-- dump date 20120504_135144 -- class Genbank::CDS -- table cds_note -- id note YP_063244.1 catalyzes the hydrolysis of acylphosphate YP_063245.1 similar to Borrelia burgdorferi BBB02, identity 0.851 YP_063246.1 similar to Borrelia burgdorferi BBB03, identity 0.931 YP_063247.1 similar to Borrelia burgdorferi BBB04, identity 0.955 YP_063248.1 similar to Borrelia burgdorferi BBB05, identity 0.913 YP_063249.1 similar to Borrelia burgdorferi BBB06, identity 0.933 YP_063250.1 similar to Borrelia burgdorferi BBB07, identity 0.951 YP_063251.1 similar to Borrelia burgdorferi BBB08, identity 0.773 YP_063252.1 similar to Borrelia burgdorferi BBB09, identity 0.898 YP_063253.1 similar to Borrelia burgdorferi BBB10, identity 0.845 YP_063254.1 similar to Borrelia burgdorferi BBB11, identity 0.895 YP_063255.1 similar to Borrelia burgdorferi BBB12, identity 0.905 YP_063256.1 similar to Borrelia burgdorferi BBB13, identity 0.857 YP_063257.1 similar to Borrelia burgdorferi BBB14, identity 0.873 YP_063258.1 similar to Borrelia burgdorferi BBB16, identity 0.885 YP_063259.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_063260.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_063261.1 similar to Borrelia burgdorferi BBB19, identity 0.7 YP_063262.1 similar to Borrelia burgdorferi BBB22, identity 0.962 YP_063263.1 similar to Borrelia burgdorferi BBB23, identity 0.92 YP_063264.1 similar to Borrelia burgdorferi BBB24, identity 0.857 YP_063265.1 similar to Borrelia burgdorferi BBB25, identity 0.944 YP_063266.1 similar to Borrelia burgdorferi BBB26, identity 0.887 YP_063267.1 similar to Borrelia burgdorferi BBB27, identity 0.902 YP_063268.1 similar to Borrelia burgdorferi BBB28, identity 0.91 YP_063269.1 similar to Borrelia burgdorferi BBB29, identity 0.956 YP_063270.1 similar to Borrelia burgdorferi BBA01, identity 0.86 YP_063271.1 similar to Borrelia burgdorferi BBA03, identity 0.71 YP_063272.1 similar to Borrelia burgdorferi BBA04, identity 0.74 YP_063273.1 similar to Borrelia burgdorferi BBA05, identity 0.8 YP_063274.1 similar to Borrelia burgdorferi BBA07, identity 0.85 YP_063275.1 similar to Borrelia burgdorferi BBA08, identity 0.88 YP_063276.1 similar to Borrelia burgdorferi BBA09, identity 0.86 YP_063278.1 similar to Borrelia burgdorferi BBA10, identity 0.92 YP_063279.1 similar to Borrelia burgdorferi BBA11, identity 0.78 YP_063280.1 similar to Borrelia burgdorferi BBA12, identity 0.81 YP_063281.1 similar to Borrelia burgdorferi BBA13, identity 0.86 YP_063282.1 similar to Borrelia burgdorferi BBA14, identity 0.91 YP_063283.1 similar to Borrelia burgdorferi BBA15, identity 0.8 YP_063284.1 similar to Borrelia burgdorferi BBA16, identity 0.66 YP_063285.1 similar to Borrelia burgdorferi BBA18, identity 0.85 YP_063286.1 similar to Borrelia burgdorferi BBA19, identity 0.94 YP_063287.1 similar to Borrelia burgdorferi BBA20, identity 0.95 YP_063288.1 similar to Borrelia burgdorferi BBA21, identity 0.92 YP_063289.1 similar to Borrelia burgdorferi BBA23, identity 0.77 YP_063290.1 similar to Borrelia burgdorferi BBA24, identity 0.46 YP_063291.1 similar to Borrelia burgdorferi BBA25, identity 0.64 YP_063292.1 similar to Borrelia burgdorferi BBA28, identity 0.68 YP_063293.1 similar to Borrelia burgdorferi BBA31, identity 0.91 YP_063296.1 similar to Borrelia burgdorferi BBA33, identity 0.79 YP_063297.1 similar to Borrelia burgdorferi BBA34, identity 0.83 YP_063299.1 similar to Borrelia burgdorferi BBA36, identity 0.67 YP_063300.1 similar to Borrelia burgdorferi BBA37, identity 0.74 YP_063302.1 similar to Borrelia burgdorferi BBA38, identity 0.9 YP_063303.1 similar to Borrelia burgdorferi BBA39, identity 0.74 YP_063305.1 similar to Borrelia burgdorferi BBA40, identity 0.85 YP_063306.1 similar to Borrelia burgdorferi BBA41, identity 0.9 YP_063307.1 similar to Borrelia burgdorferi BBA42, identity 0.76 YP_063308.1 similar to Borrelia burgdorferi BBA43, identity 0.82 YP_063309.1 similar to Borrelia burgdorferi BBA44, identity 0.8 YP_063311.1 similar to Borrelia burgdorferi BBA45, identity 0.86 YP_063313.1 similar to Borrelia burgdorferi BBA46, identity 0.85 YP_063314.1 similar to Borrelia burgdorferi BBA47, identity 0.92 YP_063315.1 similar to Borrelia burgdorferi BBA48, identity 0.87 YP_063317.1 similar to Borrelia burgdorferi BBA50, identity 0.67 YP_063319.1 similar to Borrelia burgdorferi BBA51, identity 0.89 YP_063320.1 similar to Borrelia burgdorferi BBA52, identity 0.7 YP_063321.1 similar to Borrelia burgdorferi BBA53, identity 0.75 YP_063322.1 similar to Borrelia burgdorferi BBA54, identity 0.75 YP_063324.1 similar to Borrelia burgdorferi BBA55, identity 0.82 YP_063325.1 similar to Borrelia burgdorferi BBA56, identity 0.92 YP_063327.1 similar to Borrelia burgdorferi BBA57, identity 0.68 YP_063328.1 similar to Borrelia burgdorferi BBA59, identity 0.68 YP_063329.1 similar to Borrelia burgdorferi BBA60, identity 0.66 YP_063330.1 similar to Borrelia burgdorferi BBA61, identity 0.82 YP_063331.1 similar to Borrelia burgdorferi BBA62, identity 0.7 YP_063332.1 similar to Borrelia burgdorferi BBA64, identity 0.67 YP_063333.1 similar to Borrelia burgdorferi BBA65, identity 0.7 YP_063334.1 similar to Borrelia burgdorferi BBA66, identity 0.48 YP_063335.1 similar to Borrelia burgdorferi BBA68, identity 0.52 YP_063336.1 similar to Borrelia burgdorferi BBA69, identity 0.41 YP_063337.1 similar to Borrelia burgdorferi BBA70, identity 0.39 YP_063339.1 similar to Borrelia burgdorferi BBA72, identity 0.55 YP_063341.1 similar to Borrelia burgdorferi BBA71, identity 0.34 YP_063342.1 similar to Borrelia burgdorferi BBA73, identity 0.58 YP_063343.1 similar to Borrelia burgdorferi BBA74, identity 0.88 YP_072453.1 ortholog to Borrelia burgdorferi BB0002 YP_072454.1 ortholog to Borrelia burgdorferi BB0003 YP_072455.1 ortholog to Borrelia burgdorferi BB0004 YP_072456.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_072457.1 ortholog to Borrelia burgdorferi BB0006 YP_072458.1 ortholog to Borrelia burgdorferi BB0007 YP_072459.1 ortholog to Borrelia burgdorferi BB0008 YP_072460.1 ortholog to Borrelia burgdorferi BB0009 YP_072461.1 ortholog to Borrelia burgdorferi BB0010 YP_072462.1 ortholog to Borrelia burgdorferi BB0011 YP_072463.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_072464.1 ortholog to Borrelia burgdorferi BB0013 YP_072465.1 ortholog to Borrelia burgdorferi BB0014 YP_072466.