-- dump date 20120504_134958 -- class Genbank::misc_feature -- table misc_feature_note -- id note 600809000001 transcription termination factor NusA; Region: NusA; TIGR01953 600809000002 NusA N-terminal domain; Region: NusA_N; pfam08529 600809000003 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 600809000004 RNA binding site [nucleotide binding]; other site 600809000005 homodimer interface [polypeptide binding]; other site 600809000006 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 600809000007 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 600809000008 G-X-X-G motif; other site 600809000009 translation initiation factor IF-2; Region: IF-2; TIGR00487 600809000010 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 600809000011 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 600809000012 G1 box; other site 600809000013 putative GEF interaction site [polypeptide binding]; other site 600809000014 GTP/Mg2+ binding site [chemical binding]; other site 600809000015 Switch I region; other site 600809000016 G2 box; other site 600809000017 G3 box; other site 600809000018 Switch II region; other site 600809000019 G4 box; other site 600809000020 G5 box; other site 600809000021 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 600809000022 Translation-initiation factor 2; Region: IF-2; pfam11987 600809000023 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 600809000024 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 600809000025 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 600809000026 dimer interface [polypeptide binding]; other site 600809000027 anticodon binding site; other site 600809000028 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 600809000029 homodimer interface [polypeptide binding]; other site 600809000030 motif 1; other site 600809000031 active site 600809000032 motif 2; other site 600809000033 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 600809000034 active site 600809000035 motif 3; other site 600809000036 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 600809000037 dimer interface [polypeptide binding]; other site 600809000038 substrate binding site [chemical binding]; other site 600809000039 metal binding sites [ion binding]; metal-binding site 600809000040 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 600809000041 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 600809000042 E3 interaction surface; other site 600809000043 lipoyl attachment site [posttranslational modification]; other site 600809000044 e3 binding domain; Region: E3_binding; pfam02817 600809000045 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 600809000046 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 600809000047 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 600809000048 putative substrate binding site [chemical binding]; other site 600809000049 putative ATP binding site [chemical binding]; other site 600809000050 Thiamine pyrophosphokinase; Region: TPK; cd07995 600809000051 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 600809000052 active site 600809000053 dimerization interface [polypeptide binding]; other site 600809000054 thiamine binding site [chemical binding]; other site 600809000055 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 600809000056 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 600809000057 Walker A/P-loop; other site 600809000058 ATP binding site [chemical binding]; other site 600809000059 Q-loop/lid; other site 600809000060 ABC transporter signature motif; other site 600809000061 Walker B; other site 600809000062 D-loop; other site 600809000063 H-loop/switch region; other site 600809000064 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 600809000065 PPIC-type PPIASE domain; Region: Rotamase; cl08278 600809000066 PPIC-type PPIASE domain; Region: Rotamase; cl08278 600809000067 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 600809000068 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 600809000069 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 600809000070 Walker A/P-loop; other site 600809000071 ATP binding site [chemical binding]; other site 600809000072 Q-loop/lid; other site 600809000073 ABC transporter signature motif; other site 600809000074 Walker B; other site 600809000075 D-loop; other site 600809000076 H-loop/switch region; other site 600809000077 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 600809000078 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 600809000079 dimerization interface 3.5A [polypeptide binding]; other site 600809000080 active site 600809000081 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 600809000082 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 600809000083 inhibitor-cofactor binding pocket; inhibition site 600809000084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809000085 catalytic residue [active] 600809000086 OstA-like protein; Region: OstA_2; pfam13100 600809000087 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 600809000088 homotrimer interaction site [polypeptide binding]; other site 600809000089 putative active site [active] 600809000090 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 600809000091 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 600809000092 catalytic center binding site [active] 600809000093 ATP binding site [chemical binding]; other site 600809000094 rod shape-determining protein MreB; Provisional; Region: PRK13927 600809000095 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 600809000096 ATP binding site [chemical binding]; other site 600809000097 gelsolin binding site; other site 600809000098 profilin binding site; other site 600809000099 rod shape-determining protein MreC; Region: MreC; pfam04085 600809000100 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 600809000101 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 600809000102 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 600809000103 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 600809000104 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 600809000105 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 600809000106 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 600809000107 putative active site [active] 600809000108 catalytic triad [active] 600809000109 putative dimer interface [polypeptide binding]; other site 600809000110 malate dehydrogenase; Reviewed; Region: PRK06223 600809000111 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 600809000112 NAD(P) binding site [chemical binding]; other site 600809000113 dimer interface [polypeptide binding]; other site 600809000114 tetramer (dimer of dimers) interface [polypeptide binding]; other site 600809000115 substrate binding site [chemical binding]; other site 600809000116 glycine dehydrogenase; Provisional; Region: PRK05367 600809000117 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 600809000118 tetramer interface [polypeptide binding]; other site 600809000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809000120 catalytic residue [active] 600809000121 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 600809000122 tetramer interface [polypeptide binding]; other site 600809000123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809000124 catalytic residue [active] 600809000125 UGMP family protein; Validated; Region: PRK09604 600809000126 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 600809000127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 600809000128 Family of unknown function (DUF490); Region: DUF490; pfam04357 600809000129 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 600809000130 Helix-turn-helix domains; Region: HTH; cl00088 600809000131 Helix-turn-helix domains; Region: HTH; cl00088 600809000132 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 600809000133 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 600809000134 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 600809000135 Zn2+ binding site [ion binding]; other site 600809000136 Mg2+ binding site [ion binding]; other site 600809000137 Clp protease; Region: CLP_protease; pfam00574 600809000138 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 600809000139 oligomer interface [polypeptide binding]; other site 600809000140 active site residues [active] 600809000141 MatE; Region: MatE; cl10513 600809000142 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 600809000143 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 600809000144 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 600809000145 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 600809000146 active site 600809000147 Substrate binding site; other site 600809000148 Mg++ binding site; other site 600809000149 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 600809000150 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 600809000151 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 600809000152 N-acetyl-D-glucosamine binding site [chemical binding]; other site 600809000153 catalytic residue [active] 600809000154 recombinase A; Provisional; Region: recA; PRK09354 600809000155 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 600809000156 hexamer interface [polypeptide binding]; other site 600809000157 Walker A motif; other site 600809000158 ATP binding site [chemical binding]; other site 600809000159 Walker B motif; other site 600809000160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 600809000161 ResB-like family; Region: ResB; pfam05140 600809000162 ResB-like family; Region: ResB; pfam05140 600809000163 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 600809000164 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 600809000165 putative acyl-acceptor binding pocket; other site 600809000166 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 600809000167 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 600809000168 motif 1; other site 600809000169 active site 600809000170 motif 2; other site 600809000171 motif 3; other site 600809000172 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 600809000173 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 600809000174 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 600809000175 TPP-binding site [chemical binding]; other site 600809000176 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 600809000177 dimer interface [polypeptide binding]; other site 600809000178 PYR/PP interface [polypeptide binding]; other site 600809000179 TPP binding site [chemical binding]; other site 600809000180 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 600809000181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 600809000182 E3 interaction surface; other site 600809000183 lipoyl attachment site [posttranslational modification]; other site 600809000184 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 600809000185 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 600809000186 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 600809000187 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 600809000188 ATP-grasp domain; Region: ATP-grasp_4; cl03087 600809000189 CoA-ligase; Region: Ligase_CoA; cl02894 600809000190 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 600809000191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 600809000192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809000193 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 600809000194 Walker A motif; other site 600809000195 ATP binding site [chemical binding]; other site 600809000196 Walker B motif; other site 600809000197 arginine finger; other site 600809000198 UvrB/uvrC motif; Region: UVR; pfam02151 600809000199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809000200 AAA domain; Region: AAA_22; pfam13401 600809000201 Walker A motif; other site 600809000202 ATP binding site [chemical binding]; other site 600809000203 Walker B motif; other site 600809000204 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 600809000205 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 600809000206 endonuclease III; Region: ENDO3c; smart00478 600809000207 minor groove reading motif; other site 600809000208 helix-hairpin-helix signature motif; other site 600809000209 substrate binding pocket [chemical binding]; other site 600809000210 active site 600809000211 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 600809000212 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 600809000213 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 600809000214 Domain of unknown function DUF59; Region: DUF59; cl00941 600809000215 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 600809000216 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 600809000217 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 600809000218 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 600809000219 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 600809000220 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 600809000221 Cytochrome c; Region: Cytochrom_C; cl11414 600809000222 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 600809000223 heme-binding residues [chemical binding]; other site 600809000224 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 600809000225 molybdopterin cofactor binding site; other site 600809000226 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 600809000227 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 600809000228 Polysulphide reductase, NrfD; Region: NrfD; cl01295 600809000229 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 600809000230 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 600809000231 Cytochrome c; Region: Cytochrom_C; cl11414 600809000232 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 600809000233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809000234 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 600809000235 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 600809000236 Cation transport protein; Region: TrkH; cl10514 600809000237 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 600809000238 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 600809000239 domain interfaces; other site 600809000240 active site 600809000241 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 600809000242 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 600809000243 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 600809000244 homodimer interface [polypeptide binding]; other site 600809000245 NAD binding pocket [chemical binding]; other site 600809000246 ATP binding pocket [chemical binding]; other site 600809000247 Mg binding site [ion binding]; other site 600809000248 active-site loop [active] 600809000249 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 600809000250 GTP cyclohydrolase I; Provisional; Region: PLN03044 600809000251 active site 600809000252 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 600809000253 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809000254 active site 600809000255 HIGH motif; other site 600809000256 nucleotide binding site [chemical binding]; other site 600809000257 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 600809000258 KMSKS motif; other site 600809000259 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 600809000260 tRNA binding surface [nucleotide binding]; other site 600809000261 anticodon binding site; other site 600809000262 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 600809000263 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 600809000264 homodimer interface [polypeptide binding]; other site 600809000265 substrate-cofactor binding pocket; other site 600809000266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809000267 catalytic residue [active] 600809000268 ATP synthase A chain; Region: ATP-synt_A; cl00413 600809000269 ATP synthase subunit C; Region: ATP-synt_C; cl00466 600809000270 Plant ATP synthase F0; Region: YMF19; cl07975 600809000271 Plant ATP synthase F0; Region: YMF19; cl07975 600809000272 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 600809000273 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 600809000274 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 600809000275 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 600809000276 beta subunit interaction interface [polypeptide binding]; other site 600809000277 Walker A