-- dump date 20111121_010601 -- class Genbank::misc_feature -- table misc_feature_note -- id note 205913000001 Initiator Replication protein; Region: Rep_3; cl03080 205913000002 MobA/MobL family; Region: MobA_MobL; pfam03389 205913000003 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 205913000004 MobA/MobL family; Region: MobA_MobL; pfam03389 205913000005 Initiator Replication protein; Region: Rep_3; cl03080 205913000006 Replicase family; Region: Replicase; pfam03090 205913000007 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 205913000008 MobA/MobL family; Region: MobA_MobL; pfam03389 205913000009 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 205913000010 DNA-binding site [nucleotide binding]; DNA binding site 205913000011 RNA-binding motif; other site 205913000012 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 205913000013 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 205913000014 ring oligomerisation interface [polypeptide binding]; other site 205913000015 ATP/Mg binding site [chemical binding]; other site 205913000016 stacking interactions; other site 205913000017 hinge regions; other site 205913000018 Proteins of 100 residues with WXG; Region: WXG100; cl02005 205913000019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913000020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913000021 active site 205913000022 phosphorylation site [posttranslational modification] 205913000023 intermolecular recognition site; other site 205913000024 dimerization interface [polypeptide binding]; other site 205913000025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 205913000026 DNA binding site [nucleotide binding] 205913000027 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 205913000028 dimerization interface [polypeptide binding]; other site 205913000029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 205913000030 dimer interface [polypeptide binding]; other site 205913000031 phosphorylation site [posttranslational modification] 205913000032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913000033 ATP binding site [chemical binding]; other site 205913000034 Mg2+ binding site [ion binding]; other site 205913000035 G-X-G motif; other site 205913000036 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 205913000037 DNA-binding site [nucleotide binding]; DNA binding site 205913000038 RNA-binding motif; other site 205913000039 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 205913000040 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205913000041 Ligand Binding Site [chemical binding]; other site 205913000042 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205913000043 Ligand Binding Site [chemical binding]; other site 205913000044 Clp protease ATP binding subunit; Region: clpC; CHL00095 205913000045 Clp amino terminal domain; Region: Clp_N; pfam02861 205913000046 Clp amino terminal domain; Region: Clp_N; pfam02861 205913000047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913000048 Walker A motif; other site 205913000049 ATP binding site [chemical binding]; other site 205913000050 Walker B motif; other site 205913000051 arginine finger; other site 205913000052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913000053 Walker A motif; other site 205913000054 ATP binding site [chemical binding]; other site 205913000055 Walker B motif; other site 205913000056 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 205913000057 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 205913000058 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 205913000059 active site 205913000060 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 205913000061 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 205913000062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000063 metabolite-proton symporter; Region: 2A0106; TIGR00883 205913000064 putative substrate translocation pore; other site 205913000065 Creatinine amidohydrolase; Region: Creatininase; cl00618 205913000066 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913000067 active site 205913000068 metal binding site [ion binding]; metal-binding site 205913000069 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 205913000070 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 205913000071 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 205913000072 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 205913000073 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 205913000074 dimer interface [polypeptide binding]; other site 205913000075 motif 1; other site 205913000076 active site 205913000077 motif 2; other site 205913000078 motif 3; other site 205913000079 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 205913000080 anticodon binding site; other site 205913000081 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 205913000082 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 205913000083 dimer interface [polypeptide binding]; other site 205913000084 anticodon binding site; other site 205913000085 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913000086 motif 1; other site 205913000087 dimer interface [polypeptide binding]; other site 205913000088 active site 205913000089 motif 2; other site 205913000090 GAD domain; Region: GAD; pfam02938 205913000091 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913000092 active site 205913000093 motif 3; other site 205913000094 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205913000095 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 205913000096 Walker A/P-loop; other site 205913000097 ATP binding site [chemical binding]; other site 205913000098 Q-loop/lid; other site 205913000099 ABC transporter signature motif; other site 205913000100 Walker B; other site 205913000101 D-loop; other site 205913000102 H-loop/switch region; other site 205913000103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 205913000104 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205913000105 substrate binding pocket [chemical binding]; other site 205913000106 membrane-bound complex binding site; other site 205913000107 hinge residues; other site 205913000108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000109 dimer interface [polypeptide binding]; other site 205913000110 conserved gate region; other site 205913000111 ABC-ATPase subunit interface; other site 205913000112 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205913000113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000114 dimer interface [polypeptide binding]; other site 205913000115 conserved gate region; other site 205913000116 putative PBP binding loops; other site 205913000117 ABC-ATPase subunit interface; other site 205913000118 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role...; Region: PAP2_acid_phosphatase; cd03397 205913000119 active site 205913000120 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 205913000121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913000122 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913000123 Integrase core domain; Region: rve; cl01316 205913000124 putative transposase OrfB; Reviewed; Region: PHA02517 205913000125 Integrase core domain; Region: rve; cl01316 205913000126 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913000127 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913000128 DNA binding site [nucleotide binding] 205913000129 Int/Topo IB signature motif; other site 205913000130 active site 205913000131 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 205913000132 Phage integrase family; Region: Phage_integrase; pfam00589 205913000133 Int/Topo IB signature motif; other site 205913000134 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913000135 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913000136 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes...; Region: INT_pAE1; cd01188 205913000137 Int/Topo IB signature motif; other site 205913000138 putative transposase OrfB; Reviewed; Region: PHA02517 205913000139 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 205913000140 translation elongation factor aEF-2; Region: aEF-2; TIGR00490 205913000141 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines...; Region: Tet_like_IV; cd01684 205913000142 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-...; Region: Tet_C; cd03711 205913000143 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 205913000144 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 205913000145 G1 box; other site 205913000146 putative GEF interaction site [polypeptide binding]; other site 205913000147 GTP/Mg2+ binding site [chemical binding]; other site 205913000148 Switch I region; other site 205913000149 G2 box; other site 205913000150 G3 box; other site 205913000151 Switch II region; other site 205913000152 G4 box; other site 205913000153 G5 box; other site 205913000154 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 205913000155 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 205913000156 putative active site [active] 205913000157 putative metal binding site [ion binding]; other site 205913000158 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 205913000159 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 205913000160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 205913000161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913000162 nucleotide binding region [chemical binding]; other site 205913000163 ATP-binding site [chemical binding]; other site 205913000164 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 205913000165 recombination factor protein RarA; Reviewed; Region: PRK13342 205913000166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913000167 Walker A motif; other site 205913000168 ATP binding site [chemical binding]; other site 205913000169 Walker B motif; other site 205913000170 arginine finger; other site 205913000171 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 205913000172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913000173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913000174 active site 205913000175 phosphorylation site [posttranslational modification] 205913000176 intermolecular recognition site; other site 205913000177 dimerization interface [polypeptide binding]; other site 205913000178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 205913000179 DNA binding site [nucleotide binding] 205913000180 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205913000181 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 205913000182 dimerization interface [polypeptide binding]; other site 205913000183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 205913000184 dimer interface [polypeptide binding]; other site 205913000185 phosphorylation site [posttranslational modification] 205913000186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913000187 ATP binding site [chemical binding]; other site 205913000188 Mg2+ binding site [ion binding]; other site 205913000189 G-X-G motif; other site 205913000190 lipoprotein LpqB; Provisional; Region: PRK13614 205913000191 Sporulation and spore germination; Region: Germane; pfam10646 205913000192 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913000193 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205913000194 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 205913000195 Walker A/P-loop; other site 205913000196 ATP binding site [chemical binding]; other site 205913000197 Q-loop/lid; other site 205913000198 ABC transporter signature motif; other site 205913000199 Walker B; other site 205913000200 D-loop; other site 205913000201 H-loop/switch region; other site 205913000202 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 205913000203 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205913000204 TM-ABC transporter signature motif; other site 205913000205 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205913000206 TM-ABC transporter signature motif; other site 205913000207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000208 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205913000209 putative substrate translocation pore; other site 205913000210 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205913000211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913000212 Membrane protein of unknown function; Region: DUF360; cl00850 205913000213 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 205913000214 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 205913000215 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205913000216 Walker A/P-loop; other site 205913000217 ATP binding site [chemical binding]; other site 205913000218 Q-loop/lid; other site 205913000219 ABC transporter signature motif; other site 205913000220 Walker B; other site 205913000221 D-loop; other site 205913000222 H-loop/switch region; other site 205913000223 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 205913000224 Walker A/P-loop; other site 205913000225 ATP binding site [chemical binding]; other site 205913000226 Q-loop/lid; other site 205913000227 ABC transporter signature motif; other site 205913000228 Walker B; other site 205913000229 D-loop; other site 205913000230 H-loop/switch region; other site 205913000231 Cobalt transport protein; Region: CbiQ; cl00463 205913000232 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 205913000233 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 205913000234 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205913000235 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 205913000236 Probable Catalytic site [active] 205913000237 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913000238 Integrase core domain; Region: rve; cl01316 205913000239 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 205913000240 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913000241 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913000242 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205913000243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913000244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913000245 homodimer interface [polypeptide binding]; other site 205913000246 catalytic residue [active] 205913000247 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 205913000248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913000249 Walker A/P-loop; other site 205913000250 ATP binding site [chemical binding]; other site 205913000251 Q-loop/lid; other site 205913000252 ABC transporter signature motif; other site 205913000253 Walker B; other site 205913000254 D-loop; other site 205913000255 H-loop/switch region; other site 205913000256 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 205913000257 Ligase N family; Region: LIGANc; smart00532 205913000258 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 205913000259 nucleotide binding pocket [chemical binding]; other site 205913000260 K-X-D-G motif; other site 205913000261 catalytic site [active] 205913000262 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 205913000263 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 205913000264 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 205913000265 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 205913000266 Dimer interface [polypeptide binding]; other site 205913000267 Domain of unknown function DUF59; Region: DUF59; cl00941 205913000268 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 205913000269 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 205913000270 Walker A motif; other site 205913000271 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913000272 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913000273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000274 dimer interface [polypeptide binding]; other site 205913000275 conserved gate region; other site 205913000276 putative PBP binding loops; other site 205913000277 ABC-ATPase subunit interface; other site 205913000278 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 205913000279 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 205913000280 putative active site [active] 205913000281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913000282 putative alpha-glucosidase; Provisional; Region: PRK10658 205913000283 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 205913000284 active site 205913000285 catalytic site [active] 205913000286 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 205913000287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913000288 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 205913000289 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 205913000290 catalytic residues [active] 205913000291 trans-aconitate 2-methyltransferase; Provisional; Region: PRK01683 205913000292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 205913000293 S-adenosylmethionine binding site [chemical binding]; other site 205913000294 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 205913000295 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 205913000296 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913000297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913000298 Walker A/P-loop; other site 205913000299 ATP binding site [chemical binding]; other site 205913000300 Q-loop/lid; other site 205913000301 ABC transporter signature motif; other site 205913000302 Walker B; other site 205913000303 D-loop; other site 205913000304 H-loop/switch region; other site 205913000305 elongation factor P; Validated; Region: PRK00529 205913000306 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 205913000307 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 205913000308 RNA binding site [nucleotide binding]; other site 205913000309 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 205913000310 RNA binding site [nucleotide binding]; other site 205913000311 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 205913000312 putative RNA binding site [nucleotide binding]; other site 205913000313 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 205913000314 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 205913000315 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 205913000316 catalytic site [active] 205913000317 subunit interface [polypeptide binding]; other site 205913000318 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 205913000319 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205913000320 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 205913000321 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 205913000322 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205913000323 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 205913000324 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 205913000325 IMP binding site; other site 205913000326 dimer interface [polypeptide binding]; other site 205913000327 interdomain contacts; other site 205913000328 partial ornithine binding site; other site 205913000329 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 205913000330 active site 205913000331 dimer interface [polypeptide binding]; other site 205913000332 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 205913000333 catalytic site [active] 205913000334 G-X2-G-X-G-K; other site 205913000335 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 205913000336 active site 205913000337 substrate binding site [chemical binding]; other site 205913000338 catalytic site [active] 205913000339 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 205913000340 translation elongation factor EF-G; Region: EF-G; TIGR00484 205913000341 G1 box; other site 205913000342 putative GEF interaction site [polypeptide binding]; other site 205913000343 GTP/Mg2+ binding site [chemical binding]; other site 205913000344 Switch I region; other site 205913000345 G2 box; other site 205913000346 G3 box; other site 205913000347 Switch II region; other site 205913000348 G4 box; other site 205913000349 G5 box; other site 205913000350 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 205913000351 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 205913000352 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-...; Region: Tet_C; cd03711 205913000353 Predicted esterase [General function prediction only]; Region: COG0400 205913000354 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205913000355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000356 dimer interface [polypeptide binding]; other site 205913000357 conserved gate region; other site 205913000358 putative PBP binding loops; other site 205913000359 ABC-ATPase subunit interface; other site 205913000360 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205913000361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000362 dimer interface [polypeptide binding]; other site 205913000363 conserved gate region; other site 205913000364 putative PBP binding loops; other site 205913000365 ABC-ATPase subunit interface; other site 205913000366 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 205913000367 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205913000368 Walker A/P-loop; other site 205913000369 ATP binding site [chemical binding]; other site 205913000370 Q-loop/lid; other site 205913000371 ABC transporter signature motif; other site 205913000372 Walker B; other site 205913000373 D-loop; other site 205913000374 H-loop/switch region; other site 205913000375 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205913000376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 205913000377 substrate binding pocket [chemical binding]; other site 205913000378 membrane-bound complex binding site; other site 205913000379 hinge residues; other site 205913000380 hypothetical protein; Provisional; Region: PRK06460 205913000381 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 205913000382 homodimer interface [polypeptide binding]; other site 205913000383 substrate-cofactor binding pocket; other site 205913000384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913000385 catalytic residue [active] 205913000386 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 205913000387 catalytic residues [active] 205913000388 Rrf2 family protein; Region: rrf2_super; TIGR00738 205913000389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913000390 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 205913000391 NIL domain; Region: NIL; pfam09383 205913000392 methionine gamma-lyase; Provisional; Region: PRK07503 205913000393 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913000394 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 205913000395 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 205913000396 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 205913000397 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 205913000398 active site 205913000399 nucleophile elbow; other site 205913000400 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 205913000401 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 205913000402 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 205913000403 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 205913000404 Vitamin K epoxide reductase family; Region: VKOR; cl01729 205913000405 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 205913000406 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 205913000407 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 205913000408 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205913000409 substrate binding site [chemical binding]; other site 205913000410 UvrD/REP helicase; Region: UvrD-helicase; cl14126 205913000411 UvrD/REP helicase; Region: UvrD-helicase; cl14126 205913000412 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 205913000413 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 205913000414 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 205913000415 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 205913000416 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 205913000417 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 205913000418 DivIVA domain; Region: DivI1A_domain; TIGR03544 205913000419 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 205913000420 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 205913000421 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 205913000422 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 205913000423 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 205913000424 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 205913000425 Recombination protein O N terminal; Region: RecO_N; pfam11967 205913000426 Recombination protein O C terminal; Region: RecO_C; pfam02565 205913000427 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 205913000428 catalytic residue [active] 205913000429 putative FPP diphosphate binding site; other site 205913000430 putative FPP binding hydrophobic cleft; other site 205913000431 dimer interface [polypeptide binding]; other site 205913000432 putative IPP diphosphate binding site; other site 205913000433 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 205913000434 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 205913000435 active site 205913000436 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 205913000437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913000438 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 205913000439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 205913000440 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 205913000441 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 205913000442 substrate binding [chemical binding]; other site 205913000443 active site 205913000444 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 205913000445 galactoside permease; Reviewed; Region: lacY; PRK09528 205913000446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000447 putative substrate translocation pore; other site 205913000448 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913000449 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913000450 DNA binding site [nucleotide binding] 205913000451 domain linker motif; other site 205913000452 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 205913000453 putative dimerization interface [polypeptide binding]; other site 205913000454 putative ligand binding site [chemical binding]; other site 205913000455 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cd00172 205913000456 serpin-like protein; Provisional; Region: PHA02660 205913000457 reactive center loop; other site 205913000458 benzoate transport; Region: 2A0115; TIGR00895 205913000459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000460 putative substrate translocation pore; other site 205913000461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000462 putative substrate translocation pore; other site 205913000463 Domain of unknown function DUF77; Region: DUF77; cl00307 205913000464 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 205913000465 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 205913000466 substrate binding site [chemical binding]; other site 205913000467 dimer interface [polypeptide binding]; other site 205913000468 ATP binding site [chemical binding]; other site 205913000469 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 205913000470 thiamine phosphate binding site [chemical binding]; other site 205913000471 active site 205913000472 pyrophosphate binding site [ion binding]; other site 205913000473 ThiC family; Region: ThiC; cl08031 205913000474 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 205913000475 substrate binding site [chemical binding]; other site 205913000476 multimerization interface [polypeptide binding]; other site 205913000477 ATP binding site [chemical binding]; other site 205913000478 glycyl-tRNA synthetase; Provisional; Region: PRK04173 205913000479 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913000480 motif 1; other site 205913000481 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 205913000482 active site 205913000483 motif 2; other site 205913000484 motif 3; other site 205913000485 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 205913000486 anticodon binding site; other site 205913000487 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 205913000488 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 205913000489 FMN binding site [chemical binding]; other site 205913000490 active site 205913000491 catalytic residues [active] 205913000492 substrate binding site [chemical binding]; other site 205913000493 cell division protein FtsZ; Region: ftsZ; TIGR00065 205913000494 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 205913000495 nucleotide binding site [chemical binding]; other site 205913000496 SulA interaction site; other site 205913000497 Protein of unknown function (DUF552); Region: DUF552; cl00775 205913000498 YGGT family; Region: YGGT; cl00508 205913000499 DivIVA protein; Region: DivIVA; pfam05103 205913000500 DivIVA domain; Region: DivI1A_domain; TIGR03544 205913000501 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 205913000502 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 205913000503 active site 205913000504 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913000505 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 205913000506 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 205913000507 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 205913000508 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 205913000509 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 205913000510 generic binding surface II; other site 205913000511 generic binding surface I; other site 205913000512 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 205913000513 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 205913000514 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205913000515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205913000516 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 205913000517 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913000518 active site 205913000519 catalytic tetrad [active] 205913000520 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913000521 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 205913000522 Acylphosphatase; Region: Acylphosphatase; cl00551 205913000523 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 205913000524 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 205913000525 NAD binding site [chemical binding]; other site 205913000526 dimerization interface [polypeptide binding]; other site 205913000527 product binding site; other site 205913000528 substrate binding site [chemical binding]; other site 205913000529 zinc binding site [ion binding]; other site 205913000530 catalytic residues [active] 205913000531 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 205913000532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913000533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913000534 homodimer interface [polypeptide binding]; other site 205913000535 catalytic residue [active] 205913000536 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 205913000537 putative active site pocket [active] 205913000538 4-fold oligomerization interface [polypeptide binding]; other site 205913000539 metal binding residues [ion binding]; metal-binding site 205913000540 3-fold/trimer interface [polypeptide binding]; other site 205913000541 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 205913000542 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 205913000543 putative active site [active] 205913000544 oxyanion strand; other site 205913000545 catalytic triad [active] 205913000546 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 205913000547 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 205913000548 catalytic residues [active] 205913000549 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 205913000550 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205913000551 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205913000552 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205913000553 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205913000554 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 205913000555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913000556 ATP binding site [chemical binding]; other site 205913000557 putative Mg++ binding site [ion binding]; other site 205913000558 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 205913000559 Helicase associated domain (HA2); Region: HA2; cl04503 205913000560 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 205913000561 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 205913000562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 205913000563 S-adenosylmethionine binding site [chemical binding]; other site 205913000564 GTPases [General function prediction only]; Region: HflX; COG2262 205913000565 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 205913000566 G1 box; other site 205913000567 GTP/Mg2+ binding site [chemical binding]; other site 205913000568 Switch I region; other site 205913000569 G2 box; other site 205913000570 G3 box; other site 205913000571 Switch II region; other site 205913000572 G4 box; other site 205913000573 G5 box; other site 205913000574 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 205913000575 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 205913000576 NAD binding site [chemical binding]; other site 205913000577 dimer interface [polypeptide binding]; other site 205913000578 substrate binding site [chemical binding]; other site 205913000579 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913000580 Cation efflux family; Region: Cation_efflux; cl00316 205913000581 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 205913000582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913000583 LexA repressor; Validated; Region: PRK00215 205913000584 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 205913000585 Catalytic site [active] 205913000586 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 205913000587 putative peptidoglycan binding site; other site 205913000588 ATP cone domain; Region: ATP-cone; pfam03477 205913000589 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 205913000590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913000591 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 205913000592 L-serine binding site [chemical binding]; other site 205913000593 ACT domain interface; other site 205913000594 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 205913000595 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 205913000596 cell division protein MraZ; Reviewed; Region: PRK00326 205913000597 MraZ protein; Region: MraZ; pfam02381 205913000598 MraZ protein; Region: MraZ; pfam02381 205913000599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913000600 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 205913000601 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 205913000602 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 205913000603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 205913000604 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 205913000605 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 205913000606 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205913000607 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000608 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000609 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 205913000610 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 205913000611 Mg++ binding site [ion binding]; other site 205913000612 putative catalytic motif [active] 205913000613 putative substrate binding site [chemical binding]; other site 205913000614 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 205913000615 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000616 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 205913000617 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 205913000618 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 205913000619 active site 205913000620 homodimer interface [polypeptide binding]; other site 205913000621 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 205913000622 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205913000623 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000624 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000625 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 205913000626 Cell division protein FtsQ; Region: FtsQ; pfam03799 205913000627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 205913000628 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 205913000629 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 205913000630 putative active site [active] 205913000631 dimerization interface [polypeptide binding]; other site 205913000632 putative tRNAtyr binding site [nucleotide binding]; other site 205913000633 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 205913000634 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 205913000635 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 205913000636 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 205913000637 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 205913000638 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 205913000639 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 205913000640 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 205913000641 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 205913000642 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913000643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913000644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 205913000645 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 205913000646 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913000647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000648 putative PBP binding loops; other site 205913000649 dimer interface [polypeptide binding]; other site 205913000650 ABC-ATPase subunit interface; other site 205913000651 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 205913000652 putative active site [active] 205913000653 putative catalytic site [active] 205913000654 putative alpha-glucosidase; Provisional; Region: PRK10658 205913000655 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the...; Region: GH85_ENGase; cd06547 205913000656 putative active site [active] 205913000657 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 205913000658 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 205913000659 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913000660 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913000661 DNA binding site [nucleotide binding] 205913000662 domain linker motif; other site 205913000663 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913000664 ligand binding site [chemical binding]; other site 205913000665 dimerization interface [polypeptide binding]; other site 205913000666 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 205913000667 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 205913000668 putative active cleft [active] 205913000669 Uncharacterized conserved protein [Function unknown]; Region: COG3538 205913000670 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 205913000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 205913000672 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 205913000673 active site 205913000674 metal binding site [ion binding]; metal-binding site 205913000675 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 205913000676 putative substrate binding site [chemical binding]; other site 205913000677 putative ATP binding site [chemical binding]; other site 205913000678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913000679 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913000680 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913000681 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913000682 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913000683 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 205913000684 active site 205913000685 trimer interface [polypeptide binding]; other site 205913000686 allosteric site; other site 205913000687 active site lid [active] 205913000688 hexamer (dimer of trimers) interface [polypeptide binding]; other site 205913000689 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 205913000690 active site 205913000691 dimer interface [polypeptide binding]; other site 205913000692 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 205913000693 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205913000694 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205913000695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000696 dimer interface [polypeptide binding]; other site 205913000697 conserved gate region; other site 205913000698 putative PBP binding loops; other site 205913000699 ABC-ATPase subunit interface; other site 205913000700 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 205913000701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000702 