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_072467.1 ortholog to Borrelia burgdorferi BB0016 YP_072468.1 ortholog to Borrelia burgdorferi BB0017 YP_072469.1 ortholog to Borrelia burgdorferi BB0018 YP_072470.1 ortholog to Borrelia burgdorferi BB0019 YP_072471.1 catalyzes the formation of fructose 1,6-bisphosphate from fructose 6-phosphate and diphosphate YP_072472.1 ortholog to Borrelia burgdorferi BB0021 YP_072473.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_072474.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_072475.1 ortholog to Borrelia burgdorferi BB0024 YP_072476.1 ortholog to Borrelia burgdorferi BB0025 YP_072477.1 ortholog to Borrelia burgdorferi BB0026 YP_072478.1 ortholog to Borrelia burgdorferi BB0027 YP_072479.1 ortholog to Borrelia burgdorferi BB0028 YP_072480.1 ortholog to Borrelia burgdorferi BB0029 YP_072481.1 ortholog to Borrelia burgdorferi BB0030 YP_072482.1 ortholog to Borrelia burgdorferi BB0031 YP_072483.1 ortholog to Borrelia burgdorferi BB0032 YP_072484.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_072485.1 ortholog to Borrelia burgdorferi BB0034 YP_072486.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_072487.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_072488.1 ortholog to Borrelia burgdorferi BB0037 YP_072489.1 ortholog to Borrelia burgdorferi BB0038 YP_072490.1 ortholog to Borrelia burgdorferi BB0039 YP_072491.1 ortholog to Borrelia burgdorferi BB0040 YP_072492.1 ortholog to Borrelia burgdorferi BB0042 YP_072493.1 ortholog to Borrelia burgdorferi BB0043 YP_072494.1 ortholog to Borrelia burgdorferi BB0044 YP_072495.1 ortholog to Borrelia burgdorferi BB0045 YP_072496.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_072497.1 ortholog to Borrelia burgdorferi BB0047 YP_072498.1 ortholog to Borrelia burgdorferi BB0049 YP_072499.1 ortholog to Borrelia burgdorferi BB0050 YP_072500.1 ortholog to Borrelia burgdorferi BB0051 YP_072501.1 ortholog to Borrelia burgdorferi BB0052 YP_072502.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_072503.1 ortholog to Borrelia burgdorferi BB0054 YP_072504.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_072505.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_072506.1 ortholog to Borrelia burgdorferi BB0057 YP_072507.1 ortholog to Borrelia burgdorferi BB0058 YP_072508.1 ortholog to Borrelia burgdorferi BB0059 YP_072509.1 ortholog to Borrelia burgdorferi BB0060 YP_072510.1 ortholog to Borrelia burgdorferi BB0061 YP_072511.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_072512.1 ortholog to Borrelia burgdorferi BB0063 YP_072513.1 ortholog to Borrelia burgdorferi BB0064 YP_072514.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_072515.1 ortholog to Borrelia burgdorferi BB0066 YP_072516.1 ortholog to Borrelia burgdorferi BB0067 YP_072517.1 ortholog to Borrelia burgdorferi BB0068 YP_072518.1 ortholog to Borrelia burgdorferi BB0069 YP_072519.1 ortholog to Borrelia burgdorferi BB0070 YP_072520.1 ortholog to Borrelia burgdorferi BB0071 YP_072521.1 ortholog to Borrelia burgdorferi BB0072 YP_072522.1 ortholog to Borrelia burgdorferi BB0073 YP_072523.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_072524.1 ortholog to Borrelia burgdorferi BB0075 YP_072525.1 ortholog to Borrelia burgdorferi BB0076 YP_072526.1 ortholog to Borrelia burgdorferi BB0077 YP_072527.1 fused from Borrelia burgdorferi BB0078 and BB0079 YP_072528.1 ortholog to Borrelia burgdorferi BB0080 YP_072529.1 ortholog to Borrelia burgdorferi BB0081 YP_072530.1 ortholog to Borrelia burgdorferi BB0082 YP_072531.1 ortholog to Borrelia burgdorferi BB0083 YP_072532.1 ortholog to Borrelia burgdorferi BB0084 YP_072534.1 ortholog to Borrelia burgdorferi BB0085 YP_072536.1 split from Borrelia burgdorferi BB0086 YP_072537.1 split from Borrelia burgdorferi BB0086 YP_072538.1 ortholog to Borrelia burgdorferi BB0087 YP_072539.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_072540.1 ortholog to Borrelia burgdorferi BB0089 YP_072541.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits YP_072542.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel. YP_072543.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex YP_072544.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex YP_072545.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex YP_072546.1 ortholog to Borrelia burgdorferi BB0095 YP_072547.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the E subunit is part of the catalytic core of the ATP synthase complex YP_072548.1 ortholog to Borrelia burgdorferi BB0097 YP_072549.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_072550.1 ortholog to Borrelia burgdorferi BB0099 YP_072551.1 ortholog to Borrelia burgdorferi BB0100 YP_072552.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_072553.1 ortholog to Borrelia burgdorferi BB0102 YP_072554.1 ortholog to Borrelia burgdorferi BB0103 YP_072555.1 ortholog to Borrelia burgdorferi BB0104 YP_072556.1 ortholog to Borrelia burgdorferi BB0105 YP_072557.1 ortholog to Borrelia burgdorferi BB0106 YP_072558.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_072559.1 ortholog to Borrelia burgdorferi BB0108 YP_072560.1 ortholog to Borrelia burgdorferi BB0109 YP_072561.1 ortholog to Borrelia burgdorferi BB0110 YP_072562.1 ortholog to Borrelia burgdorferi BB0111 YP_072563.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_072564.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_072565.1 ortholog to Borrelia burgdorferi BB0114 YP_072566.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_072567.1 ortholog to Borrelia burgdorferi BB0116 YP_072568.1 ortholog to Borrelia burgdorferi BB0117 YP_072569.1 ortholog to Borrelia burgdorferi BB0118 YP_072570.1 ortholog to Borrelia burgdorferi BB0119 YP_072571.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_072572.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_072573.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_072574.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_072575.1 ortholog to Borrelia burgdorferi BB0124 YP_072577.1 ortholog to Borrelia burgdorferi BB0125 YP_072578.1 ortholog to Borrelia burgdorferi BB0126 YP_072579.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_072580.1 ortholog to Borrelia burgdorferi BB0128 YP_072581.1 ortholog to Borrelia burgdorferi BB0129 YP_072582.1 ortholog to Borrelia burgdorferi BB0130 YP_072583.