motif; other site 600809000278 ATP binding site [chemical binding]; other site 600809000279 Walker B motif; other site 600809000280 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 600809000281 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 600809000282 ATP synthase; Region: ATP-synt; cl00365 600809000283 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 600809000284 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 600809000285 active site 600809000286 HIGH motif; other site 600809000287 dimer interface [polypeptide binding]; other site 600809000288 KMSKS motif; other site 600809000289 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 600809000290 dimer interface [polypeptide binding]; other site 600809000291 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 600809000292 chaperone protein DnaJ; Provisional; Region: PRK14289 600809000293 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 600809000294 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 600809000295 substrate binding site [polypeptide binding]; other site 600809000296 dimer interface [polypeptide binding]; other site 600809000297 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 600809000298 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 600809000299 Dehydratase family; Region: ILVD_EDD; cl00340 600809000300 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 600809000301 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 600809000302 PYR/PP interface [polypeptide binding]; other site 600809000303 dimer interface [polypeptide binding]; other site 600809000304 TPP binding site [chemical binding]; other site 600809000305 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 600809000306 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 600809000307 TPP-binding site [chemical binding]; other site 600809000308 dimer interface [polypeptide binding]; other site 600809000309 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 600809000310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809000311 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 600809000312 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 600809000313 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 600809000314 tetramer interface [polypeptide binding]; other site 600809000315 threonine dehydratase; Validated; Region: PRK08639 600809000316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809000317 catalytic residue [active] 600809000318 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 600809000319 dihydrodipicolinate reductase; Provisional; Region: PRK00048 600809000320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809000321 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 600809000322 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 600809000323 Catalytic site [active] 600809000324 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 600809000325 Rhomboid family; Region: Rhomboid; cl11446 600809000326 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 600809000327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 600809000328 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 600809000329 ATP binding site [chemical binding]; other site 600809000330 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 600809000331 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 600809000332 homopentamer interface [polypeptide binding]; other site 600809000333 active site 600809000334 Domain of unknown function DUF21; Region: DUF21; pfam01595 600809000335 gliding motility-associated protein GldE; Region: GldE; TIGR03520 600809000336 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 600809000337 Transporter associated domain; Region: CorC_HlyC; cl08393 600809000338 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 600809000339 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 600809000340 minor groove reading motif; other site 600809000341 helix-hairpin-helix signature motif; other site 600809000342 substrate binding pocket [chemical binding]; other site 600809000343 active site 600809000344 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 600809000345 DNA binding and oxoG recognition site [nucleotide binding] 600809000346 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 600809000347 IHF dimer interface [polypeptide binding]; other site 600809000348 IHF - DNA interface [nucleotide binding]; other site 600809000349 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 600809000350 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 600809000351 homodimer interface [polypeptide binding]; other site 600809000352 oligonucleotide binding site [chemical binding]; other site 600809000353 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 600809000354 Acyl transferase domain; Region: Acyl_transf_1; cl08282 600809000355 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 600809000356 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 600809000357 active site 600809000358 fumarate hydratase; Reviewed; Region: fumC; PRK00485 600809000359 Class II fumarases; Region: Fumarase_classII; cd01362 600809000360 active site 600809000361 tetramer interface [polypeptide binding]; other site 600809000362 Septum formation initiator; Region: DivIC; cl11433 600809000363 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 600809000364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809000365 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 600809000366 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 600809000367 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 600809000368 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 600809000369 active site 600809000370 catalytic site [active] 600809000371 substrate binding site [chemical binding]; other site 600809000372 exodeoxyribonuclease X; Provisional; Region: PRK07983 600809000373 heat shock protein 90; Provisional; Region: PRK05218 600809000374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 600809000375 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 600809000376 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 600809000377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 600809000378 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 600809000379 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 600809000380 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 600809000381 Transcriptional regulator; Region: Transcrip_reg; cl00361 600809000382 RmuC family; Region: RmuC; pfam02646 600809000383 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 600809000384 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 600809000385 transcription termination factor Rho; Provisional; Region: PRK12608 600809000386 RNA binding site [nucleotide binding]; other site 600809000387 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 600809000388 multimer interface [polypeptide binding]; other site 600809000389 Walker A motif; other site 600809000390 ATP binding site [chemical binding]; other site 600809000391 Walker B motif; other site 600809000392 peptide chain release factor 1; Validated; Region: prfA; PRK00591 600809000393 RF-1 domain; Region: RF-1; cl02875 600809000394 RF-1 domain; Region: RF-1; cl02875 600809000395 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 600809000396 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 600809000397 ATP-grasp domain; Region: ATP-grasp_4; cl03087 600809000398 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 600809000399 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 600809000400 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 600809000401 carboxyltransferase (CT) interaction site; other site 600809000402 biotinylation site [posttranslational modification]; other site 600809000403 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 600809000404 prolyl-tRNA synthetase; Provisional; Region: PRK08661 600809000405 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 600809000406 dimer interface [polypeptide binding]; other site 600809000407 motif 1; other site 600809000408 active site 600809000409 motif 2; other site 600809000410 motif 3; other site 600809000411 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 600809000412 anticodon binding site; other site 600809000413 zinc-binding site [ion binding]; other site 600809000414 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 600809000415 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 600809000416 active site 600809000417 FMN binding site [chemical binding]; other site 600809000418 substrate binding site [chemical binding]; other site 600809000419 catalytic residues [active] 600809000420 homodimer interface [polypeptide binding]; other site 600809000421 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 600809000422 active site 600809000423 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 600809000424 active site 600809000425 dimer interface [polypeptide binding]; other site 600809000426 MarC family integral membrane protein; Region: MarC; cl00919 600809000427 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 600809000428 AMP binding site [chemical binding]; other site 600809000429 metal binding site [ion binding]; metal-binding site 600809000430 active site 600809000431 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 600809000432 putative acyl-acceptor binding pocket; other site 600809000433 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 600809000434 active site 600809000435 RNA/DNA hybrid binding site [nucleotide binding]; other site 600809000436 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 600809000437 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 600809000438 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 600809000439 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 600809000440 active site 600809000441 Zn binding site [ion binding]; other site 600809000442 urease subunit alpha; Reviewed; Region: ureC; PRK13207 600809000443 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 600809000444 subunit interactions [polypeptide binding]; other site 600809000445 active site 600809000446 flap region; other site 600809000447 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 600809000448 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 600809000449 alpha-gamma subunit interface [polypeptide binding]; other site 600809000450 beta-gamma subunit interface [polypeptide binding]; other site 600809000451 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 600809000452 alpha-beta subunit interface [polypeptide binding]; other site 600809000453 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 600809000454 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 600809000455 putative catalytic residues [active] 600809000456 nucleotide binding site [chemical binding]; other site 600809000457 aspartate binding site [chemical binding]; other site 600809000458 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 600809000459 dimer interface [polypeptide binding]; other site 600809000460 putative threonine allosteric regulatory site; other site 600809000461 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 600809000462 putative threonine allosteric regulatory site; other site 600809000463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809000464 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 600809000465 homoserine kinase; Provisional; Region: PRK01212 600809000466 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 600809000467 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 600809000468 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 600809000469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 600809000470 catalytic residue [active] 600809000471 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 600809000472 dimerization interface [polypeptide binding]; other site 600809000473 active site 600809000474 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 600809000475 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 600809000476 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 600809000477 active site 600809000478 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 600809000479 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 600809000480 5S rRNA interface [nucleotide binding]; other site 600809000481 CTC domain interface [polypeptide binding]; other site 600809000482 L16 interface [polypeptide binding]; other site 600809000483 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 600809000484 nucleoside/Zn binding site; other site 600809000485 dimer interface [polypeptide binding]; other site 600809000486 catalytic motif [active] 600809000487 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 600809000488 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 600809000489 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 600809000490 active site 600809000491 dimer interface [polypeptide binding]; other site 600809000492 metal binding site [ion binding]; metal-binding site 600809000493 DNA gyrase subunit A; Validated; Region: PRK05560 600809000494 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 600809000495 CAP-like domain; other site 600809000496 active site 600809000497 primary dimer interface [polypeptide binding]; other site 600809000498 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 600809000499 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 600809000500 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 600809000501 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 600809000502 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 600809000503 C-terminal peptidase (prc); Region: prc; TIGR00225 600809000504 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 600809000505 protein binding site [polypeptide binding]; other site 600809000506 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 600809000507 Catalytic dyad [active] 600809000508 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 600809000509 Survival protein SurE; Region: SurE; cl00448 600809000510 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 600809000511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809000512 Walker A motif; other site 600809000513 ATP binding site [chemical binding]; other site 600809000514 Walker B motif; other site 600809000515 arginine finger; other site 600809000516 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 600809000517 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 600809000518 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 600809000519 GDP-binding site [chemical binding]; other site 600809000520 ACT binding site; other site 600809000521 IMP binding site; other site 600809000522 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 600809000523 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 600809000524 tetramer interface [polypeptide binding]; other site 600809000525 active site 600809000526 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 600809000527 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 600809000528 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 600809000529 dimerization interface [polypeptide binding]; other site 600809000530 ATP binding site [chemical binding]; other site 600809000531 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 600809000532 dimerization interface [polypeptide binding]; other site 600809000533 ATP binding site [chemical binding]; other site 600809000534 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 600809000535 conserved cys residue [active] 600809000536 AIR carboxylase; Region: AIRC; cl00310 600809000537 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 600809000538 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 600809000539 active site 600809000540 ATP binding site [chemical binding]; other site 600809000541 substrate binding site [chemical binding]; other site 600809000542 amidophosphoribosyltransferase; Provisional; Region: PRK05793 600809000543 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 600809000544 active site 600809000545 tetramer interface [polypeptide binding]; other site 600809000546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 600809000547 active site 600809000548 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 600809000549 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 600809000550 dimerization interface [polypeptide binding]; other site 600809000551 putative ATP binding site [chemical binding]; other site 600809000552 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 600809000553 active site 600809000554 substrate binding site [chemical binding]; other site 600809000555 cosubstrate binding site; other site 600809000556 catalytic site [active] 600809000557 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 600809000558 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 600809000559 purine monophosphate binding site [chemical binding]; other site 600809000560 dimer interface [polypeptide binding]; other site 600809000561 putative catalytic residues [active] 600809000562 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 600809000563 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 600809000564 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 600809000565 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 600809000566 ATP-grasp domain; Region: ATP-grasp_4; cl03087 600809000567 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 600809000568 GMP synthase; Reviewed; Region: guaA; PRK00074 600809000569 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 600809000570 AMP/PPi binding site [chemical binding]; other site 600809000571 candidate oxyanion hole; other site 600809000572 catalytic triad [active] 600809000573 potential glutamine specificity residues [chemical binding]; other site 600809000574 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 600809000575 ATP Binding subdomain [chemical binding]; other site 600809000576 Ligand Binding sites [chemical binding]; other site 600809000577 Dimerization subdomain; other site 600809000578 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 600809000579 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 600809000580 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 600809000581 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 600809000582 active site 600809000583 intersubunit interface [polypeptide binding]; other site 600809000584 zinc binding site [ion binding]; other site 600809000585 Na+ binding site [ion binding]; other site 600809000586 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 600809000587 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 600809000588 Surface antigen; Region: Bac_surface_Ag; cl03097 600809000589 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 600809000590 Family description; Region: UvrD_C_2; cl15862 600809000591 lipoyl synthase; Provisional; Region: PRK05481 600809000592 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 600809000593 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 600809000594 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 600809000595 Putative zinc ribbon domain; Region: DUF164; pfam02591 600809000596 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 600809000597 putative catalytic residue [active] 600809000598 DHH family; Region: DHH; pfam01368 600809000599 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 600809000600 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 600809000601 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 600809000602 active site 600809000603 NTP binding site [chemical binding]; other site 600809000604 metal binding triad [ion binding]; metal-binding site 600809000605 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 600809000606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 600809000607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 600809000608 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 600809000609 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 600809000610 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 600809000611 trimer interface [polypeptide binding]; other site 600809000612 active site 600809000613 substrate binding site [chemical binding]; other site 600809000614 CoA binding site [chemical binding]; other site 600809000615 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 600809000616 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 600809000617 active site 600809000618 catalytic residues [active] 600809000619 metal binding site [ion binding]; metal-binding site 600809000620 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 600809000621 23S rRNA binding site [nucleotide binding]; other site 600809000622 ribosomal protein L20; Region: rpl20; CHL00068 600809000623 L21 binding site [polypeptide binding]; other site 600809000624 L13 binding site [polypeptide binding]; other site 600809000625 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 600809000626 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 600809000627 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 600809000628 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 600809000629 active site 600809000630 dimer interface [polypeptide binding]; other site 600809000631 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 600809000632 motif 1; other site 600809000633 motif 2; other site 600809000634 motif 3; other site 600809000635 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 600809000636 anticodon binding site; other site 600809000637 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 600809000638 amphipathic channel; other site 600809000639 Asn-Pro-Ala signature motifs; other site 600809000640 glycerol kinase; Provisional; Region: glpK; PRK00047 600809000641 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 600809000642 N- and C-terminal domain interface [polypeptide binding]; other site 600809000643 active site 600809000644 MgATP binding site [chemical binding]; other site 600809000645 catalytic site [active] 600809000646 metal binding site [ion binding]; metal-binding site 600809000647 glycerol binding site [chemical binding]; other site 600809000648 homotetramer interface [polypeptide binding]; other site 600809000649 homodimer interface [polypeptide binding]; other site 600809000650 FBP binding site [chemical binding]; other site 600809000651 protein IIAGlc interface [polypeptide binding]; other site 600809000652 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 600809000653 signal recognition particle protein; Provisional; Region: PRK10867 600809000654 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 600809000655 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 600809000656 P loop; other site 600809000657 GTP binding site [chemical binding]; other site 600809000658 Signal peptide binding domain; Region: SRP_SPB; pfam02978 600809000659 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 600809000660 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 600809000661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809000662 active site 600809000663 HIGH motif; other site 600809000664 nucleotide binding site [chemical binding]; other site 600809000665 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 600809000666 KMSK motif region; other site 600809000667 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 600809000668 tRNA binding surface [nucleotide binding]; other site 600809000669 anticodon binding site; other site 600809000670 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 600809000671 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 600809000672 homodimer interface [polypeptide binding]; other site 600809000673 substrate-cofactor binding pocket; other site 600809000674 catalytic residue [active] 600809000675 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 600809000676 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 600809000677 tetramer interface [polypeptide binding]; other site 600809000678 TPP-binding site [chemical binding]; other site 600809000679 heterodimer interface [polypeptide binding]; other site 600809000680 phosphorylation loop region [posttranslational modification] 600809000681 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 600809000682 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 600809000683 PYR/PP interface [polypeptide binding]; other site 600809000684 dimer interface [polypeptide binding]; other site 600809000685 TPP binding site [chemical binding]; other site 600809000686 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 600809000687 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 600809000688 active site 600809000689 multimer interface [polypeptide binding]; other site 600809000690 LemA family; Region: LemA; cl00742 600809000691 Repair protein; Region: Repair_PSII; cl01535 600809000692 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 600809000693 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809000694 active site 600809000695 HIGH motif; other site 600809000696 nucleotide binding site [chemical binding]; other site 600809000697 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809000698 active site 600809000699 KMSKS motif; other site 600809000700 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 600809000701 tRNA binding surface [nucleotide binding]; other site 600809000702 anticodon binding site; other site 600809000703 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 600809000704 folate binding site [chemical binding]; other site 600809000705 NADP+ binding site [chemical binding]; other site 600809000706 Bifunctional nuclease; Region: DNase-RNase; cl00553 600809000707 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 600809000708 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 600809000709 alpha subunit interface [polypeptide binding]; other site 600809000710 TPP binding site [chemical binding]; other site 600809000711 heterodimer interface [polypeptide binding]; other site 600809000712 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 600809000713 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 600809000714 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 600809000715 FAD binding site [chemical binding]; other site 600809000716 seryl-tRNA synthetase; Provisional; Region: PRK05431 600809000717 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 600809000718 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 600809000719 motif 1; other site 600809000720 dimer interface [polypeptide binding]; other site 600809000721 active site 600809000722 motif 2; other site 600809000723 motif 3; other site 600809000724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809000725 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 600809000726 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 600809000727 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 600809000728 homodimer interface [polypeptide binding]; other site 600809000729 NADP binding site [chemical binding]; other site 600809000730 substrate binding site [chemical binding]; other site 600809000731 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 600809000732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 600809000733 FeS/SAM binding site; other site 600809000734 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 600809000735 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 600809000736 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 600809000737 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 600809000738 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 600809000739 substrate binding site [chemical binding]; other site 600809000740 glutamase interaction surface [polypeptide binding]; other site 600809000741 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 600809000742 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 600809000743 catalytic residues [active] 600809000744 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 600809000745 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 600809000746 putative active site [active] 600809000747 oxyanion strand; other site 600809000748 catalytic triad [active] 600809000749 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 600809000750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 600809000751 active site 600809000752 motif I; other site 600809000753 motif II; other site 600809000754 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 600809000755 putative active site pocket [active] 600809000756 4-fold oligomerization interface [polypeptide binding]; other site 600809000757 metal binding residues [ion binding]; metal-binding site 600809000758 3-fold/trimer interface [polypeptide binding]; other site 600809000759 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 600809000760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 600809000761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809000762 homodimer interface [polypeptide binding]; other site 600809000763 catalytic residue [active] 600809000764 histidinol dehydrogenase; Region: hisD; TIGR00069 600809000765 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 600809000766 NAD binding site [chemical binding]; other site 600809000767 dimerization interface [polypeptide binding]; other site 600809000768 product binding site; other site 600809000769 substrate binding site [chemical binding]; other site 600809000770 zinc binding site [ion binding]; other site 600809000771 catalytic residues [active] 600809000772 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 600809000773 ATP phosphoribosyltransferase; Region: HisG; cl15266 600809000774 HisG, C-terminal domain; Region: HisG_C; cl06867 600809000775 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 600809000776 putative active site [active] 600809000777 putative catalytic site [active] 600809000778 putative DNA binding site [nucleotide binding]; other site 600809000779 putative phosphate binding site [ion binding]; other site 600809000780 metal binding site A [ion binding]; metal-binding site 600809000781 putative AP binding site [nucleotide binding]; other site 600809000782 putative metal binding site B [ion binding]; other site 600809000783 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 600809000784 Shikimate kinase; Region: SKI; pfam01202 600809000785 ADP binding site [chemical binding]; other site 600809000786 magnesium binding site [ion binding]; other site 600809000787 putative shikimate binding site; other site 600809000788 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 600809000789 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 600809000790 Ligand Binding Site [chemical binding]; other site 600809000791 B3/4 domain; Region: B3_4; cl11458 600809000792 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 600809000793 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 600809000794 catalytic residue [active] 600809000795 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 600809000796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 600809000797 catalytic residue [active] 600809000798 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 600809000799 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 600809000800 substrate binding site [chemical binding]; other site 600809000801 active site 600809000802 catalytic residues [active] 600809000803 heterodimer interface [polypeptide binding]; other site 600809000804 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 600809000805 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 600809000806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809000807 catalytic residue [active] 600809000808 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 600809000809 active site 600809000810 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 600809000811 active site 600809000812 ribulose/triose binding site [chemical binding]; other site 600809000813 phosphate binding site [ion binding]; other site 600809000814 substrate (anthranilate) binding pocket [chemical binding]; other site 600809000815 product (indole) binding pocket [chemical binding]; other site 600809000816 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 600809000817 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 600809000818 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 600809000819 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 600809000820 Glutamine amidotransferase class-I; Region: GATase; pfam00117 600809000821 glutamine binding [chemical binding]; other site 600809000822 catalytic triad [active] 600809000823 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 600809000824 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 600809000825 chorismate binding enzyme; Region: Chorismate_bind; cl10555 600809000826 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 600809000827 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 600809000828 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 600809000829 lipoyl attachment site [posttranslational modification]; other site 600809000830 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 600809000831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 600809000832 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 600809000833 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 600809000834 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 600809000835 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 600809000836 Low-spin heme binding site [chemical binding]; other site 600809000837 D-pathway; other site 600809000838 Putative water exit pathway; other site 600809000839 Binuclear center (active site) [active] 600809000840 K-pathway; other site 600809000841 Putative proton exit pathway; other site 600809000842 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 600809000843 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 600809000844 Cytochrome c; Region: Cytochrom_C; cl11414 600809000845 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 600809000846 Malic enzyme, N-terminal domain; Region: malic; pfam00390 600809000847 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 600809000848 putative NAD(P) binding site [chemical binding]; other site 600809000849 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 600809000850 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 600809000851 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 600809000852 NlpC/P60 family; Region: NLPC_P60; cl11438 600809000853 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 600809000854 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 600809000855 hinge; other site 600809000856 active site 600809000857 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 600809000858 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 600809000859 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 600809000860 PYR/PP interface [polypeptide binding]; other site 600809000861 dimer interface [polypeptide binding]; other site 600809000862 TPP binding site [chemical binding]; other site 600809000863 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 600809000864 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 600809000865 TPP-binding site [chemical binding]; other site 600809000866 dimer interface [polypeptide binding]; other site 600809000867 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 600809000868 SmpB-tmRNA interface; other site 600809000869 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 600809000870 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 600809000871 ligand binding site [chemical binding]; other site 600809000872 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 600809000873 GTP-binding protein YchF; Reviewed; Region: PRK09601 600809000874 YchF GTPase; Region: YchF; cd01900 600809000875 G1 box; other site 600809000876 GTP/Mg2+ binding site [chemical binding]; other site 600809000877 Switch I region; other site 600809000878 G2 box; other site 600809000879 Switch II region; other site 600809000880 G3 box; other site 600809000881 G4 box; other site 600809000882 G5 box; other site 600809000883 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 600809000884 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 600809000885 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 600809000886 oligomer interface [polypeptide binding]; other site 600809000887 active site 600809000888 metal binding site [ion binding]; metal-binding site 600809000889 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 600809000890 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 600809000891 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 600809000892 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 600809000893 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 600809000894 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 600809000895 protein binding site [polypeptide binding]; other site 600809000896 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 600809000897 protein binding site [polypeptide binding]; other site 600809000898 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 600809000899 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 600809000900 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 600809000901 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 600809000902 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 600809000903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809000904 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 600809000905 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 600809000906 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 600809000907 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 600809000908 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 600809000909 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 600809000910 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 600809000911 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 600809000912 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 600809000913 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 600809000914 Mg++ binding site [ion binding]; other site 600809000915 putative catalytic motif [active] 600809000916 putative substrate binding site [chemical binding]; other site 600809000917 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 600809000918 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 600809000919 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 600809000920 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 600809000921 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 600809000922 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 600809000923 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 600809000924 homodimer interface [polypeptide binding]; other site 600809000925 active site 600809000926 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 600809000927 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 600809000928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 600809000929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 600809000930 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 600809000931 cell division protein FtsA; Region: ftsA; TIGR01174 600809000932 Cell division protein FtsA; Region: FtsA; cl11496 600809000933 Cell division protein FtsA; Region: FtsA; cl11496 600809000934 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 600809000935 nucleotide binding site [chemical binding]; other site 600809000936 SulA interaction site; other site 600809000937 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 600809000938 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 600809000939 dimer interface [polypeptide binding]; other site 600809000940 motif 1; other site 600809000941 active site 600809000942 motif 2; other site 600809000943 motif 3; other site 600809000944 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 600809000945 anticodon binding site; other site 600809000946 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 600809000947 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 600809000948 Domain of unknown function DUF59; Region: DUF59; cl00941 600809000949 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 600809000950 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 600809000951 Walker A motif; other site 600809000952 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 600809000953 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 600809000954 FAD binding domain; Region: FAD_binding_4; pfam01565 600809000955 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 600809000956 YtxH-like protein; Region: YtxH; cl02079 600809000957 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 600809000958 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 600809000959 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 600809000960 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 600809000961 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 600809000962 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 600809000963 dimer interface [polypeptide binding]; other site 600809000964 motif 1; other site 600809000965 active site 600809000966 motif 2; other site 600809000967 motif 3; other site 600809000968 AMP-binding enzyme; Region: AMP-binding; cl15778 600809000969 Phosphate transporter family; Region: PHO4; cl00396 600809000970 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 600809000971 RuvA N terminal domain; Region: RuvA_N; pfam01330 600809000972 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 600809000973 GTP-binding protein Der; Reviewed; Region: PRK00093 600809000974 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 600809000975 G1 box; other site 600809000976 GTP/Mg2+ binding site [chemical binding]; other site 600809000977 Switch I region; other site 600809000978 G2 box; other site 600809000979 Switch II region; other site 600809000980 G3 box; other site 600809000981 G4 box; other site 600809000982 G5 box; other site 600809000983 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 600809000984 G1 box; other site 600809000985 GTP/Mg2+ binding site [chemical binding]; other site 600809000986 Switch I region; other site 600809000987 G2 box; other site 600809000988 G3 box; other site 600809000989 Switch II region; other site 600809000990 G4 box; other site 600809000991 G5 box; other site 600809000992 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 600809000993 argininosuccinate lyase; Provisional; Region: PRK00855 600809000994 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 600809000995 active sites [active] 600809000996 tetramer interface [polypeptide binding]; other site 600809000997 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 600809000998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 600809000999 ATP binding site [chemical binding]; other site 600809001000 Mg2+ binding site [ion binding]; other site 600809001001 G-X-G motif; other site 600809001002 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 600809001003 anchoring element; other site 600809001004 dimer interface [polypeptide binding]; other site 600809001005 ATP binding site [chemical binding]; other site 600809001006 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 600809001007 active site 600809001008 putative metal-binding site [ion binding]; other site 600809001009 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 600809001010 Bacitracin resistance protein BacA; Region: BacA; cl00858 600809001011 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 600809001012 RNA binding site [nucleotide binding]; other site 600809001013 active site 600809001014 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 600809001015 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 600809001016 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 600809001017 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 600809001018 aspartate aminotransferase; Provisional; Region: PRK05764 600809001019 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 600809001020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809001021 homodimer interface [polypeptide binding]; other site 600809001022 catalytic residue [active] 600809001023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 600809001024 hypothetical protein; Validated; Region: PRK06886 600809001025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 600809001026 active site 600809001027 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 600809001028 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 600809001029 putative anticodon binding site; other site 600809001030 dimer interface [polypeptide binding]; other site 600809001031 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 600809001032 motif 1; other site 600809001033 active site 600809001034 motif 2; other site 600809001035 motif 3; other site 600809001036 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 600809001037 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 600809001038 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 600809001039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 600809001040 FeS/SAM binding site; other site 600809001041 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 600809001042 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 600809001043 dimer interface [polypeptide binding]; other site 600809001044 decamer (pentamer of dimers) interface [polypeptide binding]; other site 600809001045 catalytic triad [active] 600809001046 peroxidatic and resolving cysteines [active] 600809001047 DNA primase, catalytic core; Region: dnaG; TIGR01391 600809001048 CHC2 zinc finger; Region: zf-CHC2; cl15369 600809001049 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 600809001050 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 600809001051 active site 600809001052 metal binding site [ion binding]; metal-binding site 600809001053 interdomain interaction site; other site 600809001054 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 600809001055 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 600809001056 substrate binding site [chemical binding]; other site 600809001057 hexamer interface [polypeptide binding]; other site 600809001058 metal binding site [ion binding]; metal-binding site 600809001059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001060 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 600809001061 NAD(P) binding site [chemical binding]; other site 600809001062 active site 600809001063 S-adenosylmethionine synthetase; Validated; Region: PRK05250 600809001064 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 600809001065 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 600809001066 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 600809001067 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 600809001068 NeuB family; Region: NeuB; cl00496 600809001069 Chorismate mutase type II; Region: CM_2; cl00693 600809001070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001071 Prephenate dehydrogenase; Region: PDH; pfam02153 600809001072 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 600809001073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 600809001074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809001075 homodimer interface [polypeptide binding]; other site 600809001076 catalytic residue [active] 600809001077 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 600809001078 Prephenate dehydratase; Region: PDT; pfam00800 600809001079 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 600809001080 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 600809001081 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 600809001082 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 600809001083 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 600809001084 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 600809001085 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 600809001086 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 600809001087 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 600809001088 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 600809001089 HIGH motif; other site 600809001090 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 600809001091 active site 600809001092 KMSKS motif; other site 600809001093 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 600809001094 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 600809001095 trmE is a tRNA modification GTPase; Region: trmE; cd04164 600809001096 G1 box; other site 600809001097 GTP/Mg2+ binding site [chemical binding]; other site 600809001098 Switch I region; other site 600809001099 G2 box; other site 600809001100 Switch II region; other site 600809001101 G3 box; other site 600809001102 G4 box; other site 600809001103 G5 box; other site 600809001104 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 600809001105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001106 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 600809001107 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 600809001108 nucleotide binding pocket [chemical binding]; other site 600809001109 K-X-D-G motif; other site 600809001110 catalytic site [active] 600809001111 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 600809001112 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 600809001113 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 600809001114 Dimer interface [polypeptide binding]; other site 600809001115 BRCT sequence motif; other site 600809001116 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 600809001117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809001118 Walker A motif; other site 600809001119 ATP binding site [chemical binding]; other site 600809001120 Walker B motif; other site 600809001121 arginine finger; other site 600809001122 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 600809001123 diaminopimelate decarboxylase; Region: lysA; TIGR01048 600809001124 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 600809001125 active site 600809001126 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 600809001127 substrate binding site [chemical binding]; other site 600809001128 catalytic residues [active] 600809001129 dimer interface [polypeptide binding]; other site 600809001130 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 600809001131 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 600809001132 active site 600809001133 HIGH motif; other site 600809001134 KMSKS motif; other site 600809001135 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 600809001136 tRNA binding surface [nucleotide binding]; other site 600809001137 anticodon binding site; other site 600809001138 5'-3' exonuclease; Region: 53EXOc; smart00475 600809001139 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 600809001140 active site 600809001141 metal binding site 1 [ion binding]; metal-binding site 600809001142 putative 5' ssDNA interaction site; other site 600809001143 metal binding site 3; metal-binding site 600809001144 metal binding site 2 [ion binding]; metal-binding site 600809001145 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 600809001146 putative DNA binding site [nucleotide binding]; other site 600809001147 putative metal binding site [ion binding]; other site 600809001148 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 600809001149 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 600809001150 active site 600809001151 (T/H)XGH motif; other site 600809001152 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 600809001153 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 600809001154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 600809001155 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 600809001156 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 600809001157 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 600809001158 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 600809001159 catalytic residues [active] 600809001160 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 600809001161 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 600809001162 metal binding site [ion binding]; metal-binding site 600809001163 dimer interface [polypeptide binding]; other site 600809001164 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 600809001165 nucleotide binding site [chemical binding]; other site 600809001166 N-acetyl-L-glutamate binding site [chemical binding]; other site 600809001167 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 600809001168 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 600809001169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001170 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 600809001171 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 600809001172 ATP-grasp domain; Region: ATP-grasp_4; cl03087 600809001173 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 600809001174 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 600809001175 ATP-grasp domain; Region: ATP-grasp_4; cl03087 600809001176 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 600809001177 substrate binding site [chemical binding]; other site 600809001178 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 600809001179 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 600809001180 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 600809001181 catalytic site [active] 600809001182 subunit interface [polypeptide binding]; other site 600809001183 acetylornithine aminotransferase; Provisional; Region: PRK02627 600809001184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 600809001185 inhibitor-cofactor binding pocket; inhibition site 600809001186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809001187 catalytic residue [active] 600809001188 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 600809001189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001190 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 600809001191 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 600809001192 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 600809001193 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 600809001194 Ligand Binding Site [chemical binding]; other site 600809001195 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 600809001196 active site 600809001197 catalytic site [active] 600809001198 substrate binding site [chemical binding]; other site 600809001199 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 600809001200 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 600809001201 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 600809001202 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 600809001203 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 600809001204 RNA binding site [nucleotide binding]; other site 600809001205 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 600809001206 RNA binding site [nucleotide binding]; other site 600809001207 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 600809001208 RNA binding site [nucleotide binding]; other site 600809001209 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 600809001210 RNA binding site [nucleotide binding]; other site 600809001211 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 600809001212 RNA binding site [nucleotide binding]; other site 600809001213 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 600809001214 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 600809001215 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 600809001216 Class I ribonucleotide reductase; Region: RNR_I; cd01679 600809001217 active site 600809001218 dimer interface [polypeptide binding]; other site 600809001219 catalytic residues [active] 600809001220 effector binding site; other site 600809001221 R2 peptide binding site; other site 600809001222 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 600809001223 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 600809001224 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 600809001225 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 600809001226 substrate binding pocket [chemical binding]; other site 600809001227 chain length determination region; other site 600809001228 substrate-Mg2+ binding site; other site 600809001229 catalytic residues [active] 600809001230 aspartate-rich region 1; other site 600809001231 active site lid residues [active] 600809001232 aspartate-rich region 2; other site 600809001233 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 600809001234 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 600809001235 active site 600809001236 interdomain interaction site; other site 600809001237 putative metal-binding site [ion binding]; other site 600809001238 nucleotide binding site [chemical binding]; other site 600809001239 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 600809001240 domain I; other site 600809001241 DNA binding groove [nucleotide binding] 600809001242 phosphate binding site [ion binding]; other site 600809001243 domain II; other site 600809001244 domain III; other site 600809001245 nucleotide binding site [chemical binding]; other site 600809001246 catalytic site [active] 600809001247 domain IV; other site 600809001248 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 600809001249 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 600809001250 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 600809001251 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 600809001252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001253 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 600809001254 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 600809001255 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 600809001256 catalytic site [active] 600809001257 G-X2-G-X-G-K; other site 600809001258 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 600809001259 Phosphoglycerate kinase; Region: PGK; pfam00162 600809001260 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 600809001261 substrate binding site [chemical binding]; other site 600809001262 hinge regions; other site 600809001263 ADP binding site [chemical binding]; other site 600809001264 catalytic site [active] 600809001265 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 600809001266 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 600809001267 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 600809001268 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 600809001269 active site 600809001270 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 600809001271 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 600809001272 active site 600809001273 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 600809001274 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 600809001275 glutaminase active site [active] 600809001276 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 600809001277 dimer interface [polypeptide binding]; other site 600809001278 active site 600809001279 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 600809001280 dimer interface [polypeptide binding]; other site 600809001281 active site 600809001282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 600809001283 ribonuclease R; Region: RNase_R; TIGR02063 600809001284 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 600809001285 RNB domain; Region: RNB; pfam00773 600809001286 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 600809001287 RNA binding site [nucleotide binding]; other site 600809001288 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 600809001289 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809001290 active site 600809001291 nucleotide binding site [chemical binding]; other site 600809001292 HIGH motif; other site 600809001293 KMSKS motif; other site 600809001294 PSP1 C-terminal conserved region; Region: PSP1; cl00770 600809001295 Transglycosylase; Region: Transgly; cl07896 600809001296 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 600809001297 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 600809001298 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 600809001299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001300 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 600809001301 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 600809001302 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 600809001303 FAD binding pocket [chemical binding]; other site 600809001304 conserved FAD binding motif [chemical binding]; other site 600809001305 phosphate binding motif [ion binding]; other site 600809001306 beta-alpha-beta structure motif; other site 600809001307 NAD binding pocket [chemical binding]; other site 600809001308 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 600809001309 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 600809001310 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 600809001311 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 600809001312 dimer interface [polypeptide binding]; other site 600809001313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 600809001314 catalytic residue [active] 600809001315 serine O-acetyltransferase; Region: cysE; TIGR01172 600809001316 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 600809001317 trimer interface [polypeptide binding]; other site 600809001318 active site 600809001319 substrate binding site [chemical binding]; other site 600809001320 CoA binding site [chemical binding]; other site 600809001321 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 600809001322 Active Sites [active] 600809001323 AMP-binding enzyme; Region: AMP-binding; cl15778 600809001324 acyl-CoA synthetase; Validated; Region: PRK07638 600809001325 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 600809001326 metal binding site [ion binding]; metal-binding site 600809001327 substrate binding pocket [chemical binding]; other site 600809001328 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 600809001329 UbiA prenyltransferase family; Region: UbiA; cl00337 600809001330 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 600809001331 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 600809001332 substrate binding site [chemical binding]; other site 600809001333 oxyanion hole (OAH) forming residues; other site 600809001334 trimer interface [polypeptide binding]; other site 600809001335 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 600809001336 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 600809001337 transmembrane helices; other site 600809001338 enolase; Provisional; Region: eno; PRK00077 600809001339 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 600809001340 dimer interface [polypeptide binding]; other site 600809001341 metal binding site [ion binding]; metal-binding site 600809001342 substrate binding pocket [chemical binding]; other site 600809001343 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 600809001344 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 600809001345 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 600809001346 alphaNTD homodimer interface [polypeptide binding]; other site 600809001347 alphaNTD - beta interaction site [polypeptide binding]; other site 600809001348 alphaNTD - beta' interaction site [polypeptide binding]; other site 600809001349 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 600809001350 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 600809001351 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 600809001352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 600809001353 RNA binding surface [nucleotide binding]; other site 600809001354 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 600809001355 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 600809001356 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 600809001357 rRNA binding site [nucleotide binding]; other site 600809001358 predicted 30S ribosome binding site; other site 600809001359 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 600809001360 SecY translocase; Region: SecY; pfam00344 600809001361 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 600809001362 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 600809001363 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 600809001364 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 600809001365 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 600809001366 5S rRNA interface [nucleotide binding]; other site 600809001367 L27 interface [polypeptide binding]; other site 600809001368 23S rRNA interface [nucleotide binding]; other site 600809001369 L5 interface [polypeptide binding]; other site 600809001370 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 600809001371 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 600809001372 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 600809001373 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 600809001374 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 600809001375 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 600809001376 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 600809001377 KOW motif; Region: KOW; cl00354 600809001378 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 600809001379 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 600809001380 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 600809001381 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 600809001382 23S rRNA interface [nucleotide binding]; other site 600809001383 5S rRNA interface [nucleotide binding]; other site 600809001384 putative antibiotic binding site [chemical binding]; other site 600809001385 L25 interface [polypeptide binding]; other site 600809001386 L27 interface [polypeptide binding]; other site 600809001387 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 600809001388 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 600809001389 G-X-X-G motif; other site 600809001390 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 600809001391 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 600809001392 putative translocon binding site; other site 600809001393 protein-rRNA interface [nucleotide binding]; other site 600809001394 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 600809001395 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 600809001396 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 600809001397 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 600809001398 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 600809001399 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 600809001400 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 600809001401 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 600809001402 elongation factor G; Reviewed; Region: PRK12739 600809001403 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 600809001404 G1 box; other site 600809001405 putative GEF interaction site [polypeptide binding]; other site 600809001406 GTP/Mg2+ binding site [chemical binding]; other site 600809001407 Switch I region; other site 600809001408 G2 box; other site 600809001409 G3 box; other site 600809001410 Switch II region; other site 600809001411 G4 box; other site 600809001412 G5 box; other site 600809001413 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 600809001414 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 600809001415 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 600809001416 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 600809001417 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 600809001418 S17 interaction site [polypeptide binding]; other site 600809001419 S8 interaction site; other site 600809001420 16S rRNA interaction site [nucleotide binding]; other site 600809001421 streptomycin interaction site [chemical binding]; other site 600809001422 23S rRNA interaction site [nucleotide binding]; other site 600809001423 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 600809001424 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 600809001425 active site 600809001426 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 600809001427 Sulfatase; Region: Sulfatase; cl10460 600809001428 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 600809001429 Elongation factor TS; Region: EF_TS; pfam00889 600809001430 elongation factor Ts; Reviewed; Region: tsf; PRK12332 600809001431 Elongation factor TS; Region: EF_TS; pfam00889 600809001432 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 600809001433 rRNA interaction site [nucleotide binding]; other site 600809001434 S8 interaction site; other site 600809001435 putative laminin-1 binding site; other site 600809001436 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 600809001437 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 600809001438 23S rRNA interface [nucleotide binding]; other site 600809001439 L3 interface [polypeptide binding]; other site 600809001440 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 600809001441 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 600809001442 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 600809001443 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 600809001444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809001445 Walker A motif; other site 600809001446 ATP binding site [chemical binding]; other site 600809001447 Walker B motif; other site 600809001448 arginine finger; other site 600809001449 Peptidase family M41; Region: Peptidase_M41; pfam01434 600809001450 Oligomerisation domain; Region: Oligomerisation; cl00519 600809001451 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 600809001452 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 600809001453 membrane protein insertase; Provisional; Region: PRK01318 600809001454 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 600809001455 CTP synthetase; Validated; Region: pyrG; PRK05380 600809001456 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 600809001457 Catalytic site [active] 600809001458 active site 600809001459 UTP binding site [chemical binding]; other site 600809001460 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 600809001461 active site 600809001462 putative oxyanion hole; other site 600809001463 catalytic triad [active] 600809001464 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 600809001465 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 600809001466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809001467 Walker A motif; other site 600809001468 ATP binding site [chemical binding]; other site 600809001469 Walker B motif; other site 600809001470 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 600809001471 GTPase CgtA; Reviewed; Region: obgE; PRK12299 600809001472 GTP1/OBG; Region: GTP1_OBG; pfam01018 600809001473 Obg GTPase; Region: Obg; cd01898 600809001474 G1 box; other site 600809001475 GTP/Mg2+ binding site [chemical binding]; other site 600809001476 Switch I region; other site 600809001477 G2 box; other site 600809001478 G3 box; other site 600809001479 Switch II region; other site 600809001480 G4 box; other site 600809001481 G5 box; other site 600809001482 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 600809001483 adenylate kinases; Region: adk; TIGR01351 600809001484 AMP-binding site [chemical binding]; other site 600809001485 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 600809001486 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 600809001487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 600809001489 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 600809001490 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 600809001491 active site 600809001492 intersubunit interactions; other site 600809001493 catalytic residue [active] 600809001494 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 600809001495 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 600809001496 Ferritin-like domain; Region: Ferritin; pfam00210 600809001497 ferroxidase diiron center [ion binding]; other site 600809001498 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 600809001499 dihydrodipicolinate synthase; Region: dapA; TIGR00674 600809001500 dimer interface [polypeptide binding]; other site 600809001501 active site 600809001502 catalytic residue [active] 600809001503 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 600809001504 RNA/DNA binding site [nucleotide binding]; other site 600809001505 RRM dimerization site [polypeptide binding]; other site 600809001506 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 600809001507 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 600809001508 active site 600809001509 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 600809001510 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 600809001511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 600809001512 FeS/SAM binding site; other site 600809001513 TRAM domain; Region: TRAM; cl01282 600809001514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809001515 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 600809001516 Walker A motif; other site 600809001517 ATP binding site [chemical binding]; other site 600809001518 Walker B motif; other site 600809001519 arginine finger; other site 600809001520 Helix-turn-helix domains; Region: HTH; cl00088 600809001521 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 600809001522 oligomerisation interface [polypeptide binding]; other site 600809001523 mobile loop; other site 600809001524 roof hairpin; other site 600809001525 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 600809001526 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 600809001527 ring oligomerisation interface [polypeptide binding]; other site 600809001528 ATP/Mg binding site [chemical binding]; other site 600809001529 stacking interactions; other site 600809001530 hinge regions; other site 600809001531 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 600809001532 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 600809001533 Protein of unknown function (DUF3276); Region: DUF3276; cl15305 600809001534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 600809001535 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 600809001536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 600809001537 Walker A/P-loop; other site 600809001538 ATP binding site [chemical binding]; other site 600809001539 Q-loop/lid; other site 600809001540 ABC transporter signature motif; other site 600809001541 Walker B; other site 600809001542 D-loop; other site 600809001543 H-loop/switch region; other site 600809001544 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 600809001545 Preprotein translocase subunit; Region: YajC; cl00806 600809001546 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 600809001547 CoA-binding site [chemical binding]; other site 600809001548 ATP-binding [chemical binding]; other site 600809001549 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 600809001550 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 600809001551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 600809001553 chorismate binding enzyme; Region: Chorismate_bind; cl10555 600809001554 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 600809001555 CoenzymeA binding site [chemical binding]; other site 600809001556 subunit interaction site [polypeptide binding]; other site 600809001557 PHB binding site; other site 600809001558 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 600809001559 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 600809001560 nudix motif; other site 600809001561 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 600809001562 active site 600809001563 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 600809001564 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 600809001565 MatE; Region: MatE; cl10513 600809001566 MatE; Region: MatE; cl10513 600809001567 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 600809001568 DEAD-like helicases superfamily; Region: DEXDc; smart00487 600809001569 ATP binding site [chemical binding]; other site 600809001570 Mg++ binding site [ion binding]; other site 600809001571 motif III; other site 600809001572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 600809001573 nucleotide binding region [chemical binding]; other site 600809001574 ATP-binding site [chemical binding]; other site 600809001575 DbpA RNA binding domain; Region: DbpA; pfam03880 600809001576 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 600809001577 Tetramer interface [polypeptide binding]; other site 600809001578 active site 600809001579 FMN-binding site [chemical binding]; other site 600809001580 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 600809001581 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 600809001582 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 600809001583 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 600809001584 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809001585 active site 600809001586 HIGH motif; other site 600809001587 nucleotide binding site [chemical binding]; other site 600809001588 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809001589 active site 600809001590 KMSKS motif; other site 600809001591 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 600809001592 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 600809001593 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 600809001594 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 600809001595 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 600809001596 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 600809001597 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 600809001598 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 600809001599 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 600809001600 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 600809001601 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 600809001602 DNA binding site [nucleotide binding] 600809001603 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 600809001604 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 600809001605 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 600809001606 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 600809001607 RPB12 interaction site [polypeptide binding]; other site 600809001608 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 600809001609 RPB11 interaction site [polypeptide binding]; other site 600809001610 RPB12 interaction site [polypeptide binding]; other site 600809001611 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 600809001612 RPB3 interaction site [polypeptide binding]; other site 600809001613 RPB1 interaction site [polypeptide binding]; other site 600809001614 RPB11 interaction site [polypeptide binding]; other site 600809001615 RPB10 interaction site [polypeptide binding]; other site 600809001616 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 600809001617 peripheral dimer interface [polypeptide binding]; other site 600809001618 core dimer interface [polypeptide binding]; other site 600809001619 L10 interface [polypeptide binding]; other site 600809001620 L11 interface [polypeptide binding]; other site 600809001621 putative EF-Tu interaction site [polypeptide binding]; other site 600809001622 putative EF-G interaction site [polypeptide binding]; other site 600809001623 Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with...; Region: Ribosomal_L10_P0; cl00376 600809001624 23S rRNA interface [nucleotide binding]; other site 600809001625 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 600809001626 mRNA/rRNA interface [nucleotide binding]; other site 600809001627 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 600809001628 23S rRNA interface [nucleotide binding]; other site 600809001629 putative thiostrepton binding site; other site 600809001630 L7/L12 interface [polypeptide binding]; other site 600809001631 L25 interface [polypeptide binding]; other site 600809001632 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 600809001633 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 600809001634 putative homodimer interface [polypeptide binding]; other site 600809001635 KOW motif; Region: KOW; cl00354 600809001636 elongation factor Tu; Reviewed; Region: PRK12735 600809001637 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 600809001638 G1 box; other site 600809001639 GEF interaction site [polypeptide binding]; other site 600809001640 GTP/Mg2+ binding site [chemical binding]; other site 600809001641 Switch I region; other site 600809001642 G2 box; other site 600809001643 G3 box; other site 600809001644 Switch II region; other site 600809001645 G4 box; other site 600809001646 G5 box; other site 600809001647 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 600809001648 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 600809001649 Antibiotic Binding Site [chemical binding]; other site 600809001650 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 600809001651 lipoprotein signal peptidase; Provisional; Region: PRK14787 600809001652 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 600809001653 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 600809001654 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809001655 active site 600809001656 HIGH motif; other site 600809001657 nucleotide binding site [chemical binding]; other site 600809001658 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 600809001659 active site 600809001660 KMSKS motif; other site 600809001661 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 600809001662 tRNA binding surface [nucleotide binding]; other site 600809001663 anticodon binding site; other site 600809001664 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 600809001665 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 600809001666 MutS domain I; Region: MutS_I; pfam01624 600809001667 MutS domain II; Region: MutS_II; pfam05188 600809001668 MutS family domain IV; Region: MutS_IV; pfam05190 600809001669 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 600809001670 Walker A/P-loop; other site 600809001671 ATP binding site [chemical binding]; other site 600809001672 Q-loop/lid; other site 600809001673 ABC transporter signature motif; other site 600809001674 Walker B; other site 600809001675 D-loop; other site 600809001676 H-loop/switch region; other site 600809001677 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 600809001678 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 600809001679 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 600809001680 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 600809001681 active site 600809001682 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 600809001683 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 600809001684 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 600809001685 active site 600809001686 substrate binding site [chemical binding]; other site 600809001687 metal binding site [ion binding]; metal-binding site 600809001688 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 600809001689 replicative DNA helicase; Region: DnaB; TIGR00665 600809001690 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 600809001691 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 600809001692 Walker A motif; other site 600809001693 ATP binding site [chemical binding]; other site 600809001694 Walker B motif; other site 600809001695 DNA binding loops [nucleotide binding] 600809001696 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 600809001697 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 600809001698 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 600809001699 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 600809001700 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 600809001701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001702 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 600809001703 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 600809001704 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 600809001705 putative Iron-sulfur protein interface [polypeptide binding]; other site 600809001706 proximal heme binding site [chemical binding]; other site 600809001707 distal heme binding site [chemical binding]; other site 600809001708 putative dimer interface [polypeptide binding]; other site 600809001709 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 600809001710 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 600809001711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 600809001712 catalytic residue [active] 600809001713 phosphodiesterase; Provisional; Region: PRK12704 600809001714 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 600809001715 Deoxyhypusine synthase; Region: DS; cl00826 600809001716 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 600809001717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809001718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 600809001719 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 600809001720 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 600809001721 ligand binding site [chemical binding]; other site 600809001722 active site 600809001723 UGI interface [polypeptide binding]; other site 600809001724 catalytic site [active] 600809001725 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 600809001726 Fatty acid desaturase; Region: FA_desaturase; pfam00487 600809001727 putative di-iron ligands [ion binding]; other site 600809001728 4Fe-4S binding domain; Region: Fer4; cl02805 600809001729 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 600809001730 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 600809001731 catalytic motif [active] 600809001732 Zn binding site [ion binding]; other site 600809001733 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 600809001734 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 600809001735 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 600809001736 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 600809001737 shikimate binding site; other site 600809001738 NAD(P) binding site [chemical binding]; other site 600809001739 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 600809001740 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 600809001741 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 600809001742 generic binding surface II; other site 600809001743 ssDNA binding site; other site 600809001744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 600809001745 ATP binding site [chemical binding]; other site 600809001746 putative Mg++ binding site [ion binding]; other site 600809001747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 600809001748 nucleotide binding region [chemical binding]; other site 600809001749 ATP-binding site [chemical binding]; other site 600809001750 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 600809001751 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 600809001752 Family description; Region: UvrD_C_2; cl15862 600809001753 Cation efflux family; Region: Cation_efflux; cl00316 600809001754 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 600809001755 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 600809001756 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 600809001757 hinge; other site 600809001758 active site 600809001759 Staphylococcal nuclease homologues; Region: SNc; smart00318 600809001760 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 600809001761 Catalytic site; other site 600809001762 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 600809001763 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 600809001764 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 600809001765 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 600809001766 nucleotide binding site/active site [active] 600809001767 HIT family signature motif; other site 600809001768 catalytic residue [active] 600809001769 Type III pantothenate kinase; Region: Pan_kinase; cl09130 600809001770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 600809001771 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 600809001772 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 600809001773 RIP metalloprotease RseP; Region: TIGR00054 600809001774 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 600809001775 active site 600809001776 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 600809001777 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 600809001778 protein binding site [polypeptide binding]; other site 600809001779 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 600809001780 putative substrate binding region [chemical binding]; other site 600809001781 FeoA domain; Region: FeoA; cl00838 600809001782 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 600809001783 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 600809001784 G1 box; other site 600809001785 GTP/Mg2+ binding site [chemical binding]; other site 600809001786 Switch I region; other site 600809001787 G2 box; other site 600809001788 G3 box; other site 600809001789 Switch II region; other site 600809001790 G4 box; other site 600809001791 G5 box; other site 600809001792 Nucleoside recognition; Region: Gate; cl00486 600809001793 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 600809001794 Nucleoside recognition; Region: Gate; cl00486 600809001795 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 600809001796 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 600809001797 ATP-grasp domain; Region: ATP-grasp_4; cl03087 600809001798 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 600809001799 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 600809001800 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 600809001801 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 600809001802 RNA binding surface [nucleotide binding]; other site 600809001803 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 600809001804 active site 600809001805 MgtE intracellular N domain; Region: MgtE_N; cl15244 600809001806 FOG: CBS domain [General function prediction only]; Region: COG0517 600809001807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 600809001808 Divalent cation transporter; Region: MgtE; cl00786 600809001809 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 600809001810 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809001811 active site 600809001812 HIGH motif; other site 600809001813 nucleotide binding site [chemical binding]; other site 600809001814 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 600809001815 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809001816 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809001817 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 600809001818 active site 600809001819 KMSKS motif; other site 600809001820 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 600809001821 tRNA binding surface [nucleotide binding]; other site 600809001822 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 600809001823 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 600809001824 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 600809001825 NAD(P) binding site [chemical binding]; other site 600809001826 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 600809001827 putative nucleotide binding site [chemical binding]; other site 600809001828 uridine monophosphate binding site [chemical binding]; other site 600809001829 homohexameric interface [polypeptide binding]; other site 600809001830 ribosome recycling factor; Reviewed; Region: frr; PRK00083 600809001831 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cl00240 600809001832 hinge region; other site 600809001833 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 600809001834 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 600809001835 putative dimer interface [polypeptide binding]; other site 600809001836 putative anticodon binding site; other site 600809001837 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 600809001838 homodimer interface [polypeptide binding]; other site 600809001839 motif 1; other site 600809001840 motif 2; other site 600809001841 active site 600809001842 motif 3; other site 600809001843 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 600809001844 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 600809001845 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 600809001846 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 600809001847 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 600809001848 NAD(P) binding site [chemical binding]; other site 600809001849 catalytic residues [active] 600809001850 Fe-S metabolism associated domain; Region: SufE; cl00951 600809001851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 600809001852 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 600809001853 THF binding site; other site 600809001854 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 600809001855 substrate binding site [chemical binding]; other site 600809001856 THF binding site; other site 600809001857 zinc-binding site [ion binding]; other site 600809001858 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 600809001859 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 600809001860 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 600809001861 putative trimer interface [polypeptide binding]; other site 600809001862 putative CoA binding site [chemical binding]; other site 600809001863 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 600809001864 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 600809001865 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 600809001866 dimer interface [polypeptide binding]; other site 600809001867 active site 600809001868 CoA binding pocket [chemical binding]; other site 600809001869 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 600809001870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 600809001871 S-adenosylmethionine binding site [chemical binding]; other site 600809001872 GH3 auxin-responsive promoter; Region: GH3; cl04006 600809001873 S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic...; Region: S15_NS1_EPRS_RNA-bind; cl00349 600809001874 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 600809001875 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 600809001876 RNase E interface [polypeptide binding]; other site 600809001877 trimer interface [polypeptide binding]; other site 600809001878 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 600809001879 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 600809001880 RNase E interface [polypeptide binding]; other site 600809001881 trimer interface [polypeptide binding]; other site 600809001882 active site 600809001883 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 600809001884 putative nucleic acid binding region [nucleotide binding]; other site 600809001885 G-X-X-G motif; other site 600809001886 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 600809001887 RNA binding site [nucleotide binding]; other site 600809001888 domain interface; other site 600809001889 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 600809001890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 600809001891 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 600809001892 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 600809001893 DNA binding residues [nucleotide binding] 600809001894 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 600809001895 substrate binding site [chemical binding]; other site 600809001896 dimer interface [polypeptide binding]; other site 600809001897 catalytic triad [active] 600809001898 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 600809001899 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 600809001900 dihydropteroate synthase; Region: DHPS; TIGR01496 600809001901 substrate binding pocket [chemical binding]; other site 600809001902 dimer interface [polypeptide binding]; other site 600809001903 inhibitor binding site; inhibition site 600809001904 Uncharacterized conserved protein [Function unknown]; Region: COG1624 600809001905 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 600809001906 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 600809001907 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 600809001908 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 600809001909 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 600809001910 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 600809001911 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 600809001912 tetramer interface [polypeptide binding]; other site 600809001913 TPP-binding site [chemical binding]; other site 600809001914 heterodimer interface [polypeptide binding]; other site 600809001915 phosphorylation loop region [posttranslational modification] 600809001916 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 600809001917 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 600809001918 E3 interaction surface; other site 600809001919 lipoyl attachment site [posttranslational modification]; other site 600809001920 e3 binding domain; Region: E3_binding; pfam02817 600809001921 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 600809001922 Integral membrane protein TerC family; Region: TerC; cl10468 600809001923 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 600809001924 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 600809001925 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 600809001926 Protein export membrane protein; Region: SecD_SecF; cl14618 600809001927 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 600809001928 Protein export membrane protein; Region: SecD_SecF; cl14618 600809001929 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 600809001930 SurA N-terminal domain; Region: SurA_N_3; cl07813 600809001931 PPIC-type PPIASE domain; Region: Rotamase; cl08278 600809001932 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 600809001933 Domain of unknown function DUF21; Region: DUF21; pfam01595 600809001934 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 600809001935 Transporter associated domain; Region: CorC_HlyC; cl08393 600809001936 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 600809001937 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 600809001938 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 600809001939 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 600809001940 Surface antigen; Region: Bac_surface_Ag; cl03097 600809001941 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 600809001942 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 600809001943 catalytic residue [active] 600809001944 putative FPP diphosphate binding site; other site 600809001945 putative FPP binding hydrophobic cleft; other site 600809001946 dimer interface [polypeptide binding]; other site 600809001947 putative IPP diphosphate binding site; other site 600809001948 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 600809001949 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 600809001950 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 600809001951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 600809001952 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 600809001953 RNA binding surface [nucleotide binding]; other site 600809001954 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 600809001955 active site 600809001956 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 600809001957 trimer interface [polypeptide binding]; other site 600809001958 active site 600809001959 dimer interface [polypeptide binding]; other site 600809001960 Predicted GTPase [General function prediction only]; Region: COG0218 600809001961 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 600809001962 G1 box; other site 600809001963 GTP/Mg2+ binding site [chemical binding]; other site 600809001964 Switch I region; other site 600809001965 G2 box; other site 600809001966 G3 box; other site 600809001967 Switch II region; other site 600809001968 G4 box; other site 600809001969 G5 box; other site 600809001970 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 600809001971 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 600809001972 dimerization interface [polypeptide binding]; other site 600809001973 active site 600809001974 metal binding site [ion binding]; metal-binding site 600809001975 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 600809001976 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 600809001977 dimer interface [polypeptide binding]; other site 600809001978 active site 600809001979 Phosphopantetheine attachment site; Region: PP-binding; cl09936 600809001980 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 600809001981 active site 600809001982 substrate-binding site [chemical binding]; other site 600809001983 metal-binding site [ion binding] 600809001984 ATP binding site [chemical binding]; other site 600809001985 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 600809001986 Lumazine binding domain; Region: Lum_binding; pfam00677 600809001987 Lumazine binding domain; Region: Lum_binding; pfam00677 600809001988 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 600809001989 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 600809001990 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 600809001991 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 600809001992 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 600809001993 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 600809001994 alpha subunit interaction interface [polypeptide binding]; other site 600809001995 Walker A motif; other site 600809001996 ATP binding site [chemical binding]; other site 600809001997 Walker B motif; other site 600809001998 inhibitor binding site; inhibition site 600809001999 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 600809002000 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 600809002001 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 600809002002 active site 600809002003 Riboflavin kinase; Region: Flavokinase; cl03312 600809002004 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 600809002005 tartrate dehydrogenase; Provisional; Region: PRK08194 600809002006 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 600809002007 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 600809002008 substrate binding site [chemical binding]; other site 600809002009 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 600809002010 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 600809002011 substrate binding site [chemical binding]; other site 600809002012 ligand binding site [chemical binding]; other site 600809002013 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 600809002014 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 600809002015 active site 600809002016 catalytic residues [active] 600809002017 metal binding site [ion binding]; metal-binding site 600809002018 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 600809002019 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 600809002020 active site 600809002021 HIGH motif; other site 600809002022 dimer interface [polypeptide binding]; other site 600809002023 KMSKS motif; other site 600809002024 GTPase Era; Reviewed; Region: era; PRK00089 600809002025 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 600809002026 G1 box; other site 600809002027 GTP/Mg2+ binding site [chemical binding]; other site 600809002028 Switch I region; other site 600809002029 G2 box; other site 600809002030 Switch II region; other site 600809002031 G3 box; other site 600809002032 G4 box; other site 600809002033 G5 box; other site 600809002034 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 600809002035 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 600809002036 Clp amino terminal domain; Region: Clp_N; pfam02861 600809002037 Clp amino terminal domain; Region: Clp_N; pfam02861 600809002038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809002039 Walker A motif; other site 600809002040 ATP binding site [chemical binding]; other site 600809002041 Walker B motif; other site 600809002042 arginine finger; other site 600809002043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 600809002044 Walker A motif; other site 600809002045 ATP binding site [chemical binding]; other site 600809002046 Walker B motif; other site 600809002047 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 600809002048 peptide chain release factor 2; Validated; Region: prfB; PRK00578 600809002049 RF-1 domain; Region: RF-1; cl02875 600809002050 RF-1 domain; Region: RF-1; cl02875 600809002051 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 600809002052 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 600809002053 dimer interface [polypeptide binding]; other site 600809002054 active site 600809002055 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 600809002056 catalytic residues [active] 600809002057 substrate binding site [chemical binding]; other site 600809002058 Arginase family; Region: Arginase; cl00306 600809002059 cytidylate kinase; Provisional; Region: cmk; PRK00023 600809002060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 600809002061 active site 600809002062 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 600809002063 CMP-binding site; other site 600809002064 The sites determining sugar specificity; other site 600809002065 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 600809002066 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 600809002067 NAD(P) binding site [chemical binding]; other site 600809002068 homotetramer interface [polypeptide binding]; other site 600809002069 homodimer interface [polypeptide binding]; other site 600809002070 active site 600809002071 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 600809002072 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 600809002073 dimer interface [polypeptide binding]; other site 600809002074 tetramer interface [polypeptide binding]; other site 600809002075 PYR/PP interface [polypeptide binding]; other site 600809002076 TPP binding site [chemical binding]; other site 600809002077 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 600809002078 TPP-binding site; other site 600809002079 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 600809002080 putative active site [active] 600809002081 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 600809002082 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 600809002083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 600809002084 nucleotide binding region [chemical binding]; other site 600809002085 ATP-binding site [chemical binding]; other site 600809002086 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 600809002087 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 600809002088 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 600809002089 putative active site [active] 600809002090 substrate binding site [chemical binding]; other site 600809002091 putative cosubstrate binding site; other site 600809002092 catalytic site [active] 600809002093 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 600809002094 substrate binding site [chemical binding]; other site 600809002095 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 600809002096 IHF - DNA interface [nucleotide binding]; other site 600809002097 IHF dimer interface [polypeptide binding]; other site 600809002098 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 600809002099 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 600809002100 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 600809002101 DNA polymerase III subunit beta; Validated; Region: PRK05643 600809002102 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 600809002103 putative DNA binding surface [nucleotide binding]; other site 600809002104 dimer interface [polypeptide binding]; other site 600809002105 beta-clamp/translesion DNA polymerase binding surface; other site 600809002106 beta-clamp/clamp loader binding surface; other site 600809002107 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 600809002108 B3/4 domain; Region: B3_4; cl11458 600809002109 tRNA synthetase B5 domain; Region: B5; cl08394 600809002110 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 600809002111 dimer interface [polypeptide binding]; other site 600809002112 motif 1; other site 600809002113 motif 3; other site 600809002114 motif 2; other site 600809002115 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 600809002116 glycyl-tRNA synthetase; Provisional; Region: PRK04173 600809002117 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 600809002118 motif 1; other site 600809002119 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 600809002120 active site 600809002121 dimer interface [polypeptide binding]; other site 600809002122 motif 2; other site 600809002123 motif 3; other site 600809002124 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 600809002125 anticodon binding site; other site 600809002126 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 600809002127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 600809002128 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 600809002129 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 600809002130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809002131 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 600809002132 GTP-binding protein LepA; Provisional; Region: PRK05433 600809002133 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 600809002134 G1 box; other site 600809002135 putative GEF interaction site [polypeptide binding]; other site 600809002136 GTP/Mg2+ binding site [chemical binding]; other site 600809002137 Switch I region; other site 600809002138 G2 box; other site 600809002139 G3 box; other site 600809002140 Switch II region; other site 600809002141 G4 box; other site 600809002142 G5 box; other site 600809002143 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 600809002144 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 600809002145 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 600809002146 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 600809002147 putative active site [active] 600809002148 catalytic residue [active] 600809002149 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 600809002150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 600809002151 CoA-ligase; Region: Ligase_CoA; cl02894 600809002152 elongation factor P; Validated; Region: PRK00529 600809002153 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 600809002154 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 600809002155 RNA binding site [nucleotide binding]; other site 600809002156 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 600809002157 RNA binding site [nucleotide binding]; other site 600809002158 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 600809002159 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 600809002160 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 600809002161 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 600809002162 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 600809002163 putative active site [active] 600809002164 Zn binding site [ion binding]; other site 600809002165 CAAX protease self-immunity; Region: Abi; cl00558 600809002166 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 600809002167 active site 600809002168 dimerization interface [polypeptide binding]; other site 600809002169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 600809002170 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 600809002171 FtsX-like permease family; Region: FtsX; cl15850 600809002172 Ribosome-binding factor A; Region: RBFA; cl00542 600809002173 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 600809002174 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 600809002175 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 600809002176 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 600809002177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 600809002178 catalytic residue [active] 600809002179 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 600809002180 FeS assembly ATPase SufC; Region: sufC; TIGR01978 600809002181 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 600809002182 Walker A/P-loop; other site 600809002183 ATP binding site [chemical binding]; other site 600809002184 Q-loop/lid; other site 600809002185 ABC transporter signature motif; other site 600809002186 Walker B; other site 600809002187 D-loop; other site 600809002188 H-loop/switch region; other site 600809002189 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 600809002190 putative ABC transporter; Region: ycf24; CHL00085 600809002191 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 600809002192 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 600809002193 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 600809002194 Haemolytic domain; Region: Haemolytic; cl00506 600809002195 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 600809002196 acyl-CoA esterase; Provisional; Region: PRK10673 600809002197 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 600809002198 active site 600809002199 hydrophilic channel; other site 600809002200 dimerization interface [polypeptide binding]; other site 600809002201 catalytic residues [active] 600809002202 active site lid [active] 600809002203 Mechanosensitive ion channel; Region: MS_channel; pfam00924 600809002204 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 600809002205 trimer interface [polypeptide binding]; other site 600809002206 active site 600809002207 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 600809002208 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 600809002209 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 600809002210 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 600809002211 dimer interface [polypeptide binding]; other site 600809002212 putative radical transfer pathway; other site 600809002213 diiron center [ion binding]; other site 600809002214 tyrosyl radical; other site