dimer interface [polypeptide binding]; other site 205913000703 conserved gate region; other site 205913000704 ABC-ATPase subunit interface; other site 205913000705 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205913000706 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205913000707 Walker A/P-loop; other site 205913000708 ATP binding site [chemical binding]; other site 205913000709 Q-loop/lid; other site 205913000710 ABC transporter signature motif; other site 205913000711 Walker B; other site 205913000712 D-loop; other site 205913000713 H-loop/switch region; other site 205913000714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913000715 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205913000716 Walker A/P-loop; other site 205913000717 ATP binding site [chemical binding]; other site 205913000718 Q-loop/lid; other site 205913000719 ABC transporter signature motif; other site 205913000720 Walker B; other site 205913000721 D-loop; other site 205913000722 H-loop/switch region; other site 205913000723 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913000724 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 205913000725 nudix motif; other site 205913000726 proline aminopeptidase P II; Provisional; Region: PRK10879 205913000727 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 205913000728 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 205913000729 active site 205913000730 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 205913000731 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000732 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000733 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205913000734 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 205913000735 Walker A/P-loop; other site 205913000736 ATP binding site [chemical binding]; other site 205913000737 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 205913000738 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 205913000739 ABC transporter signature motif; other site 205913000740 Walker B; other site 205913000741 D-loop; other site 205913000742 H-loop/switch region; other site 205913000743 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 205913000744 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 205913000745 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000746 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000747 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 205913000748 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205913000749 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 205913000750 DNA binding residues [nucleotide binding] 205913000751 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 205913000752 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 205913000753 active site 205913000754 catalytic residues [active] 205913000755 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 205913000756 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 205913000757 active site 205913000758 catalytic residues [active] 205913000759 LytB protein; Region: LYTB; cl00507 205913000760 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 205913000761 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 205913000762 putative deacylase active site [active] 205913000763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913000764 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 205913000765 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 205913000766 Thiamine pyrophosphokinase; Region: TPK; cd07995 205913000767 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 205913000768 active site 205913000769 dimerization interface [polypeptide binding]; other site 205913000770 thiamine binding site [chemical binding]; other site 205913000771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 205913000772 S-adenosylmethionine binding site [chemical binding]; other site 205913000773 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 205913000774 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 205913000775 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 205913000776 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 205913000777 23S rRNA binding site [nucleotide binding]; other site 205913000778 L21 binding site [polypeptide binding]; other site 205913000779 L13 binding site [polypeptide binding]; other site 205913000780 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 205913000781 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 205913000782 Int/Topo IB signature motif; other site 205913000783 active site 205913000784 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913000785 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205913000786 Walker A/P-loop; other site 205913000787 ATP binding site [chemical binding]; other site 205913000788 Q-loop/lid; other site 205913000789 ABC transporter signature motif; other site 205913000790 Walker B; other site 205913000791 D-loop; other site 205913000792 H-loop/switch region; other site 205913000793 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 205913000794 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205913000795 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 205913000796 P-loop; other site 205913000797 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 205913000798 Magnesium ion binding site [ion binding]; other site 205913000799 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 205913000800 Magnesium ion binding site [ion binding]; other site 205913000801 ScpA/B protein; Region: ScpA_ScpB; cl00598 205913000802 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 205913000803 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 205913000804 nudix motif; other site 205913000805 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 205913000806 Quinolinate synthetase A protein; Region: NadA; cl00420 205913000807 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 205913000808 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913000809 domain; Region: Succ_DH_flav_C; pfam02910 205913000810 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 205913000811 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 205913000812 dimerization interface [polypeptide binding]; other site 205913000813 active site 205913000814 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913000815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913000816 catalytic residue [active] 205913000817 benzoate transport; Region: 2A0115; TIGR00895 205913000818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000819 putative substrate translocation pore; other site 205913000820 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 205913000821 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 205913000822 G1 box; other site 205913000823 putative GEF interaction site [polypeptide binding]; other site 205913000824 GTP/Mg2+ binding site [chemical binding]; other site 205913000825 Switch I region; other site 205913000826 G2 box; other site 205913000827 G3 box; other site 205913000828 Switch II region; other site 205913000829 G4 box; other site 205913000830 G5 box; other site 205913000831 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 205913000832 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 205913000833 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 205913000834 Prephenate dehydratase; Region: PDT; pfam00800 205913000835 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 205913000836 putative L-Phe binding site [chemical binding]; other site 205913000837 Prephenate dehydrogenase; Region: PDH; pfam02153 205913000838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913000839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913000840 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913000841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913000842 DNA binding site [nucleotide binding] 205913000843 Int/Topo IB signature motif; other site 205913000844 active site 205913000845 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 205913000846 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 205913000847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205913000848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000849 dimer interface [polypeptide binding]; other site 205913000850 conserved gate region; other site 205913000851 putative PBP binding loops; other site 205913000852 ABC-ATPase subunit interface; other site 205913000853 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913000854 Integrase core domain; Region: rve; cl01316 205913000855 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205913000856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913000857 dimer interface [polypeptide binding]; other site 205913000858 conserved gate region; other site 205913000859 putative PBP binding loops; other site 205913000860 ABC-ATPase subunit interface; other site 205913000861 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205913000862 Walker A/P-loop; other site 205913000863 ATP binding site [chemical binding]; other site 205913000864 Q-loop/lid; other site 205913000865 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205913000866 ABC transporter signature motif; other site 205913000867 Walker B; other site 205913000868 D-loop; other site 205913000869 H-loop/switch region; other site 205913000870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913000871 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205913000872 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 205913000873 Walker A/P-loop; other site 205913000874 ATP binding site [chemical binding]; other site 205913000875 Q-loop/lid; other site 205913000876 ABC transporter signature motif; other site 205913000877 Walker B; other site 205913000878 D-loop; other site 205913000879 H-loop/switch region; other site 205913000880 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913000881 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 205913000882 putative active site [active] 205913000883 putative DNA binding site [nucleotide binding]; other site 205913000884 putative phosphate binding site [ion binding]; other site 205913000885 putative catalytic site [active] 205913000886 metal binding site A [ion binding]; metal-binding site 205913000887 putative AP binding site [nucleotide binding]; other site 205913000888 putative metal binding site B [ion binding]; other site 205913000889 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 205913000890 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 205913000891 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 205913000892 TRAM domain; Region: TRAM; cl01282 205913000893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913000894 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913000895 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 205913000896 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913000897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913000898 aconitate hydratase; Validated; Region: PRK09277 205913000899 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 205913000900 substrate binding site [chemical binding]; other site 205913000901 ligand binding site [chemical binding]; other site 205913000902 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 205913000903 substrate binding site [chemical binding]; other site 205913000904 RelB antitoxin; Region: RelB; cl01171 205913000905 Protein of unknown function DUF262; Region: DUF262; cl14890 205913000906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205913000907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913000908 active site 205913000909 phosphorylation site [posttranslational modification] 205913000910 intermolecular recognition site; other site 205913000911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205913000912 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 205913000913 EamA-like transporter family; Region: EamA; cl01037 205913000914 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 205913000915 synthetase active site [active] 205913000916 NTP binding site [chemical binding]; other site 205913000917 metal binding site [ion binding]; metal-binding site 205913000918 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 205913000919 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 205913000920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 205913000921 FeS/SAM binding site; other site 205913000922 IPP transferase; Region: IPPT; cl00403 205913000923 Fic/DOC family; Region: Fic; cl00960 205913000924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913000925 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 205913000926 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 205913000927 Competence-damaged protein; Region: CinA; cl00666 205913000928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 205913000929 recombinase A; Provisional; Region: recA; PRK09354 205913000930 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 205913000931 hexamer interface [polypeptide binding]; other site 205913000932 Walker A motif; other site 205913000933 ATP binding site [chemical binding]; other site 205913000934 Walker B motif; other site 205913000935 RecX family; Region: RecX; cl00936 205913000936 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 205913000937 30S subunit binding site; other site 205913000938 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 205913000939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 205913000940 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 205913000941 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 205913000942 SEC-C motif; Region: SEC-C; cl12132 205913000943 Transposase; Region: DDE_Tnp_ISL3; pfam01610 205913000944 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 205913000945 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 205913000946 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 205913000947 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205913000948 putative acyl-acceptor binding pocket; other site 205913000949 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205913000950 active site 205913000951 ATP binding site [chemical binding]; other site 205913000952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913000953 substrate binding site [chemical binding]; other site 205913000954 activation loop (A-loop); other site 205913000955 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 205913000956 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 205913000957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 205913000958 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 205913000959 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 205913000960 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 205913000961 substrate binding pocket [chemical binding]; other site 205913000962 chain length determination region; other site 205913000963 substrate-Mg2+ binding site; other site 205913000964 catalytic residues [active] 205913000965 aspartate-rich region 1; other site 205913000966 active site lid residues [active] 205913000967 aspartate-rich region 2; other site 205913000968 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 205913000969 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 205913000970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205913000971 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205913000972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 205913000973 DNA binding residues [nucleotide binding] 205913000974 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 205913000975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 205913000976 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 205913000977 anchoring element; other site 205913000978 dimer interface [polypeptide binding]; other site 205913000979 ATP binding site [chemical binding]; other site 205913000980 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 205913000981 active site 205913000982 metal binding site [ion binding]; metal-binding site 205913000983 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205913000984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913000986 putative substrate translocation pore; other site 205913000987 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 205913000988 substrate binding site [chemical binding]; other site 205913000989 dimer interface [polypeptide binding]; other site 205913000990 ATP binding site [chemical binding]; other site 205913000991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 205913000992 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 205913000993 ATP binding site [chemical binding]; other site 205913000994 putative Mg++ binding site [ion binding]; other site 205913000995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913000996 nucleotide binding region [chemical binding]; other site 205913000997 ATP-binding site [chemical binding]; other site 205913000998 DEAD/H associated; Region: DEAD_assoc; pfam08494 205913000999 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 205913001000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913001001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 205913001002 phosphorylation site [posttranslational modification] 205913001003 intermolecular recognition site; other site 205913001004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 205913001005 DNA binding site [nucleotide binding] 205913001006 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 205913001007 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 205913001008 CAP-like domain; other site 205913001009 Active site [active] 205913001010 primary dimer interface [polypeptide binding]; other site 205913001011 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 205913001012 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913001013 Sulfatase; Region: Sulfatase; cl10460 205913001014 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 205913001015 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205913001016 trimer interface [polypeptide binding]; other site 205913001017 active site 205913001018 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 205913001019 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205913001020 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 205913001021 synthetase active site [active] 205913001022 NTP binding site [chemical binding]; other site 205913001023 metal binding site [ion binding]; metal-binding site 205913001024 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 205913001025 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 205913001026 putative transposase OrfB; Reviewed; Region: PHA02517 205913001027 Integrase core domain; Region: rve; cl01316 205913001028 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913001029 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913001030 DNA binding site [nucleotide binding] 205913001031 Int/Topo IB signature motif; other site 205913001032 active site 205913001033 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 205913001034 Phage integrase family; Region: Phage_integrase; pfam00589 205913001035 Int/Topo IB signature motif; other site 205913001036 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913001037 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913001038 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes...; Region: INT_pAE1; cd01188 205913001039 Int/Topo IB signature motif; other site 205913001040 Integrase core domain; Region: rve; cl01316 205913001041 Integrase core domain; Region: rve; cl01316 205913001042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913001043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913001044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205913001045 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 205913001046 active site 205913001047 EamA-like transporter family; Region: EamA; cl01037 205913001048 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205913001049 EamA-like transporter family; Region: EamA; cl01037 205913001050 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 205913001051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913001052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913001053 catalytic core [active] 205913001054 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 205913001055 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 205913001056 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205913001057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 205913001058 substrate binding pocket [chemical binding]; other site 205913001059 membrane-bound complex binding site; other site 205913001060 hinge residues; other site 205913001061 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 205913001062 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913001063 active site 205913001064 HIGH motif; other site 205913001065 nucleotide binding site [chemical binding]; other site 205913001066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913001067 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913001068 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913001069 active site 205913001070 KMSKS motif; other site 205913001071 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 205913001072 tRNA binding surface [nucleotide binding]; other site 205913001073 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 205913001074 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 205913001075 Competence protein; Region: Competence; cl00471 205913001076 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 205913001077 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 205913001078 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 205913001079 active site 205913001080 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 205913001081 hypothetical protein; Reviewed; Region: PRK07914 205913001082 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 205913001083 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 205913001084 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 205913001085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913001086 Coenzyme A binding pocket [chemical binding]; other site 205913001087 UGMP family protein; Validated; Region: PRK09604 205913001088 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 205913001089 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 205913001090 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913001091 DNA binding site [nucleotide binding] 205913001092 Int/Topo IB signature motif; other site 205913001093 active site 205913001094 Fic/DOC family; Region: Fic; cl00960 205913001095 Antirestriction protein (ArdA); Region: ArdA; cl01953 205913001096 NlpC/P60 family; Region: NLPC_P60; cl11438 205913001097 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 205913001098 catalytic residue [active] 205913001099 DNA topoisomerase III; Provisional; Region: PRK07726 205913001100 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 205913001101 active site 205913001102 putative interdomain interaction site [polypeptide binding]; other site 205913001103 putative metal-binding site [ion binding]; other site 205913001104 putative nucleotide binding site [chemical binding]; other site 205913001105 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 205913001106 domain I; other site 205913001107 DNA binding groove [nucleotide binding] 205913001108 phosphate binding site [ion binding]; other site 205913001109 domain II; other site 205913001110 domain III; other site 205913001111 nucleotide binding site [chemical binding]; other site 205913001112 catalytic site [active] 205913001113 domain IV; other site 205913001114 EcoRII C terminal; Region: EcoRII-C; pfam09019 205913001115 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 205913001116 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 205913001117 cofactor binding site; other site 205913001118 DNA binding site [nucleotide binding] 205913001119 substrate interaction site [chemical binding]; other site 205913001120 Fic/DOC family; Region: Fic; cl00960 205913001121 HipA N-terminal domain; Region: couple_hipA; TIGR03071 205913001122 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 205913001123 HipA-like N-terminal domain; Region: HipA_N; pfam07805 205913001124 HipA-like C-terminal domain; Region: HipA_C; pfam07804 205913001125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913001126 Walker A motif; other site 205913001127 ATP binding site [chemical binding]; other site 205913001128 Walker B motif; other site 205913001129 AAA-like domain; Region: AAA_10; pfam12846 205913001130 T surface-antigen of pili; Region: FctA; cl14038 205913001131 T surface-antigen of pili; Region: FctA; cl14038 205913001132 T surface-antigen of pili; Region: FctA; cl14038 205913001133 T surface-antigen of pili; Region: FctA; cl14038 205913001134 T surface-antigen of pili; Region: FctA; cl14038 205913001135 T surface-antigen of pili; Region: FctA; cl14038 205913001136 T surface-antigen of pili; Region: FctA; cl14038 205913001137 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205913001138 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 205913001139 P-loop; other site 205913001140 Magnesium ion binding site [ion binding]; other site 205913001141 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205913001142 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 205913001143 P-loop; other site 205913001144 Magnesium ion binding site [ion binding]; other site 205913001145 Transcription factor WhiB; Region: Whib; pfam02467 205913001146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913001147 non-specific DNA binding site [nucleotide binding]; other site 205913001148 salt bridge; other site 205913001149 sequence-specific DNA binding site [nucleotide binding]; other site 205913001150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913001151 non-specific DNA binding site [nucleotide binding]; other site 205913001152 salt bridge; other site 205913001153 sequence-specific DNA binding site [nucleotide binding]; other site 205913001154 Peptidase family M23; Region: Peptidase_M23; pfam01551 205913001155 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913001156 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913001157 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 205913001158 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 205913001159 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 205913001160 active site 205913001161 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 205913001162 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913001163 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913001164 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 205913001165 active site 205913001166 catalytic residues [active] 205913001167 metal binding site [ion binding]; metal-binding site 205913001168 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 205913001169 rRNA interaction site [nucleotide binding]; other site 205913001170 S8 interaction site; other site 205913001171 putative laminin-1 binding site; other site 205913001172 elongation factor Ts; Provisional; Region: tsf; PRK09377 205913001173 Elongation factor TS; Region: EF_TS; pfam00889 205913001174 Elongation factor TS; Region: EF_TS; pfam00889 205913001175 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 205913001176 putative nucleotide binding site [chemical binding]; other site 205913001177 uridine monophosphate binding site [chemical binding]; other site 205913001178 homohexameric interface [polypeptide binding]; other site 205913001179 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 205913001180 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 205913001181 hinge region; other site 205913001182 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 205913001183 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 205913001184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 205913001185 FeS/SAM binding site; other site 205913001186 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 205913001187 proposed catalytic triad [active] 205913001188 conserved cys residue [active] 205913001189 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 205913001190 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 205913001191 substrate binding site [chemical binding]; other site 205913001192 glutamase interaction surface [polypeptide binding]; other site 205913001193 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 205913001194 anthranilate synthase component I; Provisional; Region: PRK13571 205913001195 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 205913001196 chorismate binding enzyme; Region: Chorismate_bind; cl10555 205913001197 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 205913001198 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 205913001199 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913001200 Walker A/P-loop; other site 205913001201 ATP binding site [chemical binding]; other site 205913001202 Q-loop/lid; other site 205913001203 ABC transporter signature motif; other site 205913001204 Walker B; other site 205913001205 D-loop; other site 205913001206 H-loop/switch region; other site 205913001207 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 205913001208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 205913001209 classical (c) SDRs; Region: SDR_c; cd05233 205913001210 NAD(P) binding site [chemical binding]; other site 205913001211 active site 205913001212 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 205913001213 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 205913001214 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205913001215 Walker A/P-loop; other site 205913001216 ATP binding site [chemical binding]; other site 205913001217 Q-loop/lid; other site 205913001218 ABC transporter signature motif; other site 205913001219 Walker B; other site 205913001220 D-loop; other site 205913001221 H-loop/switch region; other site 205913001222 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 205913001223 Walker A/P-loop; other site 205913001224 ATP binding site [chemical binding]; other site 205913001225 Q-loop/lid; other site 205913001226 ABC transporter signature motif; other site 205913001227 Walker B; other site 205913001228 D-loop; other site 205913001229 H-loop/switch region; other site 205913001230 Cobalt transport protein; Region: CbiQ; cl00463 205913001231 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 205913001232 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 205913001233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 205913001234 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 205913001235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 205913001236 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 205913001237 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 205913001238 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 205913001239 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 205913001240 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 205913001241 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 205913001242 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 205913001243 UvrB/uvrC motif; Region: UVR; pfam02151 205913001244 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 205913001245 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 205913001246 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 205913001247 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 205913001248 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 205913001249 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 205913001250 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 205913001251 shikimate binding site; other site 205913001252 NAD(P) binding site [chemical binding]; other site 205913001253 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 205913001254 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 205913001255 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 205913001256 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 205913001257 substrate binding site [chemical binding]; other site 205913001258 hinge regions; other site 205913001259 ADP binding site [chemical binding]; other site 205913001260 catalytic site [active] 205913001261 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 205913001262 substrate binding site [chemical binding]; other site 205913001263 dimer interface [polypeptide binding]; other site 205913001264 catalytic triad [active] 205913001265 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 205913001266 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913001267 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 205913001268 NAD binding site [chemical binding]; other site 205913001269 dimer interface [polypeptide binding]; other site 205913001270 substrate binding site [chemical binding]; other site 205913001271 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 205913001272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913001273 active site 205913001274 motif I; other site 205913001275 motif II; other site 205913001276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913001277 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 205913001278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913001279 non-specific DNA binding site [nucleotide binding]; other site 205913001280 salt bridge; other site 205913001281 sequence-specific DNA binding site [nucleotide binding]; other site 205913001282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913001283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913001284 homodimer interface [polypeptide binding]; other site 205913001285 catalytic residue [active] 205913001286 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 205913001287 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 205913001288 putative active site [active] 205913001289 transaldolase; Provisional; Region: PRK03903 205913001290 catalytic residue [active] 205913001291 transketolase; Reviewed; Region: PRK05899 205913001292 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 205913001293 TPP-binding site [chemical binding]; other site 205913001294 dimer interface [polypeptide binding]; other site 205913001295 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205913001296 PYR/PP interface [polypeptide binding]; other site 205913001297 dimer interface [polypeptide binding]; other site 205913001298 TPP binding site [chemical binding]; other site 205913001299 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205913001300 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 205913001301 HrcA protein C terminal domain; Region: HrcA; pfam01628 205913001302 chaperone protein DnaJ; Provisional; Region: PRK14278 205913001303 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 205913001304 HSP70 interaction site [polypeptide binding]; other site 205913001305 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 205913001306 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 205913001307 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205913001308 Bacitracin resistance protein BacA; Region: BacA; cl00858 205913001309 PAC2 family; Region: PAC2; cl00847 205913001310 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 205913001311 thiS-thiF/thiG interaction site; other site 205913001312 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 205913001313 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 205913001314 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 205913001315 active site 205913001316 dimer interface [polypeptide binding]; other site 205913001317 motif 1; other site 205913001318 motif 2; other site 205913001319 motif 3; other site 205913001320 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 205913001321 anticodon binding site; other site 205913001322 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 205913001323 nucleotide binding site/active site [active] 205913001324 HIT family signature motif; other site 205913001325 catalytic residue [active] 205913001326 Domain of unknown function DUF28; Region: DUF28; cl00361 205913001327 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 205913001328 active site 205913001329 putative DNA-binding cleft [nucleotide binding]; other site 205913001330 dimer interface [polypeptide binding]; other site 205913001331 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 205913001332 RuvA N terminal domain; Region: RuvA_N; pfam01330 205913001333 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 205913001334 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 205913001335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913001336 Walker A motif; other site 205913001337 ATP binding site [chemical binding]; other site 205913001338 Walker B motif; other site 205913001339 arginine finger; other site 205913001340 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 205913001341 Preprotein translocase subunit; Region: YajC; cl00806 205913001342 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913001343 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 205913001344 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 205913001345 CoA-ligase; Region: Ligase_CoA; pfam00549 205913001346 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 205913001347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913001348 CoA-ligase; Region: Ligase_CoA; pfam00549 205913001349 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 205913001350 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 205913001351 purine monophosphate binding site [chemical binding]; other site 205913001352 dimer interface [polypeptide binding]; other site 205913001353 putative catalytic residues [active] 205913001354 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 205913001355 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 205913001356 amphipathic channel; other site 205913001357 Asn-Pro-Ala signature motifs; other site 205913001358 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 205913001359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205913001360 RNA binding surface [nucleotide binding]; other site 205913001361 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 205913001362 active site 205913001363 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 205913001364 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913001365 Active site [active] 205913001366 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 205913001367 CMP-binding site; other site 205913001368 The sites determining sugar specificity; other site 205913001369 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 205913001370 G1 box; other site 205913001371 GTP/Mg2+ binding site [chemical binding]; other site 205913001372 Switch I region; other site 205913001373 G2 box; other site 205913001374 Switch II region; other site 205913001375 G3 box; other site 205913001376 G4 box; other site 205913001377 G5 box; other site 205913001378 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 205913001379 G1 box; other site 205913001380 GTP/Mg2+ binding site [chemical binding]; other site 205913001381 Switch I region; other site 205913001382 G2 box; other site 205913001383 G3 box; other site 205913001384 Switch II region; other site 205913001385 G4 box; other site 205913001386 G5 box; other site 205913001387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205913001388 active site 205913001389 Predicted transcriptional regulator [Transcription]; Region: COG2378 205913001390 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 205913001391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913001392 ATP binding site [chemical binding]; other site 205913001393 putative Mg++ binding site [ion binding]; other site 205913001394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 205913001395 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 205913001396 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 205913001397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913001398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913001399 motif II; other site 205913001400 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 205913001401 DNA binding residues [nucleotide binding] 205913001402 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913001403 phosphopeptide binding site; other site 205913001404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 205913001405 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 205913001406 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 205913001407 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 205913001408 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 205913001409 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 205913001410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913001411 HisG, C-terminal domain; Region: HisG_C; cl06867 205913001412 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 205913001413 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 205913001414 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 