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_072584.1 contains N-terminal domain of unknown function fused to transcription elongation factor; GreA is necessary for efficient RNA polymerization through arresting sites; cleaves the nascent transcript and allows resumption of transcription elongation YP_072585.1 ortholog to Borrelia burgdorferi BB0133 YP_072586.1 ortholog to Borrelia burgdorferi BB0134 YP_072587.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_072588.1 ortholog to Borrelia burgdorferi BB0136 YP_072589.1 ortholog to Borrelia burgdorferi BB0137 YP_072590.1 ortholog to Borrelia burgdorferi BB0139 YP_072591.1 ortholog to Borrelia burgdorferi BB0140 YP_072592.1 ortholog to Borrelia burgdorferi BB0141 YP_072593.1 ortholog to Borrelia burgdorferi BB0142 YP_072594.1 ortholog to Borrelia burgdorferi BB0144 YP_072595.1 ortholog to Borrelia burgdorferi BB0145 YP_072596.1 ortholog to Borrelia burgdorferi BB0146 YP_072597.1 structural flagella protein YP_072598.1 involved in flagellin assembly YP_072599.1 ortholog to Borrelia burgdorferi BB0151 YP_072600.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_072601.1 ortholog to Borrelia burgdorferi BB0153 YP_072602.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_072603.1 ortholog to Borrelia burgdorferi BB0155 YP_072604.1 ortholog to Borrelia burgdorferi BB0156 YP_072605.1 ortholog to Borrelia burgdorferi BB0157 YP_072606.1 ortholog to Borrelia burgdorferi BB0158 YP_072607.1 ortholog to Borrelia burgdorferi BB0159 YP_072608.1 ortholog to Borrelia burgdorferi BB0160 YP_072609.1 ortholog to Borrelia burgdorferi BB0161 YP_072610.1 ortholog to Borrelia burgdorferi BB0162 YP_072611.1 ortholog to Borrelia burgdorferi BB0163 YP_072612.1 ortholog to Borrelia burgdorferi BB0164 YP_072613.1 ortholog to Borrelia burgdorferi BB0165 YP_072614.1 amylomaltase; acts to release glucose from maltodextrins YP_072615.1 ortholog to Borrelia burgdorferi BB0167 YP_072617.1 ortholog to Borrelia burgdorferi BB0168 YP_072618.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_072619.1 ortholog to Borrelia burgdorferi BB0170 YP_072620.1 ortholog to Borrelia burgdorferi BB0171 YP_072621.1 ortholog to Borrelia burgdorferi BB0172 YP_072622.1 ortholog to Borrelia burgdorferi BB0173 YP_072623.1 ortholog to Borrelia burgdorferi BB0174 YP_072624.1 ortholog to Borrelia burgdorferi BB0175 YP_072625.1 ortholog to Borrelia burgdorferi BB0176 YP_072626.1 ortholog to Borrelia burgdorferi BB0177 YP_072627.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_072628.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_072629.1 ortholog to Borrelia burgdorferi BB0180 YP_072630.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_072631.1 With FlgK acts as a hook filament junction protein to join the flagellar filament to the hook YP_072632.1 binds to flagellin and appears to stabilize flagellin during flagella assembly YP_072633.1 ortholog to Borrelia burgdorferi BB0184 YP_072634.1 ortholog to Borrelia burgdorferi BB0185 YP_072635.1 ortholog to Borrelia burgdorferi BB0186 YP_072636.1 ortholog to Borrelia burgdorferi BB0187 YP_072637.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_072638.1 ortholog to Borrelia burgdorferi BB0189 YP_072639.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_072641.1 ortholog to Borrelia burgdorferi BB0193 YP_072642.1 ortholog to Borrelia burgdorferi BB0194 YP_072643.1 ortholog to Borrelia burgdorferi BB0195 YP_072644.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_072645.1 ortholog to Borrelia burgdorferi BB0197 YP_072646.1 ortholog to Borrelia burgdorferi BB0198 YP_072647.1 ortholog to Borrelia burgdorferi BB0199 YP_072649.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_072650.1 ortholog to Borrelia burgdorferi BB0201 YP_072651.1 ortholog to Borrelia burgdorferi BB0202 YP_072652.1 ortholog to Borrelia burgdorferi BB0203 YP_072653.1 ortholog to Borrelia burgdorferi BB0204 YP_072654.1 ortholog to Borrelia burgdorferi BB0205 YP_072655.1 ortholog to Borrelia burgdorferi BB0206 YP_072656.1 ortholog to Borrelia burgdorferi BB0207 YP_072657.1 ortholog to Borrelia burgdorferi BB0208 YP_072658.1 ortholog to Borrelia burgdorferi BB0209 YP_072659.1 similar to Borrelia burgdorferi BB0210 YP_072660.1 ortholog to Borrelia burgdorferi BB0211 YP_072661.1 ortholog to Borrelia burgdorferi BB0212 YP_072662.1 ortholog to Borrelia burgdorferi BB0213 YP_072663.1 ortholog to Borrelia burgdorferi BB0214 YP_072664.1 ortholog to Borrelia burgdorferi BB0215 YP_072665.1 ortholog to Borrelia burgdorferi BB0216 YP_072666.1 ortholog to Borrelia burgdorferi BB0217 YP_072667.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_072668.1 ortholog to Borrelia burgdorferi BB0219 YP_072669.1 catalyzes a two-step reaction, first charging an alanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_072670.1 ortholog to Borrelia burgdorferi BB0221 YP_072671.1 ortholog to Borrelia burgdorferi BB0222 YP_072673.1 ortholog to Borrelia burgdorferi BB0224 YP_072674.1 ortholog to Borrelia burgdorferi BB0225 YP_072675.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_072676.1 ortholog to Borrelia burgdorferi BB0227 YP_072677.1 ortholog to Borrelia burgdorferi BB0228 YP_072678.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_072679.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_072680.1 ortholog to Borrelia burgdorferi BB0231 YP_072681.1 ortholog to Borrelia burgdorferi BB0232 YP_072682.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_072683.1 ortholog to Borrelia burgdorferi BB0234 YP_072684.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_072685.1 ortholog to Borrelia burgdorferi BB0236 YP_072686.1 Transfers the fatty acyl group on membrane lipoproteins YP_072687.1 ortholog to Borrelia burgdorferi BB0238 YP_072688.1 ortholog to Borrelia burgdorferi BB0239 YP_072689.1 ortholog to Borrelia burgdorferi BB0240 YP_072690.1 ortholog to Borrelia burgdorferi BB0241 YP_072691.1 ortholog to Borrelia burgdorferi BB0243 YP_072692.1 ortholog to Borrelia burgdorferi BB0244 YP_072693.1 ortholog to Borrelia burgdorferi BB0245 YP_072694.1 ortholog to Borrelia burgdorferi BB0246 YP_072695.