-- dump date 20120504_135140 -- class Genbank::misc_feature -- table misc_feature_note -- id note 224326000001 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 224326000002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 224326000003 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 224326000004 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000005 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000006 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326000007 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326000008 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326000009 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 224326000010 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326000011 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 224326000012 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326000013 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 224326000014 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 224326000015 Protein of unknown function (DUF693); Region: DUF693; pfam05113 224326000016 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 224326000017 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326000018 DUF276; Region: DUF276; pfam03434 224326000019 Protein of unknown function (DUF735); Region: DUF735; pfam05246 224326000020 Protein of unknown function (DUF685); Region: DUF685; pfam05085 224326000021 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 224326000022 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 224326000023 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326000024 Borrelia burgdorferi REV protein; Region: Borrelia_REV; pfam03978 224326000025 Mlp lipoprotein family; Region: Mlp; pfam03304 224326000026 ERF superfamily; Region: ERF; pfam04404 224326000027 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000028 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000029 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000030 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000031 P-loop; other site 224326000032 Magnesium ion binding site [ion binding]; other site 224326000033 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000034 Magnesium ion binding site [ion binding]; other site 224326000035 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326000036 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 224326000037 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326000038 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 224326000039 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326000040 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 224326000041 active site 224326000042 catalytic residues [active] 224326000043 DNA binding site [nucleotide binding] 224326000044 Int/Topo IB signature motif; other site 224326000045 Borrelia outer surface protein E; Region: OspE; pfam02471 224326000046 Erp protein C-terminus; Region: Erp_C; pfam06780 224326000047 Protein of unknown function (DUF643); Region: DUF643; pfam04867 224326000048 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326000049 Phage terminase large subunit; Region: Terminase_3; cl12054 224326000050 Terminase-like family; Region: Terminase_6; pfam03237 224326000051 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 224326000052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 224326000053 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 224326000054 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000055 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000056 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326000057 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326000058 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326000059 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 224326000060 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326000061 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 224326000062 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326000063 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 224326000064 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 224326000065 Protein of unknown function (DUF693); Region: DUF693; pfam05113 224326000066 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 224326000067 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326000068 DUF276; Region: DUF276; pfam03434 224326000069 Protein of unknown function (DUF735); Region: DUF735; pfam05246 224326000070 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 224326000071 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 224326000072 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326000073 AAA domain; Region: AAA_13; pfam13166 224326000074 Mlp lipoprotein family; Region: Mlp; pfam03304 224326000075 ERF superfamily; Region: ERF; pfam04404 224326000076 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000077 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000078 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000080 P-loop; other site 224326000081 Magnesium ion binding site [ion binding]; other site 224326000082 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000083 Magnesium ion binding site [ion binding]; other site 224326000084 transferase, transferring glycosyl groups; Region: PLN02939 224326000085 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326000086 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 224326000087 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326000088 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 224326000089 active site 224326000090 Int/Topo IB signature motif; other site 224326000091 catalytic residues [active] 224326000092 DNA binding site [nucleotide binding] 224326000093 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 224326000094 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326000095 Terminase-like family; Region: Terminase_6; pfam03237 224326000096 Phage terminase large subunit; Region: Terminase_3; cl12054 224326000097 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 224326000098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 224326000099 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000100 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000101 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000102 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326000103 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326000104 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326000105 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 224326000106 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326000107 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 224326000108 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326000109 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 224326000110 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 224326000111 Protein of unknown function (DUF693); Region: DUF693; pfam05113 224326000112 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 224326000113 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326000114 DUF276; Region: DUF276; pfam03434 224326000115 Protein of unknown function (DUF735); Region: DUF735; pfam05246 224326000116 Protein of unknown function (DUF685); Region: DUF685; pfam05085 224326000117 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 224326000118 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 224326000119 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326000120 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional; Region: PLN03229 224326000121 Mlp lipoprotein family; Region: Mlp; pfam03304 224326000122 ERF superfamily; Region: ERF; pfam04404 224326000123 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000124 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000125 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000126 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000127 P-loop; other site 224326000128 Magnesium ion binding site [ion binding]; other site 224326000129 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000130 Magnesium ion binding site [ion binding]; other site 224326000131 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326000132 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326000133 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 224326000134 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326000135 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 224326000136 active site 224326000137 Int/Topo IB signature motif; other site 224326000138 catalytic residues [active] 224326000139 DNA binding site [nucleotide binding] 224326000140 ERF superfamily; Region: ERF; pfam04404 224326000141 Borrelia outer surface protein E; Region: OspE; pfam02471 224326000142 V-type ATP synthase subunit I; Validated; Region: PRK05771 224326000143 Protein of unknown function (DUF643); Region: DUF643; pfam04867 224326000144 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326000145 Phage terminase large subunit; Region: Terminase_3; cl12054 224326000146 Terminase-like family; Region: Terminase_6; pfam03237 224326000147 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 224326000148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 224326000149 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 224326000150 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000151 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000152 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000153 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326000154 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326000155 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326000156 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 224326000157 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326000158 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 224326000159 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326000160 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 224326000161 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 224326000162 Protein of unknown function (DUF693); Region: DUF693; pfam05113 224326000163 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 224326000164 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326000165 DUF276; Region: DUF276; pfam03434 224326000166 Protein of unknown function (DUF735); Region: DUF735; pfam05246 224326000167 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 224326000168 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 224326000169 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326000170 Borrelia burgdorferi REV protein; Region: Borrelia_REV; pfam03978 224326000171 Mlp lipoprotein family; Region: Mlp; pfam03304 224326000172 ERF superfamily; Region: ERF; pfam04404 224326000173 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000174 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000175 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000176 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000177 P-loop; other site 224326000178 Magnesium ion binding site [ion binding]; other site 224326000179 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000180 Magnesium ion binding site [ion binding]; other site 224326000181 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326000182 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 224326000183 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326000184 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 224326000185 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326000186 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 224326000187 active site 224326000188 catalytic residues [active] 224326000189 DNA binding site [nucleotide binding] 224326000190 Int/Topo IB signature motif; other site 224326000191 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326000192 Terminase-like family; Region: Terminase_6; pfam03237 224326000193 Phage terminase large subunit; Region: Terminase_3; cl12054 224326000194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 224326000195 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 224326000196 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 224326000197 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000198 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000199 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000200 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326000201 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326000202 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326000203 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 224326000204 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326000205 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 224326000206 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326000207 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 224326000208 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 224326000209 Protein of unknown function (DUF693); Region: DUF693; pfam05113 224326000210 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 224326000211 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326000212 DUF276; Region: DUF276; pfam03434 224326000213 Protein of unknown function (DUF735); Region: DUF735; pfam05246 224326000214 Protein of unknown function (DUF685); Region: DUF685; pfam05085 224326000215 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 224326000216 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 224326000217 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326000218 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 224326000219 Mlp lipoprotein family; Region: Mlp; pfam03304 224326000220 ERF superfamily; Region: ERF; pfam04404 224326000221 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000222 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000223 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000224 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 224326000225 P-loop; other site 224326000226 Magnesium ion binding site [ion binding]; other site 224326000227 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000228 Magnesium ion binding site [ion binding]; other site 224326000229 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326000230 AAA domain; Region: AAA_13; pfam13166 224326000231 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326000232 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 224326000233 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326000234 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 224326000235 active site 224326000236 catalytic residues [active] 224326000237 DNA binding site [nucleotide binding] 224326000238 Int/Topo IB signature motif; other site 224326000239 V-type ATP synthase subunit I; Validated; Region: PRK05771 224326000240 Erp protein C-terminus; Region: Erp_C; pfam06780 224326000241 Protein of unknown function (DUF643); Region: DUF643; pfam04867 224326000242 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326000243 Phage terminase large subunit; Region: Terminase_3; cl12054 224326000244 Terminase-like family; Region: Terminase_6; pfam03237 224326000245 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 224326000246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 224326000247 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 224326000248 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000249 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000250 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326000251 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326000252 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326000253 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 224326000254 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326000255 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 224326000256 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326000257 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 224326000258 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 224326000259 Protein of unknown function (DUF693); Region: DUF693; pfam05113 224326000260 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 224326000261 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326000262 DUF276; Region: DUF276; pfam03434 224326000263 Protein of unknown function (DUF735); Region: DUF735; pfam05246 224326000264 Protein of unknown function (DUF685); Region: DUF685; pfam05085 224326000265 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 224326000266 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 224326000267 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326000268 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 224326000269 Mlp lipoprotein family; Region: Mlp; pfam03304 224326000270 ERF superfamily; Region: ERF; pfam04404 224326000271 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000272 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000273 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000274 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000275 P-loop; other site 224326000276 Magnesium ion binding site [ion binding]; other site 224326000277 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000278 Magnesium ion binding site [ion binding]; other site 224326000279 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 224326000280 fibritin; Provisional; Region: wac; PHA02607 224326000281 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326000282 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 224326000283 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326000284 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 224326000285 active site 224326000286 catalytic residues [active] 224326000287 DNA binding site [nucleotide binding] 224326000288 Int/Topo IB signature motif; other site 224326000289 Borrelia outer surface protein E; Region: OspE; pfam02471 224326000290 Erp protein C-terminus; Region: Erp_C; pfam06780 224326000291 Protein of unknown function (DUF643); Region: DUF643; pfam04867 224326000292 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326000293 Phage terminase large subunit; Region: Terminase_3; cl12054 224326000294 Terminase-like family; Region: Terminase_6; pfam03237 224326000295 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 224326000296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 224326000297 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 224326000298 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000299 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000300 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326000301 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326000302 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326000303 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326000304 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326000305 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 224326000306 Protein of unknown function (DUF693); Region: DUF693; pfam05113 224326000307 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326000308 DUF276; Region: DUF276; pfam03434 224326000309 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 224326000310 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 224326000311 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326000312 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional; Region: PLN03229 224326000313 Mlp lipoprotein family; Region: Mlp; pfam03304 224326000314 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000315 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000316 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000317 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000318 P-loop; other site 224326000319 Magnesium ion binding site [ion binding]; other site 224326000320 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000321 Magnesium ion binding site [ion binding]; other site 224326000322 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326000323 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 224326000324 fzo-like conserved region; Region: Fzo_mitofusin; pfam04799 224326000325 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326000326 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 224326000327 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326000328 Borrelia outer surface protein E; Region: OspE; pfam02471 224326000329 Erp protein C-terminus; Region: Erp_C; pfam06780 224326000330 Protein of unknown function (DUF643); Region: DUF643; pfam04867 224326000331 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326000332 Phage terminase large subunit; Region: Terminase_3; cl12054 224326000333 Terminase-like family; Region: Terminase_6; pfam03237 224326000334 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000335 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000336 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000337 P-loop; other site 224326000338 Magnesium ion binding site [ion binding]; other site 224326000339 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000340 Magnesium ion binding site [ion binding]; other site 224326000341 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326000342 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000343 TM2 domain; Region: TM2; cl00984 224326000344 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 224326000345 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 224326000346 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326000347 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 224326000348 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326000349 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000350 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000351 P-loop; other site 224326000352 Magnesium ion binding site [ion binding]; other site 224326000353 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000354 Magnesium ion binding site [ion binding]; other site 224326000355 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000356 