-- dump date 20111121_010647 -- class Genbank::misc_feature -- table misc_feature_note -- id note 445985000001 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985000002 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985000003 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985000004 DUF276; Region: DUF276; pfam03434 445985000005 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985000006 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985000007 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985000008 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985000009 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 445985000010 Mlp lipoprotein family; Region: Mlp; pfam03304 445985000011 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985000012 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985000013 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985000014 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985000015 P-loop; other site 445985000016 Magnesium ion binding site [ion binding]; other site 445985000017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985000018 Magnesium ion binding site [ion binding]; other site 445985000019 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985000020 transferase, transferring glycosyl groups; Region: PLN02939 445985000021 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985000022 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 445985000023 DNA binding site [nucleotide binding] 445985000024 Int/Topo IB signature motif; other site 445985000025 active site 445985000026 catalytic residues [active] 445985000027 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985000028 Phage terminase large subunit; Region: Terminase_3; cl12054 445985000029 Terminase-like family; Region: Terminase_6; pfam03237 445985000030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 445985000031 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 445985000032 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985000033 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000034 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000035 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000036 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985000037 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985000038 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985000039 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985000040 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985000041 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985000042 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985000043 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985000044 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985000045 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985000046 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985000047 DUF276; Region: DUF276; pfam03434 445985000048 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985000049 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985000050 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985000051 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985000052 ERF superfamily; Region: ERF; pfam04404 445985000053 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985000054 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985000055 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985000056 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985000057 P-loop; other site 445985000058 Magnesium ion binding site [ion binding]; other site 445985000059 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985000060 Magnesium ion binding site [ion binding]; other site 445985000061 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985000062 phosphodiesterase; Provisional; Region: PRK12704 445985000063 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 445985000064 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985000065 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985000066 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 445985000067 DNA binding site [nucleotide binding] 445985000068 Int/Topo IB signature motif; other site 445985000069 active site 445985000070 catalytic residues [active] 445985000071 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 445985000072 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985000073 Terminase-like family; Region: Terminase_6; pfam03237 445985000074 Phage terminase large subunit; Region: Terminase_3; cl12054 445985000075 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985000076 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000077 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000078 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000079 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985000080 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985000081 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985000082 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985000083 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985000084 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985000085 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985000086 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985000087 DUF276; Region: DUF276; pfam03434 445985000088 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 445985000089 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985000090 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985000091 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional; Region: PLN03229 445985000092 Mlp lipoprotein family; Region: Mlp; pfam03304 445985000093 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985000094 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985000095 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985000096 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985000097 P-loop; other site 445985000098 Magnesium ion binding site [ion binding]; other site 445985000099 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985000100 Magnesium ion binding site [ion binding]; other site 445985000101 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985000102 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 445985000103 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985000104 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985000105 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 445985000106 DNA binding site [nucleotide binding] 445985000107 Int/Topo IB signature motif; other site 445985000108 active site 445985000109 catalytic residues [active] 445985000110 Borrelia outer surface protein E; Region: OspE; pfam02471 445985000111 Erp protein C-terminus; Region: Erp_C; pfam06780 445985000112 Protein of unknown function (DUF643); Region: DUF643; pfam04867 445985000113 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985000114 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 445985000115 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 445985000116 methionine cluster; other site 445985000117 active site 445985000118 phosphorylation site [posttranslational modification] 445985000119 metal binding site [ion binding]; metal-binding site 445985000120 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 445985000121 active site 445985000122 P-loop; other site 445985000123 phosphorylation site [posttranslational modification] 445985000124 Uncharacterized conserved protein [Function unknown]; Region: COG3589 445985000125 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 445985000126 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985000127 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985000128 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985000129 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985000130 P-loop; other site 445985000131 Magnesium ion binding site [ion binding]; other site 445985000132 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985000133 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 445985000134 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985000135 peptide binding site [polypeptide binding]; other site 445985000136 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 445985000137 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 445985000138 active site 445985000139 GMP synthase; Reviewed; Region: guaA; PRK00074 445985000140 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 445985000141 AMP/PPi binding site [chemical binding]; other site 445985000142 candidate oxyanion hole; other site 445985000143 catalytic triad [active] 445985000144 potential glutamine specificity residues [chemical binding]; other site 445985000145 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 445985000146 ATP Binding subdomain [chemical binding]; other site 445985000147 Ligand Binding sites [chemical binding]; other site 445985000148 Dimerization subdomain; other site 445985000149 Lipoprotein; Region: Lipoprotein_6; pfam01441 445985000150 Sulfate transporter family; Region: Sulfate_transp; cl00967 445985000151 Sulfate transporter family; Region: Sulfate_transp; cl00967 445985000152 Domain of unknown function (DUF955); Region: DUF955; cl01076 445985000153 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445985000154 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445985000155 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 445985000156 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 445985000157 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 445985000158 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 445985000159 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 445985000160 active site 445985000161 substrate binding site [chemical binding]; other site 445985000162 metal binding site [ion binding]; metal-binding site 445985000163 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 445985000164 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 445985000165 active site 445985000166 HIGH motif; other site 445985000167 dimer interface [polypeptide binding]; other site 445985000168 KMSKS motif; other site 445985000169 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 445985000170 Domain of unknown function DUF20; Region: UPF0118; cl00465 445985000171 TIGR00159 family protein; Region: TIGR00159 445985000172 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 445985000173 YbbR-like protein; Region: YbbR; pfam07949 445985000174 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 445985000175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 445985000176 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 445985000177 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 445985000178 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 445985000179 dimerization interface 3.5A [polypeptide binding]; other site 445985000180 active site 445985000181 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 445985000182 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 445985000183 primosomal protein N'; Region: priA; TIGR00595 445985000184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985000185 ATP binding site [chemical binding]; other site 445985000186 putative Mg++ binding site [ion binding]; other site 445985000187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 445985000188 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 445985000189 ATP-binding site [chemical binding]; other site 445985000190 Sugar specificity; other site 445985000191 Pyrimidine base specificity; other site 445985000192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 445985000193 active site residue [active] 445985000194 Uncharacterized conserved protein [Function unknown]; Region: COG1284 445985000195 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 445985000196 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 445985000197 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 445985000198 active site 445985000199 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent...; Region: Pyrophosphate_PFK; cd00765 445985000200 active site 445985000201 pyrophosphate binding site [ion binding]; other site 445985000202 dimerization interface [polypeptide binding]; other site 445985000203 fructose-6-phosphate binding site; other site 445985000204 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 445985000205 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 445985000206 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 445985000207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985000208 Walker A motif; other site 445985000209 ATP binding site [chemical binding]; other site 445985000210 Walker B motif; other site 445985000211 arginine finger; other site 445985000212 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 445985000213 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK13901 445985000214 RuvA N terminal domain; Region: RuvA_N; pfam01330 445985000215 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 445985000216 Domain of unknown function DUF28; Region: DUF28; cl00361 445985000217 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 445985000218 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 445985000219 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 445985000220 homodimer interface [polypeptide binding]; other site 445985000221 NADP binding site [chemical binding]; other site 445985000222 substrate binding site [chemical binding]; other site 445985000223 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 445985000224 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 445985000225 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 445985000226 Catalytic site [active] 445985000227 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 445985000228 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 445985000229 PEGA domain; Region: PEGA; pfam08308 445985000230 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 445985000231 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 445985000232 SmpB-tmRNA interface; other site 445985000233 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 445985000234 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 445985000235 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cl00148 445985000236 CAP-like domain; other site 445985000237 Active site [active] 445985000238 primary dimer interface [polypeptide binding]; other site 445985000239 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 445985000240 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 445985000241 anchoring element; other site 445985000242 dimer interface [polypeptide binding]; other site 445985000243 ATP binding site [chemical binding]; other site 445985000244 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both...; Region: TOPRIM_TopoIIA_like; cd01030 445985000245 active site 445985000246 putative metal-binding site [ion binding]; other site 445985000247 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 445985000248 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 445985000249 putative acyl-acceptor binding pocket; other site 445985000250 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 445985000251 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 445985000252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985000253 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 445985000254 PhoU domain; Region: PhoU; pfam01895 445985000255 PhoU domain; Region: PhoU; pfam01895 445985000256 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 445985000257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985000258 Walker A/P-loop; other site 445985000259 ATP binding site [chemical binding]; other site 445985000260 RecF/RecN/SMC N terminal domain; Region: SMC_N; pfam02463 445985000261 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 445985000262 ABC transporter signature motif; other site 445985000263 Walker B; other site 445985000264 D-loop; other site 445985000265 H-loop/switch region; other site 445985000266 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 445985000267 RNA/DNA hybrid binding site [nucleotide binding]; other site 445985000268 active site 445985000269 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 445985000270 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 445985000271 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 445985000272 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 445985000273 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 445985000274 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 445985000275 substrate binding site [chemical binding]; other site 445985000276 dimer interface [polypeptide binding]; other site 445985000277 catalytic triad [active] 445985000278 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 445985000279 substrate binding site [chemical binding]; other site 445985000280 hinge regions; other site 445985000281 ADP binding site [chemical binding]; other site 445985000282 catalytic site [active] 445985000283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445985000284 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 445985000285 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 445985000286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000287 binding surface 445985000288 TPR motif; other site 445985000289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000290 binding surface 445985000291 TPR motif; other site 445985000292 FOG: CBS domain [General function prediction only]; Region: COG0517 445985000293 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 445985000294 Transporter associated domain; Region: CorC_HlyC; pfam03471 445985000295 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 445985000296 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 445985000297 catalytic residues [active] 445985000298 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 445985000299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 445985000300 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 445985000301 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 445985000302 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 445985000303 methionyl-tRNA formyltransferase; Region: fmt; TIGR00460 445985000304 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 445985000305 putative active site [active] 445985000306 substrate binding site [chemical binding]; other site 445985000307 putative cosubstrate binding site; other site 445985000308 catalytic site [active] 445985000309 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 445985000310 substrate binding site [chemical binding]; other site 445985000311 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 445985000312 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 445985000313 active site 445985000314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 445985000315 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 445985000316 active site 445985000317 motif I; other site 445985000318 motif II; other site 445985000319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 445985000320 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 445985000321 Divergent PAP2 family; Region: DUF212; cl00855 445985000322 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 445985000323 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 445985000324 RF-1 domain; Region: RF-1; cl02875 445985000325 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 445985000326 RF-1 domain; Region: RF-1; cl02875 445985000327 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 445985000328 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 445985000329 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 445985000330 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 445985000331 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 445985000332 Walker A/P-loop; other site 445985000333 ATP binding site [chemical binding]; other site 445985000334 Q-loop/lid; other site 445985000335 ABC transporter signature motif; other site 445985000336 Walker B; other site 445985000337 D-loop; other site 445985000338 H-loop/switch region; other site 445985000339 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 445985000340 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 445985000341 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 445985000342 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 445985000343 catalytic residue [active] 445985000344 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 445985000345 trimerization site [polypeptide binding]; other site 445985000346 active site 445985000347 Mg chelatase-related protein; Region: TIGR00368 445985000348 