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_072696.1 ortholog to Borrelia burgdorferi BB0248 YP_072697.1 ortholog to Borrelia burgdorferi BB0249 YP_072698.1 ortholog to Borrelia burgdorferi BB0250 YP_072699.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_072700.1 ortholog to Borrelia burgdorferi BB0252 YP_072701.1 ortholog to Borrelia burgdorferi BB0253 YP_072702.1 ortholog to Borrelia burgdorferi BB0254 YP_072703.1 ortholog to Borrelia burgdorferi BB0255 YP_072704.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_072705.1 ortholog to Borrelia burgdorferi BB0257 YP_072706.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_072707.1 ortholog to Borrelia burgdorferi BB0259 YP_072708.1 ortholog to Borrelia burgdorferi BB0260 YP_072709.1 ortholog to Borrelia burgdorferi BB0261 YP_072710.1 ortholog to Borrelia burgdorferi BB0262 YP_072711.1 ortholog to Borrelia burgdorferi BB0263 YP_072712.1 ortholog to Borrelia burgdorferi BB0264 YP_072713.1 ortholog to Borrelia burgdorferi BB0265 YP_072714.1 ortholog to Borrelia burgdorferi BB0266 YP_072715.1 ortholog to Borrelia burgdorferi BB0267 YP_072716.1 ortholog to Borrelia burgdorferi BB0268 YP_072717.1 ortholog to Borrelia burgdorferi BB0269 YP_072718.1 Positive regulator of class III flagellar genes YP_072719.1 membrane protein involved in the flagellar export apparatus YP_072720.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_072721.1 ortholog to Borrelia burgdorferi BB0273 YP_072722.1 ortholog to Borrelia burgdorferi BB0274 YP_072723.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_072724.1 possible structural component of the flagellum that anchors the rod to the membrane YP_072725.1 ortholog to Borrelia burgdorferi BB0277 YP_072726.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_072727.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_072728.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_072729.1 ortholog to Borrelia burgdorferi BB0281 YP_072730.1 ortholog to Borrelia burgdorferi BB0282 YP_072731.1 the hook connects flagellar basal body to the flagellar filament YP_072732.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod YP_072733.1 ortholog to Borrelia burgdorferi BB0285 YP_072734.1 ortholog to Borrelia burgdorferi BB0286 YP_072735.1 ortholog to Borrelia burgdorferi BB0287 YP_072736.1 ortholog to Borrelia burgdorferi BB0288 YP_072737.1 binds to and inhibits the function of flagella specific ATPase FliI YP_072738.1 One of three proteins involved in switching the direction of the flagellar rotation YP_072739.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_072740.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_072741.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_072742.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod YP_072743.1 heat shock protein involved in degradation of misfolded proteins YP_072744.1 heat shock protein involved in degradation of misfolded proteins YP_072746.1 ortholog to Borrelia burgdorferi BB0297 YP_072747.1 ortholog to Borrelia burgdorferi BB0298 YP_072748.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_072749.1 ortholog to Borrelia burgdorferi BB0300 YP_072750.1 ortholog to Borrelia burgdorferi BB0301 YP_072751.1 ortholog to Borrelia burgdorferi BB0302 YP_072752.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_072753.1 ortholog to Borrelia burgdorferi BB0304 YP_072754.1 ortholog to Borrelia burgdorferi BB0305 YP_072755.1 ortholog to Borrelia burgdorferi BB0306 YP_072756.1 ortholog to Borrelia burgdorferi BB0307 YP_072757.1 ortholog to Borrelia burgdorferi BB0308 YP_072758.1 ortholog to Borrelia burgdorferi BB0309 YP_072759.1 ortholog to Borrelia burgdorferi BB0311 YP_072760.1 ortholog to Borrelia burgdorferi BB0312 YP_072761.1 ortholog to Borrelia burgdorferi BB0313 YP_072762.1 ortholog to Borrelia burgdorferi BB0314 YP_072763.1 ortholog to Borrelia burgdorferi BB0315 YP_072764.1 ortholog to Borrelia burgdorferi BB0316 YP_072765.1 ortholog to Borrelia burgdorferi BB0317 YP_072766.1 ortholog to Borrelia burgdorferi BB0318 YP_072767.1 ortholog to Borrelia burgdorferi BB0319 YP_072768.1 ortholog to Borrelia burgdorferi BB0322 YP_072769.1 ortholog to Borrelia burgdorferi BB0323 YP_072770.1 ortholog to Borrelia burgdorferi BB0324 YP_072771.1 ortholog to Borrelia burgdorferi BB0325 YP_072772.1 ortholog to Borrelia burgdorferi BB0326 YP_072773.1 ortholog to Borrelia burgdorferi BB0327 YP_072774.1 ortholog to Borrelia burgdorferi BB0328 YP_072775.1 ortholog to Borrelia burgdorferi BB0329 YP_072776.1 ortholog to Borrelia burgdorferi BB0330 YP_072777.1 ortholog to Borrelia burgdorferi BB0332 YP_072778.1 ortholog to Borrelia burgdorferi BB0333 YP_072780.1 ortholog to Borrelia burgdorferi BB0334 YP_072781.1 ortholog to Borrelia burgdorferi BB0335 YP_072782.1 ortholog to Borrelia burgdorferi BB0336 YP_072783.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_072784.1 forms a direct contact with the tRNA during translation YP_072785.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_072786.1 ortholog to Borrelia burgdorferi BB0340 YP_072787.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_072788.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_072789.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_072790.1 ortholog to Borrelia burgdorferi BB0344 YP_072791.1 ortholog to Borrelia burgdorferi BB0345 YP_072792.1 ortholog to Borrelia burgdorferi BB0346 YP_072793.1 ortholog to Borrelia burgdorferi BB0347 YP_072794.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_072795.1 ortholog to Borrelia burgdorferi BB0349 YP_072796.1 required for 70S ribosome assembly YP_072797.1 ortholog to Borrelia burgdorferi BB0351 YP_072798.1 ortholog to Borrelia burgdorferi BB0352 YP_072799.1 ortholog to Borrelia burgdorferi BB0353 YP_072800.1 ortholog to Borrelia burgdorferi BB0354 YP_072801.1 ortholog to Borrelia burgdorferi BB0355 YP_072802.1 fused from Borrelia burgdorferi BB0356 and BB0357 YP_072803.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_072804.1 ortholog to Borrelia burgdorferi BB0359 YP_072805.1 ortholog to Borrelia burgdorferi BB0361 YP_072806.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_072807.1 ortholog to Borrelia burgdorferi BB0363 YP_072808.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_072809.1 ortholog to Borrelia burgdorferi BB0365 YP_072810.1 catalyzes the removal of amino acids from the N termini of peptides YP_072811.1 ortholog to Borrelia burgdorferi BB0367 YP_072812.