-- dump date 20111121_010652 -- class Genbank::misc_feature -- table misc_feature_note -- id note 446465000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 446465000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465000003 Walker A motif; other site 446465000004 ATP binding site [chemical binding]; other site 446465000005 Walker B motif; other site 446465000006 arginine finger; other site 446465000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 446465000008 DnaA box-binding interface [nucleotide binding]; other site 446465000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 446465000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 446465000011 putative DNA binding surface [nucleotide binding]; other site 446465000012 dimer interface [polypeptide binding]; other site 446465000013 beta-clamp/clamp loader binding surface; other site 446465000014 beta-clamp/translesion DNA polymerase binding surface; other site 446465000015 recombination protein F; Reviewed; Region: recF; PRK00064 446465000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 446465000017 Walker A/P-loop; other site 446465000018 ATP binding site [chemical binding]; other site 446465000019 Q-loop/lid; other site 446465000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465000021 ABC transporter signature motif; other site 446465000022 Walker B; other site 446465000023 D-loop; other site 446465000024 H-loop/switch region; other site 446465000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 446465000026 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 446465000027 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 446465000028 catalytic motif [active] 446465000029 Zn binding site [ion binding]; other site 446465000030 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 446465000031 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 446465000032 Lumazine binding domain; Region: Lum_binding; pfam00677 446465000033 Lumazine binding domain; Region: Lum_binding; pfam00677 446465000034 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 446465000035 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 446465000036 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 446465000037 dimerization interface [polypeptide binding]; other site 446465000038 active site 446465000039 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 446465000040 homopentamer interface [polypeptide binding]; other site 446465000041 active site 446465000042 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 446465000043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465000044 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 446465000045 anchoring element; other site 446465000046 dimer interface [polypeptide binding]; other site 446465000047 ATP binding site [chemical binding]; other site 446465000048 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 446465000049 active site 446465000050 putative metal-binding site [ion binding]; other site 446465000051 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446465000052 DNA gyrase subunit A; Validated; Region: PRK05560 446465000053 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 446465000054 CAP-like domain; other site 446465000055 Active site [active] 446465000056 primary dimer interface [polypeptide binding]; other site 446465000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000062 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 446465000063 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 446465000064 putative deacylase active site [active] 446465000065 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 446465000066 Cupin domain; Region: Cupin_2; cl09118 446465000067 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446465000068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465000069 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 446465000070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000071 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465000072 NAD(P) binding site [chemical binding]; other site 446465000073 active site 446465000074 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446465000075 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446465000076 DNA binding residues [nucleotide binding] 446465000077 Ferredoxin [Energy production and conversion]; Region: COG1146 446465000078 4Fe-4S binding domain; Region: Fer4; cl02805 446465000079 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 446465000080 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446465000081 DNA binding residues [nucleotide binding] 446465000082 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446465000083 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446465000084 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446465000085 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446465000086 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 446465000087 Walker A/P-loop; other site 446465000088 ATP binding site [chemical binding]; other site 446465000089 Q-loop/lid; other site 446465000090 ABC transporter signature motif; other site 446465000091 Walker B; other site 446465000092 D-loop; other site 446465000093 H-loop/switch region; other site 446465000094 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446465000095 Histidine kinase; Region: HisKA_3; pfam07730 446465000096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465000097 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465000098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465000099 active site 446465000100 phosphorylation site [posttranslational modification] 446465000101 intermolecular recognition site; other site 446465000102 dimerization interface [polypeptide binding]; other site 446465000103 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 446465000104 DNA binding residues [nucleotide binding] 446465000105 dimerization interface [polypeptide binding]; other site 446465000106 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 446465000107 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 446465000108 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 446465000109 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 446465000110 active site 446465000111 multimer interface [polypeptide binding]; other site 446465000112 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 446465000113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465000114 DNA-binding site [nucleotide binding]; DNA binding site 446465000115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465000116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465000117 homodimer interface [polypeptide binding]; other site 446465000118 catalytic residue [active] 446465000119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 446465000120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 446465000121 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000123 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465000124 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000126 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446465000127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465000128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465000129 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 446465000130 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446465000131 TPP-binding site [chemical binding]; other site 446465000132 tetramer interface [polypeptide binding]; other site 446465000133 heterodimer interface [polypeptide binding]; other site 446465000134 phosphorylation loop region [posttranslational modification] 446465000135 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446465000136 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446465000137 alpha subunit interface [polypeptide binding]; other site 446465000138 TPP binding site [chemical binding]; other site 446465000139 heterodimer interface [polypeptide binding]; other site 446465000140 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465000141 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446465000142 E3 interaction surface; other site 446465000143 lipoyl attachment site [posttranslational modification]; other site 446465000144 e3 binding domain; Region: E3_binding; pfam02817 446465000145 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446465000146 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446465000147 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 446465000148 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 446465000149 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446465000150 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446465000151 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465000152 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 446465000153 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 446465000154 carboxyltransferase (CT) interaction site; other site 446465000155 biotinylation site [posttranslational modification]; other site 446465000156 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 446465000157 putative active site [active] 446465000158 putative catalytic site [active] 446465000159 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 446465000160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446465000161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465000162 active site 446465000163 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446465000164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465000165 DNA-binding site [nucleotide binding]; DNA binding site 446465000166 FCD domain; Region: FCD; cl11656 446465000167 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446465000168 nucleoside/Zn binding site; other site 446465000169 dimer interface [polypeptide binding]; other site 446465000170 catalytic motif [active] 446465000171 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446465000172 substrate binding site [chemical binding]; other site 446465000173 dimer interface [polypeptide binding]; other site 446465000174 catalytic triad [active] 446465000175 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 446465000176 dihydroxyacetone kinase; Provisional; Region: PRK14479 446465000177 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446465000178 DAK2 domain; Region: Dak2; cl03685 446465000179 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 446465000180 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465000181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465000182 classical (c) SDRs; Region: SDR_c; cd05233 446465000183 NAD(P) binding site [chemical binding]; other site 446465000184 active site 446465000185 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446465000186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000187 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446465000188 gluconate transporter; Region: gntP; TIGR00791 446465000189 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 446465000190 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 446465000191 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446465000192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000193 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465000194 classical (c) SDRs; Region: SDR_c; cd05233 446465000195 NAD(P) binding site [chemical binding]; other site 446465000196 active site 446465000197 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 446465000198 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 446465000199 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446465000200 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion...; Region: enolase_like; cl14814 446465000201 metal binding site [ion binding]; metal-binding site 446465000202 substrate binding pocket [chemical binding]; other site 446465000203 Domain of unknown function (DUF718); Region: DUF718; cl01281 446465000204 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465000205 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000206 active site 446465000207 catalytic tetrad [active] 446465000208 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 446465000209 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465000210 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465000211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465000212 DNA-binding site [nucleotide binding]; DNA binding site 446465000213 FCD domain; Region: FCD; cl11656 446465000214 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 446465000215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465000216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000217 dimer interface [polypeptide binding]; other site 446465000218 conserved gate region; other site 446465000219 putative PBP binding loops; other site 446465000220 ABC-ATPase subunit interface; other site 446465000221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465000222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465000223 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446465000224 peptide binding site [polypeptide binding]; other site 446465000225 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465000226 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465000227 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465000228 Walker A/P-loop; other site 446465000229 ATP binding site [chemical binding]; other site 446465000230 Q-loop/lid; other site 446465000231 ABC transporter signature motif; other site 446465000232 Walker B; other site 446465000233 D-loop; other site 446465000234 H-loop/switch region; other site 446465000235 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465000236 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465000237 Walker A/P-loop; other site 446465000238 ATP binding site [chemical binding]; other site 446465000239 Q-loop/lid; other site 446465000240 ABC transporter signature motif; other site 446465000241 Walker B; other site 446465000242 D-loop; other site 446465000243 H-loop/switch region; other site 446465000244 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465000245 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446465000246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465000247 DNA-binding site [nucleotide binding]; DNA binding site 446465000248 UTRA domain; Region: UTRA; cl06649 446465000249 Uncharacterized conserved protein [Function unknown]; Region: COG5476 446465000250 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 446465000251 MlrC C-terminus; Region: MlrC_C; pfam07171 446465000252 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 446465000253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465000254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000255 active site 446465000256 catalytic tetrad [active] 446465000257 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 446465000258 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 446465000259 NAD binding site [chemical binding]; other site 446465000260 sugar binding site [chemical binding]; other site 446465000261 divalent metal binding site [ion binding]; other site 446465000262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446465000263 dimer interface [polypeptide binding]; other site 446465000264 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465000265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465000266 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465000267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000268 dimer interface [polypeptide binding]; other site 446465000269 conserved gate region; other site 446465000270 putative PBP binding loops; other site 446465000271 ABC-ATPase subunit interface; other site 446465000272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000273 dimer interface [polypeptide binding]; other site 446465000274 conserved gate region; other site 446465000275 putative PBP binding loops; other site 446465000276 ABC-ATPase subunit interface; other site 446465000277 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 446465000278 substrate binding site [chemical binding]; other site 446465000279 ATP binding site [chemical binding]; other site 446465000280 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 446465000281 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 446465000282 putative hydrophobic ligand binding site [chemical binding]; other site 446465000283 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465000284 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 446465000285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465000286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465000287 S-adenosylmethionine binding site [chemical binding]; other site 446465000288 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 446465000289 Sodium:solute symporter family; Region: SSF; cl00456 446465000290 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446465000291 nucleoside/Zn binding site; other site 446465000292 dimer interface [polypeptide binding]; other site 446465000293 catalytic motif [active] 446465000294 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446465000295 TM-ABC transporter signature motif; other site 446465000296 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446465000297 TM-ABC transporter signature motif; other site 446465000298 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446465000299 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 446465000300 Walker A/P-loop; other site 446465000301 ATP binding site [chemical binding]; other site 446465000302 Q-loop/lid; other site 446465000303 ABC transporter signature motif; other site 446465000304 Walker B; other site 446465000305 D-loop; other site 446465000306 H-loop/switch region; other site 446465000307 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 446465000308 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465000309 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 446465000310 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446465000311 Walker A/P-loop; other site 446465000312 ATP binding site [chemical binding]; other site 446465000313 Q-loop/lid; other site 446465000314 ABC transporter signature motif; other site 446465000315 Walker B; other site 446465000316 D-loop; other site 446465000317 H-loop/switch region; other site 446465000318 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 446465000319 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000320 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465000321 DNA binding site [nucleotide binding] 446465000322 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446465000323 ligand binding site [chemical binding]; other site 446465000324 dimerization interface (open form) [polypeptide binding]; other site 446465000325 dimerization interface (closed form) [polypeptide binding]; other site 446465000326 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 446465000327 Predicted membrane protein [Function unknown]; Region: COG1470 446465000328 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 446465000329 active site 446465000330 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 446465000331 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 446465000332 active site 446465000333 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465000334 Sulfatase; Region: Sulfatase; cl10460 446465000335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465000336 active site 446465000337 catalytic tetrad [active] 446465000338 Sulfatase; Region: Sulfatase; cl10460 446465000339 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465000340 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 446465000341 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465000342 catalytic core [active] 446465000343 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 446465000344 dimer interface [polypeptide binding]; other site 446465000345 putative metal binding site [ion binding]; other site 446465000346 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446465000347 Dak1 domain; Region: Dak1; pfam02733 446465000348 DAK2 domain; Region: Dak2; cl03685 446465000349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000351 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465000352 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000354 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465000355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465000356 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000358 dimer interface [polypeptide binding]; other site 446465000359 conserved gate region; other site 446465000360 putative PBP binding loops; other site 446465000361 ABC-ATPase subunit interface; other site 446465000362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465000363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465000364 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465000365 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465000366 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446465000367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465000368 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465000369 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446465000370 substrate binding site [chemical binding]; other site 446465000371 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465000372 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000374 dimer interface [polypeptide binding]; other site 446465000375 conserved gate region; other site 446465000376 putative PBP binding loops; other site 446465000377 ABC-ATPase subunit interface; other site 446465000378 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465000379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000380 dimer interface [polypeptide binding]; other site 446465000381 conserved gate region; other site 446465000382 putative PBP binding loops; other site 446465000383 ABC-ATPase subunit interface; other site 446465000384 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465000385 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465000386 Walker A/P-loop; other site 446465000387 ATP binding site [chemical binding]; other site 446465000388 Q-loop/lid; other site 446465000389 ABC transporter signature motif; other site 446465000390 Walker B; other site 446465000391 D-loop; other site 446465000392 H-loop/switch region; other site 446465000393 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465000394 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465000395 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465000396 Walker A/P-loop; other site 446465000397 ATP binding site [chemical binding]; other site 446465000398 Q-loop/lid; other site 446465000399 ABC transporter signature motif; other site 446465000400 Walker B; other site 446465000401 D-loop; other site 446465000402 H-loop/switch region; other site 446465000403 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 446465000404 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446465000405 domain; Region: Glyco_hydro_2; pfam00703 446465000406 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 446465000407 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465000408 dimerization interface [polypeptide binding]; other site 446465000409 ligand binding site [chemical binding]; other site 446465000410 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 446465000411 Predicted permease [General function prediction only]; Region: COG2985 446465000412 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 446465000413 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 446465000414 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465000415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465000416 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465000417 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 446465000418 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion...; Region: enolase_like; cl14814 446465000419 metal binding site [ion binding]; metal-binding site 446465000420 substrate binding pocket [chemical binding]; other site 446465000421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465000422 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446465000423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465000424 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446465000425 substrate binding site [chemical binding]; other site 446465000426 ATP binding site [chemical binding]; other site 446465000427 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446465000428 Entner-Doudoroff aldolase; Region: eda; TIGR01182 446465000429 active site 446465000430 intersubunit interface [polypeptide binding]; other site 446465000431 catalytic residue [active] 446465000432 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 446465000433 MgtE intracellular N domain; Region: MgtE_N; cl15244 446465000434 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446465000435 Divalent cation transporter; Region: MgtE; cl00786 446465000436 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465000438 DNA binding site [nucleotide binding] 446465000439 domain linker motif; other site 446465000440 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465000441 dimerization interface [polypeptide binding]; other site 446465000442 ligand binding site [chemical binding]; other site 446465000443 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465000444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465000445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000446 dimer interface [polypeptide binding]; other site 446465000447 conserved gate region; other site 446465000448 putative PBP binding loops; other site 446465000449 ABC-ATPase subunit interface; other site 446465000450 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000452 dimer interface [polypeptide binding]; other site 446465000453 conserved gate region; other site 446465000454 putative PBP binding loops; other site 446465000455 ABC-ATPase subunit interface; other site 446465000456 putative alpha-glucosidase; Provisional; Region: PRK10658 446465000457 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 446465000458 active site 446465000459 homotrimer interface [polypeptide binding]; other site 446465000460 catalytic site [active] 446465000461 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 446465000462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000464 dimer interface [polypeptide binding]; other site 446465000465 conserved gate region; other site 446465000466 putative PBP binding loops; other site 446465000467 ABC-ATPase subunit interface; other site 446465000468 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446465000469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000470 dimer interface [polypeptide binding]; other site 446465000471 conserved gate region; other site 446465000472 putative PBP binding loops; other site 446465000473 ABC-ATPase subunit interface; other site 446465000474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465000475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465000476 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000478 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465000479 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000481 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446465000482 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000484 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465000485 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465000486 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 446465000487 CARDB; Region: CARDB; pfam07705 446465000488 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446465000489 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465000490 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465000491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000492 dimer interface [polypeptide binding]; other site 446465000493 conserved gate region; other site 446465000494 putative PBP binding loops; other site 446465000495 ABC-ATPase subunit interface; other site 446465000496 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000498 dimer interface [polypeptide binding]; other site 446465000499 conserved gate region; other site 446465000500 ABC-ATPase subunit interface; other site 446465000501 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 446465000502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465000504 DNA binding site [nucleotide binding] 446465000505 domain linker motif; other site 446465000506 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465000507 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465000508 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 446465000509 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 446465000510 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465000511 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 446465000512 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 446465000513 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 446465000514 ATP binding site [chemical binding]; other site 446465000515 substrate interface [chemical binding]; other site 446465000516 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446465000517 active site residue [active] 446465000518 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 446465000519 ThiS interaction site; other site 446465000520 putative active site [active] 446465000521 tetramer interface [polypeptide binding]; other site 446465000522 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 446465000523 thiS-thiF/thiG interaction site; other site 446465000524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465000525 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 446465000526 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465000527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000528 NAD(P) binding site [chemical binding]; other site 446465000529 active site 446465000530 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 446465000531 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446465000532 active site 446465000533 non-prolyl cis peptide bond; other site 446465000534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465000536 DNA binding site [nucleotide binding] 446465000537 domain linker motif; other site 446465000538 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465000539 dimerization interface [polypeptide binding]; other site 446465000540 ligand binding site [chemical binding]; other site 446465000541 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465000542 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465000543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000544 dimer interface [polypeptide binding]; other site 446465000545 conserved gate region; other site 446465000546 putative PBP binding loops; other site 446465000547 ABC-ATPase subunit interface; other site 446465000548 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000550 dimer interface [polypeptide binding]; other site 446465000551 conserved gate region; other site 446465000552 putative PBP binding loops; other site 446465000553 ABC-ATPase subunit interface; other site 446465000554 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 446465000555 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 446465000556 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 446465000557 Ca binding site [ion binding]; other site 446465000558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000560 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465000561 Sodium:solute symporter family; Region: SSF; cl00456 446465000562 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465000563 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000564 active site 446465000565 catalytic tetrad [active] 446465000566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465000567 putative substrate translocation pore; other site 446465000568 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 446465000569 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 446465000570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465000571 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465000572 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465000573 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000575 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465000576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000578 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465000579 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 446465000580 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 446465000581 putative active site [active] 446465000582 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465000583 nudix motif; other site 446465000584 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465000585 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 446465000586 amidohydrolase; Region: amidohydrolases; TIGR01891 446465000587 metal binding site [ion binding]; metal-binding site 446465000588 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 446465000589 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 446465000590 putative ADP-binding pocket [chemical binding]; other site 446465000591 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446465000592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465000593 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465000594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465000595 Walker A/P-loop; other site 446465000596 ATP binding site [chemical binding]; other site 446465000597 Q-loop/lid; other site 446465000598 ABC transporter signature motif; other site 446465000599 Walker B; other site 446465000600 D-loop; other site 446465000601 H-loop/switch region; other site 446465000602 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465000603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000604 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 446465000605 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446465000606 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446465000607 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446465000608 Predicted membrane protein [Function unknown]; Region: COG1511 446465000609 Predicted membrane protein [Function unknown]; Region: COG1511 446465000610 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 446465000611 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446465000612 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465000613 active site 446465000614 HIGH motif; other site 446465000615 nucleotide binding site [chemical binding]; other site 446465000616 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465000617 active site 446465000618 KMSKS motif; other site 446465000619 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465000620 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446465000621 active site 446465000622 Rhomboid family; Region: Rhomboid; cl11446 446465000623 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 446465000624 putative substrate binding pocket [chemical binding]; other site 446465000625 AC domain interface; other site 446465000626 catalytic triad [active] 446465000627 AB domain interface; other site 446465000628 interchain disulfide; other site 446465000629 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465000630 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465000631 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465000632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465000633 Walker A/P-loop; other site 446465000634 ATP binding site [chemical binding]; other site 446465000635 Q-loop/lid; other site 446465000636 ABC transporter signature motif; other site 446465000637 Walker B; other site 446465000638 D-loop; other site 446465000639 H-loop/switch region; other site 446465000640 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465000641 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465000642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465000643 Walker A/P-loop; other site 446465000644 ATP binding site [chemical binding]; other site 446465000645 Q-loop/lid; other site 446465000646 ABC transporter signature motif; other site 446465000647 Walker B; other site 446465000648 D-loop; other site 446465000649 H-loop/switch region; other site 446465000650 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446465000651 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465000652 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465000653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446465000654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465000655 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446465000656 putative dimerization interface [polypeptide binding]; other site 446465000657 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465000658 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465000659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 446465000660 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446465000661 substrate binding pocket [chemical binding]; other site 446465000662 membrane-bound complex binding site; other site 446465000663 hinge residues; other site 446465000664 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465000665 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 446465000666 Walker A/P-loop; other site 446465000667 ATP binding site [chemical binding]; other site 446465000668 Q-loop/lid; other site 446465000669 ABC transporter signature motif; other site 446465000670 Walker B; other site 446465000671 D-loop; other site 446465000672 H-loop/switch region; other site 446465000673 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465000674 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446465000675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000676 dimer interface [polypeptide binding]; other site 446465000677 conserved gate region; other site 446465000678 putative PBP binding loops; other site 446465000679 ABC-ATPase subunit interface; other site 446465000680 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446465000681 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446465000682 Sulfate transporter family; Region: Sulfate_transp; cl00967 446465000683 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446465000684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465000685 dimerization interface [polypeptide binding]; other site 446465000686 putative DNA binding site [nucleotide binding]; other site 446465000687 putative Zn2+ binding site [ion binding]; other site 446465000688 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465000689 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000690 active site 446465000691 catalytic tetrad [active] 446465000692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465000693 active site 446465000694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465000695 Staphylococcal nuclease homologues; Region: SNc; smart00318 446465000696 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 446465000697 Catalytic site; other site 446465000698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465000699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465000700 active site 446465000701 phosphorylation site [posttranslational modification] 446465000702 intermolecular recognition site; other site 446465000703 dimerization interface [polypeptide binding]; other site 446465000704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 446465000705 DNA binding residues [nucleotide binding] 446465000706 dimerization interface [polypeptide binding]; other site 446465000707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465000708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465000709 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 446465000710 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446465000711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446465000712 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 446465000713 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465000714 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465000715 Walker A/P-loop; other site 446465000716 ATP binding site [chemical binding]; other site 446465000717 Q-loop/lid; other site 446465000718 ABC transporter signature motif; other site 446465000719 Walker B; other site 446465000720 D-loop; other site 446465000721 H-loop/switch region; other site 446465000722 Beta-lactamase; Region: Beta-lactamase; cl01009 446465000723 Domain of unknown function DUF21; Region: DUF21; pfam01595 446465000724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446465000725 Transporter associated domain; Region: CorC_HlyC; pfam03471 446465000726 pyruvate dehydrogenase; Provisional; Region: PRK06546 446465000727 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 446465000728 PYR/PP interface [polypeptide binding]; other site 446465000729 tetramer interface [polypeptide binding]; other site 446465000730 dimer interface [polypeptide binding]; other site 446465000731 TPP binding site [chemical binding]; other site 446465000732 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446465000733 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 446465000734 TPP-binding site [chemical binding]; other site 446465000735 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 446465000736 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 446465000737 Methylamine utilisation protein MauE; Region: MauE; pfam07291 446465000738 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 446465000739 NAD(P) binding site [chemical binding]; other site 446465000740 catalytic residues [active] 446465000741 Peptidase family M48; Region: Peptidase_M48; cl12018 446465000742 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465000743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465000744 putative substrate translocation pore; other site 446465000745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465000746 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465000747 putative substrate translocation pore; other site 446465000748 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 446465000749 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465000750 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 446465000751 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446465000752 Urb2/Npa2 family; Region: Urb2; pfam10441 446465000753 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446465000754 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 446465000755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000756 NAD(P) binding site [chemical binding]; other site 446465000757 Bacterial sugar transferase; Region: Bac_transf; cl00939 446465000758 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465000759 active site 446465000760 nucleotide binding site [chemical binding]; other site 446465000761 HIGH motif; other site 446465000762 KMSKS motif; other site 446465000763 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 446465000764 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 446465000765 FAD binding site [chemical binding]; other site 446465000766 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 446465000767 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 446465000768 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 446465000769 substrate binding site [chemical binding]; other site 446465000770 THF binding site; other site 446465000771 zinc-binding site [ion binding]; other site 446465000772 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446465000773 synthetase active site [active] 446465000774 NTP binding site [chemical binding]; other site 446465000775 metal binding site [ion binding]; metal-binding site 446465000776 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 446465000777 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 446465000778 substrate binding site [chemical binding]; other site 446465000779 tetramer interface [polypeptide binding]; other site 446465000780 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 446465000781 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 446465000782 NAD binding site [chemical binding]; other site 446465000783 substrate binding site [chemical binding]; other site 446465000784 homodimer interface [polypeptide binding]; other site 446465000785 active site 446465000786 Cupin domain; Region: Cupin_2; cl09118 446465000787 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 446465000788 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 446465000789 NADP binding site [chemical binding]; other site 446465000790 active site 446465000791 putative substrate binding site [chemical binding]; other site 446465000792 histidinol-phosphatase; Provisional; Region: PRK05588 446465000793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465000794 ABC transporter signature motif; other site 446465000795 Walker B; other site 446465000796 D-loop; other site 446465000797 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 446465000798 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 446465000799 NAD(P) binding site [chemical binding]; other site 446465000800 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 446465000801 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 446465000802 substrate-cofactor binding pocket; other site 446465000803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465000804 catalytic residue [active] 446465000805 putative efflux protein, MATE family; Region: matE; TIGR00797 446465000806 MatE; Region: MatE; pfam01554 446465000807 MatE; Region: MatE; pfam01554 446465000808 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 446465000809 Protein export membrane protein; Region: SecD_SecF; cl14618 446465000810 Protein export membrane protein; Region: SecD_SecF; cl14618 446465000811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465000812 active site 446465000813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465000814 active site 446465000815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465000816 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 446465000817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465000818 active site 446465000819 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446465000820 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446465000821 Active site [active] 446465000822 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 446465000823 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446465000824 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 446465000825 polycystin cation channel protein; Region: PCC; TIGR00864 446465000826 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 446465000827 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446465000828 Chain length determinant protein; Region: Wzz; cl01623 446465000829 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 446465000830 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 446465000831 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 446465000832 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446465000833 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 446465000834 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446465000835 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_6; cd04955 446465000836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446465000837 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 446465000838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 446465000839 dimer interface [polypeptide binding]; other site 446465000840 phosphorylation site [posttranslational modification] 446465000841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465000842 ATP binding site [chemical binding]; other site 446465000843 G-X-G motif; other site 446465000844 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465000845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465000846 active site 446465000847 phosphorylation site [posttranslational modification] 446465000848 intermolecular recognition site; other site 446465000849 dimerization interface [polypeptide binding]; other site 446465000850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 446465000851 DNA binding site [nucleotide binding] 446465000852 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 446465000853 dinuclear metal binding motif [ion binding]; other site 446465000854 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446465000855 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465000856 catalytic residue [active] 446465000857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465000858 DinB superfamily; Region: DinB_2; cl00986 446465000859 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 446465000860 putative metal binding residues [ion binding]; other site 446465000861 signature motif; other site 446465000862 dimer interface [polypeptide binding]; other site 446465000863 polyP binding site; other site 446465000864 active site 446465000865 substrate binding site [chemical binding]; other site 446465000866 acceptor-phosphate pocket; other site 446465000867 replicative DNA helicase; Region: DnaB; TIGR00665 446465000868 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446465000869 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 446465000870 Walker A motif; other site 446465000871 ATP binding site [chemical binding]; other site 446465000872 Walker B motif; other site 446465000873 DNA binding loops [nucleotide binding] 446465000874 Protein of unknown function, DUF485; Region: DUF485; cl01231 446465000875 Sodium:solute symporter family; Region: SSF; cl00456 446465000876 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446465000877 Protein of unknown function (DUF421); Region: DUF421; cl00990 446465000878 OsmC-like protein; Region: OsmC; cl00767 446465000879 IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 446465000880 Permease family; Region: Xan_ur_permease; pfam00860 446465000881 Sulfate transporter family; Region: Sulfate_transp; cl00967 446465000882 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 446465000883 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446465000884 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465000885 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465000886 active site 446465000887 ATP binding site [chemical binding]; other site 446465000888 substrate binding site [chemical binding]; other site 446465000889 activation loop (A-loop); other site 446465000890 Beta-lactamase; Region: Beta-lactamase; cl01009 446465000891 Uncharacterized conserved protein [Function unknown]; Region: COG4279 446465000892 SNF2 Helicase protein; Region: DUF3670; pfam12419 446465000893 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 446465000894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465000895 ATP binding site [chemical binding]; other site 446465000896 putative Mg++ binding site [ion binding]; other site 446465000897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465000898 nucleotide binding region [chemical binding]; other site 446465000899 ATP-binding site [chemical binding]; other site 446465000900 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 446465000901 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 446465000902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 446465000903 DNA binding site [nucleotide binding] 446465000904 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 446465000905 UreD urease accessory protein; Region: UreD; cl00530 446465000906 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 446465000907 urease subunit alpha; Reviewed; Region: ureC; PRK13206 446465000908 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 446465000909 subunit interactions [polypeptide binding]; other site 446465000910 active site 446465000911 flap region; other site 446465000912 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 446465000913 gamma-beta subunit interface [polypeptide binding]; other site 446465000914 alpha-beta subunit interface [polypeptide binding]; other site 446465000915 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 446465000916 alpha-gamma subunit interface [polypeptide binding]; other site 446465000917 beta-gamma subunit interface [polypeptide binding]; other site 446465000918 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465000919 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446465000920 nucleoside/Zn binding site; other site 446465000921 dimer interface [polypeptide binding]; other site 446465000922 catalytic motif [active] 446465000923 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446465000924 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 446465000925 Walker A/P-loop; other site 446465000926 ATP binding site [chemical binding]; other site 446465000927 Q-loop/lid; other site 446465000928 ABC transporter signature motif; other site 446465000929 Walker B; other site 446465000930 D-loop; other site 446465000931 H-loop/switch region; other site 446465000932 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446465000933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465000934 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 446465000935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465000936 Response regulator receiver domain; Region: Response_reg; pfam00072 446465000937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465000938 active site 446465000939 phosphorylation site [posttranslational modification] 446465000940 intermolecular recognition site; other site 446465000941 dimerization interface [polypeptide binding]; other site 446465000942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465000943 Histidine kinase; Region: HisKA_3; pfam07730 446465000944 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 446465000945 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465000946 Walker A/P-loop; other site 446465000947 ATP binding site [chemical binding]; other site 446465000948 Q-loop/lid; other site 446465000949 ABC transporter signature motif; other site 446465000950 Walker B; other site 446465000951 D-loop; other site 446465000952 H-loop/switch region; other site 446465000953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465000954 putative PBP binding loops; other site 446465000955 ABC-ATPase subunit interface; other site 446465000956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465000957 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465000958 classical (c) SDRs; Region: SDR_c; cd05233 446465000959 NAD(P) binding site [chemical binding]; other site 446465000960 active site 446465000961 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446465000962 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 446465000963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465000964 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 446465000965 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465000966 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465000967 Ligand Binding Site [chemical binding]; other site 446465000968 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446465000969 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446465000970 dimerization domain swap beta strand [polypeptide binding]; other site 446465000971 regulatory protein interface [polypeptide binding]; other site 446465000972 active site 446465000973 regulatory phosphorylation site [posttranslational modification]; other site 446465000974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465000975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465000976 hypothetical protein; Provisional; Region: PRK07906 446465000977 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446465000978 putative metal binding site [ion binding]; other site 446465000979 Ferritin-like domain; Region: Ferritin; pfam00210 446465000980 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446465000981 dimerization interface [polypeptide binding]; other site 446465000982 DPS ferroxidase diiron center [ion binding]; other site 446465000983 ion pore; other site 446465000984 Fe-S metabolism associated domain; Region: SufE; cl00951 446465000985 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446465000986 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 446465000987 active site residue [active] 446465000988 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446465000989 active site residue [active] 446465000990 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 446465000991 active site/substrate binding site [active] 446465000992 tetramer interface [polypeptide binding]; other site 446465000993 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465000994 hydrophobic ligand binding site; other site 446465000995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465000996 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 446465000997 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 446465000998 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 446465000999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465001000 ATP binding site [chemical binding]; other site 446465001001 putative Mg++ binding site [ion binding]; other site 446465001002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 446465001003 Helicase associated domain (HA2); Region: HA2; cl04503 446465001004 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 446465001005 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 446465001006 BCCT family transporter; Region: BCCT; cl00569 446465001007 Membrane transport protein; Region: Mem_trans; cl09117 446465001008 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 446465001009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465001010 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465001011 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465001012 Quinolinate synthetase A protein; Region: NadA; cl00420 446465001013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465001014 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 446465001015 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 446465001016 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 446465001017 dimerization interface [polypeptide binding]; other site 446465001018 active site 446465001019 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446465001020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465001021 catalytic residue [active] 446465001022 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 446465001023 Aminotransferase class IV; Region: Aminotran_4; pfam01063 446465001024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465001025 catalytic residue [active] 446465001026 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 446465001027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 446465001028 DNA binding residues [nucleotide binding] 446465001029 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 446465001030 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446465001031 active site 446465001032 phosphorylation site [posttranslational modification] 446465001033 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465001034 nudix motif; other site 446465001035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465001036 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465001037 active site 446465001038 catalytic tetrad [active] 446465001039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465001040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001041 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465001042 Beta-lactamase; Region: Beta-lactamase; cl01009 446465001043 NlpC/P60 family; Region: NLPC_P60; cl11438 446465001044 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 446465001045 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 446465001046 active site 446465001047 Protein of unknown function (DUF819); Region: DUF819; cl02317 446465001048 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 446465001049 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446465001050 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446465001051 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 446465001052 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 446465001053 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446465001054 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 446465001055 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446465001056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001057 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446465001058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001059 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001061 dimer interface [polypeptide binding]; other site 446465001062 conserved gate region; other site 446465001063 putative PBP binding loops; other site 446465001064 ABC-ATPase subunit interface; other site 446465001065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001067 DNA binding site [nucleotide binding] 446465001068 domain linker motif; other site 446465001069 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465001070 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 446465001071 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 446465001072 Sodium:solute symporter family; Region: SSF; cl00456 446465001073 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001076 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001078 dimer interface [polypeptide binding]; other site 446465001079 conserved gate region; other site 446465001080 putative PBP binding loops; other site 446465001081 ABC-ATPase subunit interface; other site 446465001082 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 446465001083 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 446465001084 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001086 dimer interface [polypeptide binding]; other site 446465001087 conserved gate region; other site 446465001088 putative PBP binding loops; other site 446465001089 ABC-ATPase subunit interface; other site 446465001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001091 dimer interface [polypeptide binding]; other site 446465001092 conserved gate region; other site 446465001093 putative PBP binding loops; other site 446465001094 ABC-ATPase subunit interface; other site 446465001095 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001096 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cd00172 446465001097 