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985000349 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 445985000350 tetramer (dimer of dimers) interface [polypeptide binding]; other site 445985000351 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 445985000352 NAD binding site [chemical binding]; other site 445985000353 dimer interface [polypeptide binding]; other site 445985000354 substrate binding site [chemical binding]; other site 445985000355 GTP-binding protein LepA; Provisional; Region: PRK05433 445985000356 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 445985000357 Switch I region; other site 445985000358 G2 box; other site 445985000359 putative GEF interaction site [polypeptide binding]; other site 445985000360 G3 box; other site 445985000361 Switch II region; other site 445985000362 GTP/Mg2+ binding site [chemical binding]; other site 445985000363 G4 box; other site 445985000364 G5 box; other site 445985000365 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 445985000366 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 445985000367 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 445985000368 V-type ATP synthase subunit K; Validated; Region: PRK06649 445985000369 ATP synthase subunit D; Region: ATP-synt_D; cl00613 445985000370 V-type ATP synthase subunit B; Provisional; Region: PRK02118 445985000371 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 445985000372 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the...; Region: V_A-ATPase_B; cd01135 445985000373 Walker A motif homologous position; other site 445985000374 Walker B motif; other site 445985000375 V-type ATP synthase subunit A; Provisional; Region: PRK04192 445985000376 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 445985000377 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 445985000378 Walker A motif/ATP binding site; other site 445985000379 Walker B motif; other site 445985000380 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 445985000381 MutS2 family protein; Region: mutS2; TIGR01069 445985000382 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 445985000383 Walker A/P-loop; other site 445985000384 ATP binding site [chemical binding]; other site 445985000385 Q-loop/lid; other site 445985000386 ABC transporter signature motif; other site 445985000387 Walker B; other site 445985000388 D-loop; other site 445985000389 H-loop/switch region; other site 445985000390 Smr domain; Region: Smr; cl02619 445985000391 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 445985000392 ribosome small subunit-dependent GTPase A; Region: TIGR00157 445985000393 GTPase/OB domain interface [polypeptide binding]; other site 445985000394 GTPase/Zn-binding domain interface [polypeptide binding]; other site 445985000395 GTP/Mg2+ binding site [chemical binding]; other site 445985000396 G4 box; other site 445985000397 G5 box; other site 445985000398 G1 box; other site 445985000399 Switch I region; other site 445985000400 G2 box; other site 445985000401 G3 box; other site 445985000402 Switch II region; other site 445985000403 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 445985000404 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 445985000405 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 445985000406 putative dimer interface [polypeptide binding]; other site 445985000407 putative anticodon binding site; other site 445985000408 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 445985000409 homodimer interface [polypeptide binding]; other site 445985000410 motif 1; other site 445985000411 motif 2; other site 445985000412 active site 445985000413 motif 3; other site 445985000414 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 445985000415 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 445985000416 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 445985000417 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 445985000418 protein binding site [polypeptide binding]; other site 445985000419 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 445985000420 protein binding site [polypeptide binding]; other site 445985000421 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 445985000422 active site 445985000423 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 445985000424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000425 binding surface 445985000426 TPR motif; other site 445985000427 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 445985000428 putative RNA binding site [nucleotide binding]; other site 445985000429 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 445985000430 SurA N-terminal domain; Region: SurA_N; pfam09312 445985000431 PPIC-type PPIASE domain; Region: Rotamase; cl08278 445985000432 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 445985000433 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 445985000434 dimer interface [polypeptide binding]; other site 445985000435 active site 445985000436 replicative DNA helicase; Region: DnaB; TIGR00665 445985000437 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 445985000438 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 445985000439 Walker A motif; other site 445985000440 ATP binding site [chemical binding]; other site 445985000441 Walker B motif; other site 445985000442 DNA binding loops [nucleotide binding] 445985000443 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 445985000444 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 445985000445 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 445985000446 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 445985000447 dimer interface [polypeptide binding]; other site 445985000448 ssDNA binding site [nucleotide binding]; other site 445985000449 tetramer (dimer of dimers) interface [polypeptide binding]; other site 445985000450 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 445985000451 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 445985000452 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 445985000453 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 445985000454 active site turn [active] 445985000455 phosphorylation site [posttranslational modification] 445985000456 Haemolysin-III related; Region: HlyIII; cl03831 445985000457 RIP metalloprotease RseP; Region: TIGR00054 445985000458 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 445985000459 active site 445985000460 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 445985000461 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 445985000462 protein binding site [polypeptide binding]; other site 445985000463 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 445985000464 putative substrate binding region [chemical binding]; other site 445985000465 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 445985000466 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 445985000467 catalytic residue [active] 445985000468 putative FPP diphosphate binding site; other site 445985000469 putative FPP binding hydrophobic cleft; other site 445985000470 dimer interface [polypeptide binding]; other site 445985000471 putative IPP diphosphate binding site; other site 445985000472 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 445985000473 hinge region; other site 445985000474 translation elongation factor Ts; Region: tsf; TIGR00116 445985000475 Elongation factor TS; Region: EF_TS; pfam00889 445985000476 Elongation factor TS; Region: EF_TS; pfam00889 445985000477 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 445985000478 rRNA interaction site [nucleotide binding]; other site 445985000479 S8 interaction site; other site 445985000480 putative laminin-1 binding site; other site 445985000481 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 445985000482 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 445985000483 RNA binding site [nucleotide binding]; other site 445985000484 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 445985000485 RNA binding site [nucleotide binding]; other site 445985000486 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 445985000487 RNA binding site [nucleotide binding]; other site 445985000488 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cd00164 445985000489 RNA binding site [nucleotide binding]; other site 445985000490 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 445985000491 cytidylate kinase; Region: cmk; TIGR00017 445985000492 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 445985000493 CMP-binding site; other site 445985000494 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 445985000495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 445985000496 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 445985000497 active site 445985000498 recombinase A; Provisional; Region: recA; PRK09354 445985000499 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 445985000500 hexamer interface [polypeptide binding]; other site 445985000501 Walker A motif; other site 445985000502 ATP binding site [chemical binding]; other site 445985000503 Walker B motif; other site 445985000504 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 445985000505 domain; Region: GreA_GreB_N; pfam03449 445985000506 C-term; Region: GreA_GreB; pfam01272 445985000507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000508 binding surface 445985000509 TPR motif; other site 445985000510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000511 TPR motif; other site 445985000512 binding surface 445985000513 histidyl-tRNA synthetase; Region: hisS; TIGR00442 445985000514 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 445985000515 dimer interface [polypeptide binding]; other site 445985000516 motif 1; other site 445985000517 active site 445985000518 motif 2; other site 445985000519 motif 3; other site 445985000520 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 445985000521 anticodon binding site; other site 445985000522 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 445985000523 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 445985000524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 445985000525 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 445985000526 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 445985000527 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 445985000528 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 445985000529 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 445985000530 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 445985000531 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 445985000532 Outer membrane efflux protein; Region: OEP; pfam02321 445985000533 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 445985000534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 445985000535 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 445985000536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 445985000537 dimer interface [polypeptide binding]; other site 445985000538 conserved gate region; other site 445985000539 putative PBP binding loops; other site 445985000540 ABC-ATPase subunit interface; other site 445985000541 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 445985000542 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 445985000543 Walker A/P-loop; other site 445985000544 ATP binding site [chemical binding]; other site 445985000545 Q-loop/lid; other site 445985000546 ABC transporter signature motif; other site 445985000547 Walker B; other site 445985000548 D-loop; other site 445985000549 H-loop/switch region; other site 445985000550 flagellin; Provisional; Region: PRK12803 445985000551 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 445985000552 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 445985000553 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 445985000554 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 445985000555 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 445985000556 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 445985000557 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 445985000558 active site 445985000559 dimer interface [polypeptide binding]; other site 445985000560 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 445985000561 active site 445985000562 trimer interface [polypeptide binding]; other site 445985000563 allosteric site; other site 445985000564 active site lid [active] 445985000565 hexamer (dimer of trimers) interface [polypeptide binding]; other site 445985000566 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 445985000567 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 445985000568 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 445985000569 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 445985000570 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 445985000571 SEC-C motif; Region: SEC-C; cl12132 445985000572 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 445985000573 alanine racemase; Region: alr; TIGR00492 445985000574 active site 445985000575 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 445985000576 dimer interface [polypeptide binding]; other site 445985000577 substrate binding site [chemical binding]; other site 445985000578 catalytic residues [active] 445985000579 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 445985000580 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 445985000581 Uncharacterized conserved protein [Function unknown]; Region: COG1306 445985000582 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 445985000583 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445985000584 ligand binding site [chemical binding]; other site 445985000585 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 445985000586 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 445985000587 rRNA binding site [nucleotide binding]; other site 445985000588 predicted 30S ribosome binding site; other site 445985000589 Bacterial SH3 domain; Region: SH3_3; cl02551 445985000590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000591 binding surface 445985000592 TPR motif; other site 445985000593 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 445985000594 metal ion-dependent adhesion site (MIDAS); other site 445985000595 Aerotolerance regulator N-terminal; Region: BatA; cl06567 445985000596 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 445985000597 metal ion-dependent adhesion site (MIDAS); other site 445985000598 Protein of unknown function DUF58; Region: DUF58; pfam01882 445985000599 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 445985000600 MoxR-like ATPases [General function prediction only]; Region: COG0714 445985000601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985000602 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 445985000603 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 445985000604 glucose-inhibited division protein A; Region: gidA; TIGR00136 445985000605 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 445985000606 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 445985000607 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 445985000608 GTP/Mg2+ binding site [chemical binding]; other site 445985000609 G4 box; other site 445985000610 G5 box; other site 445985000611 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 445985000612 G1 box; other site 445985000613 G1 box; other site 445985000614 GTP/Mg2+ binding site [chemical binding]; other site 445985000615 Switch I region; other site 445985000616 Switch I region; other site 445985000617 G2 box; other site 445985000618 G2 box; other site 445985000619 Switch II region; other site 445985000620 G3 box; other site 445985000621 G3 box; other site 445985000622 Switch II region; other site 445985000623 G4 box; other site 445985000624 G5 box; other site 445985000625 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 445985000626 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 445985000627 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 445985000628 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 445985000629 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 445985000630 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 445985000631 FliW protein; Region: FliW; cl00740 445985000632 Global regulator protein family; Region: CsrA; cl00670 445985000633 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 445985000634 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 445985000635 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 445985000636 23S rRNA binding site [nucleotide binding]; other site 445985000637 L21 binding site [polypeptide binding]; other site 445985000638 L13 binding site [polypeptide binding]; other site 445985000639 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 445985000640 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 445985000641 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 445985000642 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 445985000643 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 445985000644 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 445985000645 active site 445985000646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000647 binding surface 445985000648 TPR motif; other site 445985000649 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 445985000650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000651 binding surface 445985000652 TPR motif; other site 445985000653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000654 binding surface 445985000655 TPR motif; other site 445985000656 peptide chain release factor 1; Validated; Region: prfA; PRK00591 445985000657 RF-1 domain; Region: RF-1; cl02875 445985000658 RF-1 domain; Region: RF-1; cl02875 445985000659 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 445985000660 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 445985000661 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 445985000662 synthetase active site [active] 445985000663 NTP binding site [chemical binding]; other site 445985000664 metal binding site [ion binding]; metal-binding site 445985000665 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 445985000666 D-alanyl-alanine synthetase A; Provisional; Region: PRK14570 445985000667 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 445985000668 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 445985000669 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 445985000670 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 445985000671 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445985000672 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445985000673 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 445985000674 Domain of unknown function DUF21; Region: DUF21; pfam01595 445985000675 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 445985000676 Transporter associated domain; Region: CorC_HlyC; pfam03471 445985000677 HflK protein; Region: hflK; TIGR01933 445985000678 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 445985000679 FtsH protease regulator HflC; Provisional; Region: PRK11029 445985000680 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 445985000681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985000682 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 445985000683 active site 445985000684 tetramer interface [polypeptide binding]; other site 445985000685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 445985000686 binding surface 445985000687 TPR motif; other site 445985000688 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 445985000689 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 445985000690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000691 TPR motif; other site 445985000692 binding surface 445985000693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000694 binding surface 445985000695 TPR motif; other site 445985000696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000697 binding surface 445985000698 TPR motif; other site 445985000699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000700 TPR motif; other site 445985000701 binding surface 445985000702 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 445985000703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 445985000704 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 445985000705 ATP binding site [chemical binding]; other site 445985000706 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 445985000707 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 445985000708 translation elongation factor P; Region: efp; TIGR00038 445985000709 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 445985000710 RNA