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_072813.1 ortholog to Borrelia burgdorferi BB0369 YP_072814.1 ortholog to Borrelia burgdorferi BB0370 YP_072815.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_072816.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_072817.1 ortholog to Borrelia burgdorferi BB0373 YP_072818.1 ortholog to Borrelia burgdorferi BB0374 YP_072819.1 ortholog to Borrelia burgdorferi BB0375 YP_072820.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_072821.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_072822.1 ortholog to Borrelia burgdorferi BB0378 YP_072823.1 ortholog to Borrelia burgdorferi BB0379 YP_072824.1 ortholog to Borrelia burgdorferi BB0380 YP_072825.1 ortholog to Borrelia burgdorferi BB0381 YP_072826.1 ortholog to Borrelia burgdorferi BB0382 YP_072827.1 ortholog to Borrelia burgdorferi BB0383 YP_072828.1 ortholog to Borrelia burgdorferi BB0383 YP_072829.1 ortholog to Borrelia burgdorferi BB0384 YP_072830.1 ortholog to Borrelia burgdorferi BB0385 YP_072831.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_072832.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_072833.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_072834.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_072835.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_072836.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_072837.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_072838.1 binds directly to 23S ribosomal RNA YP_072839.1 ortholog to Borrelia burgdorferi BB0394 YP_072840.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_072841.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_072842.1 ortholog to Borrelia burgdorferi BB0397 YP_072843.1 ortholog to Borrelia burgdorferi BB0398 YP_072844.1 ortholog to Borrelia burgdorferi BB0399 YP_072845.1 ortholog to Borrelia burgdorferi BB0400 YP_072846.1 ortholog to Borrelia burgdorferi BB0401 YP_072847.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_072848.1 ortholog to Borrelia burgdorferi BB0403 YP_072849.1 ortholog to Borrelia burgdorferi BB0405 YP_072850.1 ortholog to Borrelia burgdorferi BB0406 YP_072851.1 ortholog to Borrelia burgdorferi BB0407 YP_072852.1 ortholog to Borrelia burgdorferi BB0408 YP_072853.1 ortholog to Borrelia burgdorferi BB0409 YP_072854.1 fused from Borrelia burgdorferi BB0410 and BB0411 YP_072855.1 ortholog to Borrelia burgdorferi BB0412 YP_072856.1 ortholog to Borrelia burgdorferi BB0413 YP_072858.1 ortholog to Borrelia burgdorferi BB0414 YP_072860.1 ortholog to Borrelia burgdorferi BB0415 YP_072861.1 ortholog to Borrelia burgdorferi BB0416 YP_072862.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_072863.1 ortholog to Borrelia burgdorferi BB0418 YP_072864.1 ortholog to Borrelia burgdorferi BB0419 YP_072865.1 ortholog to Borrelia burgdorferi BB0420 YP_072866.1 ortholog to Borrelia burgdorferi BB0421 YP_072867.1 ortholog to Borrelia burgdorferi BB0422 YP_072869.1 ortholog to Borrelia burgdorferi BB0426 YP_072870.1 ortholog to Borrelia burgdorferi BB0427 YP_072871.1 ortholog to Borrelia burgdorferi BB0428 YP_072872.1 ortholog to Borrelia burgdorferi BB0429 YP_072873.1 ortholog to Borrelia burgdorferi BB0430 YP_072874.1 ortholog to Borrelia burgdorferi BB0431 YP_072875.1 ortholog to Borrelia burgdorferi BB0432 YP_072876.1 ortholog to Borrelia burgdorferi BB0434 YP_072877.1 ortholog to Borrelia burgdorferi BB0435 YP_072878.1 ortholog to Borrelia burgdorferi BB0436 YP_072879.1 ortholog to Borrelia burgdorferi BB0437 YP_072880.1 ortholog to Borrelia burgdorferi BB0438 YP_072881.1 ortholog to Borrelia burgdorferi BB0439 YP_072882.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_072883.1 ortholog to Borrelia burgdorferi BB0441 YP_072884.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_072885.1 ortholog to Borrelia burgdorferi BB0443 YP_072887.1 ortholog to Borrelia burgdorferi BB0444 YP_072888.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_072889.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_072890.1 ortholog to Borrelia burgdorferi BB0447 YP_072891.1 ortholog to Borrelia burgdorferi BB0448 YP_072892.1 ortholog to Borrelia burgdorferi BB0449 YP_072893.1 ortholog to Borrelia burgdorferi BB0450 YP_072894.1 ortholog to Borrelia burgdorferi BB0451 YP_072896.1 ortholog to Borrelia burgdorferi BB0452 YP_072897.1 ortholog to Borrelia burgdorferi BB0453 YP_072898.1 ortholog to Borrelia burgdorferi BB0454 YP_072899.1 ortholog to Borrelia burgdorferi BB0455 YP_072900.1 ortholog to Borrelia burgdorferi BB0456 YP_072901.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_072902.1 ortholog to Borrelia burgdorferi BB0458 YP_072903.1 ortholog to Borrelia burgdorferi BB0459 YP_072904.1 ortholog to Borrelia burgdorferi BB0460 YP_072905.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_072906.1 ortholog to Borrelia burgdorferi BB0462 YP_072907.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_072908.1 ortholog to Borrelia burgdorferi BB0464 YP_072909.1 ortholog to Borrelia burgdorferi BB0465 YP_072910.1 ortholog to Borrelia burgdorferi BB0466 YP_072911.1 ortholog to Borrelia burgdorferi BB0467 YP_072912.1 ortholog to Borrelia burgdorferi BB0468 YP_072913.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_072914.1 ortholog to Borrelia burgdorferi BB0471 YP_072915.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_072916.1 ortholog to Borrelia burgdorferi BB0473 YP_072917.1 similar to Borrelia burgdorferi BB0475 YP_072918.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_072919.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_072920.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_072921.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_072923.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_072924.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_072925.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_072926.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_072927.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_072928.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_072929.1 one of the stabilizing components for the large ribosomal subunit YP_072930.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_072931.