reactive center loop; other site 446465001098 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 446465001099 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001100 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001102 dimer interface [polypeptide binding]; other site 446465001103 conserved gate region; other site 446465001104 putative PBP binding loops; other site 446465001105 ABC-ATPase subunit interface; other site 446465001106 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465001107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001108 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465001109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001110 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465001111 hypothetical protein; Provisional; Region: PRK06184 446465001112 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465001113 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 446465001114 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 446465001115 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446465001116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465001117 sequence-specific DNA binding site [nucleotide binding]; other site 446465001118 salt bridge; other site 446465001119 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446465001120 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446465001121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 446465001122 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 446465001123 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465001124 catalytic Zn binding site [ion binding]; other site 446465001125 NAD(P) binding site [chemical binding]; other site 446465001126 structural Zn binding site [ion binding]; other site 446465001127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 446465001128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465001129 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446465001130 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 446465001131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465001132 S-adenosylmethionine binding site [chemical binding]; other site 446465001133 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446465001134 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446465001135 Walker A/P-loop; other site 446465001136 ATP binding site [chemical binding]; other site 446465001137 Q-loop/lid; other site 446465001138 ABC transporter signature motif; other site 446465001139 Walker B; other site 446465001140 D-loop; other site 446465001141 H-loop/switch region; other site 446465001142 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 446465001143 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446465001144 intersubunit interface [polypeptide binding]; other site 446465001145 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 446465001146 ABC-ATPase subunit interface; other site 446465001147 dimer interface [polypeptide binding]; other site 446465001148 putative PBP binding regions; other site 446465001149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465001150 dimerization interface [polypeptide binding]; other site 446465001151 putative DNA binding site [nucleotide binding]; other site 446465001152 putative Zn2+ binding site [ion binding]; other site 446465001153 UbiA prenyltransferase family; Region: UbiA; cl00337 446465001154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465001155 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 446465001156 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446465001157 substrate binding pocket [chemical binding]; other site 446465001158 substrate-Mg2+ binding site; other site 446465001159 aspartate-rich region 1; other site 446465001160 aspartate-rich region 2; other site 446465001161 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446465001162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001163 NAD(P) binding site [chemical binding]; other site 446465001164 active site 446465001165 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446465001166 substrate binding pocket [chemical binding]; other site 446465001167 substrate-Mg2+ binding site; other site 446465001168 aspartate-rich region 1; other site 446465001169 aspartate-rich region 2; other site 446465001170 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and...; Region: IPP_Isomerase; cd02885 446465001171 active site 446465001172 metal binding site [ion binding]; metal-binding site 446465001173 nudix motif; other site 446465001174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465001175 FAD binding domain; Region: FAD_binding_3; pfam01494 446465001176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465001177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465001178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465001179 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 446465001180 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 446465001181 malonyl-CoA binding site [chemical binding]; other site 446465001182 dimer interface [polypeptide binding]; other site 446465001183 active site 446465001184 product binding site; other site 446465001185 ANTAR domain; Region: ANTAR; pfam03861 446465001186 Integrase core domain; Region: rve; cl01316 446465001187 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446465001188 homotrimer interaction site [polypeptide binding]; other site 446465001189 putative active site [active] 446465001190 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 446465001191 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465001192 active site 446465001193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465001194 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446465001195 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 446465001196 dimer interface [polypeptide binding]; other site 446465001197 active site 446465001198 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465001199 substrate binding site [chemical binding]; other site 446465001200 catalytic residue [active] 446465001201 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446465001202 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 446465001203 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446465001204 putative NAD(P) binding site [chemical binding]; other site 446465001205 Proline racemase; Region: Pro_racemase; pfam05544 446465001206 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 446465001207 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 446465001208 enoyl-CoA hydratase; Provisional; Region: PRK07657 446465001209 substrate binding site [chemical binding]; other site 446465001210 oxyanion hole (OAH) forming residues; other site 446465001211 trimer interface [polypeptide binding]; other site 446465001212 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446465001213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001214 NAD(P) binding site [chemical binding]; other site 446465001215 active site 446465001216 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 446465001217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465001218 active site 446465001219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465001220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465001221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465001222 putative substrate translocation pore; other site 446465001223 putative inner membrane protein; Provisional; Region: PRK11099 446465001224 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 446465001225 CPxP motif; other site 446465001226 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446465001227 DNA binding site [nucleotide binding] 446465001228 active site 446465001229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465001230 classical (c) SDRs; Region: SDR_c; cd05233 446465001231 NAD(P) binding site [chemical binding]; other site 446465001232 active site 446465001233 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465001234 Sulfatase; Region: Sulfatase; cl10460 446465001235 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446465001236 FAD binding domain; Region: FAD_binding_4; pfam01565 446465001237 Berberine and berberine like; Region: BBE; pfam08031 446465001238 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 446465001239 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446465001240 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 446465001241 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 446465001242 putative ligand binding site [chemical binding]; other site 446465001243 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446465001244 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465001245 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 446465001246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001247 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446465001248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465001249 Walker A/P-loop; other site 446465001250 ATP binding site [chemical binding]; other site 446465001251 Q-loop/lid; other site 446465001252 ABC transporter signature motif; other site 446465001253 Walker B; other site 446465001254 D-loop; other site 446465001255 H-loop/switch region; other site 446465001256 TOBE domain; Region: TOBE_2; cl01440 446465001257 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 446465001258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001259 dimer interface [polypeptide binding]; other site 446465001260 conserved gate region; other site 446465001261 putative PBP binding loops; other site 446465001262 ABC-ATPase subunit interface; other site 446465001263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001264 dimer interface [polypeptide binding]; other site 446465001265 conserved gate region; other site 446465001266 putative PBP binding loops; other site 446465001267 ABC-ATPase subunit interface; other site 446465001268 argininosuccinate lyase; Provisional; Region: PRK00855 446465001269 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446465001270 tetramer interface [polypeptide binding]; other site 446465001271 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 446465001272 substrate binding site [chemical binding]; other site 446465001273 ATP binding site [chemical binding]; other site 446465001274 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446465001275 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 446465001276 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 446465001277 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446465001278 active site 446465001279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001280 dimer interface [polypeptide binding]; other site 446465001281 conserved gate region; other site 446465001282 putative PBP binding loops; other site 446465001283 ABC-ATPase subunit interface; other site 446465001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001285 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 446465001286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001287 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001288 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001289 DNA binding site [nucleotide binding] 446465001290 domain linker motif; other site 446465001291 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465001292 dimerization interface [polypeptide binding]; other site 446465001293 ligand binding site [chemical binding]; other site 446465001294 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465001295 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465001296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465001297 ATP binding site [chemical binding]; other site 446465001298 putative Mg++ binding site [ion binding]; other site 446465001299 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 446465001300 Cupin domain; Region: Cupin_2; cl09118 446465001301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465001302 alpha-galactosidase; Provisional; Region: PRK15076 446465001303 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 446465001304 NAD(P) binding site [chemical binding]; other site 446465001305 LDH/MDH dimer interface [polypeptide binding]; other site 446465001306 substrate binding site [chemical binding]; other site 446465001307 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446465001308 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465001309 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465001310 active site 446465001311 metal binding site [ion binding]; metal-binding site 446465001312 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 446465001313 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 446465001314 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465001315 Sulfatase; Region: Sulfatase; cl10460 446465001316 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 446465001317 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 446465001318 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 446465001319 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 446465001320 hypothetical protein; Provisional; Region: PRK02947 446465001321 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 446465001322 putative active site [active] 446465001323 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 446465001324 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446465001325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465001326 DNA-binding site [nucleotide binding]; DNA binding site 446465001327 UTRA domain; Region: UTRA; cl06649 446465001328 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001331 dimer interface [polypeptide binding]; other site 446465001332 conserved gate region; other site 446465001333 putative PBP binding loops; other site 446465001334 ABC-ATPase subunit interface; other site 446465001335 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001337 dimer interface [polypeptide binding]; other site 446465001338 conserved gate region; other site 446465001339 putative PBP binding loops; other site 446465001340 ABC-ATPase subunit interface; other site 446465001341 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 446465001342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 446465001343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 446465001344 D-lactate dehydrogenase; Provisional; Region: PRK11183 446465001345 FAD binding domain; Region: FAD_binding_4; pfam01565 446465001346 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 446465001347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001348 NAD(P) binding site [chemical binding]; other site 446465001349 active site 446465001350 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 446465001351 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 446465001352 active site 446465001353 Peptidase family C69; Region: Peptidase_C69; cl01920 446465001354 Predicted membrane protein [Function unknown]; Region: COG4129 446465001355 Uncharacterized conserved protein [Function unknown]; Region: COG4127 446465001356 Restriction endonuclease; Region: Mrr_cat; cl00747 446465001357 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446465001358 QueT transporter; Region: QueT; cl01932 446465001359 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 446465001360 putative homodimer interface [polypeptide binding]; other site 446465001361 putative active site [active] 446465001362 catalytic site [active] 446465001363 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465001364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 446465001365 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 446465001366 Restriction endonuclease; Region: Mrr_cat; cl00747 446465001367 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 446465001368 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446465001369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465001370 ATP binding site [chemical binding]; other site 446465001371 putative Mg++ binding site [ion binding]; other site 446465001372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465001373 nucleotide binding region [chemical binding]; other site 446465001374 ATP-binding site [chemical binding]; other site 446465001375 MAEBL; Provisional; Region: PTZ00121 446465001376 FRG domain; Region: FRG; pfam08867 446465001377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465001378 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465001379 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 446465001380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465001381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465001382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465001383 Restriction endonuclease [Defense mechanisms]; Region: COG3587 446465001384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465001385 ATP binding site [chemical binding]; other site 446465001386 putative Mg++ binding site [ion binding]; other site 446465001387 potential frameshift: common BLAST hit: gi|86741627|ref|YP_482027.1| protein of unknown function DUF1524 RloF 446465001388 Protein of unknown function DUF262; Region: DUF262; cl14890 446465001389 Protein of unknown function DUF262; Region: DUF262; cl14890 446465001390 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 446465001391 MgtC family; Region: MgtC; cl12207 446465001392 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 446465001393 hypothetical protein; Reviewed; Region: PRK09588 446465001394 Uncharacterized conserved protein [Function unknown]; Region: COG4127 446465001395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465001396 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 446465001397 Walker A motif; other site 446465001398 ATP binding site [chemical binding]; other site 446465001399 Walker B motif; other site 446465001400 arginine finger; other site 446465001401 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 446465001402 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465001403 active site 446465001404 ATP binding site [chemical binding]; other site 446465001405 substrate binding site [chemical binding]; other site 446465001406 activation loop (A-loop); other site 446465001407 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446465001408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446465001409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 446465001410 DNA binding residues [nucleotide binding] 446465001411 Fic family protein [Function unknown]; Region: COG3177 446465001412 Fic/DOC family; Region: Fic; cl00960 446465001413 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 446465001414 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 446465001415 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 446465001416 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465001417 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465001418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001420 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465001421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001422 putative PBP binding loops; other site 446465001423 ABC-ATPase subunit interface; other site 446465001424 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465001425 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465001426 Walker A/P-loop; other site 446465001427 ATP binding site [chemical binding]; other site 446465001428 Q-loop/lid; other site 446465001429 ABC transporter signature motif; other site 446465001430 Walker B; other site 446465001431 D-loop; other site 446465001432 H-loop/switch region; other site 446465001433 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465001434 Walker A/P-loop; other site 446465001435 ATP binding site [chemical binding]; other site 446465001436 Q-loop/lid; other site 446465001437 ABC transporter signature motif; other site 446465001438 Walker B; other site 446465001439 D-loop; other site 446465001440 H-loop/switch region; other site 446465001441 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 446465001442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465001443 potential frameshift: common BLAST hit: gi|152966696|ref|YP_001362480.1| uncharacterized peroxidase-related enzyme 446465001444 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446465001445 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446465001446 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 446465001447 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 446465001448 FOG: WD40-like repeat [Function unknown]; Region: COG1520 446465001449 Trp docking motif; other site 446465001450 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 446465001451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001452 NAD(P) binding site [chemical binding]; other site 446465001453 active site 446465001454 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465001455 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 446465001456 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465001457 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 446465001458 Ferritin-like domain; Region: Ferritin; pfam00210 446465001459 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446465001460 dimerization interface [polypeptide binding]; other site 446465001461 DPS ferroxidase diiron center [ion binding]; other site 446465001462 ion pore; other site 446465001463 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465001464 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465001465 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948 446465001466 active site 446465001467 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948 446465001468 active site 446465001469 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 446465001470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001473 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001475 dimer interface [polypeptide binding]; other site 446465001476 conserved gate region; other site 446465001477 putative PBP binding loops; other site 446465001478 ABC-ATPase subunit interface; other site 446465001479 Helix-turn-helix domain; Region: HTH_18; pfam12833 446465001480 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 446465001481 CsbD-like; Region: CsbD; cl01272 446465001482 aconitate hydratase; Validated; Region: PRK07229 446465001483 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446465001484 substrate binding site [chemical binding]; other site 446465001485 ligand binding site [chemical binding]; other site 446465001486 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 446465001487 substrate binding site [chemical binding]; other site 446465001488 NeuB family; Region: NeuB; cl00496 446465001489 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 446465001490 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 446465001491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465001492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465001493 putative substrate translocation pore; other site 446465001494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465001495 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465001496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465001497 active site 446465001498 phosphorylation site [posttranslational modification] 446465001499 intermolecular recognition site; other site 446465001500 dimerization interface [polypeptide binding]; other site 446465001501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 446465001502 DNA binding residues [nucleotide binding] 446465001503 dimerization interface [polypeptide binding]; other site 446465001504 Histidine kinase; Region: HisKA_3; pfam07730 446465001505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465001506 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 446465001507 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001508 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001509 DNA binding site [nucleotide binding] 446465001510 domain linker motif; other site 446465001511 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465001512 ligand binding site [chemical binding]; other site 446465001513 dimerization interface [polypeptide binding]; other site 446465001514 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446465001515 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 446465001516 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 446465001517 ATP binding site [chemical binding]; other site 446465001518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465001519 non-specific DNA binding site [nucleotide binding]; other site 446465001520 salt bridge; other site 446465001521 sequence-specific DNA binding site [nucleotide binding]; other site 446465001522 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446465001523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465001524 Coenzyme A binding pocket [chemical binding]; other site 446465001525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001526 NAD(P) binding site [chemical binding]; other site 446465001527 active site 446465001528 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465001529 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465001530 active site 446465001531 catalytic tetrad [active] 446465001532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465001533 Active site [active] 446465001534 UvrD/REP helicase; Region: UvrD-helicase; cl14126 446465001535 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 446465001536 UvrD/REP helicase; Region: UvrD-helicase; cl14126 446465001537 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446465001538 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446465001539 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446465001540 Glutaminase; Region: Glutaminase; cl00907 446465001541 Glutaminase; Region: Glutaminase; cl00907 446465001542 Sulfatase; Region: Sulfatase; cl10460 446465001543 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465001544 HflK protein; Region: hflK; TIGR01933 446465001545 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 446465001546 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 446465001547 catalytic residues [active] 446465001548 dimer interface [polypeptide binding]; other site 446465001549 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 446465001550 substrate binding site [chemical binding]; other site 446465001551 ATP binding site [chemical binding]; other site 446465001552 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446465001553 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 446465001554 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446465001555 nucleoside/Zn binding site; other site 446465001556 dimer interface [polypeptide binding]; other site 446465001557 catalytic motif [active] 446465001558 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446465001559 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 446465001560 active site 446465001561 FMN binding site [chemical binding]; other site 446465001562 2,4-decadienoyl-CoA binding site; other site 446465001563 catalytic residue [active] 446465001564 4Fe-4S cluster binding site [ion binding]; other site 446465001565 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 446465001566 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446465001567 Isochorismatase family; Region: Isochorismatase; pfam00857 446465001568 catalytic triad [active] 446465001569 conserved cis-peptide bond; other site 446465001570 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 446465001571 active site 446465001572 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 446465001573 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 446465001574 DNA binding residues [nucleotide binding] 446465001575 drug binding residues [chemical binding]; other site 446465001576 dimer interface [polypeptide binding]; other site 446465001577 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446465001578 Active site [active] 446465001579 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446465001580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465001581 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 446465001582 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465001583 hydrophobic ligand binding site; other site 446465001584 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 446465001585 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446465001586 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446465001587 Walker A/P-loop; other site 446465001588 ATP binding site [chemical binding]; other site 446465001589 Q-loop/lid; other site 446465001590 ABC transporter signature motif; other site 446465001591 Walker B; other site 446465001592 D-loop; other site 446465001593 H-loop/switch region; other site 446465001594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465001595 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465001596 ATP binding site [chemical binding]; other site 446465001597 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446465001598 Predicted membrane protein [Function unknown]; Region: COG4270 446465001599 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001602 dimer interface [polypeptide binding]; other site 446465001603 conserved gate region; other site 446465001604 putative PBP binding loops; other site 446465001605 ABC-ATPase subunit interface; other site 446465001606 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001608 dimer interface [polypeptide binding]; other site 446465001609 conserved gate region; other site 446465001610 putative PBP binding loops; other site 446465001611 ABC-ATPase subunit interface; other site 446465001612 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465001613 active site 446465001614 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446465001615 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446465001616 Walker A/P-loop; other site 446465001617 ATP binding site [chemical binding]; other site 446465001618 Q-loop/lid; other site 446465001619 ABC transporter signature motif; other site 446465001620 Walker B; other site 446465001621 D-loop; other site 446465001622 H-loop/switch region; other site 446465001623 Histidine kinase; Region: HisKA_3; pfam07730 446465001624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465001625 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465001626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465001627 active site 446465001628 phosphorylation site [posttranslational modification] 446465001629 intermolecular recognition site; other site 446465001630 dimerization interface [polypeptide binding]; other site 446465001631 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 446465001632 DNA binding residues [nucleotide binding] 446465001633 dimerization interface [polypeptide binding]; other site 446465001634 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465001635 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465001636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465001637 Walker A/P-loop; other site 446465001638 ATP binding site [chemical binding]; other site 446465001639 Q-loop/lid; other site 446465001640 ABC transporter signature motif; other site 446465001641 Walker B; other site 446465001642 D-loop; other site 446465001643 H-loop/switch region; other site 446465001644 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 446465001645 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446465001646 Walker A/P-loop; other site 446465001647 ATP binding site [chemical binding]; other site 446465001648 Q-loop/lid; other site 446465001649 ABC transporter signature motif; other site 446465001650 Walker B; other site 446465001651 D-loop; other site 446465001652 H-loop/switch region; other site 446465001653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465001654 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 446465001655 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 446465001656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465001657 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446465001658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001659 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465001660 putative metal binding site [ion binding]; other site 446465001661 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446465001662 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 446465001663 active site residue [active] 446465001664 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446465001665 active site residue [active] 446465001666 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 446465001667 Predicted membrane protein [Function unknown]; Region: COG4425 446465001668 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446465001669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001670 BCCT family transporter; Region: BCCT; cl00569 446465001671 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 446465001672 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465001673 arginine-tRNA ligase; Region: PLN02286 446465001674 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 446465001675 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465001676 active site 446465001677 HIGH motif; other site 446465001678 nucleotide binding site [chemical binding]; other site 446465001679 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 446465001680 KMSK motif region; other site 446465001681 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446465001682 tRNA binding surface [nucleotide binding]; other site 446465001683 anticodon binding site; other site 446465001684 hypothetical protein; Provisional; Region: PRK11770 446465001685 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446465001686 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446465001687 Flavin Reductases; Region: FlaRed; cl00801 446465001688 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465001689 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465001690 substrate binding pocket [chemical binding]; other site 446465001691 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465001692 Sulfate transporter family; Region: Sulfate_transp; cl00967 446465001693 ornithine cyclodeaminase; Validated; Region: PRK07589 446465001694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001695 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 446465001696 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 446465001697 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 446465001698 Glutaminase; Region: Glutaminase; cl00907 446465001699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465001700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465001701 Coenzyme A binding pocket [chemical binding]; other site 446465001702 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465001703 active site 446465001704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465001705 DNA-binding site [nucleotide binding]; DNA binding site 446465001706 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 446465001707 active site 446465001708 prephenate dehydratase; Provisional; Region: PRK11898 446465001709 Prephenate dehydratase; Region: PDT; pfam00800 446465001710 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 446465001711 putative L-Phe binding site [chemical binding]; other site 446465001712 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 446465001713 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465001714 Ligand Binding Site [chemical binding]; other site 446465001715 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465001716 Ligand Binding Site [chemical binding]; other site 446465001717 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446465001718 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 446465001719 seryl-tRNA synthetase; Provisional; Region: PRK05431 446465001720 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 446465001721 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 446465001722 dimer interface [polypeptide binding]; other site 446465001723 active site 446465001724 motif 1; other site 446465001725 motif 2; other site 446465001726 motif 3; other site 446465001727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465001728 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446465001729 active site 446465001730 motif I; other site 446465001731 motif II; other site 446465001732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465001733 Enoylreductase; Region: PKS_ER; smart00829 446465001734 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 446465001735 NAD(P) binding site [chemical binding]; other site 446465001736 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 446465001737 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 446465001738 NADP binding site [chemical binding]; other site 446465001739 dimer interface [polypeptide binding]; other site 446465001740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 446465001741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465001742 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465001743 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465001744 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 446465001745 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 446465001746 nucleotide binding site/active site [active] 446465001747 HIT family signature motif; other site 446465001748 catalytic residue [active] 446465001749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 446465001750 Predicted transcriptional regulators [Transcription]; Region: COG1725 446465001751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465001752 DNA-binding site [nucleotide binding]; DNA binding site 446465001753 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446465001754 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446465001755 Walker A/P-loop; other site 446465001756 ATP binding site [chemical binding]; other site 446465001757 Q-loop/lid; other site 446465001758 ABC transporter signature motif; other site 446465001759 Walker B; other site 446465001760 D-loop; other site 446465001761 H-loop/switch region; other site 446465001762 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446465001763 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 446465001764 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 446465001765 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 446465001766 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 446465001767 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446465001768 dimerization domain swap beta strand [polypeptide binding]; other site 446465001769 regulatory protein interface [polypeptide binding]; other site 446465001770 active site 446465001771 regulatory phosphorylation site [posttranslational modification]; other site 446465001772 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 446465001773 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446465001774 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446465001775 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 446465001776 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 446465001777 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 446465001778 active site 446465001779 P-loop; other site 446465001780 phosphorylation site [posttranslational modification] 446465001781 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446465001782 active site 446465001783 phosphorylation site [posttranslational modification] 446465001784 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446465001785 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 446465001786 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 446465001787 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 446465001788 putative DNA binding site [nucleotide binding]; other site 446465001789 putative homodimer interface [polypeptide binding]; other site 446465001790 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 446465001791 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: MtLigD_Pol_like; cd04863 446465001792 nucleotide binding site [chemical binding]; other site 446465001793 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 446465001794 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 446465001795 active site 446465001796 DNA binding site [nucleotide binding] 446465001797 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 446465001798 DNA binding site [nucleotide binding] 446465001799 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 446465001800 DNA-binding site [nucleotide binding]; DNA binding site 446465001801 RNA-binding motif; other site 446465001802 Protein of unknown function (DUF1222); Region: DUF1222; pfam06762 446465001803 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465001804 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 446465001805 putative NAD(P) binding site [chemical binding]; other site 446465001806 catalytic Zn binding site [ion binding]; other site 446465001807 structural Zn binding site [ion binding]; other site 446465001808 BioY family; Region: BioY; cl00560 446465001809 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446465001810 putative active site [active] 446465001811 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 446465001812 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001814 DNA binding site [nucleotide binding] 446465001815 domain linker motif; other site 446465001816 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465001817 ligand binding site [chemical binding]; other site 446465001818 dimerization interface [polypeptide binding]; other site 446465001819 Ion channel; Region: Ion_trans_2; cl11596 446465001820 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 446465001821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001822 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 446465001823 catalytic triad [active] 446465001824 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465001825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465001826 DNA-binding site [nucleotide binding]; DNA binding site 446465001827 FCD domain; Region: FCD; cl11656 446465001828 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 446465001829 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 446465001830 substrate binding pocket [chemical binding]; other site 446465001831 membrane-bound complex binding site; other site 446465001832 hinge residues; other site 446465001833 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446465001834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001835 dimer interface [polypeptide binding]; other site 446465001836 conserved gate region; other site 446465001837 putative PBP binding loops; other site 446465001838 ABC-ATPase subunit interface; other site 446465001839 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446465001840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465001841 dimer interface [polypeptide binding]; other site 446465001842 conserved gate region; other site 446465001843 putative PBP binding loops; other site 446465001844 ABC-ATPase subunit interface; other site 446465001845 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465001846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465001847 Walker A/P-loop; other site 446465001848 ATP binding site [chemical binding]; other site 446465001849 Q-loop/lid; other site 446465001850 ABC transporter signature motif; other site 446465001851 Walker B; other site 446465001852 D-loop; other site 446465001853 H-loop/switch region; other site 446465001854 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 446465001855 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 446465001856 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446465001857 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465001858 active site 446465001859 catalytic tetrad [active] 446465001860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465001861 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012 446465001862 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465001863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465001864 Coenzyme A binding pocket [chemical binding]; other site 446465001865 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446465001866 Active site [active] 446465001867 phosphoglucomutase; Validated; Region: PRK07564 446465001868 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 446465001869 active site 446465001870 substrate binding site [chemical binding]; other site 446465001871 metal binding site [ion binding]; metal-binding site 446465001872 Phosphate transporter family; Region: PHO4; cl00396 446465001873 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 446465001874 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446465001875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465001876 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465001877 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465001878 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001879 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465001880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465001883 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 446465001884 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 446465001885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465001886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465001887 homodimer interface [polypeptide binding]; other site 446465001888 catalytic residue [active] 446465001889 ferredoxin-NADP+ reductase; Region: PLN02852 446465001890 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446465001891 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 446465001892 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 446465001893 Domain of unknown function (DUF404); Region: DUF404; pfam04169 446465001894 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 446465001895 Protein of unknown function DUF124; Region: DUF124; cl00884 446465001896 Protein kinase domain; Region: Pkinase; pfam00069 446465001897 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465001898 active site 446465001899 ATP binding site [chemical binding]; other site 446465001900 substrate binding site [chemical binding]; other site 446465001901 activation loop (A-loop); other site 446465001902 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 446465001903 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 446465001904 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 446465001905 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446465001906 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446465001907 ring oligomerisation interface [polypeptide binding]; other site 446465001908 ATP/Mg binding site [chemical binding]; other site 446465001909 stacking interactions; other site 446465001910 hinge regions; other site 446465001911 Cobalt transport protein; Region: CbiQ; cl00463 446465001912 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465001913 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 446465001914 Walker A/P-loop; other site 446465001915 ATP binding site [chemical binding]; other site 446465001916 Q-loop/lid; other site 446465001917 ABC transporter signature motif; other site 446465001918 Walker B; other site 446465001919 D-loop; other site 446465001920 H-loop/switch region; other site 446465001921 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 446465001922 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 446465001923 Walker A/P-loop; other site 446465001924 ATP binding site [chemical binding]; other site 446465001925 Q-loop/lid; other site 446465001926 ABC transporter signature motif; other site 446465001927 Walker B; other site 446465001928 D-loop; other site 446465001929 H-loop/switch region; other site 446465001930 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 446465001931 Uncharacterized conserved protein [Function unknown]; Region: COG1912 446465001932 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 446465001933 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 446465001934 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 446465001935 DctM-like transporters; Region: DctM; pfam06808 446465001936 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 446465001937 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 446465001938 putative catalytic site [active] 446465001939 putative metal binding site [ion binding]; other site 446465001940 putative phosphate binding site [ion binding]; other site 446465001941 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465001942 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446465001943 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465001944 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446465001945 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 446465001946 nucleotide binding site/active site [active] 446465001947 HIT family signature motif; other site 446465001948 catalytic residue [active] 446465001949 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 446465001950 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 446465001951 active site 446465001952 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446465001953 Cation efflux family; Region: Cation_efflux; cl00316 446465001954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465001955 dimerization interface [polypeptide binding]; other site 446465001956 putative DNA binding site [nucleotide binding]; other site 446465001957 putative Zn2+ binding site [ion binding]; other site 446465001958 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 446465001959 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465001960 ATP binding site [chemical binding]; other site 446465001961 Mg++ binding site [ion binding]; other site 446465001962 motif III; other site 446465001963 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465001964 nucleotide binding region [chemical binding]; other site 446465001965 ATP-binding site [chemical binding]; other site 446465001966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001968 DNA binding site [nucleotide binding] 446465001969 domain linker motif; other site 446465001970 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465001971 ligand binding site [chemical binding]; other site 446465001972 dimerization interface [polypeptide binding]; other site 446465001973 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446465001974 domain; Region: Glyco_hydro_2; pfam00703 446465001975 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 446465001976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465001977 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446465001978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465001979 Coenzyme A binding pocket [chemical binding]; other site 446465001980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465001981 Predicted transcriptional regulators [Transcription]; Region: COG1725 446465001982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465001983 DNA-binding site [nucleotide binding]; DNA binding site 446465001984 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446465001985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465001986 Walker A/P-loop; other site 446465001987 ATP binding site [chemical binding]; other site 446465001988 Q-loop/lid; other site 446465001989 ABC transporter signature motif; other site 446465001990 Walker B; other site 446465001991 D-loop; other site 446465001992 H-loop/switch region; other site 446465001993 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 446465001994 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446465001995 putative NAD(P) binding site [chemical binding]; other site 446465001996 catalytic Zn binding site [ion binding]; other site 446465001997 structural Zn binding site [ion binding]; other site 446465001998 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 446465001999 RNA/DNA hybrid binding site [nucleotide binding]; other site 446465002000 active site 446465002001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 446465002002 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 446465002003 Predicted membrane protein [Function unknown]; Region: COG2311 446465002004 Protein of unknown function (DUF418); Region: DUF418; cl12135 446465002005 Protein of unknown function (DUF418); Region: DUF418; cl12135 446465002006 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 446465002007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 446465002008 dimer interface [polypeptide binding]; other site 446465002009 phosphorylation site [posttranslational modification] 446465002010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465002011 ATP binding site [chemical binding]; other site 446465002012 Mg2+ binding site [ion binding]; other site 446465002013 G-X-G motif; other site 446465002014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465002015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465002016 active site 446465002017 phosphorylation site [posttranslational modification] 446465002018 intermolecular recognition site; other site 446465002019 dimerization interface [polypeptide binding]; other site 446465002020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 446465002021 DNA binding site [nucleotide binding] 446465002022 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 446465002023 DNA repair helicase rad25; Region: rad25; TIGR00603 446465002024 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446465002025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 446465002026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 446465002027 ATP binding site [chemical binding]; other site 446465002028 putative Mg++ binding site [ion binding]; other site 446465002029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465002030 nucleotide binding region [chemical binding]; other site 446465002031 ATP-binding site [chemical binding]; other site 446465002032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465002033 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 446465002034 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 446465002035 RDD family; Region: RDD; cl00746 446465002036 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 446465002037 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 446465002038 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465002039 catalytic residue [active] 446465002040 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465002041 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465002042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002043 putative substrate translocation pore; other site 446465002044 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 446465002045 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446465002046 homodimer interface [polypeptide binding]; other site 446465002047 substrate-cofactor binding pocket; other site 446465002048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465002049 catalytic residue [active] 446465002050 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 446465002051 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 446465002052 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446465002053 putative active site [active] 446465002054 catalytic site [active] 446465002055 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 446465002056 putative active site [active] 446465002057 catalytic site [active] 446465002058 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446465002059 dimer interface [polypeptide binding]; other site 446465002060 substrate binding site [chemical binding]; other site 446465002061 ATP binding site [chemical binding]; other site 446465002062 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465002063 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 446465002064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465002065 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446465002066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465002067 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 446465002068 allantoinase; Region: allantoinase; TIGR03178 446465002069 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465002070 active site 446465002071 Glycerate kinase family; Region: Gly_kinase; cl00841 446465002072 glyoxylate carboligase; Provisional; Region: PRK11269 446465002073 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446465002074 PYR/PP interface [polypeptide binding]; other site 446465002075 dimer interface [polypeptide binding]; other site 446465002076 TPP binding site [chemical binding]; other site 446465002077 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446465002078 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 446465002079 TPP-binding site [chemical binding]; other site 446465002080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465002081 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 446465002082 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 446465002083 hypothetical protein; Provisional; Region: PRK11171 446465002084 Cupin domain; Region: Cupin_2; cl09118 446465002085 Cupin domain; Region: Cupin_2; cl09118 446465002086 malate synthase A; Region: malate_syn_A; TIGR01344 446465002087 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 446465002088 active site 446465002089 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446465002090 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 446465002091 putative NAD(P) binding site [chemical binding]; other site 446465002092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465002093 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465002094 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465002095 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 446465002096 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 446465002097 dimer interface [polypeptide binding]; other site 446465002098 TPP-binding site [chemical binding]; other site 446465002099 Permease family; Region: Xan_ur_permease; pfam00860 446465002100 Sulfate transporter family; Region: Sulfate_transp; cl00967 446465002101 urate oxidase; Region: urate_oxi; TIGR03383 446465002102 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 446465002103 active site 446465002104 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 446465002105 active site 446465002106 homotetramer interface [polypeptide binding]; other site 446465002107 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 446465002108 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 446465002109 catalytic triad [active] 446465002110 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 446465002111 catalytic site [active] 446465002112 Asp-box motif; other site 446465002113 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 446465002114 catalytic site [active] 446465002115 Asp-box motif; other site 446465002116 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 446465002117 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 446465002118 putative active site cavity [active] 446465002119 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465002120 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446465002121 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446465002122 active site 446465002123 inhibitor site; inhibition site 446465002124 dimer interface [polypeptide binding]; other site 446465002125 catalytic residue [active] 446465002126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 446465002127 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465002128 Walker A/P-loop; other site 446465002129 ATP binding site [chemical binding]; other site 446465002130 Q-loop/lid; other site 446465002131 ABC transporter signature motif; other site 446465002132 Walker B; other site 446465002133 D-loop; other site 446465002134 H-loop/switch region; other site 446465002135 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446465002136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465002137 dimer interface [polypeptide binding]; other site 446465002138 conserved gate region; other site 446465002139 putative PBP binding loops; other site 446465002140 ABC-ATPase subunit interface; other site 446465002141 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446465002142 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465002143 Walker A/P-loop; other site 446465002144 ATP binding site [chemical binding]; other site 446465002145 Q-loop/lid; other site 446465002146 ABC transporter signature motif; other site 446465002147 Walker B; other site 446465002148 D-loop; other site 446465002149 H-loop/switch region; other site 446465002150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465002151 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465002152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465002153 dimer interface [polypeptide binding]; other site 446465002154 conserved gate region; other site 446465002155 putative PBP binding loops; other site 446465002156 ABC-ATPase subunit interface; other site 446465002157 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446465002158 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465002159 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465002160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465002161 DNA-binding site [nucleotide binding]; DNA binding site 446465002162 FCD domain; Region: FCD; cl11656 446465002163 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 446465002164 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 446465002165 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446465002166 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465002167 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465002168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465002169 Walker A motif; other site 446465002170 ATP binding site [chemical binding]; other site 446465002171 Walker B motif; other site 446465002172 arginine finger; other site 446465002173 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465002174 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465002175 Walker A/P-loop; other site 446465002176 ATP binding site [chemical binding]; other site 446465002177 Q-loop/lid; other site 446465002178 ABC transporter signature motif; other site 446465002179 Walker B; other site 446465002180 D-loop; other site 446465002181 H-loop/switch region; other site 446465002182 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465002183 