205913001415 substrate binding site [chemical binding]; other site 205913001416 hexamer interface [polypeptide binding]; other site 205913001417 metal binding site [ion binding]; metal-binding site 205913001418 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 205913001419 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 205913001420 substrate binding site [chemical binding]; other site 205913001421 active site 205913001422 catalytic residues [active] 205913001423 heterodimer interface [polypeptide binding]; other site 205913001424 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 205913001425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913001426 endonuclease IV; Provisional; Region: PRK01060 205913001427 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 205913001428 AP (apurinic/apyrimidinic) site pocket; other site 205913001429 DNA interaction; other site 205913001430 Metal-binding active site; metal-binding site 205913001431 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 205913001432 Amino acid permease; Region: AA_permease; pfam00324 205913001433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913001434 putative substrate translocation pore; other site 205913001435 VanZ like family; Region: VanZ; cl01971 205913001436 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 205913001437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205913001438 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 205913001439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205913001440 Abi-like protein; Region: Abi_2; cl01988 205913001441 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 205913001442 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 205913001443 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 205913001444 nudix motif; other site 205913001445 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 205913001446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913001447 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 205913001448 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913001449 Integrase core domain; Region: rve; cl01316 205913001450 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 205913001451 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205913001452 Catalytic site [active] 205913001453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913001454 ABC transporter signature motif; other site 205913001455 Walker B; other site 205913001456 D-loop; other site 205913001457 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 205913001458 Fic/DOC family; Region: Fic; cl00960 205913001459 Protein of unknown function, DUF488; Region: DUF488; cl01246 205913001460 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 205913001461 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 205913001462 aspartate aminotransferase; Provisional; Region: PRK06836 205913001463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913001464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913001465 homodimer interface [polypeptide binding]; other site 205913001466 catalytic residue [active] 205913001467 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 205913001468 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 205913001469 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 205913001470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913001471 motif II; other site 205913001472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205913001473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913001474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205913001475 dimerization interface [polypeptide binding]; other site 205913001476 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 205913001477 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913001478 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 205913001479 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 205913001480 heterodimer interface [polypeptide binding]; other site 205913001481 active site 205913001482 FMN binding site [chemical binding]; other site 205913001483 homodimer interface [polypeptide binding]; other site 205913001484 substrate binding site [chemical binding]; other site 205913001485 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 205913001486 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 205913001487 FAD binding pocket [chemical binding]; other site 205913001488 FAD binding motif [chemical binding]; other site 205913001489 phosphate binding motif [ion binding]; other site 205913001490 beta-alpha-beta structure motif; other site 205913001491 NAD binding pocket [chemical binding]; other site 205913001492 Iron coordination center [ion binding]; other site 205913001493 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 205913001494 active site 205913001495 dimer interface [polypeptide binding]; other site 205913001496 dihydroorotase; Validated; Region: pyrC; PRK09357 205913001497 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 205913001498 active site 205913001499 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 205913001500 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 205913001501 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 205913001502 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 205913001503 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205913001504 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205913001505 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 205913001506 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205913001507 metal binding triad; other site 205913001508 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205913001509 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205913001510 metal binding triad; other site 205913001511 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205913001512 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 205913001513 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 205913001514 active site 205913001515 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 205913001516 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 205913001517 FAD binding site [chemical binding]; other site 205913001518 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 205913001519 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 205913001520 THF binding site; other site 205913001521 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 205913001522 substrate binding site [chemical binding]; other site 205913001523 THF binding site; other site 205913001524 zinc-binding site [ion binding]; other site 205913001525 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913001526 catalytic core [active] 205913001527 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 205913001528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 205913001529 S-adenosylmethionine binding site [chemical binding]; other site 205913001530 Predicted esterase [General function prediction only]; Region: COG0400 205913001531 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913001532 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913001533 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205913001534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 205913001535 active site 205913001536 catalytic tetrad [active] 205913001537 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 205913001538 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913001539 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913001540 Uncharacterized conserved protein [Function unknown]; Region: COG4715 205913001541 SWIM zinc finger; Region: SWIM; cl11618 205913001542 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 205913001543 Predicted permeases [General function prediction only]; Region: RarD; COG2962 205913001544 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 205913001545 Uncharacterized conserved protein [Function unknown]; Region: COG3410 205913001546 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 205913001547 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 205913001548 catalytic triad [active] 205913001549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913001550 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 205913001551 active site 205913001552 motif I; other site 205913001553 motif II; other site 205913001554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913001555 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913001556 Integrase core domain; Region: rve; cl01316 205913001557 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 205913001558 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 205913001559 Walker A/P-loop; other site 205913001560 ATP binding site [chemical binding]; other site 205913001561 Q-loop/lid; other site 205913001562 ABC transporter signature motif; other site 205913001563 Walker B; other site 205913001564 D-loop; other site 205913001565 H-loop/switch region; other site 205913001566 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 205913001567 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 205913001568 Protein of unknown function (DUF3111); Region: DUF3111; pfam11308 205913001569 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 205913001570 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205913001571 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 205913001572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913001573 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 205913001574 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 205913001575 active site 205913001576 dimer interface [polypeptide binding]; other site 205913001577 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 205913001578 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 205913001579 active site 205913001580 FMN binding site [chemical binding]; other site 205913001581 substrate binding site [chemical binding]; other site 205913001582 3Fe-4S cluster binding site [ion binding]; other site 205913001583 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 205913001584 domain interface; other site 205913001585 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913001586 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 205913001587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913001588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913001589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913001590 DNA binding site [nucleotide binding] 205913001591 domain linker motif; other site 205913001592 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 205913001593 ligand binding site [chemical binding]; other site 205913001594 dimerization interface (open form) [polypeptide binding]; other site 205913001595 dimerization interface (closed form) [polypeptide binding]; other site 205913001596 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 205913001597 MatE; Region: MatE; pfam01554 205913001598 MatE; Region: MatE; pfam01554 205913001599 Glycerate kinase family; Region: Gly_kinase; cl00841 205913001600 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913001601 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913001602 DNA binding site [nucleotide binding] 205913001603 domain linker motif; other site 205913001604 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913001605 dimerization interface [polypeptide binding]; other site 205913001606 ligand binding site [chemical binding]; other site 205913001607 Radical SAM; Region: Elp3; smart00729 205913001608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 205913001609 HemN C-terminal region; Region: HemN_C; pfam06969 205913001610 HemN C-terminal region; Region: HemN_C; pfam06969 205913001611 GTP-binding protein LepA; Provisional; Region: PRK05433 205913001612 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 205913001613 G1 box; other site 205913001614 putative GEF interaction site [polypeptide binding]; other site 205913001615 GTP/Mg2+ binding site [chemical binding]; other site 205913001616 Switch I region; other site 205913001617 G2 box; other site 205913001618 G3 box; other site 205913001619 Switch II region; other site 205913001620 G4 box; other site 205913001621 G5 box; other site 205913001622 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 205913001623 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 205913001624 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 205913001625 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 205913001626 UPF0126 domain; Region: UPF0126; pfam03458 205913001627 UPF0126 domain; Region: UPF0126; pfam03458 205913001628 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 205913001629 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 205913001630 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 205913001631 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 205913001632 homodimer interface [polypeptide binding]; other site 205913001633 substrate-cofactor binding pocket; other site 205913001634 catalytic residue [active] 205913001635 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 205913001636 5S rRNA interface [nucleotide binding]; other site 205913001637 CTC domain interface; other site 205913001638 L16 interface [polypeptide binding]; other site 205913001639 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205913001640 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 205913001641 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 205913001642 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 205913001643 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 205913001644 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 205913001645 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913001646 GTPase Era; Reviewed; Region: era; PRK00089 205913001647 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 205913001648 G1 box; other site 205913001649 GTP/Mg2+ binding site [chemical binding]; other site 205913001650 Switch I region; other site 205913001651 G2 box; other site 205913001652 Switch II region; other site 205913001653 G3 box; other site 205913001654 G4 box; other site 205913001655 G5 box; other site 205913001656 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 205913001657 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 205913001658 Domain of unknown function DUF21; Region: DUF21; pfam01595 205913001659 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205913001660 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 205913001661 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 205913001662 PhoH-like protein; Region: PhoH; cl12134 205913001663 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 205913001664 nucleotide binding site/active site [active] 205913001665 HIT family signature motif; other site 205913001666 catalytic residue [active] 205913001667 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 205913001668 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 205913001669 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205913001670 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 205913001671 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 205913001672 ligand binding site [chemical binding]; other site 205913001673 oligomer interface [polypeptide binding]; other site 205913001674 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 205913001675 dimer interface [polypeptide binding]; other site 205913001676 N-terminal domain interface [polypeptide binding]; other site 205913001677 sulfate 1 binding site; other site 205913001678 Domain of unknown function DUF59; Region: DUF59; cl00941 205913001679 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 205913001680 trimerization site [polypeptide binding]; other site 205913001681 active site 205913001682 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 205913001683 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 205913001684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913001685 catalytic residue [active] 205913001686 FeS assembly ATPase SufC; Region: sufC; TIGR01978 205913001687 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 205913001688 Walker A/P-loop; other site 205913001689 ATP binding site [chemical binding]; other site 205913001690 Q-loop/lid; other site 205913001691 ABC transporter signature motif; other site 205913001692 Walker B; other site 205913001693 D-loop; other site 205913001694 H-loop/switch region; other site 205913001695 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 205913001696 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 205913001697 FeS assembly protein SufB; Region: sufB; TIGR01980 205913001698 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 205913001699 CTP synthetase; Validated; Region: pyrG; PRK05380 205913001700 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 205913001701 Catalytic site [active] 205913001702 Active site [active] 205913001703 UTP binding site [chemical binding]; other site 205913001704 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 205913001705 active site 205913001706 putative oxyanion hole; other site 205913001707 catalytic triad [active] 205913001708 M28, and M42; Region: Zinc_peptidase_like; cl14876 205913001709 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 205913001710 metal binding site [ion binding]; metal-binding site 205913001711 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 205913001712 trimer interface [polypeptide binding]; other site 205913001713 active site 205913001714 dimer interface [polypeptide binding]; other site 205913001715 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 205913001716 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 205913001717 ADP binding site [chemical binding]; other site 205913001718 magnesium binding site [ion binding]; other site 205913001719 putative shikimate binding site; other site 205913001720 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 205913001721 active site 205913001722 dimer interface [polypeptide binding]; other site 205913001723 metal binding site [ion binding]; metal-binding site 205913001724 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 205913001725 Tetramer interface [polypeptide binding]; other site 205913001726 Active site [active] 205913001727 FMN-binding site [chemical binding]; other site 205913001728 YceG-like family; Region: YceG; pfam02618 205913001729 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 205913001730 dimerization interface [polypeptide binding]; other site 205913001731 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 205913001732 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 205913001733 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 205913001734 motif 1; other site 205913001735 active site 205913001736 motif 2; other site 205913001737 motif 3; other site 205913001738 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 205913001739 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 205913001740 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913001741 catalytic core [active] 205913001742 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205913001743 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 205913001744 catalytic triad [active] 205913001745 catalytic triad [active] 205913001746 oxyanion hole [active] 205913001747 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 205913001748 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 205913001749 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205913001750 RNA binding surface [nucleotide binding]; other site 205913001751 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 205913001752 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205913001753 Walker A/P-loop; other site 205913001754 ATP binding site [chemical binding]; other site 205913001755 Q-loop/lid; other site 205913001756 ABC transporter signature motif; other site 205913001757 Walker B; other site 205913001758 D-loop; other site 205913001759 H-loop/switch region; other site 205913001760 FtsX-like permease family; Region: FtsX; pfam02687 205913001761 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205913001762 UvrD/REP helicase; Region: UvrD-helicase; cl14126 205913001763 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 205913001764 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913001765 Permease family; Region: Xan_ur_permease; pfam00860 205913001766 Sulfate transporter family; Region: Sulfate_transp; cl00967 205913001767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 205913001768 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 205913001769 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205913001770 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913001771 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 205913001772 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 205913001773 Isochorismatase family; Region: Isochorismatase; pfam00857 205913001774 catalytic triad [active] 205913001775 metal binding site [ion binding]; metal-binding site 205913001776 conserved cis-peptide bond; other site 205913001777 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913001778 Divergent AAA domain; Region: AAA_4; pfam04326 205913001779 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 205913001780 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205913001781 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 205913001782 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 205913001783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913001784 Walker A/P-loop; other site 205913001785 ATP binding site [chemical binding]; other site 205913001786 Q-loop/lid; other site 205913001787 ABC transporter signature motif; other site 205913001788 Walker B; other site 205913001789 D-loop; other site 205913001790 H-loop/switch region; other site 205913001791 Histidine kinase; Region: HisKA_3; pfam07730 205913001792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 205913001793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913001794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913001795 active site 205913001796 phosphorylation site [posttranslational modification] 205913001797 intermolecular recognition site; other site 205913001798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 205913001799 DNA binding residues [nucleotide binding] 205913001800 dimerization interface [polypeptide binding]; other site 205913001801 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 205913001802 Phosphate transporter family; Region: PHO4; cl00396 205913001803 Protein of unknown function (DUF466); Region: DUF466; cl01082 205913001804 Carbon starvation protein CstA; Region: CstA; cl00856 205913001805 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913001806 maltodextrin glucosidase; Provisional; Region: PRK10785 205913001807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913001808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913001809 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 205913001810 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 205913001811 ATP binding site [chemical binding]; other site 205913001812 Mg++ binding site [ion binding]; other site 205913001813 motif III; other site 205913001814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913001815 nucleotide binding region [chemical binding]; other site 205913001816 ATP-binding site [chemical binding]; other site 205913001817 transcription termination factor Rho; Provisional; Region: PRK12678 205913001818 transcription termination factor Rho; Provisional; Region: PRK12678 205913001819 Sulfate transporter family; Region: Sulfate_transp; cl00967 205913001820 Permease family; Region: Xan_ur_permease; pfam00860 205913001821 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913001822 catalytic core [active] 205913001823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913001824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913001825 non-specific DNA binding site [nucleotide binding]; other site 205913001826 salt bridge; other site 205913001827 sequence-specific DNA binding site [nucleotide binding]; other site 205913001828 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 205913001829 Protein kinase domain; Region: Pkinase; pfam00069 205913001830 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205913001831 active site 205913001832 ATP binding site [chemical binding]; other site 205913001833 substrate binding site [chemical binding]; other site 205913001834 activation loop (A-loop); other site 205913001835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913001836 H+ Antiporter protein; Region: 2A0121; TIGR00900 205913001837 putative substrate translocation pore; other site 205913001838 putative transporter; Provisional; Region: PRK10504 205913001839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913001840 putative substrate translocation pore; other site 205913001841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913001842 FOG: CBS domain [General function prediction only]; Region: COG0517 205913001843 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_23; cd04636 205913001844 Domain of unknown function (DUF307); Region: DUF307; pfam03733 205913001845 Domain of unknown function (DUF307); Region: DUF307; pfam03733 205913001846 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913001847 active site 205913001848 metal binding site [ion binding]; metal-binding site 205913001849 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913001850 RNA ligase; Region: RNA_lig_T4_1; cl09743 205913001851 GTP-binding protein YchF; Reviewed; Region: PRK09601 205913001852 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 205913001853 G1 box; other site 205913001854 GTP/Mg2+ binding site [chemical binding]; other site 205913001855 Switch I region; other site 205913001856 G2 box; other site 205913001857 Switch II region; other site 205913001858 G3 box; other site 205913001859 G4 box; other site 205913001860 G5 box; other site 205913001861 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 205913001862 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 205913001863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913001864 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 205913001865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205913001866 Histidine kinase; Region: HisKA_3; pfam07730 205913001867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 205913001868 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913001869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913001870 active site 205913001871 phosphorylation site [posttranslational modification] 205913001872 intermolecular recognition site; other site 205913001873 dimerization interface [polypeptide binding]; other site 205913001874 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 205913001875 DNA binding residues [nucleotide binding] 205913001876 dimerization interface [polypeptide binding]; other site 205913001877 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 205913001878 FtsX-like permease family; Region: FtsX; pfam02687 205913001879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913001880 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205913001881 Walker A/P-loop; other site 205913001882 ATP binding site [chemical binding]; other site 205913001883 Q-loop/lid; other site 205913001884 ABC transporter signature motif; other site 205913001885 Walker B; other site 205913001886 D-loop; other site 205913001887 H-loop/switch region; other site 205913001888 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 205913001889 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 205913001890 homodimer interface [polypeptide binding]; other site 205913001891 substrate-cofactor binding pocket; other site 205913001892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913001893 catalytic residue [active] 205913001894 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 205913001895 dimer interface [polypeptide binding]; other site 205913001896 pyridoxal binding site [chemical binding]; other site 205913001897 ATP binding site [chemical binding]; other site 205913001898 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 205913001899 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 205913001900 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 205913001901 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913001902 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 205913001903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913001904 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 205913001905 domain; Region: Succ_DH_flav_C; pfam02910 205913001906 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 205913001907 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 205913001908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913001909 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 205913001910 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 205913001911 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 205913001912 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 205913001913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913001914 Walker A motif; other site 205913001915 ATP binding site [chemical binding]; other site 205913001916 Walker B motif; other site 205913001917 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 205913001918 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 205913001919 oligomer interface [polypeptide binding]; other site 205913001920 active site residues [active] 205913001921 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 205913001922 oligomer interface [polypeptide binding]; other site 205913001923 active site residues [active] 205913001924 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-...; Region: ClC_like; cd01033 205913001925 putative ion selectivity filter; other site 205913001926 putative pore gating glutamate residue; other site 205913001927 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 205913001928 dimer interface [polypeptide binding]; other site 205913001929 trigger factor; Provisional; Region: tig; PRK01490 205913001930 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205913001931 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 205913001932 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 205913001933 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 205913001934 active site 205913001935 catalytic site [active] 205913001936 substrate binding site [chemical binding]; other site 205913001937 HRDC domain; Region: HRDC; cl02578 205913001938 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 205913001939 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 205913001940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 205913001941 FeS/SAM binding site; other site 205913001942 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 205913001943 Pyruvate formate lyase 1; Region: PFL1; cd01678 205913001944 coenzyme A binding site [chemical binding]; other site 205913001945 active site 205913001946 catalytic residues [active] 205913001947 glycine loop; other site 205913001948 NAD synthetase; Provisional; Region: PRK13981 205913001949 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 205913001950 multimer interface [polypeptide binding]; other site 205913001951 active site 205913001952 catalytic triad [active] 205913001953 protein interface 1 [polypeptide binding]; other site 205913001954 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 205913001955 homodimer interface [polypeptide binding]; other site 205913001956 NAD binding pocket [chemical binding]; other site 205913001957 ATP binding pocket [chemical binding]; other site 205913001958 Mg binding site [ion binding]; other site 205913001959 active-site loop [active] 205913001960 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 205913001961 M28, and M42; Region: Zinc_peptidase_like; cl14876 205913001962 metal binding site [ion binding]; metal-binding site 205913001963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 205913001964 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 205913001965 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 205913001966 Walker A/P-loop; other site 205913001967 ATP binding site [chemical binding]; other site 205913001968 Q-loop/lid; other site 205913001969 ABC transporter signature motif; other site 205913001970 Walker B; other site 205913001971 D-loop; other site 205913001972 H-loop/switch region; other site 205913001973 NIL domain; Region: NIL; pfam09383 205913001974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913001975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913001976 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 205913001977 active site 205913001978 motif I; other site 205913001979 motif II; other site 205913001980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913001981 putative phosphoketolase; Provisional; Region: PRK05261 205913001982 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 205913001983 TPP-binding site [chemical binding]; other site 205913001984 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 205913001985 XFP C-terminal domain; Region: XFP_C; pfam09363 205913001986 GMP synthase; Reviewed; Region: guaA; PRK00074 205913001987 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 205913001988 AMP/PPi binding site [chemical binding]; other site 205913001989 candidate oxyanion hole; other site 205913001990 catalytic triad [active] 205913001991 potential glutamine specificity residues [chemical binding]; other site 205913001992 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 205913001993 ATP Binding subdomain [chemical binding]; other site 205913001994 Ligand Binding sites [chemical binding]; other site 205913001995 Dimerization subdomain; other site 205913001996 Membrane transport protein; Region: Mem_trans; cl09117 205913001997 Low molecular weight phosphatase family; Region: LMWPc; cd00115 205913001998 Active site [active] 205913001999 Integrase core domain; Region: rve; cl01316 205913002000 Integrase core domain; Region: rve; cl01316 205913002001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913002002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913002003 Integrase core domain; Region: rve; cl01316 205913002004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002005 Protein of unknown function, DUF600; Region: DUF600; cl04640 205913002006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 205913002007 hypothetical protein; Provisional; Region: PRK13663 205913002008 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205913002009 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 205913002010 catalytic triad [active] 205913002011 catalytic triad [active] 205913002012 oxyanion hole [active] 205913002013 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913002014 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 205913002015 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 205913002016 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 205913002017 Substrate binding site [chemical binding]; other site 205913002018 Mg++ binding site [ion binding]; other site 205913002019 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 205913002020 active site 205913002021 substrate binding site [chemical binding]; other site 205913002022 CoA binding site [chemical binding]; other site 205913002023 Domain of unknown function DUF143; Region: DUF143; cl00519 205913002024 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913002025 catalytic core [active] 205913002026 phosphate acetyltransferase; Reviewed; Region: PRK05632 205913002027 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 205913002028 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 205913002029 Acetokinase family; Region: Acetate_kinase; cl01029 205913002030 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 205913002031 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 205913002032 hinge; other site 205913002033 active site 205913002034 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 205913002035 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 205913002036 putative transporter; Provisional; Region: PRK11462 205913002037 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 205913002038 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 205913002039 domain; Region: Glyco_hydro_2; pfam00703 205913002040 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 205913002041 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 205913002042 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 205913002043 Uncharacterized conserved protein [Function unknown]; Region: COG4832 205913002044 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 205913002045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913002046 non-specific DNA binding site [nucleotide binding]; other site 205913002047 salt bridge; other site 205913002048 sequence-specific DNA binding site [nucleotide binding]; other site 205913002049 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 205913002050 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 205913002051 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 205913002052 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 205913002053 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913002054 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 205913002055 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 205913002056 dimer interface [polypeptide binding]; other site 205913002057 ADP-ribose binding site [chemical binding]; other site 205913002058 active site 205913002059 nudix motif; other site 205913002060 metal binding site [ion binding]; metal-binding site 205913002061 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 205913002062 DNA polymerase I; Provisional; Region: PRK05755 205913002063 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 205913002064 active site 205913002065 metal binding site 1 [ion binding]; metal-binding site 205913002066 putative 5' ssDNA interaction site; other site 205913002067 metal binding site 3; metal-binding site 205913002068 metal binding site 2 [ion binding]; metal-binding site 205913002069 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 205913002070 putative DNA binding site [nucleotide binding]; other site 205913002071 putative metal binding site [ion binding]; other site 205913002072 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 205913002073 active site 205913002074 substrate binding site [chemical binding]; other site 205913002075 catalytic site [active] 205913002076 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 205913002077 active site 205913002078 DNA binding site [nucleotide binding] 205913002079 catalytic site [active] 205913002080 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 205913002081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913002082 active site 205913002083 phosphorylation site [posttranslational modification] 205913002084 intermolecular recognition site; other site 205913002085 dimerization interface [polypeptide binding]; other site 205913002086 ANTAR domain; Region: ANTAR; pfam03861 205913002087 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 205913002088 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 205913002089 dimer interface [polypeptide binding]; other site 205913002090 ADP-ribose binding site [chemical binding]; other site 205913002091 active site 205913002092 nudix motif; other site 205913002093 metal binding site [ion binding]; metal-binding site 205913002094 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205913002095 pyruvate kinase; Provisional; Region: PRK05826 205913002096 domain interfaces; other site 205913002097 active site 205913002098 Integral membrane protein TerC family; Region: TerC; cl10468 205913002099 excinuclease ABC subunit B; Provisional; Region: PRK05298 205913002100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 205913002101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913002102 nucleotide binding region [chemical binding]; other site 205913002103 ATP-binding site [chemical binding]; other site 205913002104 Ultra-violet resistance protein B; Region: UvrB; pfam12344 205913002105 UvrB/uvrC motif; Region: UVR; pfam02151 205913002106 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 205913002107 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 205913002108 CoA-binding site [chemical binding]; other site 205913002109 ATP-binding [chemical binding]; other site 205913002110 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 205913002111 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 205913002112 RNA binding site [nucleotide binding]; other site 205913002113 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 205913002114 RNA binding site [nucleotide binding]; other site 205913002115 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 205913002116 RNA binding site [nucleotide binding]; other site 205913002117 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 205913002118 RNA binding site [nucleotide binding]; other site 205913002119 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 