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_072932.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_072933.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_072934.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_072935.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_072936.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_072937.1 binds 5S rRNA along with protein L5 and L25 YP_072938.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_072939.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_072940.1 late assembly protein YP_072941.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_072942.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_072943.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_072944.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_072945.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_072946.1 is a component of the macrolide binding site in the peptidyl transferase center YP_072947.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_072948.1 ortholog to Borrelia burgdorferi BB0505 YP_072949.1 ortholog to Borrelia burgdorferi BB0506 YP_072950.1 ortholog to Borrelia burgdorferi BB0507 YP_072951.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_072952.1 ortholog to Borrelia burgdorferi BB0509 YP_072953.1 fused from Borrelia burgdorferi BB0510 and BB0511 YP_072954.1 ortholog to Borrelia burgdorferi BB0512 YP_072955.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_072956.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_072957.1 ortholog to Borrelia burgdorferi BB0515 YP_072958.1 ortholog to Borrelia burgdorferi BB0516 YP_072959.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_072960.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_072961.1 ortholog to Borrelia burgdorferi BB0519 YP_072962.1 fused from Borrelia burgdorferi BB0521 and BB0522 YP_072964.1 similar to Borrelia burgdorferi BB0524 YP_072965.1 ortholog to Borrelia burgdorferi BB0525 YP_072966.1 ortholog to Borrelia burgdorferi BB0526 YP_072967.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_072968.1 ortholog to Borrelia burgdorferi BB0528 YP_072969.1 ortholog to Borrelia burgdorferi BB0530 YP_072970.1 ortholog to Borrelia burgdorferi BB0531 YP_072971.1 similar to Borrelia burgdorferi BB0532 YP_072972.1 ortholog to Borrelia burgdorferi BB0533 YP_072973.1 ortholog to Borrelia burgdorferi BB0534 YP_072974.1 ortholog to Borrelia burgdorferi BB0535 YP_072975.1 ortholog to Borrelia burgdorferi BB0536 YP_072976.1 ortholog to Borrelia burgdorferi BB0537 YP_072977.1 ortholog to Borrelia burgdorferi BB0538 YP_072978.1 ortholog to Borrelia burgdorferi BB0539 YP_072979.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_072980.1 ortholog to Borrelia burgdorferi BB0541 YP_072981.1 ortholog to Borrelia burgdorferi BB0542 YP_072982.1 ortholog to Borrelia burgdorferi BB0543 YP_072983.1 Catalyzes the formation of PRPP from ATP and ribose 5-phosphate YP_072984.1 ortholog to Borrelia burgdorferi BB0545 YP_072985.1 similar to Borrelia burgdorferi BB0546 YP_072986.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_072987.1 ortholog to Borrelia burgdorferi BB0548 YP_072988.1 ortholog to Borrelia burgdorferi BB0549 YP_072989.1 ortholog to Borrelia burgdorferi BB0550 YP_072990.1 ortholog to Borrelia burgdorferi BB0551 YP_072991.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_072992.1 ortholog to Borrelia burgdorferi BB0553 YP_072993.1 ortholog to Borrelia burgdorferi BB0554 YP_072994.1 ortholog to Borrelia burgdorferi BB0555 YP_072995.1 ortholog to Borrelia burgdorferi BB0556 YP_072996.1 ortholog to Borrelia burgdorferi BB0557 YP_072997.1 ortholog to Borrelia burgdorferi BB0558 YP_072998.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_072999.1 molecular chaperone YP_073000.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_073001.1 ortholog to Borrelia burgdorferi BB0562 YP_073002.1 ortholog to Borrelia burgdorferi BB0563 YP_073003.1 ortholog to Borrelia burgdorferi BB0564 YP_073004.1 ortholog to Borrelia burgdorferi BB0565 YP_073005.1 ortholog to Borrelia burgdorferi BB0566 YP_073006.1 ortholog to Borrelia burgdorferi BB0567 YP_073007.1 ortholog to Borrelia burgdorferi BB0568 YP_073008.1 ortholog to Borrelia burgdorferi BB0569 YP_073009.1 ortholog to Borrelia burgdorferi BB0570 YP_073010.1 Catalyzes the phosphorylation of UMP to UDP YP_073011.1 ortholog to Borrelia burgdorferi BB0572 YP_073012.1 ortholog to Borrelia burgdorferi BB0573 YP_073013.1 ortholog to Borrelia burgdorferi BB0574 YP_073014.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_073015.1 ortholog to Borrelia burgdorferi BB0576 YP_073016.1 ortholog to Borrelia burgdorferi BB0577 YP_073018.1 ortholog to Borrelia burgdorferi BB0578 YP_073019.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_073020.1 ortholog to Borrelia burgdorferi BB0580 YP_073021.1 catalyzes branch migration in Holliday junction intermediates YP_073022.1 ortholog to Borrelia burgdorferi BB0582 YP_073023.1 ortholog to Borrelia burgdorferi BB0583 YP_073025.1 ortholog to Borrelia burgdorferi BB0584 YP_073026.1 ortholog to Borrelia burgdorferi BB0585 YP_073027.1 ortholog to Borrelia burgdorferi BB0586 YP_073028.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_073029.1 ortholog to Borrelia burgdorferi BB0588 YP_073030.1 ortholog to Borrelia burgdorferi BB0589 YP_073031.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_073032.1 similar to Borrelia burgdorferi BB0591 YP_073033.1 ortholog to Borrelia burgdorferi BB0592 YP_073034.1 ortholog to Borrelia burgdorferi BB0593 YP_073035.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_073037.1 ortholog to Borrelia burgdorferi BB0596 YP_073038.1 ortholog to Borrelia burgdorferi BB0597 YP_073039.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_073040.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_073041.1 ortholog to Borrelia burgdorferi BB0600 YP_073042.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_073043.1 ortholog to Borrelia burgdorferi BB0602 YP_073044.1 ortholog to Borrelia burgdorferi BB0603 YP_073045.1 ortholog to Borrelia burgdorferi BB0604 YP_073046.1 ortholog to Borrelia burgdorferi BB0605 YP_073047.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_073048.1 ortholog to Borrelia burgdorferi BB0607 YP_073049.1 ortholog to Borrelia burgdorferi BB0608 YP_073050.