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000357 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326000358 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326000359 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326000360 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 224326000361 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326000362 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 224326000363 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326000364 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 224326000365 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 224326000366 Protein of unknown function (DUF693); Region: DUF693; pfam05113 224326000367 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 224326000368 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326000369 DUF276; Region: DUF276; pfam03434 224326000370 Protein of unknown function (DUF735); Region: DUF735; pfam05246 224326000371 Protein of unknown function (DUF685); Region: DUF685; pfam05085 224326000372 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 224326000373 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 224326000374 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326000375 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 224326000376 Mlp lipoprotein family; Region: Mlp; pfam03304 224326000377 ERF superfamily; Region: ERF; pfam04404 224326000378 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000379 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326000380 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326000381 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000382 P-loop; other site 224326000383 Magnesium ion binding site [ion binding]; other site 224326000384 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326000385 Magnesium ion binding site [ion binding]; other site 224326000386 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326000387 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 224326000388 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326000389 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 224326000390 active site 224326000391 Int/Topo IB signature motif; other site 224326000392 catalytic residues [active] 224326000393 DNA binding site [nucleotide binding] 224326000394 Erp protein C-terminus; Region: Erp_C; pfam06780 224326000395 Protein of unknown function (DUF643); Region: DUF643; pfam04867 224326000396 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326000397 Phage terminase large subunit; Region: Terminase_3; cl12054 224326000398 Terminase-like family; Region: Terminase_6; pfam03237 224326000399 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 224326000400 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000401 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326000402 Predicted helicase [General function prediction only]; Region: COG4889 224326000403 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326000404 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 224326000405 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 224326000406 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 224326000407 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 224326000408 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 224326000409 active site 224326000410 substrate binding site [chemical binding]; other site 224326000411 metal binding site [ion binding]; metal-binding site 224326000412 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 224326000413 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 224326000414 active site 224326000415 HIGH motif; other site 224326000416 dimer interface [polypeptide binding]; other site 224326000417 KMSKS motif; other site 224326000418 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 224326000419 Domain of unknown function DUF20; Region: UPF0118; pfam01594 224326000420 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 224326000421 TIGR00159 family protein; Region: TIGR00159 224326000422 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 224326000423 YbbR-like protein; Region: YbbR; pfam07949 224326000424 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 224326000425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 224326000426 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 224326000427 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 224326000428 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 224326000429 dimerization interface 3.5A [polypeptide binding]; other site 224326000430 active site 224326000431 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 224326000432 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 224326000433 primosomal protein N'; Region: priA; TIGR00595 224326000434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 224326000435 ATP binding site [chemical binding]; other site 224326000436 putative Mg++ binding site [ion binding]; other site 224326000437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326000438 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 224326000439 ATP-binding site [chemical binding]; other site 224326000440 Sugar specificity; other site 224326000441 Pyrimidine base specificity; other site 224326000442 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 224326000443 active site residue [active] 224326000444 Uncharacterized conserved protein [Function unknown]; Region: COG1284 224326000445 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 224326000446 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 224326000447 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 224326000448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326000449 Walker A motif; other site 224326000450 ATP binding site [chemical binding]; other site 224326000451 Walker B motif; other site 224326000452 arginine finger; other site 224326000453 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 224326000454 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK13901 224326000455 RuvA N terminal domain; Region: RuvA_N; pfam01330 224326000456 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 224326000457 KIAA1430 homologue; Region: KIAA1430; pfam13879 224326000458 Transcriptional regulator; Region: Transcrip_reg; cl00361 224326000459 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 224326000460 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 224326000461 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 224326000462 homodimer interface [polypeptide binding]; other site 224326000463 NADP binding site [chemical binding]; other site 224326000464 substrate binding site [chemical binding]; other site 224326000465 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 224326000466 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 224326000467 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 224326000468 Catalytic site [active] 224326000469 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 224326000470 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 224326000471 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 224326000472 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 224326000473 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 224326000474 SmpB-tmRNA interface; other site 224326000475 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 224326000476 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 224326000477 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 224326000478 CAP-like domain; other site 224326000479 active site 224326000480 primary dimer interface [polypeptide binding]; other site 224326000481 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 224326000482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 224326000483 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 224326000484 anchoring element; other site 224326000485 dimer interface [polypeptide binding]; other site 224326000486 ATP binding site [chemical binding]; other site 224326000487 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 224326000488 active site 224326000489 putative metal-binding site [ion binding]; other site 224326000490 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 224326000491 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 224326000492 putative acyl-acceptor binding pocket; other site 224326000493 PPIC-type PPIASE domain; Region: Rotamase; cl08278 224326000494 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 224326000495 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 224326000496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326000497 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 224326000498 PhoU domain; Region: PhoU; pfam01895 224326000499 PhoU domain; Region: PhoU; pfam01895 224326000500 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 224326000501 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 224326000502 Walker A/P-loop; other site 224326000503 ATP binding site [chemical binding]; other site 224326000504 RecF/RecN/SMC N terminal domain; Region: SMC_N; pfam02463 224326000505 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 224326000506 ABC transporter signature motif; other site 224326000507 Walker B; other site 224326000508 D-loop; other site 224326000509 H-loop/switch region; other site 224326000510 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 224326000511 RNA/DNA hybrid binding site [nucleotide binding]; other site 224326000512 active site 224326000513 Protein of unknown function (DUF3276); Region: DUF3276; cl15305 224326000514 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 224326000515 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 224326000516 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 224326000517 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 224326000518 ligand binding site [chemical binding]; other site 224326000519 active site 224326000520 UGI interface [polypeptide binding]; other site 224326000521 catalytic site [active] 224326000522 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 224326000523 substrate binding site [chemical binding]; other site 224326000524 dimer interface [polypeptide binding]; other site 224326000525 catalytic triad [active] 224326000526 Phosphoglycerate kinase; Region: PGK; pfam00162 224326000527 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 224326000528 substrate binding site [chemical binding]; other site 224326000529 hinge regions; other site 224326000530 ADP binding site [chemical binding]; other site 224326000531 catalytic site [active] 224326000532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326000533 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 224326000534 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 224326000535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000536 binding surface 224326000537 Tetratricopeptide repeat; Region: TPR_16; pfam13432 224326000538 TPR motif; other site 224326000539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 224326000540 TPR motif; other site 224326000541 binding surface 224326000542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000543 binding surface 224326000544 TPR motif; other site 224326000545 TPR repeat; Region: TPR_11; pfam13414 224326000546 FOG: CBS domain [General function prediction only]; Region: COG0517 224326000547 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 224326000548 Transporter associated domain; Region: CorC_HlyC; cl08393 224326000549 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 224326000550 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 224326000551 catalytic residues [active] 224326000552 RNA methyltransferase, RsmE family; Region: TIGR00046 224326000553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 224326000554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 224326000555 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 224326000556 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 224326000557 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 224326000558 methionyl-tRNA formyltransferase; Region: fmt; TIGR00460 224326000559 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 224326000560 putative active site [active] 224326000561 substrate binding site [chemical binding]; other site 224326000562 putative cosubstrate binding site; other site 224326000563 catalytic site [active] 224326000564 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 224326000565 substrate binding site [chemical binding]; other site 224326000566 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 224326000567 active site 224326000568 catalytic residues [active] 224326000569 metal binding site [ion binding]; metal-binding site 224326000570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 224326000571 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 224326000572 active site 224326000573 motif I; other site 224326000574 motif II; other site 224326000575 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 224326000576 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 224326000577 Divergent PAP2 family; Region: DUF212; cl00855 224326000578 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 224326000579 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 224326000580 peptide chain release factor 2; Validated; Region: prfB; PRK00578 224326000581 RF-1 domain; Region: RF-1; cl02875 224326000582 RF-1 domain; Region: RF-1; cl02875 224326000583 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 224326000584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326000585 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 224326000586 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 224326000587 Walker A/P-loop; other site 224326000588 ATP binding site [chemical binding]; other site 224326000589 Q-loop/lid; other site 224326000590 ABC transporter signature motif; other site 224326000591 Walker B; other site 224326000592 D-loop; other site 224326000593 H-loop/switch region; other site 224326000594 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 224326000595 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 224326000596 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 224326000597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 224326000598 catalytic residue [active] 224326000599 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 224326000600 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 224326000601 active site 224326000602 trimerization site [polypeptide binding]; other site 224326000603 Mg chelatase-related protein; Region: TIGR00368 224326000604 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 224326000605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326000606 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 224326000607 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 224326000608 tetramer (dimer of dimers) interface [polypeptide binding]; other site 224326000609 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 224326000610 NAD binding site [chemical binding]; other site 224326000611 dimer interface [polypeptide binding]; other site 224326000612 substrate binding site [chemical binding]; other site 224326000613 GTP-binding protein LepA; Provisional; Region: PRK05433 224326000614 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 224326000615 Switch I region; other site 224326000616 G2 box; other site 224326000617 putative GEF interaction site [polypeptide binding]; other site 224326000618 G3 box; other site 224326000619 Switch II region; other site 224326000620 GTP/Mg2+ binding site [chemical binding]; other site 224326000621 G4 box; other site 224326000622 G5 box; other site 224326000623 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 224326000624 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 224326000625 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 224326000626 V-type ATP synthase subunit K; Validated; Region: PRK06649 224326000627 ATP synthase subunit D; Region: ATP-synt_D; cl00613 224326000628 V-type ATP synthase subunit B; Provisional; Region: PRK02118 224326000629 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 224326000630 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 224326000631 Walker A motif homologous position; other site 224326000632 Walker B motif; other site 224326000633 Plant ATP synthase F0; Region: YMF19; cl07975 224326000634 MutS2 family protein; Region: mutS2; TIGR01069 224326000635 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 224326000636 Walker A/P-loop; other site 224326000637 ATP binding site [chemical binding]; other site 224326000638 Q-loop/lid; other site 224326000639 ABC transporter signature motif; other site 224326000640 Walker B; other site 224326000641 D-loop; other site 224326000642 H-loop/switch region; other site 224326000643 Smr domain; Region: Smr; cl02619 224326000644 ribosome small subunit-dependent GTPase A; Region: TIGR00157 224326000645 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 224326000646 GTPase/Zn-binding domain interface [polypeptide binding]; other site 224326000647 GTP/Mg2+ binding site [chemical binding]; other site 224326000648 G4 box; other site 224326000649 G5 box; other site 224326000650 G1 box; other site 224326000651 Switch I region; other site 224326000652 G2 box; other site 224326000653 G3 box; other site 224326000654 Switch II region; other site 224326000655 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 224326000656 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 224326000657 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 224326000658 putative dimer interface [polypeptide binding]; other site 224326000659 putative anticodon binding site; other site 224326000660 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 224326000661 homodimer interface [polypeptide binding]; other site 224326000662 motif 1; other site 224326000663 motif 2; other site 224326000664 active site 224326000665 motif 3; other site 224326000666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 224326000667 active site 224326000668 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 224326000669 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 224326000670 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 224326000671 protein binding site [polypeptide binding]; other site 224326000672 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 224326000673 protein binding site [polypeptide binding]; other site 224326000674 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 224326000675 active site 224326000676 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 224326000677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000678 binding surface 224326000679 TPR motif; other site 224326000680 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 224326000681 putative RNA binding site [nucleotide binding]; other site 224326000682 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 224326000683 SurA N-terminal domain; Region: SurA_N_3; cl07813 224326000684 PPIC-type PPIASE domain; Region: Rotamase; cl08278 224326000685 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 224326000686 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 224326000687 dimer interface [polypeptide binding]; other site 224326000688 active site 224326000689 replicative DNA helicase; Region: DnaB; TIGR00665 224326000690 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 224326000691 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 224326000692 Walker A motif; other site 224326000693 ATP binding site [chemical binding]; other site 224326000694 Walker B motif; other site 224326000695 DNA binding loops [nucleotide binding] 224326000696 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 224326000697 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 224326000698 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 224326000699 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 224326000700 dimer interface [polypeptide binding]; other site 224326000701 ssDNA binding site [nucleotide binding]; other site 224326000702 tetramer (dimer of dimers) interface [polypeptide binding]; other site 224326000703 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 224326000704 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 224326000705 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 224326000706 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 224326000707 active site turn [active] 224326000708 phosphorylation site [posttranslational modification] 224326000709 Haemolysin-III related; Region: HlyIII; cl03831 224326000710 RIP metalloprotease RseP; Region: TIGR00054 224326000711 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 224326000712 active site 224326000713 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 224326000714 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 224326000715 protein binding site [polypeptide binding]; other site 224326000716 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 224326000717 putative substrate binding region [chemical binding]; other site 224326000718 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 224326000719 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 224326000720 catalytic residue [active] 224326000721 putative FPP diphosphate binding site; other site 224326000722 putative FPP binding hydrophobic cleft; other site 224326000723 dimer interface [polypeptide binding]; other site 224326000724 putative IPP diphosphate binding site; other site 224326000725 ribosome recycling factor; Reviewed; Region: frr; PRK00083 224326000726 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 224326000727 hinge region; other site 224326000728 translation elongation factor Ts; Region: tsf; TIGR00116 224326000729 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 224326000730 Elongation factor TS; Region: EF_TS; pfam00889 224326000731 Elongation factor TS; Region: EF_TS; pfam00889 224326000732 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 224326000733 rRNA interaction site [nucleotide binding]; other