binding site [nucleotide binding]; other site 445985000711 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 445985000712 RNA binding site [nucleotide binding]; other site 445985000713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 445985000714 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 445985000715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 445985000716 dimer interface [polypeptide binding]; other site 445985000717 conserved gate region; other site 445985000718 putative PBP binding loops; other site 445985000719 ABC-ATPase subunit interface; other site 445985000720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 445985000721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 445985000722 dimer interface [polypeptide binding]; other site 445985000723 conserved gate region; other site 445985000724 putative PBP binding loops; other site 445985000725 ABC-ATPase subunit interface; other site 445985000726 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14273 445985000727 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 445985000728 Walker A/P-loop; other site 445985000729 ATP binding site [chemical binding]; other site 445985000730 Q-loop/lid; other site 445985000731 ABC transporter signature motif; other site 445985000732 Walker B; other site 445985000733 D-loop; other site 445985000734 H-loop/switch region; other site 445985000735 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 445985000736 ZIP Zinc transporter; Region: Zip; pfam02535 445985000737 alanyl-tRNA synthetase; Provisional; Region: PRK01584 445985000738 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 445985000739 motif 1; other site 445985000740 active site 445985000741 motif 2; other site 445985000742 motif 3; other site 445985000743 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 445985000744 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 445985000745 FliG C-terminal domain; Region: FliG_C; pfam01706 445985000746 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 445985000747 putative active site [active] 445985000748 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 445985000749 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 445985000750 FMN binding site [chemical binding]; other site 445985000751 active site 445985000752 catalytic residues [active] 445985000753 substrate binding site [chemical binding]; other site 445985000754 seryl-tRNA synthetase; Region: serS; TIGR00414 445985000755 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 445985000756 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 445985000757 dimer interface [polypeptide binding]; other site 445985000758 active site 445985000759 motif 1; other site 445985000760 motif 2; other site 445985000761 motif 3; other site 445985000762 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 445985000763 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 445985000764 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 445985000765 Peptidase M16C associated; Region: M16C_assoc; pfam08367 445985000766 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 445985000767 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 445985000768 transcription termination factor Rho; Region: rho; TIGR00767 445985000769 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 445985000770 RNA binding site [nucleotide binding]; other site 445985000771 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 445985000772 multimer interface [polypeptide binding]; other site 445985000773 Walker A motif; other site 445985000774 ATP binding site [chemical binding]; other site 445985000775 Walker B motif; other site 445985000776 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 445985000777 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 445985000778 IHF dimer interface [polypeptide binding]; other site 445985000779 IHF - DNA interface [nucleotide binding]; other site 445985000780 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 445985000781 GTP-binding protein YchF; Reviewed; Region: PRK09601 445985000782 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 445985000783 G1 box; other site 445985000784 GTP/Mg2+ binding site [chemical binding]; other site 445985000785 Switch I region; other site 445985000786 G2 box; other site 445985000787 Switch II region; other site 445985000788 G3 box; other site 445985000789 G4 box; other site 445985000790 G5 box; other site 445985000791 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 445985000792 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 445985000793 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 445985000794 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 445985000795 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 445985000796 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 445985000797 Substrate-binding site [chemical binding]; other site 445985000798 Substrate specificity [chemical binding]; other site 445985000799 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 445985000800 amphipathic channel; other site 445985000801 Asn-Pro-Ala signature motifs; other site 445985000802 glycerol kinase; Provisional; Region: glpK; PRK00047 445985000803 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 445985000804 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 445985000805 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 445985000806 Protein of unknown function (DUF327); Region: DUF327; cl00753 445985000807 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 445985000808 Peptidase family M23; Region: Peptidase_M23; pfam01551 445985000809 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 445985000810 active site 445985000811 dimerization interface [polypeptide binding]; other site 445985000812 oligoendopeptidase F; Region: pepF; TIGR00181 445985000813 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 445985000814 active site 445985000815 Zn binding site [ion binding]; other site 445985000816 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 445985000817 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 445985000818 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 445985000819 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 445985000820 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 445985000821 HIGH motif; other site 445985000822 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445985000823 active site 445985000824 KMSKS motif; other site 445985000825 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 445985000826 tRNA binding surface [nucleotide binding]; other site 445985000827 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 445985000828 Found in ATP-dependent protease La (LON); Region: LON; cl01056 445985000829 ATP-dependent protease La; Region: lon; TIGR00763 445985000830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985000831 Walker A motif; other site 445985000832 ATP binding site [chemical binding]; other site 445985000833 Walker B motif; other site 445985000834 arginine finger; other site 445985000835 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 445985000836 DHH family; Region: DHH; pfam01368 445985000837 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 445985000838 DHHA1 domain; Region: DHHA1; pfam02272 445985000839 Peptidase family M23; Region: Peptidase_M23; pfam01551 445985000840 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 445985000841 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 445985000842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985000843 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 445985000844 Bacitracin resistance protein BacA; Region: BacA; cl00858 445985000845 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 445985000846 N-acetyl-D-glucosamine binding site [chemical binding]; other site 445985000847 catalytic residue [active] 445985000848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000849 binding surface 445985000850 TPR motif; other site 445985000851 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 445985000852 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 445985000853 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 445985000854 putative peptidoglycan binding site; other site 445985000855 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 445985000856 putative peptidoglycan binding site; other site 445985000857 Peptidase family M23; Region: Peptidase_M23; pfam01551 445985000858 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 445985000859 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 445985000860 Catalytic site [active] 445985000861 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 445985000862 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 445985000863 ATP binding site [chemical binding]; other site 445985000864 profilin binding site; other site 445985000865 Uncharacterized conserved protein [Function unknown]; Region: COG1315 445985000866 Integral peroxisomal membrane peroxin; Region: Pex24p; pfam06398 445985000867 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 445985000868 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 445985000869 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 445985000870 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 445985000871 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 445985000872 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 445985000873 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 445985000874 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 445985000875 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 445985000876 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 445985000877 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 445985000878 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 445985000879 FliP family; Region: FliP; cl00593 445985000880 flagellar biosynthesis protein FliZ; Provisional; Region: PRK13414 445985000881 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 445985000882 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 445985000883 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 445985000884 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 445985000885 flagellar motor protein MotB; Validated; Region: motB; PRK06667 445985000886 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445985000887 ligand binding site [chemical binding]; other site 445985000888 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 445985000889 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 445985000890 Flagellar protein (FlbD); Region: FlbD; cl00683 445985000891 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 445985000892 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 445985000893 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 445985000894 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 445985000895 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 445985000896 Flagellar hook capping protein; Region: FlgD; cl04347 445985000897 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 445985000898 ATPase FliI/YscN family; Region: fliI_yscN; TIGR01026 445985000899 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 445985000900 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 445985000901 Walker A motif/ATP binding site; other site 445985000902 Walker B motif; other site 445985000903 flagellar assembly protein H; Validated; Region: fliH; PRK06669 445985000904 Flagellar assembly protein FliH; Region: FliH; pfam02108 445985000905 flagellar motor switch protein FliG; Region: fliG; TIGR00207 445985000906 FliG C-terminal domain; Region: FliG_C; pfam01706 445985000907 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 445985000908 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 445985000909 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 445985000910 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 445985000911 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 445985000912 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 445985000913 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 445985000914 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622 445985000915 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 445985000916 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 445985000917 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985000918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985000919 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985000920 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 445985000921 active site 445985000922 HslU subunit interaction site [polypeptide binding]; other site 445985000923 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 445985000924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 445985000925 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 445985000926 cell division protein FtsZ; Validated; Region: PRK09330 445985000927 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 445985000928 nucleotide binding site [chemical binding]; other site 445985000929 SulA interaction site; other site 445985000930 cell division protein FtsA; Region: ftsA; TIGR01174 445985000931 Cell division protein FtsA; Region: FtsA; cl11496 445985000932 Cell division protein FtsA; Region: FtsA; cl11496 445985000933 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 445985000934 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 445985000935 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 445985000936 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 445985000937 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 445985000938 Mg++ binding site [ion binding]; other site 445985000939 putative catalytic motif [active] 445985000940 putative substrate binding site [chemical binding]; other site 445985000941 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 445985000942 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445985000943 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445985000944 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 445985000945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985000946 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 445985000947 ATP-NAD kinase; Region: NAD_kinase; pfam01513 445985000948 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 445985000949 putative CheA interaction surface; other site 445985000950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985000951 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 445985000952 substrate binding pocket [chemical binding]; other site 445985000953 chain length determination region; other site 445985000954 substrate-Mg2+ binding site; other site 445985000955 catalytic residues [active] 445985000956 aspartate-rich region 1; other site 445985000957 active site lid residues [active] 445985000958 aspartate-rich region 2; other site 445985000959 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 445985000960 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 445985000961 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 445985000962 TM-ABC transporter signature motif; other site 445985000963 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 445985000964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985000965 Walker A/P-loop; other site 445985000966 ATP binding site [chemical binding]; other site 445985000967 Q-loop/lid; other site 445985000968 ABC transporter signature motif; other site 445985000969 Walker B; other site 445985000970 D-loop; other site 445985000971 H-loop/switch region; other site 445985000972 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985000973 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 445985000974 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 445985000975 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 445985000976 metal ion-dependent adhesion site (MIDAS); other site 445985000977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985000978 binding surface 445985000979 TPR motif; other site 445985000980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 445985000981 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 445985000982 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985000983 peptide binding site [polypeptide binding]; other site 445985000984 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 445985000985 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985000986 peptide binding site [polypeptide binding]; other site 445985000987 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 445985000988 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985000989 peptide binding site [polypeptide binding]; other site 445985000990 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 445985000991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 445985000992 dimer interface [polypeptide binding]; other site 445985000993 conserved gate region; other site 445985000994 putative PBP binding loops; other site 445985000995 ABC-ATPase subunit interface; other site 445985000996 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 445985000997 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 445985000998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 445985000999 dimer interface [polypeptide binding]; other site 445985001000 conserved gate region; other site 445985001001 putative PBP binding loops; other site 445985001002 ABC-ATPase subunit interface; other site 445985001003 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 445985001004 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 445985001005 Walker A/P-loop; other site 445985001006 ATP binding site [chemical binding]; other site 445985001007 Q-loop/lid; other site 445985001008 ABC transporter signature motif; other site 445985001009 Walker B; other site 445985001010 D-loop; other site 445985001011 H-loop/switch region; other site 445985001012 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 445985001013 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cd02688 445985001014 enolase; Provisional; Region: eno; PRK00077 445985001015 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 445985001016 dimer interface [polypeptide binding]; other site 445985001017 metal binding site [ion binding]; metal-binding site 445985001018 substrate binding pocket [chemical binding]; other site 445985001019 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 445985001020 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 445985001021 23S rRNA interface [nucleotide binding]; other site 445985001022 L3 interface [polypeptide binding]; other site 445985001023 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 445985001024 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 445985001025 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 445985001026 GatB domain; Region: GatB_Yqey; cl11497 445985001027 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 445985001028 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 445985001029 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 445985001030 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 445985001031 UvrD/REP helicase; Region: UvrD-helicase; cl14126 445985001032 UvrD/REP helicase; Region: UvrD-helicase; cl14126 445985001033 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 445985001034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 445985001035 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 445985001036 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 445985001037 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 445985001038 Domain of unknown function (DUF814); Region: DUF814; pfam05670 445985001039 pyruvate kinase; Region: pyruv_kin; TIGR01064 445985001040 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 445985001041 domain interfaces; other site 445985001042 active site 445985001043 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 445985001044 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 445985001045 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 445985001046 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 445985001047 C-terminal peptidase (prc); Region: prc; TIGR00225 445985001048 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 445985001049 protein binding site [polypeptide binding]; other site 445985001050 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 445985001051 Catalytic dyad [active] 445985001052 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 445985001053 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 445985001054 P-loop; other site 445985001055 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 445985001056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 445985001057 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 445985001058 active site 445985001059 dimer interfaces [polypeptide binding]; other site 445985001060 catalytic residues [active] 445985001061 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 445985001062 oligomer interface [polypeptide binding]; other site 445985001063 putative active site [active] 445985001064 metal binding site [ion binding]; metal-binding site 445985001065 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 445985001066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445985001067 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 445985001068 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 445985001069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985001070 Walker A motif; other site 445985001071 ATP binding site [chemical binding]; other site 445985001072 Walker B motif; other site 445985001073 arginine finger; other site 445985001074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985001075 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 445985001076 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 445985001077 active site 445985001078 HIGH motif; other site 445985001079 dimer interface [polypeptide binding]; other site 445985001080 KMSKS motif; other site 445985001081 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 445985001082 glycyl-tRNA synthetase; Provisional; Region: PRK04173 445985001083 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 445985001084 dimer interface [polypeptide binding]; other site 445985001085 motif 1; other site 445985001086 active site 445985001087 motif 2; other site 445985001088 motif 3; other site 445985001089 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 445985001090 anticodon binding site; other site 445985001091 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 445985001092 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 445985001093 active site 445985001094 HIGH motif; other site 445985001095 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 445985001096 active site 445985001097 KMSKS motif; other site 445985001098 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 445985001099 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 445985001100 S-adenosylmethionine synthetase; Region: metK; TIGR01034 445985001101 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 445985001102 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 445985001103 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 445985001104 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 445985001105 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 445985001106 HIT family signature motif; other site 445985001107 catalytic residue [active] 445985001108 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 445985001109 MgtE intracellular N domain; Region: MgtE_N; cl15244 445985001110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 445985001111 Divalent cation transporter; Region: MgtE; cl00786 445985001112 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 445985001113 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 445985001114 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001115 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 445985001116 ligand binding site [chemical binding]; other site 445985001117 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001118 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 445985001119 ligand binding site [chemical binding]; other site 445985001120 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001121 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 445985001122 ligand binding site [chemical binding]; other site 445985001123 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001124 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 445985001125 ligand binding site [chemical binding]; other site 445985001126 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 445985001127 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 445985001128 S17 interaction site [polypeptide binding]; other site 445985001129 S8 interaction site; other site 445985001130 16S rRNA interaction site [nucleotide binding]; other site 445985001131 streptomycin interaction site [chemical binding]; other site 445985001132 23S rRNA interaction site [nucleotide binding]; other site 445985001133 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 445985001134 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 445985001135 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 445985001136 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 445985001137 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 445985001138 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 445985001139 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 445985001140 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 445985001141 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 445985001142 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 445985001143 cleft; other site 445985001144 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 445985001145 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 445985001146 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 445985001147 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 445985001148 DNA binding site [nucleotide binding] 445985001149 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 445985001150 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 445985001151 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 445985001152 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 445985001153 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 445985001154 RPB10 interaction site [polypeptide binding]; other site 445985001155 RPB1 interaction site [polypeptide binding]; other site 445985001156 RPB11 interaction site [polypeptide binding]; other site 445985001157 RPB3 interaction site [polypeptide binding]; other site 445985001158 RPB12 interaction site [polypeptide binding]; other site 445985001159 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 445985001160 core dimer interface [polypeptide binding]; other site 445985001161 peripheral dimer interface [polypeptide binding]; other site 445985001162 L10 interface [polypeptide binding]; other site 445985001163 L11 interface [polypeptide binding]; other site 445985001164 putative EF-Tu interaction site [polypeptide binding]; other site 445985001165 putative EF-G interaction site [polypeptide binding]; other site 445985001166 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 445985001167 23S rRNA interface [nucleotide binding]; other site 445985001168 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 445985001169 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 445985001170 mRNA/rRNA interface [nucleotide binding]; other site 445985001171 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 445985001172 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 445985001173 23S rRNA interface [nucleotide binding]; other site 445985001174 L7/L12 interface [polypeptide binding]; other site 445985001175 putative thiostrepton binding site; other site 445985001176 L25 interface [polypeptide binding]; other site 445985001177 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 445985001178 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 445985001179 putative homodimer interface [polypeptide binding]; other site 445985001180 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 445985001181 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445985001182 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445985001183 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 445985001184 prolyl-tRNA synthetase; Provisional; Region: PRK08661 445985001185 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 445985001186 dimer interface [polypeptide binding]; other site 445985001187 motif 1; other site 445985001188 active site 445985001189 motif 2; other site 445985001190 motif 3; other site 445985001191 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity...; Region: ProRS_anticodon_zinc; cd00862 445985001192 anticodon binding site; other site 445985001193 zinc-binding site [ion binding]; other site 445985001194 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 445985001195 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 445985001196 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 445985001197 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 445985001198 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 445985001199 active site 445985001200 phosphorylation site [posttranslational modification] 445985001201 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 445985001202 P-loop; other site 445985001203 active site 445985001204 phosphorylation site [posttranslational modification] 445985001205 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 445985001206 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 445985001207 active site 445985001208 substrate binding site [chemical binding]; other site 445985001209 Mg2+ binding site [ion binding]; other site 445985001210 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 445985001211 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 445985001212 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 445985001213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985001214 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 445985001215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 445985001216 active site 445985001217 phosphorylation site [posttranslational modification] 445985001218 intermolecular recognition site; other site 445985001219 CheB methylesterase; Region: CheB_methylest; pfam01339 445985001220 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 445985001221 TraB family; Region: TraB; cl12050 445985001222 adenylate kinase; Provisional; Region: PRK14526 445985001223 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 445985001224 AMP-binding site [chemical binding]; other site 445985001225 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 445985001226 Response regulator receiver domain; Region: Response_reg; pfam00072 445985001227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 445985001228 active site 445985001229 phosphorylation site [posttranslational modification] 445985001230 intermolecular recognition site; other site 445985001231 dimerization interface [polypeptide binding]; other site 445985001232 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 445985001233 metal binding site [ion binding]; metal-binding site 445985001234 active site 445985001235 I-site; other site 445985001236 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 445985001237 substrate binding pocket [chemical binding]; other site 445985001238 membrane-bound complex binding site; other site 445985001239 hinge residues; other site 445985001240 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 445985001241 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 445985001242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 445985001243 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 445985001244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985001245 ATP binding site [chemical binding]; other site 445985001246 Mg2+ binding site [ion binding]; other site 445985001247 G-X-G motif; other site 445985001248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 445985001249 active site 445985001250 phosphorylation site [posttranslational modification] 445985001251 intermolecular recognition site; other site 445985001252 dimerization interface [polypeptide binding]; other site 445985001253 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 445985001254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 445985001255 active site 445985001256 motif I; other site 445985001257 motif II; other site 445985001258 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 445985001259 active site 445985001260 DNA binding site [nucleotide binding] 445985001261 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 445985001262 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 445985001263 Domain of unknown function (DUF1893); Region: DUF1893; pfam08973 445985001264 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 445985001265 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 445985001266 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985001267 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985001268 P-loop; other site 445985001269 Magnesium ion binding site [ion binding]; other site 445985001270 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985001271 Magnesium ion binding site [ion binding]; other site 445985001272 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 445985001273 ParB-like partition proteins; Region: parB_part; TIGR00180 445985001274 ParB-like nuclease domain; Region: ParBc; cl02129 445985001275 DNA gyrase, A subunit; Region: gyrA; TIGR01063 445985001276 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 445985001277 CAP-like domain; other site 445985001278 Active site [active] 445985001279 primary dimer interface [polypeptide binding]; other site 445985001280 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445985001281 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445985001282 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445985001283 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445985001284 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 445985001285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985001286 ATP binding site [chemical binding]; other site 445985001287 Mg2+ binding site [ion binding]; other site 445985001288 G-X-G motif; other site 445985001289 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 445985001290 anchoring element; other site 445985001291 dimer interface [polypeptide binding]; other site 445985001292 ATP binding site [chemical binding]; other site 445985001293 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 445985001294 active site 445985001295 putative metal-binding site [ion binding]; other site 445985001296 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 445985001297 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 445985001298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985001299 Walker A motif; other site 445985001300 ATP binding site [chemical binding]; other site 445985001301 Walker B motif; other site 445985001302 arginine finger; other site 445985001303 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 445985001304 DnaA box-binding interface [nucleotide binding]; other site 445985001305 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 445985001306 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 445985001307 putative DNA binding surface [nucleotide binding]; other site 445985001308 dimer interface [polypeptide binding]; other site 445985001309 beta-clamp/clamp loader binding surface; other site 445985001310 beta-clamp/translesion DNA polymerase binding surface; other site 445985001311 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 445985001312 Ribonuclease P; Region: Ribonuclease_P; cl00457 445985001313 membrane protein insertase; Provisional; Region: PRK01318 445985001314 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 445985001315 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 445985001316 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 445985001317 G-X-X-G motif; other site 445985001318 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 445985001319 RxxxH motif; other site 445985001320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 445985001321 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 445985001322 putative NAD(P) binding site [chemical binding]; other site 445985001323 active site 445985001324 putative substrate binding site [chemical binding]; other site 445985001325 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 445985001326 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 445985001327 active site 445985001328 intersubunit interface [polypeptide binding]; other site 445985001329 zinc binding site [ion binding]; other site 445985001330 Na+ binding site [ion binding]; other site 445985001331 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 445985001332 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 445985001333 dimer interface [polypeptide binding]; other site 445985001334 anticodon binding site; other site 445985001335 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 445985001336 homodimer interface [polypeptide binding]; other site 445985001337 motif 1; other site 445985001338 active site 445985001339 motif 2; other site 445985001340 GAD domain; Region: GAD; pfam02938 445985001341 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 445985001342 motif 3; other site 445985001343 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 445985001344 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 445985001345 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 445985001346 active site 445985001347 phosphorylation site [posttranslational modification] 445985001348 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 445985001349 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cl00250 445985001350 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 445985001351 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 445985001352 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 445985001353 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 445985001354 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 445985001355 Chromate transporter; Region: Chromate_transp; pfam02417 445985001356 Chromate transporter; Region: Chromate_transp; pfam02417 445985001357 Mechanosensitive ion channel; Region: MS_channel; pfam00924 445985001358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 445985001359 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 445985001360 putative ADP-binding pocket [chemical binding]; other site 445985001361 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 445985001362 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 445985001363 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14670 445985001364 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 445985001365 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 445985001366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985001367 binding surface 445985001368 TPR motif; other site 445985001369 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647 445985001370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985001371 Walker A motif; other site 445985001372 ATP binding site [chemical binding]; other site 445985001373 Walker B motif; other site 445985001374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985001375 arginine finger; other site 445985001376 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 445985001377 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 445985001378 active site 445985001379 multimer interface [polypeptide binding]; other site 445985001380 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 445985001381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 445985001382 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 445985001383 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 445985001384 Walker A/P-loop; other site 445985001385 ATP binding site [chemical binding]; other site 445985001386 Q-loop/lid; other site 445985001387 ABC transporter signature motif; other site 445985001388 Walker B; other site 445985001389 D-loop; other site 445985001390 H-loop/switch region; other site 445985001391 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 445985001392 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 445985001393 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 445985001394 Uncharacterized conserved protein [Function unknown]; Region: COG0327 445985001395 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 445985001396 lipoprotein signal peptidase; Provisional; Region: PRK14787 445985001397 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 445985001398 active site 445985001399 metal binding site [ion binding]; metal-binding site 445985001400 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 445985001401 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 445985001402 hinge; other site 445985001403 active site 445985001404 putative efflux protein, MATE family; Region: matE; TIGR00797 445985001405 MatE; Region: MatE; pfam01554 445985001406 MatE; Region: MatE; pfam01554 445985001407 elongation factor Tu; Reviewed; Region: PRK00049 445985001408 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 445985001409 G1 box; other site 445985001410 GEF interaction site [polypeptide binding]; other site 445985001411 GTP/Mg2+ binding site [chemical binding]; other site 445985001412 Switch I region; other site 445985001413 G2 box; other site 445985001414 G3 box; other site 445985001415 Switch II region; other site 445985001416 G4 box; other site 445985001417 G5 box; other site 445985001418 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 445985001419 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 445985001420 Antibiotic Binding Site [chemical binding]; other site 445985001421 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 445985001422 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 445985001423 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 445985001424 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 445985001425 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 445985001426 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 445985001427 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 445985001428 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 445985001429 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 445985001430 putative translocon binding site; other site 445985001431 protein-rRNA interface [nucleotide binding]; other site 445985001432 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 445985001433 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 445985001434 G-X-X-G motif; other site 445985001435 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 445985001436 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 445985001437 23S rRNA interface [nucleotide binding]; other site 445985001438 5S rRNA interface [nucleotide binding]; other site 445985001439 putative antibiotic binding site [chemical binding]; other site 445985001440 L25 interface [polypeptide binding]; other site 445985001441 L27 interface [polypeptide binding]; other site 445985001442 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 445985001443 23S rRNA interface [nucleotide binding]; other site 445985001444 putative translocon interaction site; other site 445985001445 signal recognition particle (SRP54) interaction site; other site 445985001446 L23 interface [polypeptide binding]; other site 445985001447 trigger factor interaction site; other site 445985001448 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 445985001449 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 445985001450 KOW motif; Region: KOW; cl00354 445985001451 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 445985001452 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 445985001453 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 445985001454 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 445985001455 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 445985001456 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 445985001457 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 445985001458 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 445985001459 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 445985001460 5S rRNA interface [nucleotide binding]; other site 445985001461 23S rRNA interface [nucleotide binding]; other site 445985001462 L5 interface [polypeptide binding]; other site 445985001463 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 445985001464 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 445985001465 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 445985001466 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30_like; cl00203 445985001467 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 445985001468 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 445985001469 SecY translocase; Region: SecY; pfam00344 445985001470 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 445985001471 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 445985001472 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 445985001473 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 445985001474 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 445985001475 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 445985001476 alphaNTD - beta interaction site [polypeptide binding]; other site 445985001477 alphaNTD homodimer interface [polypeptide binding]; other site 445985001478 alphaNTD - beta' interaction site [polypeptide binding]; other site 445985001479 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 445985001480 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 445985001481 phosphodiesterase; Provisional; Region: PRK12704 445985001482 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 445985001483 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 445985001484 Zn2+ binding site [ion binding]; other site 445985001485 Mg2+ binding site [ion binding]; other site 445985001486 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 445985001487 putative active site [active] 445985001488 metal binding site [ion binding]; metal-binding site 445985001489 homodimer binding site [polypeptide binding]; other site 445985001490 hemolysin TlyA family protein; Region: tly; TIGR00478 445985001491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985001492 Spore germination protein [General function prediction only]; Region: COG5401 445985001493 Sporulation and spore germination; Region: Germane; pfam10646 445985001494 GTP-binding protein Der; Reviewed; Region: PRK00093 445985001495 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 445985001496 G1 box; other site 445985001497 GTP/Mg2+ binding site [chemical binding]; other site 445985001498 Switch I region; other site 445985001499 G2 box; other site 445985001500 Switch II region; other site 445985001501 G3 box; other site 445985001502 G4 box; other site 445985001503 G5 box; other site 445985001504 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 445985001505 G1 box; other site 445985001506 GTP/Mg2+ binding site [chemical binding]; other site 445985001507 Switch I region; other site 445985001508 G2 box; other site 445985001509 G3 box; other site 445985001510 Switch II region; other site 445985001511 G4 box; other site 445985001512 G5 box; other site 445985001513 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 445985001514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 445985001515 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 445985001516 V-type ATP synthase subunit I; Validated; Region: PRK05771 445985001517 chromosome segregation protein; Provisional; Region: PRK03918 445985001518 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 445985001519 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 445985001520 dimer interface [polypeptide binding]; other site 445985001521 motif 1; other site 445985001522 active site 445985001523 motif 2; other site 445985001524 motif 3; other site 445985001525 phenylalanyl-tRNA synthetase, beta subunit; Region: pheT_arch; TIGR00471 445985001526 B3/4 domain; Region: B3_4; cl11458 445985001527 tRNA synthetase B5 domain; Region: B5; cl08394 445985001528 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 445985001529 motif 1; other site 445985001530 dimer interface [polypeptide binding]; other site 445985001531 active site 445985001532 motif 2; other site 445985001533 motif 3; other site 445985001534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 445985001535 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 445985001536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 445985001537 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 445985001538 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 445985001539 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 445985001540 chaperone protein DnaJ; Provisional; Region: PRK14285 445985001541 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 445985001542 HSP70 interaction site [polypeptide binding]; other site 445985001543 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 445985001544 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 445985001545 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 445985001546 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 445985001547 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 445985001548 dimer interface [polypeptide binding]; other site 445985001549 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 445985001550 NAD synthetase; Provisional; Region: PRK13981 445985001551 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 445985001552 active site 445985001553 catalytic triad [active] 445985001554 dimer interface [polypeptide binding]; other site 445985001555 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 445985001556 homodimer interface [polypeptide binding]; other site 445985001557 NAD binding pocket [chemical binding]; other site 445985001558 ATP binding pocket [chemical binding]; other site 445985001559 Mg binding site [ion binding]; other site 445985001560 active-site loop [active] 445985001561 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 445985001562 active site 445985001563 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 445985001564 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 445985001565 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 445985001566 active site 445985001567 catalytic tetrad [active] 445985001568 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 445985001569 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 445985001570 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 445985001571 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 445985001572 active site 445985001573 phosphate binding site A [ion binding]; other site 445985001574 putative catalytic site [active] 445985001575 DNA binding site [nucleotide binding] 445985001576 metal binding site A [ion binding]; metal-binding site 445985001577 putative AP binding site [nucleotide binding]; other site 445985001578 putative metal binding site B [ion binding]; other site 445985001579 phosphate binding site B [ion binding]; other site 445985001580 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 445985001581 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 445985001582 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 445985001583 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 445985001584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985001585 binding surface 445985001586 TPR motif; other site 445985001587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 445985001588 binding surface 445985001589 TPR motif; other site 445985001590 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 445985001591 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 445985001592 translation elongation factor EF-G; Region: EF-G; TIGR00484 445985001593 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 445985001594 G1 box; other site 445985001595 putative GEF interaction site [polypeptide binding]; other site 445985001596 GTP/Mg2+ binding site [chemical binding]; other site 445985001597 Switch I region; other site 445985001598 G2 box; other site 445985001599 G3 box; other site 445985001600 Switch II region; other site 445985001601 G4 box; other site 445985001602 G5 box; other site 445985001603 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 445985001604 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 445985001605 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 445985001606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 445985001607 binding surface 445985001608 TPR motif; other site 445985001609 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 445985001610 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 445985001611 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 445985001612 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 445985001613 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 445985001614 cell division protein FtsN; Region: ftsN; TIGR02223 445985001615 Sporulation related domain; Region: SPOR; cl10051 445985001616 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 445985001617 CoA-binding site [chemical binding]; other site 445985001618 ATP-binding [chemical binding]; other site 445985001619 DNA polymerase I; Region: pola; TIGR00593 445985001620 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 445985001621 active site 445985001622 metal binding site 1 [ion binding]; metal-binding site 445985001623 putative 5' ssDNA interaction site; other site 445985001624 metal binding site 3; metal-binding site 445985001625 metal binding site 2 [ion binding]; metal-binding site 445985001626 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 445985001627 putative DNA binding site [nucleotide binding]; other site 445985001628 putative metal binding site [ion binding]; other site 445985001629 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 445985001630 active site 445985001631 catalytic site [active] 445985001632 substrate binding site [chemical binding]; other site 445985001633 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 445985001634 active site 445985001635 DNA binding site [nucleotide binding] 445985001636 catalytic site [active] 445985001637 Flagellar protein FliS; Region: FliS; cl00654 445985001638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 445985001639 Response regulator receiver domain; Region: Response_reg; pfam00072 445985001640 active site 445985001641 phosphorylation site [posttranslational modification] 445985001642 intermolecular recognition site; other site 445985001643 dimerization interface [polypeptide binding]; other site 445985001644 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350 445985001645 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 445985001646 nucleotide binding pocket [chemical binding]; other site 445985001647 K-X-D-G motif; other site 445985001648 catalytic site [active] 445985001649 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 445985001650 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 445985001651 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cl00038 445985001652 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 445985001653 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 445985001654 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 445985001655 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 445985001656 dimerization domain swap beta strand [polypeptide binding]; other site 445985001657 regulatory protein interface [polypeptide binding]; other site 445985001658 active site 445985001659 regulatory phosphorylation site [posttranslational modification]; other site 445985001660 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 445985001661 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 445985001662 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 445985001663 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 445985001664 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 445985001665 HPr interaction site; other site 445985001666 glycerol kinase (GK) interaction site [polypeptide binding]; other site 445985001667 active site 445985001668 phosphorylation site [posttranslational modification] 445985001669 heat shock protein 90; Provisional; Region: PRK05218 445985001670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 445985001671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445985001672 6-phosphogluconate dehydrogenase, decarboxylating; Region: gnd; TIGR00873 445985001673 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 445985001674 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 445985001675 putative CheA interaction surface; other site 445985001676 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 445985001677 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 445985001678 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 445985001679 putative binding surface; other site 445985001680 active site 445985001681 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 445985001682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985001683 ATP binding site [chemical binding]; other site 445985001684 Mg2+ binding site [ion binding]; other site 445985001685 G-X-G motif; other site 445985001686 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 445985001687 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 445985001688 CheB methylesterase; Region: CheB_methylest; pfam01339 445985001689 chromosome segregation protein; Provisional; Region: PRK01156 445985001690 Response regulator receiver domain; Region: Response_reg; pfam00072 445985001691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 445985001692 active site 445985001693 phosphorylation site [posttranslational modification] 445985001694 intermolecular recognition site; other site 445985001695 dimerization interface [polypeptide binding]; other site 445985001696 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 445985001697 nucleotide binding site [chemical binding]; other site 445985001698 homodimeric interface [polypeptide binding]; other site 445985001699 uridine monophosphate binding site [chemical binding]; other site 445985001700 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 445985001701 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 445985001702 active site 445985001703 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 445985001704 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 445985001705 Walker A/P-loop; other site 445985001706 ATP binding site [chemical binding]; other site 445985001707 Q-loop/lid; other site 445985001708 ABC transporter signature motif; other site 445985001709 Walker B; other site 445985001710 D-loop; other site 445985001711 H-loop/switch region; other site 445985001712 CTP synthase; Region: PyrG; TIGR00337 445985001713 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 445985001714 Catalytic site [active] 445985001715 Active site [active] 445985001716 UTP binding site [chemical binding]; other site 445985001717 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 445985001718 active site 445985001719 putative oxyanion hole; other site 445985001720 catalytic triad [active] 445985001721 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 445985001722 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 445985001723 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 445985001724 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 445985001725 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 445985001726 generic binding surface I; other site 445985001727 generic binding surface II; other site 445985001728 YGGT family; Region: YGGT; cl00508 445985001729 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 445985001730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985001731 ATP binding site [chemical binding]; other site 445985001732 putative Mg++ binding site [ion binding]; other site 445985001733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985001734 nucleotide binding region [chemical binding]; other site 445985001735 ATP-binding site [chemical binding]; other site 445985001736 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 445985001737 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 445985001738 putative efflux protein, MATE family; Region: matE; TIGR00797 445985001739 MatE; Region: MatE; pfam01554 445985001740 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 445985001741 MatE; Region: MatE; pfam01554 445985001742 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 445985001743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445985001744 NAD(P) binding site [chemical binding]; other site 445985001745 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445985001746 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445985001747 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 445985001748 FemAB family; Region: FemAB; cl11444 445985001749 FemAB family; Region: FemAB; cl11444 445985001750 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 445985001751 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 445985001752 active site 445985001753 HIGH motif; other site 445985001754 KMSKS motif; other site 445985001755 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 445985001756 tRNA binding surface [nucleotide binding]; other site 445985001757 anticodon binding site; other site 445985001758 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-; Region: tRNA_bindingDomain; cd02153 445985001759 putative tRNA-binding site [nucleotide binding]; other site 445985001760 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 445985001761 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 445985001762 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 445985001763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985001764 Competence protein; Region: Competence; cl00471 445985001765 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 445985001766 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 445985001767 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 445985001768 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 445985001769 arginyl-tRNA synthetase; Region: argS; TIGR00456 445985001770 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 445985001771 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 445985001772 active site 445985001773 HIGH motif; other site 445985001774 KMSK motif region; other site 445985001775 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 445985001776 tRNA binding surface [nucleotide binding]; other site 445985001777 anticodon binding site; other site 445985001778 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 445985001779 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 445985001780 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14650 445985001781 FAD binding domain; Region: FAD_binding_4; pfam01565 445985001782 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 445985001783 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14534 445985001784 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445985001785 active site 445985001786 HIGH motif; other site 445985001787 nucleotide binding site [chemical binding]; other site 445985001788 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 445985001789 KMSKS motif; other site 445985001790 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 445985001791 tRNA binding surface [nucleotide binding]; other site 445985001792 anticodon binding site; other site 445985001793 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 445985001794 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 445985001795 dimer interface [polypeptide binding]; other site 445985001796 glycine-pyridoxal phosphate binding site [chemical binding]; other site 445985001797 active site 445985001798 folate binding site [chemical binding]; other site 445985001799 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 445985001800 HSP70 interaction site [polypeptide binding]; other site 445985001801 Borrelia burgdorferi attachment protein P66; Region: Attachment_P66; pfam11263 445985001802 L-lactate permease; Region: Lactate_perm; cl00701 445985001803 glycolate transporter; Provisional; Region: PRK09695 445985001804 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 445985001805 Beta-lactamase; Region: Beta-lactamase; cl01009 445985001806 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 445985001807 CheD chemotactic sensory transduction; Region: CheD; cl00810 445985001808 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 445985001809 UvrD/REP helicase; Region: UvrD-helicase; cl14126 445985001810 UvrD/REP helicase; Region: UvrD-helicase; cl14126 445985001811 aminoacyl-histidine dipeptidase; Region: aa-his-dipept; TIGR01893 445985001812 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 445985001813 metal binding site [ion binding]; metal-binding site 445985001814 dimer interface [polypeptide binding]; other site 445985001815 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 445985001816 oligomer interface [polypeptide binding]; other site 445985001817 active site residues [active] 445985001818 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 445985001819 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 445985001820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985001821 Walker A motif; other site 445985001822 ATP binding site [chemical binding]; other site 445985001823 Walker B motif; other site 445985001824 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 445985001825 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 445985001826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985001827 Walker A motif; other site 445985001828 ATP binding site [chemical binding]; other site 445985001829 Walker B motif; other site 445985001830 arginine finger; other site 445985001831 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 445985001832 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 445985001833 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 445985001834 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 445985001835 RNA binding surface [nucleotide binding]; other site 445985001836 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 445985001837 Cation efflux family; Region: Cation_efflux; cl00316 445985001838 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 445985001839 DHH family; Region: DHH; pfam01368 445985001840 DHHA1 domain; Region: DHHA1; pfam02272 445985001841 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 445985001842 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 445985001843 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 445985001844 conserved cys residue [active] 445985001845 Acetokinase family; Region: Acetate_kinase; cl01029 445985001846 transcription-repair coupling factor; Provisional; Region: PRK10689 445985001847 transcription-repair coupling factor; Region: mfd; TIGR00580 445985001848 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 445985001849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985001850 ATP binding site [chemical binding]; other site 445985001851 putative Mg++ binding site [ion binding]; other site 445985001852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985001853 nucleotide binding region [chemical binding]; other site 445985001854 ATP-binding site [chemical binding]; other site 445985001855 TRCF domain; Region: TRCF; pfam03461 445985001856 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 445985001857 putative peptidoglycan binding site; other site 445985001858 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 445985001859 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 445985001860 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 445985001861 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 445985001862 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 445985001863 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 445985001864 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 445985001865 active site 445985001866 metal binding site [ion binding]; metal-binding site 445985001867 M18 Peptidase aminopeptidase family; Region: M18; cd05639 445985001868 active site 445985001869 metal binding site [ion binding]; metal-binding site 445985001870 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 445985001871 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 445985001872 active site 445985001873 phosphorylation site [posttranslational modification] 445985001874 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 445985001875 P-loop; other site 445985001876 active site 445985001877 phosphorylation site [posttranslational modification] 445985001878 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 445985001879 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 445985001880 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 445985001881 putative substrate binding site [chemical binding]; other site 445985001882 putative ATP binding site [chemical binding]; other site 445985001883 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 445985001884 UvrD/REP helicase; Region: UvrD-helicase; cl14126 445985001885 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 445985001886 UvrD/REP helicase; Region: UvrD-helicase; cl14126 445985001887 UvrD/REP helicase; Region: UvrD-helicase; cl14126 445985001888 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 445985001889 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 445985001890 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 445985001891 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 445985001892 active site 445985001893 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 445985001894 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 445985001895 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 445985001896 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 445985001897 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 445985001898 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 445985001899 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 445985001900 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 445985001901 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 445985001902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 445985001903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 445985001904 dimer interface [polypeptide binding]; other site 445985001905 conserved gate region; other site 445985001906 putative PBP binding loops; other site 445985001907 ABC-ATPase subunit interface; other site 445985001908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 445985001909 dimer interface [polypeptide binding]; other site 445985001910 conserved gate region; other site 445985001911 putative PBP binding loops; other site 445985001912 ABC-ATPase subunit interface; other site 445985001913 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 445985001914 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985001915 Walker A/P-loop; other site 445985001916 ATP binding site [chemical binding]; other site 445985001917 Q-loop/lid; other site 445985001918 ABC transporter signature motif; other site 445985001919 Walker B; other site 445985001920 D-loop; other site 445985001921 H-loop/switch region; other site 445985001922 TOBE domain; Region: TOBE_2; cl01440 445985001923 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 445985001924 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 445985001925 GTP/Mg2+ binding site [chemical binding]; other site 445985001926 G4 box; other site 445985001927 G5 box; other site 445985001928 G1 box; other site 445985001929 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 445985001930 Switch I region; other site 445985001931 G2 box; other site 445985001932 G3 box; other site 445985001933 Switch II region; other site 445985001934 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 445985001935 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 445985001936 putative active site cavity [active] 445985001937 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 445985001938 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 445985001939 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 445985001940 active site turn [active] 445985001941 phosphorylation site [posttranslational modification] 445985001942 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 445985001943 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 445985001944 metal binding site 2 [ion binding]; metal-binding site 445985001945 putative DNA binding helix; other site 445985001946 metal binding site 1 [ion binding]; metal-binding site 445985001947 structural Zn2+ binding site [ion binding]; other site 445985001948 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 445985001949 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 445985001950 ring oligomerisation interface [polypeptide binding]; other site 445985001951 ATP/Mg binding site [chemical binding]; other site 445985001952 stacking interactions; other site 445985001953 hinge regions; other site 445985001954 protein-export membrane protein SecD; Region: secD; TIGR01129 445985001955 Protein export membrane protein; Region: SecD_SecF; cl14618 445985001956 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 445985001957 Protein export membrane protein; Region: SecD_SecF; cl14618 445985001958 chaperone protein DnaJ; Provisional; Region: PRK14299 445985001959 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 445985001960 HSP70 interaction site [polypeptide binding]; other site 445985001961 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 445985001962 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 445985001963 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 445985001964 tetramer (dimer of dimers) interface [polypeptide binding]; other site 445985001965 active site 445985001966 dimer interface [polypeptide binding]; other site 445985001967 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 445985001968 catalytic core [active] 445985001969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 445985001970 lysyl-tRNA synthetase, archaeal and spirochete; Region: lysS_arch; TIGR00467 445985001971 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 445985001972 active site 445985001973 HIGH motif; other site 445985001974 KMSKS motif; other site 445985001975 GTPase Era; Reviewed; Region: era; PRK00089 445985001976 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 445985001977 G1 box; other site 445985001978 GTP/Mg2+ binding site [chemical binding]; other site 445985001979 Switch I region; other site 445985001980 G2 box; other site 445985001981 Switch II region; other site 445985001982 G3 box; other site 445985001983 G4 box; other site 445985001984 G5 box; other site 445985001985 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 445985001986 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 445985001987 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 445985001988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 445985001989 active site 445985001990 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 445985001991 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 445985001992 active site 445985001993 metal binding site [ion binding]; metal-binding site 445985001994 Sporulation and spore germination; Region: Germane; pfam10646 445985001995 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 445985001996 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 445985001997 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 445985001998 putative binding surface; other site 445985001999 active site 445985002000 P2 response regulator binding domain; Region: P2; pfam07194 445985002001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 445985002002 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 445985002003 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 445985002004 putative CheA interaction surface; other site 445985002005 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 445985002006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985002007 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 445985002008 CheC-like family; Region: CheC; pfam04509 445985002009 Response regulator receiver domain; Region: Response_reg; pfam00072 445985002010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 445985002011 active site 445985002012 phosphorylation site [posttranslational modification] 445985002013 intermolecular recognition site; other site 445985002014 dimerization interface [polypeptide binding]; other site 445985002015 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 445985002016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 445985002017 motif II; other site 445985002018 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 445985002019 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 445985002020 Walker A/P-loop; other site 445985002021 ATP binding site [chemical binding]; other site 445985002022 Q-loop/lid; other site 445985002023 ABC transporter signature motif; other site 445985002024 Walker B; other site 445985002025 D-loop; other site 445985002026 H-loop/switch region; other site 445985002027 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985002028 Walker A/P-loop; other site 445985002029 ATP binding site [chemical binding]; other site 445985002030 Q-loop/lid; other site 445985002031 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 445985002032 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 445985002033 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 445985002034 TM-ABC transporter signature motif; other site 445985002035 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 445985002036 TM-ABC transporter signature motif; other site 445985002037 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 445985002038 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 445985002039 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 445985002040 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 445985002041 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 445985002042 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 445985002043 Ligand Binding Site [chemical binding]; other site 445985002044 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 445985002045 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 445985002046 dimer interface [polypeptide binding]; other site 445985002047 active site 445985002048 isopentenyl-diphosphate delta-isomerase, type 2; Region: IPP_isom_2; TIGR02151 445985002049 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 445985002050 homotetramer interface [polypeptide binding]; other site 445985002051 FMN binding site [chemical binding]; other site 445985002052 homodimer contacts [polypeptide binding]; other site 445985002053 putative active site [active] 445985002054 putative substrate binding site [chemical binding]; other site 445985002055 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 445985002056 homodimer interface [polypeptide binding]; other site 445985002057 NAD binding site [chemical binding]; other site 445985002058 catalytic residues [active] 445985002059 substrate binding pocket [chemical binding]; other site 445985002060 flexible flap; other site 445985002061 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 445985002062 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 445985002063 Phosphomevalonate kinase [Lipid metabolism]; Region: ERG8; COG3890 445985002064 mevalonate kinase; Region: mevalon_kin; TIGR00549 445985002065 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 445985002066 Ferritin-like domain; Region: Ferritin; pfam00210 445985002067 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 445985002068 dimerization interface [polypeptide binding]; other site 445985002069 DPS ferroxidase diiron center [ion binding]; other site 445985002070 ion pore; other site 445985002071 elongation factor G; Reviewed; Region: PRK13351 445985002072 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 445985002073 G1 box; other site 445985002074 putative GEF interaction site [polypeptide binding]; other site 445985002075 GTP/Mg2+ binding site [chemical binding]; other site 445985002076 Switch I region; other site 445985002077 G2 box; other site 445985002078 G3 box; other site 445985002079 Switch II region; other site 445985002080 G4 box; other site 445985002081 G5 box; other site 445985002082 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 445985002083 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 445985002084 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 445985002085 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 445985002086 signal recognition particle protein; Provisional; Region: PRK10867 445985002087 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 445985002088 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 445985002089 P loop; other site 445985002090 GTP binding site [chemical binding]; other site 445985002091 Signal peptide binding domain; Region: SRP_SPB; pfam02978 445985002092 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 445985002093 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 445985002094 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14594 445985002095 RimM N-terminal domain; Region: RimM; pfam01782 445985002096 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 445985002097 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 445985002098 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445985002099 active site 445985002100 nucleotide binding site [chemical binding]; other site 445985002101 HIGH motif; other site 445985002102 KMSKS motif; other site 445985002103 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 445985002104 Phosphopantetheine attachment site; Region: PP-binding; cl09936 445985002105 ribonuclease III; Reviewed; Region: rnc; PRK00102 445985002106 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 445985002107 dimerization interface [polypeptide binding]; other site 445985002108 active site 445985002109 metal binding site [ion binding]; metal-binding site 445985002110 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 445985002111 dsRNA binding site [nucleotide binding]; other site 445985002112 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 445985002113 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 445985002114 active site 445985002115 NTP binding site [chemical binding]; other site 445985002116 metal binding triad [ion binding]; metal-binding site 445985002117 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 445985002118 YceG-like family; Region: YceG; pfam02618 445985002119 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 445985002120 dimerization interface [polypeptide binding]; other site 445985002121 DNA primase, catalytic core; Region: dnaG; TIGR01391 445985002122 CHC2 zinc finger; Region: zf-CHC2; cl02597 445985002123 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 445985002124 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 445985002125 active site 445985002126 metal binding site [ion binding]; metal-binding site 445985002127 interdomain interaction site; other site 445985002128 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 445985002129 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 445985002130 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 445985002131 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 445985002132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 445985002133 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 445985002134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 445985002135 DNA binding residues [nucleotide binding] 445985002136 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 445985002137 Putative zinc ribbon domain; Region: DUF164; pfam02591 445985002138 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 445985002139 Cell division protein FtsA; Region: FtsA; cl11496 445985002140 rod shape-determining protein MreC; Region: mreC; TIGR00219 445985002141 rod shape-determining protein MreC; Region: MreC; pfam04085 445985002142 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 445985002143 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 445985002144 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 445985002145 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 445985002146 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 445985002147 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 445985002148 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 445985002149 active site 445985002150 dimer interface [polypeptide binding]; other site 445985002151 motif 1; other site 445985002152 motif 2; other site 445985002153 motif 3; other site 445985002154 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 445985002155 anticodon binding site; other site 445985002156 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 445985002157 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 445985002158 putative active site [active] 445985002159 putative metal binding residues [ion binding]; other site 445985002160 signature motif; other site 445985002161 putative triphosphate binding site [ion binding]; other site 445985002162 dimer interface [polypeptide binding]; other site 445985002163 Cation transport protein; Region: TrkH; cl10514 445985002164 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 445985002165 Cation transport protein; Region: TrkH; cl10514 445985002166 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 445985002167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445985002168 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 445985002169 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 445985002170 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 445985002171 P-loop; other site 445985002172 6-phosphofructokinase; Provisional; Region: PRK03202 445985002173 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 445985002174 active site 445985002175 ADP/pyrophosphate binding site [chemical binding]; other site 445985002176 dimerization interface [polypeptide binding]; other site 445985002177 allosteric effector site; other site 445985002178 fructose-1,6-bisphosphate binding site; other site 445985002179 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 445985002180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 445985002181 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 445985002182 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 445985002183 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 445985002184 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 445985002185 active site 445985002186 dimer interface [polypeptide binding]; other site 445985002187 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 445985002188 dimer interface [polypeptide binding]; other site 445985002189 active site 445985002190 ParB-like nuclease domain; Region: ParBc; cl02129 445985002191 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 445985002192 Transglycosylase; Region: Transgly; cl07896 445985002193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 445985002194 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 445985002195 SUA5 domain; Region: SUA5; pfam03481 445985002196 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 445985002197 rare lipoprotein A; Region: rlpA; TIGR00413 445985002198 Sporulation related domain; Region: SPOR; cl10051 445985002199 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 445985002200 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 445985002201 FMN binding site [chemical binding]; other site 445985002202 active site 445985002203 catalytic residues [active] 445985002204 substrate binding site [chemical binding]; other site 445985002205 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 445985002206 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445985002207 active site 445985002208 HIGH motif; other site 445985002209 nucleotide binding site [chemical binding]; other site 445985002210 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 445985002211 active site 445985002212 KMSKS motif; other site 445985002213 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 445985002214 tRNA binding surface [nucleotide binding]; other site 445985002215 anticodon binding site; other site 445985002216 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 445985002217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 445985002218 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 445985002219 oligomerisation interface [polypeptide binding]; other site 445985002220 mobile loop; other site 445985002221 roof hairpin; other site 445985002222 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 445985002223 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985002224 Walker A/P-loop; other site 445985002225 ATP binding site [chemical binding]; other site 445985002226 Q-loop/lid; other site 445985002227 ABC transporter signature motif; other site 445985002228 Walker B; other site 445985002229 D-loop; other site 445985002230 H-loop/switch region; other site 445985002231 ABC transporter; Region: ABC_tran_2; pfam12848 445985002232 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 445985002233 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 445985002234 FOG: WD40-like repeat [Function unknown]; Region: COG1520 445985002235 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 445985002236 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 445985002237 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 445985002238 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 445985002239 minor groove reading motif; other site 445985002240 helix-hairpin-helix signature motif; other site 445985002241 substrate binding pocket [chemical binding]; other site 445985002242 active site 445985002243 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 445985002244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 445985002245 ABC-ATPase subunit interface; other site 445985002246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 445985002247 Septum formation initiator; Region: DivIC; cl11433 445985002248 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 445985002249 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 445985002250 ABC-2 type transporter; Region: ABC2_membrane; cl11417 445985002251 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 445985002252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985002253 Walker A/P-loop; other site 445985002254 ATP binding site [chemical binding]; other site 445985002255 Q-loop/lid; other site 445985002256 ABC transporter signature motif; other site 445985002257 Walker B; other site 445985002258 D-loop; other site 445985002259 H-loop/switch region; other site 445985002260 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 445985002261 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 445985002262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 445985002263 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 445985002264 oligomer interface [polypeptide binding]; other site 445985002265 active site residues [active] 445985002266 Domain of unknown function (DUF368); Region: DUF368; cl00893 445985002267 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 445985002268 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 445985002269 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 445985002270 putative peptidoglycan binding site; other site 445985002271 Peptidase family M23; Region: Peptidase_M23; pfam01551 445985002272 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 445985002273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 445985002274 active site 445985002275 phosphorylation site [posttranslational modification] 445985002276 intermolecular recognition site; other site 445985002277 dimerization interface [polypeptide binding]; other site 445985002278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985002279 Walker A motif; other site 445985002280 ATP binding site [chemical binding]; other site 445985002281 Walker B motif; other site 445985002282 arginine finger; other site 445985002283 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 445985002284 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812 445985002285 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812 445985002286 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985002287 Colicin V production protein; Region: Colicin_V; cl00567 445985002288 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 445985002289 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 445985002290 homodimer interface [polypeptide binding]; other site 445985002291 active site 445985002292 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 445985002293 dimer interface [polypeptide binding]; other site 445985002294 pyridoxal binding site [chemical binding]; other site 445985002295 ATP binding site [chemical binding]; other site 445985002296 UGMP family protein; Validated; Region: PRK09604 445985002297 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 445985002298 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721 445985002299 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 445985002300 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 445985002301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 445985002302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 445985002303 Rod binding protein; Region: Rod-binding; cl01626 445985002304 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 445985002305 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 445985002306 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 445985002307 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 445985002308 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 445985002309 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 445985002310 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 445985002311 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 445985002312 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 445985002313 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 445985002314 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 445985002315 Protein of unknown function (DUF464); Region: DUF464; cl01080 445985002316 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 445985002317 GTPase CgtA; Reviewed; Region: obgE; PRK12299 445985002318 GTP1/OBG; Region: GTP1_OBG; pfam01018 445985002319 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 445985002320 G1 box; other site 445985002321 GTP/Mg2+ binding site [chemical binding]; other site 445985002322 Switch I region; other site 445985002323 G2 box; other site 445985002324 G3 box; other site 445985002325 Switch II region; other site 445985002326 G4 box; other site 445985002327 G5 box; other site 445985002328 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 445985002329 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 445985002330 active site 445985002331 (T/H)XGH motif; other site 445985002332 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 445985002333 Domain of unknown function DUF143; Region: DUF143; cl00519 445985002334 SpoVG; Region: SpoVG; cl00915 445985002335 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 445985002336 5S rRNA interface [nucleotide binding]; other site 445985002337 CTC domain interface; other site 445985002338 L16 interface [polypeptide binding]; other site 445985002339 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 445985002340 putative active site [active] 445985002341 catalytic residue [active] 445985002342 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 445985002343 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 445985002344 Ligand Binding Site [chemical binding]; other site 445985002345 FtsH Extracellular; Region: FtsH_ext; pfam06480 445985002346 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 445985002347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985002348 Walker A motif; other site 445985002349 ATP binding site [chemical binding]; other site 445985002350 Walker B motif; other site 445985002351 arginine finger; other site 445985002352 Peptidase family M41; Region: Peptidase_M41; pfam01434 445985002353 Thymidine kinase; Region: TK; cl00631 445985002354 thymidylate kinase; Region: DTMP_kinase; TIGR00041 445985002355 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 445985002356 TMP-binding site; other site 445985002357 ATP-binding site [chemical binding]; other site 445985002358 Family of unknown function (DUF490); Region: DUF490; pfam04357 445985002359 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 445985002360 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 445985002361 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 445985002362 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 445985002363 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 445985002364 Surface antigen; Region: Bac_surface_Ag; cl03097 445985002365 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 445985002366 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 445985002367 MutS domain I; Region: MutS_I; pfam01624 445985002368 MutS domain II; Region: MutS_II; pfam05188 445985002369 MutS family domain IV; Region: MutS_IV; pfam05190 445985002370 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 445985002371 Walker A/P-loop; other site 445985002372 ATP binding site [chemical binding]; other site 445985002373 Q-loop/lid; other site 445985002374 ABC transporter signature motif; other site 445985002375 Walker B; other site 445985002376 D-loop; other site 445985002377 H-loop/switch region; other site 445985002378 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 445985002379 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 445985002380 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 445985002381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 445985002382 transcription termination factor NusA; Region: NusA; TIGR01953 445985002383 NusA N-terminal domain; Region: NusA_N; pfam08529 445985002384 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 445985002385 RNA binding site [nucleotide binding]; other site 445985002386 homodimer interface [polypeptide binding]; other site 445985002387 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 445985002388 G-X-X-G motif; other site 445985002389 transcription termination factor Rho; Provisional; Region: PRK12678 445985002390 Plasmodium Vir superfamily; Provisional; Region: PTZ00473 445985002391 translation initiation factor IF-2; Region: IF-2; TIGR00487 445985002392 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 445985002393 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 445985002394 G1 box; other site 445985002395 putative GEF interaction site [polypeptide binding]; other site 445985002396 GTP/Mg2+ binding site [chemical binding]; other site 445985002397 Switch I region; other site 445985002398 G2 box; other site 445985002399 G3 box; other site 445985002400 Switch II region; other site 445985002401 G4 box; other site 445985002402 G5 box; other site 445985002403 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 445985002404 Translation-initiation factor 2; Region: IF-2; pfam11987 445985002405 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 445985002406 Ribosome-binding factor A; Region: RBFA; cl00542 445985002407 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 445985002408 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 445985002409 RNA binding site [nucleotide binding]; other site 445985002410 active site 445985002411 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 445985002412 16S/18S rRNA binding site [nucleotide binding]; other site 445985002413 S13e-L30e interaction site [polypeptide binding]; other site 445985002414 25S rRNA binding site [nucleotide binding]; other site 445985002415 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 445985002416 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 445985002417 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 445985002418 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 445985002419 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 445985002420 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 445985002421 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 445985002422 putative nucleic acid binding region [nucleotide binding]; other site 445985002423 G-X-X-G motif; other site 445985002424 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 445985002425 RNA binding site [nucleotide binding]; other site 445985002426 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 445985002427 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 445985002428 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 445985002429 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 445985002430 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 445985002431 integral membrane protein MviN; Region: mviN; TIGR01695 445985002432 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 445985002433 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic; Region: coaBC_dfp; TIGR00521 445985002434 Flavoprotein; Region: Flavoprotein; cl08021 445985002435 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 445985002436 Protein of unknown function (DUF997); Region: DUF997; cl01614 445985002437 Sodium:solute symporter family; Region: SSF; cl00456 445985002438 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 445985002439 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 445985002440 active site 445985002441 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 445985002442 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445985002443 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445985002444 TIGR00255 family protein; Region: TIGR00255 445985002445 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 445985002446 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 445985002447 cytidylate kinase; Provisional; Region: PRK04182 445985002448 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 445985002449 CMP-binding site; other site 445985002450 The sites determining sugar specificity; other site 445985002451 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 445985002452 IPP transferase; Region: IPPT; cl00403 445985002453 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 445985002454 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 445985002455 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985002456 ATP binding site [chemical binding]; other site 445985002457 putative Mg++ binding site [ion binding]; other site 445985002458 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985002459 nucleotide binding region [chemical binding]; other site 445985002460 ATP-binding site [chemical binding]; other site 445985002461 Helicase associated domain (HA2); Region: HA2; cl04503 445985002462 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 445985002463 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 445985002464 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 445985002465 active site 445985002466 interdomain interaction site; other site 445985002467 putative metal-binding site [ion binding]; other site 445985002468 nucleotide binding site [chemical binding]; other site 445985002469 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 445985002470 domain I; other site 445985002471 phosphate binding site [ion binding]; other site 445985002472 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 445985002473 domain III; other site 445985002474 nucleotide binding site [chemical binding]; other site 445985002475 DNA binding groove [nucleotide binding] 445985002476 catalytic site [active] 445985002477 domain II; other site 445985002478 domain IV; other site 445985002479 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 445985002480 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 445985002481 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 445985002482 active site 445985002483 metal binding site [ion binding]; metal-binding site 445985002484 DNA binding site [nucleotide binding] 445985002485 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 445985002486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985002487 Walker A/P-loop; other site 445985002488 ATP binding site [chemical binding]; other site 445985002489 Q-loop/lid; other site 445985002490 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985002491 ABC transporter signature motif; other site 445985002492 Walker B; other site 445985002493 D-loop; other site 445985002494 H-loop/switch region; other site 445985002495 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 445985002496 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 445985002497 HIGH motif; other site 445985002498 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 445985002499 active site 445985002500 KMSKS motif; other site 445985002501 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 445985002502 tRNA binding surface [nucleotide binding]; other site 445985002503 anticodon binding site; other site 445985002504 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 445985002505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 445985002506 Walker A motif; other site 445985002507 ATP binding site [chemical binding]; other site 445985002508 Walker B motif; other site 445985002509 arginine finger; other site 445985002510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985002511 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 445985002512 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 445985002513 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 445985002514 active site 445985002515 substrate binding site [chemical binding]; other site 445985002516 metal binding site [ion binding]; metal-binding site 445985002517 excinuclease ABC subunit B; Provisional; Region: PRK05298 445985002518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985002519 ATP binding site [chemical binding]; other site 445985002520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985002521 nucleotide binding region [chemical binding]; other site 445985002522 ATP-binding site [chemical binding]; other site 445985002523 Ultra-violet resistance protein B; Region: UvrB; pfam12344 445985002524 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 445985002525 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 445985002526 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 445985002527 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 445985002528 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 445985002529 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 445985002530 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 445985002531 RNA/DNA hybrid binding site [nucleotide binding]; other site 445985002532 active site 445985002533 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 445985002534 Amidinotransferase; Region: Amidinotransf; cl12043 445985002535 ornithine carbamoyltransferase; Provisional; Region: PRK04284 445985002536 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 445985002537 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 445985002538 Uncharacterized conserved protein [Function unknown]; Region: COG4748 445985002539 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 445985002540 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985002541 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002542 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002543 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002544 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985002545 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985002546 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985002547 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985002548 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985002549 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985002550 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985002551 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985002552 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985002553 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985002554 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985002555 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 445985002556 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985002557 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002558 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 445985002559 Mlp lipoprotein family; Region: Mlp; pfam03304 445985002560 ERF superfamily; Region: ERF; pfam04404 445985002561 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002562 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002563 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002564 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002565 P-loop; other site 445985002566 Magnesium ion binding site [ion binding]; other site 445985002567 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002568 Magnesium ion binding site [ion binding]; other site 445985002569 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002570 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 445985002571 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 445985002572 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985002573 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002574 Phage integrase family; Region: Phage_integrase; pfam00589 445985002575 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 445985002576 DNA binding site [nucleotide binding] 445985002577 Int/Topo IB signature motif; other site 445985002578 active site 445985002579 catalytic residues [active] 445985002580 Erp protein C-terminus; Region: Erp_C; pfam06780 445985002581 Protein of unknown function (DUF643); Region: DUF643; pfam04867 445985002582 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985002583 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985002584 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002585 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002586 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002587 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985002588 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985002589 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985002590 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985002591 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985002592 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985002593 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985002594 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985002595 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985002596 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985002597 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985002598 DUF276; Region: DUF276; pfam03434 445985002599 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985002600 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985002601 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 445985002602 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985002603 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002604 Borrelia burgdorferi REV protein; Region: Borrelia_REV; pfam03978 445985002605 Mlp lipoprotein family; Region: Mlp; pfam03304 445985002606 ERF superfamily; Region: ERF; pfam04404 445985002607 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002608 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002609 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002610 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002611 P-loop; other site 445985002612 Magnesium ion binding site [ion binding]; other site 445985002613 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002614 Magnesium ion binding site [ion binding]; other site 445985002615 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002616 membrane glycoprotein; Provisional; Region: PHA03332 445985002617 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 445985002618 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985002619 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002620 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 445985002621 Int/Topo IB signature motif; other site 445985002622 active site 445985002623 catalytic residues [active] 445985002624 DNA binding site [nucleotide binding] 445985002625 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 445985002626 Protein of unknown function (DUF643); Region: DUF643; pfam04867 445985002627 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985002628 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985002629 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002630 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002631 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002632 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985002633 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985002634 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985002635 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985002636 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985002637 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985002638 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985002639 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985002640 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985002641 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985002642 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985002643 DUF276; Region: DUF276; pfam03434 445985002644 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985002645 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985002646 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 445985002647 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985002648 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002649 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 445985002650 Mlp lipoprotein family; Region: Mlp; pfam03304 445985002651 ERF superfamily; Region: ERF; pfam04404 445985002652 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002653 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002654 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002655 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002656 P-loop; other site 445985002657 Magnesium ion binding site [ion binding]; other site 445985002658 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002659 Magnesium ion binding site [ion binding]; other site 445985002660 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002661 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 445985002662 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985002663 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002664 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 445985002665 DNA binding site [nucleotide binding] 445985002666 Int/Topo IB signature motif; other site 445985002667 active site 445985002668 catalytic residues [active] 445985002669 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 445985002670 Erp protein C-terminus; Region: Erp_C; pfam06780 445985002671 Protein of unknown function (DUF643); Region: DUF643; pfam04867 445985002672 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985002673 Protein of unknown function (DUF541); Region: SIMPL; cl01077 445985002674 adenine deaminase; Region: ade; TIGR01178 445985002675 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 445985002676 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295 445985002677 active site 445985002678 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 445985002679 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 445985002680 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002681 Magnesium ion binding site [ion binding]; other site 445985002682 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002683 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002684 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002685 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 445985002686 hypothetical protein; Provisional; Region: PRK12472 445985002687 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002688 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002689 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002690 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002691 P-loop; other site 445985002692 Magnesium ion binding site [ion binding]; other site 445985002693 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002694 Magnesium ion binding site [ion binding]; other site 445985002695 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002696 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 445985002697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 445985002698 Phage terminase large subunit; Region: Terminase_3; cl12054 445985002699 Transcription factor Tfb2; Region: Tfb2; cl04289 445985002700 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002701 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002702 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002703 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002704 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 445985002706 Walker A motif; other site 445985002707 ATP binding site [chemical binding]; other site 445985002708 Walker B motif; other site 445985002709 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002710 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002711 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002712 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 445985002713 P loop; other site 445985002714 Nucleotide binding site [chemical binding]; other site 445985002715 DTAP/Switch II; other site 445985002716 Switch I; other site 445985002717 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002718 Magnesium ion binding site [ion binding]; other site 445985002719 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002720 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 445985002721 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 445985002722 Probable transposase; Region: OrfB_IS605; pfam01385 445985002723 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002724 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002725 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002726 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002727 P-loop; other site 445985002728 Magnesium ion binding site [ion binding]; other site 445985002729 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002730 Magnesium ion binding site [ion binding]; other site 445985002731 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002732 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002733 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 445985002734 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002735 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002736 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002737 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002738 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002739 P-loop; other site 445985002740 Magnesium ion binding site [ion binding]; other site 445985002741 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 445985002742 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002743 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002744 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002745 P-loop; other site 445985002746 Magnesium ion binding site [ion binding]; other site 445985002747 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002748 Magnesium ion binding site [ion binding]; other site 445985002749 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002750 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002751 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 445985002752 metal binding site [ion binding]; metal-binding site 445985002753 catalytic triad [active] 445985002754 conserved cis-peptide bond; other site 445985002755 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002756 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 445985002757 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985002758 DUF276; Region: DUF276; pfam03434 445985002759 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985002760 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985002761 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985002762 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002763 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 445985002764 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 445985002765 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002766 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002767 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 445985002768 P-loop; other site 445985002769 Magnesium ion binding site [ion binding]; other site 445985002770 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002771 Magnesium ion binding site [ion binding]; other site 445985002772 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002773 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002774 Decorin binding protein; Region: Decorin_bind; pfam02352 445985002775 Decorin binding protein; Region: Decorin_bind; pfam02352 445985002776 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985002777 Phage terminase large subunit; Region: Terminase_3; cl12054 445985002778 Terminase-like family; Region: Terminase_6; pfam03237 445985002779 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985002780 peptide binding site [polypeptide binding]; other site 445985002781 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 445985002782 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 445985002783 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002784 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985002785 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985002786 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985002787 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985002788 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985002789 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985002790 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985002791 na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844 445985002792 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002793 Herpes virus major outer envelope glycoprotein (BLLF1); Region: Herpes_BLLF1; pfam05109 445985002794 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002795 OMS28 porin; Region: OMS28_porin; pfam03532 445985002796 Thymidylate synthase complementing protein; Region: Thy1; cl03630 445985002797 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002798 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 445985002799 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002800 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002801 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002802 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002803 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002804 P-loop; other site 445985002805 Magnesium ion binding site [ion binding]; other site 445985002806 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 445985002807 Magnesium ion binding site [ion binding]; other site 445985002808 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002809 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002810 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002811 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 445985002812 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002