-- dump date 20120504_135107 -- class Genbank::misc_feature -- table misc_feature_note -- id note 521010000001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 521010000002 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000003 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000004 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000005 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000006 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000007 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000008 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000009 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000010 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000011 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000012 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000013 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000014 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000015 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000016 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000017 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000018 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000019 DUF276; Region: DUF276; pfam03434 521010000020 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000021 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000022 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000023 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000024 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000025 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000026 ERF superfamily; Region: ERF; pfam04404 521010000027 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000028 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000029 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000030 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000031 P-loop; other site 521010000032 Magnesium ion binding site [ion binding]; other site 521010000033 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000034 Magnesium ion binding site [ion binding]; other site 521010000035 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000036 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000037 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000038 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000039 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000040 active site 521010000041 Int/Topo IB signature motif; other site 521010000042 catalytic residues [active] 521010000043 DNA binding site [nucleotide binding] 521010000044 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000045 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000046 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000047 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000048 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000049 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 521010000051 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000052 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000053 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000054 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000055 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000056 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000057 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000058 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000059 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000060 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000061 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000062 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000063 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000064 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000065 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000066 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000067 DUF276; Region: DUF276; pfam03434 521010000068 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000069 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000070 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000071 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000072 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000073 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 521010000074 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000075 ERF superfamily; Region: ERF; pfam04404 521010000076 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000077 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000078 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000080 P-loop; other site 521010000081 Magnesium ion binding site [ion binding]; other site 521010000082 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000083 Magnesium ion binding site [ion binding]; other site 521010000084 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000085 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 521010000086 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000087 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000088 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000089 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000090 active site 521010000091 Int/Topo IB signature motif; other site 521010000092 catalytic residues [active] 521010000093 DNA binding site [nucleotide binding] 521010000094 Borrelia outer surface protein E; Region: OspE; pfam02471 521010000095 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000096 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000097 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000098 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000099 Terminase-like family; Region: Terminase_6; pfam03237 521010000100 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 521010000102 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000103 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000104 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000105 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000106 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000107 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000108 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000109 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000110 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000111 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000112 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000113 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000114 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000115 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000116 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000117 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000118 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000119 DUF276; Region: DUF276; pfam03434 521010000120 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000121 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000122 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000123 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000124 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000125 ERF superfamily; Region: ERF; pfam04404 521010000126 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000127 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000128 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000129 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000130 P-loop; other site 521010000131 Magnesium ion binding site [ion binding]; other site 521010000132 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000133 Magnesium ion binding site [ion binding]; other site 521010000134 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000135 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 521010000136 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000137 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000138 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000139 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000140 active site 521010000141 catalytic residues [active] 521010000142 DNA binding site [nucleotide binding] 521010000143 Int/Topo IB signature motif; other site 521010000144 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000145 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000146 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000147 Terminase-like family; Region: Terminase_6; pfam03237 521010000148 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 521010000150 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000151 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000152 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000153 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000154 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000155 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000156 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000157 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000158 ERF superfamily; Region: ERF; pfam04404 521010000159 ERF superfamily; Region: ERF; pfam04404 521010000160 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000161 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000162 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000163 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000164 P-loop; other site 521010000165 Magnesium ion binding site [ion binding]; other site 521010000166 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000167 Magnesium ion binding site [ion binding]; other site 521010000168 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000169 AAA domain; Region: AAA_13; pfam13166 521010000170 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000171 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000172 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000173 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000174 active site 521010000175 catalytic residues [active] 521010000176 DNA binding site [nucleotide binding] 521010000177 Int/Topo IB signature motif; other site 521010000178 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 521010000179 TM2 domain; Region: TM2; cl00984 521010000180 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000181 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000182 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000183 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521010000184 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000185 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000186 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000187 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000188 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000189 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000190 Magnesium ion binding site [ion binding]; other site 521010000191 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000192 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 521010000193 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000194 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000195 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000196 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000197 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000198 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000199 Borrelia outer surface protein E; Region: OspE; pfam02471 521010000200 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000201 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000202 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000203 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521010000204 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000205 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000206 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000207 P-loop; other site 521010000208 Magnesium ion binding site [ion binding]; other site 521010000209 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000210 Magnesium ion binding site [ion binding]; other site 521010000211 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000212 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000213 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000214 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000215 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 521010000216 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000217 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000218 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000219 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000220 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000221 DUF276; Region: DUF276; pfam03434 521010000222 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000223 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000224 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000225 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000226 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000227 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000228 Terminase-like family; Region: Terminase_6; pfam03237 521010000229 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000230 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000231 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000232 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000233 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000234 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000235 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000236 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000237 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000238 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000240 P-loop; other site 521010000241 Magnesium ion binding site [ion binding]; other site 521010000242 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000243 Magnesium ion binding site [ion binding]; other site 521010000244 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000245 AAA domain; Region: AAA_13; pfam13166 521010000246 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000247 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 521010000248 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000249 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000250 Terminase-like family; Region: Terminase_6; pfam03237 521010000251 Acylphosphatase; Region: Acylphosphatase; cl00551 521010000252 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 521010000253 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521010000254 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 521010000255 methionine cluster; other site 521010000256 active site 521010000257 phosphorylation site [posttranslational modification] 521010000258 metal binding site [ion binding]; metal-binding site 521010000259 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 521010000260 active site 521010000261 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 521010000262 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000263 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000264 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000265 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000266 P-loop; other site 521010000267 Magnesium ion binding site [ion binding]; other site 521010000268 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000269 Magnesium ion binding site [ion binding]; other site 521010000270 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000271 Protein of unknown function (DUF1187); Region: DUF1187; cl11638 521010000272 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010000273 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010000274 peptide binding site [polypeptide binding]; other site 521010000275 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 521010000276 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 521010000277 active site 521010000278 GMP synthase; Reviewed; Region: guaA; PRK00074 521010000279 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 521010000280 AMP/PPi binding site [chemical binding]; other site 521010000281 candidate oxyanion hole; other site 521010000282 catalytic triad [active] 521010000283 potential glutamine specificity residues [chemical binding]; other site 521010000284 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 521010000285 ATP Binding subdomain [chemical binding]; other site 521010000286 Ligand Binding sites [chemical binding]; other site 521010000287 Dimerization subdomain; other site 521010000288 Lipoprotein; Region: Lipoprotein_6; pfam01441 521010000289 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 521010000290 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 521010000291 Domain of unknown function (DUF955); Region: DUF955; cl01076 521010000292 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521010000293 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521010000294 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 521010000295 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521010000296 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521010000297 active site turn [active] 521010000298 phosphorylation site [posttranslational modification] 521010000299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 521010000300 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000301 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000302 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000303 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000304 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000305 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000306 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000307 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000308 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000309 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000310 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000311 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000312 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000313 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000314 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000315 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000316 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000317 DUF276; Region: DUF276; pfam03434 521010000318 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000319 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000320 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000321 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000322 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000323 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 521010000324 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000325 ERF superfamily; Region: ERF; pfam04404 521010000326 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000327 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000328 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000330 P-loop; other site 521010000331 Magnesium ion binding site [ion binding]; other site 521010000332 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000333 Magnesium ion binding site [ion binding]; other site 521010000334 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000335 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 521010000336 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000337 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000338 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000339 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000340 active site 521010000341 catalytic residues [active] 521010000342 DNA binding site [nucleotide binding] 521010000343 Int/Topo IB signature motif; other site 521010000344 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000345 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000346 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000347 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000348 Terminase-like family; Region: Terminase_6; pfam03237 521010000349 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 521010000351 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000352 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000353 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000354 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000355 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000356 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000357 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000358 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000359 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000360 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000361 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000362 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000363 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000364 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000365 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000366 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000367 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000368 DUF276; Region: DUF276; pfam03434 521010000369 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000370 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000371 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000372 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000373 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000374 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000375 ERF superfamily; Region: ERF; pfam04404 521010000376 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000377 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000378 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000379 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000380 Magnesium ion binding site [ion binding]; other site 521010000381 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000382 membrane glycoprotein; Provisional; Region: PHA03332 521010000383 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000384 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000385 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000386 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000387 active site 521010000388 catalytic residues [active] 521010000389 DNA binding site [nucleotide binding] 521010000390 Int/Topo IB signature motif; other site 521010000391 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000392 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000393 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000394 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000395 Terminase-like family; Region: Terminase_6; pfam03237 521010000396 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 521010000398 