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_073051.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_073052.1 binds and unfolds substrates as part of the ClpXP protease YP_073053.1 ortholog to Borrelia burgdorferi BB0613 YP_073054.1 ortholog to Borrelia burgdorferi BB0614 YP_073056.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_073057.1 ortholog to Borrelia burgdorferi BB0616 YP_073058.1 ortholog to Borrelia burgdorferi BB0617 YP_073059.1 ortholog to Borrelia burgdorferi BB0618 YP_073060.1 ortholog to Borrelia burgdorferi BB0619 YP_073061.1 ortholog to Borrelia burgdorferi BB0620 YP_073062.1 ortholog to Borrelia burgdorferi BB0621 YP_073063.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_073064.1 ortholog to Borrelia burgdorferi BB0623 YP_073065.1 ortholog to Borrelia burgdorferi BB0624 YP_073066.1 ortholog to Borrelia burgdorferi BB0625 YP_073067.1 ortholog to Borrelia burgdorferi BB0626 YP_073069.1 catalyzes the removal of amino acids from the N termini of peptides YP_073070.1 ortholog to Borrelia burgdorferi BB0628 YP_073071.1 ortholog to Borrelia burgdorferi BB0629 YP_073072.1 ortholog to Borrelia burgdorferi BB0630 YP_073073.1 ortholog to Borrelia burgdorferi BB0631 YP_073074.1 ortholog to Borrelia burgdorferi BB0632 YP_073075.1 ortholog to Borrelia burgdorferi BB0633 YP_073076.1 ortholog to Borrelia burgdorferi BB0634 YP_073077.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_073078.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_073079.1 ortholog to Borrelia burgdorferi BB0637 YP_073081.1 ortholog to Borrelia burgdorferi BB0638 YP_073082.1 ortholog to Borrelia burgdorferi BB0639 YP_073083.1 ortholog to Borrelia burgdorferi BB0640 YP_073084.1 ortholog to Borrelia burgdorferi BB0641 YP_073085.1 ortholog to Borrelia burgdorferi BB0642 YP_073086.2 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_073087.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_073088.1 ortholog to Borrelia burgdorferi BB0645 YP_073089.1 ortholog to Borrelia burgdorferi BB0646 YP_073090.1 ortholog to Borrelia burgdorferi BB0647 YP_073091.1 ortholog to Borrelia burgdorferi BB0648 YP_073092.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_073093.1 ortholog to Borrelia burgdorferi BB0650 YP_073094.1 ortholog to Borrelia burgdorferi BB0651 YP_073095.2 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_073096.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_073097.1 ortholog to Borrelia burgdorferi BB0654 YP_073098.1 ortholog to Borrelia burgdorferi BB0655 YP_073099.1 ortholog to Borrelia burgdorferi BB0656 YP_073100.1 ortholog to Borrelia burgdorferi BB0657 YP_073101.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_073102.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine YP_073103.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_073104.1 ortholog to Borrelia burgdorferi BB0661 YP_073105.1 ortholog to Borrelia burgdorferi BB0662 YP_073106.1 ortholog to Borrelia burgdorferi BB0663 YP_073107.1 ortholog to Borrelia burgdorferi BB0664 YP_073108.1 ortholog to Borrelia burgdorferi BB0665 YP_073109.1 ortholog to Borrelia burgdorferi BB0666 YP_073110.1 ortholog to Borrelia burgdorferi BB0667 YP_073111.1 ortholog to Borrelia burgdorferi BB0668 YP_073112.1 ortholog to Borrelia burgdorferi BB0669 YP_073113.1 ortholog to Borrelia burgdorferi BB0670 YP_073114.1 ortholog to Borrelia burgdorferi BB0671 YP_073115.1 ortholog to Borrelia burgdorferi BB0672 YP_073116.1 ortholog to Borrelia burgdorferi BB0673 YP_073117.1 ortholog to Borrelia burgdorferi BB0674 YP_073118.1 ortholog to Borrelia burgdorferi BB0675 YP_073119.1 ortholog to Borrelia burgdorferi BB0676 YP_073120.1 ortholog to Borrelia burgdorferi BB0677 YP_073121.1 ortholog to Borrelia burgdorferi BB0678 YP_073122.1 ortholog to Borrelia burgdorferi BB0679 YP_073123.1 ortholog to Borrelia burgdorferi BB0680 YP_073124.1 ortholog to Borrelia burgdorferi BB0681 YP_073125.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_073126.1 ortholog to Borrelia burgdorferi BB0683 YP_073127.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_073128.1 ortholog to Borrelia burgdorferi BB0685 YP_073129.1 ortholog to Borrelia burgdorferi BB0686 YP_073130.1 ortholog to Borrelia burgdorferi BB0687 YP_073131.1 ortholog to Borrelia burgdorferi BB0688 YP_073132.1 ortholog to Borrelia burgdorferi BB0689 YP_073133.1 ortholog to Borrelia burgdorferi BB0690 YP_073134.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_073135.1 ortholog to Borrelia burgdorferi BB0693 YP_073136.1 ortholog to Borrelia burgdorferi BB0694 YP_073137.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_073138.1 ortholog to Borrelia burgdorferi BB0696 YP_073139.1 Essential for efficient processing of 16S rRNA YP_073140.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_073141.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_073142.1 ortholog to Borrelia burgdorferi BB0701 YP_073143.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_073144.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_073145.1 carries the fatty acid chain in fatty acid biosynthesis YP_073146.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_073147.1 ortholog to Borrelia burgdorferi BB0706 YP_073148.1 ortholog to Borrelia burgdorferi BB0707 YP_073149.1 ortholog to Borrelia burgdorferi BB0708 YP_073150.1 ortholog to Borrelia burgdorferi BB0709 YP_073151.1 fused from Borrelia burgdorferi BB0710 and BB0711 YP_073152.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_073153.1 ortholog to Borrelia burgdorferi BB0713 YP_073154.1 ortholog to Borrelia burgdorferi BB0714 YP_073155.1 functions in MreBCD complex in some organisms YP_073156.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_073157.1 ortholog to Borrelia burgdorferi BB0717 YP_073158.1 ortholog to Borrelia burgdorferi BB0718 YP_073159.1 ortholog to Borrelia burgdorferi BB0719 YP_073160.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_073161.1 ortholog to Borrelia burgdorferi BB0721 YP_073162.1 ortholog to Borrelia burgdorferi BB0722 YP_073163.1 ortholog to Borrelia burgdorferi BB0723 YP_073164.1 ortholog to Borrelia burgdorferi BB0724 YP_073165.1 ortholog to Borrelia burgdorferi BB0725 YP_073166.1 ortholog to Borrelia burgdorferi BB0726 YP_073167.1 catalyzes the formation of fructose 1,6-bisphosphate from fructose 6-phosphate and diphosphate YP_073168.1 CoADR; specific for coenzyme A disulfide; requires NADH; involved in protecting cells against reactive oxygen species by recycling coenzyme A disulfide which can reduce hydrogen peroxide YP_073169.1 ortholog to Borrelia burgdorferi BB0729 YP_073170.