1075106003544 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1075106003545 active site 1075106003546 substrate binding site [chemical binding]; other site 1075106003547 trimer interface [polypeptide binding]; other site 1075106003548 CoA binding site [chemical binding]; other site 1075106003549 aconitate hydratase; Validated; Region: PRK09277 1075106003550 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1075106003551 substrate binding site [chemical binding]; other site 1075106003552 ligand binding site [chemical binding]; other site 1075106003553 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1075106003554 substrate binding site [chemical binding]; other site 1075106003555 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1075106003556 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106003557 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106003558 Protein of unknown function (DUF418); Region: DUF418; cl12135 1075106003559 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1075106003560 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1075106003561 TRAM domain; Region: TRAM; cl01282 1075106003562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106003563 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1075106003564 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1075106003565 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1075106003566 putative active site [active] 1075106003567 putative catalytic site [active] 1075106003568 putative DNA binding site [nucleotide binding]; other site 1075106003569 putative phosphate binding site [ion binding]; other site 1075106003570 metal binding site A [ion binding]; metal-binding site 1075106003571 putative AP binding site [nucleotide binding]; other site 1075106003572 putative metal binding site B [ion binding]; other site 1075106003573 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1075106003574 AAA domain; Region: AAA_21; pfam13304 1075106003575 Walker A/P-loop; other site 1075106003576 ATP binding site [chemical binding]; other site 1075106003577 Q-loop/lid; other site 1075106003578 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1075106003579 ABC transporter signature motif; other site 1075106003580 Walker B; other site 1075106003581 D-loop; other site 1075106003582 H-loop/switch region; other site 1075106003583 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106003584 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1075106003585 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1075106003586 Walker A/P-loop; other site 1075106003587 ATP binding site [chemical binding]; other site 1075106003588 Q-loop/lid; other site 1075106003589 ABC transporter signature motif; other site 1075106003590 Walker B; other site 1075106003591 D-loop; other site 1075106003592 H-loop/switch region; other site 1075106003593 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1075106003594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003595 dimer interface [polypeptide binding]; other site 1075106003596 conserved gate region; other site 1075106003597 putative PBP binding loops; other site 1075106003598 ABC-ATPase subunit interface; other site 1075106003599 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1075106003600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003601 dimer interface [polypeptide binding]; other site 1075106003602 conserved gate region; other site 1075106003603 putative PBP binding loops; other site 1075106003604 ABC-ATPase subunit interface; other site 1075106003605 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1075106003606 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1075106003607 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1075106003608 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1075106003609 active site 1075106003610 DNA binding site [nucleotide binding] 1075106003611 Int/Topo IB signature motif; other site 1075106003612 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106003613 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1075106003614 Walker A/P-loop; other site 1075106003615 ATP binding site [chemical binding]; other site 1075106003616 Q-loop/lid; other site 1075106003617 ABC transporter signature motif; other site 1075106003618 Walker B; other site 1075106003619 D-loop; other site 1075106003620 H-loop/switch region; other site 1075106003621 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106003622 FtsX-like permease family; Region: FtsX; cl15850 1075106003623 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106003624 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1075106003625 FtsX-like permease family; Region: FtsX; cl15850 1075106003626 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1075106003627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003628 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1075106003629 Prephenate dehydratase; Region: PDT; pfam00800 1075106003630 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1075106003631 putative L-Phe binding site [chemical binding]; other site 1075106003632 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1075106003633 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1075106003634 G1 box; other site 1075106003635 putative GEF interaction site [polypeptide binding]; other site 1075106003636 GTP/Mg2+ binding site [chemical binding]; other site 1075106003637 Switch I region; other site 1075106003638 G2 box; other site 1075106003639 G3 box; other site 1075106003640 Switch II region; other site 1075106003641 G4 box; other site 1075106003642 G5 box; other site 1075106003643 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1075106003644 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1075106003645 benzoate transport; Region: 2A0115; TIGR00895 1075106003646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106003647 putative substrate translocation pore; other site 1075106003648 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1075106003649 nudix motif; other site 1075106003650 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1075106003651 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1075106003652 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1075106003653 P-loop; other site 1075106003654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003655 Magnesium ion binding site [ion binding]; other site 1075106003656 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1075106003657 Magnesium ion binding site [ion binding]; other site 1075106003658 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1075106003659 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1075106003660 active site 1075106003661 Int/Topo IB signature motif; other site 1075106003662 ribosomal protein L20; Region: rpl20; CHL00068 1075106003663 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1075106003664 23S rRNA binding site [nucleotide binding]; other site 1075106003665 L21 binding site [polypeptide binding]; other site 1075106003666 L13 binding site [polypeptide binding]; other site 1075106003667 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 1075106003668 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1075106003669 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1075106003670 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1075106003671 Thiamine pyrophosphokinase; Region: TPK; cd07995 1075106003672 active site 1075106003673 dimerization interface [polypeptide binding]; other site 1075106003674 thiamine binding site [chemical binding]; other site 1075106003675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003676 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1075106003677 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1075106003678 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1075106003679 putative deacylase active site [active] 1075106003680 LytB protein; Region: LYTB; cl00507 1075106003681 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1075106003682 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1075106003683 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1075106003684 active site 1075106003685 catalytic residues [active] 1075106003686 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1075106003687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1075106003688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1075106003689 DNA binding residues [nucleotide binding] 1075106003690 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1075106003691 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1075106003692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003694 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106003695 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106003696 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1075106003697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003698 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003699 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106003700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003701 active site 1075106003702 phosphorylation site [posttranslational modification] 1075106003703 intermolecular recognition site; other site 1075106003704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106003705 DNA binding residues [nucleotide binding] 1075106003706 dimerization interface [polypeptide binding]; other site 1075106003707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106003708 Histidine kinase; Region: HisKA_3; pfam07730 1075106003709 proline aminopeptidase P II; Provisional; Region: PRK10879 1075106003710 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 1075106003711 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1075106003712 active site 1075106003713 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1075106003714 nudix motif; other site 1075106003715 Helix-turn-helix domains; Region: HTH; cl00088 1075106003716 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106003717 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1075106003718 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1075106003719 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1075106003720 putative substrate binding site [chemical binding]; other site 1075106003721 putative ATP binding site [chemical binding]; other site 1075106003722 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1075106003723 putative active site [active] 1075106003724 dimerization interface [polypeptide binding]; other site 1075106003725 putative tRNAtyr binding site [nucleotide binding]; other site 1075106003726 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1075106003727 active site 1075106003728 DNA binding site [nucleotide binding] 1075106003729 Int/Topo IB signature motif; other site 1075106003730 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1075106003731 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1075106003732 AAA domain; Region: AAA_25; pfam13481 1075106003733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003734 Walker A motif; other site 1075106003735 ATP binding site [chemical binding]; other site 1075106003736 Walker B motif; other site 1075106003737 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1075106003738 Phage capsid family; Region: Phage_capsid; pfam05065 1075106003739 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106003740 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1075106003741 Walker A/P-loop; other site 1075106003742 ATP binding site [chemical binding]; other site 1075106003743 Q-loop/lid; other site 1075106003744 ABC transporter signature motif; other site 1075106003745 Walker B; other site 1075106003746 D-loop; other site 1075106003747 H-loop/switch region; other site 1075106003748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106003749 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1075106003750 Walker A/P-loop; other site 1075106003751 ATP binding site [chemical binding]; other site 1075106003752 Q-loop/lid; other site 1075106003753 ABC transporter signature motif; other site 1075106003754 Walker B; other site 1075106003755 D-loop; other site 1075106003756 H-loop/switch region; other site 1075106003757 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106003758 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1075106003759 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1075106003760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003761 dimer interface [polypeptide binding]; other site 1075106003762 conserved gate region; other site 1075106003763 ABC-ATPase subunit interface; other site 1075106003764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003765 dimer interface [polypeptide binding]; other site 1075106003766 conserved gate region; other site 1075106003767 putative PBP binding loops; other site 1075106003768 ABC-ATPase subunit interface; other site 1075106003769 ABC transporter substrate-binding protein 1075106003770 ABC transporter substrate-binding protein 1075106003771 cell division protein FtsQ; Provisional; Region: PRK05529 1075106003772 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1075106003773 Cell division protein FtsQ; Region: FtsQ; pfam03799 1075106003774 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1075106003775 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1075106003776 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003777 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003778 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1075106003779 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1075106003780 active site 1075106003781 homodimer interface [polypeptide binding]; other site 1075106003782 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1075106003783 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1075106003784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003785 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003786 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003787 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1075106003788 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1075106003789 Mg++ binding site [ion binding]; other site 1075106003790 putative catalytic motif [active] 1075106003791 putative substrate binding site [chemical binding]; other site 1075106003792 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1075106003793 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1075106003794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003796 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 1075106003797 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1075106003798 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1075106003799 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1075106003800 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1075106003801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106003802 MraZ protein; Region: MraZ; pfam02381 1075106003803 cell division protein MraZ; Reviewed; Region: PRK00326 1075106003804 MraZ protein; Region: MraZ; pfam02381 1075106003805 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1075106003806 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003807 Family description; Region: UvrD_C_2; cl15862 1075106003808 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1075106003809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003810 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1075106003811 L-serine binding site [chemical binding]; other site 1075106003812 ACT domain interface; other site 1075106003813 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1075106003814 ATP cone domain; Region: ATP-cone; pfam03477 1075106003815 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1075106003816 LexA repressor; Validated; Region: PRK00215 1075106003817 Helix-turn-helix domains; Region: HTH; cl00088 1075106003818 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1075106003819 Catalytic site [active] 1075106003820 Cation efflux family; Region: Cation_efflux; cl00316 1075106003821 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1075106003822 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1075106003823 NAD binding site [chemical binding]; other site 1075106003824 dimer interface [polypeptide binding]; other site 1075106003825 substrate binding site [chemical binding]; other site 1075106003826 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106003827 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1075106003828 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1075106003829 HflX GTPase family; Region: HflX; cd01878 1075106003830 G1 box; other site 1075106003831 GTP/Mg2+ binding site [chemical binding]; other site 1075106003832 Switch I region; other site 1075106003833 G2 box; other site 1075106003834 G3 box; other site 1075106003835 Switch II region; other site 1075106003836 G4 box; other site 1075106003837 G5 box; other site 1075106003838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106003839 S-adenosylmethionine binding site [chemical binding]; other site 1075106003840 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1075106003841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106003842 ATP binding site [chemical binding]; other site 1075106003843 putative Mg++ binding site [ion binding]; other site 1075106003844 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003845 nucleotide binding region [chemical binding]; other site 1075106003846 ATP-binding site [chemical binding]; other site 1075106003847 Helicase associated domain (HA2); Region: HA2; cl04503 1075106003848 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1075106003849 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1075106003850 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1075106003851 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1075106003852 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1075106003853 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1075106003854 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 1075106003855 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1075106003856 catalytic residues [active] 1075106003857 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1075106003858 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1075106003859 putative active site [active] 1075106003860 oxyanion strand; other site 1075106003861 catalytic triad [active] 1075106003862 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 1075106003863 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1075106003864 putative active site pocket [active] 1075106003865 4-fold oligomerization interface [polypeptide binding]; other site 1075106003866 metal binding residues [ion binding]; metal-binding site 1075106003867 3-fold/trimer interface [polypeptide binding]; other site 1075106003868 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1075106003869 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106003870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106003871 homodimer interface [polypeptide binding]; other site 1075106003872 catalytic residue [active] 1075106003873 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1075106003874 histidinol dehydrogenase; Region: hisD; TIGR00069 1075106003875 NAD binding site [chemical binding]; other site 1075106003876 dimerization interface [polypeptide binding]; other site 1075106003877 product binding site; other site 1075106003878 substrate binding site [chemical binding]; other site 1075106003879 zinc binding site [ion binding]; other site 1075106003880 catalytic residues [active] 1075106003881 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1075106003882 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1075106003883 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1075106003884 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1075106003885 generic binding surface I; other site 1075106003886 generic binding surface II; other site 1075106003887 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1075106003888 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1075106003889 RNA binding surface [nucleotide binding]; other site 1075106003890 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1075106003891 active site 1075106003892 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1075106003893 DivIVA protein; Region: DivIVA; pfam05103 1075106003894 DivIVA domain; Region: DivI1A_domain; TIGR03544 1075106003895 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1075106003896 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 1075106003897 YGGT family; Region: YGGT; cl00508 1075106003898 Protein of unknown function (DUF552); Region: DUF552; cl00775 1075106003899 cell division protein FtsZ; Validated; Region: PRK09330 1075106003900 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1075106003901 nucleotide binding site [chemical binding]; other site 1075106003902 SulA interaction site; other site 1075106003903 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1075106003904 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1075106003905 FMN binding site [chemical binding]; other site 1075106003906 active site 1075106003907 catalytic residues [active] 1075106003908 substrate binding site [chemical binding]; other site 1075106003909 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1075106003910 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1075106003911 motif 1; other site 1075106003912 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 1075106003913 active site 1075106003914 motif 2; other site 1075106003915 motif 3; other site 1075106003916 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1075106003917 anticodon binding site; other site 1075106003918 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1075106003919 substrate binding site [chemical binding]; other site 1075106003920 multimerization interface [polypeptide binding]; other site 1075106003921 ATP binding site [chemical binding]; other site 1075106003922 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1075106003923 thiamine phosphate binding site [chemical binding]; other site 1075106003924 active site 1075106003925 pyrophosphate binding site [ion binding]; other site 1075106003926 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1075106003927 substrate binding site [chemical binding]; other site 1075106003928 dimer interface [polypeptide binding]; other site 1075106003929 ATP binding site [chemical binding]; other site 1075106003930 Domain of unknown function DUF77; Region: DUF77; cl00307 1075106003931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106003932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106003933 DNA binding site [nucleotide binding] 1075106003934 domain linker motif; other site 1075106003935 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1075106003936 putative dimerization interface [polypeptide binding]; other site 1075106003937 putative ligand binding site [chemical binding]; other site 1075106003938 galactoside permease; Reviewed; Region: lacY; PRK09528 1075106003939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106003940 putative substrate translocation pore; other site 1075106003941 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1075106003942 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1075106003943 substrate binding [chemical binding]; other site 1075106003944 active site 1075106003945 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1075106003946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1075106003947 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1075106003948 NMT1/THI5 like; Region: NMT1; pfam09084 1075106003949 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1075106003950 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1075106003951 active site 1075106003952 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1075106003953 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1075106003954 catalytic residue [active] 1075106003955 putative FPP diphosphate binding site; other site 1075106003956 putative FPP binding hydrophobic cleft; other site 1075106003957 dimer interface [polypeptide binding]; other site 1075106003958 putative IPP diphosphate binding site; other site 1075106003959 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1075106003960 Recombination protein O N terminal; Region: RecO_N; cl15812 1075106003961 Recombination protein O C terminal; Region: RecO_C; pfam02565 1075106003962 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1075106003963 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1075106003964 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1075106003965 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1075106003966 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1075106003967 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1075106003968 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1075106003969 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1075106003970 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1075106003971 DivIVA domain; Region: DivI1A_domain; TIGR03544 1075106003972 DivIVA domain; Region: DivI1A_domain; TIGR03544 1075106003973 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1075106003974 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1075106003975 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1075106003976 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 1075106003977 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1075106003978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106003979 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1075106003980 Family description; Region: UvrD_C_2; cl15862 1075106003981 Phosphotransferase enzyme family; Region: APH; pfam01636 1075106003982 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106003983 substrate binding site [chemical binding]; other site 1075106003984 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1075106003985 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1075106003986 Vitamin K epoxide reductase family; Region: VKOR; cl01729 1075106003987 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1075106003988 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1075106003989 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1075106003990 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1075106003991 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1075106003992 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1075106003993 active site 1075106003994 nucleophile elbow; other site 1075106003995 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1075106003996 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1075106003997 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1075106003998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106003999 substrate binding pocket [chemical binding]; other site 1075106004000 membrane-bound complex binding site; other site 1075106004001 hinge residues; other site 1075106004002 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1075106004003 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004004 Walker A/P-loop; other site 1075106004005 ATP binding site [chemical binding]; other site 1075106004006 Q-loop/lid; other site 1075106004007 ABC transporter signature motif; other site 1075106004008 Walker B; other site 1075106004009 D-loop; other site 1075106004010 H-loop/switch region; other site 1075106004011 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1075106004012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004013 dimer interface [polypeptide binding]; other site 1075106004014 conserved gate region; other site 1075106004015 putative PBP binding loops; other site 1075106004016 ABC-ATPase subunit interface; other site 1075106004017 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1075106004018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004019 dimer interface [polypeptide binding]; other site 1075106004020 conserved gate region; other site 1075106004021 putative PBP binding loops; other site 1075106004022 ABC-ATPase subunit interface; other site 1075106004023 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1075106004024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106004025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106004026 homodimer interface [polypeptide binding]; other site 1075106004027 catalytic residue [active] 1075106004028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004029 putative PBP binding loops; other site 1075106004030 ABC-ATPase subunit interface; other site 1075106004031 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1075106004032 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1075106004033 Walker A/P-loop; other site 1075106004034 ATP binding site [chemical binding]; other site 1075106004035 Q-loop/lid; other site 1075106004036 ABC transporter signature motif; other site 1075106004037 Walker B; other site 1075106004038 D-loop; other site 1075106004039 H-loop/switch region; other site 1075106004040 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106004041 NIL domain; Region: NIL; cl09633 1075106004042 NMT1-like family; Region: NMT1_2; cl15260 1075106004043 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1075106004044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004045 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1075106004046 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106004047 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1075106004048 active site 1075106004049 catalytic site [active] 1075106004050 substrate binding site [chemical binding]; other site 1075106004051 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1075106004052 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1075106004053 G1 box; other site 1075106004054 putative GEF interaction site [polypeptide binding]; other site 1075106004055 GTP/Mg2+ binding site [chemical binding]; other site 1075106004056 Switch I region; other site 1075106004057 G2 box; other site 1075106004058 G3 box; other site 1075106004059 Switch II region; other site 1075106004060 G4 box; other site 1075106004061 G5 box; other site 1075106004062 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1075106004063 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1075106004064 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1075106004065 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1075106004066 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1075106004067 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1075106004068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004069 putative substrate translocation pore; other site 1075106004070 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1075106004071 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1075106004072 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1075106004073 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1075106004074 HIGH motif; other site 1075106004075 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1075106004076 active site 1075106004077 KMSKS motif; other site 1075106004078 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1075106004079 tRNA binding surface [nucleotide binding]; other site 1075106004080 anticodon binding site; other site 1075106004081 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1075106004082 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1075106004083 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1075106004084 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1075106004085 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1075106004086 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1075106004087 Walker A/P-loop; other site 1075106004088 ATP binding site [chemical binding]; other site 1075106004089 Q-loop/lid; other site 1075106004090 ABC transporter signature motif; other site 1075106004091 Walker B; other site 1075106004092 D-loop; other site 1075106004093 H-loop/switch region; other site 1075106004094 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1075106004095 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004097 Walker A/P-loop; other site 1075106004098 ATP binding site [chemical binding]; other site 1075106004099 Q-loop/lid; other site 1075106004100 ABC transporter signature motif; other site 1075106004101 Walker B; other site 1075106004102 D-loop; other site 1075106004103 H-loop/switch region; other site 1075106004104 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1075106004105 Helix-turn-helix domains; Region: HTH; cl00088 1075106004106 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1075106004107 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1075106004108 additional DNA contacts [nucleotide binding]; other site 1075106004109 mismatch recognition site; other site 1075106004110 active site 1075106004111 zinc binding site [ion binding]; other site 1075106004112 DNA intercalation site [nucleotide binding]; other site 1075106004113 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1075106004114 FIC domain binding interface [polypeptide binding]; other site 1075106004115 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 1075106004116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004118 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1075106004119 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1075106004120 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1075106004121 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1075106004122 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1075106004123 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1075106004124 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1075106004125 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1075106004126 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1075106004127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1075106004128 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 1075106004129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1075106004130 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1075106004131 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 1075106004132 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1075106004133 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1075106004134 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1075106004135 ATP cone domain; Region: ATP-cone; pfam03477 1075106004136 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1075106004137 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1075106004138 active site 1075106004139 Zn binding site [ion binding]; other site 1075106004140 glycine loop; other site 1075106004141 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1075106004142 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1075106004143 generic binding surface II; other site 1075106004144 generic binding surface I; other site 1075106004145 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1075106004146 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1075106004147 putative catalytic site [active] 1075106004148 putative metal binding site [ion binding]; other site 1075106004149 putative phosphate binding site [ion binding]; other site 1075106004150 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1075106004151 aminotransferase; Validated; Region: PRK07337 1075106004152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106004153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106004154 homodimer interface [polypeptide binding]; other site 1075106004155 catalytic residue [active] 1075106004156 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1075106004157 additional DNA contacts [nucleotide binding]; other site 1075106004158 mismatch recognition site; other site 1075106004159 active site 1075106004160 zinc binding site [ion binding]; other site 1075106004161 DNA intercalation site [nucleotide binding]; other site 1075106004162 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1075106004163 active site 1075106004164 catalytic site [active] 1075106004165 substrate binding site [chemical binding]; other site 1075106004166 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1075106004167 active site 1075106004168 catalytic residues [active] 1075106004169 metal binding site [ion binding]; metal-binding site 1075106004170 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1075106004171 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1075106004172 active site 1075106004173 substrate binding site [chemical binding]; other site 1075106004174 metal binding site [ion binding]; metal-binding site 1075106004175 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1075106004176 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1075106004177 Zn binding site [ion binding]; other site 1075106004178 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1075106004179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1075106004180 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1075106004181 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1075106004182 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1075106004183 dimer interface [polypeptide binding]; other site 1075106004184 active site 1075106004185 catalytic residue [active] 1075106004186 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1075106004187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004188 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1075106004189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106004190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004191 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106004192 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1075106004193 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1075106004194 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1075106004195 Family description; Region: UvrD_C_2; cl15862 1075106004196 DNA helicase IV; Provisional; Region: helD; PRK11054 1075106004197 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1075106004198 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1075106004199 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1075106004200 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106004201 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1075106004202 active site 1075106004203 ATP binding site [chemical binding]; other site 1075106004204 substrate binding site [chemical binding]; other site 1075106004205 activation loop (A-loop); other site 1075106004206 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1075106004207 Interdomain contacts; other site 1075106004208 Cytokine receptor motif; other site 1075106004209 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1075106004210 Interdomain contacts; other site 1075106004211 Cytokine receptor motif; other site 1075106004212 MoxR-like ATPases [General function prediction only]; Region: COG0714 1075106004213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106004214 Walker A motif; other site 1075106004215 ATP binding site [chemical binding]; other site 1075106004216 Walker B motif; other site 1075106004217 arginine finger; other site 1075106004218 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1075106004219 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1075106004220 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1075106004221 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1075106004222 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106004223 phosphopeptide binding site; other site 1075106004224 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1075106004225 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1075106004226 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1075106004227 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1075106004228 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1075106004229 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1075106004230 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1075106004231 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1075106004232 DNA binding site [nucleotide binding] 1075106004233 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1075106004234 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1075106004235 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1075106004236 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1075106004237 RPB1 interaction site [polypeptide binding]; other site 1075106004238 RPB10 interaction site [polypeptide binding]; other site 1075106004239 RPB11 interaction site [polypeptide binding]; other site 1075106004240 RPB3 interaction site [polypeptide binding]; other site 1075106004241 RPB12 interaction site [polypeptide binding]; other site 1075106004242 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1075106004243 endonuclease III; Region: ENDO3c; smart00478 1075106004244 minor groove reading motif; other site 1075106004245 helix-hairpin-helix signature motif; other site 1075106004246 substrate binding pocket [chemical binding]; other site 1075106004247 active site 1075106004248 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1075106004249 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1075106004250 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1075106004251 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1075106004252 active site 1075106004253 catalytic site [active] 1075106004254 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1075106004255 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1075106004256 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1075106004257 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1075106004258 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1075106004259 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1075106004260 dimer interface [polypeptide binding]; other site 1075106004261 active site 1075106004262 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1075106004263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1075106004264 DNA-binding site [nucleotide binding]; DNA binding site 1075106004265 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1075106004266 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1075106004267 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1075106004268 Ligand binding site; other site 1075106004269 Putative Catalytic site; other site 1075106004270 DXD motif; other site 1075106004271 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1075106004272 quinone interaction residues [chemical binding]; other site 1075106004273 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 1075106004274 active site 1075106004275 catalytic residues [active] 1075106004276 FMN binding site [chemical binding]; other site 1075106004277 substrate binding site [chemical binding]; other site 1075106004278 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1075106004279 active site 1075106004280 FMN binding site [chemical binding]; other site 1075106004281 substrate binding site [chemical binding]; other site 1075106004282 homotetramer interface [polypeptide binding]; other site 1075106004283 catalytic residue [active] 1075106004284 Transglycosylase; Region: Transgly; cl07896 1075106004285 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1075106004286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1075106004287 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1075106004288 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1075106004289 ligand binding site [chemical binding]; other site 1075106004290 flexible hinge region; other site 1075106004291 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1075106004292 putative switch regulator; other site 1075106004293 non-specific DNA interactions [nucleotide binding]; other site 1075106004294 DNA binding site [nucleotide binding] 1075106004295 sequence specific DNA binding site [nucleotide binding]; other site 1075106004296 putative cAMP binding site [chemical binding]; other site 1075106004297 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1075106004298 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1075106004299 TM2 domain; Region: TM2; cl00984 1075106004300 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1075106004301 tartrate dehydrogenase; Provisional; Region: PRK08194 1075106004302 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1075106004303 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106004304 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1075106004305 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1075106004306 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1075106004307 lipoyl attachment site [posttranslational modification]; other site 1075106004308 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1075106004309 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1075106004310 putative NADH binding site [chemical binding]; other site 1075106004311 putative active site [active] 1075106004312 nudix motif; other site 1075106004313 putative metal binding site [ion binding]; other site 1075106004314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1075106004315 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1075106004316 nudix motif; other site 1075106004317 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1075106004318 catalytic residues [active] 1075106004319 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1075106004320 G5 domain; Region: G5; pfam07501 1075106004321 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1075106004322 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1075106004323 catalytic residue [active] 1075106004324 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1075106004325 Bacterial sugar transferase; Region: Bac_transf; cl00939 1075106004326 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1075106004327 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1075106004328 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1075106004329 Ligand binding site; other site 1075106004330 Putative Catalytic site; other site 1075106004331 DXD motif; other site 1075106004332 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1075106004333 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1075106004334 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1075106004335 substrate binding site; other site 1075106004336 tetramer interface; other site 1075106004337 Cupin domain; Region: Cupin_2; cl09118 1075106004338 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1075106004339 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1075106004340 NADP binding site [chemical binding]; other site 1075106004341 active site 1075106004342 putative substrate binding site [chemical binding]; other site 1075106004343 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1075106004344 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1075106004345 NAD binding site [chemical binding]; other site 1075106004346 substrate binding site [chemical binding]; other site 1075106004347 homodimer interface [polypeptide binding]; other site 1075106004348 active site 1075106004349 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1075106004350 Probable Catalytic site; other site 1075106004351 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1075106004352 MatE; Region: MatE; cl10513 1075106004353 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1075106004354 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004355 active site 1075106004356 putative glycosyl transferase; Provisional; Region: PRK10073 1075106004357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1075106004358 active site 1075106004359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004360 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1075106004361 active site 1075106004362 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1075106004363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004364 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106004365 active site 1075106004366 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1075106004367 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1075106004368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004369 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1075106004370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004371 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1075106004372 MatE; Region: MatE; cl10513 1075106004373 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004374 active site 1075106004375 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1075106004376 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1075106004377 Bacterial sugar transferase; Region: Bac_transf; cl00939 1075106004378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106004379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004380 putative substrate translocation pore; other site 1075106004381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004382 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 1075106004383 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1075106004384 Protein of unknown function DUF262; Region: DUF262; cl14890 1075106004385 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1075106004386 active site 1075106004387 multimer interface [polypeptide binding]; other site 1075106004388 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1075106004389 predicted active site [active] 1075106004390 catalytic triad [active] 1075106004391 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1075106004392 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1075106004393 putative NAD(P) binding site [chemical binding]; other site 1075106004394 active site 1075106004395 putative substrate binding site [chemical binding]; other site 1075106004396 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 1075106004397 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1075106004398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004399 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1075106004400 active site 1075106004401 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1075106004402 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1075106004403 Ligand binding site; other site 1075106004404 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1075106004405 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1075106004406 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004407 Walker A/P-loop; other site 1075106004408 ATP binding site [chemical binding]; other site 1075106004409 Q-loop/lid; other site 1075106004410 ABC transporter signature motif; other site 1075106004411 Walker B; other site 1075106004412 D-loop; other site 1075106004413 H-loop/switch region; other site 1075106004414 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004416 Walker A/P-loop; other site 1075106004417 ATP binding site [chemical binding]; other site 1075106004418 Q-loop/lid; other site 1075106004419 ABC transporter signature motif; other site 1075106004420 Walker B; other site 1075106004421 D-loop; other site 1075106004422 H-loop/switch region; other site 1075106004423 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1075106004424 AMP-binding enzyme; Region: AMP-binding; cl15778 1075106004425 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1075106004426 putative active site [active] 1075106004427 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1075106004428 dimer interface [polypeptide binding]; other site 1075106004429 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1075106004430 nudix motif; other site 1075106004431 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1075106004432 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1075106004433 active site 1075106004434 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1075106004435 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1075106004436 Chain length determinant protein; Region: Wzz; cl15801 1075106004437 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1075106004438 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004439 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106004440 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106004441 CRISPR-associated helicase Cas3 family protein 1075106004442 homoserine kinase; Provisional; Region: PRK01212 1075106004443 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1075106004444 homoserine dehydrogenase; Provisional; Region: PRK06349 1075106004445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004446 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1075106004447 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1075106004448 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1075106004449 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1075106004450 catalytic residue [active] 1075106004451 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1075106004452 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1075106004453 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1075106004454 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 1075106004455 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1075106004456 active site 1075106004457 HIGH motif; other site 1075106004458 KMSK motif region; other site 1075106004459 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1075106004460 tRNA binding surface [nucleotide binding]; other site 1075106004461 anticodon binding site; other site 1075106004462 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1075106004463 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1075106004464 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1075106004465 homotrimer interaction site [polypeptide binding]; other site 1075106004466 putative active site [active] 1075106004467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004468 dimer interface [polypeptide binding]; other site 1075106004469 conserved gate region; other site 1075106004470 putative PBP binding loops; other site 1075106004471 ABC-ATPase subunit interface; other site 1075106004472 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1075106004473 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1075106004474 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1075106004475 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1075106004476 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1075106004477 Protein of unknown function DUF91; Region: DUF91; cl00709 1075106004478 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1075106004479 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1075106004480 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1075106004481 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1075106004482 alpha subunit interaction interface [polypeptide binding]; other site 1075106004483 Walker A motif; other site 1075106004484 ATP binding site [chemical binding]; other site 1075106004485 Walker B motif; other site 1075106004486 inhibitor binding site; inhibition site 1075106004487 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1075106004488 ATP synthase; Region: ATP-synt; cl00365 1075106004489 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1075106004490 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1075106004491 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1075106004492 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1075106004493 beta subunit interaction interface [polypeptide binding]; other site 1075106004494 Walker A motif; other site 1075106004495 ATP binding site [chemical binding]; other site 1075106004496 Walker B motif; other site 1075106004497 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1075106004498 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1075106004499 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1075106004500 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1075106004501 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1075106004502 ATP synthase A chain; Region: ATP-synt_A; cl00413 1075106004503 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1075106004504 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1075106004505 proposed active site lysine [active] 1075106004506 conserved cys residue [active] 1075106004507 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1075106004508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004509 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1075106004510 active site 1075106004511 tetramer interface [polypeptide binding]; other site 1075106004512 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1075106004513 Plasmid replication protein; Region: Rep_2; pfam01719 1075106004514 Protein of unknown function DUF262; Region: DUF262; cl14890 1075106004515 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1075106004516 active site 1075106004517 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 1075106004518 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1075106004519 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1075106004520 Int/Topo IB signature motif; other site 1075106004521 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1075106004522 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1075106004523 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 1075106004524 Cellulose or protein binding domain; Region: CBM_10; pfam02013 1075106004525 Membrane transport protein; Region: Mem_trans; cl09117 1075106004526 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1075106004527 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1075106004528 PYR/PP interface [polypeptide binding]; other site 1075106004529 dimer interface [polypeptide binding]; other site 1075106004530 TPP binding site [chemical binding]; other site 1075106004531 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1075106004532 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1075106004533 TPP-binding site; other site 1075106004534 dimer interface [polypeptide binding]; other site 1075106004535 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1075106004536 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 1075106004537 Cl- selectivity filter; other site 1075106004538 Cl- binding residues [ion binding]; other site 1075106004539 pore gating glutamate residue; other site 1075106004540 dimer interface [polypeptide binding]; other site 1075106004541 TQXA domain; Region: TQXA_dom; TIGR03934 1075106004542 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1075106004543 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1075106004544 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1075106004545 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1075106004546 active site 1075106004547 catalytic site [active] 1075106004548 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1075106004549 dimer interface [polypeptide binding]; other site 1075106004550 substrate binding site [chemical binding]; other site 1075106004551 metal binding sites [ion binding]; metal-binding site 1075106004552 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 1075106004553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1075106004554 DNA binding site [nucleotide binding] 1075106004555 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1075106004556 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1075106004557 minor groove reading motif; other site 1075106004558 helix-hairpin-helix signature motif; other site 1075106004559 substrate binding pocket [chemical binding]; other site 1075106004560 active site 1075106004561 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1075106004562 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1075106004563 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1075106004564 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1075106004565 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106004566 active site 1075106004567 HIGH motif; other site 1075106004568 nucleotide binding site [chemical binding]; other site 1075106004569 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106004570 active site 1075106004571 KMSKS motif; other site 1075106004572 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1075106004573 tRNA binding surface [nucleotide binding]; other site 1075106004574 anticodon binding site; other site 1075106004575 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1075106004576 Helix-turn-helix domains; Region: HTH; cl00088 1075106004577 Chorismate mutase type II; Region: CM_2; cl00693 1075106004578 transcription termination factor Rho; Provisional; Region: PRK12678 1075106004579 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1075106004580 transcription termination factor Rho; Provisional; Region: PRK12608 1075106004581 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1075106004582 RNA binding site [nucleotide binding]; other site 1075106004583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004584 Walker A motif; other site 1075106004585 ATP binding site [chemical binding]; other site 1075106004586 Walker B motif; other site 1075106004587 hypothetical protein; Provisional; Region: PRK07208 1075106004588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004590 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1075106004591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1075106004592 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1075106004593 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1075106004594 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1075106004595 GatB domain; Region: GatB_Yqey; cl11497 1075106004596 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1075106004597 Amidase; Region: Amidase; cl11426 1075106004598 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1075106004599 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1075106004600 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1075106004601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004602 ABC transporter signature motif; other site 1075106004603 Walker B; other site 1075106004604 D-loop; other site 1075106004605 H-loop/switch region; other site 1075106004606 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1075106004607 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1075106004608 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1075106004609 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106004610 copper exporting ATPase; Provisional; Region: copA; PRK10671 1075106004611 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1075106004612 Clp amino terminal domain; Region: Clp_N; pfam02861 1075106004613 Clp amino terminal domain; Region: Clp_N; pfam02861 1075106004614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106004615 Walker A motif; other site 1075106004616 ATP binding site [chemical binding]; other site 1075106004617 Walker B motif; other site 1075106004618 arginine finger; other site 1075106004619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106004620 Walker A motif; other site 1075106004621 ATP binding site [chemical binding]; other site 1075106004622 Walker B motif; other site 1075106004623 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1075106004624 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1075106004625 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1075106004626 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1075106004627 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1075106004628 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1075106004629 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1075106004630 active site 1075106004631 catalytic site [active] 1075106004632 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1075106004633 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1075106004634 catalytic residue [active] 1075106004635 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106004636 active site 1075106004637 HIGH motif; other site 1075106004638 nucleotide binding site [chemical binding]; other site 1075106004639 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106004640 active site 1075106004641 KMSKS motif; other site 1075106004642 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1075106004643 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1075106004644 amphipathic channel; other site 1075106004645 Asn-Pro-Ala signature motifs; other site 1075106004646 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1075106004647 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1075106004648 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1075106004649 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 1075106004650 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1075106004651 dimer interface [polypeptide binding]; other site 1075106004652 ssDNA binding site [nucleotide binding]; other site 1075106004653 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106004654 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1075106004655 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1075106004656 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1075106004657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106004658 active site 1075106004659 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1075106004660 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1075106004661 substrate binding site [chemical binding]; other site 1075106004662 dimer interface [polypeptide binding]; other site 1075106004663 ATP binding site [chemical binding]; other site 1075106004664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106004666 putative substrate translocation pore; other site 1075106004667 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1075106004668 active site 1075106004669 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004670 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004671 DNA binding site [nucleotide binding] 1075106004672 domain linker motif; other site 1075106004673 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106004674 dimerization interface [polypeptide binding]; other site 1075106004675 ligand binding site [chemical binding]; other site 1075106004676 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1075106004677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004678 UDP-galactopyranose mutase; Region: GLF; pfam03275 1075106004679 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106004680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004681 active site 1075106004682 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1075106004683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004684 active site 1075106004685 Sulfatase; Region: Sulfatase; cl10460 1075106004686 Sulfatase; Region: Sulfatase; cl10460 1075106004687 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106004688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004689 active site 1075106004690 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1075106004691 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1075106004692 active site 1075106004693 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1075106004694 active site 1075106004695 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1075106004696 S-layer homology domain; Region: SLH; pfam00395 1075106004697 S-layer homology domain; Region: SLH; pfam00395 1075106004698 S-layer homology domain; Region: SLH; pfam00395 1075106004699 MULE transposase domain; Region: MULE; pfam10551 1075106004700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1075106004701 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1075106004702 Substrate binding site [chemical binding]; other site 1075106004703 Leucine rich repeat; Region: LRR_8; pfam13855 1075106004704 S-layer homology domain; Region: SLH; pfam00395 1075106004705 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1075106004706 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1075106004707 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1075106004708 Walker A/P-loop; other site 1075106004709 ATP binding site [chemical binding]; other site 1075106004710 Q-loop/lid; other site 1075106004711 ABC transporter signature motif; other site 1075106004712 Walker B; other site 1075106004713 D-loop; other site 1075106004714 H-loop/switch region; other site 1075106004715 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1075106004716 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004717 active site 1075106004718 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106004719 FtsX-like permease family; Region: FtsX; cl15850 1075106004720 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106004721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004722 Walker A/P-loop; other site 1075106004723 ATP binding site [chemical binding]; other site 1075106004724 Q-loop/lid; other site 1075106004725 ABC transporter signature motif; other site 1075106004726 Walker B; other site 1075106004727 D-loop; other site 1075106004728 H-loop/switch region; other site 1075106004729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1075106004730 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1075106004731 putative active site [active] 1075106004732 putative dimer interface [polypeptide binding]; other site 1075106004733 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 1075106004734 K+ potassium transporter; Region: K_trans; cl15781 1075106004735 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1075106004736 active site 1075106004737 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1075106004738 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004739 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1075106004740 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1075106004741 Walker A/P-loop; other site 1075106004742 ATP binding site [chemical binding]; other site 1075106004743 Q-loop/lid; other site 1075106004744 ABC transporter signature motif; other site 1075106004745 Walker B; other site 1075106004746 D-loop; other site 1075106004747 H-loop/switch region; other site 1075106004748 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004749 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1075106004750 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1075106004751 Walker A/P-loop; other site 1075106004752 ATP binding site [chemical binding]; other site 1075106004753 Q-loop/lid; other site 1075106004754 ABC transporter signature motif; other site 1075106004755 Walker B; other site 1075106004756 D-loop; other site 1075106004757 H-loop/switch region; other site 1075106004758 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1075106004759 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1075106004760 active site 1075106004761 HIGH motif; other site 1075106004762 KMSKS motif; other site 1075106004763 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1075106004764 tRNA binding surface [nucleotide binding]; other site 1075106004765 anticodon binding site; other site 1075106004766 Predicted methyltransferases [General function prediction only]; Region: COG0313 1075106004767 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1075106004768 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1075106004769 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1075106004770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1075106004771 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106004772 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1075106004773 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1075106004774 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1075106004775 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1075106004776 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1075106004777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106004778 Helix-turn-helix domains; Region: HTH; cl00088 1075106004779 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1075106004780 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1075106004781 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1075106004782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106004783 motif II; other site 1075106004784 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1075106004785 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1075106004786 DNA binding residues [nucleotide binding] 1075106004787 putative dimer interface [polypeptide binding]; other site 1075106004788 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1075106004789 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1075106004790 HSP70 interaction site [polypeptide binding]; other site 1075106004791 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1075106004792 substrate binding site [polypeptide binding]; other site 1075106004793 dimer interface [polypeptide binding]; other site 1075106004794 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1075106004795 dimer interface [polypeptide binding]; other site 1075106004796 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1075106004797 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1075106004798 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004799 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004800 DNA binding site [nucleotide binding] 1075106004801 domain linker motif; other site 1075106004802 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106004803 ligand binding site [chemical binding]; other site 1075106004804 dimerization interface [polypeptide binding]; other site 1075106004805 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1075106004806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106004807 motif II; other site 1075106004808 pullulanase, type I; Region: pulA_typeI; TIGR02104 1075106004809 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1075106004810 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1075106004811 Ca binding site [ion binding]; other site 1075106004812 active site 1075106004813 catalytic site [active] 1075106004814 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 1075106004815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004816 dimer interface [polypeptide binding]; other site 1075106004817 conserved gate region; other site 1075106004818 putative PBP binding loops; other site 1075106004819 ABC-ATPase subunit interface; other site 1075106004820 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1075106004821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004822 dimer interface [polypeptide binding]; other site 1075106004823 conserved gate region; other site 1075106004824 putative PBP binding loops; other site 1075106004825 ABC-ATPase subunit interface; other site 1075106004826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1075106004827 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1075106004828 trehalose synthase; Region: treS_nterm; TIGR02456 1075106004829 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1075106004830 active site 1075106004831 catalytic site [active] 1075106004832 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1075106004833 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1075106004834 Protein of unknown function, DUF624; Region: DUF624; cl02369 1075106004835 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106004836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004837 dimer interface [polypeptide binding]; other site 1075106004838 conserved gate region; other site 1075106004839 putative PBP binding loops; other site 1075106004840 ABC-ATPase subunit interface; other site 1075106004841 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 1075106004842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1075106004843 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004844 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004845 DNA binding site [nucleotide binding] 1075106004846 domain linker motif; other site 1075106004847 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106004848 ligand binding site [chemical binding]; other site 1075106004849 dimerization interface [polypeptide binding]; other site 1075106004850 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1075106004851 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1075106004852 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1075106004853 active site 1075106004854 catalytic site [active] 1075106004855 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1075106004856 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106004857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106004858 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1075106004859 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1075106004860 dimer interface [polypeptide binding]; other site 1075106004861 FMN binding site [chemical binding]; other site 1075106004862 NADPH bind site [chemical binding]; other site 1075106004863 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1075106004864 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1075106004865 active site 1075106004866 catalytic triad [active] 1075106004867 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1075106004868 NAD synthetase; Reviewed; Region: nadE; PRK02628 1075106004869 RelB antitoxin; Region: RelB; cl01171 1075106004870 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1075106004871 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1075106004872 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1075106004873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1075106004874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004876 DNA binding site [nucleotide binding] 1075106004877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106004878 dimerization interface [polypeptide binding]; other site 1075106004879 ligand binding site [chemical binding]; other site 1075106004880 NAD-dependent deacetylase; Provisional; Region: PRK00481 1075106004881 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1075106004882 threonine dehydratase; Provisional; Region: PRK08198 1075106004883 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1075106004884 tetramer interface [polypeptide binding]; other site 1075106004885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106004886 catalytic residue [active] 1075106004887 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1075106004888 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1075106004889 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1075106004890 Ca binding site [ion binding]; other site 1075106004891 active site 1075106004892 catalytic site [active] 1075106004893 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1075106004894 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; cl14104 1075106004895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106004896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004897 dimer interface [polypeptide binding]; other site 1075106004898 conserved gate region; other site 1075106004899 putative PBP binding loops; other site 1075106004900 ABC-ATPase subunit interface; other site 1075106004901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004902 dimer interface [polypeptide binding]; other site 1075106004903 conserved gate region; other site 1075106004904 putative PBP binding loops; other site 1075106004905 ABC-ATPase subunit interface; other site 1075106004906 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1075106004907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1075106004908 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106004909 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1075106004910 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1075106004911 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1075106004912 catalytic site [active] 1075106004913 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1075106004914 nucleoside/Zn binding site; other site 1075106004915 dimer interface [polypeptide binding]; other site 1075106004916 catalytic motif [active] 1075106004917 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1075106004918 Predicted esterase [General function prediction only]; Region: COG0400 1075106004919 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1075106004920 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1075106004921 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1075106004922 trimer interface [polypeptide binding]; other site 1075106004923 active site 1075106004924 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1075106004925 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1075106004926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106004927 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1075106004928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106004929 motif II; other site 1075106004930 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1075106004931 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1075106004932 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1075106004933 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1075106004934 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106004935 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1075106004936 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1075106004937 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1075106004938 Walker A/P-loop; other site 1075106004939 ATP binding site [chemical binding]; other site 1075106004940 Q-loop/lid; other site 1075106004941 ABC transporter signature motif; other site 1075106004942 Walker B; other site 1075106004943 D-loop; other site 1075106004944 H-loop/switch region; other site 1075106004945 TOBE domain; Region: TOBE_2; cl01440 1075106004946 Ion channel; Region: Ion_trans_2; cl11596 1075106004947 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106004948 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1075106004949 active site 1075106004950 ATP binding site [chemical binding]; other site 1075106004951 substrate binding site [chemical binding]; other site 1075106004952 activation loop (A-loop); other site 1075106004953 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1075106004954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1075106004955 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1075106004956 G5 domain; Region: G5; pfam07501 1075106004957 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1075106004958 catalytic residue [active] 1075106004959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106004960 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1075106004961 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1075106004962 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1075106004963 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1075106004964 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1075106004965 active site 1075106004966 NTP binding site [chemical binding]; other site 1075106004967 metal binding triad [ion binding]; metal-binding site 1075106004968 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1075106004969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1075106004970 Zn2+ binding site [ion binding]; other site 1075106004971 Mg2+ binding site [ion binding]; other site 1075106004972 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1075106004973 active site 1075106004974 Ap6A binding site [chemical binding]; other site 1075106004975 nudix motif; other site 1075106004976 metal binding site [ion binding]; metal-binding site 1075106004977 integral membrane protein MviN; Region: mviN; TIGR01695 1075106004978 MatE; Region: MatE; cl10513 1075106004979 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1075106004980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106004981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1075106004982 ParB-like partition proteins; Region: parB_part; TIGR00180 1075106004983 ParB-like nuclease domain; Region: ParBc; cl02129 1075106004984 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1075106004985 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1075106004986 P-loop; other site 1075106004987 Magnesium ion binding site [ion binding]; other site 1075106004988 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1075106004989 Magnesium ion binding site [ion binding]; other site 1075106004990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1075106004991 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1075106004992 G-X-X-G motif; other site 1075106004993 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1075106004994 RxxxH motif; other site 1075106004995 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1075106004996 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1075106004997 IncFII RepA protein family; Region: IncFII_repA; cl11495 1075106004998 Ribosomal protein L34; Region: Ribosomal_L34; cl00370