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000399 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000400 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000401 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000402 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000403 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000404 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000405 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000406 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000407 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000408 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000409 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000410 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000411 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000412 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000413 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000414 DUF276; Region: DUF276; pfam03434 521010000415 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000416 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000417 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000418 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000419 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000420 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000421 ERF superfamily; Region: ERF; pfam04404 521010000422 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000423 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000424 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000425 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 521010000426 P-loop; other site 521010000427 Magnesium ion binding site [ion binding]; other site 521010000428 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000429 Magnesium ion binding site [ion binding]; other site 521010000430 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000431 AAA domain; Region: AAA_13; pfam13166 521010000432 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000433 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000434 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000435 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000436 active site 521010000437 Int/Topo IB signature motif; other site 521010000438 catalytic residues [active] 521010000439 DNA binding site [nucleotide binding] 521010000440 TM2 domain; Region: TM2; cl00984 521010000441 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000442 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000443 Terminase-like family; Region: Terminase_6; pfam03237 521010000444 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000445 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000446 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000447 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000448 P-loop; other site 521010000449 Magnesium ion binding site [ion binding]; other site 521010000450 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000451 Magnesium ion binding site [ion binding]; other site 521010000452 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000453 ERF superfamily; Region: ERF; pfam04404 521010000454 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 521010000455 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010000456 Borrelia burgdorferi REV protein; Region: Borrelia_REV; pfam03978 521010000457 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000458 active site 521010000459 catalytic residues [active] 521010000460 DNA binding site [nucleotide binding] 521010000461 Int/Topo IB signature motif; other site 521010000462 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000463 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000464 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000465 TM2 domain; Region: TM2; cl00984 521010000466 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000467 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000468 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000469 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000470 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000471 P-loop; other site 521010000472 Magnesium ion binding site [ion binding]; other site 521010000473 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000474 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 521010000475 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 521010000477 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 521010000478 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 521010000479 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000480 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000481 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000482 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000483 P-loop; other site 521010000484 Magnesium ion binding site [ion binding]; other site 521010000485 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000486 Magnesium ion binding site [ion binding]; other site 521010000487 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000488 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000489 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010000490 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000491 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000492 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000493 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000494 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000495 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000496 P-loop; other site 521010000497 Magnesium ion binding site [ion binding]; other site 521010000498 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000499 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000500 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000501 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521010000502 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000503 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 521010000505 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 521010000506 Probable transposase; Region: OrfB_IS605; pfam01385 521010000507 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 521010000508 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000509 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000510 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000511 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000512 Protein of unknown function (DUF541); Region: SIMPL; cl01077 521010000513 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000514 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000515 adenine deaminase; Region: ade; TIGR01178 521010000516 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521010000517 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 521010000518 active site 521010000519 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521010000520 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000521 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000522 AAA domain; Region: AAA_31; pfam13614 521010000523 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000524 P-loop; other site 521010000525 Magnesium ion binding site [ion binding]; other site 521010000526 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000527 Magnesium ion binding site [ion binding]; other site 521010000528 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000529 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000530 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000531 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 521010000532 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000533 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000534 DUF276; Region: DUF276; pfam03434 521010000535 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000536 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000537 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000538 holin, BlyA family; Region: Holin_BlyA; cl15434 521010000539 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000540 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 521010000541 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 521010000542 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000543 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000544 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000545 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000546 P-loop; other site 521010000547 Magnesium ion binding site [ion binding]; other site 521010000548 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000549 Magnesium ion binding site [ion binding]; other site 521010000550 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000551 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000552 Decorin binding protein; Region: Decorin_bind; pfam02352 521010000553 Decorin binding protein; Region: Decorin_bind; pfam02352 521010000554 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000555 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000556 Terminase-like family; Region: Terminase_6; pfam03237 521010000557 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010000558 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010000559 peptide binding site [polypeptide binding]; other site 521010000560 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000561 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000562 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000563 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000564 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000565 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000566 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000567 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000568 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000569 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000570 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000571 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000572 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000573 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000574 OMS28 porin; Region: OMS28_porin; pfam03532 521010000575 Thymidylate synthase complementing protein; Region: Thy1; cl03630 521010000576 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 521010000577 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000578 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000579 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000580 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000581 P-loop; other site 521010000582 Magnesium ion binding site [ion binding]; other site 521010000583 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000584 Magnesium ion binding site [ion binding]; other site 521010000585 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000586 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000587 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 521010000589 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000590 Right handed beta helix region; Region: Beta_helix; pfam13229 521010000591 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000592 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000593 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000594 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000595 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000596 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 521010000597 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010000598 Walker A motif; other site 521010000599 ATP binding site [chemical binding]; other site 521010000600 Walker B motif; other site 521010000601 AAA domain; Region: AAA_13; pfam13166 521010000602 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 521010000603 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 521010000604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521010000605 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 521010000606 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 521010000607 active site 521010000608 substrate binding site [chemical binding]; other site 521010000609 metal binding site [ion binding]; metal-binding site 521010000610 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 521010000611 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 521010000612 active site 521010000613 HIGH motif; other site 521010000614 dimer interface [polypeptide binding]; other site 521010000615 KMSKS motif; other site 521010000616 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 521010000617 Domain of unknown function DUF20; Region: UPF0118; pfam01594 521010000618 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521010000619 TIGR00159 family protein; Region: TIGR00159 521010000620 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 521010000621 YbbR-like protein; Region: YbbR; pfam07949 521010000622 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 521010000623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 521010000624 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 521010000625 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 521010000626 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 521010000627 dimerization interface 3.5A [polypeptide binding]; other site 521010000628 active site 521010000629 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 521010000630 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 521010000631 primosomal protein N'; Region: priA; TIGR00595 521010000632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010000633 ATP binding site [chemical binding]; other site 521010000634 putative Mg++ binding site [ion binding]; other site 521010000635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010000636 nucleotide binding region [chemical binding]; other site 521010000637 ATP-binding site [chemical binding]; other site 521010000638 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 521010000639 Sugar specificity; other site 521010000640 Pyrimidine base specificity; other site 521010000641 ATP-binding site [chemical binding]; other site 521010000642 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521010000643 active site residue [active] 521010000644 Uncharacterized conserved protein [Function unknown]; Region: COG1284 521010000645 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521010000646 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 521010000647 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521010000648 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521010000649 active site 521010000650 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent...; Region: Pyrophosphate_PFK; cd00765 521010000651 active site 521010000652 pyrophosphate binding site [ion binding]; other site 521010000653 dimerization interface [polypeptide binding]; other site 521010000654 fructose-6-phosphate binding site; other site 521010000655 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 521010000656 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 521010000657 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 521010000658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010000659 Walker A motif; other site 521010000660 ATP binding site [chemical binding]; other site 521010000661 Walker B motif; other site 521010000662 arginine finger; other site 521010000663 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 521010000664 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK13901 521010000665 RuvA N terminal domain; Region: RuvA_N; pfam01330 521010000666 Reversibly glycosylated polypeptide; Region: RGP; cl07847 521010000667 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 521010000668 Transcriptional regulator; Region: Transcrip_reg; cl00361 521010000669 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 521010000670 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 521010000671 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 521010000672 homodimer interface [polypeptide binding]; other site 521010000673 NADP binding site [chemical binding]; other site 521010000674 substrate binding site [chemical binding]; other site 521010000675 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 521010000676 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521010000677 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 521010000678 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521010000679 Catalytic site [active] 521010000680 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521010000681 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521010000682 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 521010000683 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 521010000684 SmpB-tmRNA interface; other site 521010000685 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000686 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 521010000687 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 521010000688 CAP-like domain; other site 521010000689 active site 521010000690 primary dimer interface [polypeptide binding]; other site 521010000691 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 521010000692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 521010000693 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521010000694 anchoring element; other site 521010000695 dimer interface [polypeptide binding]; other site 521010000696 ATP binding site [chemical binding]; other site 521010000697 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 521010000698 active site 521010000699 putative metal-binding site [ion binding]; other site 521010000700 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521010000701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521010000702 putative acyl-acceptor binding pocket; other site 521010000703 PPIC-type PPIASE domain; Region: Rotamase; cl08278 521010000704 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 521010000705 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 521010000706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010000707 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 521010000708 PhoU domain; Region: PhoU; pfam01895 521010000709 PhoU domain; Region: PhoU; pfam01895 521010000710 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521010000711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010000712 Walker A/P-loop; other site 521010000713 ATP binding site [chemical binding]; other site 521010000714 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521010000715 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010000716 ABC transporter signature motif; other site 521010000717 Walker B; other site 521010000718 D-loop; other site 521010000719 H-loop/switch region; other site 521010000720 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 521010000721 RNA/DNA hybrid binding site [nucleotide binding]; other site 521010000722 active site 521010000723 Protein of unknown function (DUF3276); Region: DUF3276; cl15305 521010000724 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 521010000725 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 521010000726 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 521010000727 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 521010000728 ligand binding site [chemical binding]; other site 521010000729 active site 521010000730 UGI interface [polypeptide binding]; other site 521010000731 catalytic site [active] 521010000732 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 521010000733 substrate binding site [chemical binding]; other site 521010000734 dimer interface [polypeptide binding]; other site 521010000735 catalytic triad [active] 521010000736 Phosphoglycerate kinase; Region: PGK; pfam00162 521010000737 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 521010000738 substrate binding site [chemical binding]; other site 521010000739 hinge regions; other site 521010000740 ADP binding site [chemical binding]; other site 521010000741 catalytic site [active] 521010000742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521010000743 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 521010000744 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 521010000745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000746 binding surface 521010000747 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010000748 TPR motif; other site 521010000749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521010000750 TPR motif; other site 521010000751 binding surface 521010000752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000753 TPR repeat; Region: TPR_11; pfam13414 521010000754 binding surface 521010000755 TPR motif; other site 521010000756 FOG: CBS domain [General function prediction only]; Region: COG0517 521010000757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521010000758 Transporter associated domain; Region: CorC_HlyC; cl08393 521010000759 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 521010000760 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521010000761 catalytic residues [active] 521010000762 RNA methyltransferase, RsmE family; Region: TIGR00046 521010000763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 521010000764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 521010000765 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521010000766 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 521010000767 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 521010000768 methionyl-tRNA formyltransferase; Region: fmt; TIGR00460 521010000769 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 521010000770 putative active site [active] 521010000771 substrate binding site [chemical binding]; other site 521010000772 putative cosubstrate binding site; other site 521010000773 catalytic site [active] 521010000774 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 521010000775 substrate binding site [chemical binding]; other site 521010000776 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 521010000777 active site 521010000778 catalytic residues [active] 521010000779 metal binding site [ion binding]; metal-binding site 521010000780 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521010000781 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 521010000782 active site 521010000783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521010000784 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521010000785 active site 521010000786 motif I; other site 521010000787 motif II; other site 521010000788 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521010000789 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 521010000790 Divergent PAP2 family; Region: DUF212; cl00855 521010000791 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 