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_073171.1 ortholog to Borrelia burgdorferi BB0731 YP_073172.1 ortholog to Borrelia burgdorferi BB0732 YP_073173.1 ortholog to Borrelia burgdorferi BB0733 YP_073174.1 ortholog to Borrelia burgdorferi BB0734 YP_073175.1 ortholog to Borrelia burgdorferi BB0735 YP_073176.1 ortholog to Borrelia burgdorferi BB0737 YP_073177.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_073178.1 ortholog to Borrelia burgdorferi BB0739 YP_073179.1 ortholog to Borrelia burgdorferi BB0740 YP_073180.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_073181.1 ortholog to Borrelia burgdorferi BB0742 YP_073182.1 ortholog to Borrelia burgdorferi BB0743 YP_073183.1 ortholog to Borrelia burgdorferi BB0744 YP_073184.1 ortholog to Borrelia burgdorferi BB0745 YP_073185.1 ortholog to Borrelia burgdorferi BB0746 YP_073186.1 ortholog to Borrelia burgdorferi BB0747 YP_073187.1 ortholog to Borrelia burgdorferi BB0748 YP_073188.1 similar to Borrelia burgdorferi BB0749 YP_073189.1 ortholog to Borrelia burgdorferi BB0751 YP_073190.1 ortholog to Borrelia burgdorferi BB0752 YP_073191.1 ortholog to Borrelia burgdorferi BB0753 YP_073192.1 ortholog to Borrelia burgdorferi BB0754 YP_073193.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_073194.1 ortholog to Borrelia burgdorferi BB0756 YP_073195.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_073197.1 similar to Borrelia burgdorferi BB0758 YP_073198.1 ortholog to Borrelia burgdorferi BB0759 YP_073199.1 ortholog to Borrelia burgdorferi BB0760 YP_073200.1 ortholog to Borrelia burgdorferi BB0761 YP_073201.1 ortholog to Borrelia burgdorferi BB0763 YP_073202.1 ortholog to Borrelia burgdorferi BB0764 YP_073203.1 ortholog to Borrelia burgdorferi BB0765 YP_073204.1 ortholog to Borrelia burgdorferi BB0766 YP_073205.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_073206.1 ortholog to Borrelia burgdorferi BB0768 YP_073207.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_073208.1 ortholog to Borrelia burgdorferi BB0770 YP_073209.1 ortholog to Borrelia burgdorferi BB0771 YP_073211.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod YP_073212.1 ortholog to Borrelia burgdorferi BB0773 YP_073213.1 makes up the distal portion of the flagellar basal body rod YP_073214.1 ortholog to Borrelia burgdorferi BB0775 YP_073215.1 ortholog to Borrelia burgdorferi BB0776 YP_073216.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_073217.1 ortholog to Borrelia burgdorferi BB0778 YP_073218.1 ortholog to Borrelia burgdorferi BB0779 YP_073219.1 involved in the peptidyltransferase reaction during translation YP_073220.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_073221.1 ortholog to Borrelia burgdorferi BB0782 YP_073222.1 ortholog to Borrelia burgdorferi BB0783 YP_073223.1 ortholog to Borrelia burgdorferi BB0784 YP_073224.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_073225.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_073226.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_073227.1 ortholog to Borrelia burgdorferi BB0788 YP_073228.1 ortholog to Borrelia burgdorferi BB0789 YP_073229.1 ortholog to Borrelia burgdorferi BB0790 YP_073230.1 ortholog to Borrelia burgdorferi BB0791 YP_073232.1 ortholog to Borrelia burgdorferi BB0792 YP_073233.1 ortholog to Borrelia burgdorferi BB0793 YP_073234.1 ortholog to Borrelia burgdorferi BB0794 YP_073235.1 ortholog to Borrelia burgdorferi BB0795 YP_073236.1 ortholog to Borrelia burgdorferi BB0796 YP_073237.1 This protein performs the mismatch recognition step during the DNA repair process YP_073238.1 ortholog to Borrelia burgdorferi BB0798 YP_073239.1 ortholog to Borrelia burgdorferi BB0799 YP_073240.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_073241.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_073242.1 ortholog to Borrelia burgdorferi BB0802 YP_073243.1 ortholog to Borrelia burgdorferi BB0803 YP_073244.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_073245.1 ortholog to Borrelia burgdorferi BB0805 YP_073246.1 ortholog to Borrelia burgdorferi BB0806 YP_073247.1 ortholog to Borrelia burgdorferi BB0807 YP_073248.1 ortholog to Borrelia burgdorferi BB0808 YP_073249.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_073250.1 ortholog to Borrelia burgdorferi BB0810 YP_073251.1 ortholog to Borrelia burgdorferi BB0811 YP_073252.1 ortholog to Borrelia burgdorferi BB0812 YP_073253.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_073254.1 ortholog to Borrelia burgdorferi BB0815 YP_073255.1 ortholog to Borrelia burgdorferi BB0816 YP_073256.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_073257.1 ortholog to Borrelia burgdorferi BB0818 YP_073258.1 catalyzes the formation of (d)CDP from ATP and (d)CMP YP_073259.1 ortholog to Borrelia burgdorferi BB0820 YP_073260.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_073261.1 ortholog to Borrelia burgdorferi BB0823 YP_073262.1 ortholog to Borrelia burgdorferi BB0824 YP_073263.1 ortholog to Borrelia burgdorferi BB0825 YP_073265.1 ortholog to Borrelia burgdorferi BB0826 YP_073266.1 ortholog to Borrelia burgdorferi BB0827 YP_073267.1 ortholog to Borrelia burgdorferi BB0828 YP_073268.1 ortholog to Borrelia burgdorferi BB0829 YP_073269.1 ortholog to Borrelia burgdorferi BB0830 YP_073270.1 ortholog to Borrelia burgdorferi BB0831 YP_073271.1 ortholog to Borrelia burgdorferi BB0832 YP_073272.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_073273.1 ortholog to Borrelia burgdorferi BB0834 YP_073274.1 ortholog to Borrelia burgdorferi BB0835 YP_073275.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_073276.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_073277.1 ortholog to Borrelia burgdorferi BB0838 YP_073280.1 ortholog to Borrelia burgdorferi BB0839 YP_073281.1 ortholog to Borrelia burgdorferi BB0840 YP_073282.1 catalyzes the degradation of arginine to citruline and ammonia YP_073283.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation