-- dump date   	20120504_135329
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
483179000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
483179000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
483179000003	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179000004	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
483179000005	DnaA box-binding interface [nucleotide binding]; other site
483179000006	DNA polymerase III subunit beta; Validated; Region: PRK05643
483179000007	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
483179000008	putative DNA binding surface [nucleotide binding]; other site
483179000009	dimer interface [polypeptide binding]; other site
483179000010	beta-clamp/clamp loader binding surface; other site
483179000011	beta-clamp/translesion DNA polymerase binding surface; other site
483179000012	recombination protein F; Reviewed; Region: recF; PRK00064
483179000013	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
483179000014	Walker A/P-loop; other site
483179000015	ATP binding site [chemical binding]; other site
483179000016	Q-loop/lid; other site
483179000017	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179000018	ABC transporter signature motif; other site
483179000019	Walker B; other site
483179000020	D-loop; other site
483179000021	H-loop/switch region; other site
483179000022	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
483179000023	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
483179000024	ATP binding site [chemical binding]; other site
483179000025	substrate interface [chemical binding]; other site
483179000026	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
483179000027	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179000028	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
483179000029	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179000030	Walker A/P-loop; other site
483179000031	ATP binding site [chemical binding]; other site
483179000032	Q-loop/lid; other site
483179000033	ABC transporter signature motif; other site
483179000034	Walker B; other site
483179000035	D-loop; other site
483179000036	H-loop/switch region; other site
483179000037	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179000038	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179000039	Walker A/P-loop; other site
483179000040	ATP binding site [chemical binding]; other site
483179000041	Q-loop/lid; other site
483179000042	ABC transporter signature motif; other site
483179000043	Walker B; other site
483179000044	D-loop; other site
483179000045	H-loop/switch region; other site
483179000046	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179000047	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
483179000048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179000049	dimer interface [polypeptide binding]; other site
483179000050	conserved gate region; other site
483179000051	putative PBP binding loops; other site
483179000052	ABC-ATPase subunit interface; other site
483179000053	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
483179000054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179000055	dimer interface [polypeptide binding]; other site
483179000056	conserved gate region; other site
483179000057	putative PBP binding loops; other site
483179000058	ABC-ATPase subunit interface; other site
483179000059	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
483179000060	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
483179000061	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
483179000062	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
483179000063	leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404
483179000064	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
483179000065	dimerization interface [polypeptide binding]; other site
483179000066	ligand binding site [chemical binding]; other site
483179000067	enoyl-CoA hydratase; Provisional; Region: PRK07468
483179000068	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
483179000069	substrate binding site [chemical binding]; other site
483179000070	oxyanion hole (OAH) forming residues; other site
483179000071	trimer interface [polypeptide binding]; other site
483179000072	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
483179000073	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
483179000074	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179000075	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
483179000076	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
483179000077	carboxyltransferase (CT) interaction site; other site
483179000078	biotinylation site [posttranslational modification]; other site
483179000079	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
483179000080	isovaleryl-CoA dehydrogenase; Region: PLN02519
483179000081	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
483179000082	substrate binding site [chemical binding]; other site
483179000083	FAD binding site [chemical binding]; other site
483179000084	catalytic base [active]
483179000085	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
483179000086	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
483179000087	AMP-binding enzyme; Region: AMP-binding; cl15778
483179000088	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179000089	CHRD domain; Region: CHRD; cl06473
483179000090	OpgC protein; Region: OpgC_C; cl00792
483179000091	Acyltransferase family; Region: Acyl_transf_3; pfam01757
483179000092	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
483179000093	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
483179000094	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
483179000095	hinge; other site
483179000096	active site
483179000097	cytidylate kinase; Provisional; Region: cmk; PRK00023
483179000098	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
483179000099	CMP-binding site; other site
483179000100	The sites determining sugar specificity; other site
483179000101	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
483179000102	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
483179000103	RNA binding site [nucleotide binding]; other site
483179000104	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
483179000105	RNA binding site [nucleotide binding]; other site
483179000106	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
483179000107	RNA binding site [nucleotide binding]; other site
483179000108	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
483179000109	RNA binding site [nucleotide binding]; other site
483179000110	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
483179000111	RNA binding site [nucleotide binding]; other site
483179000112	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
483179000113	RNA binding site [nucleotide binding]; other site
483179000114	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
483179000115	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
483179000116	Helix-turn-helix domains; Region: HTH; cl00088
483179000117	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
483179000118	putative dimerization interface [polypeptide binding]; other site
483179000119	lytic murein transglycosylase; Region: MltB_2; TIGR02283
483179000120	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
483179000121	N-acetyl-D-glucosamine binding site [chemical binding]; other site
483179000122	recombination protein RecR; Reviewed; Region: recR; PRK00076
483179000123	RecR protein; Region: RecR; pfam02132
483179000124	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
483179000125	putative active site [active]
483179000126	putative metal-binding site [ion binding]; other site
483179000127	tetramer interface [polypeptide binding]; other site
483179000128	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
483179000129	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
483179000130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179000131	Walker A motif; other site
483179000132	ATP binding site [chemical binding]; other site
483179000133	Walker B motif; other site
483179000134	arginine finger; other site
483179000135	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
483179000136	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
483179000137	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
483179000138	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
483179000139	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
483179000140	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
483179000141	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
483179000142	putative NADH binding site [chemical binding]; other site
483179000143	putative active site [active]
483179000144	nudix motif; other site
483179000145	putative metal binding site [ion binding]; other site
483179000146	prephenate dehydratase; Provisional; Region: PRK11899
483179000147	Prephenate dehydratase; Region: PDT; pfam00800
483179000148	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
483179000149	putative L-Phe binding site [chemical binding]; other site
483179000150	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
483179000151	Ligand binding site; other site
483179000152	oligomer interface; other site
483179000153	Cytochrome c; Region: Cytochrom_C; cl11414
483179000154	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
483179000155	putative MPT binding site; other site
483179000156	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
483179000157	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179000158	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
483179000159	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
483179000160	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
483179000161	D-pathway; other site
483179000162	Putative ubiquinol binding site [chemical binding]; other site
483179000163	Low-spin heme (heme b) binding site [chemical binding]; other site
483179000164	Putative water exit pathway; other site
483179000165	Binuclear center (heme o3/CuB) [ion binding]; other site
483179000166	K-pathway; other site
483179000167	Putative proton exit pathway; other site
483179000168	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
483179000169	Subunit I/III interface [polypeptide binding]; other site
483179000170	Subunit III/IV interface [polypeptide binding]; other site
483179000171	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
483179000172	Bacterial SH3 domain; Region: SH3_3; cl02551
483179000173	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
483179000174	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
483179000175	Surface antigen; Region: Bac_surface_Ag; cl03097
483179000176	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
483179000177	Family of unknown function (DUF490); Region: DUF490; pfam04357
483179000178	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179000179	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
483179000180	Protein of unknown function (DUF461); Region: DUF461; cl01071
483179000181	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
483179000182	dimer interface [polypeptide binding]; other site
483179000183	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179000184	active site
483179000185	metal binding site [ion binding]; metal-binding site
483179000186	glutathione binding site [chemical binding]; other site
483179000187	Domain of unknown function DUF59; Region: DUF59; cl00941
483179000188	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
483179000189	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
483179000190	Walker A motif; other site
483179000191	phosphoglucomutase; Region: PLN02307
483179000192	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
483179000193	substrate binding site [chemical binding]; other site
483179000194	dimer interface [polypeptide binding]; other site
483179000195	active site
483179000196	metal binding site [ion binding]; metal-binding site
483179000197	Transcriptional regulator [Transcription]; Region: LysR; COG0583
483179000198	Helix-turn-helix domains; Region: HTH; cl00088
483179000199	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
483179000200	putative effector binding pocket; other site
483179000201	putative dimerization interface [polypeptide binding]; other site
483179000202	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
483179000203	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179000204	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
483179000205	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179000206	active site
483179000207	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
483179000208	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
483179000209	N-acetyl-D-glucosamine binding site [chemical binding]; other site
483179000210	catalytic residue [active]
483179000211	Haemolysin-III related; Region: HlyIII; cl03831
483179000212	DNA Polymerase Y-family; Region: PolY_like; cd03468
483179000213	active site
483179000214	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
483179000215	DNA binding site [nucleotide binding]
483179000216	Cell division inhibitor SulA; Region: SulA; cl01880
483179000217	Haemagglutinin; Region: HIM; pfam05662
483179000218	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
483179000219	Haemagglutinin; Region: HIM; pfam05662
483179000220	Haemagglutinin; Region: HIM; pfam05662
483179000221	Haemagglutinin; Region: HIM; pfam05662
483179000222	YadA-like C-terminal region; Region: YadA; pfam03895
483179000223	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
483179000224	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
483179000225	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
483179000226	ANP binding site [chemical binding]; other site
483179000227	Substrate Binding Site II [chemical binding]; other site
483179000228	Substrate Binding Site I [chemical binding]; other site
483179000229	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
483179000230	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179000231	FeS/SAM binding site; other site
483179000232	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
483179000233	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
483179000234	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
483179000235	aromatic arch; other site
483179000236	DCoH dimer interaction site [polypeptide binding]; other site
483179000237	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
483179000238	DCoH tetramer interaction site [polypeptide binding]; other site
483179000239	substrate binding site [chemical binding]; other site
483179000240	Low molecular weight phosphatase family; Region: LMWPc; cd00115
483179000241	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
483179000242	active site
483179000243	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
483179000244	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
483179000245	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
483179000246	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
483179000247	active site
483179000248	catalytic triad [active]
483179000249	oxyanion hole [active]
483179000250	switch loop; other site
483179000251	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
483179000252	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
483179000253	Walker A/P-loop; other site
483179000254	ATP binding site [chemical binding]; other site
483179000255	Q-loop/lid; other site
483179000256	ABC transporter signature motif; other site
483179000257	Walker B; other site
483179000258	D-loop; other site
483179000259	H-loop/switch region; other site
483179000260	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
483179000261	ybhL leader; BCAN_A0089
483179000262	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
483179000263	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
483179000264	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
483179000265	Coenzyme A binding pocket [chemical binding]; other site
483179000266	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
483179000267	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
483179000268	aconitate hydratase; Validated; Region: PRK09277
483179000269	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
483179000270	substrate binding site [chemical binding]; other site
483179000271	ligand binding site [chemical binding]; other site
483179000272	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
483179000273	substrate binding site [chemical binding]; other site
483179000274	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
483179000275	CcmA, the ATP-binding component of the bacterial CcmAB transporter.  The CCM family is involved in bacterial cytochrome c biogenesis.  Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH).  CcmE...; Region: ABC_CcmA_heme_exporter; cd03231
483179000276	Walker A/P-loop; other site
483179000277	ATP binding site [chemical binding]; other site
483179000278	Q-loop/lid; other site
483179000279	ABC transporter signature motif; other site
483179000280	Walker B; other site
483179000281	D-loop; other site
483179000282	H-loop/switch region; other site
483179000283	CcmB protein; Region: CcmB; cl01016
483179000284	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
483179000285	Heme exporter protein D (CcmD); Region: CcmD; cl11475
483179000286	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
483179000287	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
483179000288	catalytic residues [active]
483179000289	central insert; other site
483179000290	Dehydratase family; Region: ILVD_EDD; cl00340
483179000291	response regulator; Provisional; Region: PRK13435
483179000292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
483179000293	AsnC family; Region: AsnC_trans_reg; pfam01037
483179000294	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
483179000295	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
483179000296	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
483179000297	putative active site [active]
483179000298	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179000299	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
483179000300	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
483179000301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179000302	dimer interface [polypeptide binding]; other site
483179000303	conserved gate region; other site
483179000304	putative PBP binding loops; other site
483179000305	ABC-ATPase subunit interface; other site
483179000306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179000307	dimer interface [polypeptide binding]; other site
483179000308	conserved gate region; other site
483179000309	putative PBP binding loops; other site
483179000310	ABC-ATPase subunit interface; other site
483179000311	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
483179000312	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
483179000313	Walker A/P-loop; other site
483179000314	ATP binding site [chemical binding]; other site
483179000315	Q-loop/lid; other site
483179000316	ABC transporter signature motif; other site
483179000317	Walker B; other site
483179000318	D-loop; other site
483179000319	H-loop/switch region; other site
483179000320	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
483179000321	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
483179000322	Putative glucoamylase; Region: Glycoamylase; pfam10091
483179000323	Putative carbohydrate binding domain; Region: CBM_X; cl05621
483179000324	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
483179000325	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
483179000326	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
483179000327	Putative carbohydrate binding domain; Region: CBM_X; cl05621
483179000328	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
483179000329	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
483179000330	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
483179000331	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
483179000332	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
483179000333	active site
483179000334	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
483179000335	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
483179000336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179000337	S-adenosylmethionine binding site [chemical binding]; other site
483179000338	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
483179000339	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
483179000340	putative substrate binding site [chemical binding]; other site
483179000341	putative ATP binding site [chemical binding]; other site
483179000342	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
483179000343	classical (c) SDRs; Region: SDR_c; cd05233
483179000344	NAD(P) binding site [chemical binding]; other site
483179000345	active site
483179000346	Transglycosylase; Region: Transgly; cl07896
483179000347	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
483179000348	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179000349	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179000350	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179000351	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
483179000352	catalytic site [active]
483179000353	putative active site [active]
483179000354	putative substrate binding site [chemical binding]; other site
483179000355	hypothetical protein; Validated; Region: PRK09104
483179000356	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
483179000357	metal binding site [ion binding]; metal-binding site
483179000358	putative dimer interface [polypeptide binding]; other site
483179000359	DNA polymerase I; Region: pola; TIGR00593
483179000360	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
483179000361	active site
483179000362	metal binding site 1 [ion binding]; metal-binding site
483179000363	putative 5' ssDNA interaction site; other site
483179000364	metal binding site 3; metal-binding site
483179000365	metal binding site 2 [ion binding]; metal-binding site
483179000366	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
483179000367	putative DNA binding site [nucleotide binding]; other site
483179000368	putative metal binding site [ion binding]; other site
483179000369	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
483179000370	active site
483179000371	catalytic site [active]
483179000372	substrate binding site [chemical binding]; other site
483179000373	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
483179000374	active site
483179000375	DNA binding site [nucleotide binding]
483179000376	catalytic site [active]
483179000377	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
483179000378	DEAD-like helicases superfamily; Region: DEXDc; smart00487
483179000379	ATP binding site [chemical binding]; other site
483179000380	Mg++ binding site [ion binding]; other site
483179000381	motif III; other site
483179000382	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
483179000383	nucleotide binding region [chemical binding]; other site
483179000384	ATP-binding site [chemical binding]; other site
483179000385	ATP-dependent helicase HepA; Validated; Region: PRK04914
483179000386	DbpA RNA binding domain; Region: DbpA; pfam03880
483179000387	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
483179000388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179000389	Mg2+ binding site [ion binding]; other site
483179000390	G-X-G motif; other site
483179000391	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
483179000392	anchoring element; other site
483179000393	dimer interface [polypeptide binding]; other site
483179000394	ATP binding site [chemical binding]; other site
483179000395	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
483179000396	active site
483179000397	metal binding site [ion binding]; metal-binding site
483179000398	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
483179000399	Predicted esterase [General function prediction only]; Region: COG0627
483179000400	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179000401	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
483179000402	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179000403	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
483179000404	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
483179000405	substrate binding site [chemical binding]; other site
483179000406	catalytic Zn binding site [ion binding]; other site
483179000407	NAD binding site [chemical binding]; other site
483179000408	structural Zn binding site [ion binding]; other site
483179000409	dimer interface [polypeptide binding]; other site
483179000410	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
483179000411	putative metal binding site [ion binding]; other site
483179000412	putative homodimer interface [polypeptide binding]; other site
483179000413	putative homotetramer interface [polypeptide binding]; other site
483179000414	putative homodimer-homodimer interface [polypeptide binding]; other site
483179000415	putative allosteric switch controlling residues; other site
483179000416	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
483179000417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179000418	ATP binding site [chemical binding]; other site
483179000419	Mg2+ binding site [ion binding]; other site
483179000420	G-X-G motif; other site
483179000421	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179000422	hemY protein; Region: hemY_coli; TIGR00540
483179000423	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179000424	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
483179000425	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
483179000426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179000427	active site
483179000428	phosphorylation site [posttranslational modification]
483179000429	intermolecular recognition site; other site
483179000430	dimerization interface [polypeptide binding]; other site
483179000431	Helix-turn-helix domains; Region: HTH; cl00088
483179000432	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
483179000433	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179000434	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
483179000435	NifU-like domain; Region: NifU; cl00484
483179000436	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
483179000437	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
483179000438	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
483179000439	active site
483179000440	HIGH motif; other site
483179000441	dimer interface [polypeptide binding]; other site
483179000442	KMSKS motif; other site
483179000443	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
483179000444	MatE; Region: MatE; cl10513
483179000445	PII uridylyl-transferase; Provisional; Region: PRK05092
483179000446	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
483179000447	metal binding triad; other site
483179000448	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
483179000449	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
483179000450	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
483179000451	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
483179000452	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
483179000453	MutS domain I; Region: MutS_I; pfam01624
483179000454	MutS domain II; Region: MutS_II; pfam05188
483179000455	MutS family domain IV; Region: MutS_IV; pfam05190
483179000456	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
483179000457	Walker A/P-loop; other site
483179000458	ATP binding site [chemical binding]; other site
483179000459	Q-loop/lid; other site
483179000460	ABC transporter signature motif; other site
483179000461	Walker B; other site
483179000462	D-loop; other site
483179000463	H-loop/switch region; other site
483179000464	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179000465	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
483179000466	lipoprotein signal peptidase; Provisional; Region: PRK14787
483179000467	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
483179000468	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
483179000469	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
483179000470	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
483179000471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179000472	S-adenosylmethionine binding site [chemical binding]; other site
483179000473	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
483179000474	IHF dimer interface [polypeptide binding]; other site
483179000475	IHF - DNA interface [nucleotide binding]; other site
483179000476	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
483179000477	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
483179000478	tandem repeat interface [polypeptide binding]; other site
483179000479	oligomer interface [polypeptide binding]; other site
483179000480	active site residues [active]
483179000481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
483179000482	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
483179000483	OstA-like protein; Region: OstA; cl00844
483179000484	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
483179000485	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
483179000486	Walker A/P-loop; other site
483179000487	ATP binding site [chemical binding]; other site
483179000488	Q-loop/lid; other site
483179000489	ABC transporter signature motif; other site
483179000490	Walker B; other site
483179000491	D-loop; other site
483179000492	H-loop/switch region; other site
483179000493	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
483179000494	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
483179000495	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
483179000496	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
483179000497	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
483179000498	30S subunit binding site; other site
483179000499	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
483179000500	active site
483179000501	phosphorylation site [posttranslational modification]
483179000502	Protein of unknown function (DUF1150); Region: DUF1150; cl11577
483179000503	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
483179000504	putative dimer interface [polypeptide binding]; other site
483179000505	Integral membrane protein (DUF2244); Region: DUF2244; cl02302
483179000506	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
483179000507	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
483179000508	minor groove reading motif; other site
483179000509	helix-hairpin-helix signature motif; other site
483179000510	substrate binding pocket [chemical binding]; other site
483179000511	active site
483179000512	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
483179000513	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
483179000514	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168
483179000515	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
483179000516	substrate binding site [chemical binding]; other site
483179000517	ATP binding site [chemical binding]; other site
483179000518	Predicted membrane protein [Function unknown]; Region: COG2860
483179000519	UPF0126 domain; Region: UPF0126; pfam03458
483179000520	UPF0126 domain; Region: UPF0126; pfam03458
483179000521	heat shock protein GrpE; Provisional; Region: PRK14141
483179000522	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
483179000523	dimer interface [polypeptide binding]; other site
483179000524	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
483179000525	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
483179000526	ribonuclease PH; Reviewed; Region: rph; PRK00173
483179000527	Ribonuclease PH; Region: RNase_PH_bact; cd11362
483179000528	hexamer interface [polypeptide binding]; other site
483179000529	active site
483179000530	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179000531	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
483179000532	putative metal binding site [ion binding]; other site
483179000533	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
483179000534	active site
483179000535	dimerization interface [polypeptide binding]; other site
483179000536	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
483179000537	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179000538	FeS/SAM binding site; other site
483179000539	HemN C-terminal domain; Region: HemN_C; pfam06969
483179000540	Predicted methyltransferases [General function prediction only]; Region: COG0313
483179000541	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
483179000542	Restriction endonuclease; Region: Mrr_cat; cl00516
483179000543	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
483179000544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179000545	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
483179000546	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
483179000547	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
483179000548	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
483179000549	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
483179000550	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
483179000551	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
483179000552	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
483179000553	Active Sites [active]
483179000554	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
483179000555	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
483179000556	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
483179000557	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
483179000558	active site
483179000559	DNA binding site [nucleotide binding]
483179000560	BA14K-like protein; Region: BA14K; pfam07886
483179000561	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
483179000562	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
483179000563	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
483179000564	substrate binding pocket [chemical binding]; other site
483179000565	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
483179000566	B12 binding site [chemical binding]; other site
483179000567	cobalt ligand [ion binding]; other site
483179000568	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
483179000569	Dehydratase family; Region: ILVD_EDD; cl00340
483179000570	Autoinducer binding domain; Region: Autoind_bind; pfam03472
483179000571	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
483179000572	DNA binding residues [nucleotide binding]
483179000573	aminotransferase; Provisional; Region: PRK06105
483179000574	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
483179000575	inhibitor-cofactor binding pocket; inhibition site
483179000576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179000577	catalytic residue [active]
483179000578	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
483179000579	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
483179000580	Active Sites [active]
483179000581	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
483179000582	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
483179000583	CysD dimerization site [polypeptide binding]; other site
483179000584	G1 box; other site
483179000585	putative GEF interaction site [polypeptide binding]; other site
483179000586	GTP/Mg2+ binding site [chemical binding]; other site
483179000587	Switch I region; other site
483179000588	G2 box; other site
483179000589	G3 box; other site
483179000590	Switch II region; other site
483179000591	G4 box; other site
483179000592	G5 box; other site
483179000593	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
483179000594	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
483179000595	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
483179000596	ligand-binding site [chemical binding]; other site
483179000597	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
483179000598	active site
483179000599	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
483179000600	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
483179000601	ligand binding site [chemical binding]; other site
483179000602	flexible hinge region; other site
483179000603	Helix-turn-helix domains; Region: HTH; cl00088
483179000604	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
483179000605	Helix-turn-helix domains; Region: HTH; cl00088
483179000606	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
483179000607	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
483179000608	GAF domain; Region: GAF; cl15785
483179000609	Helix-turn-helix domains; Region: HTH; cl00088
483179000610	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
483179000611	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179000612	NAD(P) binding site [chemical binding]; other site
483179000613	catalytic residues [active]
483179000614	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
483179000615	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
483179000616	NAD binding site [chemical binding]; other site
483179000617	substrate binding site [chemical binding]; other site
483179000618	catalytic Zn binding site [ion binding]; other site
483179000619	tetramer interface [polypeptide binding]; other site
483179000620	structural Zn binding site [ion binding]; other site
483179000621	Protein of unknown function (DUF779); Region: DUF779; cl01432
483179000622	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
483179000623	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179000624	NAD(P) binding site [chemical binding]; other site
483179000625	catalytic residues [active]
483179000626	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
483179000627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179000628	dimer interface [polypeptide binding]; other site
483179000629	conserved gate region; other site
483179000630	putative PBP binding loops; other site
483179000631	ABC-ATPase subunit interface; other site
483179000632	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
483179000633	NMT1/THI5 like; Region: NMT1; pfam09084
483179000634	NMT1-like family; Region: NMT1_2; cl15260
483179000635	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
483179000636	active site
483179000637	thiamine phosphate binding site [chemical binding]; other site
483179000638	pyrophosphate binding site [ion binding]; other site
483179000639	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
483179000640	ThiS interaction site; other site
483179000641	putative active site [active]
483179000642	tetramer interface [polypeptide binding]; other site
483179000643	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
483179000644	thiS-thiF/thiG interaction site; other site
483179000645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179000646	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
483179000647	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
483179000648	dimer interface [polypeptide binding]; other site
483179000649	substrate binding site [chemical binding]; other site
483179000650	ATP binding site [chemical binding]; other site
483179000651	PAS domain S-box; Region: sensory_box; TIGR00229
483179000652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
483179000653	PAS domain S-box; Region: sensory_box; TIGR00229
483179000654	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
483179000655	putative active site [active]
483179000656	heme pocket [chemical binding]; other site
483179000657	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179000658	metal binding site [ion binding]; metal-binding site
483179000659	active site
483179000660	I-site; other site
483179000661	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
483179000662	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
483179000663	metal-binding site [ion binding]
483179000664	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
483179000665	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
483179000666	metal-binding site [ion binding]
483179000667	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
483179000668	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179000669	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
483179000670	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
483179000671	DNA binding residues [nucleotide binding]
483179000672	dimer interface [polypeptide binding]; other site
483179000673	copper binding site [ion binding]; other site
483179000674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179000675	dimer interface [polypeptide binding]; other site
483179000676	conserved gate region; other site
483179000677	putative PBP binding loops; other site
483179000678	ABC-ATPase subunit interface; other site
483179000679	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
483179000680	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
483179000681	Walker A/P-loop; other site
483179000682	ATP binding site [chemical binding]; other site
483179000683	Q-loop/lid; other site
483179000684	ABC transporter signature motif; other site
483179000685	Walker B; other site
483179000686	D-loop; other site
483179000687	H-loop/switch region; other site
483179000688	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
483179000689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
483179000690	NMT1-like family; Region: NMT1_2; cl15260
483179000691	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
483179000692	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
483179000693	heme-binding site [chemical binding]; other site
483179000694	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
483179000695	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
483179000696	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
483179000697	NAD(P) binding site [chemical binding]; other site
483179000698	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
483179000699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179000700	Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767
483179000701	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
483179000702	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
483179000703	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
483179000704	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
483179000705	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
483179000706	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
483179000707	Transcriptional regulator [Transcription]; Region: IclR; COG1414
483179000708	Helix-turn-helix domains; Region: HTH; cl00088
483179000709	Bacterial transcriptional regulator; Region: IclR; pfam01614
483179000710	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
483179000711	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179000712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179000713	dimer interface [polypeptide binding]; other site
483179000714	conserved gate region; other site
483179000715	putative PBP binding loops; other site
483179000716	ABC-ATPase subunit interface; other site
483179000717	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
483179000718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179000719	dimer interface [polypeptide binding]; other site
483179000720	conserved gate region; other site
483179000721	putative PBP binding loops; other site
483179000722	ABC-ATPase subunit interface; other site
483179000723	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
483179000724	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
483179000725	Walker A/P-loop; other site
483179000726	ATP binding site [chemical binding]; other site
483179000727	Q-loop/lid; other site
483179000728	ABC transporter signature motif; other site
483179000729	Walker B; other site
483179000730	D-loop; other site
483179000731	H-loop/switch region; other site
483179000732	TOBE domain; Region: TOBE_2; cl01440
483179000733	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
483179000734	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
483179000735	active site pocket [active]
483179000736	Domain of unknown function (DUF718); Region: DUF718; cl01281
483179000737	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179000738	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179000739	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
483179000740	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
483179000741	NAD binding site [chemical binding]; other site
483179000742	homotetramer interface [polypeptide binding]; other site
483179000743	homodimer interface [polypeptide binding]; other site
483179000744	active site
483179000745	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
483179000746	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
483179000747	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
483179000748	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
483179000749	putative active site pocket [active]
483179000750	metal binding site [ion binding]; metal-binding site
483179000751	Domain of unknown function (DUF329); Region: DUF329; cl01144
483179000752	Maf-like protein; Region: Maf; pfam02545
483179000753	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
483179000754	active site
483179000755	dimer interface [polypeptide binding]; other site
483179000756	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
483179000757	rRNA binding site [nucleotide binding]; other site
483179000758	predicted 30S ribosome binding site; other site
483179000759	Low molecular weight phosphatase family; Region: LMWPc; cd00115
483179000760	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
483179000761	active site
483179000762	Uncharacterized protein family (UPF0262); Region: UPF0262; cl11489
483179000763	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
483179000764	histidinol dehydrogenase; Region: hisD; TIGR00069
483179000765	NAD binding site [chemical binding]; other site
483179000766	dimerization interface [polypeptide binding]; other site
483179000767	product binding site; other site
483179000768	substrate binding site [chemical binding]; other site
483179000769	zinc binding site [ion binding]; other site
483179000770	catalytic residues [active]
483179000771	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
483179000772	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
483179000773	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
483179000774	hinge; other site
483179000775	active site
483179000776	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
483179000777	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
483179000778	active site
483179000779	DNA binding site [nucleotide binding]
483179000780	Int/Topo IB signature motif; other site
483179000781	BRO family, N-terminal domain; Region: Bro-N; cl10591
483179000782	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
483179000783	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
483179000784	catalytic residues [active]
483179000785	catalytic nucleophile [active]
483179000786	Presynaptic Site I dimer interface [polypeptide binding]; other site
483179000787	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
483179000788	Synaptic Flat tetramer interface [polypeptide binding]; other site
483179000789	Synaptic Site I dimer interface [polypeptide binding]; other site
483179000790	DNA binding site [nucleotide binding]
483179000791	BRO family, N-terminal domain; Region: Bro-N; cl10591
483179000792	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
483179000793	UreD urease accessory protein; Region: UreD; cl00530
483179000794	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
483179000795	alpha-gamma subunit interface [polypeptide binding]; other site
483179000796	beta-gamma subunit interface [polypeptide binding]; other site
483179000797	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
483179000798	gamma-beta subunit interface [polypeptide binding]; other site
483179000799	alpha-beta subunit interface [polypeptide binding]; other site
483179000800	urease subunit alpha; Reviewed; Region: ureC; PRK13207
483179000801	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
483179000802	subunit interactions [polypeptide binding]; other site
483179000803	active site
483179000804	flap region; other site
483179000805	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
483179000806	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
483179000807	dimer interface [polypeptide binding]; other site
483179000808	catalytic residues [active]
483179000809	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
483179000810	UreF; Region: UreF; pfam01730
483179000811	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179000812	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
483179000813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179000814	ATP binding site [chemical binding]; other site
483179000815	Mg2+ binding site [ion binding]; other site
483179000816	G-X-G motif; other site
483179000817	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
483179000818	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179000819	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179000820	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
483179000821	phenylhydantoinase; Validated; Region: PRK08323
483179000822	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
483179000823	tetramer interface [polypeptide binding]; other site
483179000824	active site
483179000825	allantoate amidohydrolase; Reviewed; Region: PRK12893
483179000826	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
483179000827	active site
483179000828	metal binding site [ion binding]; metal-binding site
483179000829	dimer interface [polypeptide binding]; other site
483179000830	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
483179000831	Helix-turn-helix domains; Region: HTH; cl00088
483179000832	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
483179000833	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
483179000834	nudix motif; other site
483179000835	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
483179000836	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
483179000837	homodimer interface [polypeptide binding]; other site
483179000838	active site
483179000839	FMN binding site [chemical binding]; other site
483179000840	substrate binding site [chemical binding]; other site
483179000841	4Fe-4S binding domain; Region: Fer4; cl02805
483179000842	4Fe-4S binding domain; Region: Fer4; cl02805
483179000843	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
483179000844	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179000845	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179000846	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
483179000847	putative hydrophobic ligand binding site [chemical binding]; other site
483179000848	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
483179000849	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
483179000850	active site
483179000851	dimer interface [polypeptide binding]; other site
483179000852	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
483179000853	dimer interface [polypeptide binding]; other site
483179000854	active site
483179000855	Predicted deacylase [General function prediction only]; Region: COG3608
483179000856	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
483179000857	active site
483179000858	Zn binding site [ion binding]; other site
483179000859	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
483179000860	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179000861	motif II; other site
483179000862	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179000863	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
483179000864	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
483179000865	AMP-binding enzyme; Region: AMP-binding; cl15778
483179000866	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179000867	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
483179000868	Helix-turn-helix domains; Region: HTH; cl00088
483179000869	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
483179000870	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
483179000871	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179000872	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179000873	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
483179000874	Protein export membrane protein; Region: SecD_SecF; cl14618
483179000875	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
483179000876	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
483179000877	substrate binding pocket [chemical binding]; other site
483179000878	membrane-bound complex binding site; other site
483179000879	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
483179000880	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
483179000881	DXD motif; other site
483179000882	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
483179000883	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
483179000884	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179000885	dimer interface [polypeptide binding]; other site
483179000886	phosphorylation site [posttranslational modification]
483179000887	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179000888	ATP binding site [chemical binding]; other site
483179000889	Mg2+ binding site [ion binding]; other site
483179000890	G-X-G motif; other site
483179000891	GcrA cell cycle regulator; Region: GcrA; cl11564
483179000892	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
483179000893	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
483179000894	inhibitor-cofactor binding pocket; inhibition site
483179000895	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179000896	catalytic residue [active]
483179000897	ornithine carbamoyltransferase; Provisional; Region: PRK00779
483179000898	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
483179000899	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179000900	Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281
483179000901	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
483179000902	dimerization interface [polypeptide binding]; other site
483179000903	domain crossover interface; other site
483179000904	redox-dependent activation switch; other site
483179000905	Protein of unknown function (DUF525); Region: DUF525; cl01119
483179000906	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
483179000907	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
483179000908	homodimer interface [polypeptide binding]; other site
483179000909	substrate-cofactor binding pocket; other site
483179000910	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179000911	catalytic residue [active]
483179000912	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
483179000913	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
483179000914	trimer interface [polypeptide binding]; other site
483179000915	active site
483179000916	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
483179000917	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
483179000918	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
483179000919	conserved cys residue [active]
483179000920	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
483179000921	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
483179000922	MatE; Region: MatE; cl10513
483179000923	MatE; Region: MatE; cl10513
483179000924	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
483179000925	quinone interaction residues [chemical binding]; other site
483179000926	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
483179000927	active site
483179000928	catalytic residues [active]
483179000929	FMN binding site [chemical binding]; other site
483179000930	substrate binding site [chemical binding]; other site
483179000931	Protein of unknown function (DUF952); Region: DUF952; cl01393
483179000932	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
483179000933	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179000934	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
483179000935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179000936	active site
483179000937	phosphorylation site [posttranslational modification]
483179000938	intermolecular recognition site; other site
483179000939	dimerization interface [polypeptide binding]; other site
483179000940	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
483179000941	DNA binding residues [nucleotide binding]
483179000942	dimerization interface [polypeptide binding]; other site
483179000943	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
483179000944	Na binding site [ion binding]; other site
483179000945	PAS fold; Region: PAS_7; pfam12860
483179000946	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179000947	dimer interface [polypeptide binding]; other site
483179000948	phosphorylation site [posttranslational modification]
483179000949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179000950	ATP binding site [chemical binding]; other site
483179000951	Mg2+ binding site [ion binding]; other site
483179000952	G-X-G motif; other site
483179000953	Response regulator receiver domain; Region: Response_reg; pfam00072
483179000954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179000955	active site
483179000956	phosphorylation site [posttranslational modification]
483179000957	intermolecular recognition site; other site
483179000958	dimerization interface [polypeptide binding]; other site
483179000959	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
483179000960	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
483179000961	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
483179000962	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
483179000963	substrate-cofactor binding pocket; other site
483179000964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179000965	catalytic residue [active]
483179000966	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
483179000967	putative active site [active]
483179000968	putative metal binding site [ion binding]; other site
483179000969	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
483179000970	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
483179000971	Transcriptional regulator [Transcription]; Region: LysR; COG0583
483179000972	Helix-turn-helix domains; Region: HTH; cl00088
483179000973	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
483179000974	putative dimerization interface [polypeptide binding]; other site
483179000975	LrgA family; Region: LrgA; cl00608
483179000976	LrgB-like family; Region: LrgB; cl00596
483179000977	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
483179000978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
483179000979	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
483179000980	pantoate--beta-alanine ligase; Region: panC; TIGR00018
483179000981	Pantoate-beta-alanine ligase; Region: PanC; cd00560
483179000982	active site
483179000983	ATP-binding site [chemical binding]; other site
483179000984	pantoate-binding site; other site
483179000985	HXXH motif; other site
483179000986	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
483179000987	active site
483179000988	oligomerization interface [polypeptide binding]; other site
483179000989	metal binding site [ion binding]; metal-binding site
483179000990	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
483179000991	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
483179000992	FAD binding pocket [chemical binding]; other site
483179000993	FAD binding motif [chemical binding]; other site
483179000994	phosphate binding motif [ion binding]; other site
483179000995	beta-alpha-beta structure motif; other site
483179000996	NAD binding pocket [chemical binding]; other site
483179000997	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
483179000998	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
483179000999	dimer interface [polypeptide binding]; other site
483179001000	active site
483179001001	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
483179001002	catalytic residues [active]
483179001003	substrate binding site [chemical binding]; other site
483179001004	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
483179001005	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179001006	NAD(P) binding pocket [chemical binding]; other site
483179001007	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
483179001008	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
483179001009	multidrug efflux protein; Reviewed; Region: PRK01766
483179001010	MatE; Region: MatE; cl10513
483179001011	MatE; Region: MatE; cl10513
483179001012	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
483179001013	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
483179001014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179001015	active site
483179001016	phosphorylation site [posttranslational modification]
483179001017	intermolecular recognition site; other site
483179001018	dimerization interface [polypeptide binding]; other site
483179001019	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
483179001020	DNA binding residues [nucleotide binding]
483179001021	dimerization interface [polypeptide binding]; other site
483179001022	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
483179001023	DctM-like transporters; Region: DctM; pfam06808
483179001024	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
483179001025	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
483179001026	hypothetical protein; Provisional; Region: PRK11171
483179001027	Cupin domain; Region: Cupin_2; cl09118
483179001028	Cupin domain; Region: Cupin_2; cl09118
483179001029	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
483179001030	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
483179001031	active site
483179001032	catalytic site [active]
483179001033	tetramer interface [polypeptide binding]; other site
483179001034	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
483179001035	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000
483179001036	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
483179001037	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
483179001038	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
483179001039	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
483179001040	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
483179001041	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
483179001042	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
483179001043	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
483179001044	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
483179001045	XdhC Rossmann domain; Region: XdhC_C; pfam13478
483179001046	LysR family transcriptional regulator; Provisional; Region: PRK14997
483179001047	Helix-turn-helix domains; Region: HTH; cl00088
483179001048	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
483179001049	putative effector binding pocket; other site
483179001050	dimerization interface [polypeptide binding]; other site
483179001051	Predicted membrane protein [Function unknown]; Region: COG3748
483179001052	Protein of unknown function (DUF989); Region: DUF989; pfam06181
483179001053	Cytochrome c; Region: Cytochrom_C; cl11414
483179001054	guanine deaminase; Provisional; Region: PRK09228
483179001055	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
483179001056	active site
483179001057	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
483179001058	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
483179001059	MOFRL family; Region: MOFRL; pfam05161
483179001060	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
483179001061	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
483179001062	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
483179001063	metal-binding site [ion binding]
483179001064	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
483179001065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179001066	motif II; other site
483179001067	FixH; Region: FixH; cl01254
483179001068	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
483179001069	4Fe-4S binding domain; Region: Fer4_5; pfam12801
483179001070	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
483179001071	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
483179001072	Cytochrome c; Region: Cytochrom_C; cl11414
483179001073	Cytochrome c; Region: Cytochrom_C; cl11414
483179001074	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
483179001075	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
483179001076	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
483179001077	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
483179001078	Low-spin heme binding site [chemical binding]; other site
483179001079	Putative water exit pathway; other site
483179001080	Binuclear center (active site) [active]
483179001081	Putative proton exit pathway; other site
483179001082	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
483179001083	metal binding site 2 [ion binding]; metal-binding site
483179001084	putative DNA binding helix; other site
483179001085	metal binding site 1 [ion binding]; metal-binding site
483179001086	dimer interface [polypeptide binding]; other site
483179001087	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
483179001088	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
483179001089	catalytic residues [active]
483179001090	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179001091	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
483179001092	NAD(P) binding site [chemical binding]; other site
483179001093	catalytic residues [active]
483179001094	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
483179001095	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
483179001096	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179001097	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
483179001098	DNA binding site [nucleotide binding]
483179001099	active site
483179001100	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
483179001101	ArsC family; Region: ArsC; pfam03960
483179001102	putative catalytic residues [active]
483179001103	Predicted membrane protein [Function unknown]; Region: COG4129
483179001104	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
483179001105	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179001106	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
483179001107	NodB motif; other site
483179001108	putative active site [active]
483179001109	putative catalytic site [active]
483179001110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
483179001111	GTP-binding protein Der; Reviewed; Region: PRK00093
483179001112	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
483179001113	G1 box; other site
483179001114	GTP/Mg2+ binding site [chemical binding]; other site
483179001115	Switch I region; other site
483179001116	G2 box; other site
483179001117	Switch II region; other site
483179001118	G3 box; other site
483179001119	G4 box; other site
483179001120	G5 box; other site
483179001121	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
483179001122	G1 box; other site
483179001123	GTP/Mg2+ binding site [chemical binding]; other site
483179001124	Switch I region; other site
483179001125	G2 box; other site
483179001126	G3 box; other site
483179001127	Switch II region; other site
483179001128	G4 box; other site
483179001129	G5 box; other site
483179001130	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
483179001131	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
483179001132	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
483179001133	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
483179001134	ATP synthase A chain; Region: ATP-synt_A; cl00413
483179001135	ATP synthase subunit C; Region: ATP-synt_C; cl00466
483179001136	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
483179001137	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
483179001138	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
483179001139	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
483179001140	RNA/DNA hybrid binding site [nucleotide binding]; other site
483179001141	active site
483179001142	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
483179001143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179001144	FeS/SAM binding site; other site
483179001145	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
483179001146	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
483179001147	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
483179001148	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
483179001149	tandem repeat interface [polypeptide binding]; other site
483179001150	oligomer interface [polypeptide binding]; other site
483179001151	active site residues [active]
483179001152	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
483179001153	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
483179001154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179001155	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
483179001156	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
483179001157	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
483179001158	substrate binding pocket [chemical binding]; other site
483179001159	chain length determination region; other site
483179001160	substrate-Mg2+ binding site; other site
483179001161	catalytic residues [active]
483179001162	aspartate-rich region 1; other site
483179001163	active site lid residues [active]
483179001164	aspartate-rich region 2; other site
483179001165	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
483179001166	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
483179001167	binding surface
483179001168	TPR motif; other site
483179001169	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
483179001170	binding surface
483179001171	TPR motif; other site
483179001172	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
483179001173	dimer interface [polypeptide binding]; other site
483179001174	motif 1; other site
483179001175	active site
483179001176	motif 2; other site
483179001177	motif 3; other site
483179001178	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
483179001179	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
483179001180	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
483179001181	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
483179001182	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
483179001183	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
483179001184	FAD binding domain; Region: FAD_binding_4; pfam01565
483179001185	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
483179001186	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
483179001187	enoyl-CoA hydratase; Provisional; Region: PRK06688
483179001188	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
483179001189	substrate binding site [chemical binding]; other site
483179001190	oxyanion hole (OAH) forming residues; other site
483179001191	trimer interface [polypeptide binding]; other site
483179001192	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
483179001193	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
483179001194	active site
483179001195	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
483179001196	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179001197	metal binding site [ion binding]; metal-binding site
483179001198	active site
483179001199	I-site; other site
483179001200	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
483179001201	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
483179001202	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179001203	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
483179001204	UbiA prenyltransferase family; Region: UbiA; cl00337
483179001205	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
483179001206	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
483179001207	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
483179001208	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
483179001209	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
483179001210	HSP70 interaction site [polypeptide binding]; other site
483179001211	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
483179001212	dimer interface [polypeptide binding]; other site
483179001213	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
483179001214	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
483179001215	NAD binding site [chemical binding]; other site
483179001216	homotetramer interface [polypeptide binding]; other site
483179001217	homodimer interface [polypeptide binding]; other site
483179001218	substrate binding site [chemical binding]; other site
483179001219	active site
483179001220	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
483179001221	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
483179001222	putative acyl-acceptor binding pocket; other site
483179001223	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
483179001224	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
483179001225	Tetramer interface [polypeptide binding]; other site
483179001226	active site
483179001227	FMN-binding site [chemical binding]; other site
483179001228	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
483179001229	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
483179001230	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
483179001231	dimerization interface [polypeptide binding]; other site
483179001232	active site
483179001233	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
483179001234	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
483179001235	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
483179001236	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
483179001237	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
483179001238	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
483179001239	Pirin-related protein [General function prediction only]; Region: COG1741
483179001240	Cupin domain; Region: Cupin_2; cl09118
483179001241	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
483179001242	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
483179001243	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
483179001244	TPP-binding site; other site
483179001245	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
483179001246	PYR/PP interface [polypeptide binding]; other site
483179001247	dimer interface [polypeptide binding]; other site
483179001248	TPP binding site [chemical binding]; other site
483179001249	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
483179001250	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
483179001251	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
483179001252	RNA binding surface [nucleotide binding]; other site
483179001253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179001254	S-adenosylmethionine binding site [chemical binding]; other site
483179001255	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
483179001256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179001257	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
483179001258	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
483179001259	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
483179001260	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
483179001261	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179001262	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
483179001263	ATM1 is an ABC transporter that is expressed in the mitochondria.  Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253
483179001264	Walker A/P-loop; other site
483179001265	ATP binding site [chemical binding]; other site
483179001266	Q-loop/lid; other site
483179001267	ABC transporter signature motif; other site
483179001268	Walker B; other site
483179001269	D-loop; other site
483179001270	H-loop/switch region; other site
483179001271	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
483179001272	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
483179001273	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
483179001274	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
483179001275	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
483179001276	classical (c) SDRs; Region: SDR_c; cd05233
483179001277	NAD(P) binding site [chemical binding]; other site
483179001278	active site
483179001279	amidophosphoribosyltransferase; Provisional; Region: PRK09123
483179001280	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
483179001281	active site
483179001282	tetramer interface [polypeptide binding]; other site
483179001283	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
483179001284	active site
483179001285	Colicin V production protein; Region: Colicin_V; cl00567
483179001286	DNA repair protein RadA; Provisional; Region: PRK11823
483179001287	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
483179001288	Walker A motif/ATP binding site; other site
483179001289	ATP binding site [chemical binding]; other site
483179001290	Walker B motif; other site
483179001291	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
483179001292	replicative DNA helicase; Provisional; Region: PRK09165
483179001293	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
483179001294	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
483179001295	Walker A motif; other site
483179001296	ATP binding site [chemical binding]; other site
483179001297	Walker B motif; other site
483179001298	DNA binding loops [nucleotide binding]
483179001299	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
483179001300	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
483179001301	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
483179001302	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
483179001303	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
483179001304	Acyl transferase domain; Region: Acyl_transf_1; cl08282
483179001305	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
483179001306	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
483179001307	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
483179001308	NAD(P) binding site [chemical binding]; other site
483179001309	homotetramer interface [polypeptide binding]; other site
483179001310	homodimer interface [polypeptide binding]; other site
483179001311	active site
483179001312	Phosphopantetheine attachment site; Region: PP-binding; cl09936
483179001313	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
483179001314	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
483179001315	dimer interface [polypeptide binding]; other site
483179001316	active site
483179001317	YceG-like family; Region: YceG; pfam02618
483179001318	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
483179001319	dimerization interface [polypeptide binding]; other site
483179001320	hypothetical protein; Provisional; Region: PRK11820
483179001321	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
483179001322	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
483179001323	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
483179001324	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
483179001325	catalytic site [active]
483179001326	G-X2-G-X-G-K; other site
483179001327	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
483179001328	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
483179001329	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
483179001330	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
483179001331	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
483179001332	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179001333	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
483179001334	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
483179001335	Subunit I/III interface [polypeptide binding]; other site
483179001336	D-pathway; other site
483179001337	Subunit I/VIIc interface [polypeptide binding]; other site
483179001338	Subunit I/IV interface [polypeptide binding]; other site
483179001339	Subunit I/II interface [polypeptide binding]; other site
483179001340	Low-spin heme (heme a) binding site [chemical binding]; other site
483179001341	Subunit I/VIIa interface [polypeptide binding]; other site
483179001342	Subunit I/VIa interface [polypeptide binding]; other site
483179001343	Dimer interface; other site
483179001344	Putative water exit pathway; other site
483179001345	Binuclear center (heme a3/CuB) [ion binding]; other site
483179001346	K-pathway; other site
483179001347	Subunit I/Vb interface [polypeptide binding]; other site
483179001348	Putative proton exit pathway; other site
483179001349	Subunit I/VIb interface; other site
483179001350	Subunit I/VIc interface [polypeptide binding]; other site
483179001351	Electron transfer pathway; other site
483179001352	Subunit I/VIIIb interface [polypeptide binding]; other site
483179001353	Subunit I/VIIb interface [polypeptide binding]; other site
483179001354	UbiA prenyltransferase family; Region: UbiA; cl00337
483179001355	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
483179001356	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
483179001357	Subunit III/VIIa interface [polypeptide binding]; other site
483179001358	Phospholipid binding site [chemical binding]; other site
483179001359	Subunit I/III interface [polypeptide binding]; other site
483179001360	Subunit III/VIb interface [polypeptide binding]; other site
483179001361	Subunit III/VIa interface; other site
483179001362	Subunit III/Vb interface [polypeptide binding]; other site
483179001363	Protein of unknown function (DUF983); Region: DUF983; cl02211
483179001364	LytB protein; Region: LYTB; cl00507
483179001365	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
483179001366	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
483179001367	Phosphotransferase enzyme family; Region: APH; pfam01636
483179001368	putative active site [active]
483179001369	putative substrate binding site [chemical binding]; other site
483179001370	ATP binding site [chemical binding]; other site
483179001371	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
483179001372	RNA/DNA hybrid binding site [nucleotide binding]; other site
483179001373	active site
483179001374	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
483179001375	catalytic triad [active]
483179001376	dimer interface [polypeptide binding]; other site
483179001377	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
483179001378	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
483179001379	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
483179001380	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
483179001381	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
483179001382	PAS fold; Region: PAS_3; pfam08447
483179001383	putative active site [active]
483179001384	heme pocket [chemical binding]; other site
483179001385	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179001386	metal binding site [ion binding]; metal-binding site
483179001387	active site
483179001388	I-site; other site
483179001389	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
483179001390	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
483179001391	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179001392	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
483179001393	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
483179001394	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
483179001395	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
483179001396	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
483179001397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179001398	catalytic residue [active]
483179001399	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
483179001400	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
483179001401	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
483179001402	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
483179001403	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179001404	active site
483179001405	motif I; other site
483179001406	motif II; other site
483179001407	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
483179001408	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
483179001409	Cl- selectivity filter; other site
483179001410	Cl- binding residues [ion binding]; other site
483179001411	pore gating glutamate residue; other site
483179001412	dimer interface [polypeptide binding]; other site
483179001413	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
483179001414	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
483179001415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179001416	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
483179001417	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179001418	motif II; other site
483179001419	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
483179001420	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
483179001421	minor groove reading motif; other site
483179001422	helix-hairpin-helix signature motif; other site
483179001423	substrate binding pocket [chemical binding]; other site
483179001424	active site
483179001425	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
483179001426	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
483179001427	DNA binding and oxoG recognition site [nucleotide binding]
483179001428	Protein of unknown function (DUF721); Region: DUF721; cl02324
483179001429	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
483179001430	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
483179001431	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
483179001432	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
483179001433	Walker A/P-loop; other site
483179001434	ATP binding site [chemical binding]; other site
483179001435	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
483179001436	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
483179001437	ABC transporter signature motif; other site
483179001438	Walker B; other site
483179001439	D-loop; other site
483179001440	H-loop/switch region; other site
483179001441	Cation efflux family; Region: Cation_efflux; cl00316
483179001442	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179001443	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
483179001444	pyruvate phosphate dikinase; Provisional; Region: PRK09279
483179001445	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
483179001446	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
483179001447	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
483179001448	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
483179001449	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
483179001450	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
483179001451	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
483179001452	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
483179001453	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
483179001454	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
483179001455	active site
483179001456	homotetramer interface [polypeptide binding]; other site
483179001457	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
483179001458	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
483179001459	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
483179001460	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
483179001461	NAD(P) binding site [chemical binding]; other site
483179001462	homodimer interface [polypeptide binding]; other site
483179001463	substrate binding site [chemical binding]; other site
483179001464	active site
483179001465	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001466	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
483179001467	Helix-turn-helix domains; Region: HTH; cl00088
483179001468	Helix-turn-helix domains; Region: HTH; cl00088
483179001469	Integrase core domain; Region: rve_3; cl15866
483179001470	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001471	HTH-like domain; Region: HTH_21; pfam13276
483179001472	Integrase core domain; Region: rve; cl01316
483179001473	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
483179001474	active site
483179001475	substrate binding site [chemical binding]; other site
483179001476	cosubstrate binding site; other site
483179001477	catalytic site [active]
483179001478	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
483179001479	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
483179001480	Walker A/P-loop; other site
483179001481	ATP binding site [chemical binding]; other site
483179001482	Q-loop/lid; other site
483179001483	ABC transporter signature motif; other site
483179001484	Walker B; other site
483179001485	D-loop; other site
483179001486	H-loop/switch region; other site
483179001487	ABC-2 type transporter; Region: ABC2_membrane; cl11417
483179001488	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
483179001489	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
483179001490	inhibitor-cofactor binding pocket; inhibition site
483179001491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179001492	catalytic residue [active]
483179001493	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
483179001494	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
483179001495	NADP-binding site; other site
483179001496	homotetramer interface [polypeptide binding]; other site
483179001497	substrate binding site [chemical binding]; other site
483179001498	homodimer interface [polypeptide binding]; other site
483179001499	active site
483179001500	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001501	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001502	Integrase core domain; Region: rve; cl01316
483179001503	DDE domain; Region: DDE_Tnp_IS240; pfam13610
483179001504	Integrase core domain; Region: rve_3; cl15866
483179001505	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001506	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001507	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001508	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
483179001509	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
483179001510	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001511	Integrase core domain; Region: rve; cl01316
483179001512	Integrase core domain; Region: rve; cl01316
483179001513	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001514	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179001515	Integrase core domain; Region: rve_3; cl15866
483179001516	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
483179001517	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
483179001518	active site
483179001519	substrate binding site [chemical binding]; other site
483179001520	metal binding site [ion binding]; metal-binding site
483179001521	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
483179001522	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
483179001523	Substrate binding site; other site
483179001524	Cupin domain; Region: Cupin_2; cl09118
483179001525	N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942
483179001526	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
483179001527	dimerization interface [polypeptide binding]; other site
483179001528	putative active cleft [active]
483179001529	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
483179001530	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
483179001531	putative ADP-binding pocket [chemical binding]; other site
483179001532	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
483179001533	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
483179001534	Walker A/P-loop; other site
483179001535	ATP binding site [chemical binding]; other site
483179001536	Q-loop/lid; other site
483179001537	ABC transporter signature motif; other site
483179001538	Walker B; other site
483179001539	D-loop; other site
483179001540	H-loop/switch region; other site
483179001541	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
483179001542	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179001543	TM-ABC transporter signature motif; other site
483179001544	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
483179001545	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
483179001546	putative ligand binding site [chemical binding]; other site
483179001547	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
483179001548	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
483179001549	DNA interaction; other site
483179001550	Metal-binding active site; metal-binding site
483179001551	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
483179001552	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179001553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179001554	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
483179001555	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
483179001556	D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
483179001557	N- and C-terminal domain interface [polypeptide binding]; other site
483179001558	D-xylulose kinase; Region: XylB; TIGR01312
483179001559	active site
483179001560	catalytic site [active]
483179001561	metal binding site [ion binding]; metal-binding site
483179001562	xylulose binding site [chemical binding]; other site
483179001563	putative ATP binding site [chemical binding]; other site
483179001564	homodimer interface [polypeptide binding]; other site
483179001565	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
483179001566	DNA binding site [nucleotide binding]
483179001567	domain linker motif; other site
483179001568	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
483179001569	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
483179001570	putative ligand binding site [chemical binding]; other site
483179001571	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
483179001572	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179001573	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179001574	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
483179001575	NAD(P) binding site [chemical binding]; other site
483179001576	catalytic residues [active]
483179001577	choline dehydrogenase; Validated; Region: PRK02106
483179001578	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
483179001579	transcriptional regulator BetI; Validated; Region: PRK00767
483179001580	Helix-turn-helix domains; Region: HTH; cl00088
483179001581	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
483179001582	L-asparaginase II; Region: Asparaginase_II; cl01842
483179001583	transcription elongation factor regulatory protein; Validated; Region: PRK06342
483179001584	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
483179001585	Fic/DOC family; Region: Fic; cl00960
483179001586	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
483179001587	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
483179001588	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
483179001589	Transcriptional regulators [Transcription]; Region: FadR; COG2186
483179001590	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179001591	DNA-binding site [nucleotide binding]; DNA binding site
483179001592	FCD domain; Region: FCD; cl11656
483179001593	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
483179001594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179001595	putative substrate translocation pore; other site
483179001596	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
483179001597	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179001598	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179001599	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
483179001600	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179001601	motif II; other site
483179001602	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
483179001603	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
483179001604	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
483179001605	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
483179001606	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179001607	Predicted transcriptional regulator [Transcription]; Region: COG4957
483179001608	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
483179001609	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
483179001610	DnaA box-binding interface [nucleotide binding]; other site
483179001611	Amidase; Region: Amidase; cl11426
483179001612	Fe-S metabolism associated domain; Region: SufE; cl00951
483179001613	Flavin Reductases; Region: FlaRed; cl00801
483179001614	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
483179001615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179001616	dimer interface [polypeptide binding]; other site
483179001617	phosphorylation site [posttranslational modification]
483179001618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179001619	ATP binding site [chemical binding]; other site
483179001620	Mg2+ binding site [ion binding]; other site
483179001621	G-X-G motif; other site
483179001622	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
483179001623	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
483179001624	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
483179001625	Protein of unknown function (DUF1491); Region: DUF1491; cl11568
483179001626	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419
483179001627	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
483179001628	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
483179001629	Transglycosylase; Region: Transgly; cl07896
483179001630	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
483179001631	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179001632	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
483179001633	Uncharacterized conserved protein [Function unknown]; Region: COG5323
483179001634	Phage-related protein [Function unknown]; Region: COG4695; cl01923
483179001635	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
483179001636	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
483179001637	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
483179001638	Phage capsid family; Region: Phage_capsid; pfam05065
483179001639	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
483179001640	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
483179001641	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
483179001642	oligomerization interface [polypeptide binding]; other site
483179001643	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
483179001644	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
483179001645	Phage major tail protein 2; Region: Phage_tail_2; cl11463
483179001646	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
483179001647	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774
483179001648	Phage-related minor tail protein [Function unknown]; Region: COG5281
483179001649	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
483179001650	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
483179001651	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
483179001652	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
483179001653	NlpC/P60 family; Region: NLPC_P60; cl11438
483179001654	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
483179001655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179001656	active site
483179001657	phosphorylation site [posttranslational modification]
483179001658	intermolecular recognition site; other site
483179001659	dimerization interface [polypeptide binding]; other site
483179001660	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179001661	DNA binding site [nucleotide binding]
483179001662	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
483179001663	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
483179001664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179001665	ATP binding site [chemical binding]; other site
483179001666	Mg2+ binding site [ion binding]; other site
483179001667	G-X-G motif; other site
483179001668	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
483179001669	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
483179001670	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
483179001671	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
483179001672	CcmE; Region: CcmE; cl00994
483179001673	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
483179001674	Cytochrome C biogenesis protein; Region: CcmH; cl01179
483179001675	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
483179001676	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
483179001677	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
483179001678	protein binding site [polypeptide binding]; other site
483179001679	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
483179001680	protein binding site [polypeptide binding]; other site
483179001681	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
483179001682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179001683	active site
483179001684	phosphorylation site [posttranslational modification]
483179001685	intermolecular recognition site; other site
483179001686	dimerization interface [polypeptide binding]; other site
483179001687	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179001688	DNA binding site [nucleotide binding]
483179001689	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
483179001690	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
483179001691	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179001692	dimer interface [polypeptide binding]; other site
483179001693	phosphorylation site [posttranslational modification]
483179001694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179001695	ATP binding site [chemical binding]; other site
483179001696	Mg2+ binding site [ion binding]; other site
483179001697	G-X-G motif; other site
483179001698	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
483179001699	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
483179001700	metal binding triad; other site
483179001701	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
483179001702	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
483179001703	metal binding triad; other site
483179001704	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
483179001705	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
483179001706	O-Antigen ligase; Region: Wzy_C; cl04850
483179001707	PAS fold; Region: PAS_3; pfam08447
483179001708	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
483179001709	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
483179001710	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179001711	dimer interface [polypeptide binding]; other site
483179001712	phosphorylation site [posttranslational modification]
483179001713	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179001714	ATP binding site [chemical binding]; other site
483179001715	Mg2+ binding site [ion binding]; other site
483179001716	G-X-G motif; other site
483179001717	aminopeptidase N; Provisional; Region: pepN; PRK14015
483179001718	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
483179001719	active site
483179001720	Zn binding site [ion binding]; other site
483179001721	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
483179001722	EamA-like transporter family; Region: EamA; cl01037
483179001723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179001724	Major Facilitator Superfamily; Region: MFS_1; pfam07690
483179001725	putative substrate translocation pore; other site
483179001726	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
483179001727	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
483179001728	Fe-S cluster binding site [ion binding]; other site
483179001729	active site
483179001730	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
483179001731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179001732	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
483179001733	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
483179001734	putative catalytic site [active]
483179001735	putative metal binding site [ion binding]; other site
483179001736	putative phosphate binding site [ion binding]; other site
483179001737	AMP nucleosidase; Provisional; Region: PRK08292
483179001738	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
483179001739	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
483179001740	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
483179001741	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
483179001742	C-terminal domain interface [polypeptide binding]; other site
483179001743	GSH binding site (G-site) [chemical binding]; other site
483179001744	dimer interface [polypeptide binding]; other site
483179001745	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
483179001746	N-terminal domain interface [polypeptide binding]; other site
483179001747	putative dimer interface [polypeptide binding]; other site
483179001748	active site
483179001749	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
483179001750	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
483179001751	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
483179001752	Protein of unknown function (DUF423); Region: DUF423; cl01008
483179001753	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
483179001754	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
483179001755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179001756	homodimer interface [polypeptide binding]; other site
483179001757	catalytic residue [active]
483179001758	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
483179001759	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
483179001760	active site
483179001761	DNA binding site [nucleotide binding]
483179001762	Int/Topo IB signature motif; other site
483179001763	Porin subfamily; Region: Porin_2; pfam02530
483179001764	Porin subfamily; Region: Porin_2; pfam02530
483179001765	Uncharacterized conserved protein [Function unknown]; Region: COG3743
483179001766	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
483179001767	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
483179001768	N-acetyl-D-glucosamine binding site [chemical binding]; other site
483179001769	catalytic residue [active]
483179001770	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
483179001771	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
483179001772	dimer interface [polypeptide binding]; other site
483179001773	active site
483179001774	catalytic residue [active]
483179001775	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
483179001776	SmpB-tmRNA interface; other site
483179001777	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
483179001778	Fe-S cluster binding site [ion binding]; other site
483179001779	DNA binding site [nucleotide binding]
483179001780	active site
483179001781	Uncharacterized conserved protein [Function unknown]; Region: COG1432
483179001782	LabA_like proteins; Region: LabA; cd10911
483179001783	putative metal binding site [ion binding]; other site
483179001784	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
483179001785	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
483179001786	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
483179001787	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
483179001788	synthetase active site [active]
483179001789	NTP binding site [chemical binding]; other site
483179001790	metal binding site [ion binding]; metal-binding site
483179001791	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
483179001792	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
483179001793	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
483179001794	active site
483179001795	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
483179001796	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
483179001797	ligand binding site [chemical binding]; other site
483179001798	flexible hinge region; other site
483179001799	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
483179001800	putative switch regulator; other site
483179001801	non-specific DNA interactions [nucleotide binding]; other site
483179001802	DNA binding site [nucleotide binding]
483179001803	sequence specific DNA binding site [nucleotide binding]; other site
483179001804	putative cAMP binding site [chemical binding]; other site
483179001805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179001806	Major Facilitator Superfamily; Region: MFS_1; pfam07690
483179001807	putative substrate translocation pore; other site
483179001808	Cupin domain; Region: Cupin_2; cl09118
483179001809	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
483179001810	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
483179001811	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
483179001812	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
483179001813	Catalytic site [active]
483179001814	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
483179001815	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
483179001816	ribonuclease III; Reviewed; Region: PRK12371
483179001817	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
483179001818	dimerization interface [polypeptide binding]; other site
483179001819	active site
483179001820	metal binding site [ion binding]; metal-binding site
483179001821	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
483179001822	dsRNA binding site [nucleotide binding]; other site
483179001823	GTPase Era; Reviewed; Region: era; PRK00089
483179001824	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
483179001825	G1 box; other site
483179001826	GTP/Mg2+ binding site [chemical binding]; other site
483179001827	Switch I region; other site
483179001828	G2 box; other site
483179001829	Switch II region; other site
483179001830	G3 box; other site
483179001831	G4 box; other site
483179001832	G5 box; other site
483179001833	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
483179001834	Recombination protein O N terminal; Region: RecO_N; cl15812
483179001835	DNA repair protein RecO; Region: reco; TIGR00613
483179001836	Recombination protein O C terminal; Region: RecO_C; pfam02565
483179001837	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
483179001838	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
483179001839	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
483179001840	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
483179001841	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
483179001842	dihydroorotase; Validated; Region: PRK09060
483179001843	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
483179001844	active site
483179001845	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
483179001846	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
483179001847	nudix motif; other site
483179001848	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
483179001849	LysE type translocator; Region: LysE; cl00565
483179001850	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
483179001851	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
483179001852	active site
483179001853	HIGH motif; other site
483179001854	nucleotide binding site [chemical binding]; other site
483179001855	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
483179001856	KMSKS motif; other site
483179001857	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
483179001858	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
483179001859	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
483179001860	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
483179001861	active site
483179001862	catalytic residues [active]
483179001863	metal binding site [ion binding]; metal-binding site
483179001864	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
483179001865	Predicted permeases [General function prediction only]; Region: RarD; COG2962
483179001866	Peptidase family M23; Region: Peptidase_M23; pfam01551
483179001867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179001868	S-adenosylmethionine binding site [chemical binding]; other site
483179001869	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
483179001870	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
483179001871	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
483179001872	SurA N-terminal domain; Region: SurA_N_3; cl07813
483179001873	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
483179001874	OstA-like protein; Region: OstA; cl00844
483179001875	Organic solvent tolerance protein; Region: OstA_C; pfam04453
483179001876	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
483179001877	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
483179001878	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
483179001879	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
483179001880	multifunctional aminopeptidase A; Provisional; Region: PRK00913
483179001881	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
483179001882	interface (dimer of trimers) [polypeptide binding]; other site
483179001883	Substrate-binding/catalytic site; other site
483179001884	Zn-binding sites [ion binding]; other site
483179001885	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
483179001886	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
483179001887	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
483179001888	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
483179001889	ABC transporter; Region: ABC_tran_2; pfam12848
483179001890	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
483179001891	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
483179001892	DinB superfamily; Region: DinB_2; pfam12867
483179001893	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
483179001894	active site
483179001895	multimer interface [polypeptide binding]; other site
483179001896	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
483179001897	META domain; Region: META; cl01245
483179001898	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
483179001899	MoaE homodimer interface [polypeptide binding]; other site
483179001900	MoaD interaction [polypeptide binding]; other site
483179001901	active site residues [active]
483179001902	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
483179001903	MoaE interaction surface [polypeptide binding]; other site
483179001904	MoeB interaction surface [polypeptide binding]; other site
483179001905	thiocarboxylated glycine; other site
483179001906	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
483179001907	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
483179001908	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
483179001909	GIY-YIG motif/motif A; other site
483179001910	active site
483179001911	catalytic site [active]
483179001912	putative DNA binding site [nucleotide binding]; other site
483179001913	metal binding site [ion binding]; metal-binding site
483179001914	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
483179001915	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
483179001916	pteridine reductase; Provisional; Region: PRK09135
483179001917	NADP binding site [chemical binding]; other site
483179001918	substrate binding pocket [chemical binding]; other site
483179001919	active site
483179001920	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179001921	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
483179001922	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
483179001923	putative C-terminal domain interface [polypeptide binding]; other site
483179001924	putative GSH binding site (G-site) [chemical binding]; other site
483179001925	putative dimer interface [polypeptide binding]; other site
483179001926	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
483179001927	dimer interface [polypeptide binding]; other site
483179001928	N-terminal domain interface [polypeptide binding]; other site
483179001929	putative substrate binding pocket (H-site) [chemical binding]; other site
483179001930	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
483179001931	B1 nucleotide binding pocket [chemical binding]; other site
483179001932	B2 nucleotide binding pocket [chemical binding]; other site
483179001933	CAS motifs; other site
483179001934	active site
483179001935	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
483179001936	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179001937	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
483179001938	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
483179001939	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
483179001940	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
483179001941	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
483179001942	putative [4Fe-4S] binding site [ion binding]; other site
483179001943	putative molybdopterin cofactor binding site [chemical binding]; other site
483179001944	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
483179001945	putative molybdopterin cofactor binding site; other site
483179001946	Protein of unknown function (DUF992); Region: DUF992; pfam06186
483179001947	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
483179001948	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
483179001949	active site
483179001950	substrate binding site [chemical binding]; other site
483179001951	cosubstrate binding site; other site
483179001952	catalytic site [active]
483179001953	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
483179001954	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
483179001955	dimerization interface [polypeptide binding]; other site
483179001956	putative ATP binding site [chemical binding]; other site
483179001957	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
483179001958	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179001959	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
483179001960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179001961	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
483179001962	NAD(P) binding site [chemical binding]; other site
483179001963	active site
483179001964	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
483179001965	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
483179001966	putative NAD(P) binding site [chemical binding]; other site
483179001967	putative active site [active]
483179001968	glycolate transporter; Provisional; Region: PRK09695
483179001969	L-lactate permease; Region: Lactate_perm; cl00701
483179001970	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
483179001971	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
483179001972	active site
483179001973	catalytic site [active]
483179001974	substrate binding site [chemical binding]; other site
483179001975	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179001976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
483179001977	non-specific DNA binding site [nucleotide binding]; other site
483179001978	salt bridge; other site
483179001979	sequence-specific DNA binding site [nucleotide binding]; other site
483179001980	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
483179001981	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370
483179001982	Integrase core domain; Region: rve; cl01316
483179001983	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
483179001984	AAA domain; Region: AAA_22; pfam13401
483179001985	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179001986	TniQ; Region: TniQ; pfam06527
483179001987	Domain of unknown function (DUF955); Region: DUF955; cl01076
483179001988	TIR domain; Region: TIR_2; cl15770
483179001989	Bacterial SH3 domain; Region: SH3_3; cl02551
483179001990	cystathionine beta-lyase; Provisional; Region: PRK05967
483179001991	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
483179001992	homodimer interface [polypeptide binding]; other site
483179001993	substrate-cofactor binding pocket; other site
483179001994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179001995	catalytic residue [active]
483179001996	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
483179001997	active site
483179001998	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
483179001999	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
483179002000	substrate binding pocket [chemical binding]; other site
483179002001	membrane-bound complex binding site; other site
483179002002	hinge residues; other site
483179002003	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
483179002004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
483179002005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179002006	putative PBP binding loops; other site
483179002007	dimer interface [polypeptide binding]; other site
483179002008	ABC-ATPase subunit interface; other site
483179002009	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
483179002010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179002011	dimer interface [polypeptide binding]; other site
483179002012	conserved gate region; other site
483179002013	putative PBP binding loops; other site
483179002014	ABC-ATPase subunit interface; other site
483179002015	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
483179002016	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
483179002017	Walker A/P-loop; other site
483179002018	ATP binding site [chemical binding]; other site
483179002019	Q-loop/lid; other site
483179002020	ABC transporter signature motif; other site
483179002021	Walker B; other site
483179002022	D-loop; other site
483179002023	H-loop/switch region; other site
483179002024	salicylate hydroxylase; Provisional; Region: PRK06475
483179002025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002026	Zinc-finger domain; Region: zf-CHCC; cl01821
483179002027	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
483179002028	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
483179002029	ribonuclease D; Region: rnd; TIGR01388
483179002030	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
483179002031	catalytic site [active]
483179002032	putative active site [active]
483179002033	putative substrate binding site [chemical binding]; other site
483179002034	HRDC domain; Region: HRDC; cl02578
483179002035	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
483179002036	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
483179002037	dimer interface [polypeptide binding]; other site
483179002038	anticodon binding site; other site
483179002039	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
483179002040	homodimer interface [polypeptide binding]; other site
483179002041	motif 1; other site
483179002042	active site
483179002043	motif 2; other site
483179002044	GAD domain; Region: GAD; pfam02938
483179002045	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
483179002046	active site
483179002047	motif 3; other site
483179002048	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
483179002049	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
483179002050	CAP-like domain; other site
483179002051	active site
483179002052	primary dimer interface [polypeptide binding]; other site
483179002053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
483179002054	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
483179002055	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
483179002056	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179002057	RDD family; Region: RDD; cl00746
483179002058	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
483179002059	dimer interface [polypeptide binding]; other site
483179002060	allosteric magnesium binding site [ion binding]; other site
483179002061	active site
483179002062	aspartate-rich active site metal binding site; other site
483179002063	Schiff base residues; other site
483179002064	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
483179002065	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
483179002066	substrate binding site [chemical binding]; other site
483179002067	oxyanion hole (OAH) forming residues; other site
483179002068	trimer interface [polypeptide binding]; other site
483179002069	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
483179002070	Transcriptional regulators [Transcription]; Region: MarR; COG1846
483179002071	Helix-turn-helix domains; Region: HTH; cl00088
483179002072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
483179002073	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
483179002074	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179002075	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179002076	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
483179002077	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
483179002078	dimer interface [polypeptide binding]; other site
483179002079	active site
483179002080	glycine-pyridoxal phosphate binding site [chemical binding]; other site
483179002081	folate binding site [chemical binding]; other site
483179002082	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
483179002083	ATP cone domain; Region: ATP-cone; pfam03477
483179002084	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
483179002085	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
483179002086	catalytic motif [active]
483179002087	Zn binding site [ion binding]; other site
483179002088	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
483179002089	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
483179002090	Lumazine binding domain; Region: Lum_binding; pfam00677
483179002091	Lumazine binding domain; Region: Lum_binding; pfam00677
483179002092	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
483179002093	homopentamer interface [polypeptide binding]; other site
483179002094	active site
483179002095	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
483179002096	putative RNA binding site [nucleotide binding]; other site
483179002097	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
483179002098	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
483179002099	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
483179002100	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
483179002101	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
483179002102	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
483179002103	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
483179002104	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
483179002105	dimer interface [polypeptide binding]; other site
483179002106	active site
483179002107	CoA binding pocket [chemical binding]; other site
483179002108	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
483179002109	IHF dimer interface [polypeptide binding]; other site
483179002110	IHF - DNA interface [nucleotide binding]; other site
483179002111	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
483179002112	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
483179002113	DNA binding residues [nucleotide binding]
483179002114	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
483179002115	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
483179002116	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
483179002117	SLBB domain; Region: SLBB; pfam10531
483179002118	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
483179002119	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
483179002120	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
483179002121	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
483179002122	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
483179002123	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002124	Arginase family; Region: Arginase; cl00306
483179002125	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
483179002126	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
483179002127	23S rRNA interface [nucleotide binding]; other site
483179002128	L3 interface [polypeptide binding]; other site
483179002129	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
483179002130	CoenzymeA binding site [chemical binding]; other site
483179002131	subunit interaction site [polypeptide binding]; other site
483179002132	PHB binding site; other site
483179002133	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
483179002134	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
483179002135	homodimer interface [polypeptide binding]; other site
483179002136	substrate-cofactor binding pocket; other site
483179002137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179002138	catalytic residue [active]
483179002139	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
483179002140	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
483179002141	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
483179002142	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
483179002143	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
483179002144	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
483179002145	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
483179002146	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
483179002147	putative dimer interface [polypeptide binding]; other site
483179002148	[2Fe-2S] cluster binding site [ion binding]; other site
483179002149	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
483179002150	SLBB domain; Region: SLBB; pfam10531
483179002151	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
483179002152	NADH dehydrogenase subunit G; Validated; Region: PRK09130
483179002153	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
483179002154	catalytic loop [active]
483179002155	iron binding site [ion binding]; other site
483179002156	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
483179002157	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
483179002158	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
483179002159	NADH dehydrogenase; Region: NADHdh; cl00469
483179002160	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
483179002161	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
483179002162	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
483179002163	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
483179002164	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
483179002165	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
483179002166	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
483179002167	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
483179002168	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
483179002169	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
483179002170	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
483179002171	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
483179002172	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
483179002173	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
483179002174	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
483179002175	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
483179002176	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179002177	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
483179002178	dimer interface [polypeptide binding]; other site
483179002179	substrate binding site [chemical binding]; other site
483179002180	metal binding site [ion binding]; metal-binding site
483179002181	Protein of unknown function (DUF1467); Region: DUF1467; cl11569
483179002182	prolyl-tRNA synthetase; Provisional; Region: PRK12325
483179002183	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
483179002184	dimer interface [polypeptide binding]; other site
483179002185	motif 1; other site
483179002186	active site
483179002187	motif 2; other site
483179002188	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
483179002189	active site
483179002190	motif 3; other site
483179002191	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
483179002192	anticodon binding site; other site
483179002193	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
483179002194	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
483179002195	FtsX-like permease family; Region: FtsX; cl15850
483179002196	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
483179002197	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
483179002198	Walker A/P-loop; other site
483179002199	ATP binding site [chemical binding]; other site
483179002200	Q-loop/lid; other site
483179002201	ABC transporter signature motif; other site
483179002202	Walker B; other site
483179002203	D-loop; other site
483179002204	H-loop/switch region; other site
483179002205	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
483179002206	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
483179002207	Protein of unknown function, DUF655; Region: DUF655; pfam04919
483179002208	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
483179002209	generic binding surface II; other site
483179002210	generic binding surface I; other site
483179002211	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
483179002212	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
483179002213	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
483179002214	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
483179002215	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
483179002216	RNA binding surface [nucleotide binding]; other site
483179002217	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
483179002218	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
483179002219	Ligand Binding Site [chemical binding]; other site
483179002220	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
483179002221	active site
483179002222	putative lithium-binding site [ion binding]; other site
483179002223	substrate binding site [chemical binding]; other site
483179002224	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
483179002225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179002226	putative substrate translocation pore; other site
483179002227	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
483179002228	putative GSH binding site [chemical binding]; other site
483179002229	catalytic residues [active]
483179002230	BolA-like protein; Region: BolA; cl00386
483179002231	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
483179002232	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
483179002233	dimerization interface [polypeptide binding]; other site
483179002234	ATP binding site [chemical binding]; other site
483179002235	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
483179002236	dimerization interface [polypeptide binding]; other site
483179002237	ATP binding site [chemical binding]; other site
483179002238	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
483179002239	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
483179002240	C-terminal domain interface [polypeptide binding]; other site
483179002241	GSH binding site (G-site) [chemical binding]; other site
483179002242	dimer interface [polypeptide binding]; other site
483179002243	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
483179002244	N-terminal domain interface [polypeptide binding]; other site
483179002245	dimer interface [polypeptide binding]; other site
483179002246	substrate binding pocket (H-site) [chemical binding]; other site
483179002247	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
483179002248	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
483179002249	putative active site [active]
483179002250	catalytic triad [active]
483179002251	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
483179002252	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
483179002253	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
483179002254	ATP binding site [chemical binding]; other site
483179002255	active site
483179002256	substrate binding site [chemical binding]; other site
483179002257	Domain of unknown function (DUF1476); Region: DUF1476; cl11571
483179002258	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
483179002259	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
483179002260	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179002261	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
483179002262	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
483179002263	putative metal binding site [ion binding]; other site
483179002264	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
483179002265	active site
483179002266	adenylosuccinate lyase; Provisional; Region: PRK07492
483179002267	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
483179002268	tetramer interface [polypeptide binding]; other site
483179002269	active site
483179002270	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
483179002271	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
483179002272	substrate binding site [chemical binding]; other site
483179002273	hexamer interface [polypeptide binding]; other site
483179002274	metal binding site [ion binding]; metal-binding site
483179002275	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
483179002276	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
483179002277	putative acyl-acceptor binding pocket; other site
483179002278	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
483179002279	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
483179002280	putative NAD(P) binding site [chemical binding]; other site
483179002281	structural Zn binding site [ion binding]; other site
483179002282	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
483179002283	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
483179002284	dimer interface [polypeptide binding]; other site
483179002285	active site
483179002286	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
483179002287	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
483179002288	active site
483179002289	Phosphopantetheine attachment site; Region: PP-binding; cl09936
483179002290	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
483179002291	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
483179002292	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
483179002293	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