521010000792 RF-1 domain; Region: RF-1; cl02875 521010000793 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 521010000794 RF-1 domain; Region: RF-1; cl02875 521010000795 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 521010000796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010000797 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521010000798 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521010000799 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 521010000800 Walker A/P-loop; other site 521010000801 ATP binding site [chemical binding]; other site 521010000802 Q-loop/lid; other site 521010000803 ABC transporter signature motif; other site 521010000804 Walker B; other site 521010000805 D-loop; other site 521010000806 H-loop/switch region; other site 521010000807 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521010000808 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521010000809 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 521010000810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521010000811 catalytic residue [active] 521010000812 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 521010000813 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 521010000814 active site 521010000815 trimerization site [polypeptide binding]; other site 521010000816 Mg chelatase-related protein; Region: TIGR00368 521010000817 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 521010000818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010000819 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 521010000820 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 521010000821 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521010000822 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 521010000823 NAD binding site [chemical binding]; other site 521010000824 dimer interface [polypeptide binding]; other site 521010000825 substrate binding site [chemical binding]; other site 521010000826 GTP-binding protein LepA; Provisional; Region: PRK05433 521010000827 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 521010000828 Switch I region; other site 521010000829 G2 box; other site 521010000830 putative GEF interaction site [polypeptide binding]; other site 521010000831 G3 box; other site 521010000832 Switch II region; other site 521010000833 GTP/Mg2+ binding site [chemical binding]; other site 521010000834 G4 box; other site 521010000835 G5 box; other site 521010000836 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 521010000837 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 521010000838 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 521010000839 V-type ATP synthase subunit K; Validated; Region: PRK06649 521010000840 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010000841 ATP synthase subunit D; Region: ATP-synt_D; cl00613 521010000842 V-type ATP synthase subunit B; Provisional; Region: PRK02118 521010000843 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 521010000844 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 521010000845 Walker A motif homologous position; other site 521010000846 Walker B motif; other site 521010000847 V-type ATP synthase subunit A; Provisional; Region: PRK04192 521010000848 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 521010000849 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 521010000850 Walker A motif/ATP binding site; other site 521010000851 Walker B motif; other site 521010000852 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 521010000853 MutS2 family protein; Region: mutS2; TIGR01069 521010000854 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 521010000855 Walker A/P-loop; other site 521010000856 ATP binding site [chemical binding]; other site 521010000857 Q-loop/lid; other site 521010000858 ABC transporter signature motif; other site 521010000859 Walker B; other site 521010000860 D-loop; other site 521010000861 H-loop/switch region; other site 521010000862 Smr domain; Region: Smr; cl02619 521010000863 ribosome small subunit-dependent GTPase A; Region: TIGR00157 521010000864 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 521010000865 GTPase/Zn-binding domain interface [polypeptide binding]; other site 521010000866 GTP/Mg2+ binding site [chemical binding]; other site 521010000867 G4 box; other site 521010000868 G5 box; other site 521010000869 G1 box; other site 521010000870 Switch I region; other site 521010000871 G2 box; other site 521010000872 G3 box; other site 521010000873 Switch II region; other site 521010000874 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 521010000875 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 521010000876 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 521010000877 putative dimer interface [polypeptide binding]; other site 521010000878 putative anticodon binding site; other site 521010000879 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 521010000880 homodimer interface [polypeptide binding]; other site 521010000881 motif 1; other site 521010000882 motif 2; other site 521010000883 active site 521010000884 motif 3; other site 521010000885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521010000886 active site 521010000887 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 521010000888 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 521010000889 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521010000890 protein binding site [polypeptide binding]; other site 521010000891 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521010000892 protein binding site [polypeptide binding]; other site 521010000893 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 521010000894 active site 521010000895 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 521010000896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521010000897 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 521010000898 putative RNA binding site [nucleotide binding]; other site 521010000899 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 521010000900 SurA N-terminal domain; Region: SurA_N_3; cl07813 521010000901 PPIC-type PPIASE domain; Region: Rotamase; cl08278 521010000902 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 521010000903 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 521010000904 dimer interface [polypeptide binding]; other site 521010000905 active site 521010000906 replicative DNA helicase; Region: DnaB; TIGR00665 521010000907 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 521010000908 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 521010000909 Walker A motif; other site 521010000910 ATP binding site [chemical binding]; other site 521010000911 Walker B motif; other site 521010000912 DNA binding loops [nucleotide binding] 521010000913 ribosomal protein L9; Region: L9; TIGR00158 521010000914 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 521010000915 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 521010000916 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 521010000917 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521010000918 dimer interface [polypeptide binding]; other site 521010000919 ssDNA binding site [nucleotide binding]; other site 521010000920 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521010000921 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 521010000922 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521010000923 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 521010000924 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521010000925 active site turn [active] 521010000926 phosphorylation site [posttranslational modification] 521010000927 Haemolysin-III related; Region: HlyIII; cl03831 521010000928 RIP metalloprotease RseP; Region: TIGR00054 521010000929 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 521010000930 active site 521010000931 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521010000932 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521010000933 protein binding site [polypeptide binding]; other site 521010000934 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521010000935 putative substrate binding region [chemical binding]; other site 521010000936 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 521010000937 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 521010000938 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 521010000939 catalytic residue [active] 521010000940 putative FPP diphosphate binding site; other site 521010000941 putative FPP binding hydrophobic cleft; other site 521010000942 dimer interface [polypeptide binding]; other site 521010000943 putative IPP diphosphate binding site; other site 521010000944 ribosome recycling factor; Reviewed; Region: frr; PRK00083 521010000945 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 521010000946 hinge region; other site 521010000947 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 521010000948 Elongation factor TS; Region: EF_TS; pfam00889 521010000949 Elongation factor TS; Region: EF_TS; pfam00889 521010000950 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 521010000951 rRNA interaction site [nucleotide binding]; other site 521010000952 S8 interaction site; other site 521010000953 putative laminin-1 binding site; other site 521010000954 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 521010000955 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 521010000956 RNA binding site [nucleotide binding]; other site 521010000957 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521010000958 RNA binding site [nucleotide binding]; other site 521010000959 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521010000960 RNA binding site [nucleotide binding]; other site 521010000961 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 521010000962 RNA binding site [nucleotide binding]; other site 521010000963 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521010000964 cytidylate kinase; Region: cmk; TIGR00017 521010000965 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521010000966 CMP-binding site; other site 521010000967 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 521010000968 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 521010000969 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 521010000970 active site 521010000971 ScpA/B protein; Region: ScpA_ScpB; cl00598 521010000972 recombinase A; Provisional; Region: recA; PRK09354 521010000973 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 521010000974 hexamer interface [polypeptide binding]; other site 521010000975 Walker A motif; other site 521010000976 ATP binding site [chemical binding]; other site 521010000977 Walker B motif; other site 521010000978 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 521010000979 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 521010000980 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 521010000981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000982 binding surface 521010000983 TPR motif; other site 521010000984 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010000985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000986 TPR motif; other site 521010000987 binding surface 521010000988 histidyl-tRNA synthetase; Region: hisS; TIGR00442 521010000989 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 521010000990 dimer interface [polypeptide binding]; other site 521010000991 motif 1; other site 521010000992 active site 521010000993 motif 2; other site 521010000994 motif 3; other site 521010000995 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 521010000996 anticodon binding site; other site 521010000997 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 521010000998 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521010000999 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521010001000 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 521010001001 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 521010001002 AMP-binding enzyme; Region: AMP-binding; cl15778 521010001003 AMP-binding enzyme; Region: AMP-binding; cl15778 521010001004 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521010001005 Protein export membrane protein; Region: SecD_SecF; cl14618 521010001006 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 521010001007 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 521010001008 Outer membrane efflux protein; Region: OEP; pfam02321 521010001009 NMT1-like family; Region: NMT1_2; cl15260 521010001010 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 521010001011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001012 dimer interface [polypeptide binding]; other site 521010001013 conserved gate region; other site 521010001014 putative PBP binding loops; other site 521010001015 ABC-ATPase subunit interface; other site 521010001016 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 521010001017 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 521010001018 Walker A/P-loop; other site 521010001019 ATP binding site [chemical binding]; other site 521010001020 Q-loop/lid; other site 521010001021 ABC transporter signature motif; other site 521010001022 Walker B; other site 521010001023 D-loop; other site 521010001024 H-loop/switch region; other site 521010001025 flagellin; Provisional; Region: PRK12803 521010001026 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521010001027 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 521010001028 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 521010001029 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 521010001030 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 521010001031 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 521010001032 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 521010001033 active site 521010001034 dimer interface [polypeptide binding]; other site 521010001035 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 521010001036 active site 521010001037 trimer interface [polypeptide binding]; other site 521010001038 allosteric site; other site 521010001039 active site lid [active] 521010001040 hexamer (dimer of trimers) interface [polypeptide binding]; other site 521010001041 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 521010001042 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 521010001043 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 521010001044 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 521010001045 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 521010001046 SEC-C motif; Region: SEC-C; pfam02810 521010001047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 521010001048 alanine racemase; Region: alr; TIGR00492 521010001049 active site 521010001050 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521010001051 dimer interface [polypeptide binding]; other site 521010001052 substrate binding site [chemical binding]; other site 521010001053 catalytic residues [active] 521010001054 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 521010001055 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 521010001056 Uncharacterized conserved protein [Function unknown]; Region: COG1306 521010001057 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 521010001058 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 521010001059 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521010001060 ligand binding site [chemical binding]; other site 521010001061 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 521010001062 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 521010001063 rRNA binding site [nucleotide binding]; other site 521010001064 predicted 30S ribosome binding site; other site 521010001065 Oxygen tolerance; Region: BatD; pfam13584 521010001066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521010001067 TPR motif; other site 521010001068 binding surface 521010001069 Bacterial SH3 domain; Region: SH3_3; cl02551 521010001070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001071 binding surface 521010001072 TPR motif; other site 521010001073 TPR repeat; Region: TPR_11; pfam13414 521010001074 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521010001075 metal ion-dependent adhesion site (MIDAS); other site 521010001076 Aerotolerance regulator N-terminal; Region: BatA; cl06567 521010001077 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 521010001078 metal ion-dependent adhesion site (MIDAS); other site 521010001079 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521010001080 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521010001081 MoxR-like ATPases [General function prediction only]; Region: COG0714 521010001082 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010001084 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 521010001085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521010001086 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 521010001087 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 521010001088 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 521010001089 trmE is a tRNA modification GTPase; Region: trmE; cd04164 521010001090 G1 box; other site 521010001091 GTP/Mg2+ binding site [chemical binding]; other site 521010001092 Switch I region; other site 521010001093 G2 box; other site 521010001094 Switch II region; other site 521010001095 G3 box; other site 521010001096 G4 box; other site 521010001097 G5 box; other site 521010001098 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 521010001099 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 521010001100 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 521010001101 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 521010001102 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 521010001103 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521010001104 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 521010001105 FliW protein; Region: FliW; cl00740 521010001106 Global regulator protein family; Region: CsrA; cl00670 521010001107 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 521010001108 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 521010001109 ribosomal protein L20; Region: rpl20; CHL00068 521010001110 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 521010001111 23S rRNA binding site [nucleotide binding]; other site 521010001112 L21 binding site [polypeptide binding]; other site 521010001113 L13 binding site [polypeptide binding]; other site 521010001114 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 521010001115 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 521010001116 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 521010001117 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 521010001118 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 521010001119 active site 521010001120 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 521010001121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001122 binding surface 521010001123 TPR motif; other site 521010001124 TPR repeat; Region: TPR_11; pfam13414 521010001125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521010001126 TPR repeat; Region: TPR_11; pfam13414 521010001127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001128 binding surface 521010001129 TPR motif; other site 521010001130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001131 binding surface 521010001132 TPR motif; other site 521010001133 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001134 peptide chain release factor 1; Validated; Region: prfA; PRK00591 521010001135 RF-1 domain; Region: RF-1; cl02875 521010001136 RF-1 domain; Region: RF-1; cl02875 521010001137 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 521010001138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521010001139 S-adenosylmethionine binding site [chemical binding]; other site 521010001140 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 521010001141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521010001142 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 521010001143 synthetase active site [active] 521010001144 NTP binding site [chemical binding]; other site 521010001145 metal binding site [ion binding]; metal-binding site 521010001146 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 521010001147 D-alanyl-alanine synthetase A; Provisional; Region: PRK14570 521010001148 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521010001149 ATP-grasp domain; Region: ATP-grasp_4; cl03087 521010001150 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 521010001151 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521010001152 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521010001153 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521010001154 Domain of unknown function DUF21; Region: DUF21; pfam01595 521010001155 FOG: CBS domain [General function prediction only]; Region: COG0517 521010001156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521010001157 Transporter associated domain; Region: CorC_HlyC; cl08393 521010001158 HflK protein; Region: hflK; TIGR01933 521010001159 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 521010001160 HflC protein; Region: hflC; TIGR01932 521010001161 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 521010001162 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 521010001163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010001164 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521010001165 active site 521010001166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521010001167 binding surface 521010001168 TPR motif; other site 521010001169 TPR repeat; Region: TPR_11; pfam13414 521010001170 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 521010001171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001172 TPR motif; other site 521010001173 binding surface 521010001174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001175 binding surface 521010001176 TPR repeat; Region: TPR_11; pfam13414 521010001177 TPR motif; other site 521010001178 TPR repeat; Region: TPR_11; pfam13414 521010001179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001180 binding surface 521010001181 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001182 TPR motif; other site 521010001183 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 521010001184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001185 TPR motif; other site 521010001186 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001187 binding surface 521010001188 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 521010001189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 521010001190 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 521010001191 ATP binding site [chemical binding]; other site 521010001192 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 521010001193 elongation factor P; Validated; Region: PRK00529 521010001194 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 521010001195 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 521010001196 RNA binding site [nucleotide binding]; other site 521010001197 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 521010001198 RNA binding site [nucleotide binding]; other site 521010001199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 521010001200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001201 dimer interface [polypeptide binding]; other site 521010001202 conserved gate region; other site 521010001203 putative PBP binding loops; other site 521010001204 ABC-ATPase subunit interface; other site 521010001205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001206 dimer interface [polypeptide binding]; other site 521010001207 conserved gate region; other site 521010001208 putative PBP binding loops; other site 521010001209 ABC-ATPase subunit interface; other site 521010001210 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14273 521010001211 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 521010001212 Walker A/P-loop; other site 521010001213 ATP binding site [chemical binding]; other site 521010001214 Q-loop/lid; other site 521010001215 ABC transporter signature motif; other site 521010001216 Walker B; other site 521010001217 D-loop; other site 521010001218 H-loop/switch region; other site 521010001219 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 521010001220 ZIP Zinc transporter; Region: Zip; pfam02535 521010001221 alanyl-tRNA synthetase; Provisional; Region: PRK01584 521010001222 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 521010001223 motif 1; other site 521010001224 active site 521010001225 motif 2; other site 521010001226 motif 3; other site 521010001227 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 521010001228 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 521010001229 Deoxyhypusine synthase; Region: DS; cl00826 521010001230 FliG C-terminal domain; Region: FliG_C; pfam01706 521010001231 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 521010001232 putative active site [active] 521010001233 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521010001234 active site 521010001235 FMN binding site [chemical binding]; other site 521010001236 catalytic residues [active] 521010001237 substrate binding site [chemical binding]; other site 521010001238 seryl-tRNA synthetase; Region: serS; TIGR00414 521010001239 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 521010001240 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 521010001241 dimer interface [polypeptide binding]; other site 521010001242 active site 521010001243 motif 1; other site 521010001244 motif 2; other site 521010001245 motif 3; other site 521010001246 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 521010001247 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521010001248 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521010001249 Peptidase M16C associated; Region: M16C_assoc; pfam08367 521010001250 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521010001251 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 521010001252 transcription termination factor Rho; Region: rho; TIGR00767 521010001253 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 521010001254 RNA binding site [nucleotide binding]; other site 521010001255 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 521010001256 multimer interface [polypeptide binding]; other site 521010001257 Walker A motif; other site 521010001258 ATP binding site [chemical binding]; other site 521010001259 Walker B motif; other site 521010001260 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 521010001261 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 521010001262 IHF dimer interface [polypeptide binding]; other site 521010001263 IHF - DNA interface [nucleotide binding]; other site 521010001264 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 521010001265 GTP-binding protein YchF; Reviewed; Region: PRK09601 521010001266 YchF GTPase; Region: YchF; cd01900 521010001267 G1 box; other site 521010001268 GTP/Mg2+ binding site [chemical binding]; other site 521010001269 Switch I region; other site 521010001270 G2 box; other site 521010001271 Switch II region; other site 521010001272 G3 box; other site 521010001273 G4 box; other site 521010001274 G5 box; other site 521010001275 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 521010001276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521010001277 TPR motif; other site 521010001278 binding surface 521010001279 Uncharacterized conserved protein [Function unknown]; Region: COG3391 521010001280 Uncharacterized conserved protein [Function unknown]; Region: COG3391 521010001281 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521010001282 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 521010001283 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 521010001284 putative active site [active] 521010001285 catalytic triad [active] 521010001286 putative dimer interface [polypeptide binding]; other site 521010001287 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 521010001288 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 521010001289 Substrate-binding site [chemical binding]; other site 521010001290 Substrate specificity [chemical binding]; other site 521010001291 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 521010001292 amphipathic channel; other site 521010001293 Asn-Pro-Ala signature motifs; other site 521010001294 glycerol kinase; Provisional; Region: glpK; PRK00047 521010001295 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 521010001296 N- and C-terminal domain interface [polypeptide binding]; other site 521010001297 active site 521010001298 MgATP binding site [chemical binding]; other site 521010001299 catalytic site [active] 521010001300 metal binding site [ion binding]; metal-binding site 521010001301 glycerol binding site [chemical binding]; other site 521010001302 homotetramer interface [polypeptide binding]; other site 521010001303 homodimer interface [polypeptide binding]; other site 521010001304 FBP binding site [chemical binding]; other site 521010001305 protein IIAGlc interface [polypeptide binding]; other site 521010001306 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 521010001307 Protein of unknown function (DUF327); Region: DUF327; cl00753 521010001308 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 521010001309 Peptidase family M23; Region: Peptidase_M23; pfam01551 521010001310 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 521010001311 active site 521010001312 dimerization interface [polypeptide binding]; other site 521010001313 oligoendopeptidase F; Region: pepF; TIGR00181 521010001314 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 521010001315 active site 521010001316 Zn binding site [ion binding]; other site 521010001317 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 521010001318 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 521010001319 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 521010001320 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 521010001321 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521010001322 HIGH motif; other site 521010001323 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521010001324 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521010001325 active site 521010001326 KMSKS motif; other site 521010001327 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 521010001328 tRNA binding surface [nucleotide binding]; other site 521010001329 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 521010001330 Found in ATP-dependent protease La (LON); Region: LON; smart00464 521010001331 ATP-dependent protease La; Region: lon; TIGR00763 521010001332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001333 Walker A motif; other site 521010001334 ATP binding site [chemical binding]; other site 521010001335 Walker B motif; other site 521010001336 arginine finger; other site 521010001337 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 521010001338 DHH family; Region: DHH; pfam01368 521010001339 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 521010001340 DHHA1 domain; Region: DHHA1; pfam02272 521010001341 Peptidase family M23; Region: Peptidase_M23; pfam01551 521010001342 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 521010001343 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 521010001344 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001345 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 521010001346 Bacitracin resistance protein BacA; Region: BacA; cl00858 521010001347 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 521010001348 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521010001349 catalytic residue [active] 521010001350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001351 binding surface 521010001352 TPR motif; other site 521010001353 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 521010001354 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521010001355 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010001356 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010001357 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521010001358 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521010001359 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 521010001360 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 521010001361 ATP binding site [chemical binding]; other site 521010001362 profilin binding site; other site 521010001363 Uncharacterized conserved protein [Function unknown]; Region: COG1315 521010001364 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521010001365 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001366 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521010001367 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 521010001368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001369 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001370 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 521010001371 FHIPEP family; Region: FHIPEP; pfam00771 521010001372 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 521010001373 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 521010001374 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 521010001375 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 521010001376 FliP family; Region: FliP; cl00593 521010001377 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 521010001378 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 521010001379 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 521010001380 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 521010001381 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 521010001382 flagellar motor protein MotB; Validated; Region: motB; PRK06667 521010001383 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 521010001384 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521010001385 ligand binding site [chemical binding]; other site 521010001386 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 521010001387 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 521010001388 Flagellar protein (FlbD); Region: FlbD; cl00683 521010001389 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 521010001390 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 521010001391 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 521010001392 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 521010001393 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 521010001394 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 521010001395 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 521010001396 ATPase FliI/YscN family; Region: fliI_yscN; TIGR01026 521010001397 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 521010001398 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 521010001399 Walker A motif/ATP binding site; other site 521010001400 Walker B motif; other site 521010001401 flagellar assembly protein H; Validated; Region: fliH; PRK06669 521010001402 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 521010001403 Flagellar assembly protein FliH; Region: FliH; pfam02108 521010001404 flagellar motor switch protein FliG; Region: fliG; TIGR00207 521010001405 FliG C-terminal domain; Region: FliG_C; pfam01706 521010001406 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 521010001407 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 521010001408 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 521010001409 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 521010001410 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 521010001411 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 521010001412 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 521010001413 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622 521010001414 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 521010001415 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 521010001416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001417 Walker A motif; other site 521010001418 ATP binding site [chemical binding]; other site 521010001419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001420 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 521010001421 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 521010001422 active site 521010001423 HslU subunit interaction site [polypeptide binding]; other site 521010001424 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 521010001425 TPR repeat; Region: TPR_11; pfam13414 521010001426 cell division protein FtsZ; Validated; Region: PRK09330 521010001427 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 521010001428 nucleotide binding site [chemical binding]; other site 521010001429 SulA interaction site; other site 521010001430 cell division protein FtsA; Region: ftsA; TIGR01174 521010001431 Cell division protein FtsA; Region: FtsA; cl11496 521010001432 Cell division protein FtsA; Region: FtsA; cl11496 521010001433 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 521010001434 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 521010001435 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521010001436 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 521010001437 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 521010001438 Mg++ binding site [ion binding]; other site 521010001439 putative catalytic motif [active] 521010001440 putative substrate binding site [chemical binding]; other site 521010001441 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521010001442 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 521010001443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521010001444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521010001445 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 521010001446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010001447 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 521010001448 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 521010001449 putative CheA interaction surface; other site 521010001450 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 521010001451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010001452 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521010001453 substrate binding pocket [chemical binding]; other site 521010001454 chain length determination region; other site 521010001455 substrate-Mg2+ binding site; other site 521010001456 catalytic residues [active] 521010001457 aspartate-rich region 1; other site 521010001458 active site lid residues [active] 521010001459 aspartate-rich region 2; other site 521010001460 TPR repeat; Region: TPR_11; pfam13414 521010001461 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 521010001462 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521010001463 TM-ABC transporter signature motif; other site 521010001464 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 521010001465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001466 Walker A/P-loop; other site 521010001467 ATP binding site [chemical binding]; other site 521010001468 Q-loop/lid; other site 521010001469 ABC transporter signature motif; other site 521010001470 Walker B; other site 521010001471 D-loop; other site 521010001472 H-loop/switch region; other site 521010001473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001474 ABC transporter signature motif; other site 521010001475 Walker B; other site 521010001476 D-loop; other site 521010001477 H-loop/switch region; other site 521010001478 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521010001479 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521010001480 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 521010001481 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001482 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521010001483 metal ion-dependent adhesion site (MIDAS); other site 521010001484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001485 binding surface 521010001486 TPR motif; other site 521010001487 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 521010001488 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010001489 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010001490 peptide binding site [polypeptide binding]; other site 521010001491 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010001492 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010001493 peptide binding site [polypeptide binding]; other site 521010001494 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010001495 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010001496 peptide binding site [polypeptide binding]; other site 521010001497 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 521010001498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001499 dimer interface [polypeptide binding]; other site 521010001500 conserved gate region; other site 521010001501 putative PBP binding loops; other site 521010001502 ABC-ATPase subunit interface; other site 521010001503 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 521010001504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001505 dimer interface [polypeptide binding]; other site 521010001506 conserved gate region; other site 521010001507 putative PBP binding loops; other site 521010001508 ABC-ATPase subunit interface; other site 521010001509 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 521010001510 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 521010001511 Walker A/P-loop; other site 521010001512 ATP binding site [chemical binding]; other site 521010001513 Q-loop/lid; other site 521010001514 ABC transporter signature motif; other site 521010001515 Walker B; other site 521010001516 D-loop; other site 521010001517 H-loop/switch region; other site 521010001518 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521010001519 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 521010001520 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 521010001521 Walker A/P-loop; other site 521010001522 ATP binding site [chemical binding]; other site 521010001523 Q-loop/lid; other site 521010001524 ABC transporter signature motif; other site 521010001525 Walker B; other site 521010001526 D-loop; other site 521010001527 H-loop/switch region; other site 521010001528 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521010001529 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 521010001530 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 521010001531 enolase; Provisional; Region: eno; PRK00077 521010001532 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 521010001533 dimer interface [polypeptide binding]; other site 521010001534 metal binding site [ion binding]; metal-binding site 521010001535 substrate binding pocket [chemical binding]; other site 521010001536 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 521010001537 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 521010001538 23S rRNA interface [nucleotide binding]; other site 521010001539 L3 interface [polypeptide binding]; other site 521010001540 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521010001541 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 521010001542 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 521010001543 GatB domain; Region: GatB_Yqey; cl11497 521010001544 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 521010001545 Amidase; Region: Amidase; cl11426 521010001546 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 521010001547 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 521010001548 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001549 Family description; Region: UvrD_C_2; cl15862 521010001550 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 521010001551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 521010001552 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 521010001553 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 521010001554 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 521010001555 Domain of unknown function (DUF814); Region: DUF814; pfam05670 521010001556 pyruvate kinase; Region: pyruv_kin; TIGR01064 521010001557 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 521010001558 domain interfaces; other site 521010001559 active site 521010001560 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 521010001561 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 521010001562 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 521010001563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 521010001564 RNA methyltransferase, RsmE family; Region: TIGR00046 521010001565 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 521010001566 C-terminal peptidase (prc); Region: prc; TIGR00225 521010001567 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 521010001568 protein binding site [polypeptide binding]; other site 521010001569 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 521010001570 Catalytic dyad [active] 521010001571 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521010001572 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 521010001573 P-loop; other site 521010001574 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521010001575 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 521010001576 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521010001577 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 521010001578 active site 521010001579 dimer interfaces [polypeptide binding]; other site 521010001580 catalytic residues [active] 521010001581 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 521010001582 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 