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465002184 Walker A/P-loop; other site 446465002185 ATP binding site [chemical binding]; other site 446465002186 Q-loop/lid; other site 446465002187 ABC transporter signature motif; other site 446465002188 Walker B; other site 446465002189 D-loop; other site 446465002190 H-loop/switch region; other site 446465002191 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465002192 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 446465002193 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465002194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465002195 dimer interface [polypeptide binding]; other site 446465002196 conserved gate region; other site 446465002197 putative PBP binding loops; other site 446465002198 ABC-ATPase subunit interface; other site 446465002199 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465002200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465002201 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446465002202 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446465002203 putative NAD(P) binding site [chemical binding]; other site 446465002204 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446465002205 dimer interface [polypeptide binding]; other site 446465002206 putative functional site; other site 446465002207 putative MPT binding site; other site 446465002208 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 446465002209 ATP binding site [chemical binding]; other site 446465002210 substrate interface [chemical binding]; other site 446465002211 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446465002212 active site residue [active] 446465002213 Ubiquitin-like proteins; Region: UBQ; cl00155 446465002214 charged pocket; other site 446465002215 hydrophobic patch; other site 446465002216 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 446465002217 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 446465002218 FeS/SAM binding site; other site 446465002219 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 446465002220 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446465002221 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446465002222 dimer interface [polypeptide binding]; other site 446465002223 putative functional site; other site 446465002224 putative MPT binding site; other site 446465002225 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 446465002226 trimer interface [polypeptide binding]; other site 446465002227 dimer interface [polypeptide binding]; other site 446465002228 putative active site [active] 446465002229 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 446465002230 MPT binding site; other site 446465002231 trimer interface [polypeptide binding]; other site 446465002232 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 446465002233 MoaE homodimer interface [polypeptide binding]; other site 446465002234 MoaD interaction [polypeptide binding]; other site 446465002235 active site residues [active] 446465002236 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465002237 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465002238 active site 446465002239 metal binding site [ion binding]; metal-binding site 446465002240 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 446465002241 oligomerisation interface [polypeptide binding]; other site 446465002242 mobile loop; other site 446465002243 roof hairpin; other site 446465002244 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446465002245 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446465002246 ring oligomerisation interface [polypeptide binding]; other site 446465002247 ATP/Mg binding site [chemical binding]; other site 446465002248 stacking interactions; other site 446465002249 hinge regions; other site 446465002250 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 446465002251 active site 446465002252 Phosphate transporter family; Region: PHO4; cl00396 446465002253 Phosphate transporter family; Region: PHO4; cl00396 446465002254 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 446465002255 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446465002256 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 446465002257 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 446465002258 active site 446465002259 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446465002260 dimer interface [polypeptide binding]; other site 446465002261 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446465002262 active site 446465002263 substrate binding site [chemical binding]; other site 446465002264 catalytic site [active] 446465002265 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 446465002266 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446465002267 phosphate binding site [ion binding]; other site 446465002268 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 446465002269 heme binding pocket [chemical binding]; other site 446465002270 Acetokinase family; Region: Acetate_kinase; cl01029 446465002271 phosphate acetyltransferase; Reviewed; Region: PRK05632 446465002272 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 446465002273 DRTGG domain; Region: DRTGG; cl12147 446465002274 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 446465002275 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446465002276 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 446465002277 GMP synthase; Reviewed; Region: guaA; PRK00074 446465002278 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 446465002279 AMP/PPi binding site [chemical binding]; other site 446465002280 candidate oxyanion hole; other site 446465002281 catalytic triad [active] 446465002282 potential glutamine specificity residues [chemical binding]; other site 446465002283 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 446465002284 ATP Binding subdomain [chemical binding]; other site 446465002285 Ligand Binding sites [chemical binding]; other site 446465002286 Dimerization subdomain; other site 446465002287 benzoate transport; Region: 2A0115; TIGR00895 446465002288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002289 putative substrate translocation pore; other site 446465002290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465002293 putative substrate translocation pore; other site 446465002294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002295 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446465002296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465002297 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465002298 catalytic core [active] 446465002299 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 446465002300 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446465002301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465002302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465002303 motif II; other site 446465002304 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 446465002305 putative active site [active] 446465002306 dimerization interface [polypeptide binding]; other site 446465002307 putative tRNAtyr binding site [nucleotide binding]; other site 446465002308 Phosphotransferase enzyme family; Region: APH; pfam01636 446465002309 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465002310 active site 446465002311 ATP binding site [chemical binding]; other site 446465002312 substrate binding site [chemical binding]; other site 446465002313 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446465002314 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 446465002315 adenylosuccinate synthetase; Provisional; Region: PRK01117 446465002316 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 446465002317 GDP-binding site [chemical binding]; other site 446465002318 ACT binding site; other site 446465002319 IMP binding site; other site 446465002320 CutC family; Region: CutC; cl01218 446465002321 amidophosphoribosyltransferase; Provisional; Region: PRK07847 446465002322 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 446465002323 active site 446465002324 tetramer interface [polypeptide binding]; other site 446465002325 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465002326 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 446465002327 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 446465002328 dimerization interface [polypeptide binding]; other site 446465002329 putative ATP binding site [chemical binding]; other site 446465002330 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 446465002331 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446465002332 DNA binding residues [nucleotide binding] 446465002333 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446465002334 UvrD/REP helicase; Region: UvrD-helicase; cl14126 446465002335 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 446465002336 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 446465002337 putative dimer interface [polypeptide binding]; other site 446465002338 ligand binding site [chemical binding]; other site 446465002339 Zn binding site [ion binding]; other site 446465002340 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 446465002341 Multicopper oxidase; Region: Cu-oxidase; cl14658 446465002342 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 446465002343 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465002344 CoA-ligase; Region: Ligase_CoA; pfam00549 446465002345 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 446465002346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465002347 CoA-ligase; Region: Ligase_CoA; pfam00549 446465002348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465002349 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 446465002350 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446465002351 NlpC/P60 family; Region: NLPC_P60; cl11438 446465002352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465002353 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446465002354 active site 446465002355 motif I; other site 446465002356 motif II; other site 446465002357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465002358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465002359 mycothione reductase; Reviewed; Region: PRK07846 446465002360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465002361 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446465002362 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446465002363 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 446465002364 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446465002365 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 446465002366 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 446465002367 active site 446465002368 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 446465002369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465002370 NAD(P) binding site [chemical binding]; other site 446465002371 active site 446465002372 threonine dehydratase; Validated; Region: PRK08639 446465002373 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 446465002374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465002375 catalytic residue [active] 446465002376 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446465002377 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cl10030 446465002378 homotrimer interaction site [polypeptide binding]; other site 446465002379 zinc binding site [ion binding]; other site 446465002380 CDP-binding sites; other site 446465002381 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 446465002382 P-loop; other site 446465002383 active site 446465002384 phosphorylation site [posttranslational modification] 446465002385 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 446465002386 substrate binding site [chemical binding]; other site 446465002387 dimer interface [polypeptide binding]; other site 446465002388 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465002389 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 446465002390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465002391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465002392 active site 446465002393 phosphorylation site [posttranslational modification] 446465002394 intermolecular recognition site; other site 446465002395 dimerization interface [polypeptide binding]; other site 446465002396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 446465002397 DNA binding site [nucleotide binding] 446465002398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 446465002399 dimer interface [polypeptide binding]; other site 446465002400 phosphorylation site [posttranslational modification] 446465002401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465002402 ATP binding site [chemical binding]; other site 446465002403 Mg2+ binding site [ion binding]; other site 446465002404 G-X-G motif; other site 446465002405 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 446465002406 PhoU domain; Region: PhoU; pfam01895 446465002407 PhoU domain; Region: PhoU; pfam01895 446465002408 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446465002409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465002410 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 446465002411 iron-sulfur cluster [ion binding]; other site 446465002412 [2Fe-2S] cluster binding site [ion binding]; other site 446465002413 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 446465002414 active site 446465002415 catalytic residues [active] 446465002416 metal binding site [ion binding]; metal-binding site 446465002417 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 446465002418 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 446465002419 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 446465002420 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 446465002421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465002422 motif II; other site 446465002423 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465002424 hydrophobic ligand binding site; other site 446465002425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002426 putative substrate translocation pore; other site 446465002427 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 446465002428 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 446465002429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465002430 Walker A/P-loop; other site 446465002431 ATP binding site [chemical binding]; other site 446465002432 Q-loop/lid; other site 446465002433 ABC transporter signature motif; other site 446465002434 Walker B; other site 446465002435 D-loop; other site 446465002436 H-loop/switch region; other site 446465002437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465002438 S-adenosylmethionine binding site [chemical binding]; other site 446465002439 methionine aminotransferase; Validated; Region: PRK09082 446465002440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465002441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465002442 homodimer interface [polypeptide binding]; other site 446465002443 catalytic residue [active] 446465002444 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 446465002445 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446465002446 DNA binding site [nucleotide binding] 446465002447 active site 446465002448 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 446465002449 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 446465002450 AlkA N-terminal domain; Region: AlkA_N; pfam06029 446465002451 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 446465002452 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446465002453 minor groove reading motif; other site 446465002454 helix-hairpin-helix signature motif; other site 446465002455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465002456 trigger factor; Provisional; Region: tig; PRK01490 446465002457 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 446465002458 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 446465002459 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 446465002460 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446465002461 NlpC/P60 family; Region: NLPC_P60; cl11438 446465002462 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446465002463 oligomer interface [polypeptide binding]; other site 446465002464 active site residues [active] 446465002465 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446465002466 oligomer interface [polypeptide binding]; other site 446465002467 active site residues [active] 446465002468 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 446465002469 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 446465002470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465002471 Walker A motif; other site 446465002472 ATP binding site [chemical binding]; other site 446465002473 Walker B motif; other site 446465002474 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446465002475 Chorismate mutase type II; Region: CM_2; cl00693 446465002476 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 446465002477 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 446465002478 molybdopterin cofactor binding site; other site 446465002479 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 446465002480 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 446465002481 molybdopterin cofactor binding site; other site 446465002482 Fe-S containing; Region: FDH-beta; TIGR01582 446465002483 4Fe-4S binding domain; Region: Fer4; cl02805 446465002484 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 446465002485 selenophosphate synthetase; Provisional; Region: PRK00943 446465002486 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 446465002487 dimerization interface [polypeptide binding]; other site 446465002488 putative ATP binding site [chemical binding]; other site 446465002489 selenocysteine synthase; Provisional; Region: PRK04311 446465002490 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446465002491 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 446465002492 translation initiation factor IF-2 subunit gamma; Validated; Region: PRK04000 446465002493 G1 box; other site 446465002494 putative GEF interaction site [polypeptide binding]; other site 446465002495 GTP/Mg2+ binding site [chemical binding]; other site 446465002496 Switch I region; other site 446465002497 G2 box; other site 446465002498 G3 box; other site 446465002499 Switch II region; other site 446465002500 G4 box; other site 446465002501 G5 box; other site 446465002502 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 446465002503 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 446465002504 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 446465002505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465002506 active site 446465002507 HIGH motif; other site 446465002508 nucleotide binding site [chemical binding]; other site 446465002509 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465002510 active site 446465002511 KMSKS motif; other site 446465002512 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 446465002513 tRNA binding surface [nucleotide binding]; other site 446465002514 anticodon binding site; other site 446465002515 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465002516 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465002517 active site 446465002518 metal binding site [ion binding]; metal-binding site 446465002519 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446465002520 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 446465002521 dimer interface [polypeptide binding]; other site 446465002522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465002523 catalytic residue [active] 446465002524 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 446465002525 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446465002526 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446465002527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465002528 Walker A/P-loop; other site 446465002529 ATP binding site [chemical binding]; other site 446465002530 Q-loop/lid; other site 446465002531 ABC transporter signature motif; other site 446465002532 Walker B; other site 446465002533 D-loop; other site 446465002534 H-loop/switch region; other site 446465002535 Protein of unknown function (DUF990); Region: DUF990; cl01496 446465002536 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 446465002537 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 446465002538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465002539 Cation efflux family; Region: Cation_efflux; cl00316 446465002540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465002541 short chain dehydrogenase; Provisional; Region: PRK07677 446465002542 NAD(P) binding site [chemical binding]; other site 446465002543 active site 446465002544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465002545 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465002546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465002547 Walker A/P-loop; other site 446465002548 ATP binding site [chemical binding]; other site 446465002549 Q-loop/lid; other site 446465002550 ABC transporter signature motif; other site 446465002551 Walker B; other site 446465002552 D-loop; other site 446465002553 H-loop/switch region; other site 446465002554 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446465002555 catalytic loop [active] 446465002556 iron binding site [ion binding]; other site 446465002557 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 446465002558 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446465002559 HIGH motif; other site 446465002560 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446465002561 active site 446465002562 KMSKS motif; other site 446465002563 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 446465002564 tRNA binding surface [nucleotide binding]; other site 446465002565 anticodon binding site; other site 446465002566 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 446465002567 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465002568 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446465002569 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 446465002570 active site 446465002571 multimer interface [polypeptide binding]; other site 446465002572 signal recognition particle protein; Provisional; Region: PRK10867 446465002573 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 446465002574 P loop; other site 446465002575 GTP binding site [chemical binding]; other site 446465002576 Signal peptide binding domain; Region: SRP_SPB; pfam02978 446465002577 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465002578 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446465002579 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465002580 active site 446465002581 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 446465002582 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 446465002583 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 446465002584 RimM N-terminal domain; Region: RimM; pfam01782 446465002585 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 446465002586 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 446465002587 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446465002588 Catalytic site [active] 446465002589 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446465002590 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446465002591 Catalytic site [active] 446465002592 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 446465002593 RNA/DNA hybrid binding site [nucleotide binding]; other site 446465002594 active site 446465002595 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 446465002596 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 446465002597 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 446465002598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465002599 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 446465002600 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446465002601 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446465002602 DNA binding site [nucleotide binding] 446465002603 Int/Topo IB signature motif; other site 446465002604 active site 446465002605 Peptidase family M23; Region: Peptidase_M23; pfam01551 446465002606 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 446465002607 rRNA interaction site [nucleotide binding]; other site 446465002608 S8 interaction site; other site 446465002609 putative laminin-1 binding site; other site 446465002610 elongation factor Ts; Provisional; Region: tsf; PRK09377 446465002611 Elongation factor TS; Region: EF_TS; pfam00889 446465002612 Elongation factor TS; Region: EF_TS; pfam00889 446465002613 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 446465002614 putative nucleotide binding site [chemical binding]; other site 446465002615 uridine monophosphate binding site [chemical binding]; other site 446465002616 homohexameric interface [polypeptide binding]; other site 446465002617 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 446465002618 hinge region; other site 446465002619 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 446465002620 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 446465002621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 446465002622 FeS/SAM binding site; other site 446465002623 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 446465002624 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 446465002625 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 446465002626 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 446465002627 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 446465002628 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 446465002629 active site 446465002630 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 446465002631 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 446465002632 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 446465002633 Predicted acetyltransferase [General function prediction only]; Region: COG3393 446465002634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465002635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465002636 S-adenosylmethionine binding site [chemical binding]; other site 446465002637 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446465002638 prolyl-tRNA synthetase; Provisional; Region: PRK09194 446465002639 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 446465002640 dimer interface [polypeptide binding]; other site 446465002641 motif 1; other site 446465002642 active site 446465002643 motif 2; other site 446465002644 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 446465002645 putative deacylase active site [active] 446465002646 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446465002647 active site 446465002648 motif 3; other site 446465002649 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 446465002650 anticodon binding site; other site 446465002651 ribosome maturation protein RimP; Reviewed; Region: PRK00092 446465002652 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 446465002653 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 446465002654 NusA N-terminal domain; Region: NusA_N; pfam08529 446465002655 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 446465002656 RNA binding site [nucleotide binding]; other site 446465002657 homodimer interface [polypeptide binding]; other site 446465002658 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 446465002659 G-X-X-G motif; other site 446465002660 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 446465002661 putative RNA binding cleft [nucleotide binding]; other site 446465002662 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446465002663 translation initiation factor IF-2; Region: IF-2; TIGR00487 446465002664 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446465002665 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 446465002666 G1 box; other site 446465002667 putative GEF interaction site [polypeptide binding]; other site 446465002668 GTP/Mg2+ binding site [chemical binding]; other site 446465002669 Switch I region; other site 446465002670 G2 box; other site 446465002671 G3 box; other site 446465002672 Switch II region; other site 446465002673 G4 box; other site 446465002674 G5 box; other site 446465002675 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 446465002676 Translation-initiation factor 2; Region: IF-2; pfam11987 446465002677 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 446465002678 Ribosome-binding factor A; Region: RBFA; cl00542 446465002679 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 446465002680 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 446465002681 RNA binding site [nucleotide binding]; other site 446465002682 active site 446465002683 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446465002684 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446465002685 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446465002686 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 446465002687 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 446465002688 active site 446465002689 Riboflavin kinase; Region: Flavokinase; pfam01687 446465002690 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 446465002691 16S/18S rRNA binding site [nucleotide binding]; other site 446465002692 S13e-L30e interaction site [polypeptide binding]; other site 446465002693 25S rRNA binding site [nucleotide binding]; other site 446465002694 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 446465002695 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 446465002696 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 446465002697 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 446465002698 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 446465002699 putative nucleic acid binding region [nucleotide binding]; other site 446465002700 G-X-X-G motif; other site 446465002701 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 446465002702 RNA binding site [nucleotide binding]; other site 446465002703 domain interface; other site 446465002704 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446465002705 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446465002706 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446465002707 dihydrodipicolinate reductase; Provisional; Region: PRK00048 446465002708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465002709 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 446465002710 AzlC protein; Region: AzlC; cl00570 446465002711 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446465002712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465002713 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 446465002714 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 446465002715 active site 446465002716 dimer interface [polypeptide binding]; other site 446465002717 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 446465002718 Ligand Binding Site [chemical binding]; other site 446465002719 Molecular Tunnel; other site 446465002720 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 446465002721 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446465002722 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 446465002723 dimer interface [polypeptide binding]; other site 446465002724 active site 446465002725 catalytic residue [active] 446465002726 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446465002727 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465002728 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446465002729 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 446465002730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465002731 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 446465002732 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446465002733 Competence-damaged protein; Region: CinA; cl00666 446465002734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 446465002735 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 446465002736 recombinase A; Provisional; Region: recA; PRK09354 446465002737 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 446465002738 hexamer interface [polypeptide binding]; other site 446465002739 Walker A motif; other site 446465002740 ATP binding site [chemical binding]; other site 446465002741 Walker B motif; other site 446465002742 RecX family; Region: RecX; cl00936 446465002743 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 446465002744 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446465002745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 446465002746 FeS/SAM binding site; other site 446465002747 IPP transferase; Region: IPPT; cl00403 446465002748 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 446465002749 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 446465002750 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 446465002751 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 446465002752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465002753 S-adenosylmethionine binding site [chemical binding]; other site 446465002754 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 446465002755 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 446465002756 G1 box; other site 446465002757 GTP/Mg2+ binding site [chemical binding]; other site 446465002758 Switch I region; other site 446465002759 G2 box; other site 446465002760 G3 box; other site 446465002761 Switch II region; other site 446465002762 G4 box; other site 446465002763 G5 box; other site 446465002764 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 446465002765 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 446465002766 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 446465002767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465002768 LexA repressor; Validated; Region: PRK00215 446465002769 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 446465002770 Catalytic site [active] 446465002771 cell division suppressor protein YneA; Provisional; Region: PRK14125 446465002772 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 446465002773 ATP cone domain; Region: ATP-cone; pfam03477 446465002774 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446465002775 UvrD/REP helicase; Region: UvrD-helicase; cl14126 446465002776 PAC2 family; Region: PAC2; cl00847 446465002777 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 446465002778 DNA-binding site [nucleotide binding]; DNA binding site 446465002779 RNA-binding motif; other site 446465002780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465002781 DNA polymerase IV; Validated; Region: PRK03858 446465002782 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 446465002783 active site 446465002784 DNA binding site [nucleotide binding] 446465002785 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446465002786 cell division protein MraZ; Reviewed; Region: PRK00326 446465002787 MraZ protein; Region: MraZ; pfam02381 446465002788 MraZ protein; Region: MraZ; pfam02381 446465002789 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 446465002790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465002791 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446465002792 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446465002793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 446465002794 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 446465002795 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465002796 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446465002797 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 446465002798 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446465002799 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465002800 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446465002801 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 446465002802 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 446465002803 Mg++ binding site [ion binding]; other site 446465002804 putative catalytic motif [active] 446465002805 putative substrate binding site [chemical binding]; other site 446465002806 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 446465002807 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465002808 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 446465002809 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 446465002810 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 446465002811 active site 446465002812 homodimer interface [polypeptide binding]; other site 446465002813 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 446465002814 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446465002815 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465002816 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 446465002817 Cell division protein FtsQ; Region: FtsQ; pfam03799 446465002818 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 446465002819 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 446465002820 nucleotide binding site [chemical binding]; other site 446465002821 SulA interaction site; other site 446465002822 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 446465002823 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 446465002824 Protein of unknown function (DUF552); Region: DUF552; cl00775 446465002825 DivIVA protein; Region: DivIVA; pfam05103 446465002826 DivIVA domain; Region: DivI1A_domain; TIGR03544 446465002827 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 446465002828 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 446465002829 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465002830 RNA binding surface [nucleotide binding]; other site 446465002831 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 446465002832 active site 446465002833 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465002834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465002835 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 446465002836 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 446465002837 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 446465002838 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 446465002839 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465002840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465002841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465002842 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465002843 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465002844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465002845 dimer interface [polypeptide binding]; other site 446465002846 conserved gate region; other site 446465002847 putative PBP binding loops; other site 446465002848 ABC-ATPase subunit interface; other site 446465002849 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 446465002850 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 446465002851 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 446465002852 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 446465002853 generic binding surface II; other site 446465002854 generic binding surface I; other site 446465002855 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465002856 putative catalytic site [active] 446465002857 putative metal binding site [ion binding]; other site 446465002858 putative phosphate binding site [ion binding]; other site 446465002859 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446465002860 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465002861 active site 446465002862 6-phosphofructokinase; Provisional; Region: PRK03202 446465002863 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 446465002864 active site 446465002865 ADP/pyrophosphate binding site [chemical binding]; other site 446465002866 dimerization interface [polypeptide binding]; other site 446465002867 allosteric effector site; other site 446465002868 fructose-1,6-bisphosphate binding site; other site 446465002869 metabolite-proton symporter; Region: 2A0106; TIGR00883 446465002870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002871 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 446465002872 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 446465002873 active site 446465002874 dimer interface [polypeptide binding]; other site 446465002875 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 446465002876 dimer interface [polypeptide binding]; other site 446465002877 active site 446465002878 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446465002879 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465002880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465002881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465002882 dimer interface [polypeptide binding]; other site 446465002883 conserved gate region; other site 446465002884 putative PBP binding loops; other site 446465002885 ABC-ATPase subunit interface; other site 446465002886 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446465002887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465002888 dimer interface [polypeptide binding]; other site 446465002889 conserved gate region; other site 446465002890 putative PBP binding loops; other site 446465002891 ABC-ATPase subunit interface; other site 446465002892 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465002893 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 446465002894 Walker A/P-loop; other site 446465002895 ATP binding site [chemical binding]; other site 446465002896 Q-loop/lid; other site 446465002897 ABC transporter signature motif; other site 446465002898 Walker B; other site 446465002899 D-loop; other site 446465002900 H-loop/switch region; other site 446465002901 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465002902 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465002903 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465002904 Walker A/P-loop; other site 446465002905 ATP binding site [chemical binding]; other site 446465002906 Q-loop/lid; other site 446465002907 ABC transporter signature motif; other site 446465002908 Walker B; other site 446465002909 D-loop; other site 446465002910 H-loop/switch region; other site 446465002911 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465002912 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 446465002913 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 446465002914 G1 box; other site 446465002915 putative GEF interaction site [polypeptide binding]; other site 446465002916 GTP/Mg2+ binding site [chemical binding]; other site 446465002917 Switch I region; other site 446465002918 G2 box; other site 446465002919 G3 box; other site 446465002920 Switch II region; other site 446465002921 G4 box; other site 446465002922 G5 box; other site 446465002923 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 446465002924 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 446465002925 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446465002926 Ferredoxin [Energy production and conversion]; Region: COG1146 446465002927 4Fe-4S binding domain; Region: Fer4; cl02805 446465002928 aspartate aminotransferase; Provisional; Region: PRK07681 446465002929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465002930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465002931 homodimer interface [polypeptide binding]; other site 446465002932 catalytic residue [active] 446465002933 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 446465002934 dimer interface [polypeptide binding]; other site 446465002935 Citrate synthase; Region: Citrate_synt; pfam00285 446465002936 active site 446465002937 citrylCoA binding site [chemical binding]; other site 446465002938 NADH binding [chemical binding]; other site 446465002939 cationic pore residues; other site 446465002940 oxalacetate/citrate binding site [chemical binding]; other site 446465002941 coenzyme A binding site [chemical binding]; other site 446465002942 catalytic triad [active] 446465002943 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 446465002944 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 446465002945 putative trimer interface [polypeptide binding]; other site 446465002946 putative CoA binding site [chemical binding]; other site 446465002947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 446465002948 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 446465002949 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 446465002950 metal binding site [ion binding]; metal-binding site 446465002951 putative dimer interface [polypeptide binding]; other site 446465002952 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 446465002953 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 446465002954 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446465002955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465002956 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446465002957 Domain of unknown function DUF59; Region: DUF59; cl00941 446465002958 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 446465002959 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 446465002960 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 446465002961 MgtE intracellular N domain; Region: MgtE_N; cl15244 446465002962 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446465002963 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 446465002964 proline aminopeptidase P II; Provisional; Region: PRK10879 446465002965 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 446465002966 active site 446465002967 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 446465002968 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 446465002969 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 446465002970 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465002971 ATP binding site [chemical binding]; other site 446465002972 Mg++ binding site [ion binding]; other site 446465002973 motif III; other site 446465002974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465002975 nucleotide binding region [chemical binding]; other site 446465002976 ATP-binding site [chemical binding]; other site 446465002977 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465002978 active site 446465002979 metal binding site [ion binding]; metal-binding site 446465002980 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 446465002981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465002982 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 446465002983 G1 box; other site 446465002984 GTP/Mg2+ binding site [chemical binding]; other site 446465002985 G2 box; other site 446465002986 Switch I region; other site 446465002987 G3 box; other site 446465002988 Switch II region; other site 446465002989 UvrD/REP helicase; Region: UvrD-helicase; cl14126 446465002990 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446465002991 UvrD/REP helicase; Region: UvrD-helicase; cl14126 446465002992 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 446465002993 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446465002994 Phosphotransferase enzyme family; Region: APH; pfam01636 446465002995 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465002996 substrate binding site [chemical binding]; other site 446465002997 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 446465002998 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 446465002999 putative NADH binding site [chemical binding]; other site 446465003000 putative active site [active] 446465003001 nudix motif; other site 446465003002 putative metal binding site [ion binding]; other site 446465003003 UvrD/REP helicase; Region: UvrD-helicase; cl14126 446465003004 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 446465003005 UvrD/REP helicase; Region: UvrD-helicase; cl14126 446465003006 HRDC domain; Region: HRDC; cl02578 446465003007 Transcription factor WhiB; Region: Whib; pfam02467 446465003008 Protein of unknown function DUF45; Region: DUF45; cl00636 446465003009 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465003010 nudix motif; other site 446465003011 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 446465003012 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 446465003013 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 446465003014 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446465003015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465003016 motif II; other site 446465003017 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 446465003018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465003019 Walker A/P-loop; other site 446465003020 ATP binding site [chemical binding]; other site 446465003021 Q-loop/lid; other site 446465003022 ABC transporter signature motif; other site 446465003023 Walker B; other site 446465003024 D-loop; other site 446465003025 H-loop/switch region; other site 446465003026 ABC transporter; Region: ABC_tran_2; pfam12848 446465003027 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 446465003028 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465003029 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 446465003030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465003031 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465003032 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 446465003033 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 446465003034 active site 446465003035 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 446465003036 catalytic triad [active] 446465003037 dimer interface [polypeptide binding]; other site 446465003038 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 446465003039 active site 446465003040 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 446465003041 apolar tunnel; other site 446465003042 heme binding site [chemical binding]; other site 446465003043 dimerization interface [polypeptide binding]; other site 446465003044 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446465003045 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 446465003046 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 446465003047 Zn binding site [ion binding]; other site 446465003048 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 446465003049 Protein of unknown function (DUF402); Region: DUF402; cl00979 446465003050 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446465003051 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 446465003052 putative di-iron ligands [ion binding]; other site 446465003053 Histidine kinase; Region: HisKA_3; pfam07730 446465003054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465003055 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465003056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465003057 active site 446465003058 phosphorylation site [posttranslational modification] 446465003059 intermolecular recognition site; other site 446465003060 dimerization interface [polypeptide binding]; other site 446465003061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 446465003062 DNA binding residues [nucleotide binding] 446465003063 dimerization interface [polypeptide binding]; other site 446465003064 Protein kinase domain; Region: Pkinase; pfam00069 446465003065 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465003066 active site 446465003067 ATP binding site [chemical binding]; other site 446465003068 substrate binding site [chemical binding]; other site 446465003069 activation loop (A-loop); other site 446465003070 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465003071 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465003072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465003073 Walker A/P-loop; other site 446465003074 ATP binding site [chemical binding]; other site 446465003075 Q-loop/lid; other site 446465003076 ABC transporter signature motif; other site 446465003077 Walker B; other site 446465003078 D-loop; other site 446465003079 H-loop/switch region; other site 446465003080 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465003081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465003082 ABC transporter signature motif; other site 446465003083 Walker B; other site 446465003084 D-loop; other site 446465003085 H-loop/switch region; other site 446465003086 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 446465003087 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446465003088 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 446465003089 putative DNA binding site [nucleotide binding]; other site 446465003090 catalytic residue [active] 446465003091 putative H2TH interface [polypeptide binding]; other site 446465003092 putative catalytic residues [active] 446465003093 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446465003094 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446465003095 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465003097 DNA binding site [nucleotide binding] 446465003098 domain linker motif; other site 446465003099 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465003100 dimerization interface [polypeptide binding]; other site 446465003101 ligand binding site [chemical binding]; other site 446465003102 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 446465003103 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446465003104 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 446465003105 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 446465003106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465003107 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446465003108 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446465003109 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 446465003110 Walker A/P-loop; other site 446465003111 ATP binding site [chemical binding]; other site 446465003112 Q-loop/lid; other site 446465003113 ABC transporter signature motif; other site 446465003114 Walker B; other site 446465003115 D-loop; other site 446465003116 H-loop/switch region; other site 446465003117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465003118 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446465003119 Walker A/P-loop; other site 446465003120 ATP binding site [chemical binding]; other site 446465003121 Q-loop/lid; other site 446465003122 ABC transporter signature motif; other site 446465003123 Walker B; other site 446465003124 D-loop; other site 446465003125 H-loop/switch region; other site 446465003126 Cobalt transport protein; Region: CbiQ; cl00463 446465003127 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 446465003128 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 446465003129 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 446465003130 active site 446465003131 Zn binding site [ion binding]; other site 446465003132 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 446465003133 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465003134 putative catalytic site [active] 446465003135 putative metal binding site [ion binding]; other site 446465003136 putative phosphate binding site [ion binding]; other site 446465003137 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465003138 putative catalytic site [active] 446465003139 putative phosphate binding site [ion binding]; other site 446465003140 putative metal binding site [ion binding]; other site 446465003141 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446465003142 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446465003143 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 446465003144 putative ADP-binding pocket [chemical binding]; other site 446465003145 Transposase; Region: DEDD_Tnp_IS110; pfam01548 446465003146 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 446465003147 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 446465003148 Integrase core domain; Region: rve; cl01316 446465003149 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 446465003150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465003151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465003152 active site 446465003153 phosphorylation site [posttranslational modification] 446465003154 intermolecular recognition site; other site 446465003155 dimerization interface [polypeptide binding]; other site 446465003156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 446465003157 DNA binding residues [nucleotide binding] 446465003158 dimerization interface [polypeptide binding]; other site 446465003159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465003160 Histidine kinase; Region: HisKA_3; pfam07730 446465003161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465003162 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446465003163 active site 446465003164 metal binding site [ion binding]; metal-binding site 446465003165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465003166 dimerization interface [polypeptide binding]; other site 446465003167 putative DNA binding site [nucleotide binding]; other site 446465003168 putative Zn2+ binding site [ion binding]; other site 446465003169 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465003170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465003171 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446465003172 NAD(P) binding site [chemical binding]; other site 446465003173 active site 446465003174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465003175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465003176 Dehydratase family; Region: ILVD_EDD; cl00340 446465003177 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 446465003178 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 446465003179 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 446465003180 active site 446465003181 substrate binding site [chemical binding]; other site 446465003182 FMN binding site [chemical binding]; other site 446465003183 putative catalytic residues [active] 446465003184 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465003185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465003186 DNA-binding site [nucleotide binding]; DNA binding site 446465003187 FCD domain; Region: FCD; cl11656 446465003188 citrate synthase; Provisional; Region: PRK14033 446465003189 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 446465003190 oxalacetate binding site [chemical binding]; other site 446465003191 citrylCoA binding site [chemical binding]; other site 446465003192 coenzyme A binding site [chemical binding]; other site 446465003193 catalytic triad [active] 446465003194 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 446465003195 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446465003196 tetramer interface [polypeptide binding]; other site 446465003197 active site 446465003198 Mg2+/Mn2+ binding site [ion binding]; other site 446465003199 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 446465003200 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446465003201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465003202 DNA-binding site [nucleotide binding]; DNA binding site 446465003203 FCD domain; Region: FCD; cl11656 446465003204 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 446465003205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465003206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465003207 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 446465003208 nucleotide binding site/active site [active] 446465003209 HIT family signature motif; other site 446465003210 catalytic residue [active] 446465003211 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 446465003212 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 446465003213 Protein of unknown function (DUF419); Region: DUF419; cl09948 446465003214 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 446465003215 heat shock protein GrpE; Provisional; Region: PRK14140 446465003216 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 446465003217 dimer interface [polypeptide binding]; other site 446465003218 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446465003219 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 446465003220 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 446465003221 HSP70 interaction site [polypeptide binding]; other site 446465003222 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 446465003223 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 446465003224 DNA binding residues [nucleotide binding] 446465003225 putative dimer interface [polypeptide binding]; other site 446465003226 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465003227 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446465003228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465003229 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 446465003230 putative ADP-binding pocket [chemical binding]; other site 446465003231 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 446465003232 substrate binding site [chemical binding]; other site 446465003233 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 446465003234 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465003235 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446465003236 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465003237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465003238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465003239 dimer interface [polypeptide binding]; other site 446465003240 conserved gate region; other site 446465003241 putative PBP binding loops; other site 446465003242 ABC-ATPase subunit interface; other site 446465003243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465003244 dimer interface [polypeptide binding]; other site 446465003245 conserved gate region; other site 446465003246 ABC-ATPase subunit interface; other site 446465003247 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465003248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465003250 DNA binding site [nucleotide binding] 446465003251 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465003252 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446465003253 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446465003254 active site 446465003255 HIGH motif; other site 446465003256 dimer interface [polypeptide binding]; other site 446465003257 KMSKS motif; other site 446465003258 cysteine synthases; Region: cysKM; TIGR01136 446465003259 