205913002120 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 205913002121 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 205913002122 homodimer interface [polypeptide binding]; other site 205913002123 NADP binding site [chemical binding]; other site 205913002124 substrate binding site [chemical binding]; other site 205913002125 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 205913002126 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205913002127 metal binding site [ion binding]; metal-binding site 205913002128 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 205913002129 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 205913002130 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 205913002131 ABC-ATPase subunit interface; other site 205913002132 dimer interface [polypeptide binding]; other site 205913002133 putative PBP binding regions; other site 205913002134 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 205913002135 homotrimer interaction site [polypeptide binding]; other site 205913002136 zinc binding site [ion binding]; other site 205913002137 CDP-binding sites; other site 205913002138 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 205913002139 glycogen branching enzyme; Provisional; Region: PRK05402 205913002140 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 205913002141 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913002142 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 205913002143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913002144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913002145 active site 205913002146 phosphorylation site [posttranslational modification] 205913002147 intermolecular recognition site; other site 205913002148 dimerization interface [polypeptide binding]; other site 205913002149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 205913002150 DNA binding site [nucleotide binding] 205913002151 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205913002152 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 205913002153 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 205913002154 dimerization interface [polypeptide binding]; other site 205913002155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 205913002156 dimer interface [polypeptide binding]; other site 205913002157 phosphorylation site [posttranslational modification] 205913002158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913002159 ATP binding site [chemical binding]; other site 205913002160 Mg2+ binding site [ion binding]; other site 205913002161 G-X-G motif; other site 205913002162 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 205913002163 Catalytic site [active] 205913002164 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913002165 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 205913002166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913002167 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 205913002168 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 205913002169 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205913002170 Transcription factor WhiB; Region: Whib; pfam02467 205913002171 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 205913002172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913002173 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913002174 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913002175 Walker A/P-loop; other site 205913002176 ATP binding site [chemical binding]; other site 205913002177 Transcription factor WhiB; Region: Whib; pfam02467 205913002178 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 205913002179 PAS fold; Region: PAS_4; pfam08448 205913002180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 205913002181 Histidine kinase; Region: HisKA_2; cl06527 205913002182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 205913002183 Haemolysin-III related; Region: HlyIII; cl03831 205913002184 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 205913002185 domain; Region: GreA_GreB_N; pfam03449 205913002186 C-term; Region: GreA_GreB; pfam01272 205913002187 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205913002188 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 205913002189 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 205913002190 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 205913002191 exopolyphosphatase; Region: exo_poly_only; TIGR03706 205913002192 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 205913002193 Protein of unknown function (DUF501); Region: DUF501; cl00652 205913002194 Septum formation initiator; Region: DivIC; cl11433 205913002195 enolase; Provisional; Region: eno; PRK00077 205913002196 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 205913002197 dimer interface [polypeptide binding]; other site 205913002198 metal binding site [ion binding]; metal-binding site 205913002199 substrate binding pocket [chemical binding]; other site 205913002200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 205913002201 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913002202 active site 205913002203 catalytic tetrad [active] 205913002204 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 205913002205 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 205913002206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913002207 ATP binding site [chemical binding]; other site 205913002208 putative Mg++ binding site [ion binding]; other site 205913002209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913002210 nucleotide binding region [chemical binding]; other site 205913002211 ATP-binding site [chemical binding]; other site 205913002212 TRCF domain; Region: TRCF; pfam03461 205913002213 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 205913002214 putative active site [active] 205913002215 catalytic residue [active] 205913002216 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205913002217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913002218 Coenzyme A binding pocket [chemical binding]; other site 205913002219 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 205913002220 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 205913002221 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205913002222 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 205913002223 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 205913002224 active site 205913002225 (T/H)XGH motif; other site 205913002226 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 205913002227 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 205913002228 putative catalytic cysteine [active] 205913002229 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913002230 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913002231 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 205913002232 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 205913002233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002234 catalytic residue [active] 205913002235 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 205913002236 plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517 205913002237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913002238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913002239 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 205913002240 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 205913002241 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 205913002242 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 205913002243 Walker A/P-loop; other site 205913002244 ATP binding site [chemical binding]; other site 205913002245 Q-loop/lid; other site 205913002246 ABC transporter signature motif; other site 205913002247 Walker B; other site 205913002248 D-loop; other site 205913002249 H-loop/switch region; other site 205913002250 Predicted transcriptional regulators [Transcription]; Region: COG1725 205913002251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205913002252 DNA-binding site [nucleotide binding]; DNA binding site 205913002253 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 205913002254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913002255 motif II; other site 205913002256 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 205913002257 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 205913002258 Walker A/P-loop; other site 205913002259 ATP binding site [chemical binding]; other site 205913002260 Q-loop/lid; other site 205913002261 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 205913002262 ABC transporter signature motif; other site 205913002263 Walker B; other site 205913002264 D-loop; other site 205913002265 H-loop/switch region; other site 205913002266 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 205913002267 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 205913002268 Cation transport protein; Region: TrkH; cl10514 205913002269 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 205913002270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913002271 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 205913002272 Protein of unknown function (DUF342); Region: DUF342; pfam03961 205913002273 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 205913002274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205913002275 RNA binding surface [nucleotide binding]; other site 205913002276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913002277 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 205913002278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913002279 active site 205913002280 motif I; other site 205913002281 motif II; other site 205913002282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913002283 motif II; other site 205913002284 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 205913002285 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 205913002286 active site 205913002287 HIGH motif; other site 205913002288 dimer interface [polypeptide binding]; other site 205913002289 KMSKS motif; other site 205913002290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 205913002291 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 205913002292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205913002293 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 205913002294 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 205913002295 ATP binding site [chemical binding]; other site 205913002296 substrate interface [chemical binding]; other site 205913002297 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 205913002298 ThiS interaction site; other site 205913002299 putative active site [active] 205913002300 tetramer interface [polypeptide binding]; other site 205913002301 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 205913002302 thiS-thiF/thiG interaction site; other site 205913002303 argininosuccinate lyase; Provisional; Region: PRK00855 205913002304 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 205913002305 active sites [active] 205913002306 tetramer interface [polypeptide binding]; other site 205913002307 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 205913002308 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 205913002309 ANP binding site [chemical binding]; other site 205913002310 Substrate Binding Site II [chemical binding]; other site 205913002311 Substrate Binding Site I [chemical binding]; other site 205913002312 arginine repressor; Provisional; Region: PRK03341 205913002313 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 205913002314 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 205913002315 ornithine carbamoyltransferase; Provisional; Region: PRK00779 205913002316 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205913002317 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205913002318 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 205913002319 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 205913002320 inhibitor-cofactor binding pocket; inhibition site 205913002321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002322 catalytic residue [active] 205913002323 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 205913002324 feedback inhibition sensing region; other site 205913002325 homohexameric interface [polypeptide binding]; other site 205913002326 nucleotide binding site [chemical binding]; other site 205913002327 N-acetyl-L-glutamate binding site [chemical binding]; other site 205913002328 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 205913002329 heterotetramer interface [polypeptide binding]; other site 205913002330 active site pocket [active] 205913002331 cleavage site 205913002332 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 205913002333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913002334 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 205913002335 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 205913002336 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 205913002337 putative tRNA-binding site [nucleotide binding]; other site 205913002338 B3/4 domain; Region: B3_4; cl11458 205913002339 tRNA synthetase B5 domain; Region: B5; cl08394 205913002340 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 205913002341 dimer interface [polypeptide binding]; other site 205913002342 motif 1; other site 205913002343 motif 3; other site 205913002344 motif 2; other site 205913002345 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 205913002346 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 205913002347 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 205913002348 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 205913002349 dimer interface [polypeptide binding]; other site 205913002350 motif 1; other site 205913002351 active site 205913002352 motif 2; other site 205913002353 motif 3; other site 205913002354 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 205913002355 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 205913002356 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205913002357 Cobalt transport protein; Region: CbiQ; cl00463 205913002358 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 205913002359 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 205913002360 Walker A/P-loop; other site 205913002361 ATP binding site [chemical binding]; other site 205913002362 Q-loop/lid; other site 205913002363 ABC transporter signature motif; other site 205913002364 Walker B; other site 205913002365 D-loop; other site 205913002366 H-loop/switch region; other site 205913002367 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 205913002368 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 205913002369 Walker A/P-loop; other site 205913002370 ATP binding site [chemical binding]; other site 205913002371 Q-loop/lid; other site 205913002372 ABC transporter signature motif; other site 205913002373 Walker B; other site 205913002374 D-loop; other site 205913002375 H-loop/switch region; other site 205913002376 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 205913002377 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 205913002378 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 205913002379 active site 205913002380 metal binding site [ion binding]; metal-binding site 205913002381 dimer interface [polypeptide binding]; other site 205913002382 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 205913002383 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 205913002384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913002385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913002386 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205913002387 glutamine synthetase, type I; Region: GlnA; TIGR00653 205913002388 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205913002389 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205913002390 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 205913002391 Membrane transport protein; Region: Mem_trans; cl09117 205913002392 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 205913002393 putative CoA binding site [chemical binding]; other site 205913002394 putative trimer interface [polypeptide binding]; other site 205913002395 maltose O-acetyltransferase; Provisional; Region: PRK10092 205913002396 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 205913002397 active site 205913002398 substrate binding site [chemical binding]; other site 205913002399 trimer interface [polypeptide binding]; other site 205913002400 CoA binding site [chemical binding]; other site 205913002401 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 205913002402 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205913002403 minor groove reading motif; other site 205913002404 helix-hairpin-helix signature motif; other site 205913002405 active site 205913002406 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 205913002407 MatE; Region: MatE; pfam01554 205913002408 MatE; Region: MatE; pfam01554 205913002409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913002410 Walker A/P-loop; other site 205913002411 ATP binding site [chemical binding]; other site 205913002412 Q-loop/lid; other site 205913002413 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913002414 ABC transporter signature motif; other site 205913002415 Walker B; other site 205913002416 D-loop; other site 205913002417 H-loop/switch region; other site 205913002418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913002419 Walker A/P-loop; other site 205913002420 ATP binding site [chemical binding]; other site 205913002421 Q-loop/lid; other site 205913002422 ABC transporter signature motif; other site 205913002423 Walker B; other site 205913002424 D-loop; other site 205913002425 H-loop/switch region; other site 205913002426 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913002427 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 205913002428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913002429 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 205913002430 DNA binding residues [nucleotide binding] 205913002431 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913002432 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 205913002433 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205913002434 catalytic Zn binding site [ion binding]; other site 205913002435 NAD(P) binding site [chemical binding]; other site 205913002436 structural Zn binding site [ion binding]; other site 205913002437 CrcB-like protein; Region: CRCB; cl09114 205913002438 CrcB-like protein; Region: CRCB; cl09114 205913002439 GtrA-like protein; Region: GtrA; cl00971 205913002440 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 205913002441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205913002442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913002443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913002444 dimerization interface [polypeptide binding]; other site 205913002445 elongation factor Tu; Reviewed; Region: PRK00049 205913002446 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 205913002447 G1 box; other site 205913002448 GEF interaction site [polypeptide binding]; other site 205913002449 GTP/Mg2+ binding site [chemical binding]; other site 205913002450 Switch I region; other site 205913002451 G2 box; other site 205913002452 G3 box; other site 205913002453 Switch II region; other site 205913002454 G4 box; other site 205913002455 G5 box; other site 205913002456 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 205913002457 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 205913002458 Antibiotic Binding Site [chemical binding]; other site 205913002459 elongation factor G; Reviewed; Region: PRK00007 205913002460 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 205913002461 G1 box; other site 205913002462 putative GEF interaction site [polypeptide binding]; other site 205913002463 GTP/Mg2+ binding site [chemical binding]; other site 205913002464 Switch I region; other site 205913002465 G2 box; other site 205913002466 G3 box; other site 205913002467 Switch II region; other site 205913002468 G4 box; other site 205913002469 G5 box; other site 205913002470 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 205913002471 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 205913002472 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 205913002473 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 205913002474 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 205913002475 16S rRNA interaction site [nucleotide binding]; other site 205913002476 streptomycin interaction site [chemical binding]; other site 205913002477 23S rRNA interaction site [nucleotide binding]; other site 205913002478 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 205913002479 Membrane transport protein; Region: Mem_trans; cl09117 205913002480 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913002481 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 205913002482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913002483 catalytic residue [active] 205913002484 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 205913002485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205913002486 putative ADP-binding pocket [chemical binding]; other site 205913002487 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 205913002488 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 205913002489 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 205913002490 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 205913002491 ATP binding site [chemical binding]; other site 205913002492 active site 205913002493 substrate binding site [chemical binding]; other site 205913002494 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 205913002495 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019 205913002496 dimerization interface [polypeptide binding]; other site 205913002497 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 205913002498 dimerization interface [polypeptide binding]; other site 205913002499 ATP binding site [chemical binding]; other site 205913002500 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 205913002501 dimerization interface [polypeptide binding]; other site 205913002502 ATP binding site [chemical binding]; other site 205913002503 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 205913002504 putative active site [active] 205913002505 catalytic triad [active] 205913002506 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913002507 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 205913002508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913002509 non-specific DNA binding site [nucleotide binding]; other site 205913002510 salt bridge; other site 205913002511 sequence-specific DNA binding site [nucleotide binding]; other site 205913002512 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 205913002513 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 205913002514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913002515 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 205913002516 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205913002517 dimerization interface [polypeptide binding]; other site 205913002518 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205913002519 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 205913002520 active site 205913002521 catalytic tetrad [active] 205913002522 DNA polymerase IV; Reviewed; Region: PRK03103 205913002523 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 205913002524 active site 205913002525 DNA binding site [nucleotide binding] 205913002526 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 205913002527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913002528 oligomerization interface [polypeptide binding]; other site 205913002529 active site 205913002530 NAD+ binding site [chemical binding]; other site 205913002531 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 205913002532 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 205913002533 active site 205913002534 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 205913002535 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 205913002536 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205913002537 substrate binding pocket [chemical binding]; other site 205913002538 membrane-bound complex binding site; other site 205913002539 hinge residues; other site 205913002540 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205913002541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913002542 dimer interface [polypeptide binding]; other site 205913002543 conserved gate region; other site 205913002544 putative PBP binding loops; other site 205913002545 ABC-ATPase subunit interface; other site 205913002546 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205913002547 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 205913002548 Walker A/P-loop; other site 205913002549 ATP binding site [chemical binding]; other site 205913002550 Q-loop/lid; other site 205913002551 ABC transporter signature motif; other site 205913002552 Walker B; other site 205913002553 D-loop; other site 205913002554 H-loop/switch region; other site 205913002555 amidophosphoribosyltransferase; Provisional; Region: PRK07272 205913002556 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 205913002557 active site 205913002558 tetramer interface [polypeptide binding]; other site 205913002559 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913002560 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 205913002561 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 205913002562 dimerization interface [polypeptide binding]; other site 205913002563 putative ATP binding site [chemical binding]; other site 205913002564 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 205913002565 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 205913002566 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 205913002567 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 205913002568 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 205913002569 NAD(P) binding site [chemical binding]; other site 205913002570 catalytic residues [active] 205913002571 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 205913002572 Sulfatase; Region: Sulfatase; cl10460 205913002573 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 205913002574 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205913002575 metal binding site [ion binding]; metal-binding site 205913002576 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 205913002577 metal binding site 2 [ion binding]; metal-binding site 205913002578 putative DNA binding helix; other site 205913002579 metal binding site 1 [ion binding]; metal-binding site 205913002580 dimer interface [polypeptide binding]; other site 205913002581 structural Zn2+ binding site [ion binding]; other site 205913002582 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 205913002583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913002584 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 205913002585 AIR carboxylase; Region: AIRC; cl00310 205913002586 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205913002587 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 205913002588 NAD(P) binding site [chemical binding]; other site 205913002589 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 205913002590 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 205913002591 TPP-binding site; other site 205913002592 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205913002593 PYR/PP interface [polypeptide binding]; other site 205913002594 dimer interface [polypeptide binding]; other site 205913002595 TPP binding site [chemical binding]; other site 205913002596 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205913002597 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 205913002598 FtsX-like permease family; Region: FtsX; pfam02687 205913002599 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 205913002600 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913002601 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205913002602 Walker A/P-loop; other site 205913002603 ATP binding site [chemical binding]; other site 205913002604 Q-loop/lid; other site 205913002605 ABC transporter signature motif; other site 205913002606 Walker B; other site 205913002607 D-loop; other site 205913002608 H-loop/switch region; other site 205913002609 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913002610 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 205913002611 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 205913002612 putative active site [active] 205913002613 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 205913002614 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 205913002615 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to...; Region: YbiR_permease; cd01117 205913002616 transmembrane helices; other site 205913002617 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 205913002618 catalytic nucleophile [active] 205913002619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205913002620 DNA-binding site [nucleotide binding]; DNA binding site 205913002621 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 205913002622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913002623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002624 homodimer interface [polypeptide binding]; other site 205913002625 catalytic residue [active] 205913002626 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 205913002627 predicted active site [active] 205913002628 catalytic triad [active] 205913002629 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 205913002630 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 205913002631 active site 205913002632 multimer interface [polypeptide binding]; other site 205913002633 DNA primase, catalytic core; Region: dnaG; TIGR01391 205913002634 CHC2 zinc finger; Region: zf-CHC2; cl02597 205913002635 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 205913002636 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 205913002637 active site 205913002638 metal binding site [ion binding]; metal-binding site 205913002639 interdomain interaction site; other site 205913002640 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 205913002641 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205913002642 alanine racemase; Reviewed; Region: alr; PRK00053 205913002643 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 205913002644 active site 205913002645 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205913002646 dimer interface [polypeptide binding]; other site 205913002647 substrate binding site [chemical binding]; other site 205913002648 catalytic residues [active] 205913002649 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 205913002650 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 205913002651 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 205913002652 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 205913002653 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 205913002654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913002655 ATP binding site [chemical binding]; other site 205913002656 putative Mg++ binding site [ion binding]; other site 205913002657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913002658 nucleotide binding region [chemical binding]; other site 205913002659 ATP-binding site [chemical binding]; other site 205913002660 RQC domain; Region: RQC; pfam09382 205913002661 HRDC domain; Region: HRDC; cl02578 205913002662 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 205913002663 cystathionine gamma-synthase; Provisional; Region: PRK07811 205913002664 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 205913002665 homodimer interface [polypeptide binding]; other site 205913002666 substrate-cofactor binding pocket; other site 205913002667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002668 catalytic residue [active] 205913002669 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 205913002670 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 205913002671 dimer interface [polypeptide binding]; other site 205913002672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002673 catalytic residue [active] 205913002674 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 205913002675 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205913002676 Walker A/P-loop; other site 205913002677 ATP binding site [chemical binding]; other site 205913002678 Q-loop/lid; other site 205913002679 ABC transporter signature motif; other site 205913002680 Walker B; other site 205913002681 D-loop; other site 205913002682 H-loop/switch region; other site 205913002683 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 205913002684 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 205913002685 Walker A/P-loop; other site 205913002686 ATP binding site [chemical binding]; other site 205913002687 Q-loop/lid; other site 205913002688 ABC transporter signature motif; other site 205913002689 Walker B; other site 205913002690 D-loop; other site 205913002691 H-loop/switch region; other site 205913002692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 205913002693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 205913002694 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205913002695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 205913002696 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 205913002697 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205913002698 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 205913002699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913002700 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913002701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913002702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913002703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913002704 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 205913002705 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 205913002706 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913002707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913002708 DNA binding site [nucleotide binding] 205913002709 domain linker motif; other site 205913002710 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913002711 ligand binding site [chemical binding]; other site 205913002712 dimerization interface [polypeptide binding]; other site 205913002713 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 205913002714 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 205913002715 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 205913002716 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913002717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913002718 dimer interface [polypeptide binding]; other site 205913002719 conserved gate region; other site 205913002720 putative PBP binding loops; other site 205913002721 ABC-ATPase subunit interface; other site 205913002722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913002723 dimer interface [polypeptide binding]; other site 205913002724 conserved gate region; other site 205913002725 putative PBP binding loops; other site 205913002726 ABC-ATPase subunit interface; other site 205913002727 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913002728 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913002729 DNA binding site [nucleotide binding] 205913002730 domain linker motif; other site 205913002731 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 205913002732 ligand binding site [chemical binding]; other site 205913002733 dimerization interface (open form) [polypeptide binding]; other site 205913002734 dimerization interface (closed form) [polypeptide binding]; other site 205913002735 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 205913002736 active site 205913002737 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 205913002738 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 205913002739 glutaminase active site [active] 205913002740 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 205913002741 dimer interface [polypeptide binding]; other site 205913002742 active site 205913002743 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 205913002744 dimer interface [polypeptide binding]; other site 205913002745 active site 205913002746 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205913002747 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 205913002748 Walker A/P-loop; other site 205913002749 ATP binding site [chemical binding]; other site 205913002750 Q-loop/lid; other site 205913002751 ABC transporter signature motif; other site 205913002752 Walker B; other site 205913002753 D-loop; other site 205913002754 H-loop/switch region; other site 205913002755 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205913002756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913002757 dimer interface [polypeptide binding]; other site 205913002758 conserved gate region; other site 205913002759 putative PBP binding loops; other site 205913002760 ABC-ATPase subunit interface; other site 205913002761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 205913002762 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205913002763 substrate binding pocket [chemical binding]; other site 205913002764 membrane-bound complex binding site; other site 205913002765 hinge residues; other site 205913002766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 205913002767 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205913002768 substrate binding pocket [chemical binding]; other site 205913002769 membrane-bound complex binding site; other site 205913002770 hinge residues; other site 205913002771 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 205913002772 SmpB-tmRNA interface; other site 205913002773 NlpC/P60 family; Region: NLPC_P60; cl11438 205913002774 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 205913002775 FtsX-like permease family; Region: FtsX; pfam02687 205913002776 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 205913002777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913002778 Walker A/P-loop; other site 205913002779 ATP binding site [chemical binding]; other site 205913002780 Q-loop/lid; other site 205913002781 ABC transporter signature motif; other site 205913002782 Walker B; other site 205913002783 D-loop; other site 205913002784 H-loop/switch region; other site 205913002785 peptide chain release factor 2; Validated; Region: prfB; PRK00578 205913002786 RF-1 domain; Region: RF-1; cl02875 205913002787 RF-1 domain; Region: RF-1; cl02875 205913002788 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 205913002789 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 205913002790 active site 205913002791 substrate binding site [chemical binding]; other site 205913002792 catalytic site [active] 205913002793 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 205913002794 active site 205913002795 catalytic residues [active] 205913002796 metal binding site [ion binding]; metal-binding site 205913002797 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 205913002798 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 205913002799 active site 205913002800 substrate binding site [chemical binding]; other site 205913002801 metal binding site [ion binding]; metal-binding site 205913002802 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 205913002803 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 205913002804 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 205913002805 Zn binding site [ion binding]; other site 205913002806 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 205913002807 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 205913002808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 205913002809 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 205913002810 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 205913002811 dihydrodipicolinate synthase; Region: dapA; TIGR00674 205913002812 dimer interface [polypeptide binding]; other site 205913002813 active site 205913002814 catalytic residue [active] 205913002815 dihydrodipicolinate reductase; Provisional; Region: PRK00048 205913002816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913002817 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 205913002818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913002819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002820 UvrD/REP helicase; Region: UvrD-helicase; cl14126 205913002821 UvrD/REP helicase; Region: UvrD-helicase; cl14126 205913002822 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 205913002823 DNA helicase IV; Provisional; Region: helD; PRK11054 205913002824 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 205913002825 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205913002826 UvrD/REP helicase; Region: UvrD-helicase; cl14126 205913002827 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 205913002828 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 205913002829 Protein kinase domain; Region: Pkinase; pfam00069 205913002830 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205913002831 active site 205913002832 ATP binding site [chemical binding]; other site 205913002833 substrate binding site [chemical binding]; other site 205913002834 activation loop (A-loop); other site 205913002835 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205913002836 Interdomain contacts; other site 205913002837 Cytokine receptor motif; other site 205913002838 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205913002839 Interdomain contacts; other site 205913002840 Cytokine receptor motif; other site 205913002841 MoxR-like ATPases [General function prediction only]; Region: COG0714 205913002842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913002843 Walker A motif; other site 205913002844 ATP binding site [chemical binding]; other site 205913002845 Walker B motif; other site 205913002846 arginine finger; other site 205913002847 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 205913002848 Protein of unknown function DUF58; Region: DUF58; pfam01882 205913002849 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 205913002850 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 205913002851 Active site [active] 205913002852 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913002853 phosphopeptide binding site; other site 205913002854 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 205913002855 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 205913002856 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 205913002857 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 205913002858 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 205913002859 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 205913002860 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 205913002861 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 205913002862 DNA binding site [nucleotide binding] 205913002863 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 205913002864 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 205913002865 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 205913002866 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 205913002867 RPB1 interaction site [polypeptide binding]; other site 205913002868 RPB10 interaction site [polypeptide binding]; other site 205913002869 RPB11 interaction site [polypeptide binding]; other site 205913002870 RPB3 interaction site [polypeptide binding]; other site 205913002871 RPB12 interaction site [polypeptide binding]; other site 205913002872 Alphaherpesvirus tegument protein US9; Region: Herpes_US9; pfam06072 205913002873 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205913002874 minor groove reading motif; other site 205913002875 helix-hairpin-helix signature motif; other site 205913002876 active site 205913002877 FES domain; Region: FES; smart00525 205913002878 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205913002879 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 205913002880 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 205913002881 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205913002882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002883 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 205913002884 galactokinase; Provisional; Region: PRK05322 205913002885 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 205913002886 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 205913002887 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 205913002888 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 205913002889 dimer interface [polypeptide binding]; other site 205913002890 active site 205913002891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913002892 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 205913002893 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 205913002894 quinone interaction residues [chemical binding]; other site 205913002895 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 205913002896 active site 205913002897 catalytic residues [active] 205913002898 FMN binding site [chemical binding]; other site 205913002899 substrate binding site [chemical binding]; other site 205913002900 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205913002901 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 205913002902 active site 205913002903 FMN binding site [chemical binding]; other site 205913002904 substrate binding site [chemical binding]; other site 205913002905 homotetramer interface [polypeptide binding]; other site 205913002906 catalytic residue [active] 205913002907 Transglycosylase; Region: Transgly; cl07896 205913002908 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 205913002909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 205913002910 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 205913002911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205913002912 ligand binding site [chemical binding]; other site 205913002913 flexible hinge region; other site 205913002914 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205913002915 putative switch regulator; other site 205913002916 non-specific DNA interactions [nucleotide binding]; other site 205913002917 DNA binding site [nucleotide binding] 205913002918 sequence specific DNA binding site [nucleotide binding]; other site 205913002919 putative cAMP binding site [chemical binding]; other site 205913002920 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 205913002921 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 205913002922 isocitrate dehydrogenase; Validated; Region: PRK06451 205913002923 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 205913002924 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913002925 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012 205913002926 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 205913002927 lipoyl attachment site [posttranslational modification]; other site 205913002928 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 205913002929 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 205913002930 putative NADH binding site [chemical binding]; other site 205913002931 putative active site [active] 205913002932 nudix motif; other site 205913002933 putative metal binding site [ion binding]; other site 205913002934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205913002935 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 205913002936 catalytic residues [active] 205913002937 Domain of unknown function (DUF348); Region: DUF348; pfam03990 205913002938 G5 domain; Region: G5; pfam07501 205913002939 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 205913002940 catalytic residue [active] 205913002941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 205913002942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913002943 Integrase core domain; Region: rve; cl01316 205913002944 transposase/IS protein; Provisional; Region: PRK09183 205913002945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913002946 Walker A motif; other site 205913002947 ATP binding site [chemical binding]; other site 205913002948 Walker B motif; other site 205913002949 putative transposase OrfB; Reviewed; Region: PHA02517 205913002950 Integrase core domain; Region: rve; cl01316 205913002951 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205913002952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002953 putative substrate translocation pore; other site 205913002954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002955 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 205913002956 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913002957 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 205913002958 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 205913002959 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913002960 active site 205913002961 catalytic tetrad [active] 205913002962 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 205913002963 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 205913002964 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 205913002965 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913002966 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913002967 DNA binding site [nucleotide binding] 205913002968 domain linker motif; other site 205913002969 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913002970 ligand binding site [chemical binding]; other site 205913002971 dimerization interface [polypeptide binding]; other site 205913002972 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 205913002973 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 205913002974 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 205913002975 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 205913002976 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913002977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913002978 dimer interface [polypeptide binding]; other site 205913002979 conserved gate region; other site 205913002980 putative PBP binding loops; other site 205913002981 ABC-ATPase subunit interface; other site 205913002982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913002983 dimer interface [polypeptide binding]; other site 205913002984 conserved gate region; other site 205913002985 putative PBP binding loops; other site 205913002986 ABC-ATPase subunit interface; other site 205913002987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913002988 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913002989 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 205913002990 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 205913002991 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913002992 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913002993 Walker A/P-loop; other site 205913002994 ATP binding site [chemical binding]; other site 205913002995 Q-loop/lid; other site 205913002996 ABC transporter signature motif; other site 205913002997 Walker B; other site 205913002998 D-loop; other site 205913002999 H-loop/switch region; other site 205913003000 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913003001 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913003002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913003003 Walker A/P-loop; other site 205913003004 ATP binding site [chemical binding]; other site 205913003005 Q-loop/lid; other site 205913003006 ABC transporter signature motif; other site 205913003007 Walker B; other site 205913003008 D-loop; other site 205913003009 H-loop/switch region; other site 205913003010 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 205913003011 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913003012 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913003013 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205913003014 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913003015 Walker A/P-loop; other site 205913003016 ATP binding site [chemical binding]; other site 205913003017 Q-loop/lid; other site 205913003018 ABC transporter signature motif; other site 205913003019 Walker B; other site 205913003020 D-loop; other site 205913003021 H-loop/switch region; other site 205913003022 FtsX-like permease family; Region: FtsX; pfam02687 205913003023 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 205913003024 FtsX-like permease family; Region: FtsX; pfam02687 205913003025 Peptidase C26; Region: Peptidase_C26; pfam07722 205913003026 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 205913003027 catalytic triad [active] 205913003028 L-arabinose isomerase; Provisional; Region: PRK02929 205913003029 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947 205913003030 hexamer (dimer of trimers) interface [polypeptide binding]; other site 205913003031 trimer interface [polypeptide binding]; other site 205913003032 substrate binding site [chemical binding]; other site 205913003033 Mn binding site [ion binding]; other site 205913003034 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 205913003035 intersubunit interface [polypeptide binding]; other site 205913003036 active site 205913003037 Zn2+ binding site [ion binding]; other site 205913003038 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 205913003039 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913003040 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 205913003041 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003042 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003043 DNA binding site [nucleotide binding] 205913003044 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 205913003045 ligand binding site [chemical binding]; other site 205913003046 dimerization interface (open form) [polypeptide binding]; other site 205913003047 dimerization interface (closed form) [polypeptide binding]; other site 205913003048 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 205913003049 RNA/DNA hybrid binding site [nucleotide binding]; other site 205913003050 active site 205913003051 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 205913003052 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205913003053 Catalytic site [active] 205913003054 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 205913003055 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 205913003056 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 205913003057 active site 205913003058 dimer interface [polypeptide binding]; other site 205913003059 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 205913003060 dimer interface [polypeptide binding]; other site 205913003061 active site 205913003062 Membrane transport protein; Region: Mem_trans; cl09117 205913003063 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 205913003064 FemAB family; Region: FemAB; cl11444 205913003065 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 205913003066 FemAB family; Region: FemAB; cl11444 205913003067 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 205913003068 FemAB family; Region: FemAB; cl11444 205913003069 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 205913003070 active site 205913003071 dimerization interface [polypeptide binding]; other site 205913003072 ribonuclease PH; Reviewed; Region: rph; PRK00173 205913003073 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 205913003074 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 205913003075 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 205913003076 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 205913003077 active site 205913003078 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 205913003079 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 205913003080 DNA binding residues [nucleotide binding] 205913003081 putative dimer interface [polypeptide binding]; other site 205913003082 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 205913003083 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 205913003084 active site 205913003085 catalytic tetrad [active] 205913003086 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 205913003087 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 205913003088 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 205913003089 active site 205913003090 (T/H)XGH motif; other site 205913003091 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205913003092 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 205913003093 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 205913003094 ribonuclease III; Reviewed; Region: rnc; PRK00102 205913003095 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 205913003096 dimerization interface [polypeptide binding]; other site 205913003097 active site 205913003098 metal binding site [ion binding]; metal-binding site 205913003099 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cl00054 205913003100 dsRNA binding site [nucleotide binding]; other site 205913003101 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 205913003102 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 205913003103 PYR/PP interface [polypeptide binding]; other site 205913003104 dimer interface [polypeptide binding]; other site 205913003105 TPP binding site [chemical binding]; other site 205913003106 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 205913003107 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 205913003108 TPP-binding site [chemical binding]; other site 205913003109 dimer interface [polypeptide binding]; other site 205913003110 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 205913003111 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 205913003112 putative valine binding site [chemical binding]; other site 205913003113 dimer interface [polypeptide binding]; other site 205913003114 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 205913003115 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 205913003116 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 205913003117 oligomeric interface; other site 205913003118 putative active site [active] 205913003119 homodimer interface [polypeptide binding]; other site 205913003120 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913003121 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 205913003122 ABC transporter; Region: ABC_tran_2; pfam12848 205913003123 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 205913003124 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 205913003125 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 205913003126 catalytic triad [active] 205913003127 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 205913003128 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205913003129 active site 205913003130 HIGH motif; other site 205913003131 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205913003132 KMSKS motif; other site 205913003133 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 205913003134 tRNA binding surface [nucleotide binding]; other site 205913003135 anticodon binding site; other site 205913003136 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 205913003137 Cation efflux family; Region: Cation_efflux; cl00316 205913003138 signal recognition particle protein; Provisional; Region: PRK10867 205913003139 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 205913003140 P loop; other site 205913003141 GTP binding site [chemical binding]; other site 205913003142 Signal peptide binding domain; Region: SRP_SPB; pfam02978 205913003143 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205913003144 putative catalytic site [active] 205913003145 putative metal binding site [ion binding]; other site 205913003146 putative phosphate binding site [ion binding]; other site 205913003147 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 205913003148 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 205913003149 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 205913003150 RimM N-terminal domain; Region: RimM; pfam01782 205913003151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 205913003152 HipA-like N-terminal domain; Region: HipA_N; pfam07805 205913003153 HipA-like C-terminal domain; Region: HipA_C; pfam07804 205913003154 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913003155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913003156 dimer interface [polypeptide binding]; other site 205913003157 conserved gate region; other site 205913003158 putative PBP binding loops; other site 205913003159 ABC-ATPase subunit interface; other site 205913003160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913003161 dimer interface [polypeptide binding]; other site 205913003162 conserved gate region; other site 205913003163 putative PBP binding loops; other site 205913003164 ABC-ATPase subunit interface; other site 205913003165 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913003166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913003167 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003169 DNA binding site [nucleotide binding] 205913003170 domain linker motif; other site 205913003171 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913003172 dimerization interface [polypeptide binding]; other site 205913003173 ligand binding site [chemical binding]; other site 205913003174 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_CaPnhB; cd02650 205913003175 active site 205913003176 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 205913003177 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913003178 active site 205913003179 catalytic tetrad [active] 205913003180 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 205913003181 Predicted membrane protein [Function unknown]; Region: COG4907 205913003182 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 205913003183 Predicted membrane protein [Function unknown]; Region: COG4907 205913003184 LemA family; Region: LemA; cl00742 205913003185 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 205913003186 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 205913003187 Walker A/P-loop; other site 205913003188 ATP binding site [chemical binding]; other site 205913003189 Q-loop/lid; other site 205913003190 ABC transporter signature motif; other site 205913003191 Walker B; other site 205913003192 D-loop; other site 205913003193 H-loop/switch region; other site 205913003194 sulfate transport protein; Provisional; Region: cysT; CHL00187 205913003195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913003196 dimer interface [polypeptide binding]; other site 205913003197 conserved gate region; other site 205913003198 putative PBP binding loops; other site 205913003199 ABC-ATPase subunit interface; other site 205913003200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913003201 dimer interface [polypeptide binding]; other site 205913003202 conserved gate region; other site 205913003203 putative PBP binding loops; other site 205913003204 ABC-ATPase subunit interface; other site 205913003205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913003206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913003207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913003208 active site 205913003209 phosphorylation site [posttranslational modification] 205913003210 intermolecular recognition site; other site 205913003211 dimerization interface [polypeptide binding]; other site 205913003212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 205913003213 DNA binding site [nucleotide binding] 205913003214 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205913003215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 205913003216 dimer interface [polypeptide binding]; other site 205913003217 phosphorylation site [posttranslational modification] 205913003218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913003219 ATP binding site [chemical binding]; other site 205913003220 Mg2+ binding site [ion binding]; other site 205913003221 G-X-G motif; other site 205913003222 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 205913003223 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 205913003224 NeuB family; Region: NeuB; cl00496 205913003225 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205913003226 NeuB family; Region: NeuB; cl00496 205913003227 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205913003228 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 205913003229 trimer interface [polypeptide binding]; other site 205913003230 active site 205913003231 G bulge; other site 205913003232 MAEBL; Provisional; Region: PTZ00121 205913003233 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 205913003234 putative substrate binding pocket [chemical binding]; other site 205913003235 AC domain interface; other site 205913003236 catalytic triad [active] 205913003237 AB domain interface; other site 205913003238 interchain disulfide; other site 205913003239 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 205913003240 substrate binding site [chemical binding]; other site 205913003241 dimer interface [polypeptide binding]; other site 205913003242 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 205913003243 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 205913003244 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 205913003245 Peptidase family U32; Region: Peptidase_U32; cl03113 205913003246 putative protease; Provisional; Region: PRK15452 205913003247 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 205913003248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 205913003249 S-adenosylmethionine binding site [chemical binding]; other site 205913003250 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 205913003251 ssDNA binding site; other site 205913003252 generic binding surface II; other site 205913003253 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 205913003254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913003255 ATP binding site [chemical binding]; other site 205913003256 putative Mg++ binding site [ion binding]; other site 205913003257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913003258 nucleotide binding region [chemical binding]; other site 205913003259 ATP-binding site [chemical binding]; other site 205913003260 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 205913003261 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 205913003262 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 205913003263 substrate binding site [chemical binding]; other site 205913003264 ATP binding site [chemical binding]; other site 205913003265 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 205913003266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003267 putative substrate translocation pore; other site 205913003268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205913003269 dimerization interface [polypeptide binding]; other site 205913003270 putative DNA binding site [nucleotide binding]; other site 205913003271 putative Zn2+ binding site [ion binding]; other site 205913003272 Predicted permease; Region: DUF318; cl00487 205913003273 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205913003274 Low molecular weight phosphatase family; Region: LMWPc; cl00105 205913003275 Membrane transport protein; Region: Mem_trans; cl09117 205913003276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913003277 non-specific DNA binding site [nucleotide binding]; other site 205913003278 salt bridge; other site 205913003279 sequence-specific DNA binding site [nucleotide binding]; other site 205913003280 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 205913003281 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 205913003282 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 205913003283 DNA binding site [nucleotide binding] 205913003284 active site 205913003285 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 205913003286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913003287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913003288 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 205913003289 Aspartase; Region: Aspartase; cd01357 205913003290 active sites [active] 205913003291 tetramer interface [polypeptide binding]; other site 205913003292 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205913003293 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 205913003294 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205913003295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913003296 Walker A/P-loop; other site 205913003297 ATP binding site [chemical binding]; other site 205913003298 Q-loop/lid; other site 205913003299 ABC transporter signature motif; other site 205913003300 Walker B; other site 205913003301 D-loop; other site 205913003302 H-loop/switch region; other site 205913003303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913003304 dimer interface [polypeptide binding]; other site 205913003305 conserved gate region; other site 205913003306 putative PBP binding loops; other site 205913003307 ABC-ATPase subunit interface; other site 205913003308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 205913003309 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205913003310 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 205913003311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913003312 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 205913003313 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 205913003314 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 205913003315 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 205913003316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913003317 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 205913003318 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205913003319 putative acyl-acceptor binding pocket; other site 205913003320 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205913003321 homotrimer interaction site [polypeptide binding]; other site 205913003322 putative active site [active] 205913003323 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 205913003324 putative active site [active] 205913003325 putative metal binding residues [ion binding]; other site 205913003326 signature motif; other site 205913003327 putative dimer interface [polypeptide binding]; other site 205913003328 putative phosphate binding site [ion binding]; other site 205913003329 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205913003330 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 205913003331 Protein of unknown function DUF91; Region: DUF91; cl00709 205913003332 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 205913003333 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 205913003334 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205913003335 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 205913003336 alpha subunit interaction interface [polypeptide binding]; other site 205913003337 Walker A motif; other site 205913003338 ATP binding site [chemical binding]; other site 205913003339 Walker B motif; other site 205913003340 inhibitor binding site; inhibition site 205913003341 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205913003342 ATP synthase; Region: ATP-synt; cl00365 205913003343 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 205913003344 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205913003345 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 205913003346 beta subunit interaction interface [polypeptide binding]; other site 205913003347 Walker A motif; other site 205913003348 ATP binding site [chemical binding]; other site 205913003349 Walker B motif; other site 205913003350 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205913003351 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 205913003352 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 205913003353 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 205913003354 ATP synthase subunit C; Region: ATP-synt_C; cl00466 205913003355 ATP synthase A chain; Region: ATP-synt_A; cl00413 205913003356 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 205913003357 proposed active site lysine [active] 205913003358 conserved cys residue [active] 205913003359 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913003360 Phage integrase family; Region: Phage_integrase; pfam00589 205913003361 DNA binding site [nucleotide binding] 205913003362 Int/Topo IB signature motif; other site 205913003363 active site 205913003364 Protein of unknown function (DUF497); Region: DUF497; cl01108 205913003365 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl...; Region: GH25_LysA-like; cd06417 205913003366 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 205913003367 active site 205913003368 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230 205913003369 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 205913003370 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 205913003371 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 205913003372 putative active site [active] 205913003373 putative NTP binding site [chemical binding]; other site 205913003374 putative nucleic acid binding site [nucleotide binding]; other site 205913003375 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 205913003376 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 205913003377 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 205913003378 Phage-related protein [Function unknown]; Region: COG5412 205913003379 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 205913003380 membrane protein P6; Region: PHA01399 205913003381 Phage-related protein [Function unknown]; Region: COG5412 205913003382 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 205913003383 Phage capsid family; Region: Phage_capsid; pfam05065 205913003384 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 205913003385 Phage terminase large subunit; Region: Terminase_3; cl12054 205913003386 Transcription factor WhiB; Region: Whib; pfam02467 205913003387 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 205913003388 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 205913003389 putative active site [active] 205913003390 putative substrate binding site [chemical binding]; other site 205913003391 catalytic site [active] 205913003392 dimer interface [polypeptide binding]; other site 205913003393 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205913003394 dimer interface [polypeptide binding]; other site 205913003395 ssDNA binding site [nucleotide binding]; other site 205913003396 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913003397 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 205913003398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913003399 non-specific DNA binding site [nucleotide binding]; other site 205913003400 salt bridge; other site 205913003401 sequence-specific DNA binding site [nucleotide binding]; other site 205913003402 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 205913003403 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 205913003404 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913003405 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913003406 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 205913003407 dimer interface [polypeptide binding]; other site 205913003408 substrate binding site [chemical binding]; other site 205913003409 metal binding sites [ion binding]; metal-binding site 205913003410 Domain of unknown function DUF; Region: DUF204; pfam02659 205913003411 Domain of unknown function DUF; Region: DUF204; pfam02659 205913003412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913003413 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 205913003414 DNA binding site [nucleotide binding] 205913003415 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 205913003416 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205913003417 minor groove reading motif; other site 205913003418 helix-hairpin-helix signature motif; other site 205913003419 substrate binding pocket [chemical binding]; other site 205913003420 active site 205913003421 FES domain; Region: FES; smart00525 205913003422 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 205913003423 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205913003424 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 205913003425 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913003426 active site 205913003427 HIGH motif; other site 205913003428 nucleotide binding site [chemical binding]; other site 205913003429 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913003430 active site 205913003431 KMSKS motif; other site 205913003432 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 205913003433 tRNA binding surface [nucleotide binding]; other site 205913003434 anticodon binding site; other site 205913003435 Chorismate mutase type II; Region: CM_2; cl00693 205913003436 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 205913003437 transcription termination factor Rho; Provisional; Region: PRK12608 205913003438 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 205913003439 RNA binding site [nucleotide binding]; other site 205913003440 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 205913003441 multimer interface [polypeptide binding]; other site 205913003442 Walker A motif; other site 205913003443 ATP binding site [chemical binding]; other site 205913003444 Walker B motif; other site 205913003445 hypothetical protein; Provisional; Region: PRK07208 205913003446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913003447 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 205913003448 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 205913003449 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 205913003450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205913003451 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 205913003452 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 205913003453 GatB domain; Region: GatB_Yqey; cl11497 205913003454 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205913003455 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 205913003456 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 205913003457 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205913003458 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913003459 RmuC family; Region: RmuC; pfam02646 205913003460 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 205913003461 putative homotetramer interface [polypeptide binding]; other site 205913003462 putative homodimer interface [polypeptide binding]; other site 205913003463 putative allosteric switch controlling residues; other site 205913003464 putative metal binding site [ion binding]; other site 205913003465 putative homodimer-homodimer interface [polypeptide binding]; other site 205913003466 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 205913003467 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 205913003468 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913003469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913003470 active site 205913003471 motif I; other site 205913003472 motif II; other site 205913003473 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 205913003474 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 205913003475 amphipathic channel; other site 205913003476 Asn-Pro-Ala signature motifs; other site 205913003477 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 205913003478 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 205913003479 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 205913003480 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 205913003481 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 205913003482 dimerization domain swap beta strand [polypeptide binding]; other site 205913003483 regulatory protein interface [polypeptide binding]; other site 205913003484 active site 205913003485 regulatory phosphorylation site [posttranslational modification]; other site 205913003486 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 205913003487 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 205913003488 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 205913003489 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 205913003490 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205913003491 dimer interface [polypeptide binding]; other site 205913003492 ssDNA binding site [nucleotide binding]; other site 205913003493 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913003494 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 205913003495 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 205913003496 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913003497 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 205913003498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205913003499 catalytic residue [active] 205913003500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 205913003501 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 205913003502 Probable transposase; Region: OrfB_IS605; pfam01385 205913003503 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 205913003504 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 205913003505 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 205913003506 catalytic residues [active] 205913003507 catalytic nucleophile [active] 205913003508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913003509 NAD(P) binding site [chemical binding]; other site 205913003510 active site 205913003511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913003512 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 205913003513 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205913003514 ATP binding site [chemical binding]; other site 205913003515 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl02058 205913003516 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 205913003517 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 205913003518 catalytic triad [active] 205913003519 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 205913003520 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913003521 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 205913003522 replicative DNA helicase; Region: DnaB; TIGR00665 205913003523 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 205913003524 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 205913003525 Walker A motif; other site 205913003526 ATP binding site [chemical binding]; other site 205913003527 Walker B motif; other site 205913003528 DNA binding loops [nucleotide binding] 205913003529 putative efflux protein, MATE family; Region: matE; TIGR00797 205913003530 MatE; Region: MatE; pfam01554 205913003531 MatE; Region: MatE; pfam01554 205913003532 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205913003533 metal binding triad; other site 205913003534 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205913003535 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205913003536 Nitrogen regulatory protein P-II; Region: P-II; cl00412 205913003537 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 205913003538 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 205913003539 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 205913003540 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 205913003541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913003542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913003543 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205913003544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913003545 active site 205913003546 Peptidase family C69; Region: Peptidase_C69; cl01920 205913003547 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 205913003548 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 205913003549 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 205913003550 opcA protein; Region: OpcA; TIGR00534 205913003551 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 205913003552 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 205913003553 putative active site [active] 205913003554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913003555 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 205913003556 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 205913003557 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 205913003558 Predicted membrane protein [Function unknown]; Region: COG1511 205913003559 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 205913003560 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205913003561 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 205913003562 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 205913003563 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205913003564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913003565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913003566 FMN-binding domain; Region: FMN_bind; cl01081 205913003567 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913003568 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205913003569 Walker A/P-loop; other site 205913003570 ATP binding site [chemical binding]; other site 205913003571 Q-loop/lid; other site 205913003572 ABC transporter signature motif; other site 205913003573 Walker B; other site 205913003574 D-loop; other site 205913003575 H-loop/switch region; other site 205913003576 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913003577 FtsX-like permease family; Region: FtsX; pfam02687 205913003578 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913003579 FtsX-like permease family; Region: FtsX; pfam02687 205913003580 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 205913003581 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 205913003582 Fe2+ transport protein; Region: Iron_transport; cl01377 205913003583 Iron permease FTR1 family; Region: FTR1; cl00475 205913003584 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 205913003585 PEGA domain; Region: PEGA; pfam08308 205913003586 Endo-alpha-N-acetylgalactosaminidase glycoside hydrolase; Region: Glyco_hydro_100; pfam12899 205913003587 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 205913003588 electron transport complex protein RnfC; Provisional; Region: PRK05035 205913003589 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 205913003590 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205913003591 HIGH motif; other site 205913003592 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205913003593 active site 205913003594 KMSKS motif; other site 205913003595 Protein of unknown function (DUF805); Region: DUF805; cl01224 205913003596 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 205913003597 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 205913003598 active site 205913003599 phosphate binding residues; other site 205913003600 catalytic residues [active] 205913003601 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913003602 catalytic core [active] 205913003603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913003604 GtrA-like protein; Region: GtrA; cl00971 205913003605 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 205913003606 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913003607 Integrase core domain; Region: rve; cl01316 205913003608 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 205913003609 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 205913003610 Peptidase family C69; Region: Peptidase_C69; cl01920 205913003611 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 205913003612 substrate binding site [chemical binding]; other site 205913003613 DNA polymerase III subunit delta'; Validated; Region: PRK07940 205913003614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913003615 Walker A motif; other site 205913003616 ATP binding site [chemical binding]; other site 205913003617 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913003618 Walker B motif; other site 205913003619 thymidylate kinase; Validated; Region: tmk; PRK00698 205913003620 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 205913003621 TMP-binding site; other site 205913003622 ATP-binding site [chemical binding]; other site 205913003623 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 205913003624 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 205913003625 active site 205913003626 interdomain interaction site; other site 205913003627 putative metal-binding site [ion binding]; other site 205913003628 nucleotide binding site [chemical binding]; other site 205913003629 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 205913003630 domain I; other site 205913003631 phosphate binding site [ion binding]; other site 205913003632 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 205913003633 domain II; other site 205913003634 domain III; other site 205913003635 nucleotide binding site [chemical binding]; other site 205913003636 DNA binding groove [nucleotide binding] 205913003637 catalytic site [active] 205913003638 domain IV; other site 205913003639 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 205913003640 Transglycosylase; Region: Transgly; cl07896 205913003641 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 205913003642 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 205913003643 2-isopropylmalate synthase; Validated; Region: PRK03739 205913003644 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 205913003645 active site 205913003646 catalytic residues [active] 205913003647 metal binding site [ion binding]; metal-binding site 205913003648 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 205913003649 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913003650 metal binding site [ion binding]; metal-binding site 205913003651 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913003652 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 205913003653 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 205913003654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913003655 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 205913003656 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 205913003657 putative allosteric regulatory site; other site 205913003658 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 205913003659 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 205913003660 putative nucleotide binding site [chemical binding]; other site 205913003661 putative catalytic residues [active] 205913003662 putative Mg ion binding site [ion binding]; other site 205913003663 putative aspartate binding site [chemical binding]; other site 205913003664 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913003665 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 205913003666 active site 205913003667 catalytic site [active] 205913003668 recombination protein RecR; Reviewed; Region: recR; PRK00076 205913003669 RecR protein; Region: RecR; pfam02132 205913003670 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 205913003671 putative active site [active] 205913003672 putative metal-binding site [ion binding]; other site 205913003673 tetramer interface [polypeptide binding]; other site 205913003674 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 205913003675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913003676 Walker A motif; other site 205913003677 ATP binding site [chemical binding]; other site 205913003678 Walker B motif; other site 205913003679 arginine finger; other site 205913003680 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 205913003681 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 205913003682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913003683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913003684 diacylglycerol kinase; Reviewed; Region: PRK11914 205913003685 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 205913003686 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 205913003687 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 205913003688 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 205913003689 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 205913003690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913003691 ATP binding site [chemical binding]; other site 205913003692 Walker B motif; other site 205913003693 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 205913003694 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205913003695 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003696 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003697 DNA binding site [nucleotide binding] 205913003698 domain linker motif; other site 205913003699 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913003700 dimerization interface [polypeptide binding]; other site 205913003701 ligand binding site [chemical binding]; other site 205913003702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913003703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913003704 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 205913003705 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 205913003706 active site 205913003707 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913003708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913003709 dimer interface [polypeptide binding]; other site 205913003710 conserved gate region; other site 205913003711 putative PBP binding loops; other site 205913003712 ABC-ATPase subunit interface; other site 205913003713 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205913003714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913003715 dimer interface [polypeptide binding]; other site 205913003716 conserved gate region; other site 205913003717 putative PBP binding loops; other site 205913003718 ABC-ATPase subunit interface; other site 205913003719 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 205913003720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913003721 motif II; other site 205913003722 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 205913003723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913003724 NAD(P) binding site [chemical binding]; other site 205913003725 active site 205913003726 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 205913003727 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 205913003728 putative catalytic cysteine [active] 205913003729 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913003730 Permease family; Region: Xan_ur_permease; pfam00860 205913003731 Sulfate transporter family; Region: Sulfate_transp; cl00967 205913003732 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 205913003733 DNA binding residues [nucleotide binding] 205913003734 putative dimer interface [polypeptide binding]; other site 205913003735 chaperone protein DnaJ; Provisional; Region: PRK10767 205913003736 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 205913003737 HSP70 interaction site [polypeptide binding]; other site 205913003738 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 205913003739 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 205913003740 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 205913003741 dimer interface [polypeptide binding]; other site 205913003742 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 205913003743 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 205913003744 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 205913003745 putative active site [active] 205913003746 putative catalytic site [active] 205913003747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913003748 ABC-ATPase subunit interface; other site 205913003749 putative PBP binding loops; other site 205913003750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003752 DNA binding site [nucleotide binding] 205913003753 domain linker motif; other site 205913003754 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913003755 ligand binding site [chemical binding]; other site 205913003756 dimerization interface [polypeptide binding]; other site 205913003757 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913003758 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 205913003759 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 205913003760 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003761 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003762 DNA binding site [nucleotide binding] 205913003763 domain linker motif; other site 205913003764 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913003765 ligand binding site [chemical binding]; other site 205913003766 dimerization interface [polypeptide binding]; other site 205913003767 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913003768 Predicted membrane-associated trancriptional regulator [Transcription]; Region: COG2512 205913003769 ketol-acid reductoisomerase; Provisional; Region: PRK05479 205913003770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913003771 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 205913003772 ketol-acid reductoisomerase; Provisional; Region: PRK05479 205913003773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913003774 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 205913003775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003776 metabolite-proton symporter; Region: 2A0106; TIGR00883 205913003777 putative substrate translocation pore; other site 205913003778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003780 DNA binding site [nucleotide binding] 205913003781 domain linker motif; other site 205913003782 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 205913003783 dimerization interface [polypeptide binding]; other site 205913003784 ligand binding site [chemical binding]; other site 205913003785 sodium binding site [ion binding]; other site 205913003786 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913003787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003788 sucrose phosphorylase; Provisional; Region: PRK13840 205913003789 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913003790 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 205913003791 putative transposase OrfB; Reviewed; Region: PHA02517 205913003792 Integrase core domain; Region: rve; cl01316 205913003793 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913003794 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913003795 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes...; Region: INT_pAE1; cd01188 205913003796 Int/Topo IB signature motif; other site 205913003797 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 205913003798 Phage integrase family; Region: Phage_integrase; pfam00589 205913003799 Int/Topo IB signature motif; other site 205913003800 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913003801 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913003802 DNA binding site [nucleotide binding] 205913003803 Int/Topo IB signature motif; other site 205913003804 active site 205913003805 putative transposase OrfB; Reviewed; Region: PHA02517 205913003806 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 205913003807 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003808 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003809 DNA binding site [nucleotide binding] 205913003810 domain linker motif; other site 205913003811 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913003812 dimerization interface [polypeptide binding]; other site 205913003813 ligand binding site [chemical binding]; other site 205913003814 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 205913003815 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 205913003816 K+ potassium transporter; Region: K_trans; cl01227 205913003817 K+ potassium transporter; Region: K_trans; cl01227 205913003818 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003819 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003820 DNA binding site [nucleotide binding] 205913003821 domain linker motif; other site 205913003822 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913003823 CrcB-like protein; Region: CRCB; cl09114 205913003824 CrcB-like protein; Region: CRCB; cl09114 205913003825 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-...; Region: EriC; cd01031 205913003826 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 205913003827 Cl- selectivity filter; other site 205913003828 Cl- binding residues [ion binding]; other site 205913003829 pore gating glutamate residue; other site 205913003830 dimer interface [polypeptide binding]; other site 205913003831 H+/Cl- coupling transport residue; other site 205913003832 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 205913003833 adenylosuccinate synthetase; Provisional; Region: PRK01117 205913003834 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 205913003835 GDP-binding site [chemical binding]; other site 205913003836 ACT binding site; other site 205913003837 IMP binding site; other site 205913003838 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 205913003839 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 205913003840 active site 205913003841 intersubunit interface [polypeptide binding]; other site 205913003842 zinc binding site [ion binding]; other site 205913003843 Na+ binding site [ion binding]; other site 205913003844 Peptidase family M48; Region: Peptidase_M48; cl12018 205913003845 ferredoxin-NADP+ reductase; Region: PLN02852 205913003846 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913003847 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 205913003848 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913003849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913003850 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 205913003851 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 205913003852 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 205913003853 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 205913003854 Haemolysin-III related; Region: HlyIII; cl03831 205913003855 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205913003856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205913003857 Domain of unknown function (DUF74); Region: DUF74; cl00426 205913003858 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex; Region: MutH_Sau3AI; cd00583 205913003859 putative DNA-binding cleft [nucleotide binding]; other site 205913003860 putative DNA clevage site; other site 205913003861 molecular lever; other site 205913003862 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 205913003863 putative active site [active] 205913003864 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 205913003865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913003866 cofactor binding site; other site 205913003867 DNA binding site [nucleotide binding] 205913003868 substrate interaction site [chemical binding]; other site 205913003869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913003870 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 205913003871 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913003872 active site 205913003873 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 205913003874 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 205913003875 SelR domain; Region: SelR; cl00369 205913003876 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 205913003877 Predicted esterase [General function prediction only]; Region: COG0627 205913003878 aromatic amino acid exporter; Provisional; Region: PRK11689 205913003879 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 205913003880 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 205913003881 putative dimer interface [polypeptide binding]; other site 205913003882 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 205913003883 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205913003884 metal ion-dependent adhesion site (MIDAS); other site 205913003885 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913003886 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 205913003887 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 205913003888 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913003889 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 205913003890 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913003891 phosphopeptide binding site; other site 205913003892 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913003893 phosphopeptide binding site; other site 205913003894 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 205913003895 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 205913003896 Active site [active] 205913003897 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 205913003898 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 205913003899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 205913003900 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205913003901 active site 205913003902 ATP binding site [chemical binding]; other site 205913003903 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913003904 substrate binding site [chemical binding]; other site 205913003905 activation loop (A-loop); other site 205913003906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205913003907 active site 205913003908 ATP binding site [chemical binding]; other site 205913003909 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913003910 substrate binding site [chemical binding]; other site 205913003911 activation loop (A-loop); other site 205913003912 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 205913003913 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 205913003914 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 205913003915 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 205913003916 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 205913003917 Glutamine amidotransferase class-I; Region: GATase; pfam00117 205913003918 glutamine binding [chemical binding]; other site 205913003919 catalytic triad [active] 205913003920 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 205913003921 active site 205913003922 catalytic site [active] 205913003923 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 205913003924 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 205913003925 Rhomboid family; Region: Rhomboid; cl11446 205913003926 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 205913003927 homodimer interface [polypeptide binding]; other site 205913003928 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 205913003929 active site pocket [active] 205913003930 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 205913003931 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 205913003932 active site 205913003933 HIGH motif; other site 205913003934 dimer interface [polypeptide binding]; other site 205913003935 KMSKS motif; other site 205913003936 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 205913003937 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 205913003938 active site 205913003939 Sodium:solute symporter family; Region: SSF; cl00456 205913003940 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 205913003941 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 205913003942 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 205913003943 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 205913003944 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 205913003945 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913003946 Divergent AAA domain; Region: AAA_4; pfam04326 205913003947 transcriptional repressor UlaR; Provisional; Region: PRK13509 205913003948 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003950 DNA binding site [nucleotide binding] 205913003951 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913003952 dimerization interface [polypeptide binding]; other site 205913003953 ligand binding site [chemical binding]; other site 205913003954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913003956 putative substrate translocation pore; other site 205913003957 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 205913003958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913003959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913003960 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 205913003961 catalytic residue [active] 205913003962 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 205913003963 catalytic residues [active] 205913003964 peroxiredoxin; Region: AhpC; TIGR03137 205913003965 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 205913003966 dimer interface [polypeptide binding]; other site 205913003967 decamer (pentamer of dimers) interface [polypeptide binding]; other site 205913003968 catalytic triad [active] 205913003969 peroxidatic and resolving cysteines [active] 205913003970 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 205913003971 active site clefts [active] 205913003972 zinc binding site [ion binding]; other site 205913003973 dimer interface [polypeptide binding]; other site 205913003974 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 205913003975 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 205913003976 Domain of unknown function DUF21; Region: DUF21; pfam01595 205913003977 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205913003978 Transporter associated domain; Region: CorC_HlyC; pfam03471 205913003979 Ferritin-like domain; Region: Ferritin; pfam00210 205913003980 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 205913003981 dimerization interface [polypeptide binding]; other site 205913003982 DPS ferroxidase diiron center [ion binding]; other site 205913003983 ion pore; other site 205913003984 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913003985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913003986 Integrase core domain; Region: rve; cl01316 205913003987 transposase/IS protein; Provisional; Region: PRK09183 205913003988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913003989 Walker A motif; other site 205913003990 ATP binding site [chemical binding]; other site 205913003991 Walker B motif; other site 205913003992 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 205913003993 Protein of unknown function DUF45; Region: DUF45; cl00636 205913003994 hypothetical protein; Provisional; Region: PRK06062 205913003995 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 205913003996 inhibitor-cofactor binding pocket; inhibition site 205913003997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913003998 catalytic residue [active] 205913003999 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 205913004000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205913004001 DNA-binding site [nucleotide binding]; DNA binding site 205913004002 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913004003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004004 homodimer interface [polypeptide binding]; other site 205913004005 catalytic residue [active] 205913004006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 205913004007 aspartate aminotransferase; Provisional; Region: PRK08361 205913004008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913004009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004010 homodimer interface [polypeptide binding]; other site 205913004011 catalytic residue [active] 205913004012 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 205913004013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004014 glutamate dehydrogenase; Provisional; Region: PRK09414 205913004015 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 205913004016 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 205913004017 NAD(P) binding site [chemical binding]; other site 205913004018 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 205913004019 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 205913004020 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 205913004021 DNA gyrase subunit A; Validated; Region: PRK05560 205913004022 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 205913004023 CAP-like domain; other site 205913004024 Active site [active] 205913004025 primary dimer interface [polypeptide binding]; other site 205913004026 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004027 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004028 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004029 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004030 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004031 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 205913004032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 205913004033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 205913004034 anchoring element; other site 205913004035 dimer interface [polypeptide binding]; other site 205913004036 ATP binding site [chemical binding]; other site 205913004037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 205913004038 active site 205913004039 putative metal-binding site [ion binding]; other site 205913004040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205913004041 Protein of unknown function (DUF721); Region: DUF721; cl02324 205913004042 recombination protein F; Reviewed; Region: recF; PRK00064 205913004043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004044 Walker A/P-loop; other site 205913004045 ATP binding site [chemical binding]; other site 205913004046 Q-loop/lid; other site 205913004047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004048 ABC transporter signature motif; other site 205913004049 Walker B; other site 205913004050 D-loop; other site 205913004051 H-loop/switch region; other site 205913004052 DNA polymerase III subunit beta; Validated; Region: PRK07761 205913004053 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 205913004054 putative DNA binding surface [nucleotide binding]; other site 205913004055 dimer interface [polypeptide binding]; other site 205913004056 beta-clamp/clamp loader binding surface; other site 205913004057 beta-clamp/translesion DNA polymerase binding surface; other site 205913004058 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 205913004059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913004060 Walker A motif; other site 205913004061 ATP binding site [chemical binding]; other site 205913004062 Walker B motif; other site 205913004063 arginine finger; other site 205913004064 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 205913004065 DnaA box-binding interface [nucleotide binding]; other site 205913004066 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 205913004067 Ribonuclease P; Region: Ribonuclease_P; cl00457 205913004068 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 205913004069 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 205913004070 G-X-X-G motif; other site 205913004071 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 205913004072 RxxxH motif; other site 205913004073 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 205913004074 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205913004075 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 205913004076 P-loop; other site 205913004077 Magnesium ion binding site [ion binding]; other site 205913004078 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 205913004079 Magnesium ion binding site [ion binding]; other site 205913004080 ParB-like partition proteins; Region: parB_part; TIGR00180 205913004081 ParB-like nuclease domain; Region: ParBc; cl02129 205913004082 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 205913004083 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913004084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913004085 integral membrane protein MviN; Region: mviN; TIGR01695 205913004086 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 205913004087 active site 205913004088 Ap6A binding site [chemical binding]; other site 205913004089 nudix motif; other site 205913004090 metal binding site [ion binding]; metal-binding site 205913004091 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 205913004092 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 205913004093 active site 205913004094 NTP binding site [chemical binding]; other site 205913004095 metal binding triad [ion binding]; metal-binding site 205913004096 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 205913004097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205913004098 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 205913004099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913004100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 205913004101 Domain of unknown function (DUF348); Region: DUF348; pfam03990 205913004102 G5 domain; Region: G5; pfam07501 205913004103 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205913004104 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205913004105 catalytic residue [active] 205913004106 Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227 205913004107 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205913004108 active site 205913004109 ATP binding site [chemical binding]; other site 205913004110 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913004111 substrate binding site [chemical binding]; other site 205913004112 activation loop (A-loop); other site 205913004113 Ion channel; Region: Ion_trans_2; cl11596 205913004114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 205913004115 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 205913004116 catalytic residues [active] 205913004117 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205913004118 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 205913004119 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 205913004120 Class I ribonucleotide reductase; Region: RNR_I; cd01679 205913004121 active site 205913004122 dimer interface [polypeptide binding]; other site 205913004123 catalytic residues [active] 205913004124 effector binding site; other site 205913004125 R2 peptide binding site; other site 205913004126 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 205913004127 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 205913004128 dimer interface [polypeptide binding]; other site 205913004129 putative radical transfer pathway; other site 205913004130 diiron center [ion binding]; other site 205913004131 tyrosyl radical; other site 205913004132 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205913004133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205913004134 active site 205913004135 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205913004136 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 205913004137 Walker A/P-loop; other site 205913004138 ATP binding site [chemical binding]; other site 205913004139 Q-loop/lid; other site 205913004140 ABC transporter signature motif; other site 205913004141 Walker B; other site 205913004142 D-loop; other site 205913004143 H-loop/switch region; other site 205913004144 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 205913004145 active site 205913004146 catalytic site [active] 205913004147 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 205913004148 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 205913004149 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 205913004150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913004152 putative substrate translocation pore; other site 205913004153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004154 putative substrate translocation pore; other site 205913004155 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913004156 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913004157 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 205913004158 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 205913004159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913004160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913004161 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 205913004162 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205913004163 trimer interface [polypeptide binding]; other site 205913004164 active site 205913004165 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 205913004166 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913004167 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 205913004168 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 205913004169 nucleoside/Zn binding site; other site 205913004170 dimer interface [polypeptide binding]; other site 205913004171 catalytic motif [active] 205913004172 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 205913004173 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 205913004174 catalytic site [active] 205913004175 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913004176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913004177 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205913004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913004179 dimer interface [polypeptide binding]; other site 205913004180 conserved gate region; other site 205913004181 putative PBP binding loops; other site 205913004182 ABC-ATPase subunit interface; other site 205913004183 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913004185 dimer interface [polypeptide binding]; other site 205913004186 conserved gate region; other site 205913004187 putative PBP binding loops; other site 205913004188 ABC-ATPase subunit interface; other site 205913004189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004191 DNA binding site [nucleotide binding] 205913004192 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004193 ligand binding site [chemical binding]; other site 205913004194 dimerization interface [polypeptide binding]; other site 205913004195 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004196 dimerization interface [polypeptide binding]; other site 205913004197 ligand binding site [chemical binding]; other site 205913004198 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913004199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913004200 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 205913004201 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913004202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913004203 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205913004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913004205 dimer interface [polypeptide binding]; other site 205913004206 conserved gate region; other site 205913004207 putative PBP binding loops; other site 205913004208 ABC-ATPase subunit interface; other site 205913004209 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913004211 dimer interface [polypeptide binding]; other site 205913004212 conserved gate region; other site 205913004213 putative PBP binding loops; other site 205913004214 ABC-ATPase subunit interface; other site 205913004215 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 205913004216 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913004217 Probable galactinol--sucrose galactosyltransferase; Region: PLN02684; cl14104 205913004218 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 205913004219 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913004220 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 205913004221 tetramer interface [polypeptide binding]; other site 205913004222 threonine dehydratase; Provisional; Region: PRK08198 205913004223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004224 catalytic residue [active] 205913004225 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 205913004226 SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410 205913004227 NAD+ binding site [chemical binding]; other site 205913004228 substrate binding site [chemical binding]; other site 205913004229 Zn binding site [ion binding]; other site 205913004230 Predicted membrane protein [Function unknown]; Region: COG1511 205913004231 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 205913004232 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205913004233 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 205913004234 Predicted membrane protein [Function unknown]; Region: COG1511 205913004235 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205913004236 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 205913004237 dimer interface [polypeptide binding]; other site 205913004238 FMN binding site [chemical binding]; other site 205913004239 NADPH bind site [chemical binding]; other site 205913004240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913004241 catalytic core [active] 205913004242 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913004243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004245 DNA binding site [nucleotide binding] 205913004246 domain linker motif; other site 205913004247 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004248 ligand binding site [chemical binding]; other site 205913004249 dimerization interface [polypeptide binding]; other site 205913004250 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205913004251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913004252 putative PBP binding loops; other site 205913004253 dimer interface [polypeptide binding]; other site 205913004254 ABC-ATPase subunit interface; other site 205913004255 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913004257 dimer interface [polypeptide binding]; other site 205913004258 conserved gate region; other site 205913004259 putative PBP binding loops; other site 205913004260 ABC-ATPase subunit interface; other site 205913004261 Protein of unknown function, DUF624; Region: DUF624; cl02369 205913004262 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 205913004263 active site 205913004264 Archaeal ATPase; Region: Arch_ATPase; pfam01637 205913004265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004266 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 205913004267 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 205913004268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913004269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913004270 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913004271 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205913004272 Walker A/P-loop; other site 205913004273 ATP binding site [chemical binding]; other site 205913004274 Q-loop/lid; other site 205913004275 ABC transporter signature motif; other site 205913004276 Walker B; other site 205913004277 D-loop; other site 205913004278 H-loop/switch region; other site 205913004279 hypothetical protein; Provisional; Region: PRK11281 205913004280 FtsX-like permease family; Region: FtsX; pfam02687 205913004281 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 205913004282 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913004283 Divergent AAA domain; Region: AAA_4; pfam04326 205913004284 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 205913004285 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 205913004286 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 205913004287 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 205913004288 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 205913004289 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 205913004290 active site 205913004291 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 205913004292 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 205913004293 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 205913004294 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 205913004295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004296 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913004297 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913004298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004299 Walker A/P-loop; other site 205913004300 ATP binding site [chemical binding]; other site 205913004301 Q-loop/lid; other site 205913004302 ABC transporter signature motif; other site 205913004303 Walker B; other site 205913004304 D-loop; other site 205913004305 H-loop/switch region; other site 205913004306 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913004307 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913004308 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 205913004309 Walker A/P-loop; other site 205913004310 ATP binding site [chemical binding]; other site 205913004311 Q-loop/lid; other site 205913004312 ABC transporter signature motif; other site 205913004313 Walker B; other site 205913004314 D-loop; other site 205913004315 H-loop/switch region; other site 205913004316 ApbE family; Region: ApbE; cl00643 205913004317 putative transporter; Provisional; Region: PRK11462 205913004318 Predicted methyltransferases [General function prediction only]; Region: COG0313 205913004319 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 205913004320 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 205913004321 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 205913004322 active site 205913004323 HIGH motif; other site 205913004324 KMSKS motif; other site 205913004325 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 205913004326 tRNA binding surface [nucleotide binding]; other site 205913004327 anticodon binding site; other site 205913004328 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 205913004329 trimer interface [polypeptide binding]; other site 205913004330 active site 205913004331 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 205913004332 Cupin domain; Region: Cupin_2; cl09118 205913004333 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205913004334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205913004335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004337 DNA binding site [nucleotide binding] 205913004338 domain linker motif; other site 205913004339 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004340 dimerization interface [polypeptide binding]; other site 205913004341 ligand binding site [chemical binding]; other site 205913004342 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 205913004343 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913004344 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913004345 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004346 Walker A/P-loop; other site 205913004347 ATP binding site [chemical binding]; other site 205913004348 Q-loop/lid; other site 205913004349 ABC transporter signature motif; other site 205913004350 Walker B; other site 205913004351 D-loop; other site 205913004352 H-loop/switch region; other site 205913004353 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913004354 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913004355 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 205913004356 Walker A/P-loop; other site 205913004357 ATP binding site [chemical binding]; other site 205913004358 Q-loop/lid; other site 205913004359 ABC transporter signature motif; other site 205913004360 Walker B; other site 205913004361 D-loop; other site 205913004362 H-loop/switch region; other site 205913004363 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 205913004364 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 205913004365 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 205913004366 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 205913004367 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 205913004368 substrate binding site [chemical binding]; other site 205913004369 active site 205913004370 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 205913004371 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 205913004372 substrate binding site [chemical binding]; other site 205913004373 active site 205913004374 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 205913004375 active site 205913004376 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004377 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004378 DNA binding site [nucleotide binding] 205913004379 domain linker motif; other site 205913004380 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004381 dimerization interface [polypeptide binding]; other site 205913004382 ligand binding site [chemical binding]; other site 205913004383 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913004384 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913004385 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 205913004386 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 205913004387 active site 205913004388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913004389 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913004390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913004391 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205913004392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913004393 dimer interface [polypeptide binding]; other site 205913004394 conserved gate region; other site 205913004395 putative PBP binding loops; other site 205913004396 ABC-ATPase subunit interface; other site 205913004397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913004399 dimer interface [polypeptide binding]; other site 205913004400 conserved gate region; other site 205913004401 putative PBP binding loops; other site 205913004402 ABC-ATPase subunit interface; other site 205913004403 Fic/DOC family; Region: Fic; cl00960 205913004404 Fic/DOC family; Region: Fic; cl00960 205913004405 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 205913004406 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205913004407 active site 205913004408 K+ potassium transporter; Region: K_trans; cl01227 205913004409 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 205913004410 putative active site [active] 205913004411 putative dimer interface [polypeptide binding]; other site 205913004412 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 205913004413 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913004414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004415 Walker A/P-loop; other site 205913004416 ATP binding site [chemical binding]; other site 205913004417 Q-loop/lid; other site 205913004418 ABC transporter signature motif; other site 205913004419 Walker B; other site 205913004420 D-loop; other site 205913004421 H-loop/switch region; other site 205913004422 FtsX-like permease family; Region: FtsX; pfam02687 205913004423 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 205913004424 Acyltransferase family; Region: Acyl_transf_3; pfam01757 205913004425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 205913004426 Sulfatase; Region: Sulfatase; cl10460 205913004427 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 205913004428 Ligand binding site [chemical binding]; other site 205913004429 Putative Catalytic site [active] 205913004430 DXD motif; other site 205913004431 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 205913004432 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 205913004433 NAD binding site [chemical binding]; other site 205913004434 substrate binding site [chemical binding]; other site 205913004435 homodimer interface [polypeptide binding]; other site 205913004436 active site 205913004437 Cupin domain; Region: Cupin_2; cl09118 205913004438 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 205913004439 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 205913004440 NADP binding site [chemical binding]; other site 205913004441 active site 205913004442 putative substrate binding site [chemical binding]; other site 205913004443 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 205913004444 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 205913004445 substrate binding site [chemical binding]; other site 205913004446 tetramer interface [polypeptide binding]; other site 205913004447 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205913004448 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913004449 active site 205913004450 Rhamnan synthesis protein F; Region: RgpF; cl01529 205913004451 ABC-2 type transporter; Region: ABC2_membrane; cl11417 205913004452 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 205913004453 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 205913004454 Walker A/P-loop; other site 205913004455 ATP binding site [chemical binding]; other site 205913004456 Q-loop/lid; other site 205913004457 ABC transporter signature motif; other site 205913004458 Walker B; other site 205913004459 D-loop; other site 205913004460 H-loop/switch region; other site 205913004461 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205913004462 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205913004463 Sulfatase; Region: Sulfatase; cl10460 205913004464 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 205913004465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913004466 active site 205913004467 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 205913004468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913004469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913004470 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 205913004471 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 205913004472 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 205913004473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004474 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205913004475 Bacterial transcriptional regulator; Region: IclR; pfam01614 205913004476 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 205913004477 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 205913004478 active sites [active] 205913004479 tetramer interface [polypeptide binding]; other site 205913004480 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 205913004481 Clp amino terminal domain; Region: Clp_N; pfam02861 205913004482 Clp amino terminal domain; Region: Clp_N; pfam02861 205913004483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913004484 Walker A motif; other site 205913004485 ATP binding site [chemical binding]; other site 205913004486 Walker B motif; other site 205913004487 arginine finger; other site 205913004488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913004489 Walker A motif; other site 205913004490 ATP binding site [chemical binding]; other site 205913004491 Walker B motif; other site 205913004492 arginine finger; other site 205913004493 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 205913004494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913004495 active site 205913004496 HIGH motif; other site 205913004497 nucleotide binding site [chemical binding]; other site 205913004498 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913004499 active site 205913004500 KMSKS motif; other site 205913004501 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 205913004502 active site 205913004503 catalytic site [active] 205913004504 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 205913004505 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913004506 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913004507 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 205913004508 active site 205913004509 Ap6A binding site [chemical binding]; other site 205913004510 nudix motif; other site 205913004511 metal binding site [ion binding]; metal-binding site 205913004512 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913004513 catalytic core [active] 205913004514 polyphosphate kinase; Provisional; Region: PRK05443 205913004515 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 205913004516 putative domain interface [polypeptide binding]; other site 205913004517 putative active site [active] 205913004518 catalytic site [active] 205913004519 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 205913004520 putative domain interface [polypeptide binding]; other site 205913004521 putative active site [active] 205913004522 catalytic site [active] 205913004523 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 205913004524 putative active site [active] 205913004525 putative metal binding site [ion binding]; other site 205913004526 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 205913004527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004528 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205913004529 Bacterial transcriptional regulator; Region: IclR; pfam01614 205913004530 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 205913004531 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 205913004532 substrate binding site [chemical binding]; other site 205913004533 ligand binding site [chemical binding]; other site 205913004534 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 205913004535 substrate binding site [chemical binding]; other site 205913004536 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP...; Region: DHOD_DHPD_FMN; cd02810 205913004537 active site 205913004538 FMN binding site [chemical binding]; other site 205913004539 substrate binding site [chemical binding]; other site 205913004540 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 205913004541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913004542 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205913004543 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 205913004544 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 205913004545 hinge; other site 205913004546 active site 205913004547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913004548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004549 homodimer interface [polypeptide binding]; other site 205913004550 catalytic residue [active] 205913004551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205913004552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004553 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 205913004554 putative dimerization interface [polypeptide binding]; other site 205913004555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913004557 putative substrate translocation pore; other site 205913004558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913004559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913004560 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 205913004561 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 205913004562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913004563 active site 205913004564 HIGH motif; other site 205913004565 nucleotide binding site [chemical binding]; other site 205913004566 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 205913004567 KMSK motif region; other site 205913004568 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 205913004569 tRNA binding surface [nucleotide binding]; other site 205913004570 anticodon binding site; other site 205913004571 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 205913004572 catalytic residue [active] 205913004573 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 205913004574 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205913004575 homoserine dehydrogenase; Provisional; Region: PRK06349 205913004576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913004577 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 205913004578 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 205913004579 homoserine kinase; Provisional; Region: PRK01212 205913004580 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 205913004581 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 205913004582 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 205913004583 dimer interface [polypeptide binding]; other site 205913004584 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 205913004585 nudix motif; other site 205913004586 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 205913004587 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913004588 Walker A/P-loop; other site 205913004589 ATP binding site [chemical binding]; other site 205913004590 Q-loop/lid; other site 205913004591 ABC transporter signature motif; other site 205913004592 Walker B; other site 205913004593 D-loop; other site 205913004594 H-loop/switch region; other site 205913004595 Membrane transport protein; Region: Mem_trans; cl09117 205913004596 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 205913004597 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 205913004598 metal binding site [ion binding]; metal-binding site 205913004599 putative dimer interface [polypeptide binding]; other site 205913004600 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 205913004601 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 205913004602 homodimer interface [polypeptide binding]; other site 205913004603 oligonucleotide binding site [chemical binding]; other site 205913004604 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 205913004605 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 205913004606 GTPase CgtA; Reviewed; Region: obgE; PRK12296 205913004607 GTP1/OBG; Region: GTP1_OBG; pfam01018 205913004608 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 205913004609 G1 box; other site 205913004610 GTP/Mg2+ binding site [chemical binding]; other site 205913004611 Switch I region; other site 205913004612 G2 box; other site 205913004613 G3 box; other site 205913004614 Switch II region; other site 205913004615 G4 box; other site 205913004616 G5 box; other site 205913004617 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 205913004618 gamma-glutamyl kinase; Provisional; Region: PRK05429 205913004619 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 205913004620 nucleotide binding site [chemical binding]; other site 205913004621 homotetrameric interface [polypeptide binding]; other site 205913004622 putative phosphate binding site [ion binding]; other site 205913004623 putative allosteric binding site; other site 205913004624 PUA domain; Region: PUA; cl00607 205913004625 aspartate aminotransferase; Provisional; Region: PRK08361 205913004626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913004627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004628 homodimer interface [polypeptide binding]; other site 205913004629 catalytic residue [active] 205913004630 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 205913004631 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 205913004632 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 205913004633 putative homodimer interface [polypeptide binding]; other site 205913004634 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 205913004635 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 205913004636 23S rRNA interface [nucleotide binding]; other site 205913004637 L7/L12 interface [polypeptide binding]; other site 205913004638 putative thiostrepton binding site; other site 205913004639 L25 interface [polypeptide binding]; other site 205913004640 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 205913004641 mRNA/rRNA interface [nucleotide binding]; other site 205913004642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004643 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205913004644 Bacterial transcriptional regulator; Region: IclR; pfam01614 205913004645 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205913004646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004647 Bacterial transcriptional regulator; Region: IclR; pfam01614 205913004648 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 205913004649 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 205913004650 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 205913004651 BioY family; Region: BioY; cl00560 205913004652 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 205913004653 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205913004654 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 205913004655 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 205913004656 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 205913004657 carboxyltransferase (CT) interaction site; other site 205913004658 biotinylation site [posttranslational modification]; other site 205913004659 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 205913004660 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 205913004661 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 205913004662 Acyl transferase domain; Region: Acyl_transf_1; cl08282 205913004663 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 205913004664 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 205913004665 FMN binding site [chemical binding]; other site 205913004666 substrate binding site [chemical binding]; other site 205913004667 putative catalytic residue [active] 205913004668 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 205913004669 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 205913004670 putative active site [active] 205913004671 putative catalytic site [active] 205913004672 Acyl transferase domain; Region: Acyl_transf_1; cl08282 205913004673 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 205913004674 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 205913004675 putative NAD(P) binding site [chemical binding]; other site 205913004676 active site 205913004677 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 205913004678 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 205913004679 active site 205913004680 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 205913004681 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205913004682 metal ion-dependent adhesion site (MIDAS); other site 205913004683 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 205913004684 putative Ca2+ binding sites [ion binding]; other site 205913004685 Integrase core domain; Region: rve; cl01316 205913004686 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 205913004687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913004688 Integrase core domain; Region: rve; cl01316 205913004689 transposase; Provisional; Region: PRK06526 205913004690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913004691 Walker A motif; other site 205913004692 ATP binding site [chemical binding]; other site 205913004693 Walker B motif; other site 205913004694 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913004695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913004696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913004697 active site 205913004698 phosphorylation site [posttranslational modification] 205913004699 intermolecular recognition site; other site 205913004700 dimerization interface [polypeptide binding]; other site 205913004701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 205913004702 DNA binding residues [nucleotide binding] 205913004703 dimerization interface [polypeptide binding]; other site 205913004704 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 205913004705 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205913004706 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 205913004707 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 205913004708 active site 205913004709 zinc binding site [ion binding]; other site 205913004710 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 205913004711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004712 Walker A/P-loop; other site 205913004713 ATP binding site [chemical binding]; other site 205913004714 Q-loop/lid; other site 205913004715 ABC transporter signature motif; other site 205913004716 Walker B; other site 205913004717 D-loop; other site 205913004718 H-loop/switch region; other site 205913004719 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 205913004720 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 205913004721 putative active site [active] 205913004722 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913004723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004724 Walker A/P-loop; other site 205913004725 ATP binding site [chemical binding]; other site 205913004726 Q-loop/lid; other site 205913004727 ABC transporter signature motif; other site 205913004728 Walker B; other site 205913004729 D-loop; other site 205913004730 H-loop/switch region; other site 205913004731 Integrase core domain; Region: rve; cl01316 205913004732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004733 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913004734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913004735 Integrase core domain; Region: rve; cl01316 205913004736 transposase; Provisional; Region: PRK06526 205913004737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913004738 Walker A motif; other site 205913004739 ATP binding site [chemical binding]; other site 205913004740 Walker B motif; other site 205913004741 Integrase core domain; Region: rve; cl01316 205913004742 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 205913004743 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 205913004744 substrate binding site [chemical binding]; other site 205913004745 active site 205913004746 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 205913004747 metal binding site [ion binding]; metal-binding site 205913004748 ligand binding site [chemical binding]; other site 205913004749 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 205913004750 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 205913004751 active site 205913004752 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 205913004753 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 205913004754 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 205913004755 16S/18S rRNA binding site [nucleotide binding]; other site 205913004756 S13e-L30e interaction site [polypeptide binding]; other site 205913004757 25S rRNA binding site [nucleotide binding]; other site 205913004758 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 205913004759 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 205913004760 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 205913004761 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 205913004762 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 205913004763 putative nucleic acid binding region [nucleotide binding]; other site 205913004764 G-X-X-G motif; other site 205913004765 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 205913004766 RNA binding site [nucleotide binding]; other site 205913004767 domain interface; other site 205913004768 Sulfate transporter family; Region: Sulfate_transp; cl00967 205913004769 Permease family; Region: Xan_ur_permease; pfam00860 205913004770 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 205913004771 23S rRNA interface [nucleotide binding]; other site 205913004772 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 205913004773 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 205913004774 peripheral dimer interface [polypeptide binding]; other site 205913004775 core dimer interface [polypeptide binding]; other site 205913004776 L10 interface [polypeptide binding]; other site 205913004777 L11 interface [polypeptide binding]; other site 205913004778 putative EF-Tu interaction site [polypeptide binding]; other site 205913004779 putative EF-G interaction site [polypeptide binding]; other site 205913004780 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913004781 phosphopeptide binding site; other site 205913004782 SAF domain; Region: SAF; cl00555 205913004783 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 205913004784 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 205913004785 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205913004786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205913004787 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 205913004788 oligomerisation interface [polypeptide binding]; other site 205913004789 mobile loop; other site 205913004790 roof hairpin; other site 205913004791 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913004792 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913004793 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 205913004794 FAD binding domain; Region: FAD_binding_4; pfam01565 205913004795 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 205913004796 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 205913004797 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 205913004798 Ferredoxin [Energy production and conversion]; Region: COG1146 205913004799 4Fe-4S binding domain; Region: Fer4; cl02805 205913004800 aspartate aminotransferase; Provisional; Region: PRK07681 205913004801 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913004802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004803 homodimer interface [polypeptide binding]; other site 205913004804 catalytic residue [active] 205913004805 DNA polymerase IV; Validated; Region: PRK03858 205913004806 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 205913004807 active site 205913004808 DNA binding site [nucleotide binding] 205913004809 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 205913004810 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 205913004811 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 205913004812 putative active site [active] 205913004813 putative metal binding site [ion binding]; other site 205913004814 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205913004815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913004816 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 205913004817 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 205913004818 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 205913004819 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 205913004820 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 205913004821 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 205913004822 23S rRNA interface [nucleotide binding]; other site 205913004823 L3 interface [polypeptide binding]; other site 205913004824 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 205913004825 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 205913004826 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 205913004827 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 205913004828 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 205913004829 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205913004830 putative NAD(P) binding site [chemical binding]; other site 205913004831 catalytic Zn binding site [ion binding]; other site 205913004832 polyol permease family; Region: 2A0118; TIGR00897 205913004833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004834 putative substrate translocation pore; other site 205913004835 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 205913004836 active site 205913004837 metal binding site [ion binding]; metal-binding site 205913004838 polyol permease family; Region: 2A0118; TIGR00897 205913004839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004840 putative substrate translocation pore; other site 205913004841 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205913004842 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 205913004843 inhibitor binding site; inhibition site 205913004844 catalytic Zn binding site [ion binding]; other site 205913004845 structural Zn binding site [ion binding]; other site 205913004846 NADP binding site [chemical binding]; other site 205913004847 tetramer interface [polypeptide binding]; other site 205913004848 Helix-turn-helix domain; Region: HTH_18; pfam12833 205913004849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205913004850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004851 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913004852 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913004853 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 205913004854 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 205913004855 putative catalytic cysteine [active] 205913004856 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 205913004857 putative active site [active] 205913004858 metal binding site [ion binding]; metal-binding site 205913004859 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 205913004860 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 205913004861 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 205913004862 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 205913004863 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 205913004864 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 205913004865 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 205913004866 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 205913004867 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 205913004868 putative translocon binding site; other site 205913004869 protein-rRNA interface [nucleotide binding]; other site 205913004870 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 205913004871 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 205913004872 G-X-X-G motif; other site 205913004873 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 205913004874 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 205913004875 23S rRNA interface [nucleotide binding]; other site 205913004876 5S rRNA interface [nucleotide binding]; other site 205913004877 putative antibiotic binding site [chemical binding]; other site 205913004878 L25 interface [polypeptide binding]; other site 205913004879 L27 interface [polypeptide binding]; other site 205913004880 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 205913004881 23S rRNA interface [nucleotide binding]; other site 205913004882 putative translocon interaction site; other site 205913004883 signal recognition particle (SRP54) interaction site; other site 205913004884 L23 interface [polypeptide binding]; other site 205913004885 trigger factor interaction site; other site 205913004886 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 205913004887 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 205913004888 KOW motif; Region: KOW; cl00354 205913004889 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 205913004890 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 205913004891 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 205913004892 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 205913004893 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 205913004894 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 205913004895 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205913004896 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205913004897 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 205913004898 23S rRNA interface [nucleotide binding]; other site 205913004899 L21e interface [polypeptide binding]; other site 205913004900 5S rRNA interface [nucleotide binding]; other site 205913004901 L27 interface [polypeptide binding]; other site 205913004902 L5 interface [polypeptide binding]; other site 205913004903 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 205913004904 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 205913004905 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 205913004906 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 205913004907 23S rRNA binding site [nucleotide binding]; other site 205913004908 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 205913004909 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 205913004910 SecY translocase; Region: SecY; pfam00344 205913004911 adenylate kinase; Reviewed; Region: adk; PRK00279 205913004912 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 205913004913 AMP-binding site [chemical binding]; other site 205913004914 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 205913004915 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 205913004916 rRNA binding site [nucleotide binding]; other site 205913004917 predicted 30S ribosome binding site; other site 205913004918 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 205913004919 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 205913004920 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 205913004921 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 205913004922 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 205913004923 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 205913004924 alphaNTD homodimer interface [polypeptide binding]; other site 205913004925 alphaNTD - beta interaction site [polypeptide binding]; other site 205913004926 alphaNTD - beta' interaction site [polypeptide binding]; other site 205913004927 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 205913004928 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 205913004929 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 205913004930 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 205913004931 dimerization interface 3.5A [polypeptide binding]; other site 205913004932 active site 205913004933 Uncharacterized conserved protein [Function unknown]; Region: COG2308 205913004934 Domain of unknown function (DUF404); Region: DUF404; pfam04169 205913004935 Domain of unknown function (DUF407); Region: DUF407; pfam04174 205913004936 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 205913004937 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 205913004938 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 205913004939 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 205913004940 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 205913004941 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004942 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004943 DNA binding site [nucleotide binding] 205913004944 domain linker motif; other site 205913004945 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004946 dimerization interface [polypeptide binding]; other site 205913004947 ligand binding site [chemical binding]; other site 205913004948 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 205913004949 NusA N-terminal domain; Region: NusA_N; pfam08529 205913004950 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 205913004951 RNA binding site [nucleotide binding]; other site 205913004952 homodimer interface [polypeptide binding]; other site 205913004953 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 205913004954 G-X-X-G motif; other site 205913004955 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205913004956 translation initiation factor IF-2; Region: IF-2; TIGR00487 205913004957 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205913004958 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 205913004959 G1 box; other site 205913004960 putative GEF interaction site [polypeptide binding]; other site 205913004961 GTP/Mg2+ binding site [chemical binding]; other site 205913004962 Switch I region; other site 205913004963 G2 box; other site 205913004964 G3 box; other site 205913004965 Switch II region; other site 205913004966 G4 box; other site 205913004967 G5 box; other site 205913004968 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 205913004969 Translation-initiation factor 2; Region: IF-2; pfam11987 205913004970 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 205913004971 Ribosome-binding factor A; Region: RBFA; cl00542 205913004972 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 205913004973 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 205913004974 RNA binding site [nucleotide binding]; other site 205913004975 active site 205913004976 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 205913004977 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 205913004978 active site 205913004979 Riboflavin kinase; Region: Flavokinase; pfam01687 205913004980 DNA repair protein RadA; Provisional; Region: PRK11823 205913004981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913004982 Walker A motif; other site 205913004983 ATP binding site [chemical binding]; other site 205913004984 Walker B motif; other site 205913004985 similar to hypothetical protein 205913004986 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 205913004987 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913004988 active site 205913004989 dimer interface [polypeptide binding]; other site 205913004990 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 205913004991 RNA/DNA hybrid binding site [nucleotide binding]; other site 205913004992 active site 205913004993 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 205913004994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 205913004995 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 205913004996 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205913004997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913004998 Rrf2 family protein; Region: rrf2_super; TIGR00738 205913004999 phosphoglucomutase; Validated; Region: PRK07564 205913005000 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 205913005001 active site 205913005002 substrate binding site [chemical binding]; other site 205913005003 metal binding site [ion binding]; metal-binding site 205913005004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005005 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 205913005006 putative substrate translocation pore; other site 205913005007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005008 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 205913005009 active site turn [active] 205913005010 phosphorylation site [posttranslational modification] 205913005011 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 205913005012 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 205913005013 HPr interaction site; other site 205913005014 glycerol kinase (GK) interaction site [polypeptide binding]; other site 205913005015 active site 205913005016 phosphorylation site [posttranslational modification] 205913005017 transcriptional antiterminator BglG; Provisional; Region: PRK09772 205913005018 CAT RNA binding domain; Region: CAT_RBD; pfam03123 205913005019 PRD domain; Region: PRD; pfam00874 205913005020 PRD domain; Region: PRD; pfam00874 205913005021 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 205913005022 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 205913005023 seryl-tRNA synthetase; Provisional; Region: PRK05431 205913005024 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 205913005025 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 205913005026 dimer interface [polypeptide binding]; other site 205913005027 active site 205913005028 motif 1; other site 205913005029 motif 2; other site 205913005030 motif 3; other site 205913005031 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913005032 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913005033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 205913005034 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205913005035 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913005036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913005037 dimer interface [polypeptide binding]; other site 205913005038 conserved gate region; other site 205913005039 putative PBP binding loops; other site 205913005040 ABC-ATPase subunit interface; other site 205913005041 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 205913005042 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 205913005043 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205913005044 active site 205913005045 substrate binding site [chemical binding]; other site 205913005046 ATP binding site [chemical binding]; other site 205913005047 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 205913005048 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 205913005049 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 205913005050 UDP-glucose 4-epimerase; Region: PLN02240 205913005051 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 205913005052 NAD binding site [chemical binding]; other site 205913005053 homodimer interface [polypeptide binding]; other site 205913005054 active site 205913005055 substrate binding site [chemical binding]; other site 205913005056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913005057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 205913005058 active site 205913005059 phosphorylation site [posttranslational modification] 205913005060 intermolecular recognition site; other site 205913005061 dimerization interface [polypeptide binding]; other site 205913005062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 205913005063 DNA binding residues [nucleotide binding] 205913005064 dimerization interface [polypeptide binding]; other site 205913005065 PspC domain; Region: PspC; cl00864 205913005066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205913005067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 205913005068 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 205913005069 MFS transport protein AraJ; Provisional; Region: PRK10091 205913005070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005071 putative substrate translocation pore; other site 205913005072 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 205913005073 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 205913005074 dimer interface [polypeptide binding]; other site 205913005075 putative anticodon binding site; other site 205913005076 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913005077 motif 1; other site 205913005078 dimer interface [polypeptide binding]; other site 205913005079 active site 205913005080 motif 2; other site 205913005081 motif 3; other site 205913005082 UbiA prenyltransferase family; Region: UbiA; cl00337 205913005083 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 205913005084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913005085 catalytic core [active] 205913005086 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 205913005087 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 205913005088 PhoU domain; Region: PhoU; pfam01895 205913005089 PhoU domain; Region: PhoU; pfam01895 205913005090 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205913005091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913005092 ATP binding site [chemical binding]; other site 205913005093 Mg2+ binding site [ion binding]; other site 205913005094 G-X-G motif; other site 205913005095 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913005096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913005097 catalytic residue [active] 205913005098 NlpC/P60 family; Region: NLPC_P60; cl11438 205913005099 NlpC/P60 family; Region: NLPC_P60; cl11438 205913005100 NlpC/P60 family; Region: NLPC_P60; cl11438 205913005101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205913005102 Ligand Binding Site [chemical binding]; other site 205913005103 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205913005104 Ligand Binding Site [chemical binding]; other site 205913005105 OsmC-like protein; Region: OsmC; cl00767 205913005106 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 205913005107 dimerization interface [polypeptide binding]; other site 205913005108 active site 205913005109 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 205913005110 folate binding site [chemical binding]; other site 205913005111 NADP+ binding site [chemical binding]; other site 205913005112 Low molecular weight phosphatase family; Region: LMWPc; cd00115 205913005113 Active site [active] 205913005114 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 205913005115 AzlC protein; Region: AzlC; cl00570 205913005116 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913005117 DNA binding site [nucleotide binding] 205913005118 Int/Topo IB signature motif; other site 205913005119 active site 205913005120 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913005121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913005122 Walker A motif; other site 205913005123 ATP binding site [chemical binding]; other site 205913005124 Walker B motif; other site 205913005125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913005126 Integrase core domain; Region: rve; cl01316 205913005127 MULE transposase domain; Region: MULE; pfam10551 205913005128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913005129 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913005130 Integrase core domain; Region: rve; cl01316 205913005131 putative transposase OrfB; Reviewed; Region: PHA02517 205913005132 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913005133 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913005134 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes...; Region: INT_pAE1; cd01188 205913005135 Int/Topo IB signature motif; other site 205913005136 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 205913005137 Phage integrase family; Region: Phage_integrase; pfam00589 205913005138 Int/Topo IB signature motif; other site 205913005139 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913005140 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913005141 DNA binding site [nucleotide binding] 205913005142 Int/Topo IB signature motif; other site 205913005143 active site 205913005144 putative transposase OrfB; Reviewed; Region: PHA02517 205913005145 Integrase core domain; Region: rve; cl01316 205913005146 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 205913005147 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 205913005148 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 205913005149 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205913005150 catalytic residue [active] 205913005151 Surface antigen [General function prediction only]; Region: COG3942 205913005152 NlpC/P60 family; Region: NLPC_P60; cl11438 205913005153 AAA-like domain; Region: AAA_10; pfam12846 205913005154 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 205913005155 AAA-like domain; Region: AAA_10; pfam12846 205913005156 Domain of unknown function DUF87; Region: DUF87; pfam01935 205913005157 PrgI family protein; Region: PrgI; pfam12666 205913005158 Transposase, Mutator family; Region: Transposase_mut; pfam00872 205913005159 MULE transposase domain; Region: MULE; pfam10551 205913005160 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913005161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 205913005162 P-loop; other site 205913005163 Magnesium ion binding site [ion binding]; other site 205913005164 hypothetical protein; Region: PHA01623 205913005165 Transcription factor WhiB; Region: Whib; pfam02467 205913005166 BetR domain; Region: BetR; pfam08667 205913005167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913005168 sequence-specific DNA binding site [nucleotide binding]; other site 205913005169 salt bridge; other site 205913005170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 205913005171 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 205913005172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913005173 NAD(P) binding site [chemical binding]; other site 205913005174 active site 205913005175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005176 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913005177 putative substrate translocation pore; other site 205913005178 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 205913005179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 205913005180 S-adenosylmethionine binding site [chemical binding]; other site 205913005181 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 205913005182 lactaldehyde reductase; Region: lactal_redase; TIGR02638 205913005183 dimer interface [polypeptide binding]; other site 205913005184 active site 205913005185 metal binding site [ion binding]; metal-binding site 205913005186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913005187 active site 205913005188 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 205913005189 Domain of unknown function DUF20; Region: UPF0118; cl00465 205913005190 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205913005191 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 205913005192 DXD motif; other site 205913005193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205913005194 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 205913005195 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 205913005196 Walker A/P-loop; other site 205913005197 ATP binding site [chemical binding]; other site 205913005198 Q-loop/lid; other site 205913005199 ABC transporter signature motif; other site 205913005200 Walker B; other site 205913005201 D-loop; other site 205913005202 H-loop/switch region; other site 205913005203 Beta-lactamase; Region: Beta-lactamase; cl01009 205913005204 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 205913005205 Ligand Binding Site [chemical binding]; other site 205913005206 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 205913005207 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 205913005208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913005209 Walker A motif; other site 205913005210 ATP binding site [chemical binding]; other site 205913005211 Walker B motif; other site 205913005212 arginine finger; other site 205913005213 Peptidase family M41; Region: Peptidase_M41; pfam01434 205913005214 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 205913005215 homodecamer interface [polypeptide binding]; other site 205913005216 GTP cyclohydrolase I; Provisional; Region: PLN03044 205913005217 active site 205913005218 putative catalytic site residues [active] 205913005219 zinc binding site [ion binding]; other site 205913005220 GTP-CH-I/GFRP interaction surface; other site 205913005221 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 205913005222 dihydropteroate synthase; Region: DHPS; TIGR01496 205913005223 substrate binding pocket [chemical binding]; other site 205913005224 dimer interface [polypeptide binding]; other site 205913005225 inhibitor binding site; inhibition site 205913005226 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 205913005227 homooctamer interface [polypeptide binding]; other site 205913005228 active site 205913005229 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 205913005230 catalytic center binding site [active] 205913005231 ATP binding site [chemical binding]; other site 205913005232 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 205913005233 catalytic center binding site [active] 205913005234 ATP binding site [chemical binding]; other site 205913005235 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 205913005236 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 205913005237 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 205913005238 active site 205913005239 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 205913005240 catalytic triad [active] 205913005241 dimer interface [polypeptide binding]; other site 205913005242 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 205913005243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913005244 Walker A/P-loop; other site 205913005245 ATP binding site [chemical binding]; other site 205913005246 Q-loop/lid; other site 205913005247 ABC transporter signature motif; other site 205913005248 Walker B; other site 205913005249 D-loop; other site 205913005250 H-loop/switch region; other site 205913005251 ABC transporter; Region: ABC_tran_2; pfam12848 205913005252 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 205913005253 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 205913005254 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913005255 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 205913005256 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 205913005257 Walker A/P-loop; other site 205913005258 ATP binding site [chemical binding]; other site 205913005259 Q-loop/lid; other site 205913005260 ABC transporter signature motif; other site 205913005261 Walker B; other site 205913005262 D-loop; other site 205913005263 H-loop/switch region; other site 205913005264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913005265 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913005266 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913005267 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 205913005268 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 205913005269 putative ligand binding site [chemical binding]; other site 205913005270 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 205913005271 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 205913005272 Walker A/P-loop; other site 205913005273 ATP binding site [chemical binding]; other site 205913005274 Q-loop/lid; other site 205913005275 ABC transporter signature motif; other site 205913005276 Walker B; other site 205913005277 D-loop; other site 205913005278 H-loop/switch region; other site 205913005279 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 205913005280 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205913005281 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205913005282 TM-ABC transporter signature motif; other site 205913005283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913005284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005285 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 205913005286 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913005287 active site 205913005288 catalytic tetrad [active] 205913005289 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 205913005290 active site 205913005291 catalytic residues [active] 205913005292 metal binding site [ion binding]; metal-binding site 205913005293 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205913005294 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205913005295 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 205913005296 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 205913005297 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 205913005298 dimer interface [polypeptide binding]; other site 205913005299 active site 205913005300 metal binding site [ion binding]; metal-binding site 205913005301 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913005302 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913005303 DNA binding site [nucleotide binding] 205913005304 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 205913005305 putative dimerization interface [polypeptide binding]; other site 205913005306 putative ligand binding site [chemical binding]; other site 205913005307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913005308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913005309 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205913005310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913005311 dimer interface [polypeptide binding]; other site 205913005312 conserved gate region; other site 205913005313 putative PBP binding loops; other site 205913005314 ABC-ATPase subunit interface; other site 205913005315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913005316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 205913005317 dimer interface [polypeptide binding]; other site 205913005318 conserved gate region; other site 205913005319 putative PBP binding loops; other site 205913005320 ABC-ATPase subunit interface; other site 205913005321 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 205913005322 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 205913005323 inhibitor binding site; inhibition site 205913005324 active site 205913005325 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 205913005326 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 205913005327 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 205913005328 active site 205913005329 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 205913005330 trimer interface [polypeptide binding]; other site 205913005331 active site 205913005332 substrate binding site [chemical binding]; other site 205913005333 CoA binding site [chemical binding]; other site 205913005334 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913005335 D-xylulose kinase; Region: XylB; TIGR01312 205913005336 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 205913005337 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913005338 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 205913005339 peptide chain release factor 1; Validated; Region: prfA; PRK00591 205913005340 RF-1 domain; Region: RF-1; cl02875 205913005341 RF-1 domain; Region: RF-1; cl02875 205913005342 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 205913005343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 205913005344 S-adenosylmethionine binding site [chemical binding]; other site 205913005345 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 205913005346 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 205913005347 putative ligand binding site [chemical binding]; other site 205913005348 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205913005349 TM-ABC transporter signature motif; other site 205913005350 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205913005351 TM-ABC transporter signature motif; other site 205913005352 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 205913005353 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 205913005354 Walker A/P-loop; other site 205913005355 ATP binding site [chemical binding]; other site 205913005356 Q-loop/lid; other site 205913005357 ABC transporter signature motif; other site 205913005358 Walker B; other site 205913005359 D-loop; other site 205913005360 H-loop/switch region; other site 205913005361 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 205913005362 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 205913005363 Walker A/P-loop; other site 205913005364 ATP binding site [chemical binding]; other site 205913005365 Q-loop/lid; other site 205913005366 ABC transporter signature motif; other site 205913005367 Walker B; other site 205913005368 D-loop; other site 205913005369 H-loop/switch region; other site 205913005370 maltose O-acetyltransferase; Provisional; Region: PRK10092 205913005371 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 205913005372 active site 205913005373 substrate binding site [chemical binding]; other site 205913005374 trimer interface [polypeptide binding]; other site 205913005375 CoA binding site [chemical binding]; other site 205913005376 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 205913005377 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 205913005378 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 205913005379 Mg++ binding site [ion binding]; other site 205913005380 putative catalytic motif [active] 205913005381 substrate binding site [chemical binding]; other site 205913005382 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 205913005383 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 205913005384 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 205913005385 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 205913005386 active site 205913005387 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 205913005388 putative active site [active] 205913005389 putative substrate binding site [chemical binding]; other site 205913005390 catalytic site [active] 205913005391 dimer interface [polypeptide binding]; other site 205913005392 PIF1-like helicase; Region: PIF1; pfam05970 205913005393 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 205913005394 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 205913005395 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 205913005396 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 205913005397 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 205913005398 prolyl-tRNA synthetase; Provisional; Region: PRK09194 205913005399 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 205913005400 dimer interface [polypeptide binding]; other site 205913005401 motif 1; other site 205913005402 active site 205913005403 motif 2; other site 205913005404 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 205913005405 putative deacylase active site [active] 205913005406 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913005407 active site 205913005408 motif 3; other site 205913005409 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 205913005410 anticodon binding site; other site 205913005411 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205913005412 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913005413 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 205913005414 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 205913005415 active site 205913005416 Zn binding site [ion binding]; other site 205913005417 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 205913005418 methionine aminopeptidase; Reviewed; Region: PRK07281 205913005419 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 205913005420 active site 205913005421 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 205913005422 Citrate synthase; Region: Citrate_synt; pfam00285 205913005423 oxalacetate binding site [chemical binding]; other site 205913005424 citrylCoA binding site [chemical binding]; other site 205913005425 coenzyme A binding site [chemical binding]; other site 205913005426 catalytic triad [active] 205913005427 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 205913005428 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 205913005429 putative trimer interface [polypeptide binding]; other site 205913005430 putative CoA binding site [chemical binding]; other site 205913005431 Predicted transcriptional regulator [Transcription]; Region: COG2378 205913005432 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 205913005433 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 205913005434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913005435 ATP binding site [chemical binding]; other site 205913005436 putative Mg++ binding site [ion binding]; other site 205913005437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913005438 nucleotide binding region [chemical binding]; other site 205913005439 ATP-binding site [chemical binding]; other site 205913005440 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205913005441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913005442 Coenzyme A binding pocket [chemical binding]; other site 205913005443 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 205913005444 additional DNA contacts [nucleotide binding]; other site 205913005445 mismatch recognition site; other site 205913005446 active site 205913005447 zinc binding site [ion binding]; other site 205913005448 DNA intercalation site [nucleotide binding]; other site 205913005449 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205913005450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913005451 aspartate aminotransferase; Provisional; Region: PRK08361 205913005452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913005453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913005454 homodimer interface [polypeptide binding]; other site 205913005455 catalytic residue [active] 205913005456 exopolyphosphatase; Region: exo_poly_only; TIGR03706 205913005457 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 205913005458 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205913005459 putative catalytic site [active] 205913005460 putative metal binding site [ion binding]; other site 205913005461 putative phosphate binding site [ion binding]; other site 205913005462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 205913005463 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 205913005464 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 205913005465 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 205913005466 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913005467 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913005468 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 205913005469 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 205913005470 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 205913005471 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 205913005472 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 205913005473 generic binding surface II; other site 205913005474 generic binding surface I; other site 205913005475 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 205913005476 ATP cone domain; Region: ATP-cone; pfam03477 205913005477 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 205913005478 Class III ribonucleotide reductase; Region: RNR_III; cd01675 205913005479 active site 205913005480 Zn binding site [ion binding]; other site 205913005481 glycine loop; other site 205913005482 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 205913005483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 205913005484 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913005485 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 205913005486 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 205913005487 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 205913005488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 205913005489 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 205913005490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913005491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913005492 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 205913005493 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205913005494 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 205913005495 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 205913005496 active site 205913005497 NTP binding site [chemical binding]; other site 205913005498 metal binding triad [ion binding]; metal-binding site 205913005499 antibiotic binding site [chemical binding]; other site 205913005500 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 205913005501 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 205913005502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913005503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913005504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913005506 putative substrate translocation pore; other site 205913005507 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 205913005508 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 205913005509 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 205913005510 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913005511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913005512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913005513 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205913005514 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 205913005515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 205913005516 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913005517 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913005518 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913005519 Walker A/P-loop; other site 205913005520 ATP binding site [chemical binding]; other site 205913005521 Q-loop/lid; other site 205913005522 ABC transporter signature motif; other site 205913005523 Walker B; other site 205913005524 D-loop; other site 205913005525 H-loop/switch region; other site 205913005526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913005527 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 205913005528 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 205913005529 Walker A/P-loop; other site 205913005530 ATP binding site [chemical binding]; other site 205913005531 Q-loop/lid; other site 205913005532 ABC transporter signature motif; other site 205913005533 Walker B; other site 205913005534 D-loop; other site 205913005535 H-loop/switch region; other site 205913005536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913005537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913005538 DNA binding site [nucleotide binding] 205913005539 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 205913005540 putative dimerization interface [polypeptide binding]; other site 205913005541 putative ligand binding site [chemical binding]; other site 205913005542 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 205913005543 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 205913005544 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 205913005545 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913005546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913005547 homodimer interface [polypeptide binding]; other site 205913005548 catalytic residue [active] 205913005549 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 205913005550 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 205913005551 HIGH motif; other site 205913005552 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 205913005553 active site 205913005554 KMSKS motif; other site 205913005555 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 205913005556 tRNA binding surface [nucleotide binding]; other site 205913005557 anticodon binding site; other site 205913005558 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 205913005559 Transposase, Mutator family; Region: Transposase_mut; pfam00872 205913005560 MULE transposase domain; Region: MULE; pfam10551 205913005561 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 205913005562 Phage integrase family; Region: Phage_integrase; pfam00589 205913005563 Int/Topo IB signature motif; other site 205913005564 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 205913005565 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 205913005566 Restriction endonuclease; Region: Mrr_cat; cl00747 205913005567 HsdM N-terminal domain; Region: HsdM_N; pfam12161 205913005568 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 205913005569 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 205913005570 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 205913005571 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 205913005572 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913005573 Divergent AAA domain; Region: AAA_4; pfam04326 205913005574 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 205913005575 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 205913005576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913005577 ATP binding site [chemical binding]; other site 205913005578 putative Mg++ binding site [ion binding]; other site 205913005579 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 205913005580 S-adenosylmethionine synthetase; Validated; Region: PRK05250 205913005581 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 205913005582 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 205913005583 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 205913005584 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 205913005585 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 205913005586 Dehydratase family; Region: ILVD_EDD; cl00340 205913005587 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 205913005588 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 205913005589 putative active site [active] 205913005590 substrate binding site [chemical binding]; other site 205913005591 putative cosubstrate binding site; other site 205913005592 catalytic site [active] 205913005593 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 205913005594 substrate binding site [chemical binding]; other site 205913005595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 205913005596 primosome assembly protein PriA; Provisional; Region: PRK14873 205913005597 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 205913005598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 205913005599 motif II; other site 205913005600 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205913005601 proteasome ATPase; Region: pup_AAA; TIGR03689 205913005602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 205913005603 Walker A motif; other site 205913005604 ATP binding site [chemical binding]; other site 205913005605 Walker B motif; other site 205913005606 arginine finger; other site 205913005607 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 205913005608 Pup-ligase protein; Region: Pup_ligase; pfam03136 205913005609 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 205913005610 active site 205913005611 Pup-like protein; Region: Pup; cl05289 205913005612 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 205913005613 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 205913005614 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 205913005615 IHF dimer interface [polypeptide binding]; other site 205913005616 IHF - DNA interface [nucleotide binding]; other site 205913005617 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 205913005618 adenylosuccinate lyase; Provisional; Region: PRK09285 205913005619 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 205913005620 tetramer interface [polypeptide binding]; other site 205913005621 active site 205913005622 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 205913005623 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 205913005624 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205913005625 metal ion-dependent adhesion site (MIDAS); other site 205913005626 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 205913005627 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 205913005628 Protein of unknown function DUF58; Region: DUF58; pfam01882 205913005629 MoxR-like ATPases [General function prediction only]; Region: COG0714 205913005630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913005631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 205913005632 Uracil DNA glycosylase superfamily; Region: UDG; cl00483