521010001583 oligomer interface [polypeptide binding]; other site 521010001584 putative active site [active] 521010001585 metal binding site [ion binding]; metal-binding site 521010001586 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 521010001587 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 521010001588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521010001589 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 521010001590 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521010001591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001592 Walker A motif; other site 521010001593 ATP binding site [chemical binding]; other site 521010001594 Walker B motif; other site 521010001595 arginine finger; other site 521010001596 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001597 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 521010001598 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 521010001599 active site 521010001600 HIGH motif; other site 521010001601 dimer interface [polypeptide binding]; other site 521010001602 KMSKS motif; other site 521010001603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 521010001604 glycyl-tRNA synthetase; Provisional; Region: PRK04173 521010001605 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 521010001606 dimer interface [polypeptide binding]; other site 521010001607 motif 1; other site 521010001608 active site 521010001609 motif 2; other site 521010001610 motif 3; other site 521010001611 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 521010001612 anticodon binding site; other site 521010001613 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 521010001614 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521010001615 active site 521010001616 HIGH motif; other site 521010001617 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521010001618 active site 521010001619 KMSKS motif; other site 521010001620 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 521010001621 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521010001622 Zn2+ binding site [ion binding]; other site 521010001623 Mg2+ binding site [ion binding]; other site 521010001624 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521010001625 S-adenosylmethionine synthetase; Region: metK; TIGR01034 521010001626 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 521010001627 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 521010001628 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 521010001629 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 521010001630 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 521010001631 HIT family signature motif; other site 521010001632 catalytic residue [active] 521010001633 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 521010001634 MgtE intracellular N domain; Region: MgtE_N; cl15244 521010001635 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 521010001636 Divalent cation transporter; Region: MgtE; cl00786 521010001637 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 521010001638 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 521010001639 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521010001640 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521010001641 ligand binding site [chemical binding]; other site 521010001642 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521010001643 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521010001644 ligand binding site [chemical binding]; other site 521010001645 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521010001646 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521010001647 ligand binding site [chemical binding]; other site 521010001648 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 521010001649 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 521010001650 S17 interaction site [polypeptide binding]; other site 521010001651 S8 interaction site; other site 521010001652 16S rRNA interaction site [nucleotide binding]; other site 521010001653 streptomycin interaction site [chemical binding]; other site 521010001654 23S rRNA interaction site [nucleotide binding]; other site 521010001655 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 521010001656 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 521010001657 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 521010001658 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 521010001659 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 521010001660 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 521010001661 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 521010001662 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521010001663 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 521010001664 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521010001665 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 521010001666 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 521010001667 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 521010001668 DNA binding site [nucleotide binding] 521010001669 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 521010001670 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 521010001671 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 521010001672 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 521010001673 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521010001674 RPB12 interaction site [polypeptide binding]; other site 521010001675 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521010001676 RPB10 interaction site [polypeptide binding]; other site 521010001677 RPB1 interaction site [polypeptide binding]; other site 521010001678 RPB11 interaction site [polypeptide binding]; other site 521010001679 RPB3 interaction site [polypeptide binding]; other site 521010001680 RPB12 interaction site [polypeptide binding]; other site 521010001681 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 521010001682 core dimer interface [polypeptide binding]; other site 521010001683 peripheral dimer interface [polypeptide binding]; other site 521010001684 L10 interface [polypeptide binding]; other site 521010001685 L11 interface [polypeptide binding]; other site 521010001686 putative EF-Tu interaction site [polypeptide binding]; other site 521010001687 putative EF-G interaction site [polypeptide binding]; other site 521010001688 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 521010001689 23S rRNA interface [nucleotide binding]; other site 521010001690 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 521010001691 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 521010001692 mRNA/rRNA interface [nucleotide binding]; other site 521010001693 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 521010001694 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 521010001695 23S rRNA interface [nucleotide binding]; other site 521010001696 L7/L12 interface [polypeptide binding]; other site 521010001697 putative thiostrepton binding site; other site 521010001698 L25 interface [polypeptide binding]; other site 521010001699 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 521010001700 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 521010001701 putative homodimer interface [polypeptide binding]; other site 521010001702 KOW motif; Region: KOW; cl00354 521010001703 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 521010001704 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521010001705 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521010001706 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 521010001707 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 521010001708 prolyl-tRNA synthetase; Provisional; Region: PRK08661 521010001709 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 521010001710 dimer interface [polypeptide binding]; other site 521010001711 motif 1; other site 521010001712 active site 521010001713 motif 2; other site 521010001714 motif 3; other site 521010001715 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 521010001716 anticodon binding site; other site 521010001717 zinc-binding site [ion binding]; other site 521010001718 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 521010001719 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010001720 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010001721 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 521010001722 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 521010001723 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521010001724 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 521010001725 active site 521010001726 phosphorylation site [posttranslational modification] 521010001727 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 521010001728 active site 521010001729 P-loop; other site 521010001730 phosphorylation site [posttranslational modification] 521010001731 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521010001732 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 521010001733 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 521010001734 active site 521010001735 substrate binding site [chemical binding]; other site 521010001736 Mg2+ binding site [ion binding]; other site 521010001737 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 521010001738 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 521010001739 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 521010001740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010001741 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 521010001742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010001743 active site 521010001744 phosphorylation site [posttranslational modification] 521010001745 intermolecular recognition site; other site 521010001746 CheB methylesterase; Region: CheB_methylest; pfam01339 521010001747 TraB family; Region: TraB; cl12050 521010001748 adenylate kinase; Provisional; Region: PRK14526 521010001749 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 521010001750 AMP-binding site [chemical binding]; other site 521010001751 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 521010001752 Response regulator receiver domain; Region: Response_reg; pfam00072 521010001753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010001754 active site 521010001755 phosphorylation site [posttranslational modification] 521010001756 intermolecular recognition site; other site 521010001757 dimerization interface [polypeptide binding]; other site 521010001758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521010001759 metal binding site [ion binding]; metal-binding site 521010001760 active site 521010001761 I-site; other site 521010001762 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521010001763 substrate binding pocket [chemical binding]; other site 521010001764 membrane-bound complex binding site; other site 521010001765 hinge residues; other site 521010001766 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 521010001767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 521010001768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010001769 ATP binding site [chemical binding]; other site 521010001770 Mg2+ binding site [ion binding]; other site 521010001771 G-X-G motif; other site 521010001772 Response regulator receiver domain; Region: Response_reg; pfam00072 521010001773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010001774 active site 521010001775 phosphorylation site [posttranslational modification] 521010001776 intermolecular recognition site; other site 521010001777 dimerization interface [polypeptide binding]; other site 521010001778 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521010001779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521010001780 active site 521010001781 motif I; other site 521010001782 motif II; other site 521010001783 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521010001784 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 521010001785 active site 521010001786 DNA binding site [nucleotide binding] 521010001787 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 521010001788 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 521010001789 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 521010001790 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 521010001791 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 521010001792 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010001793 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010001794 P-loop; other site 521010001795 Magnesium ion binding site [ion binding]; other site 521010001796 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010001797 Magnesium ion binding site [ion binding]; other site 521010001798 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001799 ParB-like partition proteins; Region: parB_part; TIGR00180 521010001800 ParB-like nuclease domain; Region: ParBc; cl02129 521010001801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 521010001802 DNA gyrase, A subunit; Region: gyrA; TIGR01063 521010001803 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 521010001804 CAP-like domain; other site 521010001805 active site 521010001806 primary dimer interface [polypeptide binding]; other site 521010001807 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001808 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001809 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001810 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001811 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001812 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001813 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 521010001814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010001815 ATP binding site [chemical binding]; other site 521010001816 Mg2+ binding site [ion binding]; other site 521010001817 G-X-G motif; other site 521010001818 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521010001819 anchoring element; other site 521010001820 dimer interface [polypeptide binding]; other site 521010001821 ATP binding site [chemical binding]; other site 521010001822 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 521010001823 active site 521010001824 putative metal-binding site [ion binding]; other site 521010001825 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521010001826 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 521010001827 DnaA N-terminal domain; Region: DnaA_N; pfam11638 521010001828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001829 Walker A motif; other site 521010001830 ATP binding site [chemical binding]; other site 521010001831 Walker B motif; other site 521010001832 arginine finger; other site 521010001833 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 521010001834 DnaA box-binding interface [nucleotide binding]; other site 521010001835 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 521010001836 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521010001837 putative DNA binding surface [nucleotide binding]; other site 521010001838 dimer interface [polypeptide binding]; other site 521010001839 beta-clamp/clamp loader binding surface; other site 521010001840 beta-clamp/translesion DNA polymerase binding surface; other site 521010001841 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 521010001842 Ribonuclease P; Region: Ribonuclease_P; cl00457 521010001843 membrane protein insertase; Provisional; Region: PRK01318 521010001844 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 521010001845 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 521010001846 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 521010001847 G-X-X-G motif; other site 521010001848 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 521010001849 RxxxH motif; other site 521010001850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521010001851 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 521010001852 putative NAD(P) binding site [chemical binding]; other site 521010001853 active site 521010001854 putative substrate binding site [chemical binding]; other site 521010001855 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 521010001856 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 521010001857 active site 521010001858 intersubunit interface [polypeptide binding]; other site 521010001859 zinc binding site [ion binding]; other site 521010001860 Na+ binding site [ion binding]; other site 521010001861 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 521010001862 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 521010001863 dimer interface [polypeptide binding]; other site 521010001864 anticodon binding site; other site 521010001865 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 521010001866 homodimer interface [polypeptide binding]; other site 521010001867 motif 1; other site 521010001868 active site 521010001869 motif 2; other site 521010001870 GAD domain; Region: GAD; pfam02938 521010001871 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 521010001872 active site 521010001873 motif 3; other site 521010001874 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 521010001875 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 521010001876 Sexual stage antigen s48/45 domain; Region: s48_45; cl15295 521010001877 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521010001878 active site 521010001879 phosphorylation site [posttranslational modification] 521010001880 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 521010001881 active site 521010001882 regulatory protein interface [polypeptide binding]; other site 521010001883 regulatory phosphorylation site [posttranslational modification]; other site 521010001884 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 521010001885 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 521010001886 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 521010001887 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 521010001888 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 521010001889 Chromate transporter; Region: Chromate_transp; pfam02417 521010001890 Chromate transporter; Region: Chromate_transp; pfam02417 521010001891 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521010001892 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521010001893 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 521010001894 putative ADP-binding pocket [chemical binding]; other site 521010001895 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 521010001896 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 521010001897 GIY-YIG motif/motif A; other site 521010001898 active site 521010001899 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14670 521010001900 catalytic site [active] 521010001901 putative DNA binding site [nucleotide binding]; other site 521010001902 metal binding site [ion binding]; metal-binding site 521010001903 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 521010001904 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 521010001905 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 521010001906 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001908 binding surface 521010001909 TPR motif; other site 521010001910 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647 521010001911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001912 Walker A motif; other site 521010001913 ATP binding site [chemical binding]; other site 521010001914 Walker B motif; other site 521010001915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010001916 arginine finger; other site 521010001917 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 521010001918 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 521010001919 active site 521010001920 multimer interface [polypeptide binding]; other site 521010001921 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 521010001922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 521010001923 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 521010001924 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 521010001925 Walker A/P-loop; other site 521010001926 ATP binding site [chemical binding]; other site 521010001927 Q-loop/lid; other site 521010001928 ABC transporter signature motif; other site 521010001929 Walker B; other site 521010001930 D-loop; other site 521010001931 H-loop/switch region; other site 521010001932 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 521010001933 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 521010001934 Uncharacterized conserved protein [Function unknown]; Region: COG0327 521010001935 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 521010001936 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 521010001937 lipoprotein signal peptidase; Provisional; Region: PRK14787 521010001938 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521010001939 active site 521010001940 metal binding site [ion binding]; metal-binding site 521010001941 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 521010001942 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 521010001943 hinge; other site 521010001944 active site 521010001945 putative efflux protein, MATE family; Region: matE; TIGR00797 521010001946 MatE; Region: MatE; cl10513 521010001947 MatE; Region: MatE; cl10513 521010001948 elongation factor Tu; Reviewed; Region: PRK00049 521010001949 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 521010001950 G1 box; other site 521010001951 GEF interaction site [polypeptide binding]; other site 521010001952 GTP/Mg2+ binding site [chemical binding]; other site 521010001953 Switch I region; other site 521010001954 G2 box; other site 521010001955 G3 box; other site 521010001956 Switch II region; other site 521010001957 G4 box; other site 521010001958 G5 box; other site 521010001959 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 521010001960 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 521010001961 Antibiotic Binding Site [chemical binding]; other site 521010001962 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 521010001963 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 521010001964 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 521010001965 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 521010001966 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 521010001967 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 521010001968 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 521010001969 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 521010001970 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 521010001971 putative translocon binding site; other site 521010001972 protein-rRNA interface [nucleotide binding]; other site 521010001973 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 521010001974 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 521010001975 G-X-X-G motif; other site 521010001976 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 521010001977 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 521010001978 23S rRNA interface [nucleotide binding]; other site 521010001979 5S rRNA interface [nucleotide binding]; other site 521010001980 putative antibiotic binding site [chemical binding]; other site 521010001981 L25 interface [polypeptide binding]; other site 521010001982 L27 interface [polypeptide binding]; other site 521010001983 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 521010001984 23S rRNA interface [nucleotide binding]; other site 521010001985 putative translocon interaction site; other site 521010001986 signal recognition particle (SRP54) interaction site; other site 521010001987 L23 interface [polypeptide binding]; other site 521010001988 trigger factor interaction site; other site 521010001989 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 521010001990 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 521010001991 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 521010001992 KOW motif; Region: KOW; cl00354 521010001993 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 521010001994 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 521010001995 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 521010001996 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 521010001997 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 521010001998 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 521010001999 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521010002000 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521010002001 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 521010002002 5S rRNA interface [nucleotide binding]; other site 521010002003 23S rRNA interface [nucleotide binding]; other site 521010002004 L5 interface [polypeptide binding]; other site 521010002005 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 521010002006 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 521010002007 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 521010002008 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30_like; cl00203 521010002009 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 521010002010 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 521010002011 SecY translocase; Region: SecY; pfam00344 521010002012 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 521010002013 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 521010002014 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 521010002015 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 521010002016 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 521010002017 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 521010002018 alphaNTD - beta interaction site [polypeptide binding]; other site 521010002019 alphaNTD homodimer interface [polypeptide binding]; other site 521010002020 alphaNTD - beta' interaction site [polypeptide binding]; other site 521010002021 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 521010002022 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 521010002023 phosphodiesterase; Provisional; Region: PRK12704 521010002024 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 521010002025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521010002026 Zn2+ binding site [ion binding]; other site 521010002027 Mg2+ binding site [ion binding]; other site 521010002028 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 521010002029 putative active site [active] 521010002030 metal binding site [ion binding]; metal-binding site 521010002031 homodimer binding site [polypeptide binding]; other site 521010002032 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 521010002033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010002034 Spore germination protein [General function prediction only]; Region: COG5401 521010002035 Sporulation and spore germination; Region: Germane; cl11253 521010002036 GTP-binding protein Der; Reviewed; Region: PRK00093 521010002037 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 521010002038 G1 box; other site 521010002039 GTP/Mg2+ binding site [chemical binding]; other site 521010002040 Switch I region; other site 521010002041 G2 box; other site 521010002042 Switch II region; other site 521010002043 G3 box; other site 521010002044 G4 box; other site 521010002045 G5 box; other site 521010002046 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 521010002047 G1 box; other site 521010002048 GTP/Mg2+ binding site [chemical binding]; other site 521010002049 Switch I region; other site 521010002050 G2 box; other site 521010002051 G3 box; other site 521010002052 Switch II region; other site 521010002053 G4 box; other site 521010002054 G5 box; other site 521010002055 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 521010002056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521010002057 motif II; other site 521010002058 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521010002059 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010002060 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010002061 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521010002062 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 521010002063 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 521010002064 dimer interface [polypeptide binding]; other site 521010002065 motif 1; other site 521010002066 active site 521010002067 motif 2; other site 521010002068 motif 3; other site 521010002069 phenylalanyl-tRNA synthetase, beta subunit; Region: pheT_arch; TIGR00471 521010002070 B3/4 domain; Region: B3_4; cl11458 521010002071 tRNA synthetase B5 domain; Region: B5; cl08394 521010002072 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 521010002073 dimer interface [polypeptide binding]; other site 521010002074 motif 1; other site 521010002075 motif 3; other site 521010002076 motif 2; other site 521010002077 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 521010002078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521010002079 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 521010002080 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 521010002081 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 521010002082 chaperone protein DnaJ; Provisional; Region: PRK14285 521010002083 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521010002084 HSP70 interaction site [polypeptide binding]; other site 521010002085 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521010002086 dimer interface [polypeptide binding]; other site 521010002087 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 521010002088 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 521010002089 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 521010002090 dimer interface [polypeptide binding]; other site 521010002091 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 521010002092 NAD synthetase; Provisional; Region: PRK13981 521010002093 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 521010002094 active site 521010002095 catalytic triad [active] 521010002096 dimer interface [polypeptide binding]; other site 521010002097 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 521010002098 homodimer interface [polypeptide binding]; other site 521010002099 NAD binding pocket [chemical binding]; other site 521010002100 ATP binding pocket [chemical binding]; other site 521010002101 Mg binding site [ion binding]; other site 521010002102 active-site loop [active] 521010002103 Type III pantothenate kinase; Region: Pan_kinase; cl09130 521010002104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521010002105 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521010002106 active site 521010002107 catalytic tetrad [active] 521010002108 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 521010002109 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 521010002110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521010002111 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 521010002112 active site 521010002113 putative catalytic site [active] 521010002114 phosphate binding site A [ion binding]; other site 521010002115 DNA binding site [nucleotide binding] 521010002116 metal binding site A [ion binding]; metal-binding site 521010002117 putative AP binding site [nucleotide binding]; other site 521010002118 putative metal binding site B [ion binding]; other site 521010002119 phosphate binding site B [ion binding]; other site 521010002120 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521010002121 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521010002122 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521010002123 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521010002124 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521010002125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010002126 binding surface 521010002127 TPR motif; other site 521010002128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010002129 binding surface 521010002130 TPR motif; other site 521010002131 TPR repeat; Region: TPR_11; pfam13414 521010002132 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 521010002133 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 521010002134 translation elongation factor EF-G; Region: EF-G; TIGR00484 521010002135 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521010002136 G1 box; other site 521010002137 putative GEF interaction site [polypeptide binding]; other site 521010002138 GTP/Mg2+ binding site [chemical binding]; other site 521010002139 Switch I region; other site 521010002140 G2 box; other site 521010002141 G3 box; other site 521010002142 Switch II region; other site 521010002143 G4 box; other site 521010002144 G5 box; other site 521010002145 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 521010002146 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521010002147 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 521010002148 KTSC domain; Region: KTSC; pfam13619 521010002149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521010002150 binding surface 521010002151 TPR motif; other site 521010002152 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 521010002153 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 521010002154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521010002155 active site 521010002156 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 521010002157 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 521010002158 N- and C-terminal domain interface [polypeptide binding]; other site 521010002159 active site 521010002160 MgATP binding site [chemical binding]; other site 521010002161 catalytic site [active] 521010002162 metal binding site [ion binding]; metal-binding site 521010002163 carbohydrate binding site [chemical binding]; other site 521010002164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 521010002165 Sporulation related domain; Region: SPOR; cl10051 521010002166 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 521010002167 CoA-binding site [chemical binding]; other site 521010002168 ATP-binding [chemical binding]; other site 521010002169 DNA polymerase I; Region: pola; TIGR00593 521010002170 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 521010002171 active site 521010002172 metal binding site 1 [ion binding]; metal-binding site 521010002173 putative 5' ssDNA interaction site; other site 521010002174 metal binding site 3; metal-binding site 521010002175 metal binding site 2 [ion binding]; metal-binding site 521010002176 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 521010002177 putative DNA binding site [nucleotide binding]; other site 521010002178 putative metal binding site [ion binding]; other site 521010002179 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 521010002180 active site 521010002181 catalytic site [active] 521010002182 substrate binding site [chemical binding]; other site 521010002183 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 521010002184 active site 521010002185 DNA binding site [nucleotide binding] 521010002186 catalytic site [active] 521010002187 Flagellar protein FliS; Region: FliS; cl00654 521010002188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010002189 Response regulator receiver domain; Region: Response_reg; pfam00072 521010002190 active site 521010002191 phosphorylation site [posttranslational modification] 521010002192 intermolecular recognition site; other site 521010002193 dimerization interface [polypeptide binding]; other site 521010002194 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350 521010002195 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 521010002196 nucleotide binding pocket [chemical binding]; other site 521010002197 K-X-D-G motif; other site 521010002198 catalytic site [active] 521010002199 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 521010002200 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 521010002201 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 521010002202 Dimer interface [polypeptide binding]; other site 521010002203 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 521010002204 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 521010002205 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 521010002206 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 521010002207 dimerization domain swap beta strand [polypeptide binding]; other site 521010002208 regulatory protein interface [polypeptide binding]; other site 521010002209 active site 521010002210 regulatory phosphorylation site [posttranslational modification]; other site 521010002211 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 521010002212 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 521010002213 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 521010002214 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 521010002215 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 521010002216 HPr interaction site; other site 521010002217 glycerol kinase (GK) interaction site [polypeptide binding]; other site 521010002218 active site 521010002219 phosphorylation site [posttranslational modification] 521010002220 heat shock protein 90; Provisional; Region: PRK05218 521010002221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 521010002222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521010002223 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 521010002224 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 521010002225 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010002226 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010002227 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010002228 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 521010002229 putative CheA interaction surface; other site 521010002230 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 521010002231 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 521010002232 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521010002233 putative binding surface; other site 521010002234 active site 521010002235 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 521010002236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010002237 ATP binding site [chemical binding]; other site 521010002238 Mg2+ binding site [ion binding]; other site 521010002239 G-X-G motif; other site 521010002240 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 521010002241 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 521010002242 CheB methylesterase; Region: CheB_methylest; pfam01339 521010002243 chromosome segregation protein; Provisional; Region: PRK01156 521010002244 Response regulator receiver domain; Region: Response_reg; pfam00072 521010002245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010002246 active site 521010002247 phosphorylation site [posttranslational modification] 521010002248 intermolecular recognition site; other site 521010002249 dimerization interface [polypeptide binding]; other site 521010002250 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 521010002251 nucleotide binding site [chemical binding]; other site 521010002252 homodimeric interface [polypeptide binding]; other site 521010002253 uridine monophosphate binding site [chemical binding]; other site 521010002254 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521010002255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521010002256 active site 521010002257 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 521010002258 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 521010002259 Walker A/P-loop; other site 521010002260 ATP binding site [chemical binding]; other site 521010002261 Q-loop/lid; other site 521010002262 ABC transporter signature motif; other site 521010002263 Walker B; other site 521010002264 D-loop; other site 521010002265 H-loop/switch region; other site 521010002266 CTP synthase; Region: PyrG; TIGR00337 521010002267 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 521010002268 Catalytic site [active] 521010002269 active site 521010002270 UTP binding site [chemical binding]; other site 521010002271 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 521010002272 active site 521010002273 putative oxyanion hole; other site 521010002274 catalytic triad [active] 521010002275 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 521010002276 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002277 putative CheW interface [polypeptide binding]; other site 521010002278 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 521010002279 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 521010002280 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 521010002281 generic binding surface I; other site 521010002282 generic binding surface II; other site 521010002283 YGGT family; Region: YGGT; cl00508 521010002284 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 521010002285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010002286 ATP binding site [chemical binding]; other site 521010002287 putative Mg++ binding site [ion binding]; other site 521010002288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010002289 nucleotide binding region [chemical binding]; other site 521010002290 ATP-binding site [chemical binding]; other site 521010002291 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 521010002292 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 521010002293 putative efflux protein, MATE family; Region: matE; TIGR00797 521010002294 MatE; Region: MatE; cl10513 521010002295 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 521010002296 MatE; Region: MatE; cl10513 521010002297 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 521010002298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521010002299 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 521010002300 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 521010002301 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 521010002302 active site 521010002303 HIGH motif; other site 521010002304 KMSKS motif; other site 521010002305 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 521010002306 tRNA binding surface [nucleotide binding]; other site 521010002307 anticodon binding site; other site 521010002308 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 521010002309 putative tRNA-binding site [nucleotide binding]; other site 521010002310 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521010002311 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 521010002312 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 521010002313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010002314 Competence protein; Region: Competence; cl00471 521010002315 CAAX protease self-immunity; Region: Abi; cl00558 521010002316 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 521010002317 AMP-binding enzyme; Region: AMP-binding; cl15778 521010002318 AMP-binding enzyme; Region: AMP-binding; cl15778 521010002319 arginyl-tRNA synthetase; Region: argS; TIGR00456 521010002320 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 521010002321 active site 521010002322 HIGH motif; other site 521010002323 KMSK motif region; other site 521010002324 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521010002325 tRNA binding surface [nucleotide binding]; other site 521010002326 anticodon binding site; other site 521010002327 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521010002328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002329 dimer interface [polypeptide binding]; other site 521010002330 putative CheW interface [polypeptide binding]; other site 521010002331 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521010002332 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002333 putative CheW interface [polypeptide binding]; other site 521010002334 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14650 521010002335 FAD binding domain; Region: FAD_binding_4; pfam01565 521010002336 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521010002337 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521010002338 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521010002339 KMSKS motif; other site 521010002340 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521010002341 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 521010002342 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 521010002343 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 521010002344 dimer interface [polypeptide binding]; other site 521010002345 active site 521010002346 glycine-pyridoxal phosphate binding site [chemical binding]; other site 521010002347 folate binding site [chemical binding]; other site 521010002348 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521010002349 HSP70 interaction site [polypeptide binding]; other site 521010002350 Borrelia burgdorferi attachment protein P66; Region: Attachment_P66; pfam11263 521010002351 L-lactate permease; Region: Lactate_perm; cl00701 521010002352 glycolate transporter; Provisional; Region: PRK09695 521010002353 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 521010002354 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 521010002355 CheD chemotactic sensory transduction; Region: CheD; cl00810 521010002356 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 521010002357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002358 Family description; Region: UvrD_C_2; cl15862 521010002359 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 521010002360 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 521010002361 metal binding site [ion binding]; metal-binding site 521010002362 dimer interface [polypeptide binding]; other site 521010002363 trigger factor; Provisional; Region: tig; PRK01490 521010002364 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 521010002365 Clp protease; Region: CLP_protease; pfam00574 521010002366 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521010002367 oligomer interface [polypeptide binding]; other site 521010002368 active site residues [active] 521010002369 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 521010002370 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 521010002371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010002372 Walker A motif; other site 521010002373 ATP binding site [chemical binding]; other site 521010002374 Walker B motif; other site 521010002375 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 521010002376 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 521010002377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010002378 Walker A motif; other site 521010002379 ATP binding site [chemical binding]; other site 521010002380 Walker B motif; other site 521010002381 arginine finger; other site 521010002382 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 521010002383 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 521010002384 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 521010002385 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521010002386 RNA binding surface [nucleotide binding]; other site 521010002387 Cation efflux family; Region: Cation_efflux; cl00316 521010002388 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 521010002389 active site 521010002390 catalytic motif [active] 521010002391 Zn binding site [ion binding]; other site 521010002392 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 521010002393 DHH family; Region: DHH; pfam01368 521010002394 DHHA1 domain; Region: DHHA1; pfam02272 521010002395 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 521010002396 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 521010002397 DJ-1 family protein; Region: not_thiJ; TIGR01383 521010002398 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 521010002399 conserved cys residue [active] 521010002400 Acetokinase family; Region: Acetate_kinase; cl01029 521010002401 acetate kinase; Region: ackA; TIGR00016 521010002402 transcription-repair coupling factor; Provisional; Region: PRK10689 521010002403 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 521010002404 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 521010002405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010002406 ATP binding site [chemical binding]; other site 521010002407 putative Mg++ binding site [ion binding]; other site 521010002408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010002409 nucleotide binding region [chemical binding]; other site 521010002410 ATP-binding site [chemical binding]; other site 521010002411 TRCF domain; Region: TRCF; cl04088 521010002412 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002413 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 521010002414 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002415 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002416 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 521010002417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002418 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 521010002419 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 521010002420 active site 521010002421 metal binding site [ion binding]; metal-binding site 521010002422 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 521010002423 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 521010002424 putative active site [active] 521010002425 putative metal binding site [ion binding]; other site 521010002426 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 521010002427 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521010002428 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 521010002429 metal binding site [ion binding]; metal-binding site 521010002430 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 521010002431 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521010002432 active site 521010002433 phosphorylation site [posttranslational modification] 521010002434 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 521010002435 active site 521010002436 P-loop; other site 521010002437 phosphorylation site [posttranslational modification] 521010002438 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521010002439 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521010002440 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521010002441 putative substrate binding site [chemical binding]; other site 521010002442 putative ATP binding site [chemical binding]; other site 521010002443 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 521010002444 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002445 Family description; Region: UvrD_C_2; cl15862 521010002446 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 521010002447 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 521010002448 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 521010002449 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 521010002450 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 521010002451 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 521010002452 active site 521010002453 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 521010002454 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 521010002455 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 521010002456 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 521010002457 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 521010002458 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 521010002459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 521010002460 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 521010002461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 521010002462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010002463 dimer interface [polypeptide binding]; other site 521010002464 conserved gate region; other site 521010002465 putative PBP binding loops; other site 521010002466 ABC-ATPase subunit interface; other site 521010002467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010002468 dimer interface [polypeptide binding]; other site 521010002469 conserved gate region; other site 521010002470 putative PBP binding loops; other site 521010002471 ABC-ATPase subunit interface; other site 521010002472 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 521010002473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002474 Walker A/P-loop; other site 521010002475 ATP binding site [chemical binding]; other site 521010002476 Q-loop/lid; other site 521010002477 ABC transporter signature motif; other site 521010002478 Walker B; other site 521010002479 D-loop; other site 521010002480 H-loop/switch region; other site 521010002481 TOBE domain; Region: TOBE_2; cl01440 521010002482 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 521010002483 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 521010002484 GTP/Mg2+ binding site [chemical binding]; other site 521010002485 G4 box; other site 521010002486 G5 box; other site 521010002487 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002488 G1 box; other site 521010002489 Switch I region; other site 521010002490 G2 box; other site 521010002491 G3 box; other site 521010002492 Switch II region; other site 521010002493 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 521010002494 putative active site cavity [active] 521010002495 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 521010002496 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521010002497 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521010002498 active site turn [active] 521010002499 phosphorylation site [posttranslational modification] 521010002500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521010002501 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521010002502 metal binding site 2 [ion binding]; metal-binding site 521010002503 putative DNA binding helix; other site 521010002504 metal binding site 1 [ion binding]; metal-binding site 521010002505 structural Zn2+ binding site [ion binding]; other site 521010002506 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521010002507 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521010002508 ring oligomerisation interface [polypeptide binding]; other site 521010002509 ATP/Mg binding site [chemical binding]; other site 521010002510 stacking interactions; other site 521010002511 hinge regions; other site 521010002512 Preprotein translocase subunit; Region: YajC; cl00806 521010002513 protein-export membrane protein SecD; Region: secD; TIGR01129 521010002514 Protein export membrane protein; Region: SecD_SecF; cl14618 521010002515 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 521010002516 Protein export membrane protein; Region: SecD_SecF; cl14618 521010002517 chaperone protein DnaJ; Provisional; Region: PRK14299 521010002518 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521010002519 HSP70 interaction site [polypeptide binding]; other site 521010002520 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521010002521 dimer interface [polypeptide binding]; other site 521010002522 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 521010002523 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 521010002524 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521010002525 active site 521010002526 dimer interface [polypeptide binding]; other site 521010002527 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521010002528 catalytic core [active] 521010002529 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521010002530 lysyl-tRNA synthetase, archaeal and spirochete; Region: lysS_arch; TIGR00467 521010002531 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 521010002532 active site 521010002533 HIGH motif; other site 521010002534 KMSKS motif; other site 521010002535 GTPase Era; Reviewed; Region: era; PRK00089 521010002536 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 521010002537 G1 box; other site 521010002538 GTP/Mg2+ binding site [chemical binding]; other site 521010002539 Switch I region; other site 521010002540 G2 box; other site 521010002541 Switch II region; other site 521010002542 G3 box; other site 521010002543 G4 box; other site 521010002544 G5 box; other site 521010002545 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 521010002546 Double zinc ribbon; Region: DZR; pfam12773 521010002547 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 521010002548 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 521010002549 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521010002550 active site 521010002551 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 521010002552 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 521010002553 active site 521010002554 metal binding site [ion binding]; metal-binding site 521010002555 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 521010002556 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 521010002557 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521010002558 putative binding surface; other site 521010002559 active site 521010002560 P2 response regulator binding domain; Region: P2; pfam07194 521010002561 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 521010002562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010002563 ATP binding site [chemical binding]; other site 521010002564 Mg2+ binding site [ion binding]; other site 521010002565 G-X-G motif; other site 521010002566 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 521010002567 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 521010002568 putative CheA interaction surface; other site 521010002569 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 521010002570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010002571 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 521010002572 Chemotaxis phosphatase CheX; Region: CheX; cl15816 521010002573 Response regulator receiver domain; Region: Response_reg; pfam00072 521010002574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010002575 active site 521010002576 phosphorylation site [posttranslational modification] 521010002577 intermolecular recognition site; other site 521010002578 dimerization interface [polypeptide binding]; other site 521010002579 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 521010002580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521010002581 motif II; other site 521010002582 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 521010002583 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 521010002584 Walker A/P-loop; other site 521010002585 ATP binding site [chemical binding]; other site 521010002586 Q-loop/lid; other site 521010002587 ABC transporter signature motif; other site 521010002588 Walker B; other site 521010002589 D-loop; other site 521010002590 H-loop/switch region; other site 521010002591 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002592 Walker A/P-loop; other site 521010002593 ATP binding site [chemical binding]; other site 521010002594 Q-loop/lid; other site 521010002595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002596 ABC transporter signature motif; other site 521010002597 Walker B; other site 521010002598 D-loop; other site 521010002599 H-loop/switch region; other site 521010002600 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521010002601 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521010002602 TM-ABC transporter signature motif; other site 521010002603 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521010002604 TM-ABC transporter signature motif; other site 521010002605 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002606 dimer interface [polypeptide binding]; other site 521010002607 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 521010002608 putative CheW interface [polypeptide binding]; other site 521010002609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 521010002610 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521010002611 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002612 dimer interface [polypeptide binding]; other site 521010002613 putative CheW interface [polypeptide binding]; other site 521010002614 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 521010002615 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 521010002616 Ligand Binding Site [chemical binding]; other site 521010002617 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 521010002618 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 521010002619 dimer interface [polypeptide binding]; other site 521010002620 active site 521010002621 isopentenyl-diphosphate delta-isomerase, type 2; Region: IPP_isom_2; TIGR02151 521010002622 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 521010002623 homotetramer interface [polypeptide binding]; other site 521010002624 FMN binding site [chemical binding]; other site 521010002625 homodimer contacts [polypeptide binding]; other site 521010002626 putative active site [active] 521010002627 putative substrate binding site [chemical binding]; other site 521010002628 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 521010002629 homodimer interface [polypeptide binding]; other site 521010002630 catalytic residues [active] 521010002631 NAD binding site [chemical binding]; other site 521010002632 substrate binding pocket [chemical binding]; other site 521010002633 flexible flap; other site 521010002634 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 521010002635 Phosphomevalonate kinase [Lipid metabolism]; Region: ERG8; COG3890 521010002636 mevalonate kinase; Region: mevalon_kin; TIGR00549 521010002637 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 521010002638 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 521010002639 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 521010002640 dimerization interface [polypeptide binding]; other site 521010002641 DPS ferroxidase diiron center [ion binding]; other site 521010002642 ion pore; other site 521010002643 elongation factor G; Reviewed; Region: PRK13351 521010002644 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521010002645 G1 box; other site 521010002646 putative GEF interaction site [polypeptide binding]; other site 521010002647 GTP/Mg2+ binding site [chemical binding]; other site 521010002648 Switch I region; other site 521010002649 G2 box; other site 521010002650 G3 box; other site 521010002651 Switch II region; other site 521010002652 G4 box; other site 521010002653 G5 box; other site 521010002654 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521010002655 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 521010002656 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521010002657 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 521010002658 signal recognition particle protein; Provisional; Region: PRK10867 521010002659 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 521010002660 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521010002661 P loop; other site 521010002662 GTP binding site [chemical binding]; other site 521010002663 Signal peptide binding domain; Region: SRP_SPB; pfam02978 521010002664 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 521010002665 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 521010002666 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 521010002667 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14594 521010002668 RimM N-terminal domain; Region: RimM; pfam01782 521010002669 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 521010002670 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 521010002671 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 521010002672 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521010002673 active site 521010002674 nucleotide binding site [chemical binding]; other site 521010002675 HIGH motif; other site 521010002676 KMSKS motif; other site 521010002677 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 521010002678 Phosphopantetheine attachment site; Region: PP-binding; cl09936 521010002679 ribonuclease III; Reviewed; Region: rnc; PRK00102 521010002680 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 521010002681 dimerization interface [polypeptide binding]; other site 521010002682 active site 521010002683 metal binding site [ion binding]; metal-binding site 521010002684 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 521010002685 dsRNA binding site [nucleotide binding]; other site 521010002686 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 521010002687 active site 521010002688 NTP binding site [chemical binding]; other site 521010002689 metal binding triad [ion binding]; metal-binding site 521010002690 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 521010002691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521010002692 YceG-like family; Region: YceG; pfam02618 521010002693 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 521010002694 dimerization interface [polypeptide binding]; other site 521010002695 DNA primase, catalytic core; Region: dnaG; TIGR01391 521010002696 CHC2 zinc finger; Region: zf-CHC2; cl15369 521010002697 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 521010002698 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 521010002699 active site 521010002700 metal binding site [ion binding]; metal-binding site 521010002701 interdomain interaction site; other site 521010002702 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 521010002703 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 521010002704 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 521010002705 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521010002706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521010002707 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521010002708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521010002709 DNA binding residues [nucleotide binding] 521010002710 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 521010002711 Putative zinc ribbon domain; Region: DUF164; pfam02591 521010002712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010002713 binding surface 521010002714 TPR repeat; Region: TPR_11; pfam13414 521010002715 TPR motif; other site 521010002716 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 521010002717 Cell division protein FtsA; Region: FtsA; cl11496 521010002718 rod shape-determining protein MreC; Region: mreC; TIGR00219 521010002719 rod shape-determining protein MreC; Region: MreC; pfam04085 521010002720 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 521010002721 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521010002722 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521010002723 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521010002724 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521010002725 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 521010002726 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 521010002727 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 521010002728 active site 521010002729 dimer interface [polypeptide binding]; other site 521010002730 motif 1; other site 521010002731 motif 2; other site 521010002732 motif 3; other site 521010002733 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 521010002734 anticodon binding site; other site 521010002735 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 521010002736 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 521010002737 putative active site; other site 521010002738 putative metal binding residues [ion binding]; other site 521010002739 signature motif; other site 521010002740 putative triphosphate binding site [ion binding]; other site 521010002741 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 521010002742 Cation transport protein; Region: TrkH; cl10514 521010002743 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 521010002744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521010002745 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 521010002746 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521010002747 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521010002748 P-loop; other site 521010002749 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 521010002750 active site 521010002751 ADP/pyrophosphate binding site [chemical binding]; other site 521010002752 dimerization interface [polypeptide binding]; other site 521010002753 allosteric effector site; other site 521010002754 fructose-1,6-bisphosphate binding site; other site 521010002755 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 521010002756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521010002757 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521010002758 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 521010002759 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 521010002760 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 521010002761 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 521010002762 active site 521010002763 dimer interface [polypeptide binding]; other site 521010002764 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 521010002765 dimer interface [polypeptide binding]; other site 521010002766 active site 521010002767 ParB-like nuclease domain; Region: ParBc; cl02129 521010002768 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 521010002769 Transglycosylase; Region: Transgly; cl07896 521010002770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521010002771 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 521010002772 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 521010002773 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 521010002774 rare lipoprotein A; Region: rlpA; TIGR00413 521010002775 Sporulation related domain; Region: SPOR; cl10051 521010002776 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 521010002777 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521010002778 FMN binding site [chemical binding]; other site 521010002779 active site 521010002780 catalytic residues [active] 521010002781 substrate binding site [chemical binding]; other site 521010002782 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 521010002783 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521010002784 active site 521010002785 HIGH motif; other site 521010002786 nucleotide binding site [chemical binding]; other site 521010002787 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521010002788 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 521010002789 active site 521010002790 KMSKS motif; other site 521010002791 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 521010002792 tRNA binding surface [nucleotide binding]; other site 521010002793 anticodon binding site; other site 521010002794 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 521010002795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 521010002796 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521010002797 oligomerisation interface [polypeptide binding]; other site 521010002798 mobile loop; other site 521010002799 roof hairpin; other site 521010002800 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 521010002801 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002802 Walker A/P-loop; other site 521010002803 ATP binding site [chemical binding]; other site 521010002804 Q-loop/lid; other site 521010002805 ABC transporter signature motif; other site 521010002806 Walker B; other site 521010002807 D-loop; other site 521010002808 H-loop/switch region; other site 521010002809 ABC transporter; Region: ABC_tran_2; pfam12848 521010002810 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521010002811 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521010002812 active site 521010002813 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 521010002814 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 521010002815 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 521010002816 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521010002817 minor groove reading motif; other site 521010002818 helix-hairpin-helix signature motif; other site 521010002819 substrate binding pocket [chemical binding]; other site 521010002820 active site 521010002821 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 521010002822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010002823 dimer interface [polypeptide binding]; other site 521010002824 conserved gate region; other site 521010002825 putative PBP binding loops; other site 521010002826 ABC-ATPase subunit interface; other site 521010002827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 521010002828 Septum formation initiator; Region: DivIC; cl11433 521010002829 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 521010002830 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 521010002831 ABC-2 type transporter; Region: ABC2_membrane; cl11417 521010002832 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521010002833 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002834 Walker A/P-loop; other site 521010002835 ATP binding site [chemical binding]; other site 521010002836 Q-loop/lid; other site 521010002837 ABC transporter signature motif; other site 521010002838 Walker B; other site 521010002839 D-loop; other site 521010002840 H-loop/switch region; other site 521010002841 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521010002842 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 521010002843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521010002844 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 521010002845 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521010002846 oligomer interface [polypeptide binding]; other site 521010002847 active site residues [active] 521010002848 Domain of unknown function (DUF368); Region: DUF368; cl00893 521010002849 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 521010002850 putative metal binding site [ion binding]; other site 521010002851 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 521010002852 Peptidase family M23; Region: Peptidase_M23; pfam01551 521010002853 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521010002854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010002855 active site 521010002856 phosphorylation site [posttranslational modification] 521010002857 intermolecular recognition site; other site 521010002858 dimerization interface [polypeptide binding]; other site 521010002859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010002860 Walker A motif; other site 521010002861 ATP binding site [chemical binding]; other site 521010002862 Walker B motif; other site 521010002863 arginine finger; other site 521010002864 Helix-turn-helix domains; Region: HTH; cl00088 521010002865 sensory histidine kinase AtoS; Provisional; Region: PRK11360 521010002866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 521010002867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010002868 ATP binding site [chemical binding]; other site 521010002869 G-X-G motif; other site 521010002870 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812 521010002871 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010002872 Colicin V production protein; Region: Colicin_V; cl00567 521010002873 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 521010002874 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 521010002875 homodimer interface [polypeptide binding]; other site 521010002876 active site 521010002877 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 521010002878 dimer interface [polypeptide binding]; other site 521010002879 pyridoxal binding site [chemical binding]; other site 521010002880 ATP binding site [chemical binding]; other site 521010002881 UGMP family protein; Validated; Region: PRK09604 521010002882 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 521010002883 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 521010002884 NodB motif; other site 521010002885 putative active site [active] 521010002886 putative catalytic site [active] 521010002887 Zn binding site [ion binding]; other site 521010002888 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 521010002889 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521010002890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521010002891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521010002892 DNA binding residues [nucleotide binding] 521010002893 Rod binding protein; Region: Rod-binding; cl01626 521010002894 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 521010002895 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 521010002896 SAF-like; Region: SAF_2; pfam13144 521010002897 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 521010002898 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 521010002899 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 521010002900 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 521010002901 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 521010002902 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 521010002903 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 521010002904 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521010002905 active site 521010002906 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 521010002907 Protein of unknown function (DUF464); Region: DUF464; cl01080 521010002908 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 521010002909 GTPase CgtA; Reviewed; Region: obgE; PRK12299 521010002910 GTP1/OBG; Region: GTP1_OBG; pfam01018 521010002911 Obg GTPase; Region: Obg; cd01898 521010002912 G1 box; other site 521010002913 GTP/Mg2+ binding site [chemical binding]; other site 521010002914 Switch I region; other site 521010002915 G2 box; other site 521010002916 G3 box; other site 521010002917 Switch II region; other site 521010002918 G4 box; other site 521010002919 G5 box; other site 521010002920 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 521010002921 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 521010002922 active site 521010002923 (T/H)XGH motif; other site 521010002924 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 521010002925 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 521010002926 Oligomerisation domain; Region: Oligomerisation; cl00519 521010002927 SpoVG; Region: SpoVG; cl00915 521010002928 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 521010002929 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 521010002930 5S rRNA interface [nucleotide binding]; other site 521010002931 CTC domain interface [polypeptide binding]; other site 521010002932 L16 interface [polypeptide binding]; other site 521010002933 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 521010002934 putative active site [active] 521010002935 catalytic residue [active] 521010002936 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 521010002937 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 521010002938 Ligand Binding Site [chemical binding]; other site 521010002939 FtsH Extracellular; Region: FtsH_ext; pfam06480 521010002940 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521010002941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010002942 Walker A motif; other site 521010002943 ATP binding site [chemical binding]; other site 521010002944 Walker B motif; other site 521010002945 arginine finger; other site 521010002946 Peptidase family M41; Region: Peptidase_M41; pfam01434 521010002947 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 521010002948 thymidylate kinase; Region: DTMP_kinase; TIGR00041 521010002949 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 521010002950 TMP-binding site; other site 521010002951 ATP-binding site [chemical binding]; other site 521010002952 Family of unknown function (DUF490); Region: DUF490; pfam04357 521010002953 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 521010002954 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 521010002955 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 521010002956 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 521010002957 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 521010002958 Surface antigen; Region: Bac_surface_Ag; cl03097 521010002959 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 521010002960 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 521010002961 MutS domain I; Region: MutS_I; pfam01624 521010002962 MutS domain II; Region: MutS_II; pfam05188 521010002963 MutS family domain IV; Region: MutS_IV; pfam05190 521010002964 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 521010002965 Walker A/P-loop; other site 521010002966 ATP binding site [chemical binding]; other site 521010002967 Q-loop/lid; other site 521010002968 ABC transporter signature motif; other site 521010002969 Walker B; other site 521010002970 D-loop; other site 521010002971 H-loop/switch region; other site 521010002972 comF family protein; Region: comF; TIGR00201 521010002973 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521010002974 active site 521010002975 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 521010002976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 521010002977 transcription termination factor NusA; Region: NusA; TIGR01953 521010002978 NusA N-terminal domain; Region: NusA_N; pfam08529 521010002979 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 521010002980 RNA binding site [nucleotide binding]; other site 521010002981 homodimer interface [polypeptide binding]; other site 521010002982 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 521010002983 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 521010002984 G-X-X-G motif; other site 521010002985 transcription termination factor Rho; Provisional; Region: PRK12678 521010002986 translation initiation factor IF-2; Region: IF-2; TIGR00487 521010002987 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521010002988 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 521010002989 G1 box; other site 521010002990 putative GEF interaction site [polypeptide binding]; other site 521010002991 GTP/Mg2+ binding site [chemical binding]; other site 521010002992 Switch I region; other site 521010002993 G2 box; other site 521010002994 G3 box; other site 521010002995 Switch II region; other site 521010002996 G4 box; other site 521010002997 G5 box; other site 521010002998 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 521010002999 Translation-initiation factor 2; Region: IF-2; pfam11987 521010003000 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 521010003001 Ribosome-binding factor A; Region: RBFA; cl00542 521010003002 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 521010003003 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 521010003004 RNA binding site [nucleotide binding]; other site 521010003005 active site 521010003006 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 521010003007 16S/18S rRNA binding site [nucleotide binding]; other site 521010003008 S13e-L30e interaction site [polypeptide binding]; other site 521010003009 25S rRNA binding site [nucleotide binding]; other site 521010003010 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 521010003011 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 521010003012 RNase E interface [polypeptide binding]; other site 521010003013 trimer interface [polypeptide binding]; other site 521010003014 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 521010003015 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 521010003016 RNase E interface [polypeptide binding]; other site 521010003017 trimer interface [polypeptide binding]; other site 521010003018 active site 521010003019 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 521010003020 putative nucleic acid binding region [nucleotide binding]; other site 521010003021 G-X-X-G motif; other site 521010003022 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521010003023 RNA binding site [nucleotide binding]; other site 521010003024 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 521010003025 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 521010003026 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 521010003027 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 521010003028 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 521010003029 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 521010003030 integral membrane protein MviN; Region: mviN; TIGR01695 521010003031 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 521010003032 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 521010003033 Flavoprotein; Region: Flavoprotein; cl08021 521010003034 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 521010003035 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 521010003036 Na binding site [ion binding]; other site 521010003037 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521010003038 active site 521010003039 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 521010003040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521010003041 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521010003042 TIGR00255 family protein; Region: TIGR00255 521010003043 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 521010003044 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 521010003045 cytidylate kinase; Provisional; Region: PRK04182 521010003046 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521010003047 CMP-binding site; other site 521010003048 The sites determining sugar specificity; other site 521010003049 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 521010003050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010003051 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 521010003052 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 521010003053 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 521010003054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010003055 ATP binding site [chemical binding]; other site 521010003056 putative Mg++ binding site [ion binding]; other site 521010003057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010003058 nucleotide binding region [chemical binding]; other site 521010003059 ATP-binding site [chemical binding]; other site 521010003060 Helicase associated domain (HA2); Region: HA2; cl04503 521010003061 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 521010003062 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 521010003063 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 521010003064 active site 521010003065 interdomain interaction site; other site 521010003066 putative metal-binding site [ion binding]; other site 521010003067 nucleotide binding site [chemical binding]; other site 521010003068 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 521010003069 domain I; other site 521010003070 phosphate binding site [ion binding]; other site 521010003071 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 521010003072 domain III; other site 521010003073 nucleotide binding site [chemical binding]; other site 521010003074 DNA binding groove [nucleotide binding] 521010003075 catalytic site [active] 521010003076 domain II; other site 521010003077 domain IV; other site 521010003078 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 521010003079 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 521010003080 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 521010003081 active site 521010003082 metal binding site [ion binding]; metal-binding site 521010003083 DNA binding site [nucleotide binding] 521010003084 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 521010003085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010003086 Walker A/P-loop; other site 521010003087 ATP binding site [chemical binding]; other site 521010003088 Q-loop/lid; other site 521010003089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010003090 ABC transporter signature motif; other site 521010003091 Walker B; other site 521010003092 D-loop; other site 521010003093 H-loop/switch region; other site 521010003094 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521010003095 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 521010003096 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 521010003097 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 521010003098 HIGH motif; other site 521010003099 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 521010003100 active site 521010003101 KMSKS motif; other site 521010003102 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 521010003103 tRNA binding surface [nucleotide binding]; other site 521010003104 anticodon binding site; other site 521010003105 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521010003106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010003107 Walker A motif; other site 521010003108 ATP binding site [chemical binding]; other site 521010003109 Walker B motif; other site 521010003110 arginine finger; other site 521010003111 recombination factor protein RarA; Reviewed; Region: PRK13342 521010003112 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521010003113 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 521010003114 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 521010003115 active site 521010003116 substrate binding site [chemical binding]; other site 521010003117 metal binding site [ion binding]; metal-binding site 521010003118 excinuclease ABC subunit B; Provisional; Region: PRK05298 521010003119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010003120 ATP binding site [chemical binding]; other site 521010003121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010003122 nucleotide binding region [chemical binding]; other site 521010003123 ATP-binding site [chemical binding]; other site 521010003124 Ultra-violet resistance protein B; Region: UvrB; pfam12344 521010003125 UvrB/uvrC motif; Region: UVR; pfam02151 521010003126 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521010003127 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 521010003128 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 521010003129 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 521010003130 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 521010003131 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 521010003132 Amidinotransferase; Region: Amidinotransf; cl12043 521010003133 ornithine carbamoyltransferase; Provisional; Region: PRK04284 521010003134 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521010003135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521010003136 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 521010003137 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 521010003138 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010003139 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010003140 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010003141 P-loop; other site 521010003142 Magnesium ion binding site [ion binding]; other site 521010003143 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010003144 Magnesium ion binding site [ion binding]; other site 521010003145 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010003146 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010003147 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 521010003148 catalytic triad [active] 521010003149 conserved cis-peptide bond; other site 521010003150 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714