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 446465003260 dimer interface [polypeptide binding]; other site 446465003261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465003262 catalytic residue [active] 446465003263 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 446465003264 serine O-acetyltransferase; Region: cysE; TIGR01172 446465003265 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 446465003266 trimer interface [polypeptide binding]; other site 446465003267 active site 446465003268 substrate binding site [chemical binding]; other site 446465003269 CoA binding site [chemical binding]; other site 446465003270 NAD-dependent deacetylase; Provisional; Region: PRK14138 446465003271 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2-fam; cd01407 446465003272 NAD+ binding site [chemical binding]; other site 446465003273 substrate binding site [chemical binding]; other site 446465003274 Zn binding site [ion binding]; other site 446465003275 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465003276 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465003277 active site 446465003278 catalytic tetrad [active] 446465003279 Amidinotransferase; Region: Amidinotransf; cl12043 446465003280 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 446465003281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465003282 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 446465003283 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446465003284 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 446465003285 lipoyl attachment site [posttranslational modification]; other site 446465003286 glycine dehydrogenase; Provisional; Region: PRK05367 446465003287 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 446465003288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465003289 tetramer interface [polypeptide binding]; other site 446465003290 catalytic residue [active] 446465003291 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 446465003292 tetramer interface [polypeptide binding]; other site 446465003293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465003294 catalytic residue [active] 446465003295 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 446465003296 substrate binding site [chemical binding]; other site 446465003297 THF binding site; other site 446465003298 zinc-binding site [ion binding]; other site 446465003299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465003300 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 446465003301 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 446465003302 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 446465003303 catalytic triad [active] 446465003304 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 446465003305 Protein of unknown function (DUF952); Region: DUF952; cl01393 446465003306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465003307 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446465003308 Active site [active] 446465003309 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 446465003310 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465003311 RNA binding surface [nucleotide binding]; other site 446465003312 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 446465003313 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 446465003314 Clp amino terminal domain; Region: Clp_N; pfam02861 446465003315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465003316 Walker A motif; other site 446465003317 ATP binding site [chemical binding]; other site 446465003318 Walker B motif; other site 446465003319 arginine finger; other site 446465003320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465003321 Walker A motif; other site 446465003322 ATP binding site [chemical binding]; other site 446465003323 Walker B motif; other site 446465003324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446465003325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003326 active site 446465003327 HIGH motif; other site 446465003328 nucleotide binding site [chemical binding]; other site 446465003329 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 446465003330 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003331 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003332 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003333 active site 446465003334 KMSKS motif; other site 446465003335 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 446465003336 tRNA binding surface [nucleotide binding]; other site 446465003337 Membrane transport protein; Region: Mem_trans; cl09117 446465003338 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 446465003339 tetramerization interface [polypeptide binding]; other site 446465003340 active site 446465003341 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 446465003342 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465003343 ATP binding site [chemical binding]; other site 446465003344 Mg++ binding site [ion binding]; other site 446465003345 motif III; other site 446465003346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465003347 nucleotide binding region [chemical binding]; other site 446465003348 ATP-binding site [chemical binding]; other site 446465003349 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 446465003350 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 446465003351 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 446465003352 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 446465003353 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446465003354 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446465003355 active site 446465003356 FMN binding site [chemical binding]; other site 446465003357 substrate binding site [chemical binding]; other site 446465003358 homotetramer interface [polypeptide binding]; other site 446465003359 catalytic residue [active] 446465003360 acetyl-CoA synthetase; Provisional; Region: PRK00174 446465003361 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 446465003362 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 446465003363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465003364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465003365 active site 446465003366 phosphorylation site [posttranslational modification] 446465003367 intermolecular recognition site; other site 446465003368 dimerization interface [polypeptide binding]; other site 446465003369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 446465003370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 446465003371 Histidine kinase; Region: HisKA_3; pfam07730 446465003372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465003373 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003374 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465003375 DNA binding site [nucleotide binding] 446465003376 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465003377 dimerization interface [polypeptide binding]; other site 446465003378 ligand binding site [chemical binding]; other site 446465003379 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 446465003380 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003381 active site 446465003382 HIGH motif; other site 446465003383 nucleotide binding site [chemical binding]; other site 446465003384 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 446465003385 KMSKS motif; other site 446465003386 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446465003387 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 446465003388 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 446465003389 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446465003390 Predicted membrane protein [Function unknown]; Region: COG2364 446465003391 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446465003392 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 446465003393 Walker A/P-loop; other site 446465003394 ATP binding site [chemical binding]; other site 446465003395 Q-loop/lid; other site 446465003396 ABC transporter signature motif; other site 446465003397 Walker B; other site 446465003398 D-loop; other site 446465003399 H-loop/switch region; other site 446465003400 TOBE domain; Region: TOBE_2; cl01440 446465003401 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 446465003402 active site 446465003403 catalytic residues [active] 446465003404 metal binding site [ion binding]; metal-binding site 446465003405 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 446465003406 dimer interface [polypeptide binding]; other site 446465003407 substrate binding site [chemical binding]; other site 446465003408 metal binding sites [ion binding]; metal-binding site 446465003409 Beta-lactamase; Region: Beta-lactamase; cl01009 446465003410 PBP4 family; Region: PBP4; TIGR00666 446465003411 Beta-lactamase; Region: Beta-lactamase; cl01009 446465003412 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 446465003413 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465003414 FtsH Extracellular; Region: FtsH_ext; pfam06480 446465003415 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 446465003416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465003417 Walker A motif; other site 446465003418 ATP binding site [chemical binding]; other site 446465003419 Walker B motif; other site 446465003420 arginine finger; other site 446465003421 Peptidase family M41; Region: Peptidase_M41; pfam01434 446465003422 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 446465003423 homodecamer interface [polypeptide binding]; other site 446465003424 GTP cyclohydrolase I; Provisional; Region: PLN03044 446465003425 active site 446465003426 putative catalytic site residues [active] 446465003427 zinc binding site [ion binding]; other site 446465003428 GTP-CH-I/GFRP interaction surface; other site 446465003429 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 446465003430 dihydropteroate synthase; Region: DHPS; TIGR01496 446465003431 substrate binding pocket [chemical binding]; other site 446465003432 dimer interface [polypeptide binding]; other site 446465003433 inhibitor binding site; inhibition site 446465003434 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 446465003435 homooctamer interface [polypeptide binding]; other site 446465003436 active site 446465003437 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 446465003438 catalytic center binding site [active] 446465003439 ATP binding site [chemical binding]; other site 446465003440 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 446465003441 Bacterial membrane flanked domain; Region: DUF304; cl01348 446465003442 Predicted membrane protein [Function unknown]; Region: COG3428 446465003443 Bacterial membrane flanked domain; Region: DUF304; cl01348 446465003444 Bacterial membrane flanked domain; Region: DUF304; cl01348 446465003445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465003446 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 446465003447 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003448 active site 446465003449 nucleotide binding site [chemical binding]; other site 446465003450 HIGH motif; other site 446465003451 KMSKS motif; other site 446465003452 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 446465003453 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 446465003454 dimer interface [polypeptide binding]; other site 446465003455 putative anticodon binding site; other site 446465003456 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446465003457 motif 1; other site 446465003458 dimer interface [polypeptide binding]; other site 446465003459 active site 446465003460 motif 2; other site 446465003461 motif 3; other site 446465003462 Lsr2; Region: Lsr2; pfam11774 446465003463 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 446465003464 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 446465003465 active site 446465003466 catalytic residues [active] 446465003467 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 446465003468 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 446465003469 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 446465003470 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446465003471 Cysteine-rich domain; Region: CCG; pfam02754 446465003472 Cysteine-rich domain; Region: CCG; pfam02754 446465003473 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 446465003474 Predicted dehydrogenase [General function prediction only]; Region: COG0579 446465003475 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 446465003476 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 446465003477 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465003478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465003479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465003480 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 446465003481 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465003482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465003483 DNA-binding site [nucleotide binding]; DNA binding site 446465003484 FCD domain; Region: FCD; cl11656 446465003485 Clp protease ATP binding subunit; Region: clpC; CHL00095 446465003486 Clp amino terminal domain; Region: Clp_N; pfam02861 446465003487 Clp amino terminal domain; Region: Clp_N; pfam02861 446465003488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465003489 Walker A motif; other site 446465003490 ATP binding site [chemical binding]; other site 446465003491 Walker B motif; other site 446465003492 arginine finger; other site 446465003493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465003494 Walker A motif; other site 446465003495 ATP binding site [chemical binding]; other site 446465003496 Walker B motif; other site 446465003497 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446465003498 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446465003499 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 446465003500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465003501 Coenzyme A binding pocket [chemical binding]; other site 446465003502 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 446465003503 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446465003504 minor groove reading motif; other site 446465003505 helix-hairpin-helix signature motif; other site 446465003506 substrate binding pocket [chemical binding]; other site 446465003507 active site 446465003508 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 446465003509 SAF domain; Region: SAF; cl00555 446465003510 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 446465003511 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 446465003512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465003513 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446465003514 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446465003515 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465003516 catalytic residue [active] 446465003517 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446465003518 FAD binding domain; Region: FAD_binding_4; pfam01565 446465003519 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 446465003520 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 446465003521 active site 446465003522 dimerization interface [polypeptide binding]; other site 446465003523 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003524 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465003525 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446465003526 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465003527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465003528 dimerization interface [polypeptide binding]; other site 446465003529 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 446465003530 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 446465003531 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446465003532 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 446465003533 Predicted methyltransferases [General function prediction only]; Region: COG0313 446465003534 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 446465003535 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 446465003536 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 446465003537 active site 446465003538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465003539 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 446465003540 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 446465003541 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 446465003542 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446465003543 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 446465003544 ABC transporter; Region: ABC_tran_2; pfam12848 446465003545 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 446465003546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465003547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465003548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465003549 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 446465003550 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 446465003551 Substrate binding site [chemical binding]; other site 446465003552 Mg++ binding site [ion binding]; other site 446465003553 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 446465003554 active site 446465003555 substrate binding site [chemical binding]; other site 446465003556 CoA binding site [chemical binding]; other site 446465003557 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 446465003558 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465003559 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 446465003560 5S rRNA interface [nucleotide binding]; other site 446465003561 CTC domain interface; other site 446465003562 L16 interface [polypeptide binding]; other site 446465003563 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 446465003564 putative active site [active] 446465003565 catalytic residue [active] 446465003566 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 446465003567 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 446465003568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465003569 ATP binding site [chemical binding]; other site 446465003570 putative Mg++ binding site [ion binding]; other site 446465003571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465003572 nucleotide binding region [chemical binding]; other site 446465003573 ATP-binding site [chemical binding]; other site 446465003574 TRCF domain; Region: TRCF; pfam03461 446465003575 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 446465003576 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 446465003577 enolase; Provisional; Region: eno; PRK00077 446465003578 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 446465003579 dimer interface [polypeptide binding]; other site 446465003580 metal binding site [ion binding]; metal-binding site 446465003581 substrate binding pocket [chemical binding]; other site 446465003582 Septum formation initiator; Region: DivIC; cl11433 446465003583 Protein of unknown function (DUF501); Region: DUF501; cl00652 446465003584 exopolyphosphatase; Region: exo_poly_only; TIGR03706 446465003585 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 446465003586 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446465003587 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 446465003588 active site 446465003589 trimer interface [polypeptide binding]; other site 446465003590 allosteric site; other site 446465003591 active site lid [active] 446465003592 Sulfate transporter family; Region: Sulfate_transp; cl00967 446465003593 Permease family; Region: Xan_ur_permease; pfam00860 446465003594 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446465003595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465003596 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446465003597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465003598 catalytic residue [active] 446465003599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465003600 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 446465003601 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465003602 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 446465003603 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465003604 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465003605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465003606 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465003607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465003608 dimer interface [polypeptide binding]; other site 446465003609 conserved gate region; other site 446465003610 putative PBP binding loops; other site 446465003611 ABC-ATPase subunit interface; other site 446465003612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465003614 DNA binding site [nucleotide binding] 446465003615 domain linker motif; other site 446465003616 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465003617 ligand binding site [chemical binding]; other site 446465003618 dimerization interface [polypeptide binding]; other site 446465003619 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 446465003620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465003621 motif I; other site 446465003622 motif II; other site 446465003623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465003624 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 446465003625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465003626 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 446465003627 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 446465003628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465003629 Walker A/P-loop; other site 446465003630 ATP binding site [chemical binding]; other site 446465003631 Q-loop/lid; other site 446465003632 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 446465003633 ABC transporter signature motif; other site 446465003634 Walker B; other site 446465003635 D-loop; other site 446465003636 H-loop/switch region; other site 446465003637 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 446465003638 Thiamine pyrophosphokinase; Region: TPK; cl09135 446465003639 active site 446465003640 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 446465003641 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 446465003642 integral membrane protein MviN; Region: mviN; TIGR01695 446465003643 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465003644 CTP synthetase; Validated; Region: pyrG; PRK05380 446465003645 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 446465003646 Catalytic site [active] 446465003647 Active site [active] 446465003648 UTP binding site [chemical binding]; other site 446465003649 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 446465003650 active site 446465003651 putative oxyanion hole; other site 446465003652 catalytic triad [active] 446465003653 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 446465003654 dimer interface [polypeptide binding]; other site 446465003655 active site 446465003656 ADP-ribose binding site [chemical binding]; other site 446465003657 nudix motif; other site 446465003658 metal binding site [ion binding]; metal-binding site 446465003659 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 446465003660 putative active site [active] 446465003661 putative substrate binding site [chemical binding]; other site 446465003662 catalytic site [active] 446465003663 HRDC domain; Region: HRDC; cl02578 446465003664 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 446465003665 SelR domain; Region: SelR; cl00369 446465003666 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465003667 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465003668 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 446465003669 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 446465003670 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 446465003671 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 446465003672 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465003673 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446465003674 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 446465003675 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465003676 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446465003677 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 446465003678 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465003679 GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735 446465003680 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 446465003681 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 446465003682 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 446465003683 active site 446465003684 dimer interface [polypeptide binding]; other site 446465003685 motif 1; other site 446465003686 motif 2; other site 446465003687 motif 3; other site 446465003688 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 446465003689 anticodon binding site; other site 446465003690 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 446465003691 nucleotide binding site/active site [active] 446465003692 HIT family signature motif; other site 446465003693 catalytic residue [active] 446465003694 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 446465003695 Domain of unknown function DUF28; Region: DUF28; cl00361 446465003696 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 446465003697 active site 446465003698 putative DNA-binding cleft [nucleotide binding]; other site 446465003699 dimer interface [polypeptide binding]; other site 446465003700 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 446465003701 RuvA N terminal domain; Region: RuvA_N; pfam01330 446465003702 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 446465003703 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 446465003704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465003705 Walker A motif; other site 446465003706 ATP binding site [chemical binding]; other site 446465003707 Walker B motif; other site 446465003708 arginine finger; other site 446465003709 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 446465003710 Preprotein translocase subunit; Region: YajC; cl00806 446465003711 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 446465003712 Protein export membrane protein; Region: SecD_SecF; cl14618 446465003713 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 446465003714 Protein export membrane protein; Region: SecD_SecF; cl14618 446465003715 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465003716 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446465003717 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 446465003718 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446465003719 synthetase active site [active] 446465003720 NTP binding site [chemical binding]; other site 446465003721 metal binding site [ion binding]; metal-binding site 446465003722 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 446465003723 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 446465003724 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446465003725 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446465003726 histidyl-tRNA synthetase; Region: hisS; TIGR00442 446465003727 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 446465003728 dimer interface [polypeptide binding]; other site 446465003729 motif 1; other site 446465003730 active site 446465003731 motif 2; other site 446465003732 motif 3; other site 446465003733 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 446465003734 anticodon binding site; other site 446465003735 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446465003736 catalytic residues [active] 446465003737 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 446465003738 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 446465003739 ATP binding site [chemical binding]; other site 446465003740 Mg++ binding site [ion binding]; other site 446465003741 motif III; other site 446465003742 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465003743 nucleotide binding region [chemical binding]; other site 446465003744 ATP-binding site [chemical binding]; other site 446465003745 DbpA RNA binding domain; Region: DbpA; pfam03880 446465003746 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 446465003747 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 446465003748 dimer interface [polypeptide binding]; other site 446465003749 anticodon binding site; other site 446465003750 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 446465003751 homodimer interface [polypeptide binding]; other site 446465003752 motif 1; other site 446465003753 active site 446465003754 motif 2; other site 446465003755 GAD domain; Region: GAD; pfam02938 446465003756 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446465003757 active site 446465003758 motif 3; other site 446465003759 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 446465003760 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 446465003761 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 446465003762 active site 446465003763 metal binding site [ion binding]; metal-binding site 446465003764 dimer interface [polypeptide binding]; other site 446465003765 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 446465003766 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 446465003767 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446465003768 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446465003769 D-pathway; other site 446465003770 Putative ubiquinol binding site [chemical binding]; other site 446465003771 Low-spin heme (heme b) binding site [chemical binding]; other site 446465003772 Putative water exit pathway; other site 446465003773 Binuclear center (heme o3/CuB) [ion binding]; other site 446465003774 K-pathway; other site 446465003775 Putative proton exit pathway; other site 446465003776 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 446465003777 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 446465003778 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 446465003779 heme bH binding site [chemical binding]; other site 446465003780 intrachain domain interface; other site 446465003781 heme bL binding site [chemical binding]; other site 446465003782 interchain domain interface [polypeptide binding]; other site 446465003783 Qo binding site; other site 446465003784 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 446465003785 iron-sulfur cluster [ion binding]; other site 446465003786 [2Fe-2S] cluster binding site [ion binding]; other site 446465003787 Cytochrome c; Region: Cytochrom_C; cl11414 446465003788 Cytochrome c; Region: Cytochrom_C; cl11414 446465003789 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 446465003790 Subunit I/III interface [polypeptide binding]; other site 446465003791 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 446465003792 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446465003793 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446465003794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465003795 hypothetical protein; Validated; Region: PRK07883 446465003796 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446465003797 active site 446465003798 substrate binding site [chemical binding]; other site 446465003799 catalytic site [active] 446465003800 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 446465003801 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446465003802 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 446465003803 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446465003804 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465003805 Esterase/lipase [General function prediction only]; Region: COG1647 446465003806 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446465003807 putative acyl-acceptor binding pocket; other site 446465003808 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 446465003809 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465003810 active site 446465003811 ATP binding site [chemical binding]; other site 446465003812 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465003813 substrate binding site [chemical binding]; other site 446465003814 activation loop (A-loop); other site 446465003815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 446465003816 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 446465003817 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 446465003818 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 446465003819 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446465003820 substrate binding pocket [chemical binding]; other site 446465003821 chain length determination region; other site 446465003822 substrate-Mg2+ binding site; other site 446465003823 catalytic residues [active] 446465003824 aspartate-rich region 1; other site 446465003825 active site lid residues [active] 446465003826 aspartate-rich region 2; other site 446465003827 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465003828 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 446465003829 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446465003830 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446465003831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446465003832 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446465003833 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 446465003834 DNA binding residues [nucleotide binding] 446465003835 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446465003836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465003837 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 446465003838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465003839 ATP binding site [chemical binding]; other site 446465003840 Mg2+ binding site [ion binding]; other site 446465003841 G-X-G motif; other site 446465003842 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 446465003843 anchoring element; other site 446465003844 dimer interface [polypeptide binding]; other site 446465003845 ATP binding site [chemical binding]; other site 446465003846 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 446465003847 active site 446465003848 metal binding site [ion binding]; metal-binding site 446465003849 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446465003850 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 446465003851 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 446465003852 substrate binding site [chemical binding]; other site 446465003853 glutamase interaction surface [polypeptide binding]; other site 446465003854 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 446465003855 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 446465003856 active site 446465003857 phosphate binding residues; other site 446465003858 catalytic residues [active] 446465003859 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 446465003860 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 446465003861 CAP-like domain; other site 446465003862 Active site [active] 446465003863 primary dimer interface [polypeptide binding]; other site 446465003864 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465003865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465003866 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 446465003867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465003868 urea carboxylase; Region: urea_carbox; TIGR02712 446465003869 Sulfatase; Region: Sulfatase; cl10460 446465003870 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 446465003871 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 446465003872 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446465003873 trimer interface [polypeptide binding]; other site 446465003874 active site 446465003875 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 446465003876 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446465003877 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 446465003878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465003879 aconitate hydratase; Validated; Region: PRK09277 446465003880 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446465003881 substrate binding site [chemical binding]; other site 446465003882 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446465003883 ligand binding site [chemical binding]; other site 446465003884 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 446465003885 substrate binding site [chemical binding]; other site 446465003886 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446465003887 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 446465003888 TPP-binding site [chemical binding]; other site 446465003889 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446465003890 PYR/PP interface [polypeptide binding]; other site 446465003891 dimer interface [polypeptide binding]; other site 446465003892 TPP binding site [chemical binding]; other site 446465003893 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465003894 methionine aminopeptidase; Reviewed; Region: PRK07281 446465003895 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446465003896 active site 446465003897 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446465003898 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446465003899 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 446465003900 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446465003901 Walker A/P-loop; other site 446465003902 ATP binding site [chemical binding]; other site 446465003903 Q-loop/lid; other site 446465003904 ABC transporter signature motif; other site 446465003905 Walker B; other site 446465003906 D-loop; other site 446465003907 H-loop/switch region; other site 446465003908 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 446465003909 GST_C family, ECM4-like subfamily; composed of predominantly uncharacterized and taxonomically diverse proteins with similarity to the translation product of the Saccharomyces cerevisiae gene ECM4. ECM4, a gene of unknown function, is involved in cell...; Region: GST_C_ECM4_like; cd03190 446465003910 Predicted transcriptional regulator [Transcription]; Region: COG2345 446465003911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465003912 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 446465003913 FeS assembly protein SufB; Region: sufB; TIGR01980 446465003914 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 446465003915 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 446465003916 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 446465003917 [2Fe-2S] cluster binding site [ion binding]; other site 446465003918 FeS assembly ATPase SufC; Region: sufC; TIGR01978 446465003919 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 446465003920 Walker A/P-loop; other site 446465003921 ATP binding site [chemical binding]; other site 446465003922 Q-loop/lid; other site 446465003923 ABC transporter signature motif; other site 446465003924 Walker B; other site 446465003925 D-loop; other site 446465003926 H-loop/switch region; other site 446465003927 Domain of unknown function DUF59; Region: DUF59; cl00941 446465003928 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446465003929 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 446465003930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465003931 NAD(P) binding pocket [chemical binding]; other site 446465003932 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446465003933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465003934 Walker A/P-loop; other site 446465003935 ATP binding site [chemical binding]; other site 446465003936 Q-loop/lid; other site 446465003937 ABC transporter signature motif; other site 446465003938 Walker B; other site 446465003939 D-loop; other site 446465003940 H-loop/switch region; other site 446465003941 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 446465003942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465003943 elongation factor P; Validated; Region: PRK00529 446465003944 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 446465003945 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 446465003946 RNA binding site [nucleotide binding]; other site 446465003947 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 446465003948 RNA binding site [nucleotide binding]; other site 446465003949 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 446465003950 putative RNA binding site [nucleotide binding]; other site 446465003951 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465003952 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 446465003953 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446465003954 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446465003955 dihydroorotase; Validated; Region: pyrC; PRK09357 446465003956 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465003957 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 446465003958 active site 446465003959 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 446465003960 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 446465003961 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 446465003962 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 446465003963 catalytic site [active] 446465003964 subunit interface [polypeptide binding]; other site 446465003965 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 446465003966 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446465003967 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465003968 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 446465003969 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446465003970 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465003971 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 446465003972 IMP binding site; other site 446465003973 dimer interface [polypeptide binding]; other site 446465003974 interdomain contacts; other site 446465003975 partial ornithine binding site; other site 446465003976 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 446465003977 active site 446465003978 dimer interface [polypeptide binding]; other site 446465003979 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 446465003980 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 446465003981 catalytic site [active] 446465003982 G-X2-G-X-G-K; other site 446465003983 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 446465003984 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 446465003985 Flavoprotein; Region: Flavoprotein; cl08021 446465003986 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 446465003987 S-adenosylmethionine synthetase; Validated; Region: PRK05250 446465003988 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 446465003989 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 446465003990 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 446465003991 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 446465003992 anthranilate synthase component I; Provisional; Region: PRK13571 446465003993 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446465003994 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446465003995 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 446465003996 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 446465003997 active site 446465003998 ribulose/triose binding site [chemical binding]; other site 446465003999 substrate (anthranilate) binding pocket [chemical binding]; other site 446465004000 product (indole) binding pocket [chemical binding]; other site 446465004001 tryptophan synthase, beta chain; Region: PLN02618 446465004002 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 446465004003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465004004 catalytic residue [active] 446465004005 tryptophan synthase; Region: PLN02591 446465004006 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 446465004007 substrate binding site [chemical binding]; other site 446465004008 active site 446465004009 catalytic residues [active] 446465004010 heterodimer interface [polypeptide binding]; other site 446465004011 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 446465004012 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 446465004013 pyruvate kinase; Provisional; Region: PRK06247 446465004014 domain interfaces; other site 446465004015 active site 446465004016 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 446465004017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465004018 active site 446465004019 phosphorylation site [posttranslational modification] 446465004020 intermolecular recognition site; other site 446465004021 dimerization interface [polypeptide binding]; other site 446465004022 ANTAR domain; Region: ANTAR; pfam03861 446465004023 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 446465004024 ligand binding site [chemical binding]; other site 446465004025 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446465004026 CoenzymeA binding site [chemical binding]; other site 446465004027 subunit interaction site [polypeptide binding]; other site 446465004028 PHB binding site; other site 446465004029 DNA polymerase I; Provisional; Region: PRK05755 446465004030 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446465004031 active site 446465004032 metal binding site 1 [ion binding]; metal-binding site 446465004033 putative 5' ssDNA interaction site; other site 446465004034 metal binding site 3; metal-binding site 446465004035 metal binding site 2 [ion binding]; metal-binding site 446465004036 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446465004037 putative DNA binding site [nucleotide binding]; other site 446465004038 putative metal binding site [ion binding]; other site 446465004039 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 446465004040 active site 446465004041 DNA binding site [nucleotide binding] 446465004042 catalytic site [active] 446465004043 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 446465004044 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 446465004045 RNA binding site [nucleotide binding]; other site 446465004046 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 446465004047 RNA binding site [nucleotide binding]; other site 446465004048 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 446465004049 RNA binding site [nucleotide binding]; other site 446465004050 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 446465004051 RNA binding site [nucleotide binding]; other site 446465004052 UMP phosphatase; Provisional; Region: PRK10444 446465004053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465004054 active site 446465004055 motif I; other site 446465004056 motif II; other site 446465004057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465004058 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 446465004059 Tetramer interface [polypeptide binding]; other site 446465004060 Active site [active] 446465004061 FMN-binding site [chemical binding]; other site 446465004062 shikimate kinase; Reviewed; Region: aroK; PRK00131 446465004063 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 446465004064 ADP binding site [chemical binding]; other site 446465004065 magnesium binding site [ion binding]; other site 446465004066 putative shikimate binding site; other site 446465004067 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446465004068 active site 446465004069 dimer interface [polypeptide binding]; other site 446465004070 metal binding site [ion binding]; metal-binding site 446465004071 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 446465004072 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 446465004073 active site 446465004074 catalytic residue [active] 446465004075 dimer interface [polypeptide binding]; other site 446465004076 UPF0126 domain; Region: UPF0126; pfam03458 446465004077 UPF0126 domain; Region: UPF0126; pfam03458 446465004078 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 446465004079 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 446465004080 CoA-binding site [chemical binding]; other site 446465004081 ATP-binding [chemical binding]; other site 446465004082 excinuclease ABC subunit B; Provisional; Region: PRK05298 446465004083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 446465004084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465004085 nucleotide binding region [chemical binding]; other site 446465004086 ATP-binding site [chemical binding]; other site 446465004087 Ultra-violet resistance protein B; Region: UvrB; pfam12344 446465004088 UvrB/uvrC motif; Region: UVR; pfam02151 446465004089 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465004090 nudix motif; other site 446465004091 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 446465004092 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 446465004093 active site 446465004094 DNA binding site [nucleotide binding] 446465004095 catalytic site [active] 446465004096 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465004097 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 446465004098 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 446465004099 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 446465004100 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 446465004101 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 446465004102 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 446465004103 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 446465004104 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 446465004105 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 446465004106 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 446465004107 putative substrate binding pocket [chemical binding]; other site 446465004108 dimer interface [polypeptide binding]; other site 446465004109 phosphate binding site [ion binding]; other site 446465004110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 446465004111 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 446465004112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465004113 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 446465004114 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 446465004115 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 446465004116 substrate binding site [chemical binding]; other site 446465004117 hinge regions; other site 446465004118 ADP binding site [chemical binding]; other site 446465004119 catalytic site [active] 446465004120 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446465004121 substrate binding site [chemical binding]; other site 446465004122 dimer interface [polypeptide binding]; other site 446465004123 catalytic triad [active] 446465004124 opcA protein; Region: OpcA; TIGR00534 446465004125 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 446465004126 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 446465004127 putative active site [active] 446465004128 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 446465004129 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446465004130 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446465004131 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 446465004132 putative active site [active] 446465004133 transaldolase; Provisional; Region: PRK03903 446465004134 catalytic residue [active] 446465004135 transketolase; Reviewed; Region: PRK05899 446465004136 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446465004137 TPP-binding site [chemical binding]; other site 446465004138 dimer interface [polypeptide binding]; other site 446465004139 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446465004140 PYR/PP interface [polypeptide binding]; other site 446465004141 dimer interface [polypeptide binding]; other site 446465004142 TPP binding site [chemical binding]; other site 446465004143 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465004144 UbiA prenyltransferase family; Region: UbiA; cl00337 446465004145 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 446465004146 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446465004147 DNA binding site [nucleotide binding] 446465004148 Int/Topo IB signature motif; other site 446465004149 active site 446465004150 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446465004151 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 446465004152 P-loop; other site 446465004153 Magnesium ion binding site [ion binding]; other site 446465004154 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 446465004155 Magnesium ion binding site [ion binding]; other site 446465004156 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 446465004157 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465004158 RNA binding surface [nucleotide binding]; other site 446465004159 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 446465004160 active site 446465004161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465004162 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446465004163 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 446465004164 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 446465004165 CMP-binding site; other site 446465004166 The sites determining sugar specificity; other site 446465004167 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 446465004168 G1 box; other site 446465004169 GTP/Mg2+ binding site [chemical binding]; other site 446465004170 Switch I region; other site 446465004171 G2 box; other site 446465004172 Switch II region; other site 446465004173 G3 box; other site 446465004174 G4 box; other site 446465004175 G5 box; other site 446465004176 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 446465004177 G1 box; other site 446465004178 GTP/Mg2+ binding site [chemical binding]; other site 446465004179 Switch I region; other site 446465004180 G2 box; other site 446465004181 G3 box; other site 446465004182 Switch II region; other site 446465004183 G4 box; other site 446465004184 G5 box; other site 446465004185 TM2 domain; Region: TM2; cl00984 446465004186 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465004187 nudix motif; other site 446465004188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465004189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465004190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004191 dimer interface [polypeptide binding]; other site 446465004192 conserved gate region; other site 446465004193 putative PBP binding loops; other site 446465004194 ABC-ATPase subunit interface; other site 446465004195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465004196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004197 dimer interface [polypeptide binding]; other site 446465004198 conserved gate region; other site 446465004199 putative PBP binding loops; other site 446465004200 ABC-ATPase subunit interface; other site 446465004201 short chain dehydrogenase; Provisional; Region: PRK06701 446465004202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465004203 NAD(P) binding site [chemical binding]; other site 446465004204 active site 446465004205 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 446465004206 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 446465004207 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 446465004208 active site 446465004209 substrate binding site [chemical binding]; other site 446465004210 cosubstrate binding site; other site 446465004211 catalytic site [active] 446465004212 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446465004213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465004214 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 446465004215 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 446465004216 inhibitor-cofactor binding pocket; inhibition site 446465004217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465004218 catalytic residue [active] 446465004219 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 446465004220 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 446465004221 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 446465004222 active site 446465004223 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465004224 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 446465004225 NAD(P) binding site [chemical binding]; other site 446465004226 catalytic residues [active] 446465004227 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446465004228 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 446465004229 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446465004230 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465004231 phosphopeptide binding site; other site 446465004232 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446465004233 DNA binding residues [nucleotide binding] 446465004234 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 446465004235 DNA binding residues [nucleotide binding] 446465004236 putative dimer interface [polypeptide binding]; other site 446465004237 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446465004238 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 446465004239 P loop; other site 446465004240 Nucleotide binding site [chemical binding]; other site 446465004241 DTAP/Switch II; other site 446465004242 Switch I; other site 446465004243 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 446465004244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465004245 TIGR03085 family protein; Region: TIGR03085 446465004246 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465004247 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 446465004248 AP (apurinic/apyrimidinic) site pocket; other site 446465004249 DNA interaction; other site 446465004250 Metal-binding active site; metal-binding site 446465004251 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 446465004252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465004253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465004254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465004255 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 446465004256 PAC2 family; Region: PAC2; cl00847 446465004257 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 446465004258 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446465004259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465004260 motif II; other site 446465004261 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 446465004262 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446465004263 Walker A/P-loop; other site 446465004264 ATP binding site [chemical binding]; other site 446465004265 Q-loop/lid; other site 446465004266 ABC transporter signature motif; other site 446465004267 Walker B; other site 446465004268 D-loop; other site 446465004269 H-loop/switch region; other site 446465004270 glycogen branching enzyme; Provisional; Region: PRK14705 446465004271 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 446465004272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465004273 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 446465004274 putative substrate translocation pore; other site 446465004275 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 446465004276 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 446465004277 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 446465004278 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446465004279 active site 446465004280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465004281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465004282 MMPL family; Region: MMPL; pfam03176 446465004283 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446465004284 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446465004285 Predicted membrane protein [Function unknown]; Region: COG1511 446465004286 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 446465004287 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 446465004288 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 446465004289 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 446465004290 generic binding surface II; other site 446465004291 generic binding surface I; other site 446465004292 DNA Polymerase Y-family; Region: PolY_like; cd03468 446465004293 DNA binding site [nucleotide binding] 446465004294 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 446465004295 active site 446465004296 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465004297 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 446465004298 inhibitor binding site; inhibition site 446465004299 catalytic Zn binding site [ion binding]; other site 446465004300 structural Zn binding site [ion binding]; other site 446465004301 NADP binding site [chemical binding]; other site 446465004302 tetramer interface [polypeptide binding]; other site 446465004303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465004304 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446465004305 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446465004306 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446465004307 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465004308 Walker A/P-loop; other site 446465004309 ATP binding site [chemical binding]; other site 446465004310 Q-loop/lid; other site 446465004311 ABC transporter signature motif; other site 446465004312 Walker B; other site 446465004313 D-loop; other site 446465004314 H-loop/switch region; other site 446465004315 RNB domain; Region: RNB; pfam00773 446465004316 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 446465004317 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446465004318 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 446465004319 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 446465004320 ligand binding site [chemical binding]; other site 446465004321 oligomer interface [polypeptide binding]; other site 446465004322 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 446465004323 sulfate 1 binding site; other site 446465004324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465004325 motif II; other site 446465004326 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465004327 catalytic core [active] 446465004328 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 446465004329 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446465004330 NAD(P) binding site [chemical binding]; other site 446465004331 homotetramer interface [polypeptide binding]; other site 446465004332 