site 224326000734 S8 interaction site; other site 224326000735 putative laminin-1 binding site; other site 224326000736 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 224326000737 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 224326000738 RNA binding site [nucleotide binding]; other site 224326000739 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 224326000740 RNA binding site [nucleotide binding]; other site 224326000741 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 224326000742 RNA binding site [nucleotide binding]; other site 224326000743 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 224326000744 RNA binding site [nucleotide binding]; other site 224326000745 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 224326000746 cytidylate kinase; Region: cmk; TIGR00017 224326000747 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 224326000748 CMP-binding site; other site 224326000749 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 224326000750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 224326000751 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 224326000752 active site 224326000753 ScpA/B protein; Region: ScpA_ScpB; cl00598 224326000754 recombinase A; Provisional; Region: recA; PRK09354 224326000755 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 224326000756 hexamer interface [polypeptide binding]; other site 224326000757 Walker A motif; other site 224326000758 ATP binding site [chemical binding]; other site 224326000759 Walker B motif; other site 224326000760 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 224326000761 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 224326000762 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 224326000763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000764 binding surface 224326000765 TPR motif; other site 224326000766 Tetratricopeptide repeat; Region: TPR_16; pfam13432 224326000767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000768 TPR motif; other site 224326000769 binding surface 224326000770 histidyl-tRNA synthetase; Region: hisS; TIGR00442 224326000771 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 224326000772 dimer interface [polypeptide binding]; other site 224326000773 motif 1; other site 224326000774 active site 224326000775 motif 2; other site 224326000776 motif 3; other site 224326000777 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 224326000778 anticodon binding site; other site 224326000779 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 224326000780 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 224326000781 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 224326000782 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 224326000783 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 224326000784 AMP-binding enzyme; Region: AMP-binding; cl15778 224326000785 AMP-binding enzyme; Region: AMP-binding; cl15778 224326000786 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 224326000787 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 224326000788 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 224326000789 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 224326000790 Haemolytic domain; Region: Haemolytic; cl00506 224326000791 NMT1-like family; Region: NMT1_2; cl15260 224326000792 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 224326000793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 224326000794 dimer interface [polypeptide binding]; other site 224326000795 conserved gate region; other site 224326000796 putative PBP binding loops; other site 224326000797 ABC-ATPase subunit interface; other site 224326000798 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 224326000799 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 224326000800 Walker A/P-loop; other site 224326000801 ATP binding site [chemical binding]; other site 224326000802 Q-loop/lid; other site 224326000803 ABC transporter signature motif; other site 224326000804 Walker B; other site 224326000805 D-loop; other site 224326000806 H-loop/switch region; other site 224326000807 flagellin; Provisional; Region: PRK12803 224326000808 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 224326000809 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 224326000810 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 224326000811 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 224326000812 active site 224326000813 dimer interface [polypeptide binding]; other site 224326000814 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 224326000815 active site 224326000816 trimer interface [polypeptide binding]; other site 224326000817 allosteric site; other site 224326000818 active site lid [active] 224326000819 hexamer (dimer of trimers) interface [polypeptide binding]; other site 224326000820 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 224326000821 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 224326000822 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 224326000823 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 224326000824 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 224326000825 SEC-C motif; Region: SEC-C; pfam02810 224326000826 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 224326000827 alanine racemase; Region: alr; TIGR00492 224326000828 active site 224326000829 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 224326000830 dimer interface [polypeptide binding]; other site 224326000831 substrate binding site [chemical binding]; other site 224326000832 catalytic residues [active] 224326000833 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 224326000834 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 224326000835 Uncharacterized conserved protein [Function unknown]; Region: COG1306 224326000836 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 224326000837 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 224326000838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 224326000839 ligand binding site [chemical binding]; other site 224326000840 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 224326000841 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 224326000842 rRNA binding site [nucleotide binding]; other site 224326000843 predicted 30S ribosome binding site; other site 224326000844 Oxygen tolerance; Region: BatD; pfam13584 224326000845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 224326000846 TPR motif; other site 224326000847 binding surface 224326000848 Bacterial SH3 domain; Region: SH3_3; cl02551 224326000849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000850 binding surface 224326000851 TPR motif; other site 224326000852 TPR repeat; Region: TPR_11; pfam13414 224326000853 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 224326000854 metal ion-dependent adhesion site (MIDAS); other site 224326000855 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 224326000856 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 224326000857 MoxR-like ATPases [General function prediction only]; Region: COG0714 224326000858 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326000859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 224326000860 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 224326000861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326000862 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 224326000863 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 224326000864 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 224326000865 trmE is a tRNA modification GTPase; Region: trmE; cd04164 224326000866 G1 box; other site 224326000867 GTP/Mg2+ binding site [chemical binding]; other site 224326000868 Switch I region; other site 224326000869 G2 box; other site 224326000870 Switch II region; other site 224326000871 G3 box; other site 224326000872 G4 box; other site 224326000873 G5 box; other site 224326000874 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 224326000875 FliW protein; Region: FliW; cl00740 224326000876 Global regulator protein family; Region: CsrA; cl00670 224326000877 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 224326000878 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 224326000879 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 224326000880 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 224326000881 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 224326000882 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 224326000883 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 224326000884 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 224326000885 active site 224326000886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000887 binding surface 224326000888 TPR repeat; Region: TPR_11; pfam13414 224326000889 TPR motif; other site 224326000890 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 224326000891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000892 binding surface 224326000893 TPR motif; other site 224326000894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326000895 binding surface 224326000896 TPR motif; other site 224326000897 Tetratricopeptide repeat; Region: TPR_16; pfam13432 224326000898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 224326000899 S-adenosylmethionine binding site [chemical binding]; other site 224326000900 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 224326000901 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 224326000902 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 224326000903 synthetase active site [active] 224326000904 NTP binding site [chemical binding]; other site 224326000905 metal binding site [ion binding]; metal-binding site 224326000906 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 224326000907 D-alanyl-alanine synthetase A; Provisional; Region: PRK14570 224326000908 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 224326000909 ATP-grasp domain; Region: ATP-grasp_4; cl03087 224326000910 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 224326000911 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 224326000912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 224326000913 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224326000914 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 224326000915 Domain of unknown function DUF21; Region: DUF21; pfam01595 224326000916 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 224326000917 Transporter associated domain; Region: CorC_HlyC; cl08393 224326000918 HflK protein; Region: hflK; TIGR01933 224326000919 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 224326000920 HflC protein; Region: hflC; TIGR01932 224326000921 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 224326000922 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 224326000923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326000924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 224326000925 binding surface 224326000926 TPR motif; other site 224326000927 TPR repeat; Region: TPR_11; pfam13414 224326000928 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 224326000929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 224326000930 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 224326000931 ATP binding site [chemical binding]; other site 224326000932 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 224326000933 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 224326000934 translation elongation factor P; Region: efp; TIGR00038 224326000935 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 224326000936 RNA binding site [nucleotide binding]; other site 224326000937 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 224326000938 RNA binding site [nucleotide binding]; other site 224326000939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 224326000940 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 224326000941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 224326000942 dimer interface [polypeptide binding]; other site 224326000943 conserved gate region; other site 224326000944 putative PBP binding loops; other site 224326000945 ABC-ATPase subunit interface; other site 224326000946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 224326000947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 224326000948 dimer interface [polypeptide binding]; other site 224326000949 conserved gate region; other site 224326000950 putative PBP binding loops; other site 224326000951 ABC-ATPase subunit interface; other site 224326000952 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14273 224326000953 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 224326000954 Walker A/P-loop; other site 224326000955 ATP binding site [chemical binding]; other site 224326000956 Q-loop/lid; other site 224326000957 ABC transporter signature motif; other site 224326000958 Walker B; other site 224326000959 D-loop; other site 224326000960 H-loop/switch region; other site 224326000961 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 224326000962 ZIP Zinc transporter; Region: Zip; pfam02535 224326000963 alanyl-tRNA synthetase; Provisional; Region: PRK01584 224326000964 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 224326000965 motif 1; other site 224326000966 active site 224326000967 motif 2; other site 224326000968 motif 3; other site 224326000969 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 224326000970 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 224326000971 FliG C-terminal domain; Region: FliG_C; pfam01706 224326000972 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 224326000973 putative active site [active] 224326000974 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 224326000975 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 224326000976 FMN binding site [chemical binding]; other site 224326000977 active site 224326000978 catalytic residues [active] 224326000979 substrate binding site [chemical binding]; other site 224326000980 seryl-tRNA synthetase; Region: serS; TIGR00414 224326000981 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 224326000982 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 224326000983 dimer interface [polypeptide binding]; other site 224326000984 active site 224326000985 motif 1; other site 224326000986 motif 2; other site 224326000987 motif 3; other site 224326000988 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 224326000989 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 224326000990 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 224326000991 Peptidase M16C associated; Region: M16C_assoc; pfam08367 224326000992 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 224326000993 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 224326000994 transcription termination factor Rho; Region: rho; TIGR00767 224326000995 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 224326000996 RNA binding site [nucleotide binding]; other site 224326000997 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 224326000998 multimer interface [polypeptide binding]; other site 224326000999 Walker A motif; other site 224326001000 ATP binding site [chemical binding]; other site 224326001001 Walker B motif; other site 224326001002 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 224326001003 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 224326001004 IHF dimer interface [polypeptide binding]; other site 224326001005 IHF - DNA interface [nucleotide binding]; other site 224326001006 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 224326001007 GTP-binding protein YchF; Reviewed; Region: PRK09601 224326001008 YchF GTPase; Region: YchF; cd01900 224326001009 G1 box; other site 224326001010 GTP/Mg2+ binding site [chemical binding]; other site 224326001011 Switch I region; other site 224326001012 G2 box; other site 224326001013 Switch II region; other site 224326001014 G3 box; other site 224326001015 G4 box; other site 224326001016 G5 box; other site 224326001017 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 224326001018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 224326001019 TPR motif; other site 224326001020 binding surface 224326001021 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 224326001022 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 224326001023 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 224326001024 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 224326001025 putative active site [active] 224326001026 catalytic triad [active] 224326001027 putative dimer interface [polypeptide binding]; other site 224326001028 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 224326001029 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 224326001030 Substrate-binding site [chemical binding]; other site 224326001031 Substrate specificity [chemical binding]; other site 224326001032 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 224326001033 amphipathic channel; other site 224326001034 Asn-Pro-Ala signature motifs; other site 224326001035 glycerol kinase; Provisional; Region: glpK; PRK00047 224326001036 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 224326001037 N- and C-terminal domain interface [polypeptide binding]; other site 224326001038 active site 224326001039 MgATP binding site [chemical binding]; other site 224326001040 catalytic site [active] 224326001041 metal binding site [ion binding]; metal-binding site 224326001042 glycerol binding site [chemical binding]; other site 224326001043 homotetramer interface [polypeptide binding]; other site 224326001044 homodimer interface [polypeptide binding]; other site 224326001045 FBP binding site [chemical binding]; other site 224326001046 protein IIAGlc interface [polypeptide binding]; other site 224326001047 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 224326001048 Protein of unknown function (DUF327); Region: DUF327; cl00753 224326001049 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 224326001050 Peptidase family M23; Region: Peptidase_M23; pfam01551 224326001051 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 224326001052 active site 224326001053 dimerization interface [polypeptide binding]; other site 224326001054 oligoendopeptidase F; Region: pepF; TIGR00181 224326001055 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 224326001056 active site 224326001057 Zn binding site [ion binding]; other site 224326001058 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 224326001059 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 224326001060 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 224326001061 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 224326001062 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 224326001063 HIGH motif; other site 224326001064 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 224326001065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224326001066 active site 224326001067 KMSKS motif; other site 224326001068 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 224326001069 tRNA binding surface [nucleotide binding]; other site 224326001070 Found in ATP-dependent protease La (LON); Region: LON; smart00464 224326001071 ATP-dependent protease La; Region: lon; TIGR00763 224326001072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326001073 Walker A motif; other site 224326001074 ATP binding site [chemical binding]; other site 224326001075 Walker B motif; other site 224326001076 arginine finger; other site 224326001077 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 224326001078 DHH family; Region: DHH; pfam01368 224326001079 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 224326001080 DHHA1 domain; Region: DHHA1; pfam02272 224326001081 Peptidase family M23; Region: Peptidase_M23; pfam01551 224326001082 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 224326001083 Bacitracin resistance protein BacA; Region: BacA; cl00858 224326001084 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 224326001085 N-acetyl-D-glucosamine binding site [chemical binding]; other site 224326001086 catalytic residue [active] 224326001087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326001088 binding surface 224326001089 TPR motif; other site 224326001090 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 224326001091 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 224326001092 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 224326001093 putative peptidoglycan binding site; other site 224326001094 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 224326001095 putative peptidoglycan binding site; other site 224326001096 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 224326001097 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 224326001098 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 224326001099 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 224326001100 ATP binding site [chemical binding]; other site 224326001101 profilin binding site; other site 224326001102 Uncharacterized conserved protein [Function unknown]; Region: COG1315 224326001103 Integral peroxisomal membrane peroxin; Region: Pex24p; pfam06398 224326001104 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 224326001105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001106 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 224326001107 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 224326001108 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001110 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 224326001111 FHIPEP family; Region: FHIPEP; pfam00771 224326001112 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 224326001113 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 224326001114 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 224326001115 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 224326001116 FliP family; Region: FliP; cl00593 224326001117 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 224326001118 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 224326001119 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 224326001120 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 224326001121 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 224326001122 flagellar motor protein MotB; Validated; Region: motB; PRK06667 224326001123 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 224326001124 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 224326001125 ligand binding site [chemical binding]; other site 224326001126 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 224326001127 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 224326001128 Flagellar protein (FlbD); Region: FlbD; cl00683 224326001129 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 224326001130 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 224326001131 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 224326001132 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 224326001133 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 224326001134 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 224326001135 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 224326001136 ATPase FliI/YscN family; Region: fliI_yscN; TIGR01026 224326001137 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 224326001138 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 224326001139 Walker A motif/ATP binding site; other site 224326001140 Walker B motif; other site 224326001141 flagellar assembly protein H; Validated; Region: fliH; PRK06669 224326001142 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 224326001143 Flagellar assembly protein FliH; Region: FliH; pfam02108 224326001144 flagellar motor switch protein FliG; Region: fliG; TIGR00207 224326001145 FliG C-terminal domain; Region: FliG_C; pfam01706 224326001146 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 224326001147 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 224326001148 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 224326001149 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 224326001150 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 224326001151 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 224326001152 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 224326001153 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622 224326001154 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 224326001155 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 224326001156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326001157 Walker A motif; other site 224326001158 ATP binding site [chemical binding]; other site 224326001159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001160 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 224326001161 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 224326001162 active site 224326001163 HslU subunit interaction site [polypeptide binding]; other site 224326001164 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 224326001165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 224326001166 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 224326001167 cell division protein FtsZ; Validated; Region: PRK09330 224326001168 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 224326001169 nucleotide binding site [chemical binding]; other site 224326001170 SulA interaction site; other site 224326001171 cell division protein FtsA; Region: ftsA; TIGR01174 224326001172 Cell division protein FtsA; Region: FtsA; cl11496 224326001173 Cell division protein FtsA; Region: FtsA; cl11496 224326001174 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 224326001175 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 224326001176 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 224326001177 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 224326001178 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 224326001179 Mg++ binding site [ion binding]; other site 224326001180 putative catalytic motif [active] 224326001181 putative substrate binding site [chemical binding]; other site 224326001182 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 224326001183 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 224326001184 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 224326001185 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224326001186 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 224326001187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326001188 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 224326001189 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 224326001190 putative CheA interaction surface; other site 224326001191 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 224326001192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 224326001193 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 224326001194 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 224326001195 substrate binding pocket [chemical binding]; other site 224326001196 chain length determination region; other site 224326001197 substrate-Mg2+ binding site; other site 224326001198 catalytic residues [active] 224326001199 aspartate-rich region 1; other site 224326001200 active site lid residues [active] 224326001201 aspartate-rich region 2; other site 224326001202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 224326001203 binding surface 224326001204 TPR motif; other site 224326001205 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 224326001206 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 224326001207 TM-ABC transporter signature motif; other site 224326001208 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 224326001209 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001210 Walker A/P-loop; other site 224326001211 ATP binding site [chemical binding]; other site 224326001212 Q-loop/lid; other site 224326001213 ABC transporter signature motif; other site 224326001214 Walker B; other site 224326001215 D-loop; other site 224326001216 H-loop/switch region; other site 224326001217 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 224326001218 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 224326001219 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 224326001220 Tetratricopeptide repeat; Region: TPR_16; pfam13432 224326001221 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 224326001222 metal ion-dependent adhesion site (MIDAS); other site 224326001223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326001224 binding surface 224326001225 TPR motif; other site 224326001226 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 224326001227 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 224326001228 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 224326001229 peptide binding site [polypeptide binding]; other site 224326001230 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 224326001231 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 224326001232 peptide binding site [polypeptide binding]; other site 224326001233 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 224326001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 224326001235 dimer interface [polypeptide binding]; other site 224326001236 conserved gate region; other site 224326001237 putative PBP binding loops; other site 224326001238 ABC-ATPase subunit interface; other site 224326001239 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 224326001240 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 224326001241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 224326001242 dimer interface [polypeptide binding]; other site 224326001243 conserved gate region; other site 224326001244 putative PBP binding loops; other site 224326001245 ABC-ATPase subunit interface; other site 224326001246 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 224326001247 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 224326001248 Walker A/P-loop; other site 224326001249 ATP binding site [chemical binding]; other site 224326001250 Q-loop/lid; other site 224326001251 ABC transporter signature motif; other site 224326001252 Walker B; other site 224326001253 D-loop; other site 224326001254 H-loop/switch region; other site 224326001255 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 224326001256 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 224326001257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 224326001258 Walker A/P-loop; other site 224326001259 ATP binding site [chemical binding]; other site 224326001260 Q-loop/lid; other site 224326001261 ABC transporter signature motif; other site 224326001262 Walker B; other site 224326001263 D-loop; other site 224326001264 H-loop/switch region; other site 224326001265 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 224326001266 enolase; Provisional; Region: eno; PRK00077 224326001267 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 224326001268 dimer interface [polypeptide binding]; other site 224326001269 metal binding site [ion binding]; metal-binding site 224326001270 substrate binding pocket [chemical binding]; other site 224326001271 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 224326001272 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 224326001273 23S rRNA interface [nucleotide binding]; other site 224326001274 L3 interface [polypeptide binding]; other site 224326001275 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 224326001276 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 224326001277 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 224326001278 GatB domain; Region: GatB_Yqey; cl11497 224326001279 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 224326001280 Amidase; Region: Amidase; cl11426 224326001281 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 224326001282 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 224326001283 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001284 Family description; Region: UvrD_C_2; cl15862 224326001285 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 224326001286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 224326001287 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 224326001288 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 224326001289 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 224326001290 Domain of unknown function (DUF814); Region: DUF814; pfam05670 224326001291 pyruvate kinase; Region: pyruv_kin; TIGR01064 224326001292 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 224326001293 domain interfaces; other site 224326001294 active site 224326001295 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 224326001296 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 224326001297 RNA methyltransferase, RsmE family; Region: TIGR00046 224326001298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 224326001299 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 224326001300 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 224326001301 P-loop; other site 224326001302 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 224326001303 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 224326001304 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 224326001305 active site 224326001306 dimer interfaces [polypeptide binding]; other site 224326001307 catalytic residues [active] 224326001308 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 224326001309 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 224326001310 oligomer interface [polypeptide binding]; other site 224326001311 putative active site [active] 224326001312 metal binding site [ion binding]; metal-binding site 224326001313 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 224326001314 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 224326001315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326001316 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 224326001317 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 224326001318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326001319 Walker A motif; other site 224326001320 ATP binding site [chemical binding]; other site 224326001321 Walker B motif; other site 224326001322 arginine finger; other site 224326001323 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 224326001325 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 224326001326 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 224326001327 active site 224326001328 HIGH motif; other site 224326001329 dimer interface [polypeptide binding]; other site 224326001330 KMSKS motif; other site 224326001331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 224326001332 RNA binding surface [nucleotide binding]; other site 224326001333 glycyl-tRNA synthetase; Provisional; Region: PRK04173 224326001334 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 224326001335 dimer interface [polypeptide binding]; other site 224326001336 motif 1; other site 224326001337 active site 224326001338 motif 2; other site 224326001339 motif 3; other site 224326001340 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 224326001341 anticodon binding site; other site 224326001342 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 224326001343 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 224326001344 active site 224326001345 HIGH motif; other site 224326001346 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 224326001347 active site 224326001348 KMSKS motif; other site 224326001349 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 224326001350 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 224326001351 S-adenosylmethionine synthetase; Region: metK; TIGR01034 224326001352 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 224326001353 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 224326001354 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 224326001355 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 224326001356 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 224326001357 HIT family signature motif; other site 224326001358 catalytic residue [active] 224326001359 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 224326001360 MgtE intracellular N domain; Region: MgtE_N; cl15244 224326001361 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 224326001362 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 224326001363 Divalent cation transporter; Region: MgtE; cl00786 224326001364 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 224326001365 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 224326001366 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 224326001367 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 224326001368 ligand binding site [chemical binding]; other site 224326001369 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 224326001370 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 224326001371 ligand binding site [chemical binding]; other site 224326001372 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 224326001373 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 224326001374 ligand binding site [chemical binding]; other site 224326001375 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 224326001376 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 224326001377 ligand binding site [chemical binding]; other site 224326001378 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 224326001379 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 224326001380 S17 interaction site [polypeptide binding]; other site 224326001381 S8 interaction site; other site 224326001382 16S rRNA interaction site [nucleotide binding]; other site 224326001383 streptomycin interaction site [chemical binding]; other site 224326001384 23S rRNA interaction site [nucleotide binding]; other site 224326001385 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 224326001386 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 224326001387 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 224326001388 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 224326001389 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 224326001390 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 224326001391 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 224326001392 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 224326001393 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 224326001394 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 224326001395 cleft; other site 224326001396 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 224326001397 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 224326001398 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 224326001399 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 224326001400 DNA binding site [nucleotide binding] 224326001401 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 224326001402 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 224326001403 core dimer interface [polypeptide binding]; other site 224326001404 peripheral dimer interface [polypeptide binding]; other site 224326001405 L10 interface [polypeptide binding]; other site 224326001406 L11 interface [polypeptide binding]; other site 224326001407 putative EF-Tu interaction site [polypeptide binding]; other site 224326001408 putative EF-G interaction site [polypeptide binding]; other site 224326001409 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 224326001410 23S rRNA interface [nucleotide binding]; other site 224326001411 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 224326001412 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 224326001413 mRNA/rRNA interface [nucleotide binding]; other site 224326001414 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 224326001415 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 224326001416 23S rRNA interface [nucleotide binding]; other site 224326001417 L7/L12 interface [polypeptide binding]; other site 224326001418 putative thiostrepton binding site; other site 224326001419 L25 interface [polypeptide binding]; other site 224326001420 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 224326001421 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 224326001422 putative homodimer interface [polypeptide binding]; other site 224326001423 KOW motif; Region: KOW; cl00354 224326001424 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 224326001425 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 224326001426 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 224326001427 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 224326001428 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 224326001429 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 224326001430 prolyl-tRNA synthetase; Provisional; Region: PRK08661 224326001431 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 224326001432 dimer interface [polypeptide binding]; other site 224326001433 motif 1; other site 224326001434 active site 224326001435 motif 2; other site 224326001436 motif 3; other site 224326001437 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 224326001438 anticodon binding site; other site 224326001439 zinc-binding site [ion binding]; other site 224326001440 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 224326001441 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 224326001442 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 224326001443 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 224326001444 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 224326001445 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 224326001446 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 224326001447 active site 224326001448 phosphorylation site [posttranslational modification] 224326001449 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 224326001450 active site 224326001451 P-loop; other site 224326001452 phosphorylation site [posttranslational modification] 224326001453 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 224326001454 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 224326001455 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 224326001456 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 224326001457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326001458 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 224326001459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 224326001460 active site 224326001461 phosphorylation site [posttranslational modification] 224326001462 intermolecular recognition site; other site 224326001463 CheB methylesterase; Region: CheB_methylest; pfam01339 224326001464 TraB family; Region: TraB; cl12050 224326001465 adenylate kinase; Provisional; Region: PRK14526 224326001466 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 224326001467 AMP-binding site [chemical binding]; other site 224326001468 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 224326001469 Response regulator receiver domain; Region: Response_reg; pfam00072 224326001470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 224326001471 active site 224326001472 phosphorylation site [posttranslational modification] 224326001473 intermolecular recognition site; other site 224326001474 dimerization interface [polypeptide binding]; other site 224326001475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 224326001476 metal binding site [ion binding]; metal-binding site 224326001477 active site 224326001478 I-site; other site 224326001479 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 224326001480 substrate binding pocket [chemical binding]; other site 224326001481 membrane-bound complex binding site; other site 224326001482 hinge residues; other site 224326001483 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 224326001484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 224326001485 dimer interface [polypeptide binding]; other site 224326001486 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 224326001487 phosphorylation site [posttranslational modification] 224326001488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 224326001489 ATP binding site [chemical binding]; other site 224326001490 Mg2+ binding site [ion binding]; other site 224326001491 G-X-G motif; other site 224326001492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 224326001493 active site 224326001494 phosphorylation site [posttranslational modification] 224326001495 intermolecular recognition site; other site 224326001496 dimerization interface [polypeptide binding]; other site 224326001497 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 224326001498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 224326001499 active site 224326001500 motif I; other site 224326001501 motif II; other site 224326001502 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 224326001503 active site 224326001504 DNA binding site [nucleotide binding] 224326001505 TIR domain; Region: TIR_2; cl15770 224326001506 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 224326001507 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 224326001508 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 224326001509 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 224326001510 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 224326001511 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326001512 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326001513 P-loop; other site 224326001514 Magnesium ion binding site [ion binding]; other site 224326001515 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326001516 Magnesium ion binding site [ion binding]; other site 224326001517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001518 ParB-like partition proteins; Region: parB_part; TIGR00180 224326001519 ParB-like nuclease domain; Region: ParBc; cl02129 224326001520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 224326001521 DNA gyrase, A subunit; Region: gyrA; TIGR01063 224326001522 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 224326001523 CAP-like domain; other site 224326001524 active site 224326001525 primary dimer interface [polypeptide binding]; other site 224326001526 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224326001527 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224326001528 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224326001529 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224326001530 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 224326001531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 224326001532 ATP binding site [chemical binding]; other site 224326001533 Mg2+ binding site [ion binding]; other site 224326001534 G-X-G motif; other site 224326001535 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 224326001536 anchoring element; other site 224326001537 dimer interface [polypeptide binding]; other site 224326001538 ATP binding site [chemical binding]; other site 224326001539 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 224326001540 active site 224326001541 putative metal-binding site [ion binding]; other site 224326001542 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 224326001543 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 224326001544 DnaA N-terminal domain; Region: DnaA_N; pfam11638 224326001545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326001546 Walker A motif; other site 224326001547 ATP binding site [chemical binding]; other site 224326001548 Walker B motif; other site 224326001549 arginine finger; other site 224326001550 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 224326001551 DnaA box-binding interface [nucleotide binding]; other site 224326001552 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 224326001553 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 224326001554 putative DNA binding surface [nucleotide binding]; other site 224326001555 dimer interface [polypeptide binding]; other site 224326001556 beta-clamp/clamp loader binding surface; other site 224326001557 beta-clamp/translesion DNA polymerase binding surface; other site 224326001558 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 224326001559 Ribonuclease P; Region: Ribonuclease_P; cl00457 224326001560 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 224326001561 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 224326001562 G-X-X-G motif; other site 224326001563 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 224326001564 RxxxH motif; other site 224326001565 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 224326001566 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 224326001567 putative NAD(P) binding site [chemical binding]; other site 224326001568 active site 224326001569 putative substrate binding site [chemical binding]; other site 224326001570 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 224326001571 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 224326001572 active site 224326001573 intersubunit interface [polypeptide binding]; other site 224326001574 zinc binding site [ion binding]; other site 224326001575 Na+ binding site [ion binding]; other site 224326001576 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 224326001577 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 224326001578 dimer interface [polypeptide binding]; other site 224326001579 anticodon binding site; other site 224326001580 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 224326001581 homodimer interface [polypeptide binding]; other site 224326001582 motif 1; other site 224326001583 active site 224326001584 motif 2; other site 224326001585 GAD domain; Region: GAD; pfam02938 224326001586 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 224326001587 motif 3; other site 224326001588 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 224326001589 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 224326001590 Sexual stage antigen s48/45 domain; Region: s48_45; cl15295 224326001591 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 224326001592 active site 224326001593 phosphorylation site [posttranslational modification] 224326001594 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 224326001595 dimerization domain swap beta strand [polypeptide binding]; other site 224326001596 regulatory protein interface [polypeptide binding]; other site 224326001597 active site 224326001598 regulatory phosphorylation site [posttranslational modification]; other site 224326001599 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 224326001600 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 224326001601 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 224326001602 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 224326001603 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 224326001604 Chromate transporter; Region: Chromate_transp; pfam02417 224326001605 Chromate transporter; Region: Chromate_transp; pfam02417 224326001606 Mechanosensitive ion channel; Region: MS_channel; pfam00924 224326001607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 224326001608 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 224326001609 putative ADP-binding pocket [chemical binding]; other site 224326001610 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 224326001611 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14670 224326001612 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 224326001613 active site 224326001614 catalytic site [active] 224326001615 putative DNA binding site [nucleotide binding]; other site 224326001616 GIY-YIG motif/motif A; other site 224326001617 metal binding site [ion binding]; metal-binding site 224326001618 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 224326001619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326001620 binding surface 224326001621 TPR motif; other site 224326001622 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647 224326001623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326001624 Walker A motif; other site 224326001625 ATP binding site [chemical binding]; other site 224326001626 Walker B motif; other site 224326001627 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326001628 arginine finger; other site 224326001629 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 224326001630 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 224326001631 active site 224326001632 multimer interface [polypeptide binding]; other site 224326001633 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 224326001634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 224326001635 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 224326001636 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 224326001637 Walker A/P-loop; other site 224326001638 ATP binding site [chemical binding]; other site 224326001639 Q-loop/lid; other site 224326001640 ABC transporter signature motif; other site 224326001641 Walker B; other site 224326001642 D-loop; other site 224326001643 H-loop/switch region; other site 224326001644 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 224326001645 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 224326001646 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 224326001647 Uncharacterized conserved protein [Function unknown]; Region: COG0327 224326001648 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 224326001649 lipoprotein signal peptidase; Provisional; Region: PRK14787 224326001650 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 224326001651 active site 224326001652 metal binding site [ion binding]; metal-binding site 224326001653 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 224326001654 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 224326001655 hinge; other site 224326001656 active site 224326001657 putative efflux protein, MATE family; Region: matE; TIGR00797 224326001658 MatE; Region: MatE; cl10513 224326001659 MatE; Region: MatE; cl10513 224326001660 elongation factor Tu; Reviewed; Region: PRK00049 224326001661 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 224326001662 G1 box; other site 224326001663 GEF interaction site [polypeptide binding]; other site 224326001664 GTP/Mg2+ binding site [chemical binding]; other site 224326001665 Switch I region; other site 224326001666 G2 box; other site 224326001667 G3 box; other site 224326001668 Switch II region; other site 224326001669 G4 box; other site 224326001670 G5 box; other site 224326001671 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 224326001672 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 224326001673 Antibiotic Binding Site [chemical binding]; other site 224326001674 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 224326001675 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 224326001676 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 224326001677 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 224326001678 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 224326001679 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 224326001680 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 224326001681 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 224326001682 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 224326001683 putative translocon binding site; other site 224326001684 protein-rRNA interface [nucleotide binding]; other site 224326001685 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 224326001686 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 224326001687 G-X-X-G motif; other site 224326001688 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 224326001689 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 224326001690 23S rRNA interface [nucleotide binding]; other site 224326001691 5S rRNA interface [nucleotide binding]; other site 224326001692 putative antibiotic binding site [chemical binding]; other site 224326001693 L25 interface [polypeptide binding]; other site 224326001694 L27 interface [polypeptide binding]; other site 224326001695 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 224326001696 23S rRNA interface [nucleotide binding]; other site 224326001697 putative translocon interaction site; other site 224326001698 signal recognition particle (SRP54) interaction site; other site 224326001699 L23 interface [polypeptide binding]; other site 224326001700 trigger factor interaction site; other site 224326001701 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 224326001702 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 224326001703 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 224326001704 KOW motif; Region: KOW; cl00354 224326001705 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 224326001706 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 224326001707 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 224326001708 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 224326001709 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 224326001710 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 224326001711 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 224326001712 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 224326001713 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 224326001714 5S rRNA interface [nucleotide binding]; other site 224326001715 23S rRNA interface [nucleotide binding]; other site 224326001716 L5 interface [polypeptide binding]; other site 224326001717 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 224326001718 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 224326001719 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 224326001720 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30_like; cl00203 224326001721 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 224326001722 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 224326001723 SecY translocase; Region: SecY; pfam00344 224326001724 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 224326001725 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 224326001726 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 224326001727 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 224326001728 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 224326001729 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 224326001730 alphaNTD - beta interaction site [polypeptide binding]; other site 224326001731 alphaNTD homodimer interface [polypeptide binding]; other site 224326001732 alphaNTD - beta' interaction site [polypeptide binding]; other site 224326001733 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 224326001734 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 224326001735 phosphodiesterase; Provisional; Region: PRK12704 224326001736 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 224326001737 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 224326001738 Zn2+ binding site [ion binding]; other site 224326001739 Mg2+ binding site [ion binding]; other site 224326001740 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 224326001741 putative active site [active] 224326001742 metal binding site [ion binding]; metal-binding site 224326001743 homodimer binding site [polypeptide binding]; other site 224326001744 Spore germination protein [General function prediction only]; Region: COG5401 224326001745 Sporulation and spore germination; Region: Germane; cl11253 224326001746 GTP-binding protein Der; Reviewed; Region: PRK00093 224326001747 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 224326001748 G1 box; other site 224326001749 GTP/Mg2+ binding site [chemical binding]; other site 224326001750 Switch I region; other site 224326001751 G2 box; other site 224326001752 Switch II region; other site 224326001753 G3 box; other site 224326001754 G4 box; other site 224326001755 G5 box; other site 224326001756 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 224326001757 G1 box; other site 224326001758 GTP/Mg2+ binding site [chemical binding]; other site 224326001759 Switch I region; other site 224326001760 G2 box; other site 224326001761 G3 box; other site 224326001762 Switch II region; other site 224326001763 G4 box; other site 224326001764 G5 box; other site 224326001765 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 224326001766 AAA domain; Region: AAA_13; pfam13166 224326001767 V-type ATP synthase subunit I; Validated; Region: PRK05771 224326001768 chromosome segregation protein; Provisional; Region: PRK03918 224326001769 phenylalanyl-tRNA synthetase, beta subunit; Region: pheT_arch; TIGR00471 224326001770 B3/4 domain; Region: B3_4; cl11458 224326001771 tRNA synthetase B5 domain; Region: B5; cl08394 224326001772 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 224326001773 motif 1; other site 224326001774 dimer interface [polypeptide binding]; other site 224326001775 active site 224326001776 motif 2; other site 224326001777 motif 3; other site 224326001778 chaperone protein DnaJ; Provisional; Region: PRK14285 224326001779 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 224326001780 HSP70 interaction site [polypeptide binding]; other site 224326001781 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 224326001782 Zn binding sites [ion binding]; other site 224326001783 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 224326001784 dimer interface [polypeptide binding]; other site 224326001785 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 224326001786 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 224326001787 dimer interface [polypeptide binding]; other site 224326001788 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 224326001789 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 224326001790 active site 224326001791 Type III pantothenate kinase; Region: Pan_kinase; cl09130 224326001792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 224326001793 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 224326001794 active site 224326001795 catalytic tetrad [active] 224326001796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 224326001797 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 224326001798 active site 224326001799 putative catalytic site [active] 224326001800 phosphate binding site A [ion binding]; other site 224326001801 DNA binding site [nucleotide binding] 224326001802 metal binding site A [ion binding]; metal-binding site 224326001803 putative AP binding site [nucleotide binding]; other site 224326001804 putative metal binding site B [ion binding]; other site 224326001805 phosphate binding site B [ion binding]; other site 224326001806 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 224326001807 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 224326001808 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 224326001809 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 224326001810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326001811 binding surface 224326001812 TPR motif; other site 224326001813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326001814 binding surface 224326001815 TPR motif; other site 224326001816 TPR repeat; Region: TPR_11; pfam13414 224326001817 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 224326001818 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 224326001819 translation elongation factor EF-G; Region: EF-G; TIGR00484 224326001820 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 224326001821 G1 box; other site 224326001822 putative GEF interaction site [polypeptide binding]; other site 224326001823 GTP/Mg2+ binding site [chemical binding]; other site 224326001824 Switch I region; other site 224326001825 G2 box; other site 224326001826 G3 box; other site 224326001827 Switch II region; other site 224326001828 G4 box; other site 224326001829 G5 box; other site 224326001830 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 224326001831 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 224326001832 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 224326001833 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 224326001834 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 224326001835 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 224326001836 active site 224326001837 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 224326001838 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 224326001839 N- and C-terminal domain interface [polypeptide binding]; other site 224326001840 active site 224326001841 MgATP binding site [chemical binding]; other site 224326001842 catalytic site [active] 224326001843 metal binding site [ion binding]; metal-binding site 224326001844 carbohydrate binding site [chemical binding]; other site 224326001845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 224326001846 Sporulation related domain; Region: SPOR; cl10051 224326001847 dephospho-CoA kinase; Region: TIGR00152 224326001848 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 224326001849 CoA-binding site [chemical binding]; other site 224326001850 ATP-binding [chemical binding]; other site 224326001851 DNA polymerase I; Region: pola; TIGR00593 224326001852 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 224326001853 active site 224326001854 metal binding site 1 [ion binding]; metal-binding site 224326001855 putative 5' ssDNA interaction site; other site 224326001856 metal binding site 3; metal-binding site 224326001857 metal binding site 2 [ion binding]; metal-binding site 224326001858 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 224326001859 putative DNA binding site [nucleotide binding]; other site 224326001860 putative metal binding site [ion binding]; other site 224326001861 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 224326001862 active site 224326001863 catalytic site [active] 224326001864 substrate binding site [chemical binding]; other site 224326001865 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 224326001866 active site 224326001867 DNA binding site [nucleotide binding] 224326001868 catalytic site [active] 224326001869 Flagellar protein FliS; Region: FliS; cl00654 224326001870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 224326001871 Response regulator receiver domain; Region: Response_reg; pfam00072 224326001872 active site 224326001873 phosphorylation site [posttranslational modification] 224326001874 intermolecular recognition site; other site 224326001875 dimerization interface [polypeptide binding]; other site 224326001876 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350 224326001877 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 224326001878 nucleotide binding pocket [chemical binding]; other site 224326001879 K-X-D-G motif; other site 224326001880 catalytic site [active] 224326001881 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 224326001882 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 224326001883 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 224326001884 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 224326001885 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 224326001886 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 224326001887 dimerization domain swap beta strand [polypeptide binding]; other site 224326001888 regulatory protein interface [polypeptide binding]; other site 224326001889 active site 224326001890 regulatory phosphorylation site [posttranslational modification]; other site 224326001891 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 224326001892 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 224326001893 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 224326001894 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 224326001895 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 224326001896 HPr interaction site; other site 224326001897 glycerol kinase (GK) interaction site [polypeptide binding]; other site 224326001898 active site 224326001899 phosphorylation site [posttranslational modification] 224326001900 heat shock protein 90; Provisional; Region: PRK05218 224326001901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 224326001902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326001903 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 224326001904 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 224326001905 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 224326001906 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 224326001907 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 224326001908 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 224326001909 putative CheA interaction surface; other site 224326001910 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 224326001911 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 224326001912 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 224326001913 putative binding surface; other site 224326001914 active site 224326001915 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 224326001916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 224326001917 ATP binding site [chemical binding]; other site 224326001918 Mg2+ binding site [ion binding]; other site 224326001919 G-X-G motif; other site 224326001920 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 224326001921 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 224326001922 CheB methylesterase; Region: CheB_methylest; pfam01339 224326001923 chromosome segregation protein; Provisional; Region: PRK01156 224326001924 Response regulator receiver domain; Region: Response_reg; pfam00072 224326001925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 224326001926 active site 224326001927 phosphorylation site [posttranslational modification] 224326001928 intermolecular recognition site; other site 224326001929 dimerization interface [polypeptide binding]; other site 224326001930 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 224326001931 nucleotide binding site [chemical binding]; other site 224326001932 homodimeric interface [polypeptide binding]; other site 224326001933 uridine monophosphate binding site [chemical binding]; other site 224326001934 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 224326001935 active site 224326001936 CTP synthase; Region: PyrG; TIGR00337 224326001937 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 224326001938 Catalytic site [active] 224326001939 active site 224326001940 UTP binding site [chemical binding]; other site 224326001941 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 224326001942 active site 224326001943 putative oxyanion hole; other site 224326001944 catalytic triad [active] 224326001945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 224326001946 putative CheW interface [polypeptide binding]; other site 224326001947 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 224326001948 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 224326001949 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 224326001950 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 224326001951 generic binding surface I; other site 224326001952 generic binding surface II; other site 224326001953 YGGT family; Region: YGGT; cl00508 224326001954 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 224326001955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 224326001956 ATP binding site [chemical binding]; other site 224326001957 putative Mg++ binding site [ion binding]; other site 224326001958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 224326001959 nucleotide binding region [chemical binding]; other site 224326001960 ATP-binding site [chemical binding]; other site 224326001961 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 224326001962 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 224326001963 putative efflux protein, MATE family; Region: matE; TIGR00797 224326001964 MatE; Region: MatE; cl10513 224326001965 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 224326001966 MatE; Region: MatE; cl10513 224326001967 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 224326001968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326001969 NAD(P) binding site [chemical binding]; other site 224326001970 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 224326001971 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224326001972 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 224326001973 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 224326001974 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 224326001975 active site 224326001976 HIGH motif; other site 224326001977 KMSKS motif; other site 224326001978 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 224326001979 tRNA binding surface [nucleotide binding]; other site 224326001980 anticodon binding site; other site 224326001981 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 224326001982 putative tRNA-binding site [nucleotide binding]; other site 224326001983 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 224326001984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326001985 Competence protein; Region: Competence; cl00471 224326001986 CAAX protease self-immunity; Region: Abi; cl00558 224326001987 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 224326001988 AMP-binding enzyme; Region: AMP-binding; cl15778 224326001989 AMP-binding enzyme; Region: AMP-binding; cl15778 224326001990 arginyl-tRNA synthetase; Region: argS; TIGR00456 224326001991 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 224326001992 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 224326001993 active site 224326001994 HIGH motif; other site 224326001995 KMSK motif region; other site 224326001996 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 224326001997 tRNA binding surface [nucleotide binding]; other site 224326001998 anticodon binding site; other site 224326001999 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 224326002000 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 224326002001 dimer interface [polypeptide binding]; other site 224326002002 putative CheW interface [polypeptide binding]; other site 224326002003 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 224326002004 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 224326002005 putative CheW interface [polypeptide binding]; other site 224326002006 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14650 224326002007 FAD binding domain; Region: FAD_binding_4; pfam01565 224326002008 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 224326002009 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14534 224326002010 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224326002011 active site 224326002012 HIGH motif; other site 224326002013 nucleotide binding site [chemical binding]; other site 224326002014 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 224326002015 KMSKS motif; other site 224326002016 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 224326002017 tRNA binding surface [nucleotide binding]; other site 224326002018 anticodon binding site; other site 224326002019 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 224326002020 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 224326002021 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 224326002022 dimer interface [polypeptide binding]; other site 224326002023 active site 224326002024 glycine-pyridoxal phosphate binding site [chemical binding]; other site 224326002025 folate binding site [chemical binding]; other site 224326002026 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 224326002027 HSP70 interaction site [polypeptide binding]; other site 224326002028 Borrelia burgdorferi attachment protein P66; Region: Attachment_P66; pfam11263 224326002029 L-lactate permease; Region: Lactate_perm; cl00701 224326002030 glycolate transporter; Provisional; Region: PRK09695 224326002031 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 224326002032 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 224326002033 CheD chemotactic sensory transduction; Region: CheD; cl00810 224326002034 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 224326002035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002036 Family description; Region: UvrD_C_2; cl15862 224326002037 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 224326002038 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 224326002039 metal binding site [ion binding]; metal-binding site 224326002040 dimer interface [polypeptide binding]; other site 224326002041 trigger factor; Provisional; Region: tig; PRK01490 224326002042 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 224326002043 Clp protease; Region: CLP_protease; pfam00574 224326002044 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 224326002045 oligomer interface [polypeptide binding]; other site 224326002046 active site residues [active] 224326002047 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 224326002048 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 224326002049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326002050 Walker A motif; other site 224326002051 ATP binding site [chemical binding]; other site 224326002052 Walker B motif; other site 224326002053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 224326002054 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 224326002055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326002056 Walker A motif; other site 224326002057 ATP binding site [chemical binding]; other site 224326002058 Walker B motif; other site 224326002059 arginine finger; other site 224326002060 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 224326002061 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 224326002062 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 224326002063 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 224326002064 RNA binding surface [nucleotide binding]; other site 224326002065 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 224326002066 Cation efflux family; Region: Cation_efflux; cl00316 224326002067 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 224326002068 active site 224326002069 catalytic motif [active] 224326002070 Zn binding site [ion binding]; other site 224326002071 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 224326002072 DHH family; Region: DHH; pfam01368 224326002073 DHHA1 domain; Region: DHHA1; pfam02272 224326002074 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 224326002075 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 224326002076 DJ-1 family protein; Region: not_thiJ; TIGR01383 224326002077 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 224326002078 conserved cys residue [active] 224326002079 Acetokinase family; Region: Acetate_kinase; cl01029 224326002080 propionate/acetate kinase; Provisional; Region: PRK12379 224326002081 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 224326002082 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 224326002083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 224326002084 ATP binding site [chemical binding]; other site 224326002085 putative Mg++ binding site [ion binding]; other site 224326002086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 224326002087 nucleotide binding region [chemical binding]; other site 224326002088 ATP-binding site [chemical binding]; other site 224326002089 TRCF domain; Region: TRCF; cl04088 224326002090 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 224326002091 putative peptidoglycan binding site; other site 224326002092 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 224326002093 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 224326002094 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 224326002095 putative peptidoglycan binding site; other site 224326002096 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 224326002097 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 224326002098 putative peptidoglycan binding site; other site 224326002099 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 224326002100 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 224326002101 active site 224326002102 metal binding site [ion binding]; metal-binding site 224326002103 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 224326002104 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 224326002105 putative active site [active] 224326002106 putative metal binding site [ion binding]; other site 224326002107 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 224326002108 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 224326002109 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 224326002110 active site 224326002111 phosphorylation site [posttranslational modification] 224326002112 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 224326002113 active site 224326002114 P-loop; other site 224326002115 phosphorylation site [posttranslational modification] 224326002116 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 224326002117 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 224326002118 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 224326002119 putative substrate binding site [chemical binding]; other site 224326002120 putative ATP binding site [chemical binding]; other site 224326002121 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 224326002122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002123 Family description; Region: UvrD_C_2; cl15862 224326002124 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 224326002125 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 224326002126 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 224326002127 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 224326002128 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 224326002129 active site 224326002130 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 224326002131 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 224326002132 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 224326002133 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 224326002134 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 224326002135 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 224326002136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 224326002137 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 224326002138 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 224326002139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 224326002140 dimer interface [polypeptide binding]; other site 224326002141 conserved gate region; other site 224326002142 putative PBP binding loops; other site 224326002143 ABC-ATPase subunit interface; other site 224326002144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 224326002145 dimer interface [polypeptide binding]; other site 224326002146 conserved gate region; other site 224326002147 putative PBP binding loops; other site 224326002148 ABC-ATPase subunit interface; other site 224326002149 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 224326002150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002151 Walker A/P-loop; other site 224326002152 ATP binding site [chemical binding]; other site 224326002153 Q-loop/lid; other site 224326002154 ABC transporter signature motif; other site 224326002155 Walker B; other site 224326002156 D-loop; other site 224326002157 H-loop/switch region; other site 224326002158 TOBE domain; Region: TOBE_2; cl01440 224326002159 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 224326002160 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 224326002161 GTP/Mg2+ binding site [chemical binding]; other site 224326002162 G4 box; other site 224326002163 G5 box; other site 224326002164 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002165 G1 box; other site 224326002166 G1 box; other site 224326002167 GTP/Mg2+ binding site [chemical binding]; other site 224326002168 Switch I region; other site 224326002169 G2 box; other site 224326002170 G2 box; other site 224326002171 G3 box; other site 224326002172 G3 box; other site 224326002173 Switch II region; other site 224326002174 Switch II region; other site 224326002175 G4 box; other site 224326002176 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 224326002177 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 224326002178 putative active site cavity [active] 224326002179 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 224326002180 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 224326002181 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 224326002182 active site turn [active] 224326002183 phosphorylation site [posttranslational modification] 224326002184 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 224326002185 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 224326002186 metal binding site 2 [ion binding]; metal-binding site 224326002187 putative DNA binding helix; other site 224326002188 metal binding site 1 [ion binding]; metal-binding site 224326002189 structural Zn2+ binding site [ion binding]; other site 224326002190 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 224326002191 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 224326002192 ring oligomerisation interface [polypeptide binding]; other site 224326002193 ATP/Mg binding site [chemical binding]; other site 224326002194 stacking interactions; other site 224326002195 hinge regions; other site 224326002196 Preprotein translocase subunit; Region: YajC; cl00806 224326002197 protein-export membrane protein SecD; Region: secD; TIGR01129 224326002198 Protein export membrane protein; Region: SecD_SecF; cl14618 224326002199 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 224326002200 Protein export membrane protein; Region: SecD_SecF; cl14618 224326002201 chaperone protein DnaJ; Provisional; Region: PRK14299 224326002202 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 224326002203 HSP70 interaction site [polypeptide binding]; other site 224326002204 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 224326002205 substrate binding site [polypeptide binding]; other site 224326002206 dimer interface [polypeptide binding]; other site 224326002207 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 224326002208 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 224326002209 tetramer (dimer of dimers) interface [polypeptide binding]; other site 224326002210 active site 224326002211 dimer interface [polypeptide binding]; other site 224326002212 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 224326002213 catalytic core [active] 224326002214 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 224326002215 lysyl-tRNA synthetase, archaeal and spirochete; Region: lysS_arch; TIGR00467 224326002216 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 224326002217 active site 224326002218 HIGH motif; other site 224326002219 KMSKS motif; other site 224326002220 GTPase Era; Reviewed; Region: era; PRK00089 224326002221 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 224326002222 G1 box; other site 224326002223 GTP/Mg2+ binding site [chemical binding]; other site 224326002224 Switch I region; other site 224326002225 G2 box; other site 224326002226 Switch II region; other site 224326002227 G3 box; other site 224326002228 G4 box; other site 224326002229 G5 box; other site 224326002230 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 224326002231 Double zinc ribbon; Region: DZR; pfam12773 224326002232 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 224326002233 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 224326002234 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 224326002235 active site 224326002236 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 224326002237 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 224326002238 active site 224326002239 metal binding site [ion binding]; metal-binding site 224326002240 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 224326002241 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 224326002242 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 224326002243 putative binding surface; other site 224326002244 active site 224326002245 P2 response regulator binding domain; Region: P2; pfam07194 224326002246 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 224326002247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 224326002248 ATP binding site [chemical binding]; other site 224326002249 Mg2+ binding site [ion binding]; other site 224326002250 G-X-G motif; other site 224326002251 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 224326002252 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 224326002253 putative CheA interaction surface; other site 224326002254 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 224326002255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326002256 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 224326002257 Chemotaxis phosphatase CheX; Region: CheX; cl15816 224326002258 Response regulator receiver domain; Region: Response_reg; pfam00072 224326002259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 224326002260 active site 224326002261 phosphorylation site [posttranslational modification] 224326002262 intermolecular recognition site; other site 224326002263 dimerization interface [polypeptide binding]; other site 224326002264 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 224326002265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 224326002266 motif II; other site 224326002267 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 224326002268 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 224326002269 Walker A/P-loop; other site 224326002270 ATP binding site [chemical binding]; other site 224326002271 Q-loop/lid; other site 224326002272 ABC transporter signature motif; other site 224326002273 Walker B; other site 224326002274 D-loop; other site 224326002275 H-loop/switch region; other site 224326002276 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002277 Walker A/P-loop; other site 224326002278 ATP binding site [chemical binding]; other site 224326002279 Q-loop/lid; other site 224326002280 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 224326002281 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 224326002282 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 224326002283 TM-ABC transporter signature motif; other site 224326002284 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 224326002285 TM-ABC transporter signature motif; other site 224326002286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 224326002287 dimer interface [polypeptide binding]; other site 224326002288 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 224326002289 putative CheW interface [polypeptide binding]; other site 224326002290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 224326002291 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 224326002292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 224326002293 dimer interface [polypeptide binding]; other site 224326002294 putative CheW interface [polypeptide binding]; other site 224326002295 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 224326002296 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 224326002297 Ligand Binding Site [chemical binding]; other site 224326002298 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 224326002299 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 224326002300 dimer interface [polypeptide binding]; other site 224326002301 active site 224326002302 isopentenyl-diphosphate delta-isomerase, type 2; Region: IPP_isom_2; TIGR02151 224326002303 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 224326002304 homotetramer interface [polypeptide binding]; other site 224326002305 FMN binding site [chemical binding]; other site 224326002306 homodimer contacts [polypeptide binding]; other site 224326002307 putative active site [active] 224326002308 putative substrate binding site [chemical binding]; other site 224326002309 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 224326002310 homodimer interface [polypeptide binding]; other site 224326002311 catalytic residues [active] 224326002312 NAD binding site [chemical binding]; other site 224326002313 substrate binding pocket [chemical binding]; other site 224326002314 flexible flap; other site 224326002315 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 224326002316 Phosphomevalonate kinase [Lipid metabolism]; Region: ERG8; COG3890 224326002317 mevalonate kinase; Region: mevalon_kin; TIGR00549 224326002318 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 224326002319 Ferritin-like domain; Region: Ferritin; pfam00210 224326002320 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 224326002321 dimerization interface [polypeptide binding]; other site 224326002322 DPS ferroxidase diiron center [ion binding]; other site 224326002323 ion pore; other site 224326002324 elongation factor G; Reviewed; Region: PRK13351 224326002325 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 224326002326 G1 box; other site 224326002327 putative GEF interaction site [polypeptide binding]; other site 224326002328 GTP/Mg2+ binding site [chemical binding]; other site 224326002329 Switch I region; other site 224326002330 G2 box; other site 224326002331 G3 box; other site 224326002332 Switch II region; other site 224326002333 G4 box; other site 224326002334 G5 box; other site 224326002335 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 224326002336 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 224326002337 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 224326002338 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 224326002339 signal recognition particle protein; Provisional; Region: PRK10867 224326002340 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 224326002341 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 224326002342 P loop; other site 224326002343 GTP binding site [chemical binding]; other site 224326002344 Signal peptide binding domain; Region: SRP_SPB; pfam02978 224326002345 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 224326002346 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 224326002347 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 224326002348 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14594 224326002349 RimM N-terminal domain; Region: RimM; pfam01782 224326002350 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 224326002351 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 224326002352 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 224326002353 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224326002354 active site 224326002355 nucleotide binding site [chemical binding]; other site 224326002356 HIGH motif; other site 224326002357 KMSKS motif; other site 224326002358 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 224326002359 Phosphopantetheine attachment site; Region: PP-binding; cl09936 224326002360 ribonuclease III; Reviewed; Region: rnc; PRK00102 224326002361 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 224326002362 dimerization interface [polypeptide binding]; other site 224326002363 active site 224326002364 metal binding site [ion binding]; metal-binding site 224326002365 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 224326002366 dsRNA binding site [nucleotide binding]; other site 224326002367 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 224326002368 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 224326002369 active site 224326002370 NTP binding site [chemical binding]; other site 224326002371 metal binding triad [ion binding]; metal-binding site 224326002372 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 224326002373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 224326002374 YceG-like family; Region: YceG; pfam02618 224326002375 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 224326002376 dimerization interface [polypeptide binding]; other site 224326002377 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 224326002378 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 224326002379 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 224326002380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 224326002381 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 224326002382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 224326002383 DNA binding residues [nucleotide binding] 224326002384 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 224326002385 Putative zinc ribbon domain; Region: DUF164; pfam02591 224326002386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 224326002387 binding surface 224326002388 TPR repeat; Region: TPR_11; pfam13414 224326002389 TPR motif; other site 224326002390 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 224326002391 Cell division protein FtsA; Region: FtsA; cl11496 224326002392 rod shape-determining protein MreC; Region: mreC; TIGR00219 224326002393 rod shape-determining protein MreC; Region: MreC; pfam04085 224326002394 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 224326002395 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 224326002396 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 224326002397 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 224326002398 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 224326002399 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 224326002400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326002401 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 224326002402 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 224326002403 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 224326002404 P-loop; other site 224326002405 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 224326002406 active site 224326002407 ADP/pyrophosphate binding site [chemical binding]; other site 224326002408 dimerization interface [polypeptide binding]; other site 224326002409 allosteric effector site; other site 224326002410 fructose-1,6-bisphosphate binding site; other site 224326002411 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 224326002412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 224326002413 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 224326002414 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 224326002415 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 224326002416 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 224326002417 active site 224326002418 dimer interface [polypeptide binding]; other site 224326002419 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 224326002420 dimer interface [polypeptide binding]; other site 224326002421 active site 224326002422 ParB-like nuclease domain; Region: ParBc; cl02129 224326002423 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 224326002424 Transglycosylase; Region: Transgly; cl07896 224326002425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 224326002426 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 224326002427 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 224326002428 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 224326002429 rare lipoprotein A; Region: rlpA; TIGR00413 224326002430 Sporulation related domain; Region: SPOR; cl10051 224326002431 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 224326002432 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 224326002433 FMN binding site [chemical binding]; other site 224326002434 active site 224326002435 catalytic residues [active] 224326002436 substrate binding site [chemical binding]; other site 224326002437 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 224326002438 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224326002439 active site 224326002440 HIGH motif; other site 224326002441 nucleotide binding site [chemical binding]; other site 224326002442 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 224326002443 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 224326002444 active site 224326002445 KMSKS motif; other site 224326002446 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 224326002447 tRNA binding surface [nucleotide binding]; other site 224326002448 anticodon binding site; other site 224326002449 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 224326002450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 224326002451 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 224326002452 oligomerisation interface [polypeptide binding]; other site 224326002453 mobile loop; other site 224326002454 roof hairpin; other site 224326002455 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 224326002456 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002457 Walker A/P-loop; other site 224326002458 ATP binding site [chemical binding]; other site 224326002459 Q-loop/lid; other site 224326002460 ABC transporter signature motif; other site 224326002461 Walker B; other site 224326002462 D-loop; other site 224326002463 H-loop/switch region; other site 224326002464 ABC transporter; Region: ABC_tran_2; pfam12848 224326002465 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 224326002466 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 224326002467 active site 224326002468 FOG: WD40-like repeat [Function unknown]; Region: COG1520 224326002469 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 224326002470 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 224326002471 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 224326002472 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 224326002473 minor groove reading motif; other site 224326002474 helix-hairpin-helix signature motif; other site 224326002475 substrate binding pocket [chemical binding]; other site 224326002476 active site 224326002477 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 224326002478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 224326002479 ABC-ATPase subunit interface; other site 224326002480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 224326002481 Septum formation initiator; Region: DivIC; cl11433 224326002482 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 224326002483 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 224326002484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002485 Walker A/P-loop; other site 224326002486 ATP binding site [chemical binding]; other site 224326002487 Q-loop/lid; other site 224326002488 ABC transporter signature motif; other site 224326002489 Walker B; other site 224326002490 D-loop; other site 224326002491 H-loop/switch region; other site 224326002492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 224326002493 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 224326002494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326002495 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 224326002496 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 224326002497 oligomer interface [polypeptide binding]; other site 224326002498 active site residues [active] 224326002499 Domain of unknown function (DUF368); Region: DUF368; cl00893 224326002500 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 224326002501 sensory histidine kinase AtoS; Provisional; Region: PRK11360 224326002502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 224326002503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 224326002504 ATP binding site [chemical binding]; other site 224326002505 G-X-G motif; other site 224326002506 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812 224326002507 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812 224326002508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002509 Colicin V production protein; Region: Colicin_V; cl00567 224326002510 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 224326002511 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 224326002512 homodimer interface [polypeptide binding]; other site 224326002513 active site 224326002514 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 224326002515 dimer interface [polypeptide binding]; other site 224326002516 pyridoxal binding site [chemical binding]; other site 224326002517 ATP binding site [chemical binding]; other site 224326002518 UGMP family protein; Validated; Region: PRK09604 224326002519 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 224326002520 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 224326002521 NodB motif; other site 224326002522 putative active site [active] 224326002523 putative catalytic site [active] 224326002524 Zn binding site [ion binding]; other site 224326002525 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 224326002526 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 224326002527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 224326002528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 224326002529 DNA binding residues [nucleotide binding] 224326002530 Rod binding protein; Region: Rod-binding; cl01626 224326002531 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 224326002532 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 224326002533 SAF-like; Region: SAF_2; pfam13144 224326002534 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 224326002535 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 224326002536 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 224326002537 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 224326002538 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 224326002539 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 224326002540 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 224326002541 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 224326002542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 224326002543 active site 224326002544 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 224326002545 Protein of unknown function (DUF464); Region: DUF464; cl01080 224326002546 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 224326002547 GTPase CgtA; Reviewed; Region: obgE; PRK12299 224326002548 GTP1/OBG; Region: GTP1_OBG; pfam01018 224326002549 Obg GTPase; Region: Obg; cd01898 224326002550 G1 box; other site 224326002551 GTP/Mg2+ binding site [chemical binding]; other site 224326002552 Switch I region; other site 224326002553 G2 box; other site 224326002554 G3 box; other site 224326002555 Switch II region; other site 224326002556 G4 box; other site 224326002557 G5 box; other site 224326002558 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 224326002559 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 224326002560 active site 224326002561 (T/H)XGH motif; other site 224326002562 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 224326002563 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 224326002564 Oligomerisation domain; Region: Oligomerisation; cl00519 224326002565 SpoVG; Region: SpoVG; cl00915 224326002566 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 224326002567 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 224326002568 5S rRNA interface [nucleotide binding]; other site 224326002569 CTC domain interface [polypeptide binding]; other site 224326002570 L16 interface [polypeptide binding]; other site 224326002571 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 224326002572 putative active site [active] 224326002573 catalytic residue [active] 224326002574 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 224326002575 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 224326002576 Ligand Binding Site [chemical binding]; other site 224326002577 FtsH Extracellular; Region: FtsH_ext; pfam06480 224326002578 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 224326002579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326002580 Walker A motif; other site 224326002581 ATP binding site [chemical binding]; other site 224326002582 Walker B motif; other site 224326002583 arginine finger; other site 224326002584 Peptidase family M41; Region: Peptidase_M41; pfam01434 224326002585 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 224326002586 thymidylate kinase; Region: DTMP_kinase; TIGR00041 224326002587 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 224326002588 TMP-binding site; other site 224326002589 ATP-binding site [chemical binding]; other site 224326002590 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 224326002591 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 224326002592 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 224326002593 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 224326002594 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 224326002595 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 224326002596 Surface antigen; Region: Bac_surface_Ag; cl03097 224326002597 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 224326002598 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 224326002599 MutS domain I; Region: MutS_I; pfam01624 224326002600 MutS domain II; Region: MutS_II; pfam05188 224326002601 MutS family domain IV; Region: MutS_IV; pfam05190 224326002602 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 224326002603 Walker A/P-loop; other site 224326002604 ATP binding site [chemical binding]; other site 224326002605 Q-loop/lid; other site 224326002606 ABC transporter signature motif; other site 224326002607 Walker B; other site 224326002608 D-loop; other site 224326002609 H-loop/switch region; other site 224326002610 comF family protein; Region: comF; TIGR00201 224326002611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 224326002612 active site 224326002613 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 224326002614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 224326002615 transcription termination factor NusA; Region: NusA; TIGR01953 224326002616 NusA N-terminal domain; Region: NusA_N; pfam08529 224326002617 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 224326002618 RNA binding site [nucleotide binding]; other site 224326002619 homodimer interface [polypeptide binding]; other site 224326002620 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 224326002621 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 224326002622 G-X-X-G motif; other site 224326002623 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 224326002624 translation initiation factor IF-2; Region: IF-2; TIGR00487 224326002625 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 224326002626 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 224326002627 G1 box; other site 224326002628 putative GEF interaction site [polypeptide binding]; other site 224326002629 GTP/Mg2+ binding site [chemical binding]; other site 224326002630 Switch I region; other site 224326002631 G2 box; other site 224326002632 G3 box; other site 224326002633 Switch II region; other site 224326002634 G4 box; other site 224326002635 G5 box; other site 224326002636 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 224326002637 Translation-initiation factor 2; Region: IF-2; pfam11987 224326002638 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 224326002639 Ribosome-binding factor A; Region: RBFA; cl00542 224326002640 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 224326002641 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 224326002642 RNA binding site [nucleotide binding]; other site 224326002643 active site 224326002644 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 224326002645 16S/18S rRNA binding site [nucleotide binding]; other site 224326002646 S13e-L30e interaction site [polypeptide binding]; other site 224326002647 25S rRNA binding site [nucleotide binding]; other site 224326002648 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 224326002649 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 224326002650 RNase E interface [polypeptide binding]; other site 224326002651 trimer interface [polypeptide binding]; other site 224326002652 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 224326002653 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 224326002654 RNase E interface [polypeptide binding]; other site 224326002655 trimer interface [polypeptide binding]; other site 224326002656 active site 224326002657 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 224326002658 putative nucleic acid binding region [nucleotide binding]; other site 224326002659 G-X-X-G motif; other site 224326002660 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 224326002661 RNA binding site [nucleotide binding]; other site 224326002662 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 224326002663 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 224326002664 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 224326002665 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 224326002666 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 224326002667 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 224326002668 integral membrane protein MviN; Region: mviN; TIGR01695 224326002669 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 224326002670 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic; Region: coaBC_dfp; TIGR00521 224326002671 Flavoprotein; Region: Flavoprotein; cl08021 224326002672 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 224326002673 Sodium:solute symporter family; Region: SSF; cl00456 224326002674 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 224326002675 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 224326002676 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224326002677 TIGR00255 family protein; Region: TIGR00255 224326002678 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 224326002679 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 224326002680 cytidylate kinase; Provisional; Region: PRK04182 224326002681 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 224326002682 CMP-binding site; other site 224326002683 The sites determining sugar specificity; other site 224326002684 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 224326002685 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002686 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 224326002687 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 224326002688 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 224326002689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 224326002690 ATP binding site [chemical binding]; other site 224326002691 putative Mg++ binding site [ion binding]; other site 224326002692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 224326002693 nucleotide binding region [chemical binding]; other site 224326002694 ATP-binding site [chemical binding]; other site 224326002695 Helicase associated domain (HA2); Region: HA2; cl04503 224326002696 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 224326002697 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 224326002698 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 224326002699 active site 224326002700 interdomain interaction site; other site 224326002701 putative metal-binding site [ion binding]; other site 224326002702 nucleotide binding site [chemical binding]; other site 224326002703 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 224326002704 domain I; other site 224326002705 phosphate binding site [ion binding]; other site 224326002706 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 224326002707 domain III; other site 224326002708 nucleotide binding site [chemical binding]; other site 224326002709 DNA binding groove [nucleotide binding] 224326002710 catalytic site [active] 224326002711 domain II; other site 224326002712 domain IV; other site 224326002713 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 224326002714 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 224326002715 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 224326002716 active site 224326002717 metal binding site [ion binding]; metal-binding site 224326002718 DNA binding site [nucleotide binding] 224326002719 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 224326002720 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002721 Walker A/P-loop; other site 224326002722 ATP binding site [chemical binding]; other site 224326002723 Q-loop/lid; other site 224326002724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002725 ABC transporter signature motif; other site 224326002726 Walker B; other site 224326002727 D-loop; other site 224326002728 H-loop/switch region; other site 224326002729 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 224326002730 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 224326002731 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 224326002732 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 224326002733 HIGH motif; other site 224326002734 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 224326002735 active site 224326002736 KMSKS motif; other site 224326002737 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 224326002738 tRNA binding surface [nucleotide binding]; other site 224326002739 anticodon binding site; other site 224326002740 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 224326002741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326002742 Walker A motif; other site 224326002743 ATP binding site [chemical binding]; other site 224326002744 Walker B motif; other site 224326002745 arginine finger; other site 224326002746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224326002747 Walker A motif; other site 224326002748 ATP binding site [chemical binding]; other site 224326002749 Walker B motif; other site 224326002750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 224326002751 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 224326002752 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 224326002753 active site 224326002754 substrate binding site [chemical binding]; other site 224326002755 metal binding site [ion binding]; metal-binding site 224326002756 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 224326002757 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 224326002758 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 224326002759 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 224326002760 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 224326002761 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 224326002762 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 224326002763 Amidinotransferase; Region: Amidinotransf; cl12043 224326002764 ornithine carbamoyltransferase; Provisional; Region: PRK04284 224326002765 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 224326002766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 224326002767 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 224326002768 Uncharacterized conserved protein [Function unknown]; Region: COG4748 224326002769 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 224326002770 Uncharacterized conserved protein [Function unknown]; Region: COG3586 224326002771 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002772 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002773 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002774 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002775 P-loop; other site 224326002776 Magnesium ion binding site [ion binding]; other site 224326002777 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002778 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002779 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002780 P-loop; other site 224326002781 Magnesium ion binding site [ion binding]; other site 224326002782 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002783 Magnesium ion binding site [ion binding]; other site 224326002784 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002785 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002786 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 224326002787 catalytic triad [active] 224326002788 conserved cis-peptide bond; other site 224326002789 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002790 Erp protein C-terminus; Region: Erp_C; pfam06780 224326002791 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002792 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002793 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002794 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002795 P-loop; other site 224326002796 Magnesium ion binding site [ion binding]; other site 224326002797 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002798 Magnesium ion binding site [ion binding]; other site 224326002799 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002800 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002801 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 224326002802 Predicted helicase [General function prediction only]; Region: COG4889 224326002803 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002804 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002805 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002806 P-loop; other site 224326002807 Magnesium ion binding site [ion binding]; other site 224326002808 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002809 Magnesium ion binding site [ion binding]; other site 224326002810 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 224326002812 Phage terminase large subunit; Region: Terminase_3; cl12054 224326002813 Right handed beta helix region; Region: Beta_helix; pfam13229 224326002814 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 224326002815 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326002816 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002817 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002818 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002819 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 224326002820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002821 Walker A motif; other site 224326002822 ATP binding site [chemical binding]; other site 224326002823 Walker B motif; other site 224326002824 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002825 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 224326002826 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002827 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002828 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002829 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002830 P-loop; other site 224326002831 Magnesium ion binding site [ion binding]; other site 224326002832 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002833 Magnesium ion binding site [ion binding]; other site 224326002834 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002835 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002836 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 224326002837 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 224326002838 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 224326002839 Probable transposase; Region: OrfB_IS605; pfam01385 224326002840 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 224326002841 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 224326002842 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002843 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002844 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002845 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002846 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002847 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002848 P-loop; other site 224326002849 Magnesium ion binding site [ion binding]; other site 224326002850 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002851 Magnesium ion binding site [ion binding]; other site 224326002852 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 224326002854 putative substrate translocation pore; other site 224326002855 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002856 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002857 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 224326002858 Protein of unknown function (DUF541); Region: SIMPL; cl01077 224326002859 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002860 adenine deaminase; Region: ade; TIGR01178 224326002861 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 224326002862 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 224326002863 active site 224326002864 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 224326002865 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002866 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002867 Magnesium ion binding site [ion binding]; other site 224326002868 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002869 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002870 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002871 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 224326002872 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 224326002873 Borrelia outer surface protein D (OspD); Region: OspD; pfam03207 224326002874 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002875 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002876 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002877 P-loop; other site 224326002878 Magnesium ion binding site [ion binding]; other site 224326002879 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002880 Magnesium ion binding site [ion binding]; other site 224326002881 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002882 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002883 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 224326002884 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 224326002885 Walker A/P-loop; other site 224326002886 ATP binding site [chemical binding]; other site 224326002887 Q-loop/lid; other site 224326002888 ABC transporter signature motif; other site 224326002889 Walker B; other site 224326002890 D-loop; other site 224326002891 H-loop/switch region; other site 224326002892 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 224326002893 FtsX-like permease family; Region: FtsX; cl15850 224326002894 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 224326002895 DUF276; Region: DUF276; pfam03434 224326002896 Protein of unknown function (DUF735); Region: DUF735; pfam05246 224326002897 Protein of unknown function (DUF685); Region: DUF685; pfam05085 224326002898 Protein of unknown function (DUF685); Region: DUF685; pfam05085 224326002899 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 224326002900 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 224326002901 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002902 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002903 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002904 P-loop; other site 224326002905 Magnesium ion binding site [ion binding]; other site 224326002906 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002907 Magnesium ion binding site [ion binding]; other site 224326002908 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002909 Protein of unknown function, DUF261; Region: DUF261; pfam03196 224326002910 Decorin binding protein; Region: Decorin_bind; pfam02352 224326002911 Decorin binding protein; Region: Decorin_bind; pfam02352 224326002912 Protein of unknown function, DUF603; Region: DUF603; pfam04645 224326002913 Phage terminase large subunit; Region: Terminase_3; cl12054 224326002914 Terminase-like family; Region: Terminase_6; pfam03237 224326002915 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 224326002916 peptide binding site [polypeptide binding]; other site 224326002917 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 224326002918 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 224326002919 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 224326002920 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 224326002921 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 224326002922 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 224326002923 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 224326002924 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 224326002925 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 224326002926 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 224326002927 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 224326002928 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002929 Herpes virus major outer envelope glycoprotein (BLLF1); Region: Herpes_BLLF1; pfam05109 224326002930 stage II sporulation protein E; Region: spore_II_E; TIGR02865 224326002931 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 224326002932 OMS28 porin; Region: OMS28_porin; pfam03532 224326002933 Thymidylate synthase complementing protein; Region: Thy1; cl03630 224326002934 Acylphosphatase; Region: Acylphosphatase; cl00551 224326002935 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 224326002936 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 224326002937 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 224326002938 methionine cluster; other site 224326002939 active site 224326002940 phosphorylation site [posttranslational modification] 224326002941 metal binding site [ion binding]; metal-binding site 224326002942 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 224326002943 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 224326002944 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002945 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 224326002946 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 224326002947 P-loop; other site 224326002948 Magnesium ion binding site [ion binding]; other site 224326002949 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 224326002950 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002951 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 224326002952 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 224326002953 peptide binding site [polypeptide binding]; other site 224326002954 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 224326002955 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 224326002956 active site 224326002957 GMP synthase; Reviewed; Region: guaA; PRK00074 224326002958 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 224326002959 AMP/PPi binding site [chemical binding]; other site 224326002960 candidate oxyanion hole; other site 224326002961 catalytic triad [active] 224326002962 potential glutamine specificity residues [chemical binding]; other site 224326002963 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 224326002964 ATP Binding subdomain [chemical binding]; other site 224326002965 Ligand Binding sites [chemical binding]; other site 224326002966 Dimerization subdomain; other site 224326002967 Lipoprotein; Region: Lipoprotein_6; pfam01441 224326002968 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 224326002969 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 224326002970 Domain of unknown function (DUF955); Region: DUF955; cl01076 224326002971 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 224326002972 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 224326002973 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 224326002974 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 224326002975 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 224326002976 active site turn [active] 224326002977 phosphorylation site [posttranslational modification] 224326002978 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 224326002979 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 224326002980 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 224326002981 ERF superfamily; Region: ERF; pfam04404 224326002982 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 224326002983 Borrelia burgdorferi REV protein; Region: Borrelia_REV; pfam03978 224326002984 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 224326002985 active site 224326002986 catalytic residues [active] 224326002987 DNA binding site [nucleotide binding] 224326002988 Int/Topo IB signature motif; other site 224326002989 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 224326002990 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112