homodimer interface [polypeptide binding]; other site 446465004333 active site 446465004334 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446465004335 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 446465004336 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 446465004337 putative active site [active] 446465004338 catalytic site [active] 446465004339 putative metal binding site [ion binding]; other site 446465004340 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 446465004341 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 446465004342 Ligand binding site [chemical binding]; other site 446465004343 Putative Catalytic site [active] 446465004344 DXD motif; other site 446465004345 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 446465004346 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 446465004347 putative active site [active] 446465004348 catalytic triad [active] 446465004349 putative dimer interface [polypeptide binding]; other site 446465004350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465004351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465004352 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465004353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465004354 ATP binding site [chemical binding]; other site 446465004355 putative Mg++ binding site [ion binding]; other site 446465004356 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 446465004357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465004358 nucleotide binding region [chemical binding]; other site 446465004359 ATP-binding site [chemical binding]; other site 446465004360 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 446465004361 diacylglycerol kinase; Reviewed; Region: PRK11914 446465004362 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 446465004363 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 446465004364 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446465004365 Predicted transcriptional regulator [Transcription]; Region: COG2378 446465004366 Predicted transcriptional regulator [Transcription]; Region: COG2378 446465004367 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 446465004368 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446465004369 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 446465004370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465004371 HisG, C-terminal domain; Region: HisG_C; cl06867 446465004372 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 446465004373 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 446465004374 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 446465004375 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 446465004376 substrate binding site [chemical binding]; other site 446465004377 hexamer interface [polypeptide binding]; other site 446465004378 metal binding site [ion binding]; metal-binding site 446465004379 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 446465004380 16S rRNA methyltransferase B; Provisional; Region: PRK14902 446465004381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465004382 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 446465004383 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 446465004384 putative active site [active] 446465004385 substrate binding site [chemical binding]; other site 446465004386 putative cosubstrate binding site; other site 446465004387 catalytic site [active] 446465004388 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446465004389 substrate binding site [chemical binding]; other site 446465004390 primosome assembly protein PriA; Provisional; Region: PRK14873 446465004391 primosome assembly protein PriA; Provisional; Region: PRK14873 446465004392 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 446465004393 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 446465004394 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 446465004395 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 446465004396 Pup-like protein; Region: Pup; cl05289 446465004397 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 446465004398 Pup-ligase protein; Region: Pup_ligase; pfam03136 446465004399 proteasome ATPase; Region: pup_AAA; TIGR03689 446465004400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465004401 Walker A motif; other site 446465004402 ATP binding site [chemical binding]; other site 446465004403 Walker B motif; other site 446465004404 arginine finger; other site 446465004405 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 446465004406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465004407 S-adenosylmethionine binding site [chemical binding]; other site 446465004408 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 446465004409 active site 446465004410 putative substrate binding region [chemical binding]; other site 446465004411 PAC2 family; Region: PAC2; cl00847 446465004412 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465004413 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 446465004414 active site 446465004415 HIGH motif; other site 446465004416 nucleotide binding site [chemical binding]; other site 446465004417 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465004418 active site 446465004419 KMSKS motif; other site 446465004420 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446465004421 tRNA binding surface [nucleotide binding]; other site 446465004422 anticodon binding site; other site 446465004423 Bacitracin resistance protein BacA; Region: BacA; cl00858 446465004424 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446465004425 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446465004426 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446465004427 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 446465004428 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 446465004429 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 446465004430 shikimate binding site; other site 446465004431 NAD(P) binding site [chemical binding]; other site 446465004432 YceG-like family; Region: YceG; pfam02618 446465004433 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 446465004434 dimerization interface [polypeptide binding]; other site 446465004435 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 446465004436 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 446465004437 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 446465004438 motif 1; other site 446465004439 active site 446465004440 motif 2; other site 446465004441 motif 3; other site 446465004442 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 446465004443 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 446465004444 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 446465004445 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465004446 RNA binding surface [nucleotide binding]; other site 446465004447 recombination factor protein RarA; Reviewed; Region: PRK13342 446465004448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465004449 Walker A motif; other site 446465004450 ATP binding site [chemical binding]; other site 446465004451 Walker B motif; other site 446465004452 arginine finger; other site 446465004453 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 446465004454 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 446465004455 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 446465004456 active site 446465004457 catalytic residues [active] 446465004458 FMN binding site [chemical binding]; other site 446465004459 quinone interaction residues [chemical binding]; other site 446465004460 substrate binding site [chemical binding]; other site 446465004461 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446465004462 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 446465004463 interface (dimer of trimers) [polypeptide binding]; other site 446465004464 Substrate-binding/catalytic site; other site 446465004465 Zn-binding sites [ion binding]; other site 446465004466 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 446465004467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465004468 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446465004469 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446465004470 E3 interaction surface; other site 446465004471 lipoyl attachment site [posttranslational modification]; other site 446465004472 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446465004473 E3 interaction surface; other site 446465004474 lipoyl attachment site [posttranslational modification]; other site 446465004475 e3 binding domain; Region: E3_binding; pfam02817 446465004476 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446465004477 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446465004478 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446465004479 lipoyl synthase; Provisional; Region: PRK05481 446465004480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 446465004481 RDD family; Region: RDD; cl00746 446465004482 glutamine synthetase, type I; Region: GlnA; TIGR00653 446465004483 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446465004484 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446465004485 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 446465004486 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446465004487 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446465004488 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446465004489 Walker A/P-loop; other site 446465004490 ATP binding site [chemical binding]; other site 446465004491 Q-loop/lid; other site 446465004492 ABC transporter signature motif; other site 446465004493 Walker B; other site 446465004494 D-loop; other site 446465004495 H-loop/switch region; other site 446465004496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465004497 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 446465004498 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446465004499 metal binding triad; other site 446465004500 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446465004501 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446465004502 metal binding triad; other site 446465004503 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446465004504 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446465004505 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446465004506 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446465004507 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 446465004508 oligomerization interface [polypeptide binding]; other site 446465004509 active site 446465004510 metal binding site [ion binding]; metal-binding site 446465004511 methionine aminopeptidase; Provisional; Region: PRK12318 446465004512 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446465004513 active site 446465004514 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465004515 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465004516 Protein of unknown function (DUF328); Region: DUF328; cl01143 446465004517 Uncharacterized conserved protein [Function unknown]; Region: COG0327 446465004518 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 446465004519 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 446465004520 trimerization site [polypeptide binding]; other site 446465004521 active site 446465004522 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446465004523 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 446465004524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465004525 catalytic residue [active] 446465004526 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 446465004527 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 446465004528 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 446465004529 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 446465004530 dimer interface [polypeptide binding]; other site 446465004531 TPP-binding site [chemical binding]; other site 446465004532 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446465004533 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446465004534 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446465004535 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446465004536 dimer interface [polypeptide binding]; other site 446465004537 active site 446465004538 CoA binding pocket [chemical binding]; other site 446465004539 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446465004540 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446465004541 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446465004542 dimer interface [polypeptide binding]; other site 446465004543 active site 446465004544 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 446465004545 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 446465004546 active site 446465004547 catalytic residues [active] 446465004548 metal binding site [ion binding]; metal-binding site 446465004549 OsmC-like protein; Region: OsmC; cl00767 446465004550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465004551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465004552 DNA binding site [nucleotide binding] 446465004553 domain linker motif; other site 446465004554 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465004555 dimerization interface [polypeptide binding]; other site 446465004556 ligand binding site [chemical binding]; other site 446465004557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 446465004558 CHAD domain; Region: CHAD; cl10506 446465004559 DNA primase; Validated; Region: dnaG; PRK05667 446465004560 CHC2 zinc finger; Region: zf-CHC2; cl02597 446465004561 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 446465004562 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 446465004563 active site 446465004564 metal binding site [ion binding]; metal-binding site 446465004565 interdomain interaction site; other site 446465004566 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 446465004567 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 446465004568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 446465004569 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 446465004570 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 446465004571 FMN binding site [chemical binding]; other site 446465004572 active site 446465004573 catalytic residues [active] 446465004574 substrate binding site [chemical binding]; other site 446465004575 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 446465004576 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465004577 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465004578 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465004579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465004580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465004581 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465004582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004583 dimer interface [polypeptide binding]; other site 446465004584 conserved gate region; other site 446465004585 putative PBP binding loops; other site 446465004586 ABC-ATPase subunit interface; other site 446465004587 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446465004588 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 446465004589 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446465004590 glycyl-tRNA synthetase; Provisional; Region: PRK04173 446465004591 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446465004592 motif 1; other site 446465004593 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 446465004594 motif 1; other site 446465004595 dimer interface [polypeptide binding]; other site 446465004596 active site 446465004597 motif 2; other site 446465004598 motif 3; other site 446465004599 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 446465004600 anticodon binding site; other site 446465004601 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 446465004602 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446465004603 intersubunit interface [polypeptide binding]; other site 446465004604 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 446465004605 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 446465004606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 446465004607 ABC-ATPase subunit interface; other site 446465004608 dimer interface [polypeptide binding]; other site 446465004609 putative PBP binding regions; other site 446465004610 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446465004611 metal binding site 2 [ion binding]; metal-binding site 446465004612 putative DNA binding helix; other site 446465004613 metal binding site 1 [ion binding]; metal-binding site 446465004614 dimer interface [polypeptide binding]; other site 446465004615 structural Zn2+ binding site [ion binding]; other site 446465004616 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446465004617 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 446465004618 catalytic residue [active] 446465004619 putative FPP diphosphate binding site; other site 446465004620 putative FPP binding hydrophobic cleft; other site 446465004621 dimer interface [polypeptide binding]; other site 446465004622 putative IPP diphosphate binding site; other site 446465004623 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 446465004624 Recombination protein O N terminal; Region: RecO_N; pfam11967 446465004625 Recombination protein O C terminal; Region: RecO_C; pfam02565 446465004626 EcsC protein family; Region: EcsC; pfam12787 446465004627 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 446465004628 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 446465004629 trans-aconitate 2-methyltransferase; Provisional; Region: PRK01683 446465004630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465004631 S-adenosylmethionine binding site [chemical binding]; other site 446465004632 M28, and M42; Region: Zinc_peptidase_like; cl14876 446465004633 metal binding site [ion binding]; metal-binding site 446465004634 fatty acyl-CoA reductase 2; Region: PLN02503 446465004635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465004636 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446465004637 putative dimerization interface [polypeptide binding]; other site 446465004638 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446465004639 2-isopropylmalate synthase; Validated; Region: PRK03739 446465004640 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 446465004641 active site 446465004642 catalytic residues [active] 446465004643 metal binding site [ion binding]; metal-binding site 446465004644 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 446465004645 GTPase Era; Reviewed; Region: era; PRK00089 446465004646 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 446465004647 G1 box; other site 446465004648 GTP/Mg2+ binding site [chemical binding]; other site 446465004649 Switch I region; other site 446465004650 G2 box; other site 446465004651 Switch II region; other site 446465004652 G3 box; other site 446465004653 G4 box; other site 446465004654 G5 box; other site 446465004655 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 446465004656 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446465004657 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446465004658 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 446465004659 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 446465004660 PhoH-like protein; Region: PhoH; cl12134 446465004661 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 446465004662 nucleotide binding site/active site [active] 446465004663 HIT family signature motif; other site 446465004664 catalytic residue [active] 446465004665 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 446465004666 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 446465004667 chaperone protein DnaJ; Provisional; Region: PRK14278 446465004668 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 446465004669 HSP70 interaction site [polypeptide binding]; other site 446465004670 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 446465004671 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 446465004672 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 446465004673 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 446465004674 HrcA protein C terminal domain; Region: HrcA; pfam01628 446465004675 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 446465004676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 446465004677 coproporphyrinogen III oxidase; Validated; Region: PRK05628 446465004678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 446465004679 FeS/SAM binding site; other site 446465004680 HemN C-terminal region; Region: HemN_C; pfam06969 446465004681 MOSC domain; Region: MOSC; pfam03473 446465004682 GTP-binding protein LepA; Provisional; Region: PRK05433 446465004683 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 446465004684 G1 box; other site 446465004685 putative GEF interaction site [polypeptide binding]; other site 446465004686 GTP/Mg2+ binding site [chemical binding]; other site 446465004687 Switch I region; other site 446465004688 G2 box; other site 446465004689 G3 box; other site 446465004690 Switch II region; other site 446465004691 G4 box; other site 446465004692 G5 box; other site 446465004693 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 446465004694 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 446465004695 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 446465004696 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 446465004697 Uncharacterized conserved protein [Function unknown]; Region: COG2308 446465004698 Domain of unknown function (DUF404); Region: DUF404; pfam04169 446465004699 Domain of unknown function (DUF407); Region: DUF407; pfam04174 446465004700 PemK-like protein; Region: PemK; cl00995 446465004701 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 446465004702 hypothetical protein; Reviewed; Region: PRK07914 446465004703 Competence protein; Region: Competence; cl00471 446465004704 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465004705 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 446465004706 Vitamin K epoxide reductase family; Region: VKOR; cl01729 446465004707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465004708 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 446465004709 NAD(P) binding site [chemical binding]; other site 446465004710 active site 446465004711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465004712 peptide synthase; Provisional; Region: PRK09274 446465004713 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 446465004714 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 446465004715 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446465004716 active site 446465004717 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 446465004718 AP (apurinic/apyrimidinic) site pocket; other site 446465004719 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465004720 DNA interaction; other site 446465004721 Metal-binding active site; metal-binding site 446465004722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465004723 Thymidine kinase; Region: TK; cl00631 446465004724 Proline dehydrogenase; Region: Pro_dh; cl03282 446465004725 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446465004726 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465004727 NAD(P) binding site [chemical binding]; other site 446465004728 catalytic residues [active] 446465004729 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446465004730 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 446465004731 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 446465004732 active site 446465004733 substrate binding site [chemical binding]; other site 446465004734 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446465004735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465004736 Walker A/P-loop; other site 446465004737 ATP binding site [chemical binding]; other site 446465004738 Q-loop/lid; other site 446465004739 ABC transporter signature motif; other site 446465004740 Walker B; other site 446465004741 D-loop; other site 446465004742 H-loop/switch region; other site 446465004743 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 446465004744 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446465004745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465004746 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 446465004747 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 446465004748 active site 446465004749 HIGH motif; other site 446465004750 KMSKS motif; other site 446465004751 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 446465004752 tRNA binding surface [nucleotide binding]; other site 446465004753 anticodon binding site; other site 446465004754 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 446465004755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465004756 putative substrate translocation pore; other site 446465004757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465004758 transketolase; Reviewed; Region: PRK05899 446465004759 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446465004760 TPP-binding site [chemical binding]; other site 446465004761 dimer interface [polypeptide binding]; other site 446465004762 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446465004763 PYR/PP interface [polypeptide binding]; other site 446465004764 dimer interface [polypeptide binding]; other site 446465004765 TPP binding site [chemical binding]; other site 446465004766 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465004767 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446465004768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465004769 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446465004770 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446465004771 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 446465004772 homodimer interface [polypeptide binding]; other site 446465004773 substrate-cofactor binding pocket; other site 446465004774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465004775 catalytic residue [active] 446465004776 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446465004777 FAD binding pocket [chemical binding]; other site 446465004778 FAD binding motif [chemical binding]; other site 446465004779 phosphate binding motif [ion binding]; other site 446465004780 NAD binding pocket [chemical binding]; other site 446465004781 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 446465004782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465004783 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 446465004784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 446465004785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 446465004786 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 446465004787 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 446465004788 active site 446465004789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465004790 non-specific DNA binding site [nucleotide binding]; other site 446465004791 salt bridge; other site 446465004792 sequence-specific DNA binding site [nucleotide binding]; other site 446465004793 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 446465004794 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 446465004795 hinge; other site 446465004796 active site 446465004797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465004798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465004799 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465004800 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465004801 Walker A/P-loop; other site 446465004802 ATP binding site [chemical binding]; other site 446465004803 Q-loop/lid; other site 446465004804 ABC transporter signature motif; other site 446465004805 Walker B; other site 446465004806 D-loop; other site 446465004807 H-loop/switch region; other site 446465004808 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465004809 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465004810 Walker A/P-loop; other site 446465004811 ATP binding site [chemical binding]; other site 446465004812 Q-loop/lid; other site 446465004813 ABC transporter signature motif; other site 446465004814 Walker B; other site 446465004815 D-loop; other site 446465004816 H-loop/switch region; other site 446465004817 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465004818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004819 dimer interface [polypeptide binding]; other site 446465004820 conserved gate region; other site 446465004821 putative PBP binding loops; other site 446465004822 ABC-ATPase subunit interface; other site 446465004823 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465004824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004825 dimer interface [polypeptide binding]; other site 446465004826 conserved gate region; other site 446465004827 putative PBP binding loops; other site 446465004828 ABC-ATPase subunit interface; other site 446465004829 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446465004830 substrate binding site [chemical binding]; other site 446465004831 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465004832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 446465004833 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446465004834 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 446465004835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465004836 DNA binding site [nucleotide binding] 446465004837 domain linker motif; other site 446465004838 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465004839 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465004840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465004841 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446465004842 conserved cys residue [active] 446465004843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 446465004844 hypothetical protein; Provisional; Region: PRK13663 446465004845 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 446465004846 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 446465004847 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 446465004848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465004849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465004850 DNA binding site [nucleotide binding] 446465004851 domain linker motif; other site 446465004852 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 446465004853 putative dimerization interface [polypeptide binding]; other site 446465004854 putative ligand binding site [chemical binding]; other site 446465004855 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465004856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004857 dimer interface [polypeptide binding]; other site 446465004858 conserved gate region; other site 446465004859 ABC-ATPase subunit interface; other site 446465004860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465004861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004862 dimer interface [polypeptide binding]; other site 446465004863 conserved gate region; other site 446465004864 putative PBP binding loops; other site 446465004865 ABC-ATPase subunit interface; other site 446465004866 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465004867 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 446465004868 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 446465004869 substrate binding [chemical binding]; other site 446465004870 active site 446465004871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465004872 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446465004873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465004874 TM2 domain; Region: TM2; cl00984 446465004875 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465004876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465004877 putative substrate translocation pore; other site 446465004878 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 446465004879 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 446465004880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465004881 ATP binding site [chemical binding]; other site 446465004882 putative Mg++ binding site [ion binding]; other site 446465004883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465004884 nucleotide binding region [chemical binding]; other site 446465004885 ATP-binding site [chemical binding]; other site 446465004886 RQC domain; Region: RQC; pfam09382 446465004887 HRDC domain; Region: HRDC; cl02578 446465004888 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 446465004889 putative active site [active] 446465004890 putative metal binding site [ion binding]; other site 446465004891 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 446465004892 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 446465004893 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465004894 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465004895 Walker A/P-loop; other site 446465004896 ATP binding site [chemical binding]; other site 446465004897 Q-loop/lid; other site 446465004898 ABC transporter signature motif; other site 446465004899 Walker B; other site 446465004900 D-loop; other site 446465004901 H-loop/switch region; other site 446465004902 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465004903 Walker A/P-loop; other site 446465004904 ATP binding site [chemical binding]; other site 446465004905 Q-loop/lid; other site 446465004906 ABC transporter signature motif; other site 446465004907 Walker B; other site 446465004908 D-loop; other site 446465004909 H-loop/switch region; other site 446465004910 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465004911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004912 dimer interface [polypeptide binding]; other site 446465004913 conserved gate region; other site 446465004914 ABC-ATPase subunit interface; other site 446465004915 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465004916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465004917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004918 putative PBP binding loops; other site 446465004919 dimer interface [polypeptide binding]; other site 446465004920 ABC-ATPase subunit interface; other site 446465004921 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446465004922 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465004923 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 446465004924 putative metal binding site [ion binding]; other site 446465004925 LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879 446465004926 Cupin domain; Region: Cupin_2; cl09118 446465004927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446465004928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465004929 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 446465004930 putative dimerization interface [polypeptide binding]; other site 446465004931 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 446465004932 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446465004933 DNA binding residues [nucleotide binding] 446465004934 TOBE domain; Region: TOBE_2; cl01440 446465004935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465004936 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446465004937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465004938 putative PBP binding loops; other site 446465004939 ABC-ATPase subunit interface; other site 446465004940 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 446465004941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465004942 Walker A/P-loop; other site 446465004943 ATP binding site [chemical binding]; other site 446465004944 Q-loop/lid; other site 446465004945 ABC transporter signature motif; other site 446465004946 Walker B; other site 446465004947 D-loop; other site 446465004948 H-loop/switch region; other site 446465004949 Cation efflux family; Region: Cation_efflux; cl00316 446465004950 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446465004951 minor groove reading motif; other site 446465004952 helix-hairpin-helix signature motif; other site 446465004953 active site 446465004954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465004955 catalytic core [active] 446465004956 Domain of unknown function DUF143; Region: DUF143; cl00519 446465004957 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 446465004958 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 446465004959 active site 446465004960 (T/H)XGH motif; other site 446465004961 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 446465004962 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 446465004963 putative catalytic cysteine [active] 446465004964 gamma-glutamyl kinase; Provisional; Region: PRK05429 446465004965 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 446465004966 nucleotide binding site [chemical binding]; other site 446465004967 homotetrameric interface [polypeptide binding]; other site 446465004968 putative phosphate binding site [ion binding]; other site 446465004969 putative allosteric binding site; other site 446465004970 PUA domain; Region: PUA; cl00607 446465004971 GTPase CgtA; Reviewed; Region: obgE; PRK12296 446465004972 GTP1/OBG; Region: GTP1_OBG; pfam01018 446465004973 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 446465004974 G1 box; other site 446465004975 GTP/Mg2+ binding site [chemical binding]; other site 446465004976 Switch I region; other site 446465004977 G2 box; other site 446465004978 G3 box; other site 446465004979 Switch II region; other site 446465004980 G4 box; other site 446465004981 G5 box; other site 446465004982 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 446465004983 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 446465004984 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 446465004985 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 446465004986 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 446465004987 homodimer interface [polypeptide binding]; other site 446465004988 oligonucleotide binding site [chemical binding]; other site 446465004989 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 446465004990 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446465004991 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 446465004992 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465004993 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 446465004994 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 446465004995 Walker A/P-loop; other site 446465004996 ATP binding site [chemical binding]; other site 446465004997 Q-loop/lid; other site 446465004998 ABC transporter signature motif; other site 446465004999 Walker B; other site 446465005000 D-loop; other site 446465005001 H-loop/switch region; other site 446465005002 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 446465005003 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 446465005004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005005 Walker A/P-loop; other site 446465005006 ATP binding site [chemical binding]; other site 446465005007 Q-loop/lid; other site 446465005008 ABC transporter signature motif; other site 446465005009 Walker B; other site 446465005010 D-loop; other site 446465005011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465005012 Histidine kinase; Region: HisKA_3; pfam07730 446465005013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465005014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465005015 active site 446465005016 phosphorylation site [posttranslational modification] 446465005017 intermolecular recognition site; other site 446465005018 dimerization interface [polypeptide binding]; other site 446465005019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 446465005020 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 446465005021 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 446465005022 DNA binding site [nucleotide binding] 446465005023 catalytic residue [active] 446465005024 H2TH interface [polypeptide binding]; other site 446465005025 putative catalytic residues [active] 446465005026 turnover-facilitating residue; other site 446465005027 intercalation triad [nucleotide binding]; other site 446465005028 8OG recognition residue [nucleotide binding]; other site 446465005029 putative reading head residues; other site 446465005030 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446465005031 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446465005032 ribonuclease III; Reviewed; Region: rnc; PRK00102 446465005033 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 446465005034 dimerization interface [polypeptide binding]; other site 446465005035 active site 446465005036 metal binding site [ion binding]; metal-binding site 446465005037 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 446465005038 dsRNA binding site [nucleotide binding]; other site 446465005039 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 446465005040 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 446465005041 active site 446465005042 (T/H)XGH motif; other site 446465005043 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 446465005044 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465005045 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 446465005046 active site 446465005047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465005048 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 446465005049 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 446465005050 ssDNA binding site; other site 446465005051 generic binding surface II; other site 446465005052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005053 ATP binding site [chemical binding]; other site 446465005054 putative Mg++ binding site [ion binding]; other site 446465005055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005056 nucleotide binding region [chemical binding]; other site 446465005057 ATP-binding site [chemical binding]; other site 446465005058 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 446465005059 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 446465005060 active site pocket [active] 446465005061 oxyanion hole [active] 446465005062 catalytic triad [active] 446465005063 active site nucleophile [active] 446465005064 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446465005065 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 446465005066 putative NAD(P) binding site [chemical binding]; other site 446465005067 putative substrate binding site [chemical binding]; other site 446465005068 catalytic Zn binding site [ion binding]; other site 446465005069 structural Zn binding site [ion binding]; other site 446465005070 dimer interface [polypeptide binding]; other site 446465005071 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 446465005072 dimerization interface [polypeptide binding]; other site 446465005073 thiamine monophosphate kinase; Provisional; Region: PRK05731 446465005074 ATP binding site [chemical binding]; other site 446465005075 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 446465005076 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 446465005077 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446465005078 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465005079 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446465005080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005081 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446465005082 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446465005083 putative acyl-acceptor binding pocket; other site 446465005084 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 446465005085 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 446465005086 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 446465005087 hinge; other site 446465005088 active site 446465005089 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 446465005090 substrate binding site [chemical binding]; other site 446465005091 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 446465005092 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 446465005093 substrate binding site [chemical binding]; other site 446465005094 ligand binding site [chemical binding]; other site 446465005095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465005096 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465005097 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465005098 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 446465005099 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446465005100 HIGH motif; other site 446465005101 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446465005102 active site 446465005103 KMSKS motif; other site 446465005104 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 446465005105 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 446465005106 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 446465005107 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 446465005108 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465005109 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005110 ATP binding site [chemical binding]; other site 446465005111 putative Mg++ binding site [ion binding]; other site 446465005112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005113 nucleotide binding region [chemical binding]; other site 446465005114 ATP-binding site [chemical binding]; other site 446465005115 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 446465005116 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 446465005117 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 446465005118 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 446465005119 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 446465005120 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 446465005121 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 446465005122 [4Fe-4S] binding site [ion binding]; other site 446465005123 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 446465005124 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 446465005125 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 446465005126 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 446465005127 molybdopterin cofactor binding site; other site 446465005128 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 446465005129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465005130 putative substrate translocation pore; other site 446465005131 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 446465005132 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446465005133 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 446465005134 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 446465005135 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 446465005136 active site 446465005137 catalytic residues [active] 446465005138 metal binding site [ion binding]; metal-binding site 446465005139 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 446465005140 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 446465005141 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 446465005142 homodimer interface [polypeptide binding]; other site 446465005143 substrate-cofactor binding pocket; other site 446465005144 catalytic residue [active] 446465005145 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 446465005146 isocitrate dehydrogenase; Validated; Region: PRK06451 446465005147 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 446465005148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005149 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 446465005150 putative L-serine binding site [chemical binding]; other site 446465005151 ketol-acid reductoisomerase; Provisional; Region: PRK05479 446465005152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005153 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 446465005154 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 446465005155 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 446465005156 putative valine binding site [chemical binding]; other site 446465005157 dimer interface [polypeptide binding]; other site 446465005158 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 446465005159 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 446465005160 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446465005161 PYR/PP interface [polypeptide binding]; other site 446465005162 dimer interface [polypeptide binding]; other site 446465005163 TPP binding site [chemical binding]; other site 446465005164 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446465005165 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 446465005166 TPP-binding site [chemical binding]; other site 446465005167 dimer interface [polypeptide binding]; other site 446465005168 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446465005169 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465005170 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 446465005171 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446465005172 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 446465005173 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 446465005174 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 446465005175 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and...; Region: Chelatase_Class_II; cl02784 446465005176 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and...; Region: Chelatase_Class_II; cl02784 446465005177 active site 446465005178 Dehydratase family; Region: ILVD_EDD; cl00340 446465005179 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 446465005180 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446465005181 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 446465005182 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 446465005183 GatB domain; Region: GatB_Yqey; cl11497 446465005184 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446465005185 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 446465005186 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 446465005187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465005188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005189 ATP binding site [chemical binding]; other site 446465005190 putative Mg++ binding site [ion binding]; other site 446465005191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005192 nucleotide binding region [chemical binding]; other site 446465005193 ATP-binding site [chemical binding]; other site 446465005194 Ligase N family; Region: LIGANc; smart00532 446465005195 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 446465005196 nucleotide binding pocket [chemical binding]; other site 446465005197 K-X-D-G motif; other site 446465005198 catalytic site [active] 446465005199 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 446465005200 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 446465005201 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 446465005202 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 446465005203 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 446465005204 Dimer interface [polypeptide binding]; other site 446465005205 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 446465005206 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 446465005207 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446465005208 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465005209 catalytic residue [active] 446465005210 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446465005211 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446465005212 metal ion-dependent adhesion site (MIDAS); other site 446465005213 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446465005214 metal ion-dependent adhesion site (MIDAS); other site 446465005215 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 446465005216 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465005217 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465005218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005221 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 446465005222 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446465005223 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465005224 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 446465005225 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465005226 glycogen branching enzyme; Provisional; Region: PRK05402 446465005227 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 446465005228 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465005229 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 446465005230 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 446465005231 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465005232 Protein of unknown function DUF91; Region: DUF91; cl00709 446465005233 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465005234 active site 446465005235 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 446465005236 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 446465005237 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 446465005238 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446465005239 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 446465005240 alpha subunit interaction interface [polypeptide binding]; other site 446465005241 Walker A motif; other site 446465005242 ATP binding site [chemical binding]; other site 446465005243 Walker B motif; other site 446465005244 inhibitor binding site; inhibition site 446465005245 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446465005246 ATP synthase; Region: ATP-synt; cl00365 446465005247 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 446465005248 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446465005249 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 446465005250 beta subunit interaction interface [polypeptide binding]; other site 446465005251 Walker A motif; other site 446465005252 ATP binding site [chemical binding]; other site 446465005253 Walker B motif; other site 446465005254 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446465005255 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 446465005256 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 446465005257 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 446465005258 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 446465005259 ATP synthase subunit C; Region: ATP-synt_C; cl00466 446465005260 ATP synthase A chain; Region: ATP-synt_A; cl00413 446465005261 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 446465005262 Mg++ binding site [ion binding]; other site 446465005263 putative catalytic motif [active] 446465005264 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 446465005265 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446465005266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465005267 S-adenosylmethionine binding site [chemical binding]; other site 446465005268 RF-1 domain; Region: RF-1; cl02875 446465005269 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 446465005270 RF-1 domain; Region: RF-1; cl02875 446465005271 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 446465005272 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465005273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465005274 DNA binding site [nucleotide binding] 446465005275 domain linker motif; other site 446465005276 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465005277 dimerization interface [polypeptide binding]; other site 446465005278 ligand binding site [chemical binding]; other site 446465005279 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465005280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005281 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446465005282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465005283 active site 446465005284 catalytic tetrad [active] 446465005285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465005286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465005287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465005288 dimer interface [polypeptide binding]; other site 446465005289 conserved gate region; other site 446465005290 putative PBP binding loops; other site 446465005291 ABC-ATPase subunit interface; other site 446465005292 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465005293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465005294 dimer interface [polypeptide binding]; other site 446465005295 conserved gate region; other site 446465005296 putative PBP binding loops; other site 446465005297 ABC-ATPase subunit interface; other site 446465005298 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 446465005299 transcription termination factor Rho; Provisional; Region: PRK12608 446465005300 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 446465005301 RNA binding site [nucleotide binding]; other site 446465005302 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 446465005303 multimer interface [polypeptide binding]; other site 446465005304 Walker A motif; other site 446465005305 ATP binding site [chemical binding]; other site 446465005306 Walker B motif; other site 446465005307 homoserine kinase; Provisional; Region: PRK01212 446465005308 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 446465005309 threonine synthase; Reviewed; Region: PRK06721 446465005310 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 446465005311 homodimer interface [polypeptide binding]; other site 446465005312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465005313 catalytic residue [active] 446465005314 homoserine dehydrogenase; Provisional; Region: PRK06349 446465005315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005316 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 446465005317 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 446465005318 diaminopimelate decarboxylase; Region: lysA; TIGR01048 446465005319 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 446465005320 active site 446465005321 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465005322 substrate binding site [chemical binding]; other site 446465005323 catalytic residues [active] 446465005324 dimer interface [polypeptide binding]; other site 446465005325 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 446465005326 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 446465005327 active site 446465005328 homotetramer interface [polypeptide binding]; other site 446465005329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465005330 UGMP family protein; Validated; Region: PRK09604 446465005331 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 446465005332 Peptidase family M23; Region: Peptidase_M23; pfam01551 446465005333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465005334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465005335 active site 446465005336 phosphorylation site [posttranslational modification] 446465005337 intermolecular recognition site; other site 446465005338 dimerization interface [polypeptide binding]; other site 446465005339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 446465005340 DNA binding site [nucleotide binding] 446465005341 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 446465005342 dimerization interface [polypeptide binding]; other site 446465005343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 446465005344 dimer interface [polypeptide binding]; other site 446465005345 phosphorylation site [posttranslational modification] 446465005346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465005347 ATP binding site [chemical binding]; other site 446465005348 Mg2+ binding site [ion binding]; other site 446465005349 G-X-G motif; other site 446465005350 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446465005351 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446465005352 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446465005353 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 446465005354 TPP-binding site [chemical binding]; other site 446465005355 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 446465005356 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446465005357 active site 446465005358 catalytic triad [active] 446465005359 oxyanion hole [active] 446465005360 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 446465005361 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 446465005362 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446465005363 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 446465005364 DNA binding residues [nucleotide binding] 446465005365 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 446465005366 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 446465005367 hinge; other site 446465005368 active site 446465005369 Predicted GTPases [General function prediction only]; Region: COG1162 446465005370 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 446465005371 GTPase/OB domain interface [polypeptide binding]; other site 446465005372 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446465005373 GTP/Mg2+ binding site [chemical binding]; other site 446465005374 G4 box; other site 446465005375 G5 box; other site 446465005376 G1 box; other site 446465005377 Switch I region; other site 446465005378 G2 box; other site 446465005379 G3 box; other site 446465005380 Switch II region; other site 446465005381 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 446465005382 active site 446465005383 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 446465005384 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 446465005385 active site 446465005386 ADP/pyrophosphate binding site [chemical binding]; other site 446465005387 allosteric effector site; other site 446465005388 fructose-1,6-bisphosphate binding site; other site 446465005389 IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 446465005390 catalytic site [active] 446465005391 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 446465005392 active site 446465005393 catalytic triad [active] 446465005394 oxyanion hole [active] 446465005395 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 446465005396 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 446465005397 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446465005398 dimer interface [polypeptide binding]; other site 446465005399 ssDNA binding site [nucleotide binding]; other site 446465005400 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446465005401 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446465005402 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446465005403 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446465005404 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005405 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 446465005406 ATP binding site [chemical binding]; other site 446465005407 putative Mg++ binding site [ion binding]; other site 446465005408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005409 nucleotide binding region [chemical binding]; other site 446465005410 ATP-binding site [chemical binding]; other site 446465005411 DEAD/H associated; Region: DEAD_assoc; pfam08494 446465005412 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446465005413 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 446465005414 putative DNA binding site [nucleotide binding]; other site 446465005415 catalytic residue [active] 446465005416 putative H2TH interface [polypeptide binding]; other site 446465005417 putative catalytic residues [active] 446465005418 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446465005419 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 446465005420 putative active site [active] 446465005421 putative substrate binding site [chemical binding]; other site 446465005422 catalytic site [active] 446465005423 dimer interface [polypeptide binding]; other site 446465005424 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 446465005425 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 446465005426 dimerization interface [polypeptide binding]; other site 446465005427 putative active cleft [active] 446465005428 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446465005429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005430 Walker A/P-loop; other site 446465005431 ATP binding site [chemical binding]; other site 446465005432 Q-loop/lid; other site 446465005433 ABC transporter signature motif; other site 446465005434 Walker B; other site 446465005435 D-loop; other site 446465005436 H-loop/switch region; other site 446465005437 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465005438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465005439 DNA-binding site [nucleotide binding]; DNA binding site 446465005440 FCD domain; Region: FCD; cl11656 446465005441 Domain of unknown function DUF77; Region: DUF77; cl00307 446465005442 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 446465005443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005444 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446465005445 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 446465005446 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 446465005447 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 446465005448 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446465005449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465005450 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465005451 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465005452 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 446465005453 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446465005454 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cl00246 446465005455 FAD binding site [chemical binding]; other site 446465005456 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446465005457 synthetase active site [active] 446465005458 NTP binding site [chemical binding]; other site 446465005459 metal binding site [ion binding]; metal-binding site 446465005460 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446465005461 extended (e) SDRs; Region: SDR_e; cd08946 446465005462 NAD(P) binding site [chemical binding]; other site 446465005463 active site 446465005464 substrate binding site [chemical binding]; other site 446465005465 Cytochrome P450; Region: p450; cl12078 446465005466 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446465005467 DinB superfamily; Region: DinB_2; cl00986 446465005468 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 446465005469 copper exporting ATPase; Provisional; Region: copA; PRK10671 446465005470 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446465005471 metal-binding site [ion binding] 446465005472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446465005473 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446465005474 putative homotetramer interface [polypeptide binding]; other site 446465005475 putative homodimer interface [polypeptide binding]; other site 446465005476 putative allosteric switch controlling residues; other site 446465005477 putative metal binding site [ion binding]; other site 446465005478 putative homodimer-homodimer interface [polypeptide binding]; other site 446465005479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465005480 Isochorismatase family; Region: Isochorismatase; pfam00857 446465005481 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446465005482 catalytic triad [active] 446465005483 conserved cis-peptide bond; other site 446465005484 oxidoreductase; Provisional; Region: PRK06128 446465005485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005486 NAD(P) binding site [chemical binding]; other site 446465005487 active site 446465005488 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 446465005489 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465005490 NAD binding site [chemical binding]; other site 446465005491 catalytic Zn binding site [ion binding]; other site 446465005492 structural Zn binding site [ion binding]; other site 446465005493 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446465005494 Cation efflux family; Region: Cation_efflux; cl00316 446465005495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 446465005496 substrate binding pocket [chemical binding]; other site 446465005497 ANTAR domain; Region: ANTAR; pfam03861 446465005498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465005499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465005500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005501 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465005502 Walker A/P-loop; other site 446465005503 ATP binding site [chemical binding]; other site 446465005504 Q-loop/lid; other site 446465005505 ABC transporter signature motif; other site 446465005506 Walker B; other site 446465005507 D-loop; other site 446465005508 H-loop/switch region; other site 446465005509 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446465005510 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 446465005511 metal binding site [ion binding]; metal-binding site 446465005512 dimer interface [polypeptide binding]; other site 446465005513 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446465005514 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465005515 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446465005516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005517 NAD(P) binding site [chemical binding]; other site 446465005518 active site 446465005519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465005520 SEC-C motif; Region: SEC-C; cl12132 446465005521 hypothetical protein; Provisional; Region: PRK04233 446465005522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005523 NAD(P) binding site [chemical binding]; other site 446465005524 active site 446465005525 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465005526 catalytic core [active] 446465005527 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465005528 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 446465005529 active site 446465005530 dimerization interface [polypeptide binding]; other site 446465005531 ribonuclease PH; Reviewed; Region: rph; PRK00173 446465005532 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 446465005533 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 446465005534 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465005535 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446465005536 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 446465005537 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 446465005538 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 446465005539 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 446465005540 active site 446465005541 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446465005542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005543 ATP binding site [chemical binding]; other site 446465005544 putative Mg++ binding site [ion binding]; other site 446465005545 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 446465005546 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446465005547 Beta-lactamase; Region: Beta-lactamase; cl01009 446465005548 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465005549 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465005550 Walker A/P-loop; other site 446465005551 ATP binding site [chemical binding]; other site 446465005552 Q-loop/lid; other site 446465005553 ABC transporter signature motif; other site 446465005554 Walker B; other site 446465005555 D-loop; other site 446465005556 H-loop/switch region; other site 446465005557 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465005558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465005559 dimer interface [polypeptide binding]; other site 446465005560 conserved gate region; other site 446465005561 ABC-ATPase subunit interface; other site 446465005562 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465005563 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465005564 Walker A/P-loop; other site 446465005565 ATP binding site [chemical binding]; other site 446465005566 Q-loop/lid; other site 446465005567 ABC transporter signature motif; other site 446465005568 Walker B; other site 446465005569 D-loop; other site 446465005570 H-loop/switch region; other site 446465005571 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465005572 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465005573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465005574 dimer interface [polypeptide binding]; other site 446465005575 conserved gate region; other site 446465005576 putative PBP binding loops; other site 446465005577 ABC-ATPase subunit interface; other site 446465005578 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446465005579 substrate binding site [chemical binding]; other site 446465005580 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465005581 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446465005582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465005583 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 446465005584 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446465005585 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446465005586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005587 NAD(P) binding pocket [chemical binding]; other site 446465005588 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 446465005589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005590 ATP binding site [chemical binding]; other site 446465005591 putative Mg++ binding site [ion binding]; other site 446465005592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005593 nucleotide binding region [chemical binding]; other site 446465005594 ATP-binding site [chemical binding]; other site 446465005595 Helicase associated domain (HA2); Region: HA2; cl04503 446465005596 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 446465005597 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446465005598 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465005599 Phosphotransferase enzyme family; Region: APH; pfam01636 446465005600 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446465005601 active site 446465005602 ATP binding site [chemical binding]; other site 446465005603 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465005604 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465005605 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 446465005606 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 446465005607 SmpB-tmRNA interface; other site 446465005608 Peptidase family M23; Region: Peptidase_M23; pfam01551 446465005609 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 446465005610 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 446465005611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005612 Walker A/P-loop; other site 446465005613 ATP binding site [chemical binding]; other site 446465005614 Q-loop/lid; other site 446465005615 ABC transporter signature motif; other site 446465005616 Walker B; other site 446465005617 D-loop; other site 446465005618 H-loop/switch region; other site 446465005619 peptide chain release factor 2; Validated; Region: prfB; PRK00578 446465005620 RF-1 domain; Region: RF-1; cl02875 446465005621 RF-1 domain; Region: RF-1; cl02875 446465005622 Glycerate kinase family; Region: Gly_kinase; cl00841 446465005623 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 446465005624 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 446465005625 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446465005626 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 446465005627 ATP binding site [chemical binding]; other site 446465005628 Walker A motif; other site 446465005629 hexamer interface [polypeptide binding]; other site 446465005630 Walker B motif; other site 446465005631 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 446465005632 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 446465005633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465005634 Histidine kinase; Region: HisKA_3; pfam07730 446465005635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465005636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465005637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465005638 active site 446465005639 phosphorylation site [posttranslational modification] 446465005640 intermolecular recognition site; other site 446465005641 dimerization interface [polypeptide binding]; other site 446465005642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 446465005643 DNA binding residues [nucleotide binding] 446465005644 dimerization interface [polypeptide binding]; other site 446465005645 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446465005646 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446465005647 Walker A/P-loop; other site 446465005648 ATP binding site [chemical binding]; other site 446465005649 Q-loop/lid; other site 446465005650 ABC transporter signature motif; other site 446465005651 Walker B; other site 446465005652 D-loop; other site 446465005653 H-loop/switch region; other site 446465005654 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 446465005655 FtsX-like permease family; Region: FtsX; pfam02687 446465005656 Transcription factor WhiB; Region: Whib; pfam02467 446465005657 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 446465005658 sensory histidine kinase AtoS; Provisional; Region: PRK11360 446465005659 Histidine kinase; Region: HisKA_2; cl06527 446465005660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465005661 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 446465005662 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 446465005663 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 446465005664 SAF domain; Region: SAF; cl00555 446465005665 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446465005666 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 446465005667 putative peptidoglycan binding site; other site 446465005668 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 446465005669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 446465005670 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 446465005671 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 446465005672 30S subunit binding site; other site 446465005673 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 446465005674 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465005675 lipoprotein LpqB; Provisional; Region: PRK13614 446465005676 Sporulation and spore germination; Region: Germane; pfam10646 446465005677 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 446465005678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 446465005679 dimer interface [polypeptide binding]; other site 446465005680 phosphorylation site [posttranslational modification] 446465005681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465005682 ATP binding site [chemical binding]; other site 446465005683 Mg2+ binding site [ion binding]; other site 446465005684 G-X-G motif; other site 446465005685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465005686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465005687 active site 446465005688 phosphorylation site [posttranslational modification] 446465005689 intermolecular recognition site; other site 446465005690 dimerization interface [polypeptide binding]; other site 446465005691 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 446465005692 DNA binding site [nucleotide binding] 446465005693 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 446465005694 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465005695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465005696 Walker A motif; other site 446465005697 ATP binding site [chemical binding]; other site 446465005698 Walker B motif; other site 446465005699 arginine finger; other site 446465005700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005701 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446465005702 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465005703 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446465005704 active site 446465005705 ATP binding site [chemical binding]; other site 446465005706 substrate binding site [chemical binding]; other site 446465005707 Integral membrane protein DUF95; Region: DUF95; cl00572 446465005708 RDD family; Region: RDD; cl00746 446465005709 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 446465005710 active site 446465005711 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 446465005712 substrate binding site [chemical binding]; other site 446465005713 metal binding site [ion binding]; metal-binding site 446465005714 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 446465005715 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 446465005716 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465005717 Transcription factor WhiB; Region: Whib; pfam02467 446465005718 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 446465005719 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 446465005720 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 446465005721 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446465005722 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 446465005723 Walker A/P-loop; other site 446465005724 ATP binding site [chemical binding]; other site 446465005725 Q-loop/lid; other site 446465005726 ABC transporter signature motif; other site 446465005727 Walker B; other site 446465005728 D-loop; other site 446465005729 H-loop/switch region; other site 446465005730 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446465005731 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446465005732 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465005733 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 446465005734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465005735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465005736 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465005737 active site 446465005738 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465005739 active site 446465005740 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446465005741 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446465005742 Ligand binding site [chemical binding]; other site 446465005743 Putative Catalytic site [active] 446465005744 DXD motif; other site 446465005745 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 446465005746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005747 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446465005748 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446465005749 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 446465005750 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446465005751 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 446465005752 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446465005753 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 446465005754 active site 446465005755 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 446465005756 homodimer interface [polypeptide binding]; other site 446465005757 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465005758 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465005759 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465005760 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 446465005761 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 446465005762 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 446465005763 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465005764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005765 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465005766 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 446465005767 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446465005768 inhibitor-cofactor binding pocket; inhibition site 446465005769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465005770 catalytic residue [active] 446465005771 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 446465005772 putative trimer interface [polypeptide binding]; other site 446465005773 putative active site [active] 446465005774 putative substrate binding site [chemical binding]; other site 446465005775 putative CoA binding site [chemical binding]; other site 446465005776 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 446465005777 AIR carboxylase; Region: AIRC; cl00310 446465005778 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 446465005779 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465005780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446465005781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 446465005782 dimer interface [polypeptide binding]; other site 446465005783 phosphorylation site [posttranslational modification] 446465005784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465005785 ATP binding site [chemical binding]; other site 446465005786 Mg2+ binding site [ion binding]; other site 446465005787 G-X-G motif; other site 446465005788 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465005789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465005790 active site 446465005791 phosphorylation site [posttranslational modification] 446465005792 intermolecular recognition site; other site 446465005793 dimerization interface [polypeptide binding]; other site 446465005794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 446465005795 DNA binding site [nucleotide binding] 446465005796 cyclase homology domain; Region: CHD; cd07302 446465005797 nucleotidyl binding site; other site 446465005798 metal binding site [ion binding]; metal-binding site 446465005799 dimer interface [polypeptide binding]; other site 446465005800 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 446465005801 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446465005802 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 446465005803 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 446465005804 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 446465005805 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 446465005806 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446465005807 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 446465005808 putative active site [active] 446465005809 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446465005810 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446465005811 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465005812 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 446465005813 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 446465005814 carboxyltransferase (CT) interaction site; other site 446465005815 biotinylation site [posttranslational modification]; other site 446465005816 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 446465005817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465005818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465005819 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446465005820 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 446465005821 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 446465005822 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 446465005823 active site 446465005824 substrate binding site [chemical binding]; other site 446465005825 metal binding site [ion binding]; metal-binding site 446465005826 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 446465005827 intersubunit interface [polypeptide binding]; other site 446465005828 active site 446465005829 catalytic residue [active] 446465005830 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 446465005831 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 446465005832 putative NAD(P) binding site [chemical binding]; other site 446465005833 catalytic Zn binding site [ion binding]; other site 446465005834 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005835 Active site [active] 446465005836 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 446465005837 nudix motif; other site 446465005838 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 446465005839 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446465005840 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446465005841 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 446465005842 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 446465005843 active site 446465005844 catalytic motif [active] 446465005845 Zn binding site [ion binding]; other site 446465005846 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446465005847 TM-ABC transporter signature motif; other site 446465005848 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446465005849 TM-ABC transporter signature motif; other site 446465005850 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 446465005851 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 446465005852 Walker A/P-loop; other site 446465005853 ATP binding site [chemical binding]; other site 446465005854 Q-loop/lid; other site 446465005855 ABC transporter signature motif; other site 446465005856 Walker B; other site 446465005857 D-loop; other site 446465005858 H-loop/switch region; other site 446465005859 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 446465005860 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 446465005861 ligand binding site [chemical binding]; other site 446465005862 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 446465005863 amidohydrolase; Region: amidohydrolases; TIGR01891 446465005864 metal binding site [ion binding]; metal-binding site 446465005865 putative dimer interface [polypeptide binding]; other site 446465005866 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 446465005867 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 446465005868 Substrate binding site [chemical binding]; other site 446465005869 Cupin domain; Region: Cupin_2; cl09118 446465005870 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 446465005871 putative Iron-sulfur protein interface [polypeptide binding]; other site 446465005872 putative proximal heme binding site [chemical binding]; other site 446465005873 putative SdhD-like interface [polypeptide binding]; other site 446465005874 putative distal heme binding site [chemical binding]; other site 446465005875 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 446465005876 putative Iron-sulfur protein interface [polypeptide binding]; other site 446465005877 putative proximal heme binding site [chemical binding]; other site 446465005878 putative SdhC-like subunit interface [polypeptide binding]; other site 446465005879 putative distal heme binding site [chemical binding]; other site 446465005880 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 446465005881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465005882 domain; Region: Succ_DH_flav_C; pfam02910 446465005883 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 446465005884 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 446465005885 putative active site [active] 446465005886 putative DNA binding site [nucleotide binding]; other site 446465005887 putative phosphate binding site [ion binding]; other site 446465005888 putative catalytic site [active] 446465005889 metal binding site A [ion binding]; metal-binding site 446465005890 putative AP binding site [nucleotide binding]; other site 446465005891 putative metal binding site B [ion binding]; other site 446465005892 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 446465005893 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 446465005894 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 446465005895 homodimer interface [polypeptide binding]; other site 446465005896 NADP binding site [chemical binding]; other site 446465005897 substrate binding site [chemical binding]; other site 446465005898 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 446465005899 dimer interface [polypeptide binding]; other site 446465005900 glycine-pyridoxal phosphate binding site [chemical binding]; other site 446465005901 active site 446465005902 folate binding site [chemical binding]; other site 446465005903 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 446465005904 FAD binding domain; Region: FAD_binding_4; pfam01565 446465005905 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 446465005906 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446465005907 active site 2 [active] 446465005908 active site 1 [active] 446465005909 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 446465005910 active site 446465005911 catalytic site [active] 446465005912 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 446465005913 Protein of unknown function (DUF520); Region: DUF520; cl00723 446465005914 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446465005915 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465005916 phosphopeptide binding site; other site 446465005917 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 446465005918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005919 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005920 Protein kinase domain; Region: Pkinase; pfam00069 446465005921 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465005922 active site 446465005923 ATP binding site [chemical binding]; other site 446465005924 substrate binding site [chemical binding]; other site 446465005925 activation loop (A-loop); other site 446465005926 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 446465005927 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446465005928 Protein phosphatase 2C; Region: PP2C; pfam00481 446465005929 Active site [active] 446465005930 RDD family; Region: RDD; cl00746 446465005931 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 446465005932 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 446465005933 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446465005934 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465005935 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465005936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465005937 Walker A motif; other site 446465005938 ATP binding site [chemical binding]; other site 446465005939 Walker B motif; other site 446465005940 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465005941 arginine finger; other site 446465005942 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446465005943 Interdomain contacts; other site 446465005944 Cytokine receptor motif; other site 446465005945 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446465005946 Interdomain contacts; other site 446465005947 Cytokine receptor motif; other site 446465005948 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 446465005949 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446465005950 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446465005951 substrate binding pocket [chemical binding]; other site 446465005952 chain length determination region; other site 446465005953 substrate-Mg2+ binding site; other site 446465005954 catalytic residues [active] 446465005955 aspartate-rich region 1; other site 446465005956 active site lid residues [active] 446465005957 aspartate-rich region 2; other site 446465005958 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446465005959 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 446465005960 active site 446465005961 HIGH motif; other site 446465005962 dimer interface [polypeptide binding]; other site 446465005963 KMSKS motif; other site 446465005964 argininosuccinate lyase; Provisional; Region: PRK00855 446465005965 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 446465005966 active sites [active] 446465005967 tetramer interface [polypeptide binding]; other site 446465005968 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 446465005969 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 446465005970 ANP binding site [chemical binding]; other site 446465005971 Substrate Binding Site II [chemical binding]; other site 446465005972 Substrate Binding Site I [chemical binding]; other site 446465005973 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 446465005974 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 446465005975 ornithine carbamoyltransferase; Provisional; Region: PRK00779 446465005976 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446465005977 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446465005978 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 446465005979 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 446465005980 inhibitor-cofactor binding pocket; inhibition site 446465005981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465005982 catalytic residue [active] 446465005983 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 446465005984 feedback inhibition sensing region; other site 446465005985 homohexameric interface [polypeptide binding]; other site 446465005986 nucleotide binding site [chemical binding]; other site 446465005987 N-acetyl-L-glutamate binding site [chemical binding]; other site 446465005988 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 446465005989 heterotetramer interface [polypeptide binding]; other site 446465005990 active site pocket [active] 446465005991 cleavage site 446465005992 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 446465005993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005994 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 446465005995 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465005996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465005997 dimer interface [polypeptide binding]; other site 446465005998 conserved gate region; other site 446465005999 putative PBP binding loops; other site 446465006000 ABC-ATPase subunit interface; other site 446465006001 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465006002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006003 dimer interface [polypeptide binding]; other site 446465006004 conserved gate region; other site 446465006005 putative PBP binding loops; other site 446465006006 ABC-ATPase subunit interface; other site 446465006007 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446465006008 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465006009 Walker A/P-loop; other site 446465006010 ATP binding site [chemical binding]; other site 446465006011 Q-loop/lid; other site 446465006012 ABC transporter signature motif; other site 446465006013 Walker B; other site 446465006014 D-loop; other site 446465006015 H-loop/switch region; other site 446465006016 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465006017 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446465006018 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465006019 Walker A/P-loop; other site 446465006020 ATP binding site [chemical binding]; other site 446465006021 Q-loop/lid; other site 446465006022 ABC transporter signature motif; other site 446465006023 Walker B; other site 446465006024 D-loop; other site 446465006025 H-loop/switch region; other site 446465006026 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465006027 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446465006028 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465006029 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 446465006030 active site 446465006031 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 446465006032 active site 446465006033 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948 446465006034 active site 446465006035 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 446465006036 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 446465006037 putative tRNA-binding site [nucleotide binding]; other site 446465006038 B3/4 domain; Region: B3_4; cl11458 446465006039 tRNA synthetase B5 domain; Region: B5; cl08394 446465006040 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 446465006041 dimer interface [polypeptide binding]; other site 446465006042 motif 1; other site 446465006043 motif 3; other site 446465006044 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 446465006045 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 446465006046 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 446465006047 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 446465006048 dimer interface [polypeptide binding]; other site 446465006049 motif 1; other site 446465006050 active site 446465006051 motif 2; other site 446465006052 motif 3; other site 446465006053 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 446465006054 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 446465006055 NAD binding site [chemical binding]; other site 446465006056 catalytic Zn binding site [ion binding]; other site 446465006057 substrate binding site [chemical binding]; other site 446465006058 structural Zn binding site [ion binding]; other site 446465006059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465006060 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 446465006061 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446465006062 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 446465006063 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446465006064 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 446465006065 23S rRNA binding site [nucleotide binding]; other site 446465006066 L21 binding site [polypeptide binding]; other site 446465006067 L13 binding site [polypeptide binding]; other site 446465006068 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 446465006069 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 446465006070 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 446465006071 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 446465006072 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 446465006073 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 446465006074 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 446465006075 catalytic residues [active] 446465006076 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 446465006077 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 446465006078 putative active site [active] 446465006079 oxyanion strand; other site 446465006080 catalytic triad [active] 446465006081 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 446465006082 4-fold oligomerization interface [polypeptide binding]; other site 446465006083 putative active site pocket [active] 446465006084 metal binding residues [ion binding]; metal-binding site 446465006085 3-fold/trimer interface [polypeptide binding]; other site 446465006086 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 446465006087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465006088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465006089 homodimer interface [polypeptide binding]; other site 446465006090 catalytic residue [active] 446465006091 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 446465006092 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 446465006093 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 446465006094 NAD binding site [chemical binding]; other site 446465006095 dimerization interface [polypeptide binding]; other site 446465006096 product binding site; other site 446465006097 substrate binding site [chemical binding]; other site 446465006098 zinc binding site [ion binding]; other site 446465006099 catalytic residues [active] 446465006100 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 446465006101 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 446465006102 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 446465006103 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465006104 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446465006105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465006106 active site 446465006107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465006108 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465006109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465006110 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465006111 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 446465006112 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 446465006113 heme-binding site [chemical binding]; other site 446465006114 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 446465006115 FAD binding pocket [chemical binding]; other site 446465006116 FAD binding motif [chemical binding]; other site 446465006117 phosphate binding motif [ion binding]; other site 446465006118 beta-alpha-beta structure motif; other site 446465006119 NAD binding pocket [chemical binding]; other site 446465006120 Heme binding pocket [chemical binding]; other site 446465006121 Protein of unknown function, DUF488; Region: DUF488; cl01246 446465006122 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 446465006123 dimer interface [polypeptide binding]; other site 446465006124 catalytic triad [active] 446465006125 peroxidatic and resolving cysteines [active] 446465006126 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 446465006127 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446465006128 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 446465006129 active site 446465006130 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446465006131 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446465006132 putative phosphoketolase; Provisional; Region: PRK05261 446465006133 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 446465006134 TPP-binding site; other site 446465006135 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 446465006136 XFP C-terminal domain; Region: XFP_C; pfam09363 446465006137 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 446465006138 Acylphosphatase; Region: Acylphosphatase; cl00551 446465006139 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446465006140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465006141 putative substrate translocation pore; other site 446465006142 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 446465006143 NAD(P) binding site [chemical binding]; other site 446465006144 putative active site [active] 446465006145 Protein of unknown function (DUF808); Region: DUF808; cl01002 446465006146 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465006147 BCCT family transporter; Region: BCCT; cl00569 446465006148 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446465006149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465006150 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 446465006151 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 446465006152 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 446465006153 putative substrate binding site [chemical binding]; other site 446465006154 putative ATP binding site [chemical binding]; other site 446465006155 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446465006156 active site 446465006157 phosphorylation site [posttranslational modification] 446465006158 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 446465006159 P-loop; other site 446465006160 active site 446465006161 phosphorylation site [posttranslational modification] 446465006162 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 446465006163 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 446465006164 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 446465006165 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446465006166 Thymidine kinase; Region: TK; cl00631 446465006167 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 446465006168 Integral membrane protein TerC family; Region: TerC; cl10468 446465006169 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446465006170 dimer interface [polypeptide binding]; other site 446465006171 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 446465006172 Phosphotransferase enzyme family; Region: APH; pfam01636 446465006173 putative active site [active] 446465006174 putative substrate binding site [chemical binding]; other site 446465006175 ATP binding site [chemical binding]; other site 446465006176 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446465006177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465006178 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465006179 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465006180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006181 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465006182 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465006183 SurA N-terminal domain; Region: SurA_N; pfam09312 446465006184 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 446465006185 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465006186 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 446465006187 gating phenylalanine in ion channel; other site 446465006188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465006189 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465006190 putative substrate translocation pore; other site 446465006191 choline transport protein BetT; Provisional; Region: PRK09928 446465006192 BCCT family transporter; Region: BCCT; cl00569 446465006193 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 446465006194 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465006195 tetramerization interface [polypeptide binding]; other site 446465006196 NAD(P) binding site [chemical binding]; other site 446465006197 catalytic residues [active] 446465006198 choline dehydrogenase; Validated; Region: PRK02106 446465006199 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446465006200 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446465006201 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446465006202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446465006203 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465006204 Sulfatase; Region: Sulfatase; cl10460 446465006205 choline-sulfatase; Region: chol_sulfatase; TIGR03417 446465006206 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 446465006207 BCCT family transporter; Region: BCCT; cl00569 446465006208 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 446465006209 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 446465006210 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 446465006211 aromatic arch; other site 446465006212 DCoH dimer interaction site [polypeptide binding]; other site 446465006213 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 446465006214 DCoH tetramer interaction site [polypeptide binding]; other site 446465006215 substrate binding site [chemical binding]; other site 446465006216 RF-1 domain; Region: RF-1; cl02875 446465006217 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 446465006218 putative acyl-acceptor binding pocket; other site 446465006219 Protein of unknown function (DUF429); Region: DUF429; cl12046 446465006220 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 446465006221 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 446465006222 active site 446465006223 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446465006224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006225 dimer interface [polypeptide binding]; other site 446465006226 conserved gate region; other site 446465006227 putative PBP binding loops; other site 446465006228 ABC-ATPase subunit interface; other site 446465006229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006230 dimer interface [polypeptide binding]; other site 446465006231 conserved gate region; other site 446465006232 putative PBP binding loops; other site 446465006233 ABC-ATPase subunit interface; other site 446465006234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 446465006235 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446465006236 substrate binding pocket [chemical binding]; other site 446465006237 membrane-bound complex binding site; other site 446465006238 hinge residues; other site 446465006239 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465006240 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 446465006241 Walker A/P-loop; other site 446465006242 ATP binding site [chemical binding]; other site 446465006243 Q-loop/lid; other site 446465006244 ABC transporter signature motif; other site 446465006245 Walker B; other site 446465006246 D-loop; other site 446465006247 H-loop/switch region; other site 446465006248 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446465006249 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 446465006250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006251 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446465006252 glycosyltransferase, MGT family; Region: MGT; TIGR01426 446465006253 active site 446465006254 TDP-binding site; other site 446465006255 acceptor substrate-binding pocket; other site 446465006256 homodimer interface [polypeptide binding]; other site 446465006257 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 446465006258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 446465006259 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 446465006260 active site 446465006261 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446465006262 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 446465006263 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 446465006264 PhnA protein; Region: PhnA; pfam03831 446465006265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465006266 dimerization interface [polypeptide binding]; other site 446465006267 putative DNA binding site [nucleotide binding]; other site 446465006268 putative Zn2+ binding site [ion binding]; other site 446465006269 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446465006270 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446465006271 active site 446465006272 FMN binding site [chemical binding]; other site 446465006273 substrate binding site [chemical binding]; other site 446465006274 homotetramer interface [polypeptide binding]; other site 446465006275 catalytic residue [active] 446465006276 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 446465006277 NAD(P) binding site [chemical binding]; other site 446465006278 putative active site [active] 446465006279 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 446465006280 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446465006281 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446465006282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465006283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465006284 dimerization interface [polypeptide binding]; other site 446465006285 putative DNA binding site [nucleotide binding]; other site 446465006286 putative Zn2+ binding site [ion binding]; other site 446465006287 GTP-binding protein YchF; Reviewed; Region: PRK09601 446465006288 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 446465006289 G1 box; other site 446465006290 GTP/Mg2+ binding site [chemical binding]; other site 446465006291 Switch I region; other site 446465006292 G2 box; other site 446465006293 Switch II region; other site 446465006294 G3 box; other site 446465006295 G4 box; other site 446465006296 G5 box; other site 446465006297 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 446465006298 RmuC family; Region: RmuC; pfam02646 446465006299 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 446465006300 LytB protein; Region: LYTB; cl00507 446465006301 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 446465006302 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 446465006303 generic binding surface II; other site 446465006304 generic binding surface I; other site 446465006305 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 446465006306 cell division protein ZipA; Provisional; Region: PRK03427 446465006307 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 446465006308 fumarate hydratase; Reviewed; Region: fumC; PRK00485 446465006309 Class II fumarases; Region: Fumarase_classII; cd01362 446465006310 active site 446465006311 tetramer interface [polypeptide binding]; other site 446465006312 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 446465006313 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 446465006314 putative active site [active] 446465006315 PhoH-like protein; Region: PhoH; cl12134 446465006316 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 446465006317 catalytic residue [active] 446465006318 putative FPP diphosphate binding site; other site 446465006319 putative FPP binding hydrophobic cleft; other site 446465006320 dimer interface [polypeptide binding]; other site 446465006321 putative IPP diphosphate binding site; other site 446465006322 Haemolysin-III related; Region: HlyIII; cl03831 446465006323 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446465006324 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 446465006325 domain; Region: GreA_GreB_N; pfam03449 446465006326 C-term; Region: GreA_GreB; pfam01272 446465006327 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446465006328 Domain of unknown function DUF20; Region: UPF0118; cl00465 446465006329 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446465006330 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446465006331 Walker A/P-loop; other site 446465006332 ATP binding site [chemical binding]; other site 446465006333 Q-loop/lid; other site 446465006334 ABC transporter signature motif; other site 446465006335 Walker B; other site 446465006336 D-loop; other site 446465006337 H-loop/switch region; other site 446465006338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465006339 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 446465006340 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 446465006341 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 446465006342 alanine racemase; Reviewed; Region: alr; PRK00053 446465006343 active site 446465006344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465006345 dimer interface [polypeptide binding]; other site 446465006346 substrate binding site [chemical binding]; other site 446465006347 catalytic residues [active] 446465006348 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 446465006349 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 446465006350 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 446465006351 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 446465006352 glutaminase active site [active] 446465006353 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446465006354 dimer interface [polypeptide binding]; other site 446465006355 active site 446465006356 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446465006357 dimer interface [polypeptide binding]; other site 446465006358 active site 446465006359 pantothenate kinase; Provisional; Region: PRK05439 446465006360 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 446465006361 ATP-binding site [chemical binding]; other site 446465006362 CoA-binding site [chemical binding]; other site 446465006363 Mg2+-binding site [ion binding]; other site 446465006364 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 446465006365 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 446465006366 active site 446465006367 substrate binding site [chemical binding]; other site 446465006368 metal binding site [ion binding]; metal-binding site 446465006369 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446465006370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465006371 ATP binding site [chemical binding]; other site 446465006372 putative Mg++ binding site [ion binding]; other site 446465006373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465006374 nucleotide binding region [chemical binding]; other site 446465006375 ATP-binding site [chemical binding]; other site 446465006376 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 446465006377 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 446465006378 23S rRNA interface [nucleotide binding]; other site 446465006379 L3 interface [polypeptide binding]; other site 446465006380 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 446465006381 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 446465006382 dimerization interface 3.5A [polypeptide binding]; other site 446465006383 active site 446465006384 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 446465006385 Predicted transcriptional regulator [Transcription]; Region: COG2345 446465006386 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cl00436 446465006387 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 446465006388 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 446465006389 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446465006390 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 446465006391 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 446465006392 ATP binding site [chemical binding]; other site 446465006393 active site 446465006394 substrate binding site [chemical binding]; other site 446465006395 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465006396 Walker A/P-loop; other site 446465006397 ATP binding site [chemical binding]; other site 446465006398 Q-loop/lid; other site 446465006399 ABC transporter signature motif; other site 446465006400 Walker B; other site 446465006401 D-loop; other site 446465006402 H-loop/switch region; other site 446465006403 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 446465006404 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 446465006405 Walker A/P-loop; other site 446465006406 ATP binding site [chemical binding]; other site 446465006407 Q-loop/lid; other site 446465006408 ABC transporter signature motif; other site 446465006409 Walker B; other site 446465006410 D-loop; other site 446465006411 H-loop/switch region; other site 446465006412 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 446465006413 YKOF-related Family; Region: Ykof; pfam07615 446465006414 YKOF-related Family; Region: Ykof; pfam07615 446465006415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465006416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465006417 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 446465006418 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 446465006419 putative active site [active] 446465006420 catalytic triad [active] 446465006421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465006422 S-adenosylmethionine binding site [chemical binding]; other site 446465006423 Pirin-related protein [General function prediction only]; Region: COG1741 446465006424 Cupin domain; Region: Cupin_2; cl09118 446465006425 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 446465006426 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 446465006427 DNA binding residues [nucleotide binding] 446465006428 dimer interface [polypeptide binding]; other site 446465006429 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446465006430 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_3; cd02653 446465006431 active site 446465006432 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 446465006433 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446465006434 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 446465006435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006436 NAD(P) binding site [chemical binding]; other site 446465006437 active site 446465006438 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 446465006439 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446465006440 dimer interface [polypeptide binding]; other site 446465006441 active site 446465006442 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446465006443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465006444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465006445 active site 446465006446 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 446465006447 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 446465006448 dimerization interface [polypeptide binding]; other site 446465006449 ATP binding site [chemical binding]; other site 446465006450 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 446465006451 dimerization interface [polypeptide binding]; other site 446465006452 ATP binding site [chemical binding]; other site 446465006453 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 446465006454 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 446465006455 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 446465006456 alphaNTD homodimer interface [polypeptide binding]; other site 446465006457 alphaNTD - beta interaction site [polypeptide binding]; other site 446465006458 alphaNTD - beta' interaction site [polypeptide binding]; other site 446465006459 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 446465006460 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 446465006461 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 446465006462 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 446465006463 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 446465006464 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 446465006465 rRNA binding site [nucleotide binding]; other site 446465006466 predicted 30S ribosome binding site; other site 446465006467 methionine aminopeptidase; Reviewed; Region: PRK07281 446465006468 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446465006469 active site 446465006470 adenylate kinase; Reviewed; Region: adk; PRK00279 446465006471 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 446465006472 AMP-binding site [chemical binding]; other site 446465006473 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 446465006474 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 446465006475 SecY translocase; Region: SecY; pfam00344 446465006476 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 446465006477 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 446465006478 23S rRNA binding site [nucleotide binding]; other site 446465006479 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 446465006480 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 446465006481 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 446465006482 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 446465006483 5S rRNA interface [nucleotide binding]; other site 446465006484 23S rRNA interface [nucleotide binding]; other site 446465006485 L5 interface [polypeptide binding]; other site 446465006486 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 446465006487 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446465006488 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446465006489 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 446465006490 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 446465006491 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 446465006492 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 446465006493 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 446465006494 KOW motif; Region: KOW; cl00354 446465006495 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 446465006496 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 446465006497 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 446465006498 L23 interface [polypeptide binding]; other site 446465006499 signal recognition particle (SRP54) interaction site; other site 446465006500 trigger factor interaction site; other site 446465006501 23S rRNA interface [nucleotide binding]; other site 446465006502 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 446465006503 23S rRNA interface [nucleotide binding]; other site 446465006504 5S rRNA interface [nucleotide binding]; other site 446465006505 putative antibiotic binding site [chemical binding]; other site 446465006506 L25 interface [polypeptide binding]; other site 446465006507 L27 interface [polypeptide binding]; other site 446465006508 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 446465006509 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 446465006510 G-X-X-G motif; other site 446465006511 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 446465006512 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 446465006513 putative translocon binding site; other site 446465006514 protein-rRNA interface [nucleotide binding]; other site 446465006515 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 446465006516 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 446465006517 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 446465006518 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 446465006519 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 446465006520 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 446465006521 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 446465006522 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 446465006523 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465006524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006525 dimer interface [polypeptide binding]; other site 446465006526 conserved gate region; other site 446465006527 putative PBP binding loops; other site 446465006528 ABC-ATPase subunit interface; other site 446465006529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465006530 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446465006531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465006532 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465006533 elongation factor Tu; Reviewed; Region: PRK00049 446465006534 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 446465006535 G1 box; other site 446465006536 GEF interaction site [polypeptide binding]; other site 446465006537 GTP/Mg2+ binding site [chemical binding]; other site 446465006538 Switch I region; other site 446465006539 G2 box; other site 446465006540 G3 box; other site 446465006541 Switch II region; other site 446465006542 G4 box; other site 446465006543 G5 box; other site 446465006544 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 446465006545 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 446465006546 Antibiotic Binding Site [chemical binding]; other site 446465006547 elongation factor G; Reviewed; Region: PRK00007 446465006548 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 446465006549 G1 box; other site 446465006550 putative GEF interaction site [polypeptide binding]; other site 446465006551 GTP/Mg2+ binding site [chemical binding]; other site 446465006552 Switch I region; other site 446465006553 G2 box; other site 446465006554 G3 box; other site 446465006555 Switch II region; other site 446465006556 G4 box; other site 446465006557 G5 box; other site 446465006558 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 446465006559 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 446465006560 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 446465006561 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 446465006562 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 446465006563 S17 interaction site [polypeptide binding]; other site 446465006564 S8 interaction site; other site 446465006565 16S rRNA interaction site [nucleotide binding]; other site 446465006566 streptomycin interaction site [chemical binding]; other site 446465006567 23S rRNA interaction site [nucleotide binding]; other site 446465006568 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 446465006569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 446465006570 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446465006571 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446465006572 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446465006573 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 446465006574 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 446465006575 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 446465006576 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 446465006577 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 446465006578 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 446465006579 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 446465006580 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 446465006581 DNA binding site [nucleotide binding] 446465006582 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 446465006583 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 446465006584 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446465006585 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446465006586 RPB10 interaction site [polypeptide binding]; other site 446465006587 RPB1 interaction site [polypeptide binding]; other site 446465006588 RPB11 interaction site [polypeptide binding]; other site 446465006589 RPB3 interaction site [polypeptide binding]; other site 446465006590 RPB12 interaction site [polypeptide binding]; other site 446465006591 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 446465006592 putative active site [active] 446465006593 catalytic triad [active] 446465006594 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 446465006595 PA/protease or protease-like domain interface [polypeptide binding]; other site 446465006596 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 446465006597 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 446465006598 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 446465006599 L11 interface [polypeptide binding]; other site 446465006600 putative EF-Tu interaction site [polypeptide binding]; other site 446465006601 putative EF-G interaction site [polypeptide binding]; other site 446465006602 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 446465006603 23S rRNA interface [nucleotide binding]; other site 446465006604 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 446465006605 mRNA/rRNA interface [nucleotide binding]; other site 446465006606 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 446465006607 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 446465006608 23S rRNA interface [nucleotide binding]; other site 446465006609 L7/L12 interface [polypeptide binding]; other site 446465006610 putative thiostrepton binding site; other site 446465006611 L25 interface [polypeptide binding]; other site 446465006612 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 446465006613 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 446465006614 putative homodimer interface [polypeptide binding]; other site 446465006615 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 446465006616 aspartate aminotransferase; Provisional; Region: PRK08361 446465006617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465006618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465006619 homodimer interface [polypeptide binding]; other site 446465006620 catalytic residue [active] 446465006621 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465006622 active site 446465006623 galactokinase; Provisional; Region: PRK05101 446465006624 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446465006625 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 446465006626 Uncharacterized conserved protein [Function unknown]; Region: COG2966 446465006627 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 446465006628 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 446465006629 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 446465006630 Aspartase; Region: Aspartase; cd01357 446465006631 active sites [active] 446465006632 tetramer interface [polypeptide binding]; other site 446465006633 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 446465006634 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 446465006635 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 446465006636 purine monophosphate binding site [chemical binding]; other site 446465006637 dimer interface [polypeptide binding]; other site 446465006638 putative catalytic residues [active] 446465006639 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 446465006640 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 446465006641 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 446465006642 active site 446465006643 substrate binding site [chemical binding]; other site 446465006644 cosubstrate binding site; other site 446465006645 catalytic site [active] 446465006646 Protein of unknown function (DUF3431); Region: DUF3431; pfam11913 446465006647 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446465006648 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 446465006649 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446465006650 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 446465006651 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 446465006652 protein binding site [polypeptide binding]; other site 446465006653 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 446465006654 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 446465006655 dimer interface [polypeptide binding]; other site 446465006656 tetramer interface [polypeptide binding]; other site 446465006657 PYR/PP interface [polypeptide binding]; other site 446465006658 TPP binding site [chemical binding]; other site 446465006659 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 446465006660 O-succinylbenzoate synthase; Provisional; Region: PRK02901 446465006661 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 446465006662 active site 446465006663 naphthoate synthase; Validated; Region: PRK08321 446465006664 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 446465006665 substrate binding site [chemical binding]; other site 446465006666 oxyanion hole (OAH) forming residues; other site 446465006667 trimer interface [polypeptide binding]; other site 446465006668 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 446465006669 UbiA prenyltransferase family; Region: UbiA; cl00337 446465006670 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 446465006671 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 446465006672 ResB-like family; Region: ResB; pfam05140 446465006673 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 446465006674 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 446465006675 catalytic residues [active] 446465006676 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465006677 catalytic core [active] 446465006678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465006679 YceI-like domain; Region: YceI; cl01001 446465006680 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465006681 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 446465006682 G1 box; other site 446465006683 GTP/Mg2+ binding site [chemical binding]; other site 446465006684 Switch I region; other site 446465006685 G2 box; other site 446465006686 Switch II region; other site 446465006687 G3 box; other site 446465006688 G4 box; other site 446465006689 G5 box; other site 446465006690 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 446465006691 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 446465006692 G1 box; other site 446465006693 GTP/Mg2+ binding site [chemical binding]; other site 446465006694 Switch I region; other site 446465006695 G2 box; other site 446465006696 Switch II region; other site 446465006697 G3 box; other site 446465006698 G4 box; other site 446465006699 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 446465006700 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 446465006701 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 446465006702 Cation transport protein; Region: TrkH; cl10514 446465006703 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446465006704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006705 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 446465006706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006707 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 446465006708 Domain of unknown function (DUF368); Region: DUF368; cl00893 446465006709 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446465006710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465006711 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 446465006712 Copper resistance protein CopC; Region: CopC; cl01012 446465006713 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 446465006714 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 446465006715 GTP binding site [chemical binding]; other site 446465006716 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446465006717 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446465006718 active site 446465006719 catalytic triad [active] 446465006720 dimer interface [polypeptide binding]; other site 446465006721 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446465006722 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446465006723 ligand binding site [chemical binding]; other site 446465006724 flexible hinge region; other site 446465006725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465006726 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446465006727 metal-binding site [ion binding] 446465006728 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446465006729 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446465006730 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446465006731 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446465006732 putative NAD(P) binding site [chemical binding]; other site 446465006733 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446465006734 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465006735 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446465006736 Sulfate transporter family; Region: Sulfate_transp; cl00967 446465006737 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446465006738 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 446465006739 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 446465006740 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465006741 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 446465006742 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 446465006743 Walker A/P-loop; other site 446465006744 ATP binding site [chemical binding]; other site 446465006745 Q-loop/lid; other site 446465006746 ABC transporter signature motif; other site 446465006747 Walker B; other site 446465006748 D-loop; other site 446465006749 H-loop/switch region; other site 446465006750 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 446465006751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006752 dimer interface [polypeptide binding]; other site 446465006753 conserved gate region; other site 446465006754 putative PBP binding loops; other site 446465006755 ABC-ATPase subunit interface; other site 446465006756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465006757 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446465006758 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465006759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006760 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465006761 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465006762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465006763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465006764 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446465006765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465006766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006767 dimer interface [polypeptide binding]; other site 446465006768 conserved gate region; other site 446465006769 putative PBP binding loops; other site 446465006770 ABC-ATPase subunit interface; other site 446465006771 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446465006772 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465006773 Cupin domain; Region: Cupin_2; cl09118 446465006774 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465006775 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 446465006776 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446465006777 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465006778 active site 446465006779 catalytic tetrad [active] 446465006780 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446465006781 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446465006782 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446465006783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465006784 Coenzyme A binding pocket [chemical binding]; other site 446465006785 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 446465006786 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 446465006787 inhibitor-cofactor binding pocket; inhibition site 446465006788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465006789 catalytic residue [active] 446465006790 Cupin domain; Region: Cupin_2; cl09118 446465006791 Uncharacterized conserved protein [Function unknown]; Region: COG1739 446465006792 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 446465006793 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 446465006794 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446465006795 dimer interface [polypeptide binding]; other site 446465006796 putative radical transfer pathway; other site 446465006797 diiron center [ion binding]; other site 446465006798 tyrosyl radical; other site 446465006799 Predicted membrane protein [Function unknown]; Region: COG2311 446465006800 Protein of unknown function (DUF418); Region: DUF418; cl12135 446465006801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465006802 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 446465006803 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 446465006804 Class I ribonucleotide reductase; Region: RNR_I; cd01679 446465006805 active site 446465006806 dimer interface [polypeptide binding]; other site 446465006807 catalytic residues [active] 446465006808 effector binding site; other site 446465006809 R2 peptide binding site; other site 446465006810 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 446465006811 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 446465006812 catalytic residues [active] 446465006813 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465006814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006815 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446465006816 putative acyl-acceptor binding pocket; other site 446465006817 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446465006818 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 446465006819 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 446465006820 tetramer interface [polypeptide binding]; other site 446465006821 heme binding pocket [chemical binding]; other site 446465006822 NADPH binding site [chemical binding]; other site 446465006823 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446465006824 metal binding site 2 [ion binding]; metal-binding site 446465006825 putative DNA binding helix; other site 446465006826 metal binding site 1 [ion binding]; metal-binding site 446465006827 dimer interface [polypeptide binding]; other site 446465006828 structural Zn2+ binding site [ion binding]; other site 446465006829 short chain dehydrogenase; Provisional; Region: PRK07677 446465006830 classical (c) SDRs; Region: SDR_c; cd05233 446465006831 NAD(P) binding site [chemical binding]; other site 446465006832 active site 446465006833 classical (c) SDRs; Region: SDR_c; cd05233 446465006834 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446465006835 NAD(P) binding site [chemical binding]; other site 446465006836 active site 446465006837 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465006838 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446465006839 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 446465006840 Walker A/P-loop; other site 446465006841 ATP binding site [chemical binding]; other site 446465006842 Q-loop/lid; other site 446465006843 ABC transporter signature motif; other site 446465006844 Walker B; other site 446465006845 D-loop; other site 446465006846 H-loop/switch region; other site 446465006847 Histidine kinase; Region: HisKA_3; pfam07730 446465006848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446465006849 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465006850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465006851 active site 446465006852 phosphorylation site [posttranslational modification] 446465006853 intermolecular recognition site; other site 446465006854 dimerization interface [polypeptide binding]; other site 446465006855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 446465006856 DNA binding residues [nucleotide binding] 446465006857 dimerization interface [polypeptide binding]; other site 446465006858 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 446465006859 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 446465006860 Prostaglandin dehydrogenases; Region: PGDH; cd05288 446465006861 NAD(P) binding site [chemical binding]; other site 446465006862 substrate binding site [chemical binding]; other site 446465006863 dimer interface [polypeptide binding]; other site 446465006864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465006865 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 446465006866 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 446465006867 Potassium binding sites [ion binding]; other site 446465006868 Cesium cation binding sites [ion binding]; other site 446465006869 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 446465006870 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 446465006871 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 446465006872 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 446465006873 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 446465006874 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 446465006875 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 446465006876 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 446465006877 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 446465006878 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 446465006879 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 446465006880 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446465006881 trimer interface [polypeptide binding]; other site 446465006882 active site 446465006883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465006884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465006885 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465006886 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 446465006887 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 446465006888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465006889 motif II; other site 446465006890 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 446465006891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465006892 active site 446465006893 motif I; other site 446465006894 motif II; other site 446465006895 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 446465006896 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446465006897 homodimer interface [polypeptide binding]; other site 446465006898 substrate-cofactor binding pocket; other site 446465006899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465006900 catalytic residue [active] 446465006901 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446465006902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465006903 Walker A/P-loop; other site 446465006904 ATP binding site [chemical binding]; other site 446465006905 Q-loop/lid; other site 446465006906 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 446465006907 ABC transporter signature motif; other site 446465006908 ABC transporter signature motif; other site 446465006909 Walker B; other site 446465006910 Walker B; other site 446465006911 D-loop; other site 446465006912 D-loop; other site 446465006913 H-loop/switch region; other site 446465006914 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 446465006915 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 446465006916 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 446465006917 putative active site [active] 446465006918 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 446465006919 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465006920 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446465006921 CrcB-like protein; Region: CRCB; cl09114 446465006922 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446465006923 E3 interaction surface; other site 446465006924 lipoyl attachment site [posttranslational modification]; other site 446465006925 e3 binding domain; Region: E3_binding; pfam02817 446465006926 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446465006927 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446465006928 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446465006929 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446465006930 alpha subunit interface [polypeptide binding]; other site 446465006931 TPP binding site [chemical binding]; other site 446465006932 heterodimer interface [polypeptide binding]; other site 446465006933 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465006934 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 446465006935 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446465006936 TPP-binding site [chemical binding]; other site 446465006937 heterodimer interface [polypeptide binding]; other site 446465006938 tetramer interface [polypeptide binding]; other site 446465006939 phosphorylation loop region [posttranslational modification] 446465006940 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 446465006941 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465006942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465006943 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465006944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006945 dimer interface [polypeptide binding]; other site 446465006946 conserved gate region; other site 446465006947 putative PBP binding loops; other site 446465006948 ABC-ATPase subunit interface; other site 446465006949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465006950 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465006951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465006953 putative substrate translocation pore; other site 446465006954 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 446465006955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465006956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465006957 homodimer interface [polypeptide binding]; other site 446465006958 catalytic residue [active] 446465006959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465006960 Membrane protein of unknown function; Region: DUF360; cl00850 446465006961 trehalose synthase; Region: treS_nterm; TIGR02456 446465006962 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446465006963 adenylosuccinate lyase; Provisional; Region: PRK09285 446465006964 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446465006965 tetramer interface [polypeptide binding]; other site 446465006966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006967 short chain dehydrogenase; Provisional; Region: PRK12828 446465006968 NAD(P) binding site [chemical binding]; other site 446465006969 active site 446465006970 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 446465006971 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446465006972 active site residue [active] 446465006973 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446465006974 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446465006975 Walker A/P-loop; other site 446465006976 ATP binding site [chemical binding]; other site 446465006977 Q-loop/lid; other site 446465006978 ABC transporter signature motif; other site 446465006979 Walker B; other site 446465006980 D-loop; other site 446465006981 H-loop/switch region; other site 446465006982 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 446465006983 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 446465006984 Walker A/P-loop; other site 446465006985 ATP binding site [chemical binding]; other site 446465006986 Q-loop/lid; other site 446465006987 ABC transporter signature motif; other site 446465006988 Walker B; other site 446465006989 D-loop; other site 446465006990 H-loop/switch region; other site 446465006991 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 446465006992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006993 dimer interface [polypeptide binding]; other site 446465006994 conserved gate region; other site 446465006995 putative PBP binding loops; other site 446465006996 ABC-ATPase subunit interface; other site 446465006997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465006998 dimer interface [polypeptide binding]; other site 446465006999 conserved gate region; other site 446465007000 putative PBP binding loops; other site 446465007001 ABC-ATPase subunit interface; other site 446465007002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465007003 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446465007004 active site 446465007005 Ap6A binding site [chemical binding]; other site 446465007006 nudix motif; other site 446465007007 metal binding site [ion binding]; metal-binding site 446465007008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465007009 catalytic core [active] 446465007010 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446465007011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465007012 Coenzyme A binding pocket [chemical binding]; other site 446465007013 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 446465007014 heme-binding site [chemical binding]; other site 446465007015 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 446465007016 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 446465007017 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446465007018 Predicted membrane protein [Function unknown]; Region: COG4129 446465007019 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 446465007020 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446465007021 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 446465007022 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446465007023 active site 446465007024 intersubunit interface [polypeptide binding]; other site 446465007025 zinc binding site [ion binding]; other site 446465007026 Na+ binding site [ion binding]; other site 446465007027 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446465007028 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446465007029 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 446465007030 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446465007031 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 446465007032 classical (c) SDRs; Region: SDR_c; cd05233 446465007033 NAD(P) binding site [chemical binding]; other site 446465007034 active site 446465007035 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 446465007036 putative phosphate binding site [ion binding]; other site 446465007037 putative catalytic site [active] 446465007038 active site 446465007039 metal binding site A [ion binding]; metal-binding site 446465007040 DNA binding site [nucleotide binding] 446465007041 putative AP binding site [nucleotide binding]; other site 446465007042 putative metal binding site B [ion binding]; other site 446465007043 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 446465007044 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 446465007045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007046 Walker A motif; other site 446465007047 ATP binding site [chemical binding]; other site 446465007048 Walker B motif; other site 446465007049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 446465007050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 446465007051 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 446465007052 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 446465007053 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 446465007054 catalytic residues [active] 446465007055 catalytic nucleophile [active] 446465007056 Presynaptic Site I dimer interface [polypeptide binding]; other site 446465007057 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 446465007058 Synaptic Flat tetramer interface [polypeptide binding]; other site 446465007059 Synaptic Site I dimer interface [polypeptide binding]; other site 446465007060 DNA binding site [nucleotide binding] 446465007061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465007062 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465007063 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 446465007064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465007065 cofactor binding site; other site 446465007066 DNA binding site [nucleotide binding] 446465007067 substrate interaction site [chemical binding]; other site 446465007068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465007069 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 446465007070 catalytic residues [active] 446465007071 catalytic nucleophile [active] 446465007072 Recombinase; Region: Recombinase; pfam07508 446465007073 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 446465007074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465007075 ATP binding site [chemical binding]; other site 446465007076 putative Mg++ binding site [ion binding]; other site 446465007077 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 446465007078 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446465007079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465007080 S-adenosylmethionine binding site [chemical binding]; other site 446465007081 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 446465007082 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 446465007083 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 446465007084 active site 446465007085 interdomain interaction site; other site 446465007086 putative metal-binding site [ion binding]; other site 446465007087 nucleotide binding site [chemical binding]; other site 446465007088 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 446465007089 domain I; other site 446465007090 phosphate binding site [ion binding]; other site 446465007091 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 446465007092 domain II; other site 446465007093 domain III; other site 446465007094 nucleotide binding site [chemical binding]; other site 446465007095 DNA binding groove [nucleotide binding] 446465007096 catalytic site [active] 446465007097 domain IV; other site 446465007098 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465007099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465007100 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 446465007101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007102 dimer interface [polypeptide binding]; other site 446465007103 conserved gate region; other site 446465007104 putative PBP binding loops; other site 446465007105 ABC-ATPase subunit interface; other site 446465007106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007108 dimer interface [polypeptide binding]; other site 446465007109 conserved gate region; other site 446465007110 putative PBP binding loops; other site 446465007111 ABC-ATPase subunit interface; other site 446465007112 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465007113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007114 thymidylate kinase; Validated; Region: tmk; PRK00698 446465007115 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 446465007116 TMP-binding site; other site 446465007117 ATP-binding site [chemical binding]; other site 446465007118 DNA polymerase III subunit delta'; Validated; Region: PRK07940 446465007119 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007120 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 446465007121 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 446465007122 DNA-binding site [nucleotide binding]; DNA binding site 446465007123 RNA-binding motif; other site 446465007124 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 446465007125 putative active site [active] 446465007126 putative CoA binding site [chemical binding]; other site 446465007127 nudix motif; other site 446465007128 metal binding site [ion binding]; metal-binding site 446465007129 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 446465007130 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446465007131 minor groove reading motif; other site 446465007132 helix-hairpin-helix signature motif; other site 446465007133 active site 446465007134 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 446465007135 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446465007136 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446465007137 ligand binding site [chemical binding]; other site 446465007138 flexible hinge region; other site 446465007139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465007140 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465007141 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446465007142 homotrimer interaction site [polypeptide binding]; other site 446465007143 putative active site [active] 446465007144 Transcription factor WhiB; Region: Whib; pfam02467 446465007145 Transglycosylase; Region: Transgly; cl07896 446465007146 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446465007147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 446465007148 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 446465007149 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465007150 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465007151 active site 446465007152 metal binding site [ion binding]; metal-binding site 446465007153 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446465007154 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446465007155 NlpC/P60 family; Region: NLPC_P60; cl11438 446465007156 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i); Region: GH20_chitobiase-like; cd06563 446465007157 active site 446465007158 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 446465007159 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 446465007160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 446465007161 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446465007162 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465007163 active site 446465007164 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446465007165 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446465007166 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 446465007167 substrate binding site [chemical binding]; other site 446465007168 dimer interface [polypeptide binding]; other site 446465007169 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 446465007170 classical (c) SDRs; Region: SDR_c; cd05233 446465007171 NAD(P) binding site [chemical binding]; other site 446465007172 active site 446465007173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465007174 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465007175 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 446465007176 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465007177 Walker A/P-loop; other site 446465007178 ATP binding site [chemical binding]; other site 446465007179 Q-loop/lid; other site 446465007180 ABC transporter signature motif; other site 446465007181 Walker B; other site 446465007182 D-loop; other site 446465007183 H-loop/switch region; other site 446465007184 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446465007185 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465007186 active site 446465007187 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446465007188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465007189 active site 446465007190 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446465007191 YhhN-like protein; Region: YhhN; cl01505 446465007192 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446465007193 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446465007194 Walker A/P-loop; other site 446465007195 ATP binding site [chemical binding]; other site 446465007196 Q-loop/lid; other site 446465007197 ABC transporter signature motif; other site 446465007198 Walker B; other site 446465007199 D-loop; other site 446465007200 H-loop/switch region; other site 446465007201 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446465007202 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446465007203 FAD binding pocket [chemical binding]; other site 446465007204 FAD binding motif [chemical binding]; other site 446465007205 phosphate binding motif [ion binding]; other site 446465007206 NAD binding pocket [chemical binding]; other site 446465007207 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 446465007208 ABC-ATPase subunit interface; other site 446465007209 dimer interface [polypeptide binding]; other site 446465007210 putative PBP binding regions; other site 446465007211 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 446465007212 ABC-ATPase subunit interface; other site 446465007213 dimer interface [polypeptide binding]; other site 446465007214 putative PBP binding regions; other site 446465007215 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 446465007216 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446465007217 intersubunit interface [polypeptide binding]; other site 446465007218 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446465007219 active site 446465007220 DNA binding site [nucleotide binding] 446465007221 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 446465007222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465007223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007224 dimer interface [polypeptide binding]; other site 446465007225 conserved gate region; other site 446465007226 putative PBP binding loops; other site 446465007227 ABC-ATPase subunit interface; other site 446465007228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007229 dimer interface [polypeptide binding]; other site 446465007230 conserved gate region; other site 446465007231 putative PBP binding loops; other site 446465007232 ABC-ATPase subunit interface; other site 446465007233 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 446465007234 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446465007235 domain; Region: Glyco_hydro_2; pfam00703 446465007236 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 446465007237 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 446465007238 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 446465007239 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446465007240 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 446465007241 active site 446465007242 metal binding site [ion binding]; metal-binding site 446465007243 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446465007244 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 446465007245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007246 NAD(P) binding pocket [chemical binding]; other site 446465007247 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 446465007248 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 446465007249 substrate binding site [chemical binding]; other site 446465007250 active site 446465007251 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 446465007252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465007253 Chlorite dismutase; Region: Chlor_dismutase; cl01280 446465007254 ferrochelatase; Reviewed; Region: hemH; PRK00035 446465007255 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 446465007256 C-terminal domain interface [polypeptide binding]; other site 446465007257 active site 446465007258 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 446465007259 active site 446465007260 N-terminal domain interface [polypeptide binding]; other site 446465007261 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 446465007262 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 446465007263 domain interfaces; other site 446465007264 active site 446465007265 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 446465007266 active site 446465007267 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 446465007268 dimer interface [polypeptide binding]; other site 446465007269 active site 446465007270 Schiff base residues; other site 446465007271 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 446465007272 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 446465007273 inhibitor-cofactor binding pocket; inhibition site 446465007274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465007275 catalytic residue [active] 446465007276 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 446465007277 gluconate transporter; Region: gntP; TIGR00791 446465007278 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 446465007279 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465007280 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 446465007281 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 446465007282 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446465007283 NAD binding site [chemical binding]; other site 446465007284 substrate binding site [chemical binding]; other site 446465007285 active site 446465007286 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 446465007287 dihydropteroate synthase; Region: DHPS; TIGR01496 446465007288 substrate binding pocket [chemical binding]; other site 446465007289 dimer interface [polypeptide binding]; other site 446465007290 inhibitor binding site; inhibition site 446465007291 Beta-lactamase; Region: Beta-lactamase; cl01009 446465007292 Beta-lactamase; Region: Beta-lactamase; cl01009 446465007293 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446465007294 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446465007295 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 446465007296 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465007297 phosphopeptide binding site; other site 446465007298 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465007299 phosphopeptide binding site; other site 446465007300 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446465007301 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 446465007302 Active site [active] 446465007303 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 446465007304 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 446465007305 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465007306 active site 446465007307 ATP binding site [chemical binding]; other site 446465007308 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465007309 substrate binding site [chemical binding]; other site 446465007310 activation loop (A-loop); other site 446465007311 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465007312 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465007313 active site 446465007314 ATP binding site [chemical binding]; other site 446465007315 substrate binding site [chemical binding]; other site 446465007316 activation loop (A-loop); other site 446465007317 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 446465007318 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 446465007319 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 446465007320 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 446465007321 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446465007322 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446465007323 glutamine binding [chemical binding]; other site 446465007324 catalytic triad [active] 446465007325 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 446465007326 active site 446465007327 catalytic site [active] 446465007328 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446465007329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007330 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465007331 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446465007332 conserved cys residue [active] 446465007333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465007334 catalytic core [active] 446465007335 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446465007336 FAD binding domain; Region: FAD_binding_4; pfam01565 446465007337 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446465007338 putative acyl-acceptor binding pocket; other site 446465007339 classical (c) SDRs; Region: SDR_c; cd05233 446465007340 NAD(P) binding site [chemical binding]; other site 446465007341 active site 446465007342 fatty acyl-CoA reductase; Region: PLN02996 446465007343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007344 NAD(P) binding site [chemical binding]; other site 446465007345 active site 446465007346 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 446465007347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465007348 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446465007349 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465007350 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 446465007351 Walker A/P-loop; other site 446465007352 ATP binding site [chemical binding]; other site 446465007353 Q-loop/lid; other site 446465007354 ABC transporter signature motif; other site 446465007355 Walker B; other site 446465007356 D-loop; other site 446465007357 H-loop/switch region; other site 446465007358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007359 dimer interface [polypeptide binding]; other site 446465007360 conserved gate region; other site 446465007361 putative PBP binding loops; other site 446465007362 ABC-ATPase subunit interface; other site 446465007363 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446465007364 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 446465007365 substrate binding pocket [chemical binding]; other site 446465007366 membrane-bound complex binding site; other site 446465007367 hinge residues; other site 446465007368 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 446465007369 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465007370 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 446465007371 Walker A/P-loop; other site 446465007372 ATP binding site [chemical binding]; other site 446465007373 Q-loop/lid; other site 446465007374 ABC transporter signature motif; other site 446465007375 Walker B; other site 446465007376 D-loop; other site 446465007377 H-loop/switch region; other site 446465007378 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465007379 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465007380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007381 Walker A/P-loop; other site 446465007382 ATP binding site [chemical binding]; other site 446465007383 Q-loop/lid; other site 446465007384 ABC transporter signature motif; other site 446465007385 Walker B; other site 446465007386 D-loop; other site 446465007387 H-loop/switch region; other site 446465007388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465007389 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465007390 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465007391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007392 Walker A/P-loop; other site 446465007393 ATP binding site [chemical binding]; other site 446465007394 Q-loop/lid; other site 446465007395 ABC transporter signature motif; other site 446465007396 Walker B; other site 446465007397 D-loop; other site 446465007398 H-loop/switch region; other site 446465007399 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465007400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007401 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446465007402 Walker A/P-loop; other site 446465007403 ATP binding site [chemical binding]; other site 446465007404 Q-loop/lid; other site 446465007405 ABC transporter signature motif; other site 446465007406 Walker B; other site 446465007407 D-loop; other site 446465007408 H-loop/switch region; other site 446465007409 Protein of unknown function (DUF456); Region: DUF456; cl01069 446465007410 VanZ like family; Region: VanZ; cl01971 446465007411 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446465007412 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446465007413 dimer interface [polypeptide binding]; other site 446465007414 active site 446465007415 CoA binding pocket [chemical binding]; other site 446465007416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007417 Walker A/P-loop; other site 446465007418 ATP binding site [chemical binding]; other site 446465007419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007420 Q-loop/lid; other site 446465007421 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007422 ABC transporter signature motif; other site 446465007423 Walker B; other site 446465007424 D-loop; other site 446465007425 H-loop/switch region; other site 446465007426 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465007427 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 446465007428 active site 446465007429 metal binding site [ion binding]; metal-binding site 446465007430 DNA binding site [nucleotide binding] 446465007431 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 446465007432 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 446465007433 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446465007434 dimer interface [polypeptide binding]; other site 446465007435 substrate binding site [chemical binding]; other site 446465007436 ATP binding site [chemical binding]; other site 446465007437 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 446465007438 metabolite-proton symporter; Region: 2A0106; TIGR00883 446465007439 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 446465007440 substrate binding site [chemical binding]; other site 446465007441 multimerization interface [polypeptide binding]; other site 446465007442 ATP binding site [chemical binding]; other site 446465007443 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 446465007444 pyrophosphate binding site [ion binding]; other site 446465007445 active site 446465007446 thiamine phosphate binding site [chemical binding]; other site 446465007447 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465007448 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 446465007449 tetramerization interface [polypeptide binding]; other site 446465007450 NAD(P) binding site [chemical binding]; other site 446465007451 catalytic residues [active] 446465007452 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 446465007453 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 446465007454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465007455 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446465007456 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465007457 hydrophobic ligand binding site; other site 446465007458 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 446465007459 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465007460 active site 446465007461 metal binding site [ion binding]; metal-binding site 446465007462 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446465007463 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446465007464 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465007465 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 446465007466 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446465007467 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465007468 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465007469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465007470 ATP binding site [chemical binding]; other site 446465007471 Walker A motif; other site 446465007472 Walker B motif; other site 446465007473 arginine finger; other site 446465007474 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 446465007475 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 446465007476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465007477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465007478 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465007479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007480 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465007481 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 446465007482 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 446465007483 active site 446465007484 nucleophile elbow; other site 446465007485 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 446465007486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 446465007487 dimer interface [polypeptide binding]; other site 446465007488 phosphorylation site [posttranslational modification] 446465007489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465007490 ATP binding site [chemical binding]; other site 446465007491 Mg2+ binding site [ion binding]; other site 446465007492 G-X-G motif; other site 446465007493 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 446465007494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465007495 active site 446465007496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 446465007497 Response regulator receiver domain; Region: Response_reg; pfam00072 446465007498 active site 446465007499 phosphorylation site [posttranslational modification] 446465007500 intermolecular recognition site; other site 446465007501 dimerization interface [polypeptide binding]; other site 446465007502 HipA N-terminal domain; Region: couple_hipA; TIGR03071 446465007503 HipA-like N-terminal domain; Region: HipA_N; pfam07805 446465007504 HipA-like C-terminal domain; Region: HipA_C; pfam07804 446465007505 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446465007506 Peptidase family M23; Region: Peptidase_M23; pfam01551 446465007507 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007508 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465007509 DNA binding site [nucleotide binding] 446465007510 domain linker motif; other site 446465007511 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007512 ligand binding site [chemical binding]; other site 446465007513 dimerization interface [polypeptide binding]; other site 446465007514 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465007515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465007516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007517 dimer interface [polypeptide binding]; other site 446465007518 conserved gate region; other site 446465007519 putative PBP binding loops; other site 446465007520 ABC-ATPase subunit interface; other site 446465007521 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007523 dimer interface [polypeptide binding]; other site 446465007524 putative PBP binding loops; other site 446465007525 ABC-ATPase subunit interface; other site 446465007526 putative oxidoreductase; Provisional; Region: PRK11579 446465007527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007528 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465007529 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446465007530 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 446465007531 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 446465007532 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446465007533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465007534 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465007535 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446465007536 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 446465007537 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446465007538 homodimer interface [polypeptide binding]; other site 446465007539 substrate-cofactor binding pocket; other site 446465007540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465007541 catalytic residue [active] 446465007542 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446465007543 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465007544 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 446465007545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465007546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007547 dimer interface [polypeptide binding]; other site 446465007548 conserved gate region; other site 446465007549 putative PBP binding loops; other site 446465007550 ABC-ATPase subunit interface; other site 446465007551 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465007552 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 446465007553 Walker A/P-loop; other site 446465007554 ATP binding site [chemical binding]; other site 446465007555 Q-loop/lid; other site 446465007556 ABC transporter signature motif; other site 446465007557 Walker B; other site 446465007558 D-loop; other site 446465007559 H-loop/switch region; other site 446465007560 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465007561 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465007562 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446465007563 Walker A/P-loop; other site 446465007564 ATP binding site [chemical binding]; other site 446465007565 Q-loop/lid; other site 446465007566 ABC transporter signature motif; other site 446465007567 Walker B; other site 446465007568 D-loop; other site 446465007569 H-loop/switch region; other site 446465007570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465007571 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446465007572 active site 446465007573 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 446465007574 dimer interface [polypeptide binding]; other site 446465007575 non-prolyl cis peptide bond; other site 446465007576 insertion regions; other site 446465007577 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465007578 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446465007579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 446465007580 binding surface 446465007581 TPR motif; other site 446465007582 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465007583 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446465007584 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 446465007585 putative ADP-binding pocket [chemical binding]; other site 446465007586 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 446465007587 active site 446465007588 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465007589 active site 446465007590 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465007591 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446465007592 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446465007593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007594 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446465007595 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 446465007596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007597 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446465007598 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446465007599 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465007600 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 446465007601 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 446465007602 active site 446465007603 homodimer interface [polypeptide binding]; other site 446465007604 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465007605 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 446465007606 Walker A/P-loop; other site 446465007607 ATP binding site [chemical binding]; other site 446465007608 Q-loop/lid; other site 446465007609 ABC transporter signature motif; other site 446465007610 Walker B; other site 446465007611 D-loop; other site 446465007612 H-loop/switch region; other site 446465007613 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446465007614 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446465007615 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007616 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465007617 DNA binding site [nucleotide binding] 446465007618 domain linker motif; other site 446465007619 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007620 ligand binding site [chemical binding]; other site 446465007621 dimerization interface [polypeptide binding]; other site 446465007622 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 446465007623 putative active site [active] 446465007624 catalytic site [active] 446465007625 putative metal binding site [ion binding]; other site 446465007626 oligomer interface [polypeptide binding]; other site 446465007627 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 446465007628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465007629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007630 dimer interface [polypeptide binding]; other site 446465007631 conserved gate region; other site 446465007632 putative PBP binding loops; other site 446465007633 ABC-ATPase subunit interface; other site 446465007634 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446465007635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007636 Walker A/P-loop; other site 446465007637 ATP binding site [chemical binding]; other site 446465007638 Q-loop/lid; other site 446465007639 ABC transporter signature motif; other site 446465007640 Walker B; other site 446465007641 D-loop; other site 446465007642 H-loop/switch region; other site 446465007643 TOBE domain; Region: TOBE_2; cl01440 446465007644 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 446465007645 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465007646 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 446465007647 MgtC family; Region: MgtC; cl12207 446465007648 Divergent AAA domain; Region: AAA_4; pfam04326 446465007649 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 446465007650 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 446465007651 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 446465007652 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446465007653 dimer interface [polypeptide binding]; other site 446465007654 putative radical transfer pathway; other site 446465007655 diiron center [ion binding]; other site 446465007656 tyrosyl radical; other site 446465007657 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 446465007658 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 446465007659 putative homotetramer interface [polypeptide binding]; other site 446465007660 putative homodimer interface [polypeptide binding]; other site 446465007661 putative allosteric switch controlling residues; other site 446465007662 putative metal binding site [ion binding]; other site 446465007663 putative homodimer-homodimer interface [polypeptide binding]; other site 446465007664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465007665 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446465007666 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446465007667 active site residue [active] 446465007668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465007669 Coenzyme A binding pocket [chemical binding]; other site 446465007670 Sulfatase; Region: Sulfatase; cl10460 446465007671 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465007672 L-idonate 5-dehydrogenase; Region: PLN02702 446465007673 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 446465007674 inhibitor binding site; inhibition site 446465007675 catalytic Zn binding site [ion binding]; other site 446465007676 structural Zn binding site [ion binding]; other site 446465007677 NADP binding site [chemical binding]; other site 446465007678 tetramer interface [polypeptide binding]; other site 446465007679 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 446465007680 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 446465007681 trimer interface [polypeptide binding]; other site 446465007682 putative metal binding site [ion binding]; other site 446465007683 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465007684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465007685 putative substrate translocation pore; other site 446465007686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465007687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465007688 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465007689 active site 446465007690 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446465007691 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 446465007692 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 446465007693 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465007694 active site 446465007695 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 446465007696 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a...; Region: PGM_like2; cd05800 446465007697 active site 446465007698 substrate binding site [chemical binding]; other site 446465007699 metal binding site [ion binding]; metal-binding site 446465007700 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465007701 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465007702 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446465007703 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 446465007704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465007705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465007706 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 446465007707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007708 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 446465007709 aspartate kinase; Reviewed; Region: PRK06635 446465007710 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 446465007711 putative nucleotide binding site [chemical binding]; other site 446465007712 putative catalytic residues [active] 446465007713 putative Mg ion binding site [ion binding]; other site 446465007714 putative aspartate binding site [chemical binding]; other site 446465007715 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 446465007716 putative allosteric regulatory site; other site 446465007717 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 446465007718 putative allosteric regulatory residue; other site 446465007719 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007720 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465007721 DNA binding site [nucleotide binding] 446465007722 domain linker motif; other site 446465007723 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007724 dimerization interface [polypeptide binding]; other site 446465007725 ligand binding site [chemical binding]; other site 446465007726 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 446465007727 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 446465007728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465007729 putative substrate translocation pore; other site 446465007730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465007731 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446465007732 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 446465007733 multimer interface [polypeptide binding]; other site 446465007734 active site 446465007735 catalytic triad [active] 446465007736 protein interface 1 [polypeptide binding]; other site 446465007737 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 446465007738 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 446465007739 homodimer interface [polypeptide binding]; other site 446465007740 NAD binding pocket [chemical binding]; other site 446465007741 ATP binding pocket [chemical binding]; other site 446465007742 Mg binding site [ion binding]; other site 446465007743 active-site loop [active] 446465007744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007745 dimer interface [polypeptide binding]; other site 446465007746 conserved gate region; other site 446465007747 putative PBP binding loops; other site 446465007748 ABC-ATPase subunit interface; other site 446465007749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007750 dimer interface [polypeptide binding]; other site 446465007751 conserved gate region; other site 446465007752 putative PBP binding loops; other site 446465007753 ABC-ATPase subunit interface; other site 446465007754 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465007755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465007756 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446465007757 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446465007758 Walker A/P-loop; other site 446465007759 ATP binding site [chemical binding]; other site 446465007760 Q-loop/lid; other site 446465007761 ABC transporter signature motif; other site 446465007762 Walker B; other site 446465007763 D-loop; other site 446465007764 H-loop/switch region; other site 446465007765 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446465007766 recombination protein RecR; Reviewed; Region: recR; PRK00076 446465007767 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446465007768 RecR protein; Region: RecR; pfam02132 446465007769 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 446465007770 putative active site [active] 446465007771 putative metal-binding site [ion binding]; other site 446465007772 tetramer interface [polypeptide binding]; other site 446465007773 Integrase core domain; Region: rve; cl01316 446465007774 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 446465007775 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 446465007776 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 446465007777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 446465007778 Walker A motif; other site 446465007779 ATP binding site [chemical binding]; other site 446465007780 Walker B motif; other site 446465007781 arginine finger; other site 446465007782 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 446465007783 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446465007784 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 446465007785 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465007786 hydrophobic ligand binding site; other site 446465007787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007788 TIGR01777 family protein; Region: yfcH 446465007789 NAD(P) binding site [chemical binding]; other site 446465007790 active site 446465007791 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 446465007792 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 446465007793 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 446465007794 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446465007795 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446465007796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465007797 active site 446465007798 catalytic tetrad [active] 446465007799 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 446465007800 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465007801 NAD(P) binding site [chemical binding]; other site 446465007802 catalytic residues [active] 446465007803 Protein of unknown function (DUF779); Region: DUF779; cl01432 446465007804 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 446465007805 Cupin domain; Region: Cupin_2; cl09118 446465007806 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446465007807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465007808 galactoside permease; Reviewed; Region: lacY; PRK09528 446465007809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465007810 putative substrate translocation pore; other site 446465007811 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 446465007812 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 446465007813 active site 446465007814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465007815 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465007816 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465007817 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 446465007818 Walker A/P-loop; other site 446465007819 ATP binding site [chemical binding]; other site 446465007820 Q-loop/lid; other site 446465007821 ABC transporter signature motif; other site 446465007822 Walker B; other site 446465007823 D-loop; other site 446465007824 H-loop/switch region; other site 446465007825 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465007826 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446465007827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465007828 Walker A/P-loop; other site 446465007829 ATP binding site [chemical binding]; other site 446465007830 Q-loop/lid; other site 446465007831 ABC transporter signature motif; other site 446465007832 Walker B; other site 446465007833 D-loop; other site 446465007834 H-loop/switch region; other site 446465007835 LrgB-like family; Region: LrgB; cl00596 446465007836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465007837 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 446465007838 amidohydrolase; Region: amidohydrolases; TIGR01891 446465007839 metal binding site [ion binding]; metal-binding site 446465007840 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 446465007841 Golgin subfamily A member 7/ERF4 family; Region: Erf4; pfam10256 446465007842 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465007843 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 446465007844 Walker A/P-loop; other site 446465007845 ATP binding site [chemical binding]; other site 446465007846 Q-loop/lid; other site 446465007847 ABC transporter signature motif; other site 446465007848 Walker B; other site 446465007849 D-loop; other site 446465007850 H-loop/switch region; other site 446465007851 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 446465007852 Walker A/P-loop; other site 446465007853 ATP binding site [chemical binding]; other site 446465007854 Q-loop/lid; other site 446465007855 ABC transporter signature motif; other site 446465007856 Walker B; other site 446465007857 D-loop; other site 446465007858 H-loop/switch region; other site 446465007859 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446465007860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465007861 motif II; other site 446465007862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 446465007863 motif II; other site 446465007864 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007865 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007866 ligand binding site [chemical binding]; other site 446465007867 dimerization interface [polypeptide binding]; other site 446465007868 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446465007869 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465007870 active site 446465007871 nucleotide binding site [chemical binding]; other site 446465007872 HIGH motif; other site 446465007873 KMSKS motif; other site 446465007874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 446465007875 FeS/SAM binding site; other site 446465007876 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446465007877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465007878 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446465007879 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465007880 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465007881 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 446465007882 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 446465007883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 446465007884 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465007885 Sulfatase; Region: Sulfatase; cl10460 446465007886 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465007887 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446465007888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007889 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007890 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465007891 DNA binding site [nucleotide binding] 446465007892 domain linker motif; other site 446465007893 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007894 dimerization interface [polypeptide binding]; other site 446465007895 ligand binding site [chemical binding]; other site 446465007896 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446465007897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465007899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007900 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007901 ligand binding site [chemical binding]; other site 446465007902 dimerization interface [polypeptide binding]; other site 446465007903 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465007904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465007905 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446465007906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007907 dimer interface [polypeptide binding]; other site 446465007908 conserved gate region; other site 446465007909 putative PBP binding loops; other site 446465007910 ABC-ATPase subunit interface; other site 446465007911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007913 dimer interface [polypeptide binding]; other site 446465007914 conserved gate region; other site 446465007915 putative PBP binding loops; other site 446465007916 ABC-ATPase subunit interface; other site 446465007917 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 446465007918 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465007919 Protein of unknown function (DUF993); Region: DUF993; pfam06187 446465007920 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465007921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007922 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 446465007923 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 446465007924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465007925 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 446465007926 active site 446465007927 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446465007928 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465007929 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446465007930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465007931 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007933 dimer interface [polypeptide binding]; other site 446465007934 conserved gate region; other site 446465007935 putative PBP binding loops; other site 446465007936 ABC-ATPase subunit interface; other site 446465007937 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 446465007938 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 446465007939 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465007940 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 446465007941 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465007942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007943 dimer interface [polypeptide binding]; other site 446465007944 conserved gate region; other site 446465007945 ABC-ATPase subunit interface; other site 446465007946 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 446465007947 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 446465007948 active site 446465007949 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465007951 DNA binding site [nucleotide binding] 446465007952 domain linker motif; other site 446465007953 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007954 dimerization interface [polypeptide binding]; other site 446465007955 ligand binding site [chemical binding]; other site 446465007956 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 446465007957 active site 446465007958 catalytic triad [active] 446465007959 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465007960 hexulose-6-phosphate isomerase, putative; Region: hxl6Piso_put; TIGR00542 446465007961 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446465007962 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 446465007963 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446465007964 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 446465007965 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 446465007966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465007968 DNA binding site [nucleotide binding] 446465007969 domain linker motif; other site 446465007970 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007971 dimerization interface [polypeptide binding]; other site 446465007972 ligand binding site [chemical binding]; other site 446465007973 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465007974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465007975 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465007976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007977 dimer interface [polypeptide binding]; other site 446465007978 conserved gate region; other site 446465007979 putative PBP binding loops; other site 446465007980 ABC-ATPase subunit interface; other site 446465007981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465007982 dimer interface [polypeptide binding]; other site 446465007983 conserved gate region; other site 446465007984 putative PBP binding loops; other site 446465007985 ABC-ATPase subunit interface; other site 446465007986 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465007987 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465007988 DNA binding site [nucleotide binding] 446465007989 domain linker motif; other site 446465007990 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465007991 dimerization interface [polypeptide binding]; other site 446465007992 ligand binding site [chemical binding]; other site 446465007993 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 446465007994 dimerization interface [polypeptide binding]; other site 446465007995 active site 446465007996 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 446465007997 folate binding site [chemical binding]; other site 446465007998 NADP+ binding site [chemical binding]; other site 446465007999 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 446465008000 substrate binding site [chemical binding]; other site 446465008001 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 446465008002 active site 446465008003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008004 dimer interface [polypeptide binding]; other site 446465008005 conserved gate region; other site 446465008006 putative PBP binding loops; other site 446465008007 ABC-ATPase subunit interface; other site 446465008008 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446465008009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465008010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008011 putative PBP binding loops; other site 446465008012 dimer interface [polypeptide binding]; other site 446465008013 ABC-ATPase subunit interface; other site 446465008014 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008015 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008017 dimer interface [polypeptide binding]; other site 446465008018 conserved gate region; other site 446465008019 putative PBP binding loops; other site 446465008020 ABC-ATPase subunit interface; other site 446465008021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008022 dimer interface [polypeptide binding]; other site 446465008023 conserved gate region; other site 446465008024 putative PBP binding loops; other site 446465008025 ABC-ATPase subunit interface; other site 446465008026 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465008028 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446465008029 TM-ABC transporter signature motif; other site 446465008030 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 446465008031 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 446465008032 Walker A/P-loop; other site 446465008033 ATP binding site [chemical binding]; other site 446465008034 Q-loop/lid; other site 446465008035 ABC transporter signature motif; other site 446465008036 Walker B; other site 446465008037 D-loop; other site 446465008038 H-loop/switch region; other site 446465008039 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 446465008040 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446465008041 putative ligand binding site [chemical binding]; other site 446465008042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008044 DNA binding site [nucleotide binding] 446465008045 domain linker motif; other site 446465008046 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465008047 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465008048 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 446465008049 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 446465008050 intersubunit interface [polypeptide binding]; other site 446465008051 active site 446465008052 Zn2+ binding site [ion binding]; other site 446465008053 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 446465008054 Sulfatase; Region: Sulfatase; cl10460 446465008055 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 446465008056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465008057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446465008058 dimerization interface [polypeptide binding]; other site 446465008059 L-arabinose isomerase; Provisional; Region: PRK02929 446465008060 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947 446465008061 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446465008062 trimer interface [polypeptide binding]; other site 446465008063 substrate binding site [chemical binding]; other site 446465008064 Mn binding site [ion binding]; other site 446465008065 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446465008066 FAD binding domain; Region: FAD_binding_4; pfam01565 446465008067 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 446465008068 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 446465008069 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446465008070 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465008071 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465008072 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 446465008073 Domain of unknown function (DUF718); Region: DUF718; cl01281 446465008074 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 446465008075 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 446465008076 short chain dehydrogenase; Validated; Region: PRK08324 446465008077 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 446465008078 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 446465008079 putative NAD(P) binding site [chemical binding]; other site 446465008080 active site 446465008081 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 446465008082 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465008083 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 446465008084 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008086 DNA binding site [nucleotide binding] 446465008087 domain linker motif; other site 446465008088 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008089 dimerization interface [polypeptide binding]; other site 446465008090 ligand binding site [chemical binding]; other site 446465008091 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 446465008092 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 446465008093 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465008094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008096 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465008097 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008099 dimer interface [polypeptide binding]; other site 446465008100 conserved gate region; other site 446465008101 putative PBP binding loops; other site 446465008102 ABC-ATPase subunit interface; other site 446465008103 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465008104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008105 dimer interface [polypeptide binding]; other site 446465008106 putative PBP binding loops; other site 446465008107 ABC-ATPase subunit interface; other site 446465008108 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465008110 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008111 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465008112 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 446465008113 LamB/YcsF family; Region: LamB_YcsF; cl00664 446465008114 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 446465008115 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 446465008116 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 446465008117 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 446465008118 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 446465008119 benzoate transport; Region: 2A0115; TIGR00895 446465008120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008121 putative substrate translocation pore; other site 446465008122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008123 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 446465008124 dihydroxyacetone kinase; Provisional; Region: PRK14479 446465008125 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446465008126 DAK2 domain; Region: Dak2; cl03685 446465008127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008128 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465008129 NAD(P) binding site [chemical binding]; other site 446465008130 active site 446465008131 polyol permease family; Region: 2A0118; TIGR00897 446465008132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008133 putative substrate translocation pore; other site 446465008134 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465008135 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 446465008136 NAD(P) binding site [chemical binding]; other site 446465008137 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 446465008138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 446465008139 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 446465008140 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465008141 D-xylulose kinase; Region: XylB; TIGR01312 446465008142 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 446465008143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465008145 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008147 dimer interface [polypeptide binding]; other site 446465008148 conserved gate region; other site 446465008149 putative PBP binding loops; other site 446465008150 ABC-ATPase subunit interface; other site 446465008151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465008152 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446465008153 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446465008154 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446465008155 Sodium:solute symporter family; Region: SSF; cl00456 446465008156 glycerol kinase; Provisional; Region: glpK; PRK00047 446465008157 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465008158 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 446465008159 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 446465008160 amphipathic channel; other site 446465008161 Asn-Pro-Ala signature motifs; other site 446465008162 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446465008163 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 446465008164 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 446465008165 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 446465008166 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465008167 hydrophobic ligand binding site; other site 446465008168 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 446465008169 putative hydrophobic ligand binding site [chemical binding]; other site 446465008170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465008171 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 446465008172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446465008173 dimerization interface [polypeptide binding]; other site 446465008174 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446465008175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465008176 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446465008177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465008178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 446465008179 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465008180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465008181 Walker A/P-loop; other site 446465008182 ATP binding site [chemical binding]; other site 446465008183 Q-loop/lid; other site 446465008184 ABC transporter signature motif; other site 446465008185 Walker B; other site 446465008186 D-loop; other site 446465008187 H-loop/switch region; other site 446465008188 TIGR03442 family protein; Region: TIGR03442 446465008189 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 446465008190 putative active site [active] 446465008191 putative dimer interface [polypeptide binding]; other site 446465008192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008193 dimer interface [polypeptide binding]; other site 446465008194 conserved gate region; other site 446465008195 putative PBP binding loops; other site 446465008196 ABC-ATPase subunit interface; other site 446465008197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008198 dimer interface [polypeptide binding]; other site 446465008199 conserved gate region; other site 446465008200 putative PBP binding loops; other site 446465008201 ABC-ATPase subunit interface; other site 446465008202 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 446465008203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 446465008204 substrate binding pocket [chemical binding]; other site 446465008205 membrane-bound complex binding site; other site 446465008206 hinge residues; other site 446465008207 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465008208 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 446465008209 Walker A/P-loop; other site 446465008210 ATP binding site [chemical binding]; other site 446465008211 Q-loop/lid; other site 446465008212 ABC transporter signature motif; other site 446465008213 Walker B; other site 446465008214 D-loop; other site 446465008215 H-loop/switch region; other site 446465008216 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 446465008217 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446465008218 dimer interface [polypeptide binding]; other site 446465008219 substrate binding site [chemical binding]; other site 446465008220 ATP binding site [chemical binding]; other site 446465008221 GtrA-like protein; Region: GtrA; cl00971 446465008222 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 446465008223 putative ADP-ribose binding site [chemical binding]; other site 446465008224 putative active site [active] 446465008225 hypothetical protein; Provisional; Region: PRK08912 446465008226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465008227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465008228 homodimer interface [polypeptide binding]; other site 446465008229 catalytic residue [active] 446465008230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 446465008231 substrate binding site [chemical binding]; other site 446465008232 oxyanion hole (OAH) forming residues; other site 446465008233 trimer interface [polypeptide binding]; other site 446465008234 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 446465008235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008236 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446465008237 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465008238 hydrophobic ligand binding site; other site 446465008239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465008240 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446465008241 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 446465008242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465008243 catalytic residue [active] 446465008244 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 446465008245 Peptidase M66; Region: Peptidase_M66; pfam10462 446465008246 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 446465008247 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446465008248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465008249 active site 446465008250 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 446465008251 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446465008252 dimer interface [polypeptide binding]; other site 446465008253 active site 446465008254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465008255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465008256 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 446465008257 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446465008258 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446465008259 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 446465008260 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446465008261 active site 446465008262 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 446465008263 catalytic triad [active] 446465008264 Beta-lactamase; Region: Beta-lactamase; cl01009 446465008265 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 446465008266 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 446465008267 active site 446465008268 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 446465008269 catalytic residues [active] 446465008270 dimer interface [polypeptide binding]; other site 446465008271 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446465008272 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465008273 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 446465008274 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 446465008275 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 446465008276 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465008277 Ligand Binding Site [chemical binding]; other site 446465008278 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 446465008279 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 446465008280 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465008281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465008282 active site 446465008283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465008284 catalytic tetrad [active] 446465008285 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 446465008286 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446465008287 Walker A/P-loop; other site 446465008288 ATP binding site [chemical binding]; other site 446465008289 Q-loop/lid; other site 446465008290 ABC transporter signature motif; other site 446465008291 Walker B; other site 446465008292 D-loop; other site 446465008293 H-loop/switch region; other site 446465008294 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 446465008295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 446465008296 ABC-ATPase subunit interface; other site 446465008297 dimer interface [polypeptide binding]; other site 446465008298 putative PBP binding regions; other site 446465008299 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 446465008300 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 446465008301 ABC-ATPase subunit interface; other site 446465008302 dimer interface [polypeptide binding]; other site 446465008303 putative PBP binding regions; other site 446465008304 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 446465008305 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446465008306 intersubunit interface [polypeptide binding]; other site 446465008307 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 446465008308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 446465008309 S-adenosylmethionine binding site [chemical binding]; other site 446465008310 hypothetical membrane protein, TIGR01666; Region: YCCS 446465008311 Sodium:solute symporter family; Region: SSF; cl00456 446465008312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465008313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465008314 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446465008315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 446465008316 Walker A/P-loop; other site 446465008317 ATP binding site [chemical binding]; other site 446465008318 Q-loop/lid; other site 446465008319 ABC transporter signature motif; other site 446465008320 Walker B; other site 446465008321 D-loop; other site 446465008322 H-loop/switch region; other site 446465008323 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446465008324 Isochorismatase family; Region: Isochorismatase; pfam00857 446465008325 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446465008326 catalytic triad [active] 446465008327 conserved cis-peptide bond; other site 446465008328 Protein of unknown function, DUF488; Region: DUF488; cl01246 446465008329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008330 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 446465008331 NAD(P) binding site [chemical binding]; other site 446465008332 active site 446465008333 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 446465008334 active site 446465008335 Zn binding site [ion binding]; other site 446465008336 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 446465008337 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 446465008338 active sites [active] 446465008339 tetramer interface [polypeptide binding]; other site 446465008340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 446465008341 Nucleoside recognition; Region: Gate; cl00486 446465008342 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446465008343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 446465008344 active site 446465008345 urocanate hydratase; Provisional; Region: PRK05414 446465008346 urocanate hydratase; Region: hutU; TIGR01228 446465008347 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465008348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465008349 short chain dehydrogenase; Provisional; Region: PRK06139 446465008350 Arginase family; Region: Arginase; cl00306 446465008351 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446465008352 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465008353 substrate binding site [chemical binding]; other site 446465008354 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465008355 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 446465008356 glutamate dehydrogenase; Provisional; Region: PRK09414 446465008357 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 446465008358 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 446465008359 NAD(P) binding site [chemical binding]; other site 446465008360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008361 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446465008362 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 446465008363 active site 446465008364 catalytic site [active] 446465008365 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446465008366 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 446465008367 active site 446465008368 catalytic site [active] 446465008369 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465008371 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008373 dimer interface [polypeptide binding]; other site 446465008374 conserved gate region; other site 446465008375 putative PBP binding loops; other site 446465008376 ABC-ATPase subunit interface; other site 446465008377 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465008378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 446465008379 dimer interface [polypeptide binding]; other site 446465008380 conserved gate region; other site 446465008381 putative PBP binding loops; other site 446465008382 ABC-ATPase subunit interface; other site 446465008383 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008384 DNA binding site [nucleotide binding] 446465008385 domain linker motif; other site 446465008386 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008387 ligand binding site [chemical binding]; other site 446465008388 dimerization interface [polypeptide binding]; other site 446465008389 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 446465008390 Ferritin-like domain; Region: Ferritin; pfam00210 446465008391 ferroxidase diiron center [ion binding]; other site 446465008392 BCCT family transporter; Region: BCCT; cl00569 446465008393 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465008394 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 446465008395 Predicted membrane protein [Function unknown]; Region: COG2311 446465008396 Protein of unknown function (DUF418); Region: DUF418; cl12135 446465008397 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446465008398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465008399 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446465008400 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465008401 putative catalytic site [active] 446465008402 putative metal binding site [ion binding]; other site 446465008403 putative phosphate binding site [ion binding]; other site 446465008404 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 446465008405 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 446465008406 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 446465008407 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 446465008408 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 446465008409 protein binding site [polypeptide binding]; other site 446465008410 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 446465008411 Domain interface; other site 446465008412 Peptide binding site; other site 446465008413 Active site tetrad [active] 446465008414 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465008415 hydrophobic ligand binding site; other site 446465008416 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446465008417 Protein of unknown function (DUF461); Region: DUF461; cl01071 446465008418 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446465008419 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 446465008420 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465008421 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 446465008422 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 446465008423 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446465008424 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446465008425 Glucuronate isomerase; Region: UxaC; cl00829 446465008426 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 446465008427 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008428 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008429 DNA binding site [nucleotide binding] 446465008430 domain linker motif; other site 446465008431 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008432 ligand binding site [chemical binding]; other site 446465008433 dimerization interface [polypeptide binding]; other site 446465008434 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 446465008435 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 446465008436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465008437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465008438 AIR carboxylase; Region: AIRC; cl00310 446465008439 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 446465008440 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 446465008441 Ligand Binding Site [chemical binding]; other site 446465008442 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 446465008443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465008444 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 446465008445 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446465008446 Active site [active] 446465008447 Membrane transport protein; Region: Mem_trans; cl09117 446465008448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465008449 dimerization interface [polypeptide binding]; other site 446465008450 putative DNA binding site [nucleotide binding]; other site 446465008451 putative Zn2+ binding site [ion binding]; other site 446465008452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465008453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446465008454 cyanate transporter; Region: CynX; TIGR00896 446465008455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008456 putative substrate translocation pore; other site 446465008457 Cupin domain; Region: Cupin_2; cl09118 446465008458 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 446465008459 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 446465008460 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465008461 active site 446465008462 catalytic tetrad [active] 446465008463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 446465008464 sugar efflux transporter B; Provisional; Region: PRK15011 446465008465 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465008466 classical (c) SDRs; Region: SDR_c; cd05233 446465008467 NAD(P) binding site [chemical binding]; other site 446465008468 active site 446465008469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446465008470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465008471 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 446465008472 putative acyltransferase; Provisional; Region: PRK05790 446465008473 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446465008474 dimer interface [polypeptide binding]; other site 446465008475 active site 446465008476 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 446465008477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 446465008478 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446465008479 FeoA domain; Region: FeoA; cl00838 446465008480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 446465008481 dimer interface [polypeptide binding]; other site 446465008482 putative PBP binding regions; other site 446465008483 ABC-ATPase subunit interface; other site 446465008484 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446465008485 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 446465008486 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 446465008487 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446465008488 metal binding site [ion binding]; metal-binding site 446465008489 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446465008490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465008491 DNA-binding site [nucleotide binding]; DNA binding site 446465008492 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465008493 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 446465008494 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 446465008495 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446465008496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 446465008497 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446465008498 dimer interface [polypeptide binding]; other site 446465008499 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 446465008500 active site clefts [active] 446465008501 zinc binding site [ion binding]; other site 446465008502 dimer interface [polypeptide binding]; other site 446465008503 aminodeoxychorismate synthase; Provisional; Region: PRK07508 446465008504 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446465008505 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 446465008506 homodimer interface [polypeptide binding]; other site 446465008507 substrate-cofactor binding pocket; other site 446465008508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465008509 catalytic residue [active] 446465008510 Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398 446465008511 Protein of unknown function DUF111; Region: DUF111; pfam01969 446465008512 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 446465008513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 446465008514 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 446465008515 Domain of unknown function DUF21; Region: DUF21; pfam01595 446465008516 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446465008517 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446465008518 Domain of unknown function DUF21; Region: DUF21; pfam01595 446465008519 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446465008520 Transporter associated domain; Region: CorC_HlyC; pfam03471 446465008521 Predicted esterase [General function prediction only]; Region: COG0400 446465008522 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465008523 RNA polymerase I specific transcription initiation factor RRN3; Region: RRN3; pfam05327 446465008524 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 446465008525 proposed catalytic triad [active] 446465008526 conserved cys residue [active] 446465008527 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 446465008528 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 446465008529 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 446465008530 Proline racemase; Region: Pro_racemase; pfam05544 446465008531 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465008532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465008533 DNA-binding site [nucleotide binding]; DNA binding site 446465008534 FCD domain; Region: FCD; cl11656 446465008535 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446465008536 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 446465008537 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 446465008538 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 446465008539 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 446465008540 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465008541 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446465008542 NAD(P) binding site [chemical binding]; other site 446465008543 catalytic residues [active] 446465008544 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446465008545 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446465008546 inhibitor site; inhibition site 446465008547 active site 446465008548 dimer interface [polypeptide binding]; other site 446465008549 catalytic residue [active] 446465008550 Predicted transcriptional regulators [Transcription]; Region: COG1510 446465008551 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465008552 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446465008553 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465008554 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465008555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008556 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446465008557 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 446465008558 active site 446465008559 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 446465008560 putative metal binding site [ion binding]; other site 446465008561 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446465008562 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465008563 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446465008564 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 446465008565 Amino acid permease; Region: AA_permease; pfam00324 446465008566 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 446465008567 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 446465008568 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 446465008569 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 446465008570 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 446465008571 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446465008572 dimer interface [polypeptide binding]; other site 446465008573 ssDNA binding site [nucleotide binding]; other site 446465008574 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446465008575 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 446465008576 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 446465008577 hydroperoxidase II; Provisional; Region: katE; PRK11249 446465008578 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 446465008579 heme binding pocket [chemical binding]; other site 446465008580 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 446465008581 domain interactions; other site 446465008582 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 446465008583 Transglycosylase; Region: Transgly; cl07896 446465008584 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 446465008585 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 446465008586 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 446465008587 active site 446465008588 NTP binding site [chemical binding]; other site 446465008589 metal binding triad [ion binding]; metal-binding site 446465008590 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 446465008591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 446465008592 MviN-like protein; Region: MVIN; pfam03023 446465008593 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 446465008594 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 446465008595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 446465008596 ParB-like partition proteins; Region: parB_part; TIGR00180 446465008597 ParB-like nuclease domain; Region: ParBc; cl02129 446465008598 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446465008599 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 446465008600 P-loop; other site 446465008601 Magnesium ion binding site [ion binding]; other site 446465008602 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 446465008603 Magnesium ion binding site [ion binding]; other site 446465008604 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 446465008605 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 446465008606 G-X-X-G motif; other site 446465008607 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 446465008608 RxxxH motif; other site 446465008609 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 446465008610 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 446465008611 Domain of unknown function DUF37; Region: DUF37; cl00506 446465008612 Ribonuclease P; Region: Ribonuclease_P; cl00457 446465008613 Ribosomal protein L34; Region: Ribosomal_L34; cl00370