483179002294	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
483179002295	active site
483179002296	catalytic residues [active]
483179002297	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
483179002298	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
483179002299	substrate binding site [chemical binding]; other site
483179002300	ATP binding site [chemical binding]; other site
483179002301	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
483179002302	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
483179002303	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
483179002304	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
483179002305	active site
483179002306	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179002307	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
483179002308	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
483179002309	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
483179002310	FMN binding site [chemical binding]; other site
483179002311	active site
483179002312	catalytic residues [active]
483179002313	substrate binding site [chemical binding]; other site
483179002314	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
483179002315	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
483179002316	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
483179002317	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
483179002318	putative dimer interface [polypeptide binding]; other site
483179002319	active site pocket [active]
483179002320	putative cataytic base [active]
483179002321	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
483179002322	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179002323	putative DNA binding site [nucleotide binding]; other site
483179002324	putative Zn2+ binding site [ion binding]; other site
483179002325	AsnC family; Region: AsnC_trans_reg; pfam01037
483179002326	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
483179002327	putative uracil binding site [chemical binding]; other site
483179002328	putative active site [active]
483179002329	Staphylococcal nuclease homologues; Region: SNc; smart00318
483179002330	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
483179002331	Catalytic site; other site
483179002332	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
483179002333	Sel1 repeat; Region: Sel1; cl02723
483179002334	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
483179002335	putative catalytic site [active]
483179002336	putative phosphate binding site [ion binding]; other site
483179002337	active site
483179002338	metal binding site A [ion binding]; metal-binding site
483179002339	DNA binding site [nucleotide binding]
483179002340	putative AP binding site [nucleotide binding]; other site
483179002341	putative metal binding site B [ion binding]; other site
483179002342	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
483179002343	putative metal binding site [ion binding]; other site
483179002344	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
483179002345	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
483179002346	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
483179002347	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
483179002348	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
483179002349	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
483179002350	active site
483179002351	HIGH motif; other site
483179002352	KMSK motif region; other site
483179002353	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
483179002354	tRNA binding surface [nucleotide binding]; other site
483179002355	anticodon binding site; other site
483179002356	Sporulation related domain; Region: SPOR; cl10051
483179002357	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
483179002358	ScpA/B protein; Region: ScpA_ScpB; cl00598
483179002359	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
483179002360	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
483179002361	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
483179002362	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
483179002363	seryl-tRNA synthetase; Provisional; Region: PRK05431
483179002364	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
483179002365	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
483179002366	dimer interface [polypeptide binding]; other site
483179002367	active site
483179002368	motif 1; other site
483179002369	motif 2; other site
483179002370	motif 3; other site
483179002371	Survival protein SurE; Region: SurE; cl00448
483179002372	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
483179002373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179002374	S-adenosylmethionine binding site [chemical binding]; other site
483179002375	autolysin; Reviewed; Region: PRK06347
483179002376	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
483179002377	Peptidase family M23; Region: Peptidase_M23; pfam01551
483179002378	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
483179002379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179002380	Walker A motif; other site
483179002381	ATP binding site [chemical binding]; other site
483179002382	Walker B motif; other site
483179002383	Preprotein translocase subunit; Region: YajC; cl00806
483179002384	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023
483179002385	Protein export membrane protein; Region: SecD_SecF; cl14618
483179002386	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
483179002387	Protein export membrane protein; Region: SecD_SecF; cl14618
483179002388	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
483179002389	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
483179002390	substrate binding pocket [chemical binding]; other site
483179002391	substrate-Mg2+ binding site; other site
483179002392	aspartate-rich region 1; other site
483179002393	aspartate-rich region 2; other site
483179002394	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
483179002395	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002396	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
483179002397	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
483179002398	GDYXXLXY protein; Region: GDYXXLXY; cl02066
483179002399	trigger factor; Provisional; Region: tig; PRK01490
483179002400	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
483179002401	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
483179002402	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
483179002403	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
483179002404	GatB domain; Region: GatB_Yqey; cl11497
483179002405	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
483179002406	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179002407	NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534
483179002408	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
483179002409	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179002410	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
483179002411	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
483179002412	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179002413	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
483179002414	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
483179002415	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
483179002416	carboxyltransferase (CT) interaction site; other site
483179002417	biotinylation site [posttranslational modification]; other site
483179002418	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
483179002419	trimer interface [polypeptide binding]; other site
483179002420	active site
483179002421	dimer interface [polypeptide binding]; other site
483179002422	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
483179002423	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
483179002424	catalytic residues [active]
483179002425	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
483179002426	Peptidase family M48; Region: Peptidase_M48; cl12018
483179002427	aspartate aminotransferase; Provisional; Region: PRK05764
483179002428	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
483179002429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179002430	homodimer interface [polypeptide binding]; other site
483179002431	catalytic residue [active]
483179002432	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
483179002433	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
483179002434	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
483179002435	AMIN domain; Region: AMIN; pfam11741
483179002436	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
483179002437	active site
483179002438	metal binding site [ion binding]; metal-binding site
483179002439	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
483179002440	Transglycosylase; Region: Transgly; cl07896
483179002441	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179002442	peptide chain release factor 2; Provisional; Region: PRK07342
483179002443	RF-1 domain; Region: RF-1; cl02875
483179002444	RF-1 domain; Region: RF-1; cl02875
483179002445	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179002446	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179002447	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
483179002448	dinuclear metal binding motif [ion binding]; other site
483179002449	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
483179002450	catalytic triad [active]
483179002451	AsmA family; Region: AsmA; pfam05170
483179002452	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
483179002453	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
483179002454	active site
483179002455	HIGH motif; other site
483179002456	dimer interface [polypeptide binding]; other site
483179002457	KMSKS motif; other site
483179002458	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
483179002459	RNA binding surface [nucleotide binding]; other site
483179002460	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
483179002461	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
483179002462	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
483179002463	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
483179002464	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
483179002465	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
483179002466	catalytic residue [active]
483179002467	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
483179002468	putative ABC transporter; Region: ycf24; CHL00085
483179002469	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
483179002470	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
483179002471	Walker A/P-loop; other site
483179002472	ATP binding site [chemical binding]; other site
483179002473	Q-loop/lid; other site
483179002474	ABC transporter signature motif; other site
483179002475	Walker B; other site
483179002476	D-loop; other site
483179002477	H-loop/switch region; other site
483179002478	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
483179002479	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
483179002480	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
483179002481	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
483179002482	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
483179002483	catalytic residue [active]
483179002484	Domain of unknown function DUF59; Region: DUF59; cl00941
483179002485	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
483179002486	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
483179002487	active site
483179002488	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
483179002489	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
483179002490	helicase 45; Provisional; Region: PTZ00424
483179002491	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
483179002492	ATP binding site [chemical binding]; other site
483179002493	Mg++ binding site [ion binding]; other site
483179002494	motif III; other site
483179002495	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
483179002496	nucleotide binding region [chemical binding]; other site
483179002497	ATP-binding site [chemical binding]; other site
483179002498	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
483179002499	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
483179002500	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
483179002501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179002502	S-adenosylmethionine binding site [chemical binding]; other site
483179002503	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
483179002504	Protein of unknown function (DUF2497); Region: DUF2497; cl11534
483179002505	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
483179002506	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
483179002507	HIGH motif; other site
483179002508	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
483179002509	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
483179002510	active site
483179002511	KMSKS motif; other site
483179002512	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
483179002513	tRNA binding surface [nucleotide binding]; other site
483179002514	anticodon binding site; other site
483179002515	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
483179002516	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179002517	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002518	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
483179002519	NAD(P) binding pocket [chemical binding]; other site
483179002520	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
483179002521	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
483179002522	putative C-terminal domain interface [polypeptide binding]; other site
483179002523	putative GSH binding site (G-site) [chemical binding]; other site
483179002524	putative dimer interface [polypeptide binding]; other site
483179002525	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
483179002526	putative N-terminal domain interface [polypeptide binding]; other site
483179002527	putative dimer interface [polypeptide binding]; other site
483179002528	putative substrate binding pocket (H-site) [chemical binding]; other site
483179002529	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
483179002530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179002531	dimer interface [polypeptide binding]; other site
483179002532	conserved gate region; other site
483179002533	putative PBP binding loops; other site
483179002534	ABC-ATPase subunit interface; other site
483179002535	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
483179002536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179002537	dimer interface [polypeptide binding]; other site
483179002538	conserved gate region; other site
483179002539	putative PBP binding loops; other site
483179002540	ABC-ATPase subunit interface; other site
483179002541	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
483179002542	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
483179002543	substrate binding pocket [chemical binding]; other site
483179002544	membrane-bound complex binding site; other site
483179002545	hinge residues; other site
483179002546	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
483179002547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179002548	FeS/SAM binding site; other site
483179002549	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
483179002550	Protein of unknown function (DUF971); Region: DUF971; cl01414
483179002551	hypothetical protein; Provisional; Region: PRK06753
483179002552	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002553	fumarate hydratase; Provisional; Region: PRK15389
483179002554	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
483179002555	Fumarase C-terminus; Region: Fumerase_C; cl00795
483179002556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
483179002557	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
483179002558	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179002559	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
483179002560	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
483179002561	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
483179002562	active site
483179002563	Int/Topo IB signature motif; other site
483179002564	catalytic residues [active]
483179002565	DNA binding site [nucleotide binding]
483179002566	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
483179002567	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
483179002568	Protein of unknown function (DUF497); Region: DUF497; cl01108
483179002569	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
483179002570	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179002571	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179002572	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
483179002573	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
483179002574	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
483179002575	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
483179002576	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
483179002577	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
483179002578	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
483179002579	ArsC family; Region: ArsC; pfam03960
483179002580	catalytic residues [active]
483179002581	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
483179002582	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
483179002583	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
483179002584	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179002585	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
483179002586	thymidylate kinase; Validated; Region: tmk; PRK00698
483179002587	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
483179002588	TMP-binding site; other site
483179002589	ATP-binding site [chemical binding]; other site
483179002590	DNA polymerase III subunit delta'; Validated; Region: PRK09112
483179002591	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179002592	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179002593	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
483179002594	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
483179002595	active site
483179002596	HIGH motif; other site
483179002597	KMSKS motif; other site
483179002598	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
483179002599	tRNA binding surface [nucleotide binding]; other site
483179002600	anticodon binding site; other site
483179002601	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
483179002602	active site
483179002603	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
483179002604	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
483179002605	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179002606	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
483179002607	Walker A/P-loop; other site
483179002608	ATP binding site [chemical binding]; other site
483179002609	Q-loop/lid; other site
483179002610	ABC transporter signature motif; other site
483179002611	Walker B; other site
483179002612	D-loop; other site
483179002613	H-loop/switch region; other site
483179002614	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
483179002615	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
483179002616	active site
483179002617	EamA-like transporter family; Region: EamA; cl01037
483179002618	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
483179002619	EamA-like transporter family; Region: EamA; cl01037
483179002620	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
483179002621	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179002622	motif I; other site
483179002623	active site
483179002624	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179002625	motif II; other site
483179002626	ATP12 chaperone protein; Region: ATP12; cl02228
483179002627	glutamine synthetase; Provisional; Region: glnA; PRK09469
483179002628	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
483179002629	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
483179002630	Nitrogen regulatory protein P-II; Region: P-II; cl00412
483179002631	Nitrogen regulatory protein P-II; Region: P-II; smart00938
483179002632	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
483179002633	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
483179002634	putative substrate binding site [chemical binding]; other site
483179002635	putative ATP binding site [chemical binding]; other site
483179002636	phosphoglycolate phosphatase; Provisional; Region: PRK13222
483179002637	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179002638	motif II; other site
483179002639	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
483179002640	tetramer (dimer of dimers) interface [polypeptide binding]; other site
483179002641	active site
483179002642	dimer interface [polypeptide binding]; other site
483179002643	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
483179002644	glutathione reductase; Validated; Region: PRK06116
483179002645	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179002646	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
483179002647	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
483179002648	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
483179002649	NAD synthetase; Provisional; Region: PRK13981
483179002650	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
483179002651	multimer interface [polypeptide binding]; other site
483179002652	active site
483179002653	catalytic triad [active]
483179002654	protein interface 1 [polypeptide binding]; other site
483179002655	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
483179002656	homodimer interface [polypeptide binding]; other site
483179002657	NAD binding pocket [chemical binding]; other site
483179002658	ATP binding pocket [chemical binding]; other site
483179002659	Mg binding site [ion binding]; other site
483179002660	active-site loop [active]
483179002661	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
483179002662	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
483179002663	active site
483179002664	HIGH motif; other site
483179002665	nucleotide binding site [chemical binding]; other site
483179002666	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
483179002667	active site
483179002668	KMSKS motif; other site
483179002669	malic enzyme; Reviewed; Region: PRK12862
483179002670	Malic enzyme, N-terminal domain; Region: malic; pfam00390
483179002671	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
483179002672	putative NAD(P) binding site [chemical binding]; other site
483179002673	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
483179002674	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
483179002675	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
483179002676	active site
483179002677	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
483179002678	Permease; Region: Permease; cl00510
483179002679	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
483179002680	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
483179002681	Walker A/P-loop; other site
483179002682	ATP binding site [chemical binding]; other site
483179002683	Q-loop/lid; other site
483179002684	ABC transporter signature motif; other site
483179002685	Walker B; other site
483179002686	D-loop; other site
483179002687	H-loop/switch region; other site
483179002688	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
483179002689	mce related protein; Region: MCE; pfam02470
483179002690	Protein of unknown function (DUF330); Region: DUF330; cl01135
483179002691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
483179002692	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
483179002693	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
483179002694	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
483179002695	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
483179002696	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
483179002697	dihydropteroate synthase; Region: DHPS; TIGR01496
483179002698	substrate binding pocket [chemical binding]; other site
483179002699	dimer interface [polypeptide binding]; other site
483179002700	inhibitor binding site; inhibition site
483179002701	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
483179002702	homooctamer interface [polypeptide binding]; other site
483179002703	active site
483179002704	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
483179002705	catalytic center binding site [active]
483179002706	ATP binding site [chemical binding]; other site
483179002707	Predicted membrane protein [Function unknown]; Region: COG3768
483179002708	Domain of unknown function (DUF697); Region: DUF697; cl12064
483179002709	YcjX-like family, DUF463; Region: DUF463; cl01193
483179002710	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
483179002711	catalytic core [active]
483179002712	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
483179002713	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
483179002714	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
483179002715	putative active site [active]
483179002716	heme pocket [chemical binding]; other site
483179002717	PAS fold; Region: PAS_4; pfam08448
483179002718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179002719	dimer interface [polypeptide binding]; other site
483179002720	phosphorylation site [posttranslational modification]
483179002721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179002722	ATP binding site [chemical binding]; other site
483179002723	Mg2+ binding site [ion binding]; other site
483179002724	G-X-G motif; other site
483179002725	Response regulator receiver domain; Region: Response_reg; pfam00072
483179002726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179002727	active site
483179002728	phosphorylation site [posttranslational modification]
483179002729	intermolecular recognition site; other site
483179002730	dimerization interface [polypeptide binding]; other site
483179002731	Predicted flavoproteins [General function prediction only]; Region: COG2081
483179002732	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002733	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002734	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179002735	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
483179002736	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
483179002737	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
483179002738	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
483179002739	active site
483179002740	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
483179002741	TSCPD domain; Region: TSCPD; cl14834
483179002742	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
483179002743	nudix motif; other site
483179002744	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
483179002745	active site
483179002746	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
483179002747	Ligand Binding Site [chemical binding]; other site
483179002748	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
483179002749	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
483179002750	putative MPT binding site; other site
483179002751	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
483179002752	threonine dehydratase; Validated; Region: PRK08639
483179002753	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
483179002754	tetramer interface [polypeptide binding]; other site
483179002755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179002756	catalytic residue [active]
483179002757	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
483179002758	putative Ile/Val binding site [chemical binding]; other site
483179002759	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
483179002760	DEAD-like helicases superfamily; Region: DEXDc; smart00487
483179002761	ATP binding site [chemical binding]; other site
483179002762	Mg++ binding site [ion binding]; other site
483179002763	motif III; other site
483179002764	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
483179002765	nucleotide binding region [chemical binding]; other site
483179002766	ATP-binding site [chemical binding]; other site
483179002767	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
483179002768	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
483179002769	dimer interface [polypeptide binding]; other site
483179002770	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179002771	catalytic residue [active]
483179002772	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
483179002773	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
483179002774	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
483179002775	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
483179002776	active site residue [active]
483179002777	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
483179002778	active site residue [active]
483179002779	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
483179002780	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
483179002781	Coenzyme A binding pocket [chemical binding]; other site
483179002782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179002783	metal binding site [ion binding]; metal-binding site
483179002784	active site
483179002785	I-site; other site
483179002786	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
483179002787	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
483179002788	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
483179002789	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
483179002790	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179002791	putative substrate translocation pore; other site
483179002792	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
483179002793	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179002794	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179002795	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
483179002796	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
483179002797	putative NAD(P) binding site [chemical binding]; other site
483179002798	putative substrate binding site [chemical binding]; other site
483179002799	catalytic Zn binding site [ion binding]; other site
483179002800	structural Zn binding site [ion binding]; other site
483179002801	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
483179002802	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
483179002803	active site
483179002804	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
483179002805	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
483179002806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179002807	S-adenosylmethionine binding site [chemical binding]; other site
483179002808	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
483179002809	Membrane transport protein; Region: Mem_trans; cl09117
483179002810	UDP-glucose 4-epimerase; Region: PLN02240
483179002811	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
483179002812	NAD binding site [chemical binding]; other site
483179002813	homodimer interface [polypeptide binding]; other site
483179002814	active site
483179002815	substrate binding site [chemical binding]; other site
483179002816	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
483179002817	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
483179002818	homodimer interface [polypeptide binding]; other site
483179002819	metal binding site [ion binding]; metal-binding site
483179002820	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529
483179002821	homodimer interface [polypeptide binding]; other site
483179002822	active site
483179002823	putative chemical substrate binding site [chemical binding]; other site
483179002824	metal binding site [ion binding]; metal-binding site
483179002825	Flavin Reductases; Region: FlaRed; cl00801
483179002826	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
483179002827	putative FMN binding site [chemical binding]; other site
483179002828	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
483179002829	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
483179002830	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
483179002831	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
483179002832	active site
483179002833	dimer interface [polypeptide binding]; other site
483179002834	motif 1; other site
483179002835	motif 2; other site
483179002836	motif 3; other site
483179002837	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
483179002838	anticodon binding site; other site
483179002839	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
483179002840	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179002841	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
483179002842	Sporulation related domain; Region: SPOR; cl10051
483179002843	Haemolytic domain; Region: Haemolytic; cl00506
483179002844	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
483179002845	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
483179002846	trimerization site [polypeptide binding]; other site
483179002847	active site
483179002848	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
483179002849	homodecamer interface [polypeptide binding]; other site
483179002850	GTP cyclohydrolase I; Provisional; Region: PLN03044
483179002851	active site
483179002852	putative catalytic site residues [active]
483179002853	zinc binding site [ion binding]; other site
483179002854	GTP-CH-I/GFRP interaction surface; other site
483179002855	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
483179002856	hypothetical protein; Provisional; Region: PRK10279
483179002857	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
483179002858	nucleophile elbow; other site
483179002859	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
483179002860	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
483179002861	active site
483179002862	DNA binding site [nucleotide binding]
483179002863	Int/Topo IB signature motif; other site
483179002864	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
483179002865	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
483179002866	catalytic residues [active]
483179002867	catalytic nucleophile [active]
483179002868	Presynaptic Site I dimer interface [polypeptide binding]; other site
483179002869	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
483179002870	Synaptic Flat tetramer interface [polypeptide binding]; other site
483179002871	Synaptic Site I dimer interface [polypeptide binding]; other site
483179002872	DNA binding site [nucleotide binding]
483179002873	BRO family, N-terminal domain; Region: Bro-N; cl10591
483179002874	Prophage antirepressor [Transcription]; Region: COG3617
483179002875	BRO family, N-terminal domain; Region: Bro-N; cl10591
483179002876	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
483179002877	CoA-transferase family III; Region: CoA_transf_3; pfam02515
483179002878	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
483179002879	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
483179002880	FAD binding site [chemical binding]; other site
483179002881	substrate binding pocket [chemical binding]; other site
483179002882	catalytic base [active]
483179002883	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
483179002884	Helix-turn-helix domains; Region: HTH; cl00088
483179002885	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
483179002886	dimerization interface [polypeptide binding]; other site
483179002887	substrate binding pocket [chemical binding]; other site
483179002888	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
483179002889	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
483179002890	multidrug efflux protein; Reviewed; Region: PRK09579
483179002891	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
483179002892	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179002893	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179002894	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
483179002895	Helix-turn-helix domains; Region: HTH; cl00088
483179002896	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
483179002897	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
483179002898	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
483179002899	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
483179002900	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
483179002901	active site
483179002902	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
483179002903	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
483179002904	active site
483179002905	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
483179002906	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
483179002907	active site
483179002908	(T/H)XGH motif; other site
483179002909	DNA gyrase subunit A; Validated; Region: PRK05560
483179002910	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
483179002911	CAP-like domain; other site
483179002912	active site
483179002913	primary dimer interface [polypeptide binding]; other site
483179002914	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
483179002915	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
483179002916	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
483179002917	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
483179002918	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
483179002919	MarC family integral membrane protein; Region: MarC; cl00919
483179002920	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179002921	active site
483179002922	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
483179002923	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
483179002924	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179002925	DNA-binding site [nucleotide binding]; DNA binding site
483179002926	UTRA domain; Region: UTRA; cl01230
483179002927	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
483179002928	dimer interface [polypeptide binding]; other site
483179002929	ssDNA binding site [nucleotide binding]; other site
483179002930	tetramer (dimer of dimers) interface [polypeptide binding]; other site
483179002931	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
483179002932	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
483179002933	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
483179002934	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
483179002935	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
483179002936	IHF dimer interface [polypeptide binding]; other site
483179002937	IHF - DNA interface [nucleotide binding]; other site
483179002938	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
483179002939	Found in ATP-dependent protease La (LON); Region: LON; smart00464
483179002940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179002941	Walker A motif; other site
483179002942	ATP binding site [chemical binding]; other site
483179002943	Walker B motif; other site
483179002944	arginine finger; other site
483179002945	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
483179002946	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
483179002947	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
483179002948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179002949	Walker A motif; other site
483179002950	ATP binding site [chemical binding]; other site
483179002951	Walker B motif; other site
483179002952	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
483179002953	Clp protease; Region: CLP_protease; pfam00574
483179002954	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
483179002955	oligomer interface [polypeptide binding]; other site
483179002956	active site residues [active]
483179002957	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
483179002958	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
483179002959	HflX GTPase family; Region: HflX; cd01878
483179002960	G1 box; other site
483179002961	GTP/Mg2+ binding site [chemical binding]; other site
483179002962	Switch I region; other site
483179002963	G2 box; other site
483179002964	G3 box; other site
483179002965	Switch II region; other site
483179002966	G4 box; other site
483179002967	G5 box; other site
483179002968	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
483179002969	Sm1 motif; other site
483179002970	intra - hexamer interaction site; other site
483179002971	inter - hexamer interaction site [polypeptide binding]; other site
483179002972	nucleotide binding pocket [chemical binding]; other site
483179002973	Sm2 motif; other site
483179002974	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
483179002975	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
483179002976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002977	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
483179002978	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179002979	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
483179002980	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
483179002981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179002982	active site
483179002983	phosphorylation site [posttranslational modification]
483179002984	intermolecular recognition site; other site
483179002985	dimerization interface [polypeptide binding]; other site
483179002986	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179002987	Walker A motif; other site
483179002988	ATP binding site [chemical binding]; other site
483179002989	Walker B motif; other site
483179002990	arginine finger; other site
483179002991	Helix-turn-helix domains; Region: HTH; cl00088
483179002992	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
483179002993	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
483179002994	dimerization interface [polypeptide binding]; other site
483179002995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
483179002996	putative active site [active]
483179002997	heme pocket [chemical binding]; other site
483179002998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179002999	dimer interface [polypeptide binding]; other site
483179003000	phosphorylation site [posttranslational modification]
483179003001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179003002	ATP binding site [chemical binding]; other site
483179003003	Mg2+ binding site [ion binding]; other site
483179003004	G-X-G motif; other site
483179003005	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
483179003006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179003007	active site
483179003008	phosphorylation site [posttranslational modification]
483179003009	intermolecular recognition site; other site
483179003010	dimerization interface [polypeptide binding]; other site
483179003011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179003012	Walker A motif; other site
483179003013	ATP binding site [chemical binding]; other site
483179003014	Walker B motif; other site
483179003015	arginine finger; other site
483179003016	Helix-turn-helix domains; Region: HTH; cl00088
483179003017	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
483179003018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179003019	dimer interface [polypeptide binding]; other site
483179003020	phosphorylation site [posttranslational modification]
483179003021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179003022	ATP binding site [chemical binding]; other site
483179003023	Mg2+ binding site [ion binding]; other site
483179003024	G-X-G motif; other site
483179003025	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
483179003026	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
483179003027	FMN binding site [chemical binding]; other site
483179003028	active site
483179003029	catalytic residues [active]
483179003030	substrate binding site [chemical binding]; other site
483179003031	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
483179003032	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
483179003033	substrate binding site; other site
483179003034	dimer interface; other site
483179003035	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
483179003036	homotrimer interaction site [polypeptide binding]; other site
483179003037	zinc binding site [ion binding]; other site
483179003038	CDP-binding sites; other site
483179003039	Competence-damaged protein; Region: CinA; cl00666
483179003040	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
483179003041	classical (c) SDRs; Region: SDR_c; cd05233
483179003042	NAD(P) binding site [chemical binding]; other site
483179003043	active site
483179003044	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
483179003045	putative coenzyme Q binding site [chemical binding]; other site
483179003046	lipoyl synthase; Provisional; Region: PRK05481
483179003047	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179003048	FeS/SAM binding site; other site
483179003049	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
483179003050	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
483179003051	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179003052	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
483179003053	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
483179003054	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
483179003055	E3 interaction surface; other site
483179003056	lipoyl attachment site [posttranslational modification]; other site
483179003057	e3 binding domain; Region: E3_binding; pfam02817
483179003058	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
483179003059	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
483179003060	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
483179003061	E3 interaction surface; other site
483179003062	lipoyl attachment site [posttranslational modification]; other site
483179003063	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
483179003064	alpha subunit interface [polypeptide binding]; other site
483179003065	TPP binding site [chemical binding]; other site
483179003066	heterodimer interface [polypeptide binding]; other site
483179003067	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
483179003068	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
483179003069	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
483179003070	tetramer interface [polypeptide binding]; other site
483179003071	TPP-binding site [chemical binding]; other site
483179003072	heterodimer interface [polypeptide binding]; other site
483179003073	phosphorylation loop region [posttranslational modification]
483179003074	Septum formation initiator; Region: DivIC; cl11433
483179003075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179003076	S-adenosylmethionine binding site [chemical binding]; other site
483179003077	enolase; Provisional; Region: eno; PRK00077
483179003078	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
483179003079	dimer interface [polypeptide binding]; other site
483179003080	metal binding site [ion binding]; metal-binding site
483179003081	substrate binding pocket [chemical binding]; other site
483179003082	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
483179003083	NeuB family; Region: NeuB; cl00496
483179003084	CTP synthetase; Validated; Region: pyrG; PRK05380
483179003085	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
483179003086	Catalytic site [active]
483179003087	active site
483179003088	UTP binding site [chemical binding]; other site
483179003089	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
483179003090	active site
483179003091	putative oxyanion hole; other site
483179003092	catalytic triad [active]
483179003093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
483179003094	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179003095	Preprotein translocase SecG subunit; Region: SecG; cl09123
483179003096	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
483179003097	substrate binding site [chemical binding]; other site
483179003098	dimer interface [polypeptide binding]; other site
483179003099	catalytic triad [active]
483179003100	SurA N-terminal domain; Region: SurA_N_3; cl07813
483179003101	PPIC-type PPIASE domain; Region: Rotamase; cl08278
483179003102	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
483179003103	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
483179003104	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
483179003105	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
483179003106	active site
483179003107	ribulose/triose binding site [chemical binding]; other site
483179003108	phosphate binding site [ion binding]; other site
483179003109	substrate (anthranilate) binding pocket [chemical binding]; other site
483179003110	product (indole) binding pocket [chemical binding]; other site
483179003111	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
483179003112	trimer interface [polypeptide binding]; other site
483179003113	dimer interface [polypeptide binding]; other site
483179003114	putative active site [active]
483179003115	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
483179003116	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
483179003117	dimer interface [polypeptide binding]; other site
483179003118	putative functional site; other site
483179003119	putative MPT binding site; other site
483179003120	LexA repressor; Validated; Region: PRK00215
483179003121	Helix-turn-helix domains; Region: HTH; cl00088
483179003122	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
483179003123	Catalytic site [active]
483179003124	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
483179003125	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
483179003126	Competence protein; Region: Competence; cl00471
483179003127	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
483179003128	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
483179003129	active site
483179003130	HIGH motif; other site
483179003131	nucleotide binding site [chemical binding]; other site
483179003132	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
483179003133	active site
483179003134	KMSKS motif; other site
483179003135	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
483179003136	dimer interface [polypeptide binding]; other site
483179003137	Citrate synthase; Region: Citrate_synt; pfam00285
483179003138	active site
483179003139	citrylCoA binding site [chemical binding]; other site
483179003140	NADH binding [chemical binding]; other site
483179003141	cationic pore residues; other site
483179003142	oxalacetate/citrate binding site [chemical binding]; other site
483179003143	coenzyme A binding site [chemical binding]; other site
483179003144	catalytic triad [active]
483179003145	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
483179003146	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
483179003147	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
483179003148	acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852
483179003149	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
483179003150	active site
483179003151	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
483179003152	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
483179003153	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
483179003154	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
483179003155	trimer interface [polypeptide binding]; other site
483179003156	active site
483179003157	UDP-GlcNAc binding site [chemical binding]; other site
483179003158	lipid binding site [chemical binding]; lipid-binding site
483179003159	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
483179003160	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
483179003161	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
483179003162	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
483179003163	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
483179003164	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
483179003165	Surface antigen; Region: Bac_surface_Ag; cl03097
483179003166	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
483179003167	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
483179003168	active site
483179003169	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
483179003170	protein binding site [polypeptide binding]; other site
483179003171	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
483179003172	putative substrate binding region [chemical binding]; other site
483179003173	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
483179003174	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
483179003175	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
483179003176	catalytic residue [active]
483179003177	putative FPP diphosphate  binding site; other site
483179003178	putative FPP binding hydrophobic cleft; other site
483179003179	dimer interface [polypeptide binding]; other site
483179003180	putative IPP diphosphate binding site; other site
483179003181	ribosome recycling factor; Reviewed; Region: frr; PRK00083
483179003182	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
483179003183	hinge region; other site
483179003184	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
483179003185	putative nucleotide binding site [chemical binding]; other site
483179003186	uridine monophosphate binding site [chemical binding]; other site
483179003187	homohexameric interface [polypeptide binding]; other site
483179003188	elongation factor Ts; Provisional; Region: tsf; PRK09377
483179003189	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
483179003190	Elongation factor TS; Region: EF_TS; pfam00889
483179003191	Elongation factor TS; Region: EF_TS; pfam00889
483179003192	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
483179003193	rRNA interaction site [nucleotide binding]; other site
483179003194	S8 interaction site; other site
483179003195	putative laminin-1 binding site; other site
483179003196	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
483179003197	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
483179003198	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
483179003199	homotrimer interaction site [polypeptide binding]; other site
483179003200	putative active site [active]
483179003201	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
483179003202	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
483179003203	putative active site [active]
483179003204	catalytic site [active]
483179003205	putative metal binding site [ion binding]; other site
483179003206	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179003207	Protein of unknown function, DUF482; Region: DUF482; pfam04339
483179003208	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
483179003209	HIT family signature motif; other site
483179003210	catalytic residue [active]
483179003211	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
483179003212	Clp amino terminal domain; Region: Clp_N; pfam02861
483179003213	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179003214	Walker A motif; other site
483179003215	ATP binding site [chemical binding]; other site
483179003216	Walker B motif; other site
483179003217	arginine finger; other site
483179003218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179003219	Walker A motif; other site
483179003220	ATP binding site [chemical binding]; other site
483179003221	Walker B motif; other site
483179003222	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
483179003223	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
483179003224	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
483179003225	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179003226	Sporulation related domain; Region: SPOR; cl10051
483179003227	Protein of unknown function (DUF1489); Region: DUF1489; cl11570
483179003228	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
483179003229	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
483179003230	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
483179003231	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
483179003232	putative active site [active]
483179003233	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
483179003234	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
483179003235	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
483179003236	DNA binding residues [nucleotide binding]
483179003237	putative dimer interface [polypeptide binding]; other site
483179003238	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
483179003239	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
483179003240	Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561
483179003241	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
483179003242	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
483179003243	non-specific DNA binding site [nucleotide binding]; other site
483179003244	salt bridge; other site
483179003245	sequence-specific DNA binding site [nucleotide binding]; other site
483179003246	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
483179003247	Domain of unknown function (DUF955); Region: DUF955; cl01076
483179003248	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
483179003249	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
483179003250	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
483179003251	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
483179003252	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179003253	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
483179003254	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
483179003255	carboxyltransferase (CT) interaction site; other site
483179003256	biotinylation site [posttranslational modification]; other site
483179003257	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
483179003258	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
483179003259	active site
483179003260	substrate binding site [chemical binding]; other site
483179003261	coenzyme B12 binding site [chemical binding]; other site
483179003262	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
483179003263	B12 binding site [chemical binding]; other site
483179003264	cobalt ligand [ion binding]; other site
483179003265	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
483179003266	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
483179003267	NMT1-like family; Region: NMT1_2; cl15260
483179003268	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
483179003269	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
483179003270	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
483179003271	intracellular protease, PfpI family; Region: PfpI; TIGR01382
483179003272	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
483179003273	conserved cys residue [active]
483179003274	Ribbon-helix-helix domain; Region: RHH_4; cl01775
483179003275	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
483179003276	alkaline phosphatase; Provisional; Region: PRK10518
483179003277	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
483179003278	dimer interface [polypeptide binding]; other site
483179003279	active site
483179003280	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
483179003281	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
483179003282	motif 1; other site
483179003283	active site
483179003284	motif 2; other site
483179003285	motif 3; other site
483179003286	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
483179003287	recombinase A; Provisional; Region: recA; PRK09354
483179003288	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
483179003289	hexamer interface [polypeptide binding]; other site
483179003290	Walker A motif; other site
483179003291	ATP binding site [chemical binding]; other site
483179003292	Walker B motif; other site
483179003293	putative outer membrane lipoprotein; Provisional; Region: PRK10510
483179003294	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
483179003295	ligand binding site [chemical binding]; other site
483179003296	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
483179003297	N-acetyl-D-glucosamine binding site [chemical binding]; other site
483179003298	catalytic residue [active]
483179003299	recombination factor protein RarA; Reviewed; Region: PRK13342
483179003300	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179003301	Walker A motif; other site
483179003302	ATP binding site [chemical binding]; other site
483179003303	Walker B motif; other site
483179003304	arginine finger; other site
483179003305	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
483179003306	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
483179003307	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
483179003308	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
483179003309	protein binding site [polypeptide binding]; other site
483179003310	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
483179003311	protein binding site [polypeptide binding]; other site
483179003312	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
483179003313	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
483179003314	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
483179003315	alphaNTD homodimer interface [polypeptide binding]; other site
483179003316	alphaNTD - beta interaction site [polypeptide binding]; other site
483179003317	alphaNTD - beta' interaction site [polypeptide binding]; other site
483179003318	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
483179003319	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
483179003320	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
483179003321	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
483179003322	adenylate kinase; Reviewed; Region: adk; PRK00279
483179003323	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
483179003324	AMP-binding site [chemical binding]; other site
483179003325	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
483179003326	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
483179003327	SecY translocase; Region: SecY; pfam00344
483179003328	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
483179003329	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
483179003330	23S rRNA binding site [nucleotide binding]; other site
483179003331	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
483179003332	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
483179003333	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
483179003334	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
483179003335	5S rRNA interface [nucleotide binding]; other site
483179003336	23S rRNA interface [nucleotide binding]; other site
483179003337	L5 interface [polypeptide binding]; other site
483179003338	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
483179003339	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
483179003340	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
483179003341	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
483179003342	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
483179003343	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
483179003344	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
483179003345	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
483179003346	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
483179003347	KOW motif; Region: KOW; cl00354
483179003348	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
483179003349	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
483179003350	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
483179003351	23S rRNA interface [nucleotide binding]; other site
483179003352	putative translocon interaction site; other site
483179003353	signal recognition particle (SRP54) interaction site; other site
483179003354	L23 interface [polypeptide binding]; other site
483179003355	trigger factor interaction site; other site
483179003356	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
483179003357	23S rRNA interface [nucleotide binding]; other site
483179003358	5S rRNA interface [nucleotide binding]; other site
483179003359	putative antibiotic binding site [chemical binding]; other site
483179003360	L25 interface [polypeptide binding]; other site
483179003361	L27 interface [polypeptide binding]; other site
483179003362	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
483179003363	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
483179003364	G-X-X-G motif; other site
483179003365	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
483179003366	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
483179003367	putative translocon binding site; other site
483179003368	protein-rRNA interface [nucleotide binding]; other site
483179003369	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
483179003370	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
483179003371	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
483179003372	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
483179003373	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
483179003374	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
483179003375	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
483179003376	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
483179003377	elongation factor Tu; Reviewed; Region: PRK00049
483179003378	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
483179003379	G1 box; other site
483179003380	GEF interaction site [polypeptide binding]; other site
483179003381	GTP/Mg2+ binding site [chemical binding]; other site
483179003382	Switch I region; other site
483179003383	G2 box; other site
483179003384	G3 box; other site
483179003385	Switch II region; other site
483179003386	G4 box; other site
483179003387	G5 box; other site
483179003388	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
483179003389	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
483179003390	Antibiotic Binding Site [chemical binding]; other site
483179003391	elongation factor G; Reviewed; Region: PRK00007
483179003392	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
483179003393	G1 box; other site
483179003394	putative GEF interaction site [polypeptide binding]; other site
483179003395	GTP/Mg2+ binding site [chemical binding]; other site
483179003396	Switch I region; other site
483179003397	G2 box; other site
483179003398	G3 box; other site
483179003399	Switch II region; other site
483179003400	G4 box; other site
483179003401	G5 box; other site
483179003402	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
483179003403	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
483179003404	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
483179003405	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
483179003406	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
483179003407	S17 interaction site [polypeptide binding]; other site
483179003408	S8 interaction site; other site
483179003409	16S rRNA interaction site [nucleotide binding]; other site
483179003410	streptomycin interaction site [chemical binding]; other site
483179003411	23S rRNA interaction site [nucleotide binding]; other site
483179003412	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
483179003413	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
483179003414	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
483179003415	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
483179003416	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
483179003417	DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388
483179003418	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
483179003419	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
483179003420	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
483179003421	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
483179003422	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
483179003423	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
483179003424	DNA binding site [nucleotide binding]
483179003425	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
483179003426	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
483179003427	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
483179003428	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
483179003429	RPB11 interaction site [polypeptide binding]; other site
483179003430	RPB12 interaction site [polypeptide binding]; other site
483179003431	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
483179003432	RPB1 interaction site [polypeptide binding]; other site
483179003433	RPB11 interaction site [polypeptide binding]; other site
483179003434	RPB10 interaction site [polypeptide binding]; other site
483179003435	RPB3 interaction site [polypeptide binding]; other site
483179003436	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
483179003437	L11 interface [polypeptide binding]; other site
483179003438	putative EF-Tu interaction site [polypeptide binding]; other site
483179003439	putative EF-G interaction site [polypeptide binding]; other site
483179003440	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
483179003441	23S rRNA interface [nucleotide binding]; other site
483179003442	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
483179003443	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
483179003444	mRNA/rRNA interface [nucleotide binding]; other site
483179003445	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
483179003446	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
483179003447	23S rRNA interface [nucleotide binding]; other site
483179003448	L7/L12 interface [polypeptide binding]; other site
483179003449	putative thiostrepton binding site; other site
483179003450	L25 interface [polypeptide binding]; other site
483179003451	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
483179003452	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
483179003453	putative homodimer interface [polypeptide binding]; other site
483179003454	KOW motif; Region: KOW; cl00354
483179003455	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
483179003456	elongation factor Tu; Reviewed; Region: PRK00049
483179003457	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
483179003458	G1 box; other site
483179003459	GEF interaction site [polypeptide binding]; other site
483179003460	GTP/Mg2+ binding site [chemical binding]; other site
483179003461	Switch I region; other site
483179003462	G2 box; other site
483179003463	G3 box; other site
483179003464	Switch II region; other site
483179003465	G4 box; other site
483179003466	G5 box; other site
483179003467	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
483179003468	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
483179003469	Antibiotic Binding Site [chemical binding]; other site
483179003470	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
483179003471	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
483179003472	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
483179003473	Rhomboid family; Region: Rhomboid; cl11446
483179003474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
483179003475	PAS domain; Region: PAS_5; pfam07310
483179003476	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
483179003477	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
483179003478	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
483179003479	trimer interface [polypeptide binding]; other site
483179003480	putative metal binding site [ion binding]; other site
483179003481	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
483179003482	serine acetyltransferase; Provisional; Region: cysE; PRK11132
483179003483	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
483179003484	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
483179003485	trimer interface [polypeptide binding]; other site
483179003486	active site
483179003487	substrate binding site [chemical binding]; other site
483179003488	CoA binding site [chemical binding]; other site
483179003489	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179003490	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
483179003491	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
483179003492	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
483179003493	DNA-binding site [nucleotide binding]; DNA binding site
483179003494	RNA-binding motif; other site
483179003495	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
483179003496	DNA-binding site [nucleotide binding]; DNA binding site
483179003497	RNA-binding motif; other site
483179003498	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179003499	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
483179003500	dimer interface [polypeptide binding]; other site
483179003501	active site
483179003502	metal binding site [ion binding]; metal-binding site
483179003503	glutathione binding site [chemical binding]; other site
483179003504	Tim44-like domain; Region: Tim44; cl09208
483179003505	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
483179003506	DHH family; Region: DHH; pfam01368
483179003507	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
483179003508	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
483179003509	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179003510	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
483179003511	putative active site [active]
483179003512	homoserine dehydrogenase; Provisional; Region: PRK06349
483179003513	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179003514	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
483179003515	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
483179003516	aminotransferase; Validated; Region: PRK09148
483179003517	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
483179003518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179003519	homodimer interface [polypeptide binding]; other site
483179003520	catalytic residue [active]
483179003521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
483179003522	Peptidase M15; Region: Peptidase_M15_3; cl01194
483179003523	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
483179003524	Sugar fermentation stimulation protein; Region: SfsA; cl00647
483179003525	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
483179003526	active site
483179003527	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
483179003528	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
483179003529	MPN+ (JAMM) motif; other site
483179003530	Zinc-binding site [ion binding]; other site
483179003531	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179003532	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
483179003533	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179003534	precorrin-3B synthase; Region: CobG; TIGR02435
483179003535	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
483179003536	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
483179003537	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
483179003538	Precorrin-8X methylmutase; Region: CbiC; pfam02570
483179003539	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
483179003540	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
483179003541	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
483179003542	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
483179003543	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
483179003544	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
483179003545	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
483179003546	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
483179003547	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
483179003548	Flavin Reductases; Region: FlaRed; cl00801
483179003549	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
483179003550	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
483179003551	ligand binding site [chemical binding]; other site
483179003552	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
483179003553	CobD/Cbib protein; Region: CobD_Cbib; cl00561
483179003554	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
483179003555	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
483179003556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179003557	homodimer interface [polypeptide binding]; other site
483179003558	catalytic residue [active]
483179003559	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
483179003560	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
483179003561	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
483179003562	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
483179003563	CbiD; Region: CbiD; cl00828
483179003564	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
483179003565	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
483179003566	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
483179003567	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
483179003568	tellurium resistance terB-like protein; Region: terB_like; cd07177
483179003569	metal binding site [ion binding]; metal-binding site
483179003570	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
483179003571	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
483179003572	EamA-like transporter family; Region: EamA; cl01037
483179003573	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
483179003574	homodimer interface [polypeptide binding]; other site
483179003575	Walker A motif; other site
483179003576	ATP binding site [chemical binding]; other site
483179003577	hydroxycobalamin binding site [chemical binding]; other site
483179003578	Walker B motif; other site
483179003579	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
483179003580	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
483179003581	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
483179003582	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
483179003583	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179003584	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
483179003585	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
483179003586	homotrimer interface [polypeptide binding]; other site
483179003587	Walker A motif; other site
483179003588	GTP binding site [chemical binding]; other site
483179003589	Walker B motif; other site
483179003590	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
483179003591	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
483179003592	cobyric acid synthase; Provisional; Region: PRK00784
483179003593	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179003594	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179003595	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
483179003596	catalytic triad [active]
483179003597	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
483179003598	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179003599	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
483179003600	Entericidin EcnA/B family; Region: Entericidin; cl02322
483179003601	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
483179003602	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
483179003603	conserved cys residue [active]
483179003604	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179003605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179003606	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023
483179003607	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
483179003608	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
483179003609	Protein export membrane protein; Region: SecD_SecF; cl14618
483179003610	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
483179003611	Protein export membrane protein; Region: SecD_SecF; cl14618
483179003612	putative cation:proton antiport protein; Provisional; Region: PRK10669
483179003613	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
483179003614	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179003615	Predicted integral membrane protein [Function unknown]; Region: COG0392
483179003616	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
483179003617	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179003618	sulfate transport protein; Provisional; Region: cysT; CHL00187
483179003619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179003620	dimer interface [polypeptide binding]; other site
483179003621	conserved gate region; other site
483179003622	putative PBP binding loops; other site
483179003623	ABC-ATPase subunit interface; other site
483179003624	sulfate transport protein; Provisional; Region: cysT; CHL00187
483179003625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179003626	dimer interface [polypeptide binding]; other site
483179003627	conserved gate region; other site
483179003628	putative PBP binding loops; other site
483179003629	ABC-ATPase subunit interface; other site
483179003630	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179003631	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
483179003632	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
483179003633	Integral membrane protein TerC family; Region: TerC; cl10468
483179003634	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
483179003635	Transporter associated domain; Region: CorC_HlyC; cl08393
483179003636	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
483179003637	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302
483179003638	EF-hand domain pair; Region: EF_hand_5; pfam13499
483179003639	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
483179003640	short chain dehydrogenase; Provisional; Region: PRK06198
483179003641	classical (c) SDRs; Region: SDR_c; cd05233
483179003642	NAD(P) binding site [chemical binding]; other site
483179003643	active site
483179003644	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
483179003645	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
483179003646	Walker A/P-loop; other site
483179003647	ATP binding site [chemical binding]; other site
483179003648	Q-loop/lid; other site
483179003649	ABC transporter signature motif; other site
483179003650	Walker B; other site
483179003651	D-loop; other site
483179003652	H-loop/switch region; other site
483179003653	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179003654	TM-ABC transporter signature motif; other site
483179003655	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
483179003656	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
483179003657	putative ligand binding site [chemical binding]; other site
483179003658	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179003659	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179003660	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
483179003661	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
483179003662	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
483179003663	Walker A/P-loop; other site
483179003664	ATP binding site [chemical binding]; other site
483179003665	Q-loop/lid; other site
483179003666	ABC transporter signature motif; other site
483179003667	Walker B; other site
483179003668	D-loop; other site
483179003669	H-loop/switch region; other site
483179003670	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
483179003671	ABC-ATPase subunit  interface; other site
483179003672	dimer interface [polypeptide binding]; other site
483179003673	putative PBP binding regions; other site
483179003674	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
483179003675	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
483179003676	intersubunit interface [polypeptide binding]; other site
483179003677	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
483179003678	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
483179003679	N-terminal plug; other site
483179003680	ligand-binding site [chemical binding]; other site
483179003681	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
483179003682	ABC-2 type transporter; Region: ABC2_membrane; cl11417
483179003683	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179003684	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179003685	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
483179003686	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
483179003687	alpha-gamma subunit interface [polypeptide binding]; other site
483179003688	beta-gamma subunit interface [polypeptide binding]; other site
483179003689	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
483179003690	alpha-beta subunit interface [polypeptide binding]; other site
483179003691	urease subunit alpha; Reviewed; Region: ureC; PRK13309
483179003692	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
483179003693	subunit interactions [polypeptide binding]; other site
483179003694	active site
483179003695	flap region; other site
483179003696	urease accessory protein UreE; Provisional; Region: ureE; PRK14711
483179003697	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
483179003698	dimer interface [polypeptide binding]; other site
483179003699	catalytic residues [active]
483179003700	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
483179003701	UreF; Region: UreF; pfam01730
483179003702	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179003703	UreD urease accessory protein; Region: UreD; cl00530
483179003704	Urea transporter; Region: UT; cl01829
483179003705	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
483179003706	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
483179003707	Cobalt transport protein; Region: CbiQ; cl00463
483179003708	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
483179003709	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
483179003710	Walker A/P-loop; other site
483179003711	ATP binding site [chemical binding]; other site
483179003712	Q-loop/lid; other site
483179003713	ABC transporter signature motif; other site
483179003714	Walker B; other site
483179003715	D-loop; other site
483179003716	H-loop/switch region; other site
483179003717	CrcB-like protein; Region: CRCB; cl09114
483179003718	Domain of unknown function DUF302; Region: DUF302; cl01364
483179003719	CrcB-like protein; Region: CRCB; cl09114
483179003720	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
483179003721	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
483179003722	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
483179003723	BA14K-like protein; Region: BA14K; pfam07886
483179003724	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
483179003725	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
483179003726	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179003727	homodimer interface [polypeptide binding]; other site
483179003728	catalytic residue [active]
483179003729	ketol-acid reductoisomerase; Provisional; Region: PRK05479
483179003730	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179003731	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
483179003732	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
483179003733	Helix-turn-helix domains; Region: HTH; cl00088
483179003734	K+ potassium transporter; Region: K_trans; cl15781
483179003735	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cl00541
483179003736	active site
483179003737	hydrophilic channel; other site
483179003738	dimerization interface [polypeptide binding]; other site
483179003739	catalytic residues [active]
483179003740	active site lid [active]
483179003741	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
483179003742	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179003743	Family description; Region: UvrD_C_2; cl15862
483179003744	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
483179003745	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
483179003746	putative valine binding site [chemical binding]; other site
483179003747	dimer interface [polypeptide binding]; other site
483179003748	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
483179003749	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
483179003750	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
483179003751	PYR/PP interface [polypeptide binding]; other site
483179003752	dimer interface [polypeptide binding]; other site
483179003753	TPP binding site [chemical binding]; other site
483179003754	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
483179003755	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
483179003756	TPP-binding site [chemical binding]; other site
483179003757	dimer interface [polypeptide binding]; other site
483179003758	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
483179003759	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179003760	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
483179003761	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179003762	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179003763	motif II; other site
483179003764	HI0933-like protein; Region: HI0933_like; pfam03486
483179003765	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179003766	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
483179003767	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
483179003768	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
483179003769	protein binding site [polypeptide binding]; other site
483179003770	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
483179003771	protein binding site [polypeptide binding]; other site
483179003772	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
483179003773	FtsH protease regulator HflC; Provisional; Region: PRK11029
483179003774	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
483179003775	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
483179003776	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
483179003777	HflK protein; Region: hflK; TIGR01933
483179003778	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
483179003779	folate binding site [chemical binding]; other site
483179003780	NADP+ binding site [chemical binding]; other site
483179003781	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
483179003782	dimerization interface [polypeptide binding]; other site
483179003783	active site
483179003784	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
483179003785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179003786	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
483179003787	putative substrate translocation pore; other site
483179003788	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
483179003789	Helix-turn-helix domains; Region: HTH; cl00088
483179003790	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
483179003791	Stringent starvation protein B; Region: SspB; cl01120
483179003792	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
483179003793	Ribbon-helix-helix domain; Region: RHH_4; cl01775
483179003794	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
483179003795	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
483179003796	AsmA-like C-terminal region; Region: AsmA_2; cl15864
483179003797	D-lactate dehydrogenase [cytochrome]; Region: PLN02805
483179003798	FAD binding domain; Region: FAD_binding_4; pfam01565
483179003799	Domain of unknown function (DUF336); Region: DUF336; cl01249
483179003800	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
483179003801	active site
483179003802	ATP binding site [chemical binding]; other site
483179003803	acetate-CoA ligase; Region: PLN02654
483179003804	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
483179003805	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179003806	Family description; Region: UvrD_C_2; cl15862
483179003807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
483179003808	CreA protein; Region: CreA; pfam05981
483179003809	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
483179003810	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
483179003811	trimer interface [polypeptide binding]; other site
483179003812	active site
483179003813	substrate binding site [chemical binding]; other site
483179003814	CoA binding site [chemical binding]; other site
483179003815	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
483179003816	Cu(I) binding site [ion binding]; other site
483179003817	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
483179003818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179003819	S-adenosylmethionine binding site [chemical binding]; other site
483179003820	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
483179003821	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
483179003822	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
483179003823	active site
483179003824	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
483179003825	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
483179003826	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
483179003827	nucleotide binding pocket [chemical binding]; other site
483179003828	K-X-D-G motif; other site
483179003829	catalytic site [active]
483179003830	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
483179003831	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
483179003832	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
483179003833	Dimer interface [polypeptide binding]; other site
483179003834	BRCT sequence motif; other site
483179003835	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
483179003836	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
483179003837	Walker A/P-loop; other site
483179003838	ATP binding site [chemical binding]; other site
483179003839	Q-loop/lid; other site
483179003840	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
483179003841	ABC transporter signature motif; other site
483179003842	Walker B; other site
483179003843	D-loop; other site
483179003844	H-loop/switch region; other site
483179003845	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
483179003846	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
483179003847	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
483179003848	cell division protein FtsZ; Validated; Region: PRK09330
483179003849	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
483179003850	nucleotide binding site [chemical binding]; other site
483179003851	SulA interaction site; other site
483179003852	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
483179003853	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
483179003854	Cell division protein FtsA; Region: FtsA; cl11496
483179003855	Cell division protein FtsA; Region: FtsA; cl11496
483179003856	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
483179003857	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
483179003858	Cell division protein FtsQ; Region: FtsQ; pfam03799
483179003859	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
483179003860	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
483179003861	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179003862	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
483179003863	FAD binding domain; Region: FAD_binding_4; pfam01565
483179003864	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
483179003865	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
483179003866	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
483179003867	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
483179003868	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
483179003869	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
483179003870	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
483179003871	active site
483179003872	homodimer interface [polypeptide binding]; other site
483179003873	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
483179003874	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
483179003875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179003876	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
483179003877	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
483179003878	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
483179003879	Mg++ binding site [ion binding]; other site
483179003880	putative catalytic motif [active]
483179003881	putative substrate binding site [chemical binding]; other site
483179003882	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
483179003883	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
483179003884	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
483179003885	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
483179003886	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
483179003887	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
483179003888	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
483179003889	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
483179003890	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
483179003891	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
483179003892	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179003893	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
483179003894	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
483179003895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179003896	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
483179003897	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
483179003898	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
483179003899	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
483179003900	N-acetyl-D-glucosamine binding site [chemical binding]; other site
483179003901	catalytic residue [active]
483179003902	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
483179003903	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
483179003904	amidase catalytic site [active]
483179003905	Zn binding residues [ion binding]; other site
483179003906	substrate binding site [chemical binding]; other site
483179003907	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
483179003908	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
483179003909	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
483179003910	putative metal binding site [ion binding]; other site
483179003911	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
483179003912	HSP70 interaction site [polypeptide binding]; other site
483179003913	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
483179003914	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
483179003915	active site
483179003916	Membrane transport protein; Region: Mem_trans; cl09117
483179003917	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
483179003918	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
483179003919	FAD binding site [chemical binding]; other site
483179003920	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179003921	dimerization interface [polypeptide binding]; other site
483179003922	putative DNA binding site [nucleotide binding]; other site
483179003923	putative Zn2+ binding site [ion binding]; other site
483179003924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179003925	S-adenosylmethionine binding site [chemical binding]; other site
483179003926	Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373
483179003927	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
483179003928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179003929	putative substrate translocation pore; other site
483179003930	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
483179003931	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179003932	S-adenosylmethionine binding site [chemical binding]; other site
483179003933	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
483179003934	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179003935	Walker A/P-loop; other site
483179003936	ATP binding site [chemical binding]; other site
483179003937	Q-loop/lid; other site
483179003938	ABC transporter signature motif; other site
483179003939	Walker B; other site
483179003940	D-loop; other site
483179003941	H-loop/switch region; other site
483179003942	ABC transporter; Region: ABC_tran_2; pfam12848
483179003943	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
483179003944	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
483179003945	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179003946	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179003947	Cupin domain; Region: Cupin_2; cl09118
483179003948	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
483179003949	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
483179003950	[2Fe-2S] cluster binding site [ion binding]; other site
483179003951	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
483179003952	putative alpha subunit interface [polypeptide binding]; other site
483179003953	putative active site [active]
483179003954	putative substrate binding site [chemical binding]; other site
483179003955	Fe binding site [ion binding]; other site
483179003956	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
483179003957	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
483179003958	FAD binding pocket [chemical binding]; other site
483179003959	FAD binding motif [chemical binding]; other site
483179003960	phosphate binding motif [ion binding]; other site
483179003961	beta-alpha-beta structure motif; other site
483179003962	NAD binding pocket [chemical binding]; other site
483179003963	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
483179003964	catalytic loop [active]
483179003965	iron binding site [ion binding]; other site
483179003966	PhnA protein; Region: PhnA; pfam03831
483179003967	Isochorismatase family; Region: Isochorismatase; pfam00857
483179003968	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
483179003969	catalytic triad [active]
483179003970	metal binding site [ion binding]; metal-binding site
483179003971	conserved cis-peptide bond; other site
483179003972	Integral membrane protein TerC family; Region: TerC; cl10468
483179003973	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
483179003974	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
483179003975	active site
483179003976	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
483179003977	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
483179003978	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
483179003979	active site
483179003980	catalytic residues [active]
483179003981	DNA binding site [nucleotide binding]
483179003982	Int/Topo IB signature motif; other site
483179003983	Protein of unknown function (DUF541); Region: SIMPL; cl01077
483179003984	Flagellin N-methylase; Region: FliB; cl00497
483179003985	Transcriptional activator HlyU; Region: HlyU; cl02273
483179003986	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
483179003987	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
483179003988	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
483179003989	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
483179003990	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
483179003991	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
483179003992	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
483179003993	DNA binding residues [nucleotide binding]
483179003994	DNA primase; Validated; Region: dnaG; PRK05667
483179003995	CHC2 zinc finger; Region: zf-CHC2; cl15369
483179003996	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
483179003997	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
483179003998	active site
483179003999	metal binding site [ion binding]; metal-binding site
483179004000	interdomain interaction site; other site
483179004001	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
483179004002	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
483179004003	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
483179004004	PhoU domain; Region: PhoU; pfam01895
483179004005	PhoU domain; Region: PhoU; pfam01895
483179004006	GatB domain; Region: GatB_Yqey; cl11497
483179004007	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
483179004008	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
483179004009	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
483179004010	catalytic site [active]
483179004011	subunit interface [polypeptide binding]; other site
483179004012	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
483179004013	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
483179004014	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
483179004015	LytTr DNA-binding domain; Region: LytTR; cl04498
483179004016	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
483179004017	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
483179004018	Invariant surface glycoprotein; Region: ISG65-75; cl15448
483179004019	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179004020	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
483179004021	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
483179004022	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179004023	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
483179004024	IMP binding site; other site
483179004025	dimer interface [polypeptide binding]; other site
483179004026	partial ornithine binding site; other site
483179004027	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
483179004028	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179004029	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
483179004030	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
483179004031	nudix motif; other site
483179004032	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
483179004033	DNA-binding site [nucleotide binding]; DNA binding site
483179004034	RNA-binding motif; other site
483179004035	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
483179004036	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
483179004037	putative C-terminal domain interface [polypeptide binding]; other site
483179004038	putative GSH binding site (G-site) [chemical binding]; other site
483179004039	putative dimer interface [polypeptide binding]; other site
483179004040	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
483179004041	N-terminal domain interface [polypeptide binding]; other site
483179004042	dimer interface [polypeptide binding]; other site
483179004043	substrate binding pocket (H-site) [chemical binding]; other site
483179004044	aspartate aminotransferase; Provisional; Region: PRK05764
483179004045	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
483179004046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179004047	homodimer interface [polypeptide binding]; other site
483179004048	catalytic residue [active]
483179004049	Transcriptional regulator [Transcription]; Region: LysR; COG0583
483179004050	Helix-turn-helix domains; Region: HTH; cl00088
483179004051	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
483179004052	putative effector binding pocket; other site
483179004053	dimerization interface [polypeptide binding]; other site
483179004054	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
483179004055	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179004056	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
483179004057	Cation transport protein; Region: TrkH; cl10514
483179004058	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
483179004059	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179004060	dimerization interface [polypeptide binding]; other site
483179004061	putative DNA binding site [nucleotide binding]; other site
483179004062	putative Zn2+ binding site [ion binding]; other site
483179004063	AsnC family; Region: AsnC_trans_reg; pfam01037
483179004064	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
483179004065	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
483179004066	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
483179004067	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
483179004068	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
483179004069	EamA-like transporter family; Region: EamA; cl01037
483179004070	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
483179004071	EamA-like transporter family; Region: EamA; cl01037
483179004072	Protein of unknown function, DUF486; Region: DUF486; cl01236
483179004073	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
483179004074	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
483179004075	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
483179004076	Bacterial SH3 domain; Region: SH3_3; cl02551
483179004077	excinuclease ABC subunit B; Provisional; Region: PRK05298
483179004078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
483179004079	ATP binding site [chemical binding]; other site
483179004080	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
483179004081	nucleotide binding region [chemical binding]; other site
483179004082	ATP-binding site [chemical binding]; other site
483179004083	Ultra-violet resistance protein B; Region: UvrB; pfam12344
483179004084	UvrB/uvrC motif; Region: UVR; pfam02151
483179004085	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
483179004086	DNA-binding site [nucleotide binding]; DNA binding site
483179004087	RNA-binding motif; other site
483179004088	BA14K-like protein; Region: BA14K; pfam07886
483179004089	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
483179004090	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
483179004091	Helix-turn-helix domains; Region: HTH; cl00088
483179004092	osmolarity response regulator; Provisional; Region: ompR; PRK09468
483179004093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179004094	active site
483179004095	phosphorylation site [posttranslational modification]
483179004096	intermolecular recognition site; other site
483179004097	dimerization interface [polypeptide binding]; other site
483179004098	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179004099	DNA binding site [nucleotide binding]
483179004100	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
483179004101	dimer interface [polypeptide binding]; other site
483179004102	phosphorylation site [posttranslational modification]
483179004103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179004104	ATP binding site [chemical binding]; other site
483179004105	Mg2+ binding site [ion binding]; other site
483179004106	G-X-G motif; other site
483179004107	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
483179004108	dimer interface [polypeptide binding]; other site
483179004109	putative tRNA-binding site [nucleotide binding]; other site
483179004110	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
483179004111	Membrane fusogenic activity; Region: BMFP; cl01115
483179004112	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
483179004113	Uncharacterized conserved protein [Function unknown]; Region: COG1565
483179004114	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
483179004115	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
483179004116	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
483179004117	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
483179004118	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
483179004119	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
483179004120	active site
483179004121	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
483179004122	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
483179004123	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
483179004124	active site
483179004125	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
483179004126	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
483179004127	5S rRNA interface [nucleotide binding]; other site
483179004128	CTC domain interface [polypeptide binding]; other site
483179004129	L16 interface [polypeptide binding]; other site
483179004130	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
483179004131	putative active site [active]
483179004132	catalytic residue [active]
483179004133	GTP-binding protein YchF; Reviewed; Region: PRK09601
483179004134	YchF GTPase; Region: YchF; cd01900
483179004135	G1 box; other site
483179004136	GTP/Mg2+ binding site [chemical binding]; other site
483179004137	Switch I region; other site
483179004138	G2 box; other site
483179004139	Switch II region; other site
483179004140	G3 box; other site
483179004141	G4 box; other site
483179004142	G5 box; other site
483179004143	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
483179004144	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
483179004145	putative active site [active]
483179004146	putative catalytic site [active]
483179004147	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
483179004148	putative active site [active]
483179004149	putative catalytic site [active]
483179004150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
483179004151	active site
483179004152	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
483179004153	cytochrome b; Provisional; Region: CYTB; MTH00191
483179004154	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
483179004155	Qi binding site; other site
483179004156	intrachain domain interface; other site
483179004157	interchain domain interface [polypeptide binding]; other site
483179004158	heme bH binding site [chemical binding]; other site
483179004159	heme bL binding site [chemical binding]; other site
483179004160	Qo binding site; other site
483179004161	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
483179004162	interchain domain interface [polypeptide binding]; other site
483179004163	intrachain domain interface; other site
483179004164	Qi binding site; other site
483179004165	Qo binding site; other site
483179004166	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
483179004167	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
483179004168	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
483179004169	[2Fe-2S] cluster binding site [ion binding]; other site
483179004170	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
483179004171	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179004172	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179004173	Walker A/P-loop; other site
483179004174	ATP binding site [chemical binding]; other site
483179004175	Q-loop/lid; other site
483179004176	ABC transporter signature motif; other site
483179004177	Walker B; other site
483179004178	D-loop; other site
483179004179	H-loop/switch region; other site
483179004180	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
483179004181	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179004182	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
483179004183	Walker A/P-loop; other site
483179004184	ATP binding site [chemical binding]; other site
483179004185	Q-loop/lid; other site
483179004186	ABC transporter signature motif; other site
483179004187	Walker B; other site
483179004188	D-loop; other site
483179004189	H-loop/switch region; other site
483179004190	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
483179004191	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
483179004192	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
483179004193	Predicted acetyltransferase [General function prediction only]; Region: COG3153
483179004194	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
483179004195	Coenzyme A binding pocket [chemical binding]; other site
483179004196	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
483179004197	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
483179004198	active site
483179004199	NTP binding site [chemical binding]; other site
483179004200	metal binding triad [ion binding]; metal-binding site
483179004201	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
483179004202	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
483179004203	putative active site [active]
483179004204	putative CoA binding site [chemical binding]; other site
483179004205	nudix motif; other site
483179004206	metal binding site [ion binding]; metal-binding site
483179004207	Protein of unknown function (DUF1285); Region: DUF1285; cl01571
483179004208	MoxR-like ATPases [General function prediction only]; Region: COG0714
483179004209	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179004210	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
483179004211	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
483179004212	Aerotolerance regulator N-terminal; Region: BatA; cl06567
483179004213	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
483179004214	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
483179004215	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
483179004216	Predicted acetyltransferase [General function prediction only]; Region: COG3153
483179004217	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
483179004218	Coenzyme A binding pocket [chemical binding]; other site
483179004219	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
483179004220	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
483179004221	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
483179004222	putative dimer interface [polypeptide binding]; other site
483179004223	N-terminal domain interface [polypeptide binding]; other site
483179004224	putative substrate binding pocket (H-site) [chemical binding]; other site
483179004225	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179004226	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
483179004227	nudix motif; other site
483179004228	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
483179004229	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
483179004230	active site
483179004231	metal binding site [ion binding]; metal-binding site
483179004232	2-isopropylmalate synthase; Validated; Region: PRK03739
483179004233	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
483179004234	active site
483179004235	catalytic residues [active]
483179004236	metal binding site [ion binding]; metal-binding site
483179004237	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
483179004238	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
483179004239	Cation efflux family; Region: Cation_efflux; cl00316
483179004240	anthranilate synthase; Provisional; Region: PRK13566
483179004241	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
483179004242	chorismate binding enzyme; Region: Chorismate_bind; cl10555
483179004243	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
483179004244	glutamine binding [chemical binding]; other site
483179004245	catalytic triad [active]
483179004246	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
483179004247	Helix-turn-helix domains; Region: HTH; cl00088
483179004248	AsnC family; Region: AsnC_trans_reg; pfam01037
483179004249	Transcriptional regulators [Transcription]; Region: MarR; COG1846
483179004250	Helix-turn-helix domains; Region: HTH; cl00088
483179004251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179004252	putative substrate translocation pore; other site
483179004253	Major Facilitator Superfamily; Region: MFS_1; pfam07690
483179004254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179004255	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978
483179004256	NMT1-like family; Region: NMT1_2; cl15260
483179004257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179004258	dimer interface [polypeptide binding]; other site
483179004259	conserved gate region; other site
483179004260	putative PBP binding loops; other site
483179004261	ABC-ATPase subunit interface; other site
483179004262	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
483179004263	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179004264	Walker A/P-loop; other site
483179004265	ATP binding site [chemical binding]; other site
483179004266	Q-loop/lid; other site
483179004267	ABC transporter signature motif; other site
483179004268	Walker B; other site
483179004269	D-loop; other site
483179004270	H-loop/switch region; other site
483179004271	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179004272	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
483179004273	Walker A/P-loop; other site
483179004274	ATP binding site [chemical binding]; other site
483179004275	Q-loop/lid; other site
483179004276	ABC transporter signature motif; other site
483179004277	Walker B; other site
483179004278	D-loop; other site
483179004279	H-loop/switch region; other site
483179004280	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179004281	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179004282	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
483179004283	Walker A/P-loop; other site
483179004284	ATP binding site [chemical binding]; other site
483179004285	Q-loop/lid; other site
483179004286	ABC transporter signature motif; other site
483179004287	Walker B; other site
483179004288	D-loop; other site
483179004289	H-loop/switch region; other site
483179004290	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179004291	dipeptide transporter; Provisional; Region: PRK10913
483179004292	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
483179004293	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179004294	dimer interface [polypeptide binding]; other site
483179004295	conserved gate region; other site
483179004296	putative PBP binding loops; other site
483179004297	ABC-ATPase subunit interface; other site
483179004298	dipeptide transporter permease DppB; Provisional; Region: PRK10914
483179004299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179004300	dimer interface [polypeptide binding]; other site
483179004301	conserved gate region; other site
483179004302	putative PBP binding loops; other site
483179004303	ABC-ATPase subunit interface; other site
483179004304	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
483179004305	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179004306	dimerization interface [polypeptide binding]; other site
483179004307	putative DNA binding site [nucleotide binding]; other site
483179004308	putative Zn2+ binding site [ion binding]; other site
483179004309	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
483179004310	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
483179004311	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
483179004312	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
483179004313	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
483179004314	Ligand Binding Site [chemical binding]; other site
483179004315	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
483179004316	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179004317	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
483179004318	Protein of unknown function (DUF1134); Region: DUF1134; cl02235
483179004319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
483179004320	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
483179004321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179004322	active site
483179004323	phosphorylation site [posttranslational modification]
483179004324	intermolecular recognition site; other site
483179004325	dimerization interface [polypeptide binding]; other site
483179004326	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179004327	DNA binding site [nucleotide binding]
483179004328	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
483179004329	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
483179004330	inhibitor-cofactor binding pocket; inhibition site
483179004331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179004332	catalytic residue [active]
483179004333	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179004334	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179004335	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
483179004336	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
483179004337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
483179004338	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
483179004339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
483179004340	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
483179004341	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179004342	dimer interface [polypeptide binding]; other site
483179004343	phosphorylation site [posttranslational modification]
483179004344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179004345	ATP binding site [chemical binding]; other site
483179004346	Mg2+ binding site [ion binding]; other site
483179004347	G-X-G motif; other site
483179004348	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
483179004349	AsmA-like C-terminal region; Region: AsmA_2; cl15864
483179004350	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
483179004351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179004352	dimer interface [polypeptide binding]; other site
483179004353	conserved gate region; other site
483179004354	putative PBP binding loops; other site
483179004355	ABC-ATPase subunit interface; other site
483179004356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179004357	dimer interface [polypeptide binding]; other site
483179004358	conserved gate region; other site
483179004359	putative PBP binding loops; other site
483179004360	ABC-ATPase subunit interface; other site
483179004361	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
483179004362	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
483179004363	Walker A/P-loop; other site
483179004364	ATP binding site [chemical binding]; other site
483179004365	Q-loop/lid; other site
483179004366	ABC transporter signature motif; other site
483179004367	Walker B; other site
483179004368	D-loop; other site
483179004369	H-loop/switch region; other site
483179004370	TOBE domain; Region: TOBE_2; cl01440
483179004371	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
483179004372	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179004373	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
483179004374	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
483179004375	non-specific DNA binding site [nucleotide binding]; other site
483179004376	salt bridge; other site
483179004377	sequence-specific DNA binding site [nucleotide binding]; other site
483179004378	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
483179004379	Domain of unknown function (DUF955); Region: DUF955; cl01076
483179004380	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
483179004381	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
483179004382	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
483179004383	tetramer interface [polypeptide binding]; other site
483179004384	active site
483179004385	Mg2+/Mn2+ binding site [ion binding]; other site
483179004386	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
483179004387	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
483179004388	NAD binding site [chemical binding]; other site
483179004389	substrate binding site [chemical binding]; other site
483179004390	homotetramer interface [polypeptide binding]; other site
483179004391	homodimer interface [polypeptide binding]; other site
483179004392	active site
483179004393	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
483179004394	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
483179004395	NAD binding site [chemical binding]; other site
483179004396	substrate binding site [chemical binding]; other site
483179004397	homotetramer interface [polypeptide binding]; other site
483179004398	homodimer interface [polypeptide binding]; other site
483179004399	active site
483179004400	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
483179004401	MarC family integral membrane protein; Region: MarC; cl00919
483179004402	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
483179004403	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
483179004404	active site
483179004405	nucleophile elbow; other site
483179004406	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
483179004407	DAK2 domain; Region: Dak2; cl03685
483179004408	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
483179004409	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
483179004410	DNA binding residues [nucleotide binding]
483179004411	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
483179004412	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
483179004413	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
483179004414	DAK2 domain; Region: Dak2; cl03685
483179004415	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
483179004416	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
483179004417	short chain dehydrogenase; Provisional; Region: PRK06841
483179004418	classical (c) SDRs; Region: SDR_c; cd05233
483179004419	NAD(P) binding site [chemical binding]; other site
483179004420	active site
483179004421	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
483179004422	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
483179004423	putative ligand binding site [chemical binding]; other site
483179004424	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179004425	TM-ABC transporter signature motif; other site
483179004426	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
483179004427	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179004428	Walker A/P-loop; other site
483179004429	ATP binding site [chemical binding]; other site
483179004430	Q-loop/lid; other site
483179004431	ABC transporter signature motif; other site
483179004432	Walker B; other site
483179004433	D-loop; other site
483179004434	H-loop/switch region; other site
483179004435	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
483179004436	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
483179004437	Transcriptional regulator [Transcription]; Region: IclR; COG1414
483179004438	Helix-turn-helix domains; Region: HTH; cl00088
483179004439	Bacterial transcriptional regulator; Region: IclR; pfam01614
483179004440	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179004441	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
483179004442	tetramerization interface [polypeptide binding]; other site
483179004443	NAD(P) binding site [chemical binding]; other site
483179004444	catalytic residues [active]
483179004445	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
483179004446	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
483179004447	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
483179004448	active site
483179004449	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
483179004450	helix-hairpin-helix signature motif; other site
483179004451	substrate binding pocket [chemical binding]; other site
483179004452	active site
483179004453	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
483179004454	active site
483179004455	HIGH motif; other site
483179004456	nucleotide binding site [chemical binding]; other site
483179004457	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
483179004458	active site
483179004459	KMSKS motif; other site
483179004460	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
483179004461	active site
483179004462	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
483179004463	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179004464	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
483179004465	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
483179004466	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
483179004467	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
483179004468	DNA binding residues [nucleotide binding]
483179004469	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
483179004470	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
483179004471	RNA binding surface [nucleotide binding]; other site
483179004472	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
483179004473	active site
483179004474	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
483179004475	metal binding site 2 [ion binding]; metal-binding site
483179004476	putative DNA binding helix; other site
483179004477	metal binding site 1 [ion binding]; metal-binding site
483179004478	dimer interface [polypeptide binding]; other site
483179004479	structural Zn2+ binding site [ion binding]; other site
483179004480	PAS fold; Region: PAS_4; pfam08448
483179004481	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
483179004482	Histidine kinase; Region: HisKA_2; cl06527
483179004483	two-component response regulator; Provisional; Region: PRK09191
483179004484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179004485	active site
483179004486	phosphorylation site [posttranslational modification]
483179004487	intermolecular recognition site; other site
483179004488	dimerization interface [polypeptide binding]; other site
483179004489	RNA polymerase sigma factor; Provisional; Region: PRK12516
483179004490	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
483179004491	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
483179004492	DNA binding residues [nucleotide binding]
483179004493	CHASE3 domain; Region: CHASE3; cl05000
483179004494	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
483179004495	Histidine kinase; Region: HisKA_2; cl06527
483179004496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179004497	ATP binding site [chemical binding]; other site
483179004498	Mg2+ binding site [ion binding]; other site
483179004499	G-X-G motif; other site
483179004500	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
483179004501	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
483179004502	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
483179004503	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
483179004504	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
483179004505	Gram-negative bacterial tonB protein; Region: TonB; cl10048
483179004506	Predicted periplasmic protein [Function unknown]; Region: COG3698
483179004507	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
483179004508	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
483179004509	Walker A/P-loop; other site
483179004510	ATP binding site [chemical binding]; other site
483179004511	Q-loop/lid; other site
483179004512	ABC transporter signature motif; other site
483179004513	Walker B; other site
483179004514	D-loop; other site
483179004515	H-loop/switch region; other site
483179004516	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
483179004517	FtsX-like permease family; Region: FtsX; cl15850
483179004518	macrolide transporter subunit MacA; Provisional; Region: PRK11578
483179004519	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179004520	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179004521	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
483179004522	trimer interface [polypeptide binding]; other site
483179004523	active site
483179004524	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
483179004525	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179004526	dimerization interface [polypeptide binding]; other site
483179004527	putative DNA binding site [nucleotide binding]; other site
483179004528	putative Zn2+ binding site [ion binding]; other site
483179004529	AsnC family; Region: AsnC_trans_reg; pfam01037
483179004530	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
483179004531	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
483179004532	putative active site [active]
483179004533	putative dimer interface [polypeptide binding]; other site
483179004534	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
483179004535	diiron binding motif [ion binding]; other site
483179004536	Uncharacterized conserved protein [Function unknown]; Region: COG1633
483179004537	CCC1-related protein family; Region: CCC1_like_1; cd02437
483179004538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179004539	metabolite-proton symporter; Region: 2A0106; TIGR00883
483179004540	putative substrate translocation pore; other site
483179004541	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
483179004542	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
483179004543	GDP-binding site [chemical binding]; other site
483179004544	ACT binding site; other site
483179004545	IMP binding site; other site
483179004546	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
483179004547	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179004548	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
483179004549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179004550	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
483179004551	putative L-serine binding site [chemical binding]; other site
483179004552	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
483179004553	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
483179004554	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
483179004555	catalytic residue [active]
483179004556	serC leader; BCAN_A1726
483179004557	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179004558	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
483179004559	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
483179004560	active site
483179004561	substrate binding site [chemical binding]; other site
483179004562	metal binding site [ion binding]; metal-binding site
483179004563	FtsH Extracellular; Region: FtsH_ext; pfam06480
483179004564	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
483179004565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179004566	Walker A motif; other site
483179004567	ATP binding site [chemical binding]; other site
483179004568	Walker B motif; other site
483179004569	arginine finger; other site
483179004570	Peptidase family M41; Region: Peptidase_M41; pfam01434
483179004571	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
483179004572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
483179004573	Tetratricopeptide repeat; Region: TPR_6; pfam13174
483179004574	putative outer membrane lipoprotein; Provisional; Region: PRK09967
483179004575	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
483179004576	ligand binding site [chemical binding]; other site
483179004577	translocation protein TolB; Provisional; Region: tolB; PRK05137
483179004578	TolB amino-terminal domain; Region: TolB_N; cl00639
483179004579	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
483179004580	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
483179004581	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
483179004582	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
483179004583	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
483179004584	active site
483179004585	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
483179004586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179004587	Walker A motif; other site
483179004588	ATP binding site [chemical binding]; other site
483179004589	Walker B motif; other site
483179004590	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
483179004591	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
483179004592	RuvA N terminal domain; Region: RuvA_N; pfam01330
483179004593	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
483179004594	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
483179004595	active site
483179004596	putative DNA-binding cleft [nucleotide binding]; other site
483179004597	dimer interface [polypeptide binding]; other site
483179004598	Protein of unknown function (DUF1465); Region: DUF1465; cl11562
483179004599	OpgC protein; Region: OpgC_C; cl00792
483179004600	Acyltransferase family; Region: Acyl_transf_3; pfam01757
483179004601	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
483179004602	active site
483179004603	thiamine phosphate binding site [chemical binding]; other site
483179004604	pyrophosphate binding site [ion binding]; other site
483179004605	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
483179004606	Sel1 repeat; Region: Sel1; cl02723
483179004607	Sel1 repeat; Region: Sel1; cl02723
483179004608	Sel1 repeat; Region: Sel1; cl02723
483179004609	elongation factor P; Validated; Region: PRK00529
483179004610	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
483179004611	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
483179004612	RNA binding site [nucleotide binding]; other site
483179004613	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
483179004614	RNA binding site [nucleotide binding]; other site
483179004615	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
483179004616	active site
483179004617	dimerization interface [polypeptide binding]; other site
483179004618	hypothetical protein; Validated; Region: PRK09039
483179004619	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
483179004620	ligand binding site [chemical binding]; other site
483179004621	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
483179004622	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179004623	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179004624	Walker A/P-loop; other site
483179004625	ATP binding site [chemical binding]; other site
483179004626	Q-loop/lid; other site
483179004627	ABC transporter signature motif; other site
483179004628	Walker B; other site
483179004629	D-loop; other site
483179004630	H-loop/switch region; other site
483179004631	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
483179004632	Transcriptional regulator; Region: Transcrip_reg; cl00361
483179004633	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
483179004634	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
483179004635	Integral membrane protein TerC family; Region: TerC; cl10468
483179004636	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
483179004637	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
483179004638	putative active site [active]
483179004639	metal binding site [ion binding]; metal-binding site
483179004640	homodimer binding site [polypeptide binding]; other site
483179004641	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
483179004642	Cell division protein ZapA; Region: ZapA; cl01146
483179004643	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
483179004644	transketolase; Reviewed; Region: PRK05899
483179004645	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
483179004646	TPP-binding site [chemical binding]; other site
483179004647	dimer interface [polypeptide binding]; other site
483179004648	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
483179004649	PYR/PP interface [polypeptide binding]; other site
483179004650	dimer interface [polypeptide binding]; other site
483179004651	TPP binding site [chemical binding]; other site
483179004652	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
483179004653	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179004654	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
483179004655	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
483179004656	Phosphoglycerate kinase; Region: PGK; pfam00162
483179004657	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
483179004658	substrate binding site [chemical binding]; other site
483179004659	hinge regions; other site
483179004660	ADP binding site [chemical binding]; other site
483179004661	catalytic site [active]
483179004662	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
483179004663	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
483179004664	AMP-binding enzyme; Region: AMP-binding; cl15778
483179004665	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179004666	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179004667	Helix-turn-helix domains; Region: HTH; cl00088
483179004668	WYL domain; Region: WYL; cl14852
483179004669	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
483179004670	CoenzymeA binding site [chemical binding]; other site
483179004671	subunit interaction site [polypeptide binding]; other site
483179004672	PHB binding site; other site
483179004673	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
483179004674	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
483179004675	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
483179004676	NAD(P) binding site [chemical binding]; other site
483179004677	Protein of unknown function (DUF1192); Region: DUF1192; cl11573
483179004678	putative MFS family transporter protein; Provisional; Region: PRK03633
483179004679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179004680	putative substrate translocation pore; other site
483179004681	Protein of unknown function (DUF465); Region: DUF465; cl01070
483179004682	Protein of unknown function (DUF465); Region: DUF465; cl01070
483179004683	AIR carboxylase; Region: AIRC; cl00310
483179004684	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
483179004685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179004686	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179004687	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
483179004688	TPR repeat; Region: TPR_11; pfam13414
483179004689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
483179004690	TPR motif; other site
483179004691	binding surface
483179004692	pyruvate kinase; Provisional; Region: PRK06247
483179004693	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
483179004694	domain interfaces; other site
483179004695	active site
483179004696	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
483179004697	N-formylglutamate amidohydrolase; Region: FGase; cl01522
483179004698	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480
483179004699	ABC transporter ATPase component; Reviewed; Region: PRK11147
483179004700	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
483179004701	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
483179004702	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
483179004703	Thiamine pyrophosphokinase; Region: TPK; cd07995
483179004704	active site
483179004705	dimerization interface [polypeptide binding]; other site
483179004706	thiamine binding site [chemical binding]; other site
483179004707	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
483179004708	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179004709	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
483179004710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179004711	dimer interface [polypeptide binding]; other site
483179004712	conserved gate region; other site
483179004713	putative PBP binding loops; other site
483179004714	ABC-ATPase subunit interface; other site
483179004715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179004716	dimer interface [polypeptide binding]; other site
483179004717	conserved gate region; other site
483179004718	putative PBP binding loops; other site
483179004719	ABC-ATPase subunit interface; other site
483179004720	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
483179004721	ABC-type thiamine tranport system; part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP.  Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins...; Region: ABC_ThiQ_thiamine_transporter; cd03298
483179004722	Walker A/P-loop; other site
483179004723	ATP binding site [chemical binding]; other site
483179004724	Q-loop/lid; other site
483179004725	ABC transporter signature motif; other site
483179004726	Walker B; other site
483179004727	D-loop; other site
483179004728	H-loop/switch region; other site
483179004729	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
483179004730	Peptidase family M48; Region: Peptidase_M48; cl12018
483179004731	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
483179004732	MOSC domain; Region: MOSC; pfam03473
483179004733	3-alpha domain; Region: 3-alpha; pfam03475
483179004734	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
483179004735	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
483179004736	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
483179004737	DNA binding residues [nucleotide binding]
483179004738	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
483179004739	Ferredoxin [Energy production and conversion]; Region: COG1146
483179004740	4Fe-4S binding domain; Region: Fer4; cl02805
483179004741	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
483179004742	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
483179004743	RNA binding surface [nucleotide binding]; other site
483179004744	putative acyltransferase; Provisional; Region: PRK05790
483179004745	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
483179004746	dimer interface [polypeptide binding]; other site
483179004747	active site
483179004748	Domain of unknown function (DUF336); Region: DUF336; cl01249
483179004749	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
483179004750	Transglycosylase; Region: Transgly; cl07896
483179004751	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
483179004752	substrate binding pocket [chemical binding]; other site
483179004753	chain length determination region; other site
483179004754	substrate-Mg2+ binding site; other site
483179004755	catalytic residues [active]
483179004756	aspartate-rich region 1; other site
483179004757	active site lid residues [active]
483179004758	aspartate-rich region 2; other site
483179004759	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
483179004760	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
483179004761	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
483179004762	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
483179004763	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179004764	NAD(P) binding site [chemical binding]; other site
483179004765	active site
483179004766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179004767	putative substrate translocation pore; other site
483179004768	pyruvate carboxylase; Reviewed; Region: PRK12999
483179004769	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
483179004770	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179004771	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
483179004772	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
483179004773	active site
483179004774	catalytic residues [active]
483179004775	metal binding site [ion binding]; metal-binding site
483179004776	homodimer binding site [polypeptide binding]; other site
483179004777	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
483179004778	carboxyltransferase (CT) interaction site; other site
483179004779	biotinylation site [posttranslational modification]; other site
483179004780	leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404
483179004781	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
483179004782	dimerization interface [polypeptide binding]; other site
483179004783	ligand binding site [chemical binding]; other site
483179004784	leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404
483179004785	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
483179004786	dimerization interface [polypeptide binding]; other site
483179004787	ligand binding site [chemical binding]; other site
483179004788	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
483179004789	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
483179004790	Walker A/P-loop; other site
483179004791	ATP binding site [chemical binding]; other site
483179004792	Q-loop/lid; other site
483179004793	ABC transporter signature motif; other site
483179004794	Walker B; other site
483179004795	D-loop; other site
483179004796	H-loop/switch region; other site
483179004797	Uncharacterized conserved protein [Function unknown]; Region: COG3743
483179004798	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
483179004799	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
483179004800	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
483179004801	TM-ABC transporter signature motif; other site
483179004802	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
483179004803	TM-ABC transporter signature motif; other site
483179004804	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
483179004805	Proline racemase; Region: Pro_racemase; pfam05544
483179004806	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
483179004807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179004808	Helix-turn-helix domains; Region: HTH; cl00088
483179004809	transcriptional regulator SlyA; Provisional; Region: PRK03573
483179004810	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
483179004811	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
483179004812	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
483179004813	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
483179004814	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
483179004815	alpha subunit interaction interface [polypeptide binding]; other site
483179004816	Walker A motif; other site
483179004817	ATP binding site [chemical binding]; other site
483179004818	Walker B motif; other site
483179004819	inhibitor binding site; inhibition site
483179004820	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
483179004821	ATP synthase; Region: ATP-synt; cl00365
483179004822	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
483179004823	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
483179004824	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
483179004825	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
483179004826	beta subunit interaction interface [polypeptide binding]; other site
483179004827	Walker A motif; other site
483179004828	ATP binding site [chemical binding]; other site
483179004829	Walker B motif; other site
483179004830	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
483179004831	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
483179004832	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
483179004833	primosome assembly protein PriA; Validated; Region: PRK05580
483179004834	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
483179004835	ATP binding site [chemical binding]; other site
483179004836	putative Mg++ binding site [ion binding]; other site
483179004837	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179004838	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
483179004839	active site
483179004840	intersubunit interactions; other site
483179004841	catalytic residue [active]
483179004842	Lipopolysaccharide-assembly; Region: LptE; cl01125
483179004843	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
483179004844	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
483179004845	HIGH motif; other site
483179004846	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
483179004847	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
483179004848	active site
483179004849	KMSKS motif; other site
483179004850	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
483179004851	tRNA binding surface [nucleotide binding]; other site
483179004852	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
483179004853	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
483179004854	catalytic residue [active]
483179004855	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
483179004856	Usg-like family; Region: Usg; cl11567
483179004857	acetyl-CoA synthetase; Provisional; Region: PRK00174
483179004858	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
483179004859	AMP-binding enzyme; Region: AMP-binding; cl15778
483179004860	AMP-binding enzyme; Region: AMP-binding; cl15778
483179004861	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179004862	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
483179004863	Peptidase family M48; Region: Peptidase_M48; cl12018
483179004864	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
483179004865	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
483179004866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179004867	S-adenosylmethionine binding site [chemical binding]; other site
483179004868	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
483179004869	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
483179004870	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
483179004871	purine monophosphate binding site [chemical binding]; other site
483179004872	dimer interface [polypeptide binding]; other site
483179004873	putative catalytic residues [active]
483179004874	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
483179004875	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
483179004876	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
483179004877	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
483179004878	Repair protein; Region: Repair_PSII; cl01535
483179004879	Repair protein; Region: Repair_PSII; cl01535
483179004880	LemA family; Region: LemA; cl00742
483179004881	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
483179004882	Chorismate mutase type II; Region: CM_2; cl00693
483179004883	signal recognition particle protein; Provisional; Region: PRK10867
483179004884	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
483179004885	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
483179004886	P loop; other site
483179004887	GTP binding site [chemical binding]; other site
483179004888	Signal peptide binding domain; Region: SRP_SPB; pfam02978
483179004889	lytic murein transglycosylase; Region: MltB_2; TIGR02283
483179004890	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
483179004891	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
483179004892	active site clefts [active]
483179004893	zinc binding site [ion binding]; other site
483179004894	dimer interface [polypeptide binding]; other site
483179004895	pyridoxamine kinase; Validated; Region: PRK05756
483179004896	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
483179004897	dimer interface [polypeptide binding]; other site
483179004898	pyridoxal binding site [chemical binding]; other site
483179004899	ATP binding site [chemical binding]; other site
483179004900	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
483179004901	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179004902	tetrameric interface [polypeptide binding]; other site
483179004903	NAD binding site [chemical binding]; other site
483179004904	catalytic residues [active]
483179004905	Transcriptional regulator [Transcription]; Region: LysR; COG0583
483179004906	Helix-turn-helix domains; Region: HTH; cl00088
483179004907	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
483179004908	putative effector binding pocket; other site
483179004909	dimerization interface [polypeptide binding]; other site
483179004910	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
483179004911	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
483179004912	putative active site [active]
483179004913	Ap4A binding site [chemical binding]; other site
483179004914	nudix motif; other site
483179004915	putative metal binding site [ion binding]; other site
483179004916	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
483179004917	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
483179004918	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
483179004919	protein binding site [polypeptide binding]; other site
483179004920	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
483179004921	Catalytic dyad [active]
483179004922	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
483179004923	Oligomerisation domain; Region: Oligomerisation; cl00519
483179004924	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
483179004925	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
483179004926	active site
483179004927	(T/H)XGH motif; other site
483179004928	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
483179004929	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
483179004930	putative catalytic cysteine [active]
483179004931	gamma-glutamyl kinase; Provisional; Region: PRK05429
483179004932	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
483179004933	nucleotide binding site [chemical binding]; other site
483179004934	homotetrameric interface [polypeptide binding]; other site
483179004935	putative phosphate binding site [ion binding]; other site
483179004936	putative allosteric binding site; other site
483179004937	PUA domain; Region: PUA; cl00607
483179004938	GTPase CgtA; Reviewed; Region: obgE; PRK12299
483179004939	GTP1/OBG; Region: GTP1_OBG; pfam01018
483179004940	Obg GTPase; Region: Obg; cd01898
483179004941	G1 box; other site
483179004942	GTP/Mg2+ binding site [chemical binding]; other site
483179004943	Switch I region; other site
483179004944	G2 box; other site
483179004945	G3 box; other site
483179004946	Switch II region; other site
483179004947	G4 box; other site
483179004948	G5 box; other site
483179004949	YadA-like C-terminal region; Region: YadA; pfam03895
483179004950	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
483179004951	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179004952	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
483179004953	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179004954	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
483179004955	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
483179004956	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
483179004957	Integrase core domain; Region: rve; cl01316
483179004958	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
483179004959	Cupin domain; Region: Cupin_2; cl09118
483179004960	Methyltransferase domain; Region: Methyltransf_31; pfam13847
483179004961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179004962	S-adenosylmethionine binding site [chemical binding]; other site
483179004963	AzlC protein; Region: AzlC; cl00570
483179004964	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
483179004965	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
483179004966	Integrase core domain; Region: rve; cl01316
483179004967	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
483179004968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
483179004969	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179004970	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
483179004971	Clp amino terminal domain; Region: Clp_N; pfam02861
483179004972	Clp amino terminal domain; Region: Clp_N; pfam02861
483179004973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179004974	Walker A motif; other site
483179004975	ATP binding site [chemical binding]; other site
483179004976	Walker B motif; other site
483179004977	arginine finger; other site
483179004978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179004979	Walker A motif; other site
483179004980	ATP binding site [chemical binding]; other site
483179004981	Walker B motif; other site
483179004982	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
483179004983	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
483179004984	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
483179004985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179004986	S-adenosylmethionine binding site [chemical binding]; other site
483179004987	peptide chain release factor 1; Validated; Region: prfA; PRK00591
483179004988	RF-1 domain; Region: RF-1; cl02875
483179004989	RF-1 domain; Region: RF-1; cl02875
483179004990	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
483179004991	GAF domain; Region: GAF; cl15785
483179004992	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
483179004993	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
483179004994	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
483179004995	aspartate kinase; Reviewed; Region: PRK06635
483179004996	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
483179004997	putative nucleotide binding site [chemical binding]; other site
483179004998	putative catalytic residues [active]
483179004999	putative Mg ion binding site [ion binding]; other site
483179005000	putative aspartate binding site [chemical binding]; other site
483179005001	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
483179005002	putative allosteric regulatory site; other site
483179005003	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
483179005004	putative allosteric regulatory residue; other site
483179005005	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
483179005006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179005007	S-adenosylmethionine binding site [chemical binding]; other site
483179005008	EamA-like transporter family; Region: EamA; cl01037
483179005009	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
483179005010	Predicted amidohydrolase [General function prediction only]; Region: COG0388
483179005011	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
483179005012	putative active site [active]
483179005013	catalytic triad [active]
483179005014	dimer interface [polypeptide binding]; other site
483179005015	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
483179005016	GSH binding site [chemical binding]; other site
483179005017	catalytic residues [active]
483179005018	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
483179005019	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
483179005020	active site
483179005021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179005022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179005023	putative substrate translocation pore; other site
483179005024	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
483179005025	putative metal binding site [ion binding]; other site
483179005026	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
483179005027	HemY protein N-terminus; Region: HemY_N; pfam07219
483179005028	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
483179005029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
483179005030	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
483179005031	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
483179005032	active site
483179005033	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
483179005034	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
483179005035	domain interfaces; other site
483179005036	active site
483179005037	UGMP family protein; Validated; Region: PRK09604
483179005038	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
483179005039	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
483179005040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005041	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
483179005042	YCII-related domain; Region: YCII; cl00999
483179005043	EVE domain; Region: EVE; cl00728
483179005044	Predicted methyltransferase [General function prediction only]; Region: COG3897
483179005045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179005046	S-adenosylmethionine binding site [chemical binding]; other site
483179005047	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
483179005048	EamA-like transporter family; Region: EamA; cl01037
483179005049	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
483179005050	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179005051	DNA-binding site [nucleotide binding]; DNA binding site
483179005052	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
483179005053	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179005054	homodimer interface [polypeptide binding]; other site
483179005055	catalytic residue [active]
483179005056	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
483179005057	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005058	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
483179005059	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
483179005060	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
483179005061	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
483179005062	active site
483179005063	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
483179005064	catalytic triad [active]
483179005065	dimer interface [polypeptide binding]; other site
483179005066	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
483179005067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005068	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
483179005069	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179005070	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
483179005071	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
483179005072	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
483179005073	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005074	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
483179005075	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
483179005076	putative SdhC subunit interface [polypeptide binding]; other site
483179005077	putative proximal heme binding site [chemical binding]; other site
483179005078	putative Iron-sulfur protein interface [polypeptide binding]; other site
483179005079	putative proximal quinone binding site; other site
483179005080	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
483179005081	Iron-sulfur protein interface; other site
483179005082	proximal quinone binding site [chemical binding]; other site
483179005083	SdhD (CybS) interface [polypeptide binding]; other site
483179005084	proximal heme binding site [chemical binding]; other site
483179005085	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
483179005086	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
483179005087	Coenzyme A binding pocket [chemical binding]; other site
483179005088	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
483179005089	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
483179005090	substrate binding site [chemical binding]; other site
483179005091	ligand binding site [chemical binding]; other site
483179005092	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
483179005093	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
483179005094	Na binding site [ion binding]; other site
483179005095	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
483179005096	NIPSNAP; Region: NIPSNAP; pfam07978
483179005097	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179005098	dimerization interface [polypeptide binding]; other site
483179005099	putative DNA binding site [nucleotide binding]; other site
483179005100	putative Zn2+ binding site [ion binding]; other site
483179005101	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
483179005102	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
483179005103	RimM N-terminal domain; Region: RimM; pfam01782
483179005104	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
483179005105	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
483179005106	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
483179005107	active site
483179005108	DNA binding site [nucleotide binding]
483179005109	Int/Topo IB signature motif; other site
483179005110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
483179005111	TraB family; Region: TraB; cl12050
483179005112	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
483179005113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005114	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179005115	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
483179005116	LysE type translocator; Region: LysE; cl00565
483179005117	MAPEG family; Region: MAPEG; cl09190
483179005118	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
483179005119	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
483179005120	E3 interaction surface; other site
483179005121	lipoyl attachment site [posttranslational modification]; other site
483179005122	e3 binding domain; Region: E3_binding; pfam02817
483179005123	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
483179005124	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
483179005125	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
483179005126	TPP-binding site [chemical binding]; other site
483179005127	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
483179005128	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
483179005129	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005130	CoA-ligase; Region: Ligase_CoA; cl02894
483179005131	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
483179005132	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179005133	CoA-ligase; Region: Ligase_CoA; cl02894
483179005134	malate dehydrogenase; Reviewed; Region: PRK06223
483179005135	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
483179005136	NAD(P) binding site [chemical binding]; other site
483179005137	dimer interface [polypeptide binding]; other site
483179005138	tetramer (dimer of dimers) interface [polypeptide binding]; other site
483179005139	substrate binding site [chemical binding]; other site
483179005140	Predicted ATPase [General function prediction only]; Region: COG1485
483179005141	Protease inhibitor Inh; Region: Inh; pfam02974
483179005142	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
483179005143	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
483179005144	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
483179005145	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
483179005146	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
483179005147	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179005148	FeS/SAM binding site; other site
483179005149	2-oxoglutarate dehydrogenase E2 component; Region: PLN02226
483179005150	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
483179005151	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
483179005152	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005153	Intracellular septation protein A; Region: IspA; cl01098
483179005154	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
483179005155	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
483179005156	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
483179005157	active site
483179005158	8-oxo-dGMP binding site [chemical binding]; other site
483179005159	nudix motif; other site
483179005160	metal binding site [ion binding]; metal-binding site
483179005161	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179005162	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
483179005163	heterotetramer interface [polypeptide binding]; other site
483179005164	active site pocket [active]
483179005165	cleavage site
483179005166	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
483179005167	PPIC-type PPIASE domain; Region: Rotamase; cl08278
483179005168	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
483179005169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005170	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
483179005171	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005172	nucleotide binding region [chemical binding]; other site
483179005173	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
483179005174	SEC-C motif; Region: SEC-C; pfam02810
483179005175	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179005176	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
483179005177	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
483179005178	Sulfatase; Region: Sulfatase; cl10460
483179005179	Transcriptional regulator [Transcription]; Region: LysR; COG0583
483179005180	Helix-turn-helix domains; Region: HTH; cl00088
483179005181	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
483179005182	dimerization interface [polypeptide binding]; other site
483179005183	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
483179005184	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
483179005185	substrate binding pocket [chemical binding]; other site
483179005186	membrane-bound complex binding site; other site
483179005187	hinge residues; other site
483179005188	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
483179005189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179005190	dimer interface [polypeptide binding]; other site
483179005191	conserved gate region; other site
483179005192	putative PBP binding loops; other site
483179005193	ABC-ATPase subunit interface; other site
483179005194	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
483179005195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179005196	dimer interface [polypeptide binding]; other site
483179005197	conserved gate region; other site
483179005198	putative PBP binding loops; other site
483179005199	ABC-ATPase subunit interface; other site
483179005200	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
483179005201	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
483179005202	Walker A/P-loop; other site
483179005203	ATP binding site [chemical binding]; other site
483179005204	Q-loop/lid; other site
483179005205	ABC transporter signature motif; other site
483179005206	Walker B; other site
483179005207	D-loop; other site
483179005208	H-loop/switch region; other site
483179005209	Arginase family; Region: Arginase; cl00306
483179005210	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
483179005211	Aspartase; Region: Aspartase; cd01357
483179005212	active sites [active]
483179005213	tetramer interface [polypeptide binding]; other site
483179005214	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
483179005215	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
483179005216	Walker A/P-loop; other site
483179005217	ATP binding site [chemical binding]; other site
483179005218	Q-loop/lid; other site
483179005219	ABC transporter signature motif; other site
483179005220	Walker B; other site
483179005221	D-loop; other site
483179005222	H-loop/switch region; other site
483179005223	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
483179005224	active site
483179005225	homotetramer interface [polypeptide binding]; other site
483179005226	homodimer interface [polypeptide binding]; other site
483179005227	Transcriptional regulators [Transcription]; Region: GntR; COG1802
483179005228	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179005229	DNA-binding site [nucleotide binding]; DNA binding site
483179005230	FCD domain; Region: FCD; cl11656
483179005231	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
483179005232	active site
483179005233	homotetramer interface [polypeptide binding]; other site
483179005234	homodimer interface [polypeptide binding]; other site
483179005235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179005236	D-galactonate transporter; Region: 2A0114; TIGR00893
483179005237	putative substrate translocation pore; other site
483179005238	methionine gamma-lyase; Validated; Region: PRK07049
483179005239	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
483179005240	homodimer interface [polypeptide binding]; other site
483179005241	substrate-cofactor binding pocket; other site
483179005242	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179005243	catalytic residue [active]
483179005244	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
483179005245	Ligand Binding Site [chemical binding]; other site
483179005246	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
483179005247	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
483179005248	dimer interface [polypeptide binding]; other site
483179005249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179005250	catalytic residue [active]
483179005251	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
483179005252	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005253	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
483179005254	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
483179005255	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
483179005256	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
483179005257	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
483179005258	Ligand binding site [chemical binding]; other site
483179005259	Electron transfer flavoprotein domain; Region: ETF; pfam01012
483179005260	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
483179005261	Ligand Binding Site [chemical binding]; other site
483179005262	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
483179005263	active site
483179005264	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
483179005265	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
483179005266	short chain dehydrogenase; Validated; Region: PRK06182
483179005267	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
483179005268	NADP binding site [chemical binding]; other site
483179005269	active site
483179005270	steroid binding site; other site
483179005271	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
483179005272	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
483179005273	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
483179005274	catalytic residues [active]
483179005275	argininosuccinate lyase; Provisional; Region: PRK00855
483179005276	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
483179005277	active sites [active]
483179005278	tetramer interface [polypeptide binding]; other site
483179005279	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
483179005280	diaminopimelate decarboxylase; Region: lysA; TIGR01048
483179005281	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
483179005282	active site
483179005283	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
483179005284	substrate binding site [chemical binding]; other site
483179005285	catalytic residues [active]
483179005286	dimer interface [polypeptide binding]; other site
483179005287	TIGR02302 family protein; Region: aProt_lowcomp
483179005288	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
483179005289	active site
483179005290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179005291	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
483179005292	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
483179005293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179005294	homodimer interface [polypeptide binding]; other site
483179005295	catalytic residue [active]
483179005296	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
483179005297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
483179005299	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
483179005300	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
483179005301	putative active site pocket [active]
483179005302	dimerization interface [polypeptide binding]; other site
483179005303	putative catalytic residue [active]
483179005304	YGGT family; Region: YGGT; cl00508
483179005305	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
483179005306	dimer interface [polypeptide binding]; other site
483179005307	substrate binding site [chemical binding]; other site
483179005308	metal binding sites [ion binding]; metal-binding site
483179005309	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
483179005310	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
483179005311	putative acyl-acceptor binding pocket; other site
483179005312	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
483179005313	putative active site [active]
483179005314	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
483179005315	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
483179005316	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005317	Walker A/P-loop; other site
483179005318	ATP binding site [chemical binding]; other site
483179005319	Q-loop/lid; other site
483179005320	ABC transporter signature motif; other site
483179005321	Walker B; other site
483179005322	D-loop; other site
483179005323	H-loop/switch region; other site
483179005324	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
483179005325	amphipathic channel; other site
483179005326	Asn-Pro-Ala signature motifs; other site
483179005327	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
483179005328	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
483179005329	putative catalytic site [active]
483179005330	putative phosphate binding site [ion binding]; other site
483179005331	active site
483179005332	metal binding site A [ion binding]; metal-binding site
483179005333	DNA binding site [nucleotide binding]
483179005334	putative AP binding site [nucleotide binding]; other site
483179005335	putative metal binding site B [ion binding]; other site
483179005336	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
483179005337	ligand binding site [chemical binding]; other site
483179005338	flexible hinge region; other site
483179005339	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
483179005340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179005341	active site
483179005342	phosphorylation site [posttranslational modification]
483179005343	intermolecular recognition site; other site
483179005344	dimerization interface [polypeptide binding]; other site
483179005345	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179005346	DNA binding site [nucleotide binding]
483179005347	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179005348	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
483179005349	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
483179005350	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
483179005351	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
483179005352	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
483179005353	DNA binding residues [nucleotide binding]
483179005354	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
483179005355	dimer interface [polypeptide binding]; other site
483179005356	putative metal binding site [ion binding]; other site
483179005357	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
483179005358	metal-binding site [ion binding]
483179005359	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
483179005360	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
483179005361	metal-binding site [ion binding]
483179005362	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
483179005363	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179005364	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
483179005365	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
483179005366	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
483179005367	metal ion-dependent adhesion site (MIDAS); other site
483179005368	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
483179005369	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
483179005370	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005371	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
483179005372	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
483179005373	HSP70 interaction site [polypeptide binding]; other site
483179005374	BolA-like protein; Region: BolA; cl00386
483179005375	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
483179005376	Domain of unknown function DUF21; Region: DUF21; pfam01595
483179005377	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
483179005378	Transporter associated domain; Region: CorC_HlyC; cl08393
483179005379	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
483179005380	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
483179005381	active site
483179005382	dimer interface [polypeptide binding]; other site
483179005383	metal binding site [ion binding]; metal-binding site
483179005384	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
483179005385	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
483179005386	ADP binding site [chemical binding]; other site
483179005387	magnesium binding site [ion binding]; other site
483179005388	putative shikimate binding site; other site
483179005389	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
483179005390	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
483179005391	active site
483179005392	DNA binding site [nucleotide binding]
483179005393	Int/Topo IB signature motif; other site
483179005394	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
483179005395	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
483179005396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
483179005397	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
483179005398	CPxP  motif; other site
483179005399	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
483179005400	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005401	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
483179005402	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
483179005403	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179005404	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
483179005405	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
483179005406	metal binding site [ion binding]; metal-binding site
483179005407	putative dimer interface [polypeptide binding]; other site
483179005408	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
483179005409	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005410	NAD(P) binding site [chemical binding]; other site
483179005411	active site
483179005412	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
483179005413	Domain of unknown function (DUF4354); Region: DUF4354; pfam14263
483179005414	choline dehydrogenase; Validated; Region: PRK02106
483179005415	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005416	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
483179005417	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
483179005418	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005419	NAD(P) binding site [chemical binding]; other site
483179005420	active site
483179005421	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
483179005422	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
483179005423	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179005424	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
483179005425	NAD(P) binding site [chemical binding]; other site
483179005426	catalytic residues [active]
483179005427	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
483179005428	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
483179005429	substrate binding site [chemical binding]; other site
483179005430	oxyanion hole (OAH) forming residues; other site
483179005431	trimer interface [polypeptide binding]; other site
483179005432	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179005433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005434	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
483179005435	Transcriptional regulators [Transcription]; Region: PurR; COG1609
483179005436	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
483179005437	DNA binding site [nucleotide binding]
483179005438	domain linker motif; other site
483179005439	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
483179005440	putative dimerization interface [polypeptide binding]; other site
483179005441	putative ligand binding site [chemical binding]; other site
483179005442	Protein of unknown function (DUF993); Region: DUF993; pfam06187
483179005443	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
483179005444	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
483179005445	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
483179005446	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
483179005447	zinc binding site [ion binding]; other site
483179005448	putative ligand binding site [chemical binding]; other site
483179005449	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
483179005450	TM-ABC transporter signature motif; other site
483179005451	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
483179005452	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
483179005453	Walker A/P-loop; other site
483179005454	ATP binding site [chemical binding]; other site
483179005455	Q-loop/lid; other site
483179005456	ABC transporter signature motif; other site
483179005457	Walker B; other site
483179005458	D-loop; other site
483179005459	H-loop/switch region; other site
483179005460	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
483179005461	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
483179005462	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
483179005463	ParB-like nuclease domain; Region: ParBc; cl02129
483179005464	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
483179005465	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
483179005466	P-loop; other site
483179005467	Magnesium ion binding site [ion binding]; other site
483179005468	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
483179005469	Magnesium ion binding site [ion binding]; other site
483179005470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179005471	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
483179005472	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005474	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
483179005475	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
483179005476	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
483179005477	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005478	trmE is a tRNA modification GTPase; Region: trmE; cd04164
483179005479	G1 box; other site
483179005480	G1 box; other site
483179005481	GTP/Mg2+ binding site [chemical binding]; other site
483179005482	GTP/Mg2+ binding site [chemical binding]; other site
483179005483	Switch I region; other site
483179005484	Switch I region; other site
483179005485	G2 box; other site
483179005486	G2 box; other site
483179005487	Switch II region; other site
483179005488	G3 box; other site
483179005489	G4 box; other site
483179005490	G5 box; other site
483179005491	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
483179005492	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
483179005493	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
483179005494	catalytic residues [active]
483179005495	transcription termination factor Rho; Provisional; Region: rho; PRK09376
483179005496	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
483179005497	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
483179005498	RNA binding site [nucleotide binding]; other site
483179005499	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
483179005500	multimer interface [polypeptide binding]; other site
483179005501	Walker A motif; other site
483179005502	ATP binding site [chemical binding]; other site
483179005503	Walker B motif; other site
483179005504	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
483179005505	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
483179005506	substrate binding site [chemical binding]; other site
483179005507	active site
483179005508	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
483179005509	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
483179005510	active site
483179005511	dimer interface [polypeptide binding]; other site
483179005512	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
483179005513	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
483179005514	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
483179005515	shikimate binding site; other site
483179005516	NAD(P) binding site [chemical binding]; other site
483179005517	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
483179005518	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
483179005519	CoA-binding site [chemical binding]; other site
483179005520	ATP-binding [chemical binding]; other site
483179005521	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
483179005522	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
483179005523	active site
483179005524	catalytic site [active]
483179005525	substrate binding site [chemical binding]; other site
483179005526	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
483179005527	SecA binding site; other site
483179005528	Preprotein binding site; other site
483179005529	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
483179005530	Tim44-like domain; Region: Tim44; cl09208
483179005531	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
483179005532	MltA specific insert domain; Region: MltA; cl08398
483179005533	3D domain; Region: 3D; cl01439
483179005534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
483179005535	Smr domain; Region: Smr; cl02619
483179005536	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
483179005537	sequence-specific DNA binding site [nucleotide binding]; other site
483179005538	salt bridge; other site
483179005539	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
483179005540	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
483179005541	active site
483179005542	HslU subunit interaction site [polypeptide binding]; other site
483179005543	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
483179005544	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
483179005545	putative active site pocket [active]
483179005546	4-fold oligomerization interface [polypeptide binding]; other site
483179005547	metal binding residues [ion binding]; metal-binding site
483179005548	3-fold/trimer interface [polypeptide binding]; other site
483179005549	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
483179005550	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
483179005551	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
483179005552	putative active site [active]
483179005553	oxyanion strand; other site
483179005554	catalytic triad [active]
483179005555	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
483179005556	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
483179005557	catalytic residues [active]
483179005558	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
483179005559	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
483179005560	substrate binding site [chemical binding]; other site
483179005561	glutamase interaction surface [polypeptide binding]; other site
483179005562	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
483179005563	metal binding site [ion binding]; metal-binding site
483179005564	pantothenate kinase; Provisional; Region: PRK05439
483179005565	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
483179005566	ATP-binding site [chemical binding]; other site
483179005567	CoA-binding site [chemical binding]; other site
483179005568	Mg2+-binding site [ion binding]; other site
483179005569	RF-1 domain; Region: RF-1; cl02875
483179005570	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
483179005571	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
483179005572	active site
483179005573	substrate-binding site [chemical binding]; other site
483179005574	metal-binding site [ion binding]
483179005575	ATP binding site [chemical binding]; other site
483179005576	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
483179005577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179005578	active site
483179005579	phosphorylation site [posttranslational modification]
483179005580	intermolecular recognition site; other site
483179005581	dimerization interface [polypeptide binding]; other site
483179005582	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179005583	DNA binding site [nucleotide binding]
483179005584	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
483179005585	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
483179005586	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
483179005587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
483179005588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179005589	dimer interface [polypeptide binding]; other site
483179005590	phosphorylation site [posttranslational modification]
483179005591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179005592	ATP binding site [chemical binding]; other site
483179005593	Mg2+ binding site [ion binding]; other site
483179005594	G-X-G motif; other site
483179005595	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
483179005596	Hpr binding site; other site
483179005597	active site
483179005598	homohexamer subunit interaction site [polypeptide binding]; other site
483179005599	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
483179005600	active pocket/dimerization site; other site
483179005601	active site
483179005602	phosphorylation site [posttranslational modification]
483179005603	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
483179005604	dimerization domain swap beta strand [polypeptide binding]; other site
483179005605	regulatory protein interface [polypeptide binding]; other site
483179005606	active site
483179005607	regulatory phosphorylation site [posttranslational modification]; other site
483179005608	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
483179005609	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
483179005610	oligomerization interface [polypeptide binding]; other site
483179005611	active site
483179005612	NAD+ binding site [chemical binding]; other site
483179005613	PAS fold; Region: PAS_7; pfam12860
483179005614	PAS fold; Region: PAS_7; pfam12860
483179005615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179005616	dimer interface [polypeptide binding]; other site
483179005617	phosphorylation site [posttranslational modification]
483179005618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179005619	ATP binding site [chemical binding]; other site
483179005620	Mg2+ binding site [ion binding]; other site
483179005621	G-X-G motif; other site
483179005622	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
483179005623	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179005624	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
483179005625	Substrate binding site; other site
483179005626	metal-binding site
483179005627	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
483179005628	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
483179005629	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
483179005630	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
483179005631	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005632	Family description; Region: UvrD_C_2; cl15862
483179005633	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
483179005634	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
483179005635	catalytic residues [active]
483179005636	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
483179005637	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
483179005638	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
483179005639	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
483179005640	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
483179005641	substrate binding site [chemical binding]; other site
483179005642	active site
483179005643	catalytic residues [active]
483179005644	heterodimer interface [polypeptide binding]; other site
483179005645	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
483179005646	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
483179005647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179005648	catalytic residue [active]
483179005649	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
483179005650	active site
483179005651	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
483179005652	putative active site [active]
483179005653	Protein of unknown function DUF45; Region: DUF45; cl00636
483179005654	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
483179005655	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
483179005656	benzoate transporter; Region: benE; TIGR00843
483179005657	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
483179005658	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
483179005659	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
483179005660	Phospholipid methyltransferase; Region: PEMT; cl00763
483179005661	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
483179005662	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
483179005663	23S rRNA binding site [nucleotide binding]; other site
483179005664	L21 binding site [polypeptide binding]; other site
483179005665	L13 binding site [polypeptide binding]; other site
483179005666	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
483179005667	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
483179005668	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
483179005669	dimer interface [polypeptide binding]; other site
483179005670	motif 1; other site
483179005671	active site
483179005672	motif 2; other site
483179005673	motif 3; other site
483179005674	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
483179005675	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
483179005676	putative tRNA-binding site [nucleotide binding]; other site
483179005677	B3/4 domain; Region: B3_4; cl11458
483179005678	tRNA synthetase B5 domain; Region: B5; cl08394
483179005679	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
483179005680	dimer interface [polypeptide binding]; other site
483179005681	motif 1; other site
483179005682	motif 3; other site
483179005683	motif 2; other site
483179005684	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
483179005685	NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712
483179005686	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179005687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005688	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
483179005689	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
483179005690	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
483179005691	catalytic site [active]
483179005692	metal binding site [ion binding]; metal-binding site
483179005693	chaperone protein DnaJ; Provisional; Region: PRK10767
483179005694	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
483179005695	HSP70 interaction site [polypeptide binding]; other site
483179005696	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
483179005697	substrate binding site [polypeptide binding]; other site
483179005698	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
483179005699	Zn binding sites [ion binding]; other site
483179005700	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
483179005701	dimer interface [polypeptide binding]; other site
483179005702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179005703	S-adenosylmethionine binding site [chemical binding]; other site
483179005704	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
483179005705	active site
483179005706	dimer interface [polypeptide binding]; other site
483179005707	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
483179005708	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
483179005709	glutathione synthetase; Provisional; Region: PRK05246
483179005710	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
483179005711	ATP-grasp domain; Region: ATP-grasp_4; cl03087
483179005712	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
483179005713	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
483179005714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
483179005715	Walker A motif; other site
483179005716	ATP binding site [chemical binding]; other site
483179005717	Walker B motif; other site
483179005718	arginine finger; other site
483179005719	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
483179005720	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
483179005721	Protein of unknown function (DUF454); Region: DUF454; cl01063
483179005722	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179005723	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
483179005724	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
483179005725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179005726	dimer interface [polypeptide binding]; other site
483179005727	conserved gate region; other site
483179005728	putative PBP binding loops; other site
483179005729	ABC-ATPase subunit interface; other site
483179005730	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
483179005731	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
483179005732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179005733	dimer interface [polypeptide binding]; other site
483179005734	conserved gate region; other site
483179005735	putative PBP binding loops; other site
483179005736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
483179005737	ABC-ATPase subunit interface; other site
483179005738	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
483179005739	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
483179005740	Walker A/P-loop; other site
483179005741	ATP binding site [chemical binding]; other site
483179005742	Q-loop/lid; other site
483179005743	ABC transporter signature motif; other site
483179005744	Walker B; other site
483179005745	D-loop; other site
483179005746	H-loop/switch region; other site
483179005747	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
483179005748	PhoU domain; Region: PhoU; pfam01895
483179005749	PhoU domain; Region: PhoU; pfam01895
483179005750	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
483179005751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179005752	active site
483179005753	phosphorylation site [posttranslational modification]
483179005754	intermolecular recognition site; other site
483179005755	dimerization interface [polypeptide binding]; other site
483179005756	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179005757	DNA binding site [nucleotide binding]
483179005758	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
483179005759	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
483179005760	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
483179005761	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
483179005762	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
483179005763	dimerization interface [polypeptide binding]; other site
483179005764	DPS ferroxidase diiron center [ion binding]; other site
483179005765	ion pore; other site
483179005766	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
483179005767	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
483179005768	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179005769	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
483179005770	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
483179005771	putative acyl-acceptor binding pocket; other site
483179005772	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
483179005773	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
483179005774	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179005775	FeS/SAM binding site; other site
483179005776	TRAM domain; Region: TRAM; cl01282
483179005777	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
483179005778	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179005779	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
483179005780	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
483179005781	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
483179005782	Transporter associated domain; Region: CorC_HlyC; cl08393
483179005783	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
483179005784	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
483179005785	putative active site [active]
483179005786	catalytic triad [active]
483179005787	putative dimer interface [polypeptide binding]; other site
483179005788	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
483179005789	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
483179005790	non-specific DNA binding site [nucleotide binding]; other site
483179005791	salt bridge; other site
483179005792	sequence-specific DNA binding site [nucleotide binding]; other site
483179005793	S-adenosylmethionine synthetase; Validated; Region: PRK05250
483179005794	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
483179005795	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
483179005796	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
483179005797	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179005798	ribosome maturation protein RimP; Reviewed; Region: PRK00092
483179005799	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
483179005800	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
483179005801	Sm1 motif; other site
483179005802	D1 - D2 interaction site; other site
483179005803	D3 - B interaction site; other site
483179005804	Hfq - Hfq interaction site; other site
483179005805	RNA binding pocket [nucleotide binding]; other site
483179005806	Sm2 motif; other site
483179005807	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
483179005808	NusA N-terminal domain; Region: NusA_N; pfam08529
483179005809	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
483179005810	RNA binding site [nucleotide binding]; other site
483179005811	homodimer interface [polypeptide binding]; other site
483179005812	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
483179005813	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
483179005814	G-X-X-G motif; other site
483179005815	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
483179005816	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
483179005817	putative RNA binding cleft [nucleotide binding]; other site
483179005818	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
483179005819	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
483179005820	translation initiation factor IF-2; Region: IF-2; TIGR00487
483179005821	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
483179005822	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
483179005823	G1 box; other site
483179005824	putative GEF interaction site [polypeptide binding]; other site
483179005825	GTP/Mg2+ binding site [chemical binding]; other site
483179005826	Switch I region; other site
483179005827	G2 box; other site
483179005828	G3 box; other site
483179005829	Switch II region; other site
483179005830	G4 box; other site
483179005831	G5 box; other site
483179005832	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
483179005833	Translation-initiation factor 2; Region: IF-2; pfam11987
483179005834	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
483179005835	Ribosome-binding factor A; Region: RBFA; cl00542
483179005836	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
483179005837	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
483179005838	RNA binding site [nucleotide binding]; other site
483179005839	active site
483179005840	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
483179005841	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
483179005842	16S/18S rRNA binding site [nucleotide binding]; other site
483179005843	S13e-L30e interaction site [polypeptide binding]; other site
483179005844	25S rRNA binding site [nucleotide binding]; other site
483179005845	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
483179005846	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
483179005847	RNase E interface [polypeptide binding]; other site
483179005848	trimer interface [polypeptide binding]; other site
483179005849	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
483179005850	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
483179005851	RNase E interface [polypeptide binding]; other site
483179005852	trimer interface [polypeptide binding]; other site
483179005853	active site
483179005854	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
483179005855	putative nucleic acid binding region [nucleotide binding]; other site
483179005856	G-X-X-G motif; other site
483179005857	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
483179005858	RNA binding site [nucleotide binding]; other site
483179005859	domain interface; other site
483179005860	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
483179005861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179005862	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
483179005863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005864	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
483179005865	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
483179005866	dimer interface [polypeptide binding]; other site
483179005867	active site
483179005868	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
483179005869	active site 1 [active]
483179005870	dimer interface [polypeptide binding]; other site
483179005871	active site 2 [active]
483179005872	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
483179005873	metal binding site 2 [ion binding]; metal-binding site
483179005874	putative DNA binding helix; other site
483179005875	metal binding site 1 [ion binding]; metal-binding site
483179005876	dimer interface [polypeptide binding]; other site
483179005877	structural Zn2+ binding site [ion binding]; other site
483179005878	NMT1-like family; Region: NMT1_2; cl15260
483179005879	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
483179005880	Bacterial SH3 domain; Region: SH3_3; cl02551
483179005881	Bacterial SH3 domain; Region: SH3_3; cl02551
483179005882	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
483179005883	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179005884	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
483179005885	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179005886	NlpC/P60 family; Region: NLPC_P60; cl11438
483179005887	Helix-turn-helix domains; Region: HTH; cl00088
483179005888	multifunctional aminopeptidase A; Provisional; Region: PRK00913
483179005889	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
483179005890	interface (dimer of trimers) [polypeptide binding]; other site
483179005891	Substrate-binding/catalytic site; other site
483179005892	Zn-binding sites [ion binding]; other site
483179005893	Flp/Fap pilin component; Region: Flp_Fap; cl01585
483179005894	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
483179005895	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
483179005896	DNA binding site [nucleotide binding]
483179005897	catalytic residue [active]
483179005898	H2TH interface [polypeptide binding]; other site
483179005899	putative catalytic residues [active]
483179005900	turnover-facilitating residue; other site
483179005901	intercalation triad [nucleotide binding]; other site
483179005902	8OG recognition residue [nucleotide binding]; other site
483179005903	putative reading head residues; other site
483179005904	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
483179005905	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
483179005906	enoyl-CoA hydratase; Provisional; Region: PRK05862
483179005907	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
483179005908	substrate binding site [chemical binding]; other site
483179005909	oxyanion hole (OAH) forming residues; other site
483179005910	trimer interface [polypeptide binding]; other site
483179005911	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
483179005912	S-element; BCAN_B0002
483179005913	replication initiation protein RepC; Provisional; Region: PRK13824
483179005914	Helix-turn-helix domains; Region: HTH; cl00088
483179005915	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
483179005916	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
483179005917	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
483179005918	substrate binding site [chemical binding]; other site
483179005919	dimer interface [polypeptide binding]; other site
483179005920	ATP binding site [chemical binding]; other site
483179005921	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
483179005922	active site
483179005923	tetramer interface [polypeptide binding]; other site
483179005924	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
483179005925	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
483179005926	TM-ABC transporter signature motif; other site
483179005927	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
483179005928	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
483179005929	ligand binding site [chemical binding]; other site
483179005930	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
483179005931	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
483179005932	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
483179005933	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
483179005934	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
483179005935	putative NAD(P) binding site [chemical binding]; other site
483179005936	active site
483179005937	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
483179005938	hydrophobic substrate binding pocket; other site
483179005939	Isochorismatase family; Region: Isochorismatase; pfam00857
483179005940	active site
483179005941	conserved cis-peptide bond; other site
483179005942	Phosphopantetheine attachment site; Region: PP-binding; cl09936
483179005943	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
483179005944	AMP-binding enzyme; Region: AMP-binding; cl15778
483179005945	AMP-binding enzyme; Region: AMP-binding; cl15778
483179005946	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
483179005947	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
483179005948	Moco binding site; other site
483179005949	metal coordination site [ion binding]; other site
483179005950	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
483179005951	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
483179005952	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
483179005953	RNA polymerase sigma factor; Provisional; Region: PRK12539
483179005954	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
483179005955	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
483179005956	Protein of unknown function (DUF1109); Region: DUF1109; cl02071
483179005957	Transcriptional regulators [Transcription]; Region: FadR; COG2186
483179005958	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179005959	DNA-binding site [nucleotide binding]; DNA binding site
483179005960	FCD domain; Region: FCD; cl11656
483179005961	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
483179005962	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
483179005963	putative ligand binding site [chemical binding]; other site
483179005964	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
483179005965	TM-ABC transporter signature motif; other site
483179005966	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
483179005967	TM-ABC transporter signature motif; other site
483179005968	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
483179005969	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
483179005970	Walker A/P-loop; other site
483179005971	ATP binding site [chemical binding]; other site
483179005972	Q-loop/lid; other site
483179005973	ABC transporter signature motif; other site
483179005974	Walker B; other site
483179005975	D-loop; other site
483179005976	H-loop/switch region; other site
483179005977	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
483179005978	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179005979	active site
483179005980	metal binding site [ion binding]; metal-binding site
483179005981	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
483179005982	classical (c) SDRs; Region: SDR_c; cd05233
483179005983	NAD(P) binding site [chemical binding]; other site
483179005984	active site
483179005985	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
483179005986	classical (c) SDRs; Region: SDR_c; cd05233
483179005987	NAD(P) binding site [chemical binding]; other site
483179005988	active site
483179005989	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
483179005990	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
483179005991	tetramer interface [polypeptide binding]; other site
483179005992	TPP-binding site [chemical binding]; other site
483179005993	heterodimer interface [polypeptide binding]; other site
483179005994	phosphorylation loop region [posttranslational modification]
483179005995	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
483179005996	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
483179005997	alpha subunit interface [polypeptide binding]; other site
483179005998	TPP binding site [chemical binding]; other site
483179005999	heterodimer interface [polypeptide binding]; other site
483179006000	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
483179006001	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
483179006002	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
483179006003	E3 interaction surface; other site
483179006004	lipoyl attachment site [posttranslational modification]; other site
483179006005	e3 binding domain; Region: E3_binding; pfam02817
483179006006	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
483179006007	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
483179006008	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
483179006009	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
483179006010	shikimate binding site; other site
483179006011	NAD(P) binding site [chemical binding]; other site
483179006012	magnesium-transporting ATPase; Provisional; Region: PRK15122
483179006013	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
483179006014	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
483179006015	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179006016	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
483179006017	magnesium transport protein MgtC; Provisional; Region: PRK15385
483179006018	MgtC family; Region: MgtC; pfam02308
483179006019	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
483179006020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179006021	ATP binding site [chemical binding]; other site
483179006022	Mg2+ binding site [ion binding]; other site
483179006023	G-X-G motif; other site
483179006024	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
483179006025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179006026	active site
483179006027	phosphorylation site [posttranslational modification]
483179006028	intermolecular recognition site; other site
483179006029	dimerization interface [polypeptide binding]; other site
483179006030	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
483179006031	dimerization interface [polypeptide binding]; other site
483179006032	DNA binding residues [nucleotide binding]
483179006033	Response regulator receiver domain; Region: Response_reg; pfam00072
483179006034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179006035	active site
483179006036	phosphorylation site [posttranslational modification]
483179006037	intermolecular recognition site; other site
483179006038	dimerization interface [polypeptide binding]; other site
483179006039	N-formylglutamate amidohydrolase; Region: FGase; cl01522
483179006040	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
483179006041	active site
483179006042	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
483179006043	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179006044	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
483179006045	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
483179006046	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
483179006047	putative dimer interface [polypeptide binding]; other site
483179006048	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
483179006049	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
483179006050	tetramer interface [polypeptide binding]; other site
483179006051	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179006052	catalytic residue [active]
483179006053	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
483179006054	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
483179006055	active site
483179006056	dimer interface [polypeptide binding]; other site
483179006057	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
483179006058	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
483179006059	active site
483179006060	FMN binding site [chemical binding]; other site
483179006061	substrate binding site [chemical binding]; other site
483179006062	3Fe-4S cluster binding site [ion binding]; other site
483179006063	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
483179006064	domain interface; other site
483179006065	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
483179006066	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
483179006067	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
483179006068	active site
483179006069	catalytic triad [active]
483179006070	oxyanion hole [active]
483179006071	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
483179006072	ligand binding site [chemical binding]; other site
483179006073	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
483179006074	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
483179006075	Walker A motif; other site
483179006076	hexamer interface [polypeptide binding]; other site
483179006077	ATP binding site [chemical binding]; other site
483179006078	Walker B motif; other site
483179006079	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
483179006080	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
483179006081	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
483179006082	VirB7 interaction site; other site
483179006083	VirB8 protein; Region: VirB8; cl01500
483179006084	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
483179006085	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
483179006086	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
483179006087	Type IV secretion system proteins; Region: T4SS; pfam07996
483179006088	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
483179006089	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
483179006090	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
483179006091	TrbC/VIRB2 family; Region: TrbC; cl01583
483179006092	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
483179006093	N-acetyl-D-glucosamine binding site [chemical binding]; other site
483179006094	catalytic residue [active]
483179006095	lytic murein transglycosylase; Region: MltB_2; TIGR02283
483179006096	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
483179006097	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
483179006098	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
483179006099	active site
483179006100	tetramer interface; other site
483179006101	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179006102	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
483179006103	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
483179006104	putative active site [active]
483179006105	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
483179006106	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
483179006107	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
483179006108	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
483179006109	ferrochelatase; Reviewed; Region: hemH; PRK00035
483179006110	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
483179006111	C-terminal domain interface [polypeptide binding]; other site
483179006112	active site
483179006113	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
483179006114	active site
483179006115	N-terminal domain interface [polypeptide binding]; other site
483179006116	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
483179006117	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
483179006118	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
483179006119	substrate-cofactor binding pocket; other site
483179006120	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179006121	homodimer interface [polypeptide binding]; other site
483179006122	catalytic residue [active]
483179006123	aminodeoxychorismate synthase; Provisional; Region: PRK07508
483179006124	chorismate binding enzyme; Region: Chorismate_bind; cl10555
483179006125	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
483179006126	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
483179006127	active site
483179006128	Zn binding site [ion binding]; other site
483179006129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
483179006130	Peptidase M15; Region: Peptidase_M15_3; cl01194
483179006131	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
483179006132	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
483179006133	active site
483179006134	intersubunit interface [polypeptide binding]; other site
483179006135	catalytic residue [active]
483179006136	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
483179006137	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
483179006138	active site residue [active]
483179006139	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179006140	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
483179006141	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006142	dimer interface [polypeptide binding]; other site
483179006143	conserved gate region; other site
483179006144	putative PBP binding loops; other site
483179006145	ABC-ATPase subunit interface; other site
483179006146	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
483179006147	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179006148	Walker A/P-loop; other site
483179006149	ATP binding site [chemical binding]; other site
483179006150	Q-loop/lid; other site
483179006151	ABC transporter signature motif; other site
483179006152	Walker B; other site
483179006153	D-loop; other site
483179006154	H-loop/switch region; other site
483179006155	TOBE domain; Region: TOBE_2; cl01440
483179006156	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
483179006157	High-affinity nickel-transport protein; Region: NicO; cl00964
483179006158	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
483179006159	Helix-turn-helix domains; Region: HTH; cl00088
483179006160	LysR family transcriptional regulator; Provisional; Region: PRK14997
483179006161	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
483179006162	putative effector binding pocket; other site
483179006163	dimerization interface [polypeptide binding]; other site
483179006164	Amidase; Region: Amidase; cl11426
483179006165	speF leader; BCAN_B0103
483179006166	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
483179006167	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
483179006168	dimer interface [polypeptide binding]; other site
483179006169	active site
483179006170	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
483179006171	catalytic residues [active]
483179006172	substrate binding site [chemical binding]; other site
483179006173	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
483179006174	Chain length determinant protein; Region: Wzz; cl15801
483179006175	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
483179006176	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
483179006177	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
483179006178	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
483179006179	active site
483179006180	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
483179006181	O-Antigen ligase; Region: Wzy_C; cl04850
483179006182	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179006183	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006184	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179006185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006186	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
483179006187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006188	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
483179006189	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
483179006190	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
483179006191	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179006192	Walker A/P-loop; other site
483179006193	ATP binding site [chemical binding]; other site
483179006194	Q-loop/lid; other site
483179006195	ABC transporter signature motif; other site
483179006196	Walker B; other site
483179006197	D-loop; other site
483179006198	H-loop/switch region; other site
483179006199	TOBE domain; Region: TOBE_2; cl01440
483179006200	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
483179006201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006202	dimer interface [polypeptide binding]; other site
483179006203	conserved gate region; other site
483179006204	putative PBP binding loops; other site
483179006205	ABC-ATPase subunit interface; other site
483179006206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006207	dimer interface [polypeptide binding]; other site
483179006208	conserved gate region; other site
483179006209	putative PBP binding loops; other site
483179006210	ABC-ATPase subunit interface; other site
483179006211	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
483179006212	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179006213	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
483179006214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179006215	putative substrate translocation pore; other site
483179006216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179006217	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
483179006218	Helix-turn-helix domains; Region: HTH; cl00088
483179006219	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
483179006220	Autoinducer binding domain; Region: Autoind_bind; pfam03472
483179006221	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
483179006222	DNA binding residues [nucleotide binding]
483179006223	dimerization interface [polypeptide binding]; other site
483179006224	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
483179006225	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
483179006226	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
483179006227	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
483179006228	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
483179006229	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
483179006230	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
483179006231	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
483179006232	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
483179006233	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
483179006234	Flagella basal body rod protein; Region: Flg_bb_rod; cl16922
483179006235	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
483179006236	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
483179006237	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179006238	Walker A motif; other site
483179006239	ATP binding site [chemical binding]; other site
483179006240	Walker B motif; other site
483179006241	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
483179006242	active site
483179006243	GtrA-like protein; Region: GtrA; cl00971
483179006244	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
483179006245	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
483179006246	Ligand binding site; other site
483179006247	Putative Catalytic site; other site
483179006248	DXD motif; other site
483179006249	Peptidase family M48; Region: Peptidase_M48; cl12018
483179006250	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
483179006251	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
483179006252	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
483179006253	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
483179006254	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179006255	Helix-turn-helix domains; Region: HTH; cl00088
483179006256	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
483179006257	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179006258	putative substrate translocation pore; other site
483179006259	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
483179006260	intersubunit interface [polypeptide binding]; other site
483179006261	active site
483179006262	Zn2+ binding site [ion binding]; other site
483179006263	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
483179006264	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
483179006265	putative NAD(P) binding site [chemical binding]; other site
483179006266	active site
483179006267	putative substrate binding site [chemical binding]; other site
483179006268	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
483179006269	Helix-turn-helix domains; Region: HTH; cl00088
483179006270	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
483179006271	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
483179006272	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
483179006273	Metal-binding active site; metal-binding site
483179006274	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
483179006275	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
483179006276	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
483179006277	Flagella basal body rod protein; Region: Flg_bb_rod; cl16922
483179006278	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
483179006279	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
483179006280	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
483179006281	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
483179006282	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
483179006283	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
483179006284	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
483179006285	MgtE intracellular N domain; Region: MgtE_N; cl15244
483179006286	Flagellar L-ring protein; Region: FlgH; cl00905
483179006287	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
483179006288	FliP family; Region: FliP; cl00593
483179006289	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
483179006290	Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042
483179006291	Transcriptional regulator [Transcription]; Region: LysR; COG0583
483179006292	Helix-turn-helix domains; Region: HTH; cl00088
483179006293	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
483179006294	putative dimerization interface [polypeptide binding]; other site
483179006295	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
483179006296	CoA-transferase family III; Region: CoA_transf_3; pfam02515
483179006297	Uncharacterized conserved protein [Function unknown]; Region: COG3777
483179006298	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
483179006299	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
483179006300	active site 2 [active]
483179006301	active site 1 [active]
483179006302	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
483179006303	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
483179006304	Cytochrome c; Region: Cytochrom_C; cl11414
483179006305	Protein of unknown function (DUF465); Region: DUF465; cl01070
483179006306	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
483179006307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179006308	DNA-binding site [nucleotide binding]; DNA binding site
483179006309	FCD domain; Region: FCD; cl11656
483179006310	Helix-turn-helix domains; Region: HTH; cl00088
483179006311	transcriptional activator TtdR; Provisional; Region: PRK09801
483179006312	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
483179006313	putative effector binding pocket; other site
483179006314	dimerization interface [polypeptide binding]; other site
483179006315	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
483179006316	FAD binding domain; Region: FAD_binding_4; pfam01565
483179006317	FAD binding domain; Region: FAD_binding_4; pfam01565
483179006318	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
483179006319	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
483179006320	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
483179006321	Cysteine-rich domain; Region: CCG; pfam02754
483179006322	Cysteine-rich domain; Region: CCG; pfam02754
483179006323	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
483179006324	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
483179006325	active site
483179006326	catalytic tetrad [active]
483179006327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
483179006328	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
483179006329	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
483179006330	LysE type translocator; Region: LysE; cl00565
483179006331	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
483179006332	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
483179006333	dimer interface [polypeptide binding]; other site
483179006334	motif 1; other site
483179006335	motif 2; other site
483179006336	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
483179006337	active site
483179006338	motif 3; other site
483179006339	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
483179006340	anticodon binding site; other site
483179006341	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
483179006342	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
483179006343	motif 1; other site
483179006344	dimer interface [polypeptide binding]; other site
483179006345	active site
483179006346	motif 2; other site
483179006347	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
483179006348	active site
483179006349	motif 3; other site
483179006350	ATP phosphoribosyltransferase; Region: HisG; cl15266
483179006351	DoxX; Region: DoxX; cl00976
483179006352	fumarate hydratase; Reviewed; Region: fumC; PRK00485
483179006353	Class II fumarases; Region: Fumarase_classII; cd01362
483179006354	active site
483179006355	tetramer interface [polypeptide binding]; other site
483179006356	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
483179006357	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
483179006358	ring oligomerisation interface [polypeptide binding]; other site
483179006359	ATP/Mg binding site [chemical binding]; other site
483179006360	stacking interactions; other site
483179006361	hinge regions; other site
483179006362	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
483179006363	oligomerisation interface [polypeptide binding]; other site
483179006364	mobile loop; other site
483179006365	roof hairpin; other site
483179006366	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
483179006367	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179006368	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179006369	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
483179006370	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
483179006371	active site
483179006372	Riboflavin kinase; Region: Flavokinase; cl03312
483179006373	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
483179006374	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
483179006375	active site
483179006376	HIGH motif; other site
483179006377	nucleotide binding site [chemical binding]; other site
483179006378	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
483179006379	active site
483179006380	KMSKS motif; other site
483179006381	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
483179006382	tRNA binding surface [nucleotide binding]; other site
483179006383	anticodon binding site; other site
483179006384	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
483179006385	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
483179006386	nucleoside/Zn binding site; other site
483179006387	dimer interface [polypeptide binding]; other site
483179006388	catalytic motif [active]
483179006389	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
483179006390	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
483179006391	RNA binding surface [nucleotide binding]; other site
483179006392	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
483179006393	active site
483179006394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179006395	S-adenosylmethionine binding site [chemical binding]; other site
483179006396	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
483179006397	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
483179006398	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
483179006399	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
483179006400	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
483179006401	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
483179006402	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
483179006403	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006404	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
483179006405	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
483179006406	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
483179006407	active site
483179006408	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
483179006409	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
483179006410	putative acyl-acceptor binding pocket; other site
483179006411	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
483179006412	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
483179006413	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
483179006414	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
483179006415	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
483179006416	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535
483179006417	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
483179006418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179006419	ATP binding site [chemical binding]; other site
483179006420	Mg2+ binding site [ion binding]; other site
483179006421	G-X-G motif; other site
483179006422	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
483179006423	ATP binding site [chemical binding]; other site
483179006424	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
483179006425	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
483179006426	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
483179006427	active site
483179006428	Transcriptional regulator [Transcription]; Region: IclR; COG1414
483179006429	Helix-turn-helix domains; Region: HTH; cl00088
483179006430	Bacterial transcriptional regulator; Region: IclR; pfam01614
483179006431	enoyl-CoA hydratase; Provisional; Region: PRK08138
483179006432	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
483179006433	substrate binding site [chemical binding]; other site
483179006434	oxyanion hole (OAH) forming residues; other site
483179006435	trimer interface [polypeptide binding]; other site
483179006436	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
483179006437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006438	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
483179006439	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
483179006440	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
483179006441	CoA-transferase family III; Region: CoA_transf_3; pfam02515
483179006442	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
483179006443	putative active site [active]
483179006444	putative FMN binding site [chemical binding]; other site
483179006445	putative substrate binding site [chemical binding]; other site
483179006446	putative catalytic residue [active]
483179006447	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786
483179006448	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
483179006449	DNA binding residues [nucleotide binding]
483179006450	putative dimer interface [polypeptide binding]; other site
483179006451	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
483179006452	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
483179006453	potential catalytic triad [active]
483179006454	conserved cys residue [active]
483179006455	sensor protein QseC; Provisional; Region: PRK10337
483179006456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
483179006457	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179006458	dimer interface [polypeptide binding]; other site
483179006459	phosphorylation site [posttranslational modification]
483179006460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
483179006461	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179006462	DNA binding site [nucleotide binding]
483179006463	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
483179006464	FlgD Ig-like domain; Region: FlgD_ig; cl15790
483179006465	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
483179006466	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
483179006467	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
483179006468	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
483179006469	FAD binding pocket [chemical binding]; other site
483179006470	FAD binding motif [chemical binding]; other site
483179006471	catalytic residues [active]
483179006472	NAD binding pocket [chemical binding]; other site
483179006473	phosphate binding motif [ion binding]; other site
483179006474	beta-alpha-beta structure motif; other site
483179006475	ApbE family; Region: ApbE; cl00643
483179006476	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
483179006477	GAF domain; Region: GAF; cl15785
483179006478	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179006479	metal binding site [ion binding]; metal-binding site
483179006480	active site
483179006481	I-site; other site
483179006482	EamA-like transporter family; Region: EamA; cl01037
483179006483	EamA-like transporter family; Region: EamA; cl01037
483179006484	Transcriptional regulators [Transcription]; Region: GntR; COG1802
483179006485	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179006486	DNA-binding site [nucleotide binding]; DNA binding site
483179006487	FCD domain; Region: FCD; cl11656
483179006488	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
483179006489	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
483179006490	inhibitor site; inhibition site
483179006491	active site
483179006492	dimer interface [polypeptide binding]; other site
483179006493	catalytic residue [active]
483179006494	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
483179006495	MatE; Region: MatE; cl10513
483179006496	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
483179006497	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
483179006498	Cytochrome c; Region: Cytochrom_C; cl11414
483179006499	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
483179006500	D-pathway; other site
483179006501	K-pathway; other site
483179006502	Binuclear center (active site) [active]
483179006503	Putative proton exit pathway; other site
483179006504	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179006505	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
483179006506	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
483179006507	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
483179006508	metal ion-dependent adhesion site (MIDAS); other site
483179006509	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
483179006510	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
483179006511	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
483179006512	CPxP  motif; other site
483179006513	Domain of unknown function DUF59; Region: DUF59; cl00941
483179006514	Phospholipid methyltransferase; Region: PEMT; cl00763
483179006515	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
483179006516	nucleophilic elbow; other site
483179006517	catalytic triad; other site
483179006518	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
483179006519	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179006520	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179006521	Uncharacterized conserved protein [Function unknown]; Region: COG1262
483179006522	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
483179006523	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
483179006524	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
483179006525	ligand binding site [chemical binding]; other site
483179006526	flexible hinge region; other site
483179006527	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
483179006528	putative switch regulator; other site
483179006529	non-specific DNA interactions [nucleotide binding]; other site
483179006530	DNA binding site [nucleotide binding]
483179006531	sequence specific DNA binding site [nucleotide binding]; other site
483179006532	putative cAMP binding site [chemical binding]; other site
483179006533	Transcriptional regulators [Transcription]; Region: PurR; COG1609
483179006534	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
483179006535	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
483179006536	dimerization interface [polypeptide binding]; other site
483179006537	ligand binding site [chemical binding]; other site
483179006538	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
483179006539	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
483179006540	putative ligand binding site [chemical binding]; other site
483179006541	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
483179006542	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179006543	Walker A/P-loop; other site
483179006544	ATP binding site [chemical binding]; other site
483179006545	Q-loop/lid; other site
483179006546	ABC transporter signature motif; other site
483179006547	Walker B; other site
483179006548	D-loop; other site
483179006549	H-loop/switch region; other site
483179006550	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179006551	TM-ABC transporter signature motif; other site
483179006552	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
483179006553	classical (c) SDRs; Region: SDR_c; cd05233
483179006554	NAD(P) binding site [chemical binding]; other site
483179006555	active site
483179006556	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
483179006557	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
483179006558	N- and C-terminal domain interface [polypeptide binding]; other site
483179006559	putative active site [active]
483179006560	putative MgATP binding site [chemical binding]; other site
483179006561	catalytic site [active]
483179006562	metal binding site [ion binding]; metal-binding site
483179006563	carbohydrate binding site [chemical binding]; other site
483179006564	putative homodimer interface [polypeptide binding]; other site
483179006565	RES domain; Region: RES; cl02411
483179006566	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
483179006567	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
483179006568	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179006569	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
483179006570	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
483179006571	FMN-binding domain; Region: FMN_bind; cl01081
483179006572	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
483179006573	4Fe-4S binding domain; Region: Fer4_5; pfam12801
483179006574	4Fe-4S binding domain; Region: Fer4_5; pfam12801
483179006575	nitrous-oxide reductase; Validated; Region: PRK02888
483179006576	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179006577	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
483179006578	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
483179006579	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179006580	Walker A/P-loop; other site
483179006581	ATP binding site [chemical binding]; other site
483179006582	Q-loop/lid; other site
483179006583	ABC transporter signature motif; other site
483179006584	Walker B; other site
483179006585	D-loop; other site
483179006586	H-loop/switch region; other site
483179006587	ABC-2 type transporter; Region: ABC2_membrane; cl11417
483179006588	NosL; Region: NosL; cl01769
483179006589	ApbE family; Region: ApbE; cl00643
483179006590	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
483179006591	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
483179006592	ligand binding site [chemical binding]; other site
483179006593	flexible hinge region; other site
483179006594	Helix-turn-helix domains; Region: HTH; cl00088
483179006595	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179006596	NnrS protein; Region: NnrS; cl01258
483179006597	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
483179006598	NMT1-like family; Region: NMT1_2; cl15260
483179006599	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
483179006600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006601	dimer interface [polypeptide binding]; other site
483179006602	conserved gate region; other site
483179006603	putative PBP binding loops; other site
483179006604	ABC-ATPase subunit interface; other site
483179006605	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
483179006606	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
483179006607	Walker A/P-loop; other site
483179006608	ATP binding site [chemical binding]; other site
483179006609	Q-loop/lid; other site
483179006610	ABC transporter signature motif; other site
483179006611	Walker B; other site
483179006612	D-loop; other site
483179006613	H-loop/switch region; other site
483179006614	Peptidase family U32; Region: Peptidase_U32; cl03113
483179006615	Peptidase family U32; Region: Peptidase_U32; cl03113
483179006616	SCP-2 sterol transfer family; Region: SCP2; cl01225
483179006617	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
483179006618	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
483179006619	Flavoprotein; Region: Flavoprotein; cl08021
483179006620	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179006621	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
483179006622	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
483179006623	nitrate reductase, beta subunit; Region: narH; TIGR01660
483179006624	4Fe-4S binding domain; Region: Fer4; cl02805
483179006625	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
483179006626	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
483179006627	[4Fe-4S] binding site [ion binding]; other site
483179006628	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
483179006629	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
483179006630	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
483179006631	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
483179006632	molybdopterin cofactor binding site; other site
483179006633	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
483179006634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179006635	putative substrate translocation pore; other site
483179006636	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
483179006637	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
483179006638	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
483179006639	ligand binding site [chemical binding]; other site
483179006640	flexible hinge region; other site
483179006641	Helix-turn-helix domains; Region: HTH; cl00088
483179006642	Transcriptional regulators [Transcription]; Region: PurR; COG1609
483179006643	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
483179006644	DNA binding site [nucleotide binding]
483179006645	domain linker motif; other site
483179006646	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
483179006647	ligand binding site [chemical binding]; other site
483179006648	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
483179006649	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179006650	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
483179006651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006652	dimer interface [polypeptide binding]; other site
483179006653	conserved gate region; other site
483179006654	putative PBP binding loops; other site
483179006655	ABC-ATPase subunit interface; other site
483179006656	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
483179006657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006658	dimer interface [polypeptide binding]; other site
483179006659	conserved gate region; other site
483179006660	putative PBP binding loops; other site
483179006661	ABC-ATPase subunit interface; other site
483179006662	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
483179006663	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
483179006664	Walker A/P-loop; other site
483179006665	ATP binding site [chemical binding]; other site
483179006666	Q-loop/lid; other site
483179006667	ABC transporter signature motif; other site
483179006668	Walker B; other site
483179006669	D-loop; other site
483179006670	H-loop/switch region; other site
483179006671	TOBE domain; Region: TOBE_2; cl01440
483179006672	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
483179006673	conserved cys residue [active]
483179006674	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179006675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006676	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
483179006677	Transmembrane secretion effector; Region: MFS_3; pfam05977
483179006678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179006679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179006680	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
483179006681	catalytic residues [active]
483179006682	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
483179006683	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
483179006684	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
483179006685	Class I ribonucleotide reductase; Region: RNR_I; cd01679
483179006686	active site
483179006687	dimer interface [polypeptide binding]; other site
483179006688	catalytic residues [active]
483179006689	effector binding site; other site
483179006690	R2 peptide binding site; other site
483179006691	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
483179006692	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
483179006693	dimer interface [polypeptide binding]; other site
483179006694	putative radical transfer pathway; other site
483179006695	diiron center [ion binding]; other site
483179006696	tyrosyl radical; other site
483179006697	septum formation inhibitor; Reviewed; Region: minC; PRK05177
483179006698	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
483179006699	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
483179006700	Switch I; other site
483179006701	Switch II; other site
483179006702	Septum formation topological specificity factor MinE; Region: MinE; cl00538
483179006703	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
483179006704	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
483179006705	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179006706	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
483179006707	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
483179006708	Walker A/P-loop; other site
483179006709	ATP binding site [chemical binding]; other site
483179006710	Q-loop/lid; other site
483179006711	ABC transporter signature motif; other site
483179006712	Walker B; other site
483179006713	D-loop; other site
483179006714	H-loop/switch region; other site
483179006715	TOBE domain; Region: TOBE_2; cl01440
483179006716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006717	dimer interface [polypeptide binding]; other site
483179006718	conserved gate region; other site
483179006719	putative PBP binding loops; other site
483179006720	ABC-ATPase subunit interface; other site
483179006721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006722	dimer interface [polypeptide binding]; other site
483179006723	conserved gate region; other site
483179006724	putative PBP binding loops; other site
483179006725	ABC-ATPase subunit interface; other site
483179006726	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
483179006727	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
483179006728	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
483179006729	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179006730	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179006731	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
483179006732	Glutaminase; Region: Glutaminase; cl00907
483179006733	HdeA/HdeB family; Region: HdeA; cl05752
483179006734	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
483179006735	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
483179006736	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
483179006737	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
483179006738	Helix-turn-helix domains; Region: HTH; cl00088
483179006739	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179006740	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
483179006741	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
483179006742	Substrate binding site; other site
483179006743	Cupin domain; Region: Cupin_2; cl09118
483179006744	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
483179006745	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
483179006746	active site
483179006747	substrate binding site [chemical binding]; other site
483179006748	metal binding site [ion binding]; metal-binding site
483179006749	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
483179006750	putative active site pocket [active]
483179006751	cleavage site
483179006752	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
483179006753	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
483179006754	putative ion selectivity filter; other site
483179006755	putative pore gating glutamate residue; other site
483179006756	putative H+/Cl- coupling transport residue; other site
483179006757	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
483179006758	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
483179006759	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
483179006760	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
483179006761	active site
483179006762	Cytochrome c [Energy production and conversion]; Region: COG3258
483179006763	Cytochrome c; Region: Cytochrom_C; cl11414
483179006764	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
483179006765	Helix-turn-helix domains; Region: HTH; cl00088
483179006766	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
483179006767	dimerization interface [polypeptide binding]; other site
483179006768	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
483179006769	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
483179006770	tetramer interface [polypeptide binding]; other site
483179006771	heme binding pocket [chemical binding]; other site
483179006772	NADPH binding site [chemical binding]; other site
483179006773	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
483179006774	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
483179006775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179006776	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
483179006777	CoenzymeA binding site [chemical binding]; other site
483179006778	subunit interaction site [polypeptide binding]; other site
483179006779	PHB binding site; other site
483179006780	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
483179006781	GMP synthase; Reviewed; Region: guaA; PRK00074
483179006782	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
483179006783	AMP/PPi binding site [chemical binding]; other site
483179006784	candidate oxyanion hole; other site
483179006785	catalytic triad [active]
483179006786	potential glutamine specificity residues [chemical binding]; other site
483179006787	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
483179006788	ATP Binding subdomain [chemical binding]; other site
483179006789	Ligand Binding sites [chemical binding]; other site
483179006790	Dimerization subdomain; other site
483179006791	integrase; Provisional; Region: PRK09692
483179006792	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
483179006793	active site
483179006794	Int/Topo IB signature motif; other site
483179006795	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
483179006796	Replication initiator protein A; Region: RPA; cl02339
483179006797	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
483179006798	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
483179006799	TraC-like protein; Region: TraC; cl06725
483179006800	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
483179006801	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
483179006802	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
483179006803	Predicted ATPase [General function prediction only]; Region: COG5293
483179006804	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
483179006805	RelB antitoxin; Region: RelB; cl01171
483179006806	Fe2+ transport protein; Region: Iron_transport; cl01377
483179006807	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179006808	Iron permease FTR1 family; Region: FTR1; cl00475
483179006809	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
483179006810	4Fe-4S binding domain; Region: Fer4_5; pfam12801
483179006811	putative phosphoketolase; Provisional; Region: PRK05261
483179006812	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
483179006813	TPP-binding site; other site
483179006814	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
483179006815	XFP C-terminal domain; Region: XFP_C; pfam09363
483179006816	Acetokinase family; Region: Acetate_kinase; cl01029
483179006817	acetate kinase; Region: ackA; TIGR00016
483179006818	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
483179006819	Transcriptional regulators [Transcription]; Region: GntR; COG1802
483179006820	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179006821	DNA-binding site [nucleotide binding]; DNA binding site
483179006822	FCD domain; Region: FCD; cl11656
483179006823	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
483179006824	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
483179006825	NAD(P) binding site [chemical binding]; other site
483179006826	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
483179006827	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
483179006828	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
483179006829	TM-ABC transporter signature motif; other site
483179006830	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
483179006831	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
483179006832	Walker A/P-loop; other site
483179006833	ATP binding site [chemical binding]; other site
483179006834	Q-loop/lid; other site
483179006835	ABC transporter signature motif; other site
483179006836	Walker B; other site
483179006837	D-loop; other site
483179006838	H-loop/switch region; other site
483179006839	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
483179006840	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006841	NAD(P) binding site [chemical binding]; other site
483179006842	active site
483179006843	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
483179006844	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
483179006845	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
483179006846	shikimate binding site; other site
483179006847	NAD(P) binding site [chemical binding]; other site
483179006848	choline dehydrogenase; Validated; Region: PRK02106
483179006849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006850	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
483179006851	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179006852	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
483179006853	tetramerization interface [polypeptide binding]; other site
483179006854	NAD(P) binding site [chemical binding]; other site
483179006855	catalytic residues [active]
483179006856	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
483179006857	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
483179006858	NAD binding site [chemical binding]; other site
483179006859	catalytic Zn binding site [ion binding]; other site
483179006860	substrate binding site [chemical binding]; other site
483179006861	structural Zn binding site [ion binding]; other site
483179006862	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179006863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179006865	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179006866	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
483179006867	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179006868	Walker A/P-loop; other site
483179006869	ATP binding site [chemical binding]; other site
483179006870	Q-loop/lid; other site
483179006871	ABC transporter signature motif; other site
483179006872	Walker B; other site
483179006873	D-loop; other site
483179006874	H-loop/switch region; other site
483179006875	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179006876	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
483179006877	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179006878	Walker A/P-loop; other site
483179006879	ATP binding site [chemical binding]; other site
483179006880	Q-loop/lid; other site
483179006881	ABC transporter signature motif; other site
483179006882	Walker B; other site
483179006883	D-loop; other site
483179006884	H-loop/switch region; other site
483179006885	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179006886	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
483179006887	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
483179006888	inhibitor site; inhibition site
483179006889	active site
483179006890	dimer interface [polypeptide binding]; other site
483179006891	catalytic residue [active]
483179006892	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
483179006893	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006894	dimer interface [polypeptide binding]; other site
483179006895	conserved gate region; other site
483179006896	putative PBP binding loops; other site
483179006897	ABC-ATPase subunit interface; other site
483179006898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179006899	dimer interface [polypeptide binding]; other site
483179006900	conserved gate region; other site
483179006901	putative PBP binding loops; other site
483179006902	ABC-ATPase subunit interface; other site
483179006903	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
483179006904	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
483179006905	Transcriptional regulators [Transcription]; Region: FadR; COG2186
483179006906	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179006907	DNA-binding site [nucleotide binding]; DNA binding site
483179006908	FCD domain; Region: FCD; cl11656
483179006909	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
483179006910	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
483179006911	putative active site cavity [active]
483179006912	N-acetylmannosamine kinase; Provisional; Region: PRK05082
483179006913	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
483179006914	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
483179006915	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
483179006916	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
483179006917	ligand binding site [chemical binding]; other site
483179006918	flexible hinge region; other site
483179006919	Helix-turn-helix domains; Region: HTH; cl00088
483179006920	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
483179006921	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
483179006922	DNA binding residues [nucleotide binding]
483179006923	dimerization interface [polypeptide binding]; other site
483179006924	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
483179006925	Chain length determinant protein; Region: Wzz; cl15801
483179006926	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
483179006927	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179006928	G3 box; other site
483179006929	Switch II region; other site
483179006930	G4 box; other site
483179006931	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
483179006932	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
483179006933	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
483179006934	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
483179006935	NADP binding site [chemical binding]; other site
483179006936	active site
483179006937	putative substrate binding site [chemical binding]; other site
483179006938	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
483179006939	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
483179006940	NADP-binding site; other site
483179006941	homotetramer interface [polypeptide binding]; other site
483179006942	substrate binding site [chemical binding]; other site
483179006943	homodimer interface [polypeptide binding]; other site
483179006944	active site
483179006945	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
483179006946	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
483179006947	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
483179006948	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
483179006949	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
483179006950	putative ADP-binding pocket [chemical binding]; other site
483179006951	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179006952	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
483179006953	putative trimer interface [polypeptide binding]; other site
483179006954	putative active site [active]
483179006955	putative substrate binding site [chemical binding]; other site
483179006956	putative CoA binding site [chemical binding]; other site
483179006957	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
483179006958	putative active site [active]
483179006959	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
483179006960	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
483179006961	putative metal binding site; other site
483179006962	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
483179006963	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
483179006964	Mg++ binding site [ion binding]; other site
483179006965	putative catalytic motif [active]
483179006966	substrate binding site [chemical binding]; other site
483179006967	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
483179006968	MatE; Region: MatE; cl10513
483179006969	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
483179006970	active site
483179006971	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
483179006972	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
483179006973	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
483179006974	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
483179006975	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
483179006976	catalytic residue [active]
483179006977	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
483179006978	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
483179006979	extended (e) SDRs; Region: SDR_e; cd08946
483179006980	NAD(P) binding site [chemical binding]; other site
483179006981	active site
483179006982	substrate binding site [chemical binding]; other site
483179006983	Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310
483179006984	M28 Zn-Peptidases; Region: M28_like_3; cd05644
483179006985	active site
483179006986	metal binding site [ion binding]; metal-binding site
483179006987	Cupin domain; Region: Cupin_2; cl09118
483179006988	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
483179006989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179006990	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
483179006991	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
483179006992	active site
483179006993	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
483179006994	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
483179006995	glycerol kinase; Provisional; Region: glpK; PRK00047
483179006996	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
483179006997	N- and C-terminal domain interface [polypeptide binding]; other site
483179006998	active site
483179006999	MgATP binding site [chemical binding]; other site
483179007000	catalytic site [active]
483179007001	metal binding site [ion binding]; metal-binding site
483179007002	glycerol binding site [chemical binding]; other site
483179007003	homotetramer interface [polypeptide binding]; other site
483179007004	homodimer interface [polypeptide binding]; other site
483179007005	FBP binding site [chemical binding]; other site
483179007006	protein IIAGlc interface [polypeptide binding]; other site
483179007007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179007008	Major Facilitator Superfamily; Region: MFS_1; pfam07690
483179007009	putative substrate translocation pore; other site
483179007010	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
483179007011	Helix-turn-helix domains; Region: HTH; cl00088
483179007012	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
483179007013	putative dimerization interface [polypeptide binding]; other site
483179007014	putative substrate binding pocket [chemical binding]; other site
483179007015	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
483179007016	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
483179007017	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
483179007018	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
483179007019	active site
483179007020	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
483179007021	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
483179007022	dimer interface [polypeptide binding]; other site
483179007023	active site
483179007024	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
483179007025	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
483179007026	NAD binding site [chemical binding]; other site
483179007027	homodimer interface [polypeptide binding]; other site
483179007028	homotetramer interface [polypeptide binding]; other site
483179007029	active site
483179007030	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
483179007031	AMP-binding enzyme; Region: AMP-binding; cl15778
483179007032	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179007033	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
483179007034	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
483179007035	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179007036	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
483179007037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007038	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
483179007039	L-serine binding site [chemical binding]; other site
483179007040	ACT domain interface; other site
483179007041	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
483179007042	active site
483179007043	catalytic residues [active]
483179007044	metal binding site [ion binding]; metal-binding site
483179007045	Protein of unknown function (DUF808); Region: DUF808; cl01002
483179007046	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179007047	dimerization interface [polypeptide binding]; other site
483179007048	putative DNA binding site [nucleotide binding]; other site
483179007049	putative Zn2+ binding site [ion binding]; other site
483179007050	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
483179007051	Predicted transporter component [General function prediction only]; Region: COG2391
483179007052	Sulphur transport; Region: Sulf_transp; cl01018
483179007053	Transcriptional regulators [Transcription]; Region: GntR; COG1802
483179007054	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179007055	DNA-binding site [nucleotide binding]; DNA binding site
483179007056	FCD domain; Region: FCD; cl11656
483179007057	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
483179007058	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
483179007059	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
483179007060	Helix-turn-helix domains; Region: HTH; cl00088
483179007061	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
483179007062	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
483179007063	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179007064	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
483179007065	ABC-2 type transporter; Region: ABC2_membrane; cl11417
483179007066	Cupin domain; Region: Cupin_2; cl09118
483179007067	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
483179007068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007069	dimer interface [polypeptide binding]; other site
483179007070	conserved gate region; other site
483179007071	putative PBP binding loops; other site
483179007072	ABC-ATPase subunit interface; other site
483179007073	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
483179007074	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
483179007075	Walker A/P-loop; other site
483179007076	ATP binding site [chemical binding]; other site
483179007077	Q-loop/lid; other site
483179007078	ABC transporter signature motif; other site
483179007079	Walker B; other site
483179007080	D-loop; other site
483179007081	H-loop/switch region; other site
483179007082	NMT1-like family; Region: NMT1_2; cl15260
483179007083	NMT1/THI5 like; Region: NMT1; pfam09084
483179007084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179007085	putative substrate translocation pore; other site
483179007086	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
483179007087	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
483179007088	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179007089	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179007090	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
483179007091	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
483179007092	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
483179007093	dimer interface [polypeptide binding]; other site
483179007094	phosphorylation site [posttranslational modification]
483179007095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179007096	ATP binding site [chemical binding]; other site
483179007097	Mg2+ binding site [ion binding]; other site
483179007098	G-X-G motif; other site
483179007099	Ycf27; Reviewed; Region: orf27; CHL00148
483179007100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179007101	active site
483179007102	phosphorylation site [posttranslational modification]
483179007103	intermolecular recognition site; other site
483179007104	dimerization interface [polypeptide binding]; other site
483179007105	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179007106	DNA binding site [nucleotide binding]
483179007107	Protein of unknown function, DUF488; Region: DUF488; cl01246
483179007108	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
483179007109	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179007110	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
483179007111	Helix-turn-helix domains; Region: HTH; cl00088
483179007112	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
483179007113	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179007114	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
483179007115	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
483179007116	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
483179007117	homoserine O-succinyltransferase; Provisional; Region: PRK05368
483179007118	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
483179007119	proposed active site lysine [active]
483179007120	conserved cys residue [active]
483179007121	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
483179007122	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
483179007123	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
483179007124	active site
483179007125	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
483179007126	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
483179007127	dimer interface [polypeptide binding]; other site
483179007128	active site
483179007129	CoA binding pocket [chemical binding]; other site
483179007130	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
483179007131	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
483179007132	inhibitor-cofactor binding pocket; inhibition site
483179007133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179007134	catalytic residue [active]
483179007135	AAA domain; Region: AAA_26; pfam13500
483179007136	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179007137	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
483179007138	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
483179007139	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
483179007140	catalytic residue [active]
483179007141	biotin synthase; Region: bioB; TIGR00433
483179007142	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179007143	FeS/SAM binding site; other site
483179007144	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
483179007145	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
483179007146	MPT binding site; other site
483179007147	trimer interface [polypeptide binding]; other site
483179007148	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
483179007149	dimer interface [polypeptide binding]; other site
483179007150	FMN binding site [chemical binding]; other site
483179007151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
483179007152	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007153	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
483179007154	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
483179007155	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
483179007156	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
483179007157	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
483179007158	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
483179007159	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
483179007160	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
483179007161	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
483179007162	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
483179007163	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
483179007164	Predicted transcriptional regulators [Transcription]; Region: COG1510
483179007165	Helix-turn-helix domains; Region: HTH; cl00088
483179007166	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
483179007167	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179007168	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228
483179007169	Walker A/P-loop; other site
483179007170	ATP binding site [chemical binding]; other site
483179007171	Q-loop/lid; other site
483179007172	ABC transporter signature motif; other site
483179007173	Walker B; other site
483179007174	D-loop; other site
483179007175	H-loop/switch region; other site
483179007176	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
483179007177	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179007178	Walker A/P-loop; other site
483179007179	ATP binding site [chemical binding]; other site
483179007180	Q-loop/lid; other site
483179007181	ABC transporter signature motif; other site
483179007182	Walker B; other site
483179007183	D-loop; other site
483179007184	H-loop/switch region; other site
483179007185	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
483179007186	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
483179007187	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
483179007188	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
483179007189	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
483179007190	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
483179007191	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179007192	DNA-binding site [nucleotide binding]; DNA binding site
483179007193	UTRA domain; Region: UTRA; cl01230
483179007194	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
483179007195	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
483179007196	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
483179007197	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179007198	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
483179007199	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007200	dimer interface [polypeptide binding]; other site
483179007201	conserved gate region; other site
483179007202	putative PBP binding loops; other site
483179007203	ABC-ATPase subunit interface; other site
483179007204	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
483179007205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007206	dimer interface [polypeptide binding]; other site
483179007207	conserved gate region; other site
483179007208	putative PBP binding loops; other site
483179007209	ABC-ATPase subunit interface; other site
483179007210	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179007211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007212	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
483179007213	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
483179007214	Walker A/P-loop; other site
483179007215	ATP binding site [chemical binding]; other site
483179007216	Q-loop/lid; other site
483179007217	ABC transporter signature motif; other site
483179007218	Walker B; other site
483179007219	D-loop; other site
483179007220	H-loop/switch region; other site
483179007221	TOBE domain; Region: TOBE_2; cl01440
483179007222	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
483179007223	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
483179007224	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
483179007225	tetramer interface [polypeptide binding]; other site
483179007226	TPP-binding site [chemical binding]; other site
483179007227	heterodimer interface [polypeptide binding]; other site
483179007228	phosphorylation loop region [posttranslational modification]
483179007229	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
483179007230	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
483179007231	alpha subunit interface [polypeptide binding]; other site
483179007232	TPP binding site [chemical binding]; other site
483179007233	heterodimer interface [polypeptide binding]; other site
483179007234	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
483179007235	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
483179007236	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
483179007237	E3 interaction surface; other site
483179007238	lipoyl attachment site [posttranslational modification]; other site
483179007239	e3 binding domain; Region: E3_binding; pfam02817
483179007240	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
483179007241	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
483179007242	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179007243	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
483179007244	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
483179007245	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179007246	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
483179007247	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
483179007248	homodimer interface [polypeptide binding]; other site
483179007249	homotetramer interface [polypeptide binding]; other site
483179007250	active site pocket [active]
483179007251	cleavage site
483179007252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179007253	putative substrate translocation pore; other site
483179007254	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
483179007255	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
483179007256	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
483179007257	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179007258	Walker A/P-loop; other site
483179007259	ATP binding site [chemical binding]; other site
483179007260	Q-loop/lid; other site
483179007261	ABC transporter signature motif; other site
483179007262	Walker B; other site
483179007263	D-loop; other site
483179007264	H-loop/switch region; other site
483179007265	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179007266	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179007267	Walker A/P-loop; other site
483179007268	ATP binding site [chemical binding]; other site
483179007269	Q-loop/lid; other site
483179007270	ABC transporter signature motif; other site
483179007271	Walker B; other site
483179007272	D-loop; other site
483179007273	H-loop/switch region; other site
483179007274	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179007275	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
483179007276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007277	dimer interface [polypeptide binding]; other site
483179007278	conserved gate region; other site
483179007279	ABC-ATPase subunit interface; other site
483179007280	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
483179007281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007282	dimer interface [polypeptide binding]; other site
483179007283	conserved gate region; other site
483179007284	putative PBP binding loops; other site
483179007285	ABC-ATPase subunit interface; other site
483179007286	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
483179007287	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
483179007288	peptide binding site [polypeptide binding]; other site
483179007289	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
483179007290	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
483179007291	peptide binding site [polypeptide binding]; other site
483179007292	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
483179007293	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
483179007294	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
483179007295	NAD binding site [chemical binding]; other site
483179007296	putative substrate binding site 2 [chemical binding]; other site
483179007297	putative substrate binding site 1 [chemical binding]; other site
483179007298	active site
483179007299	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
483179007300	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
483179007301	NAD binding site [chemical binding]; other site
483179007302	homodimer interface [polypeptide binding]; other site
483179007303	active site
483179007304	substrate binding site [chemical binding]; other site
483179007305	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
483179007306	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
483179007307	active site
483179007308	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
483179007309	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
483179007310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007311	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
483179007312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007313	Protein of unknown function (DUF995); Region: DUF995; pfam06191
483179007314	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
483179007315	Protein of unknown function (DUF995); Region: DUF995; pfam06191
483179007316	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
483179007317	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179007318	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179007319	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179007320	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
483179007321	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
483179007322	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
483179007323	Integrase core domain; Region: rve; cl01316
483179007324	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
483179007325	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
483179007326	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
483179007327	Helix-turn-helix domains; Region: HTH; cl00088
483179007328	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179007329	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
483179007330	putative deacylase active site [active]
483179007331	Helix-turn-helix domains; Region: HTH; cl00088
483179007332	Predicted transcriptional regulator [Transcription]; Region: COG1959
483179007333	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
483179007334	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
483179007335	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
483179007336	heme binding site [chemical binding]; other site
483179007337	ferroxidase pore; other site
483179007338	ferroxidase diiron center [ion binding]; other site
483179007339	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
483179007340	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
483179007341	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179007342	FeS/SAM binding site; other site
483179007343	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
483179007344	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
483179007345	putative ligand binding site [chemical binding]; other site
483179007346	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
483179007347	TM-ABC transporter signature motif; other site
483179007348	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
483179007349	TM-ABC transporter signature motif; other site
483179007350	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
483179007351	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
483179007352	Walker A/P-loop; other site
483179007353	ATP binding site [chemical binding]; other site
483179007354	Q-loop/lid; other site
483179007355	ABC transporter signature motif; other site
483179007356	Walker B; other site
483179007357	D-loop; other site
483179007358	H-loop/switch region; other site
483179007359	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
483179007360	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
483179007361	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
483179007362	NADP binding site [chemical binding]; other site
483179007363	dimer interface [polypeptide binding]; other site
483179007364	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
483179007365	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
483179007366	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
483179007367	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007368	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548
483179007369	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
483179007370	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
483179007371	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
483179007372	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
483179007373	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
483179007374	catalytic residues [active]
483179007375	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
483179007376	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179007377	active site
483179007378	metal binding site [ion binding]; metal-binding site
483179007379	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
483179007380	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
483179007381	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
483179007382	ATP binding site [chemical binding]; other site
483179007383	putative Mg++ binding site [ion binding]; other site
483179007384	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
483179007385	nucleotide binding region [chemical binding]; other site
483179007386	ATP-binding site [chemical binding]; other site
483179007387	TRCF domain; Region: TRCF; cl04088
483179007388	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
483179007389	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
483179007390	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
483179007391	generic binding surface II; other site
483179007392	ssDNA binding site; other site
483179007393	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
483179007394	ATP binding site [chemical binding]; other site
483179007395	putative Mg++ binding site [ion binding]; other site
483179007396	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
483179007397	nucleotide binding region [chemical binding]; other site
483179007398	ATP-binding site [chemical binding]; other site
483179007399	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
483179007400	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
483179007401	glutaminase active site [active]
483179007402	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
483179007403	dimer interface [polypeptide binding]; other site
483179007404	active site
483179007405	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
483179007406	dimer interface [polypeptide binding]; other site
483179007407	active site
483179007408	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
483179007409	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
483179007410	Substrate binding site; other site
483179007411	Mg++ binding site; other site
483179007412	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
483179007413	active site
483179007414	substrate binding site [chemical binding]; other site
483179007415	CoA binding site [chemical binding]; other site
483179007416	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
483179007417	Predicted integral membrane protein [Function unknown]; Region: COG0392
483179007418	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
483179007419	Uncharacterized conserved protein [Function unknown]; Region: COG2898
483179007420	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
483179007421	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
483179007422	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
483179007423	BA14K-like protein; Region: BA14K; pfam07886
483179007424	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
483179007425	PAS domain; Region: PAS_9; pfam13426
483179007426	putative active site [active]
483179007427	heme pocket [chemical binding]; other site
483179007428	PAS fold; Region: PAS_3; pfam08447
483179007429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
483179007430	putative active site [active]
483179007431	heme pocket [chemical binding]; other site
483179007432	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
483179007433	Histidine kinase; Region: HisKA_2; cl06527
483179007434	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
483179007435	EamA-like transporter family; Region: EamA; cl01037
483179007436	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
483179007437	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
483179007438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
483179007439	Mg2+ binding site [ion binding]; other site
483179007440	G-X-G motif; other site
483179007441	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
483179007442	anchoring element; other site
483179007443	dimer interface [polypeptide binding]; other site
483179007444	ATP binding site [chemical binding]; other site
483179007445	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
483179007446	active site
483179007447	metal binding site [ion binding]; metal-binding site
483179007448	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
483179007449	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
483179007450	Amidase; Region: Amidase; cl11426
483179007451	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
483179007452	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
483179007453	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
483179007454	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
483179007455	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
483179007456	active site
483179007457	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
483179007458	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
483179007459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007460	dihydroorotase; Validated; Region: PRK09059
483179007461	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
483179007462	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
483179007463	active site
483179007464	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
483179007465	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
483179007466	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
483179007467	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
483179007468	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
483179007469	active site
483179007470	interdomain interaction site; other site
483179007471	putative metal-binding site [ion binding]; other site
483179007472	nucleotide binding site [chemical binding]; other site
483179007473	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
483179007474	domain I; other site
483179007475	DNA binding groove [nucleotide binding]
483179007476	phosphate binding site [ion binding]; other site
483179007477	domain II; other site
483179007478	domain III; other site
483179007479	nucleotide binding site [chemical binding]; other site
483179007480	catalytic site [active]
483179007481	domain IV; other site
483179007482	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
483179007483	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
483179007484	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
483179007485	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
483179007486	ribonuclease R; Region: RNase_R; TIGR02063
483179007487	RNB domain; Region: RNB; pfam00773
483179007488	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
483179007489	RNA binding site [nucleotide binding]; other site
483179007490	Protein of unknown function (DUF983); Region: DUF983; cl02211
483179007491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179007492	putative substrate translocation pore; other site
483179007493	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
483179007494	response regulator PleD; Reviewed; Region: pleD; PRK09581
483179007495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179007496	active site
483179007497	phosphorylation site [posttranslational modification]
483179007498	intermolecular recognition site; other site
483179007499	dimerization interface [polypeptide binding]; other site
483179007500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179007501	active site
483179007502	phosphorylation site [posttranslational modification]
483179007503	intermolecular recognition site; other site
483179007504	dimerization interface [polypeptide binding]; other site
483179007505	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179007506	metal binding site [ion binding]; metal-binding site
483179007507	active site
483179007508	I-site; other site
483179007509	Response regulator receiver domain; Region: Response_reg; pfam00072
483179007510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
483179007511	active site
483179007512	phosphorylation site [posttranslational modification]
483179007513	intermolecular recognition site; other site
483179007514	dimerization interface [polypeptide binding]; other site
483179007515	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
483179007516	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
483179007517	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
483179007518	DNA polymerase IV; Provisional; Region: PRK02794
483179007519	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
483179007520	active site
483179007521	DNA binding site [nucleotide binding]
483179007522	Uncharacterized conserved protein [Function unknown]; Region: COG3391
483179007523	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
483179007524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179007525	metal binding site [ion binding]; metal-binding site
483179007526	active site
483179007527	I-site; other site
483179007528	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126
483179007529	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
483179007530	active site
483179007531	catalytic site [active]
483179007532	substrate binding site [chemical binding]; other site
483179007533	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179007534	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
483179007535	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179007536	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
483179007537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007538	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
483179007539	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
483179007540	substrate binding pocket [chemical binding]; other site
483179007541	membrane-bound complex binding site; other site
483179007542	hinge residues; other site
483179007543	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
483179007544	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
483179007545	substrate binding pocket [chemical binding]; other site
483179007546	membrane-bound complex binding site; other site
483179007547	hinge residues; other site
483179007548	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
483179007549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007550	Helix-turn-helix domains; Region: HTH; cl00088
483179007551	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
483179007552	AsnC family; Region: AsnC_trans_reg; pfam01037
483179007553	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
483179007554	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
483179007555	active site
483179007556	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
483179007557	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
483179007558	dimer interface [polypeptide binding]; other site
483179007559	active site
483179007560	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
483179007561	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
483179007562	Helix-turn-helix domains; Region: HTH; cl00088
483179007563	Bacterial transcriptional regulator; Region: IclR; pfam01614
483179007564	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
483179007565	Cupin domain; Region: Cupin_2; cl09118
483179007566	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179007567	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
483179007568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007570	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
483179007571	Helix-turn-helix domains; Region: HTH; cl00088
483179007572	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179007573	dimerization interface [polypeptide binding]; other site
483179007574	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
483179007575	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
483179007576	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
483179007577	Protocatechuate 3,4-dioxygenase beta subunit N terminal; Region: PCDO_beta_N; pfam12391
483179007578	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
483179007579	active site
483179007580	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
483179007581	tetramer interface [polypeptide binding]; other site
483179007582	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
483179007583	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
483179007584	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
483179007585	TM-ABC transporter signature motif; other site
483179007586	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
483179007587	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
483179007588	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
483179007589	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
483179007590	Walker A/P-loop; other site
483179007591	ATP binding site [chemical binding]; other site
483179007592	Q-loop/lid; other site
483179007593	ABC transporter signature motif; other site
483179007594	Walker B; other site
483179007595	D-loop; other site
483179007596	H-loop/switch region; other site
483179007597	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
483179007598	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
483179007599	Walker A/P-loop; other site
483179007600	ATP binding site [chemical binding]; other site
483179007601	Q-loop/lid; other site
483179007602	ABC transporter signature motif; other site
483179007603	Walker B; other site
483179007604	D-loop; other site
483179007605	H-loop/switch region; other site
483179007606	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
483179007607	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
483179007608	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
483179007609	active site
483179007610	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
483179007611	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
483179007612	active site
483179007613	dimer interface [polypeptide binding]; other site
483179007614	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
483179007615	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179007616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007617	dimer interface [polypeptide binding]; other site
483179007618	conserved gate region; other site
483179007619	ABC-ATPase subunit interface; other site
483179007620	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
483179007621	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
483179007622	Walker A/P-loop; other site
483179007623	ATP binding site [chemical binding]; other site
483179007624	Q-loop/lid; other site
483179007625	ABC transporter signature motif; other site
483179007626	Walker B; other site
483179007627	D-loop; other site
483179007628	H-loop/switch region; other site
483179007629	TOBE domain; Region: TOBE_2; cl01440
483179007630	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
483179007631	transmembrane helices; other site
483179007632	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
483179007633	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
483179007634	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
483179007635	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
483179007636	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
483179007637	nucleoside/Zn binding site; other site
483179007638	dimer interface [polypeptide binding]; other site
483179007639	catalytic motif [active]
483179007640	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
483179007641	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
483179007642	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
483179007643	EamA-like transporter family; Region: EamA; cl01037
483179007644	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
483179007645	homodimer interface [polypeptide binding]; other site
483179007646	substrate-cofactor binding pocket; other site
483179007647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179007648	catalytic residue [active]
483179007649	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
483179007650	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
483179007651	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
483179007652	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
483179007653	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
483179007654	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179007655	NAD binding site [chemical binding]; other site
483179007656	catalytic residues [active]
483179007657	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
483179007658	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
483179007659	putative ligand binding residues [chemical binding]; other site
483179007660	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
483179007661	ABC-ATPase subunit  interface; other site
483179007662	dimer interface [polypeptide binding]; other site
483179007663	putative PBP binding regions; other site
483179007664	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
483179007665	ABC-ATPase subunit  interface; other site
483179007666	dimer interface [polypeptide binding]; other site
483179007667	putative PBP binding regions; other site
483179007668	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
483179007669	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
483179007670	Walker A/P-loop; other site
483179007671	ATP binding site [chemical binding]; other site
483179007672	Q-loop/lid; other site
483179007673	ABC transporter signature motif; other site
483179007674	Walker B; other site
483179007675	D-loop; other site
483179007676	H-loop/switch region; other site
483179007677	Helix-turn-helix domains; Region: HTH; cl00088
483179007678	5-oxoprolinase; Region: PLN02666
483179007679	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
483179007680	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
483179007681	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
483179007682	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
483179007683	substrate binding pocket [chemical binding]; other site
483179007684	membrane-bound complex binding site; other site
483179007685	hinge residues; other site
483179007686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007687	dimer interface [polypeptide binding]; other site
483179007688	conserved gate region; other site
483179007689	putative PBP binding loops; other site
483179007690	ABC-ATPase subunit interface; other site
483179007691	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
483179007692	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179007693	Walker A/P-loop; other site
483179007694	ATP binding site [chemical binding]; other site
483179007695	Q-loop/lid; other site
483179007696	ABC transporter signature motif; other site
483179007697	Walker B; other site
483179007698	D-loop; other site
483179007699	H-loop/switch region; other site
483179007700	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
483179007701	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
483179007702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179007703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179007704	putative transporter; Provisional; Region: PRK10504
483179007705	putative substrate translocation pore; other site
483179007706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179007707	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
483179007708	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
483179007709	Walker A/P-loop; other site
483179007710	ATP binding site [chemical binding]; other site
483179007711	Q-loop/lid; other site
483179007712	ABC transporter signature motif; other site
483179007713	Walker B; other site
483179007714	D-loop; other site
483179007715	H-loop/switch region; other site
483179007716	TOBE domain; Region: TOBE_2; cl01440
483179007717	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
483179007718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007719	dimer interface [polypeptide binding]; other site
483179007720	conserved gate region; other site
483179007721	putative PBP binding loops; other site
483179007722	ABC-ATPase subunit interface; other site
483179007723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007724	dimer interface [polypeptide binding]; other site
483179007725	conserved gate region; other site
483179007726	putative PBP binding loops; other site
483179007727	ABC-ATPase subunit interface; other site
483179007728	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
483179007729	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179007730	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
483179007731	active site
483179007732	homopentamer interface [polypeptide binding]; other site
483179007733	dimer interface [polypeptide binding]; other site
483179007734	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
483179007735	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
483179007736	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
483179007737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007738	dimer interface [polypeptide binding]; other site
483179007739	conserved gate region; other site
483179007740	putative PBP binding loops; other site
483179007741	ABC-ATPase subunit interface; other site
483179007742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007743	dimer interface [polypeptide binding]; other site
483179007744	conserved gate region; other site
483179007745	putative PBP binding loops; other site
483179007746	ABC-ATPase subunit interface; other site
483179007747	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179007748	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
483179007749	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
483179007750	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
483179007751	Walker A/P-loop; other site
483179007752	ATP binding site [chemical binding]; other site
483179007753	Q-loop/lid; other site
483179007754	ABC transporter signature motif; other site
483179007755	Walker B; other site
483179007756	D-loop; other site
483179007757	H-loop/switch region; other site
483179007758	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
483179007759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007760	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
483179007761	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
483179007762	E-class dimer interface [polypeptide binding]; other site
483179007763	P-class dimer interface [polypeptide binding]; other site
483179007764	active site
483179007765	Cu2+ binding site [ion binding]; other site
483179007766	Zn2+ binding site [ion binding]; other site
483179007767	multicopper oxidase; Provisional; Region: PRK10965
483179007768	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179007769	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179007770	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
483179007771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179007772	metabolite-proton symporter; Region: 2A0106; TIGR00883
483179007773	putative substrate translocation pore; other site
483179007774	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
483179007775	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
483179007776	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
483179007777	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
483179007778	dimer interface [polypeptide binding]; other site
483179007779	decamer (pentamer of dimers) interface [polypeptide binding]; other site
483179007780	catalytic triad [active]
483179007781	peroxidatic and resolving cysteines [active]
483179007782	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
483179007783	Helix-turn-helix domains; Region: HTH; cl00088
483179007784	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
483179007785	dimerization interface [polypeptide binding]; other site
483179007786	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
483179007787	HTH DNA binding domain; Region: HTH_13; pfam11972
483179007788	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007789	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
483179007790	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
483179007791	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
483179007792	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
483179007793	putative active site [active]
483179007794	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
483179007795	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
483179007796	PYR/PP interface [polypeptide binding]; other site
483179007797	dimer interface [polypeptide binding]; other site
483179007798	TPP binding site [chemical binding]; other site
483179007799	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
483179007800	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
483179007801	TPP-binding site [chemical binding]; other site
483179007802	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
483179007803	KduI/IolB family; Region: KduI; cl01508
483179007804	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
483179007805	active site
483179007806	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
483179007807	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179007808	Walker A/P-loop; other site
483179007809	ATP binding site [chemical binding]; other site
483179007810	Q-loop/lid; other site
483179007811	ABC transporter signature motif; other site
483179007812	Walker B; other site
483179007813	D-loop; other site
483179007814	H-loop/switch region; other site
483179007815	TOBE domain; Region: TOBE_2; cl01440
483179007816	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
483179007817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007818	dimer interface [polypeptide binding]; other site
483179007819	conserved gate region; other site
483179007820	putative PBP binding loops; other site
483179007821	ABC-ATPase subunit interface; other site
483179007822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007823	dimer interface [polypeptide binding]; other site
483179007824	conserved gate region; other site
483179007825	putative PBP binding loops; other site
483179007826	ABC-ATPase subunit interface; other site
483179007827	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
483179007828	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179007829	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
483179007830	Proline dehydrogenase; Region: Pro_dh; cl03282
483179007831	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
483179007832	Glutamate binding site [chemical binding]; other site
483179007833	NAD binding site [chemical binding]; other site
483179007834	catalytic residues [active]
483179007835	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
483179007836	Helix-turn-helix domains; Region: HTH; cl00088
483179007837	AsnC family; Region: AsnC_trans_reg; pfam01037
483179007838	glycine dehydrogenase; Provisional; Region: PRK05367
483179007839	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
483179007840	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
483179007841	catalytic residue [active]
483179007842	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
483179007843	tetramer interface [polypeptide binding]; other site
483179007844	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179007845	catalytic residue [active]
483179007846	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
483179007847	lipoyl attachment site [posttranslational modification]; other site
483179007848	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
483179007849	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
483179007850	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
483179007851	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
483179007852	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179007853	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
483179007854	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
483179007855	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
483179007856	putative active site [active]
483179007857	N-formylglutamate amidohydrolase; Region: FGase; cl01522
483179007858	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
483179007859	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
483179007860	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
483179007861	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
483179007862	putative active site [active]
483179007863	metal binding site [ion binding]; metal-binding site
483179007864	BA14K-like protein; Region: BA14K; pfam07886
483179007865	EamA-like transporter family; Region: EamA; cl01037
483179007866	NMT1-like family; Region: NMT1_2; cl15260
483179007867	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
483179007868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007869	dimer interface [polypeptide binding]; other site
483179007870	conserved gate region; other site
483179007871	putative PBP binding loops; other site
483179007872	ABC-ATPase subunit interface; other site
483179007873	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
483179007874	This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea.  This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily.  The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294
483179007875	Walker A/P-loop; other site
483179007876	ATP binding site [chemical binding]; other site
483179007877	Q-loop/lid; other site
483179007878	ABC transporter signature motif; other site
483179007879	Walker B; other site
483179007880	D-loop; other site
483179007881	H-loop/switch region; other site
483179007882	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
483179007883	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
483179007884	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
483179007885	dimer interface [polypeptide binding]; other site
483179007886	active site
483179007887	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
483179007888	substrate binding site [chemical binding]; other site
483179007889	catalytic residue [active]
483179007890	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
483179007891	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
483179007892	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
483179007893	putative active site [active]
483179007894	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
483179007895	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
483179007896	Walker A/P-loop; other site
483179007897	ATP binding site [chemical binding]; other site
483179007898	Q-loop/lid; other site
483179007899	ABC transporter signature motif; other site
483179007900	Walker B; other site
483179007901	D-loop; other site
483179007902	H-loop/switch region; other site
483179007903	TOBE domain; Region: TOBE_2; cl01440
483179007904	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
483179007905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007906	NAD(P) binding site [chemical binding]; other site
483179007907	active site
483179007908	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179007909	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
483179007910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007911	dimer interface [polypeptide binding]; other site
483179007912	conserved gate region; other site
483179007913	putative PBP binding loops; other site
483179007914	ABC-ATPase subunit interface; other site
483179007915	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
483179007916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179007917	dimer interface [polypeptide binding]; other site
483179007918	conserved gate region; other site
483179007919	putative PBP binding loops; other site
483179007920	ABC-ATPase subunit interface; other site
483179007921	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
483179007922	homotrimer interaction site [polypeptide binding]; other site
483179007923	putative active site [active]
483179007924	Uncharacterized conserved protein [Function unknown]; Region: COG5476
483179007925	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
483179007926	MlrC C-terminus; Region: MlrC_C; pfam07171
483179007927	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
483179007928	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
483179007929	Walker A/P-loop; other site
483179007930	ATP binding site [chemical binding]; other site
483179007931	Q-loop/lid; other site
483179007932	ABC transporter signature motif; other site
483179007933	Walker B; other site
483179007934	D-loop; other site
483179007935	H-loop/switch region; other site
483179007936	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
483179007937	ABC-ATPase subunit  interface; other site
483179007938	dimer interface [polypeptide binding]; other site
483179007939	putative PBP binding regions; other site
483179007940	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
483179007941	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
483179007942	putative ligand binding residues [chemical binding]; other site
483179007943	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
483179007944	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179007945	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179007946	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
483179007947	Fusaric acid resistance protein family; Region: FUSC; pfam04632
483179007948	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
483179007949	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
483179007950	Helix-turn-helix domains; Region: HTH; cl00088
483179007951	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
483179007952	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
483179007953	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
483179007954	generic binding surface II; other site
483179007955	generic binding surface I; other site
483179007956	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
483179007957	Helix-turn-helix domains; Region: HTH; cl00088
483179007958	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179007959	dimerization interface [polypeptide binding]; other site
483179007960	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
483179007961	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
483179007962	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
483179007963	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
483179007964	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007965	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
483179007966	Helix-turn-helix domains; Region: HTH; cl00088
483179007967	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
483179007968	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179007969	putative DNA binding site [nucleotide binding]; other site
483179007970	putative Zn2+ binding site [ion binding]; other site
483179007971	AsnC family; Region: AsnC_trans_reg; pfam01037
483179007972	AzlC protein; Region: AzlC; cl00570
483179007973	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
483179007974	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
483179007975	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
483179007976	putative NAD(P) binding site [chemical binding]; other site
483179007977	active site
483179007978	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
483179007979	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
483179007980	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
483179007981	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
483179007982	putative active site [active]
483179007983	Dehydratase family; Region: ILVD_EDD; cl00340
483179007984	6-phosphogluconate dehydratase; Region: edd; TIGR01196
483179007985	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
483179007986	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
483179007987	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
483179007988	homodimer interface [polypeptide binding]; other site
483179007989	NADP binding site [chemical binding]; other site
483179007990	substrate binding site [chemical binding]; other site
483179007991	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
483179007992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179007993	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
483179007994	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179007995	Walker A/P-loop; other site
483179007996	ATP binding site [chemical binding]; other site
483179007997	Q-loop/lid; other site
483179007998	ABC transporter signature motif; other site
483179007999	Walker B; other site
483179008000	D-loop; other site
483179008001	H-loop/switch region; other site
483179008002	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179008003	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
483179008004	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008005	Walker A/P-loop; other site
483179008006	ATP binding site [chemical binding]; other site
483179008007	Q-loop/lid; other site
483179008008	ABC transporter signature motif; other site
483179008009	Walker B; other site
483179008010	D-loop; other site
483179008011	H-loop/switch region; other site
483179008012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008013	dimer interface [polypeptide binding]; other site
483179008014	conserved gate region; other site
483179008015	putative PBP binding loops; other site
483179008016	ABC-ATPase subunit interface; other site
483179008017	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
483179008018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008019	dimer interface [polypeptide binding]; other site
483179008020	conserved gate region; other site
483179008021	putative PBP binding loops; other site
483179008022	ABC-ATPase subunit interface; other site
483179008023	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
483179008024	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
483179008025	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
483179008026	active site clefts [active]
483179008027	zinc binding site [ion binding]; other site
483179008028	dimer interface [polypeptide binding]; other site
483179008029	tellurite resistance protein terB; Region: terB; cd07176
483179008030	putative metal binding site [ion binding]; other site
483179008031	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
483179008032	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
483179008033	active site
483179008034	nucleotide binding site [chemical binding]; other site
483179008035	HIGH motif; other site
483179008036	KMSKS motif; other site
483179008037	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
483179008038	Predicted transcriptional regulator [Transcription]; Region: COG2932
483179008039	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
483179008040	Catalytic site [active]
483179008041	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
483179008042	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
483179008043	substrate binding site [chemical binding]; other site
483179008044	oxyanion hole (OAH) forming residues; other site
483179008045	trimer interface [polypeptide binding]; other site
483179008046	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008047	LDH/MDH dimer interface [polypeptide binding]; other site
483179008048	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
483179008049	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
483179008050	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
483179008051	dimer interface [polypeptide binding]; other site
483179008052	active site
483179008053	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
483179008054	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
483179008055	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
483179008056	FAD binding site [chemical binding]; other site
483179008057	substrate binding site [chemical binding]; other site
483179008058	catalytic residues [active]
483179008059	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
483179008060	Transcriptional regulator [Transcription]; Region: LysR; COG0583
483179008061	Helix-turn-helix domains; Region: HTH; cl00088
483179008062	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
483179008063	putative dimerization interface [polypeptide binding]; other site
483179008064	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
483179008065	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
483179008066	active site
483179008067	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
483179008068	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008069	Walker A/P-loop; other site
483179008070	ATP binding site [chemical binding]; other site
483179008071	Q-loop/lid; other site
483179008072	ABC transporter signature motif; other site
483179008073	Walker B; other site
483179008074	D-loop; other site
483179008075	H-loop/switch region; other site
483179008076	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
483179008077	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008078	Walker A/P-loop; other site
483179008079	ATP binding site [chemical binding]; other site
483179008080	Q-loop/lid; other site
483179008081	ABC transporter signature motif; other site
483179008082	Walker B; other site
483179008083	D-loop; other site
483179008084	H-loop/switch region; other site
483179008085	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
483179008086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008087	dimer interface [polypeptide binding]; other site
483179008088	conserved gate region; other site
483179008089	putative PBP binding loops; other site
483179008090	ABC-ATPase subunit interface; other site
483179008091	nickel transporter permease NikB; Provisional; Region: PRK10352
483179008092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008093	dimer interface [polypeptide binding]; other site
483179008094	conserved gate region; other site
483179008095	putative PBP binding loops; other site
483179008096	ABC-ATPase subunit interface; other site
483179008097	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
483179008098	substrate binding site [chemical binding]; other site
483179008099	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
483179008100	nickel responsive regulator; Provisional; Region: PRK02967
483179008101	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
483179008102	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
483179008103	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
483179008104	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
483179008105	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
483179008106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
483179008107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
483179008108	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
483179008109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008110	putative PBP binding loops; other site
483179008111	ABC-ATPase subunit interface; other site
483179008112	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
483179008113	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179008114	Walker A/P-loop; other site
483179008115	ATP binding site [chemical binding]; other site
483179008116	Q-loop/lid; other site
483179008117	ABC transporter signature motif; other site
483179008118	Walker B; other site
483179008119	D-loop; other site
483179008120	H-loop/switch region; other site
483179008121	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
483179008122	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179008123	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
483179008124	Glucuronate isomerase; Region: UxaC; cl00829
483179008125	Transcriptional regulators [Transcription]; Region: GntR; COG1802
483179008126	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179008127	DNA-binding site [nucleotide binding]; DNA binding site
483179008128	FCD domain; Region: FCD; cl11656
483179008129	mannonate dehydratase; Region: uxuA; TIGR00695
483179008130	mannonate dehydratase; Provisional; Region: PRK03906
483179008131	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
483179008132	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179008133	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179008134	CrcB-like protein; Region: CRCB; cl09114
483179008135	CrcB-like protein; Region: CRCB; cl09114
483179008136	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
483179008137	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
483179008138	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
483179008139	DNA binding residues [nucleotide binding]
483179008140	putative dimer interface [polypeptide binding]; other site
483179008141	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
483179008142	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
483179008143	Sel1 repeat; Region: Sel1; cl02723
483179008144	Sel1 repeat; Region: Sel1; cl02723
483179008145	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
483179008146	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
483179008147	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
483179008148	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
483179008149	putative active site [active]
483179008150	putative metal binding site [ion binding]; other site
483179008151	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
483179008152	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
483179008153	ATP binding site [chemical binding]; other site
483179008154	putative Mg++ binding site [ion binding]; other site
483179008155	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
483179008156	nucleotide binding region [chemical binding]; other site
483179008157	ATP-binding site [chemical binding]; other site
483179008158	DEAD/H associated; Region: DEAD_assoc; pfam08494
483179008159	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
483179008160	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
483179008161	FMN binding site [chemical binding]; other site
483179008162	substrate binding site [chemical binding]; other site
483179008163	putative catalytic residue [active]
483179008164	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
483179008165	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
483179008166	HsdM N-terminal domain; Region: HsdM_N; pfam12161
483179008167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
483179008168	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
483179008169	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
483179008170	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
483179008171	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
483179008172	ATP binding site [chemical binding]; other site
483179008173	putative Mg++ binding site [ion binding]; other site
483179008174	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179008175	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
483179008176	Protein of unknown function DUF45; Region: DUF45; cl00636
483179008177	Protein of unknown function DUF91; Region: DUF91; cl00709
483179008178	Uncharacterized conserved protein [Function unknown]; Region: COG3586
483179008179	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179008180	DDE superfamily endonuclease; Region: DDE_4; cl15789
483179008181	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
483179008182	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
483179008183	inhibitor-cofactor binding pocket; inhibition site
483179008184	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179008185	catalytic residue [active]
483179008186	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
483179008187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008188	NAD(P) binding site [chemical binding]; other site
483179008189	active site
483179008190	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
483179008191	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
483179008192	Helix-turn-helix domains; Region: HTH; cl00088
483179008193	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
483179008194	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
483179008195	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
483179008196	ligand binding site [chemical binding]; other site
483179008197	dimerization interface [polypeptide binding]; other site
483179008198	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179008199	TM-ABC transporter signature motif; other site
483179008200	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
483179008201	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
483179008202	Walker A/P-loop; other site
483179008203	ATP binding site [chemical binding]; other site
483179008204	Q-loop/lid; other site
483179008205	ABC transporter signature motif; other site
483179008206	Walker B; other site
483179008207	D-loop; other site
483179008208	H-loop/switch region; other site
483179008209	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
483179008210	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395
483179008211	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
483179008212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008213	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
483179008214	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
483179008215	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
483179008216	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
483179008217	Helix-turn-helix domains; Region: HTH; cl00088
483179008218	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
483179008219	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
483179008220	substrate binding site [chemical binding]; other site
483179008221	dimer interface [polypeptide binding]; other site
483179008222	catalytic triad [active]
483179008223	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
483179008224	hypothetical protein; Provisional; Region: PRK08185
483179008225	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
483179008226	intersubunit interface [polypeptide binding]; other site
483179008227	active site
483179008228	zinc binding site [ion binding]; other site
483179008229	Na+ binding site [ion binding]; other site
483179008230	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
483179008231	AMP binding site [chemical binding]; other site
483179008232	metal binding site [ion binding]; metal-binding site
483179008233	active site
483179008234	Uncharacterized conserved protein [Function unknown]; Region: COG1739
483179008235	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
483179008236	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
483179008237	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
483179008238	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
483179008239	G1 box; other site
483179008240	putative GEF interaction site [polypeptide binding]; other site
483179008241	GTP/Mg2+ binding site [chemical binding]; other site
483179008242	Switch I region; other site
483179008243	G2 box; other site
483179008244	G3 box; other site
483179008245	Switch II region; other site
483179008246	G4 box; other site
483179008247	G5 box; other site
483179008248	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
483179008249	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
483179008250	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
483179008251	MgtE intracellular N domain; Region: MgtE_N; cl15244
483179008252	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
483179008253	Divalent cation transporter; Region: MgtE; cl00786
483179008254	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
483179008255	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
483179008256	active site
483179008257	Zn binding site [ion binding]; other site
483179008258	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
483179008259	dimer interface [polypeptide binding]; other site
483179008260	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179008261	Domain of unknown function (DUF1737); Region: DUF1737; cl10503
483179008262	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
483179008263	substrate binding site [chemical binding]; other site
483179008264	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
483179008265	OsmC-like protein; Region: OsmC; cl00767
483179008266	Transcriptional regulators [Transcription]; Region: MarR; COG1846
483179008267	Helix-turn-helix domains; Region: HTH; cl00088
483179008268	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
483179008269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008270	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
483179008271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179008272	putative substrate translocation pore; other site
483179008273	metabolite-proton symporter; Region: 2A0106; TIGR00883
483179008274	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
483179008275	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
483179008276	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
483179008277	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
483179008278	DNA binding site [nucleotide binding]
483179008279	active site
483179008280	tartrate dehydrogenase; Provisional; Region: PRK08194
483179008281	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
483179008282	Trm112p-like protein; Region: Trm112p; cl01066
483179008283	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
483179008284	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
483179008285	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
483179008286	catalytic residues [active]
483179008287	Uncharacterized conserved protein [Function unknown]; Region: COG3760
483179008288	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
483179008289	putative deacylase active site [active]
483179008290	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
483179008291	apolar tunnel; other site
483179008292	heme binding site [chemical binding]; other site
483179008293	dimerization interface [polypeptide binding]; other site
483179008294	ornithine cyclodeaminase; Validated; Region: PRK07589
483179008295	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008296	Arginase family; Region: Arginase; cl00306
483179008297	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
483179008298	Helix-turn-helix domains; Region: HTH; cl00088
483179008299	AsnC family; Region: AsnC_trans_reg; pfam01037
483179008300	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
483179008301	FMN binding site [chemical binding]; other site
483179008302	active site
483179008303	substrate binding site [chemical binding]; other site
483179008304	catalytic residue [active]
483179008305	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
483179008306	dimerization interface [polypeptide binding]; other site
483179008307	putative DNA binding site [nucleotide binding]; other site
483179008308	putative Zn2+ binding site [ion binding]; other site
483179008309	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
483179008310	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
483179008311	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
483179008312	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
483179008313	RNA binding site [nucleotide binding]; other site
483179008314	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008315	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
483179008316	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
483179008317	Helix-turn-helix domains; Region: HTH; cl00088
483179008318	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179008319	dimerization interface [polypeptide binding]; other site
483179008320	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
483179008321	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179008322	tetrameric interface [polypeptide binding]; other site
483179008323	NAD binding site [chemical binding]; other site
483179008324	catalytic residues [active]
483179008325	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
483179008326	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
483179008327	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
483179008328	putative active site [active]
483179008329	putative substrate binding site [chemical binding]; other site
483179008330	putative cosubstrate binding site; other site
483179008331	catalytic site [active]
483179008332	hypothetical protein; Provisional; Region: PRK02947
483179008333	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
483179008334	putative active site [active]
483179008335	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
483179008336	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
483179008337	active site
483179008338	dimer interface [polypeptide binding]; other site
483179008339	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
483179008340	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
483179008341	dimer interface [polypeptide binding]; other site
483179008342	active site
483179008343	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
483179008344	dimer interface [polypeptide binding]; other site
483179008345	active site
483179008346	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
483179008347	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179008348	DNA-binding site [nucleotide binding]; DNA binding site
483179008349	UTRA domain; Region: UTRA; cl01230
483179008350	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
483179008351	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
483179008352	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179008353	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179008354	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
483179008355	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179008356	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179008357	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
483179008358	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
483179008359	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
483179008360	putative molybdopterin cofactor binding site [chemical binding]; other site
483179008361	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
483179008362	putative molybdopterin cofactor binding site; other site
483179008363	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
483179008364	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
483179008365	phosphate binding site [ion binding]; other site
483179008366	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
483179008367	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
483179008368	Helix-turn-helix domains; Region: HTH; cl00088
483179008369	AsnC family; Region: AsnC_trans_reg; pfam01037
483179008370	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
483179008371	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
483179008372	active site
483179008373	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
483179008374	dimer interface [polypeptide binding]; other site
483179008375	substrate binding site [chemical binding]; other site
483179008376	catalytic residues [active]
483179008377	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
483179008378	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
483179008379	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
483179008380	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
483179008381	non-specific DNA binding site [nucleotide binding]; other site
483179008382	salt bridge; other site
483179008383	sequence-specific DNA binding site [nucleotide binding]; other site
483179008384	Cupin domain; Region: Cupin_2; cl09118
483179008385	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
483179008386	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
483179008387	inhibitor-cofactor binding pocket; inhibition site
483179008388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179008389	catalytic residue [active]
483179008390	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
483179008391	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179008392	DNA-binding site [nucleotide binding]; DNA binding site
483179008393	UTRA domain; Region: UTRA; cl01230
483179008394	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
483179008395	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
483179008396	active site
483179008397	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
483179008398	active sites [active]
483179008399	tetramer interface [polypeptide binding]; other site
483179008400	N-formylglutamate amidohydrolase; Region: FGase; cl01522
483179008401	urocanate hydratase; Provisional; Region: PRK05414
483179008402	HutD; Region: HutD; cl01532
483179008403	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
483179008404	homodimer interface [polypeptide binding]; other site
483179008405	substrate-cofactor binding pocket; other site
483179008406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179008407	catalytic residue [active]
483179008408	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179008409	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179008410	TM-ABC transporter signature motif; other site
483179008411	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
483179008412	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
483179008413	Walker A/P-loop; other site
483179008414	ATP binding site [chemical binding]; other site
483179008415	Q-loop/lid; other site
483179008416	ABC transporter signature motif; other site
483179008417	Walker B; other site
483179008418	D-loop; other site
483179008419	H-loop/switch region; other site
483179008420	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
483179008421	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
483179008422	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
483179008423	putative ligand binding site [chemical binding]; other site
483179008424	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
483179008425	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
483179008426	active site
483179008427	intersubunit interface [polypeptide binding]; other site
483179008428	catalytic residue [active]
483179008429	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
483179008430	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
483179008431	Dehydratase family; Region: ILVD_EDD; cl00340
483179008432	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
483179008433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
483179008435	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
483179008436	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
483179008437	thiamine pyrophosphate protein; Validated; Region: PRK08199
483179008438	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
483179008439	PYR/PP interface [polypeptide binding]; other site
483179008440	dimer interface [polypeptide binding]; other site
483179008441	TPP binding site [chemical binding]; other site
483179008442	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
483179008443	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
483179008444	TPP-binding site [chemical binding]; other site
483179008445	D-aminopeptidase; Reviewed; Region: PRK13128
483179008446	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179008447	D-aminopeptidase, domain B; Region: DAP_B; pfam07930
483179008448	D-aminopeptidase, domain C; Region: DAP_C; pfam07932
483179008449	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
483179008450	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
483179008451	substrate binding pocket [chemical binding]; other site
483179008452	membrane-bound complex binding site; other site
483179008453	hinge residues; other site
483179008454	hypothetical protein; Provisional; Region: PRK06148
483179008455	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179008456	active site
483179008457	substrate binding site [chemical binding]; other site
483179008458	ATP binding site [chemical binding]; other site
483179008459	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
483179008460	inhibitor-cofactor binding pocket; inhibition site
483179008461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179008462	catalytic residue [active]
483179008463	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
483179008464	Helix-turn-helix domains; Region: HTH; cl00088
483179008465	AsnC family; Region: AsnC_trans_reg; pfam01037
483179008466	Transcriptional regulator [Transcription]; Region: LysR; COG0583
483179008467	Helix-turn-helix domains; Region: HTH; cl00088
483179008468	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179008469	dimerization interface [polypeptide binding]; other site
483179008470	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
483179008471	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
483179008472	putative ligand binding site [chemical binding]; other site
483179008473	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
483179008474	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
483179008475	Walker A/P-loop; other site
483179008476	ATP binding site [chemical binding]; other site
483179008477	Q-loop/lid; other site
483179008478	ABC transporter signature motif; other site
483179008479	Walker B; other site
483179008480	D-loop; other site
483179008481	H-loop/switch region; other site
483179008482	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
483179008483	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
483179008484	Walker A/P-loop; other site
483179008485	ATP binding site [chemical binding]; other site
483179008486	Q-loop/lid; other site
483179008487	ABC transporter signature motif; other site
483179008488	Walker B; other site
483179008489	D-loop; other site
483179008490	H-loop/switch region; other site
483179008491	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
483179008492	TM-ABC transporter signature motif; other site
483179008493	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
483179008494	TM-ABC transporter signature motif; other site
483179008495	choline dehydrogenase; Validated; Region: PRK02106
483179008496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008497	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
483179008498	NMT1-like family; Region: NMT1_2; cl15260
483179008499	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
483179008500	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
483179008501	Walker A/P-loop; other site
483179008502	ATP binding site [chemical binding]; other site
483179008503	Q-loop/lid; other site
483179008504	ABC transporter signature motif; other site
483179008505	Walker B; other site
483179008506	D-loop; other site
483179008507	H-loop/switch region; other site
483179008508	NIL domain; Region: NIL; cl09633
483179008509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
483179008510	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
483179008511	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179008512	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
483179008513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
483179008514	binding surface
483179008515	TPR motif; other site
483179008516	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
483179008517	binding surface
483179008518	TPR motif; other site
483179008519	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
483179008520	binding surface
483179008521	TPR motif; other site
483179008522	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
483179008523	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
483179008524	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
483179008525	putative active site [active]
483179008526	putative catalytic site [active]
483179008527	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
483179008528	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179008529	motif II; other site
483179008530	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
483179008531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008532	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
483179008533	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
483179008534	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
483179008535	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
483179008536	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
483179008537	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
483179008538	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
483179008539	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
483179008540	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
483179008541	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
483179008542	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
483179008543	PAS fold; Region: PAS_7; pfam12860
483179008544	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179008545	metal binding site [ion binding]; metal-binding site
483179008546	active site
483179008547	I-site; other site
483179008548	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
483179008549	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
483179008550	classical (c) SDRs; Region: SDR_c; cd05233
483179008551	NAD(P) binding site [chemical binding]; other site
483179008552	active site
483179008553	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
483179008554	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008555	Transcriptional regulators [Transcription]; Region: PurR; COG1609
483179008556	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
483179008557	DNA binding site [nucleotide binding]
483179008558	domain linker motif; other site
483179008559	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
483179008560	putative dimerization interface [polypeptide binding]; other site
483179008561	putative ligand binding site [chemical binding]; other site
483179008562	Creatinine amidohydrolase; Region: Creatininase; cl00618
483179008563	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
483179008564	P-loop, Walker A motif; other site
483179008565	Base recognition motif; other site
483179008566	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
483179008567	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
483179008568	structural tetrad; other site
483179008569	Predicted esterase [General function prediction only]; Region: COG0400
483179008570	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179008571	TMAO/DMSO reductase; Reviewed; Region: PRK05363
483179008572	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
483179008573	Moco binding site; other site
483179008574	metal coordination site [ion binding]; other site
483179008575	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
483179008576	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
483179008577	homotrimer interaction site [polypeptide binding]; other site
483179008578	putative active site [active]
483179008579	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179008580	TM-ABC transporter signature motif; other site
483179008581	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179008582	TM-ABC transporter signature motif; other site
483179008583	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
483179008584	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
483179008585	Walker A/P-loop; other site
483179008586	ATP binding site [chemical binding]; other site
483179008587	Q-loop/lid; other site
483179008588	ABC transporter signature motif; other site
483179008589	Walker B; other site
483179008590	D-loop; other site
483179008591	H-loop/switch region; other site
483179008592	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
483179008593	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
483179008594	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
483179008595	putative ligand binding site [chemical binding]; other site
483179008596	Transcriptional regulator [Transcription]; Region: IclR; COG1414
483179008597	Helix-turn-helix domains; Region: HTH; cl00088
483179008598	Bacterial transcriptional regulator; Region: IclR; pfam01614
483179008599	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
483179008600	dimer interface [polypeptide binding]; other site
483179008601	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
483179008602	metal binding site [ion binding]; metal-binding site
483179008603	glutathionine S-transferase; Provisional; Region: PRK10542
483179008604	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
483179008605	C-terminal domain interface [polypeptide binding]; other site
483179008606	GSH binding site (G-site) [chemical binding]; other site
483179008607	dimer interface [polypeptide binding]; other site
483179008608	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
483179008609	dimer interface [polypeptide binding]; other site
483179008610	N-terminal domain interface [polypeptide binding]; other site
483179008611	substrate binding pocket (H-site) [chemical binding]; other site
483179008612	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
483179008613	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
483179008614	metal binding site [ion binding]; metal-binding site
483179008615	active site
483179008616	I-site; other site
483179008617	hydroxyglutarate oxidase; Provisional; Region: PRK11728
483179008618	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008619	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
483179008620	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
483179008621	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
483179008622	active site
483179008623	catalytic site [active]
483179008624	substrate binding site [chemical binding]; other site
483179008625	amidase; Provisional; Region: PRK07042
483179008626	Amidase; Region: Amidase; cl11426
483179008627	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
483179008628	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008629	Walker A/P-loop; other site
483179008630	ATP binding site [chemical binding]; other site
483179008631	Q-loop/lid; other site
483179008632	ABC transporter signature motif; other site
483179008633	Walker B; other site
483179008634	D-loop; other site
483179008635	H-loop/switch region; other site
483179008636	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179008637	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
483179008638	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008639	Walker A/P-loop; other site
483179008640	ATP binding site [chemical binding]; other site
483179008641	Q-loop/lid; other site
483179008642	ABC transporter signature motif; other site
483179008643	Walker B; other site
483179008644	D-loop; other site
483179008645	H-loop/switch region; other site
483179008646	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179008647	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
483179008648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008649	dimer interface [polypeptide binding]; other site
483179008650	conserved gate region; other site
483179008651	putative PBP binding loops; other site
483179008652	ABC-ATPase subunit interface; other site
483179008653	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
483179008654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008655	dimer interface [polypeptide binding]; other site
483179008656	conserved gate region; other site
483179008657	putative PBP binding loops; other site
483179008658	ABC-ATPase subunit interface; other site
483179008659	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
483179008660	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
483179008661	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
483179008662	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
483179008663	putative NAD(P) binding site [chemical binding]; other site
483179008664	active site
483179008665	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179008666	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
483179008667	NAD(P) binding site [chemical binding]; other site
483179008668	catalytic residues [active]
483179008669	catalytic residues [active]
483179008670	Transcriptional regulators [Transcription]; Region: GntR; COG1802
483179008671	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179008672	DNA-binding site [nucleotide binding]; DNA binding site
483179008673	FCD domain; Region: FCD; cl11656
483179008674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179008675	Major Facilitator Superfamily; Region: MFS_1; pfam07690
483179008676	putative substrate translocation pore; other site
483179008677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
483179008678	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
483179008679	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
483179008680	homotrimer interaction site [polypeptide binding]; other site
483179008681	putative active site [active]
483179008682	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
483179008683	Ribonuclease P; Region: Ribonuclease_P; cl00457
483179008684	membrane protein insertase; Provisional; Region: PRK01318
483179008685	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
483179008686	Predicted GTPase [General function prediction only]; Region: COG0218
483179008687	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
483179008688	G1 box; other site
483179008689	GTP/Mg2+ binding site [chemical binding]; other site
483179008690	Switch I region; other site
483179008691	G2 box; other site
483179008692	G3 box; other site
483179008693	Switch II region; other site
483179008694	G4 box; other site
483179008695	G5 box; other site
483179008696	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
483179008697	feedback inhibition sensing region; other site
483179008698	homohexameric interface [polypeptide binding]; other site
483179008699	nucleotide binding site [chemical binding]; other site
483179008700	N-acetyl-L-glutamate binding site [chemical binding]; other site
483179008701	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
483179008702	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
483179008703	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
483179008704	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
483179008705	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
483179008706	trimer interface [polypeptide binding]; other site
483179008707	active site
483179008708	substrate binding site [chemical binding]; other site
483179008709	CoA binding site [chemical binding]; other site
483179008710	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
483179008711	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
483179008712	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
483179008713	metal binding site [ion binding]; metal-binding site
483179008714	dimer interface [polypeptide binding]; other site
483179008715	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
483179008716	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
483179008717	dimerization interface 3.5A [polypeptide binding]; other site
483179008718	active site
483179008719	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
483179008720	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
483179008721	putative active site [active]
483179008722	substrate binding site [chemical binding]; other site
483179008723	putative cosubstrate binding site; other site
483179008724	catalytic site [active]
483179008725	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
483179008726	substrate binding site [chemical binding]; other site
483179008727	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
483179008728	active site
483179008729	catalytic residues [active]
483179008730	metal binding site [ion binding]; metal-binding site
483179008731	RmuC family; Region: RmuC; pfam02646
483179008732	Rdx family; Region: Rdx; cl01407
483179008733	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
483179008734	GIY-YIG motif/motif A; other site
483179008735	putative active site [active]
483179008736	putative metal binding site [ion binding]; other site
483179008737	GTP-binding protein LepA; Provisional; Region: PRK05433
483179008738	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
483179008739	G1 box; other site
483179008740	putative GEF interaction site [polypeptide binding]; other site
483179008741	GTP/Mg2+ binding site [chemical binding]; other site
483179008742	Switch I region; other site
483179008743	G2 box; other site
483179008744	G3 box; other site
483179008745	Switch II region; other site
483179008746	G4 box; other site
483179008747	G5 box; other site
483179008748	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
483179008749	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
483179008750	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
483179008751	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
483179008752	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
483179008753	putative NAD(P) binding site [chemical binding]; other site
483179008754	active site
483179008755	Bacitracin resistance protein BacA; Region: BacA; cl00858
483179008756	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
483179008757	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
483179008758	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
483179008759	N-terminal domain interface [polypeptide binding]; other site
483179008760	dimer interface [polypeptide binding]; other site
483179008761	substrate binding pocket (H-site) [chemical binding]; other site
483179008762	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
483179008763	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
483179008764	HEAT repeat; Region: HEAT; pfam02985
483179008765	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
483179008766	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
483179008767	putative NAD(P) binding site [chemical binding]; other site
483179008768	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
483179008769	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
483179008770	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
483179008771	active site
483179008772	dimer interfaces [polypeptide binding]; other site
483179008773	catalytic residues [active]
483179008774	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
483179008775	glucokinase, proteobacterial type; Region: glk; TIGR00749
483179008776	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
483179008777	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
483179008778	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
483179008779	Walker A/P-loop; other site
483179008780	ATP binding site [chemical binding]; other site
483179008781	Q-loop/lid; other site
483179008782	ABC transporter signature motif; other site
483179008783	Walker B; other site
483179008784	D-loop; other site
483179008785	H-loop/switch region; other site
483179008786	dihydrodipicolinate reductase; Provisional; Region: PRK00048
483179008787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008788	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
483179008789	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
483179008790	catalytic core [active]
483179008791	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
483179008792	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
483179008793	active site
483179008794	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
483179008795	putative FMN binding site [chemical binding]; other site
483179008796	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
483179008797	Ligand Binding Site [chemical binding]; other site
483179008798	YhhN-like protein; Region: YhhN; cl01505
483179008799	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
483179008800	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
483179008801	NAD(P) binding site [chemical binding]; other site
483179008802	catalytic residues [active]
483179008803	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
483179008804	putative catalytic site [active]
483179008805	putative metal binding site [ion binding]; other site
483179008806	putative phosphate binding site [ion binding]; other site
483179008807	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
483179008808	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
483179008809	putative active site [active]
483179008810	catalytic site [active]
483179008811	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
483179008812	putative active site [active]
483179008813	catalytic site [active]
483179008814	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
483179008815	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
483179008816	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
483179008817	G1 box; other site
483179008818	putative GEF interaction site [polypeptide binding]; other site
483179008819	GTP/Mg2+ binding site [chemical binding]; other site
483179008820	Switch I region; other site
483179008821	G2 box; other site
483179008822	G3 box; other site
483179008823	Switch II region; other site
483179008824	G4 box; other site
483179008825	G5 box; other site
483179008826	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
483179008827	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
483179008828	Flavoprotein; Region: Flavoprotein; cl08021
483179008829	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
483179008830	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
483179008831	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179008832	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
483179008833	active site
483179008834	ATP binding site [chemical binding]; other site
483179008835	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
483179008836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
483179008837	S-adenosylmethionine binding site [chemical binding]; other site
483179008838	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
483179008839	active site
483179008840	SlyX; Region: SlyX; cl01090
483179008841	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
483179008842	putative transposase OrfB; Reviewed; Region: PHA02517
483179008843	HTH-like domain; Region: HTH_21; pfam13276
483179008844	Integrase core domain; Region: rve; cl01316
483179008845	Integrase core domain; Region: rve_3; cl15866
483179008846	Helix-turn-helix domains; Region: HTH; cl00088
483179008847	Transcriptional regulators [Transcription]; Region: GntR; COG1802
483179008848	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179008849	DNA-binding site [nucleotide binding]; DNA binding site
483179008850	FCD domain; Region: FCD; cl11656
483179008851	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179008852	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
483179008853	tetramerization interface [polypeptide binding]; other site
483179008854	NAD(P) binding site [chemical binding]; other site
483179008855	catalytic residues [active]
483179008856	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
483179008857	CoA-transferase family III; Region: CoA_transf_3; pfam02515
483179008858	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
483179008859	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008860	Walker A/P-loop; other site
483179008861	ATP binding site [chemical binding]; other site
483179008862	Q-loop/lid; other site
483179008863	ABC transporter signature motif; other site
483179008864	Walker B; other site
483179008865	D-loop; other site
483179008866	H-loop/switch region; other site
483179008867	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179008868	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
483179008869	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008870	Walker A/P-loop; other site
483179008871	ATP binding site [chemical binding]; other site
483179008872	Q-loop/lid; other site
483179008873	ABC transporter signature motif; other site
483179008874	Walker B; other site
483179008875	D-loop; other site
483179008876	H-loop/switch region; other site
483179008877	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179008878	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
483179008879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008880	dimer interface [polypeptide binding]; other site
483179008881	conserved gate region; other site
483179008882	putative PBP binding loops; other site
483179008883	ABC-ATPase subunit interface; other site
483179008884	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
483179008885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008886	dimer interface [polypeptide binding]; other site
483179008887	conserved gate region; other site
483179008888	putative PBP binding loops; other site
483179008889	ABC-ATPase subunit interface; other site
483179008890	Transcriptional regulator [Transcription]; Region: IclR; COG1414
483179008891	Helix-turn-helix domains; Region: HTH; cl00088
483179008892	Bacterial transcriptional regulator; Region: IclR; pfam01614
483179008893	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
483179008894	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
483179008895	E3 interaction surface; other site
483179008896	lipoyl attachment site [posttranslational modification]; other site
483179008897	e3 binding domain; Region: E3_binding; pfam02817
483179008898	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
483179008899	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
483179008900	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
483179008901	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
483179008902	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
483179008903	tetramer interface [polypeptide binding]; other site
483179008904	TPP-binding site [chemical binding]; other site
483179008905	heterodimer interface [polypeptide binding]; other site
483179008906	phosphorylation loop region [posttranslational modification]
483179008907	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
483179008908	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
483179008909	alpha subunit interface [polypeptide binding]; other site
483179008910	TPP binding site [chemical binding]; other site
483179008911	heterodimer interface [polypeptide binding]; other site
483179008912	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
483179008913	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
483179008914	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
483179008915	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
483179008916	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
483179008917	enoyl-CoA hydratase; Provisional; Region: PRK08138
483179008918	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
483179008919	substrate binding site [chemical binding]; other site
483179008920	oxyanion hole (OAH) forming residues; other site
483179008921	trimer interface [polypeptide binding]; other site
483179008922	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
483179008923	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
483179008924	active site
483179008925	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
483179008926	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
483179008927	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
483179008928	active site
483179008929	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
483179008930	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
483179008931	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
483179008932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008933	dimer interface [polypeptide binding]; other site
483179008934	conserved gate region; other site
483179008935	putative PBP binding loops; other site
483179008936	ABC-ATPase subunit interface; other site
483179008937	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
483179008938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008939	dimer interface [polypeptide binding]; other site
483179008940	conserved gate region; other site
483179008941	putative PBP binding loops; other site
483179008942	ABC-ATPase subunit interface; other site
483179008943	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
483179008944	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008945	Walker A/P-loop; other site
483179008946	ATP binding site [chemical binding]; other site
483179008947	Q-loop/lid; other site
483179008948	ABC transporter signature motif; other site
483179008949	Walker B; other site
483179008950	D-loop; other site
483179008951	H-loop/switch region; other site
483179008952	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179008953	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
483179008954	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
483179008955	Walker A/P-loop; other site
483179008956	ATP binding site [chemical binding]; other site
483179008957	Q-loop/lid; other site
483179008958	ABC transporter signature motif; other site
483179008959	Walker B; other site
483179008960	D-loop; other site
483179008961	H-loop/switch region; other site
483179008962	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
483179008963	Transcriptional regulators [Transcription]; Region: GntR; COG1802
483179008964	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179008965	DNA-binding site [nucleotide binding]; DNA binding site
483179008966	FCD domain; Region: FCD; cl11656
483179008967	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
483179008968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008969	dimer interface [polypeptide binding]; other site
483179008970	conserved gate region; other site
483179008971	putative PBP binding loops; other site
483179008972	ABC-ATPase subunit interface; other site
483179008973	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
483179008974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008975	dimer interface [polypeptide binding]; other site
483179008976	conserved gate region; other site
483179008977	putative PBP binding loops; other site
483179008978	ABC-ATPase subunit interface; other site
483179008979	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
483179008980	amidase; Provisional; Region: PRK07486
483179008981	Amidase; Region: Amidase; cl11426
483179008982	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
483179008983	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179008984	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
483179008985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008986	dimer interface [polypeptide binding]; other site
483179008987	conserved gate region; other site
483179008988	putative PBP binding loops; other site
483179008989	ABC-ATPase subunit interface; other site
483179008990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179008991	dimer interface [polypeptide binding]; other site
483179008992	conserved gate region; other site
483179008993	putative PBP binding loops; other site
483179008994	ABC-ATPase subunit interface; other site
483179008995	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
483179008996	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
483179008997	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
483179008998	catalytic residue [active]
483179008999	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
483179009000	intersubunit interface [polypeptide binding]; other site
483179009001	active site
483179009002	Zn2+ binding site [ion binding]; other site
483179009003	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
483179009004	PemK-like protein; Region: PemK; cl00995
483179009005	putative transposase OrfB; Reviewed; Region: PHA02517
483179009006	HTH-like domain; Region: HTH_21; pfam13276
483179009007	Integrase core domain; Region: rve; cl01316
483179009008	Integrase core domain; Region: rve_3; cl15866
483179009009	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
483179009010	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
483179009011	Rrf2 family protein; Region: rrf2_super; TIGR00738
483179009012	Helix-turn-helix domains; Region: HTH; cl00088
483179009013	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
483179009014	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179009015	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
483179009016	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
483179009017	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
483179009018	metal binding site [ion binding]; metal-binding site
483179009019	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
483179009020	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
483179009021	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
483179009022	ABC-ATPase subunit  interface; other site
483179009023	dimer interface [polypeptide binding]; other site
483179009024	putative PBP binding regions; other site
483179009025	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
483179009026	metal binding site 2 [ion binding]; metal-binding site
483179009027	putative DNA binding helix; other site
483179009028	metal binding site 1 [ion binding]; metal-binding site
483179009029	dimer interface [polypeptide binding]; other site
483179009030	structural Zn2+ binding site [ion binding]; other site
483179009031	Rod binding protein; Region: Rod-binding; cl01626
483179009032	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
483179009033	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
483179009034	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
483179009035	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
483179009036	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
483179009037	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
483179009038	Flagellar protein FlbT; Region: FlbT; cl11455
483179009039	Flagellar protein FlaF; Region: FlaF; cl11454
483179009040	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
483179009041	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
483179009042	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
483179009043	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
483179009044	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
483179009045	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
483179009046	Flagella basal body rod protein; Region: Flg_bb_rod; cl16922
483179009047	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
483179009048	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
483179009049	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
483179009050	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
483179009051	DNA binding site [nucleotide binding]
483179009052	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
483179009053	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
483179009054	N-acetyl-D-glucosamine binding site [chemical binding]; other site
483179009055	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
483179009056	chemotaxis protein; Reviewed; Region: PRK12798
483179009057	flagellar motor protein MotB; Validated; Region: motB; PRK05996
483179009058	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
483179009059	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
483179009060	ligand binding site [chemical binding]; other site
483179009061	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
483179009062	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
483179009063	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
483179009064	flagellin; Reviewed; Region: PRK12687
483179009065	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
483179009066	Uncharacterized conserved protein [Function unknown]; Region: COG3268
483179009067	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
483179009068	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
483179009069	putative ligand binding site [chemical binding]; other site
483179009070	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
483179009071	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
483179009072	Walker A/P-loop; other site
483179009073	ATP binding site [chemical binding]; other site
483179009074	Q-loop/lid; other site
483179009075	ABC transporter signature motif; other site
483179009076	Walker B; other site
483179009077	D-loop; other site
483179009078	H-loop/switch region; other site
483179009079	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
483179009080	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179009081	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
483179009082	TM-ABC transporter signature motif; other site
483179009083	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
483179009084	Helix-turn-helix domains; Region: HTH; cl00088
483179009085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179009086	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179009087	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
483179009088	NAD(P) binding site [chemical binding]; other site
483179009089	catalytic residues [active]
483179009090	choline dehydrogenase; Validated; Region: PRK02106
483179009091	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
483179009092	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
483179009093	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
483179009094	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
483179009095	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179009096	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
483179009097	NAD binding site [chemical binding]; other site
483179009098	catalytic residues [active]
483179009099	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
483179009100	putative substrate binding pocket [chemical binding]; other site
483179009101	trimer interface [polypeptide binding]; other site
483179009102	Helix-turn-helix domains; Region: HTH; cl00088
483179009103	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
483179009104	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
483179009105	Phosphotransferase enzyme family; Region: APH; pfam01636
483179009106	active site
483179009107	ATP binding site [chemical binding]; other site
483179009108	substrate binding site [chemical binding]; other site
483179009109	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
483179009110	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
483179009111	inhibitor-cofactor binding pocket; inhibition site
483179009112	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179009113	catalytic residue [active]
483179009114	hypothetical protein; Provisional; Region: PRK07481
483179009115	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
483179009116	inhibitor-cofactor binding pocket; inhibition site
483179009117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
483179009118	catalytic residue [active]
483179009119	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
483179009120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
483179009121	motif II; other site
483179009122	Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262
483179009123	Transcriptional regulator [Transcription]; Region: IclR; COG1414
483179009124	Helix-turn-helix domains; Region: HTH; cl00088
483179009125	Bacterial transcriptional regulator; Region: IclR; pfam01614
483179009126	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
483179009127	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
483179009128	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
483179009129	NAD(P) binding site [chemical binding]; other site
483179009130	catalytic residues [active]
483179009131	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
483179009132	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
483179009133	active site
483179009134	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
483179009135	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
483179009136	putative ligand binding site [chemical binding]; other site
483179009137	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
483179009138	TM-ABC transporter signature motif; other site
483179009139	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
483179009140	TM-ABC transporter signature motif; other site
483179009141	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
483179009142	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
483179009143	Walker A/P-loop; other site
483179009144	ATP binding site [chemical binding]; other site
483179009145	Q-loop/lid; other site
483179009146	ABC transporter signature motif; other site
483179009147	Walker B; other site
483179009148	D-loop; other site
483179009149	H-loop/switch region; other site
483179009150	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
483179009151	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
483179009152	Walker A/P-loop; other site
483179009153	ATP binding site [chemical binding]; other site
483179009154	Q-loop/lid; other site
483179009155	ABC transporter signature motif; other site
483179009156	Walker B; other site
483179009157	D-loop; other site
483179009158	H-loop/switch region; other site
483179009159	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
483179009160	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
483179009161	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
483179009162	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
483179009163	DNA-binding site [nucleotide binding]; DNA binding site
483179009164	UTRA domain; Region: UTRA; cl01230
483179009165	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
483179009166	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
483179009167	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
483179009168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179009169	dimer interface [polypeptide binding]; other site
483179009170	conserved gate region; other site
483179009171	putative PBP binding loops; other site
483179009172	ABC-ATPase subunit interface; other site
483179009173	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179009174	dimer interface [polypeptide binding]; other site
483179009175	conserved gate region; other site
483179009176	putative PBP binding loops; other site
483179009177	ABC-ATPase subunit interface; other site
483179009178	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
483179009179	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
483179009180	Walker A/P-loop; other site
483179009181	ATP binding site [chemical binding]; other site
483179009182	Q-loop/lid; other site
483179009183	ABC transporter signature motif; other site
483179009184	Walker B; other site
483179009185	D-loop; other site
483179009186	H-loop/switch region; other site
483179009187	TOBE domain; Region: TOBE_2; cl01440
483179009188	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
483179009189	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
483179009190	active site
483179009191	metal binding site [ion binding]; metal-binding site
483179009192	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
483179009193	Sulfatase; Region: Sulfatase; cl10460
483179009194	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
483179009195	NMT1-like family; Region: NMT1_2; cl15260
483179009196	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
483179009197	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
483179009198	Walker A/P-loop; other site
483179009199	ATP binding site [chemical binding]; other site
483179009200	Q-loop/lid; other site
483179009201	ABC transporter signature motif; other site
483179009202	Walker B; other site
483179009203	D-loop; other site
483179009204	H-loop/switch region; other site
483179009205	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
483179009206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
483179009207	dimer interface [polypeptide binding]; other site
483179009208	conserved gate region; other site
483179009209	putative PBP binding loops; other site
483179009210	ABC-ATPase subunit interface; other site
483179009211	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
483179009212	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
483179009213	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
483179009214	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
483179009215	N-terminal plug; other site
483179009216	ligand-binding site [chemical binding]; other site
483179009217	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
483179009218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
483179009219	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
483179009220	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
483179009221	putative ligand binding site [chemical binding]; other site
483179009222	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
483179009223	TM-ABC transporter signature motif; other site
483179009224	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
483179009225	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
483179009226	Walker A/P-loop; other site
483179009227	ATP binding site [chemical binding]; other site
483179009228	Q-loop/lid; other site
483179009229	ABC transporter signature motif; other site
483179009230	Walker B; other site
483179009231	D-loop; other site
483179009232	H-loop/switch region; other site
483179009233	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
483179009234	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
483179009235	Walker A/P-loop; other site
483179009236	ATP binding site [chemical binding]; other site
483179009237	Q-loop/lid; other site
483179009238	ABC transporter signature motif; other site
483179009239	Walker B; other site
483179009240	D-loop; other site
483179009241	H-loop/switch region; other site
483179009242	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
483179009243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
483179009244	FeS/SAM binding site; other site
483179009245	HemN C-terminal domain; Region: HemN_C; pfam06969
483179009246	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
483179009247	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
483179009248	P-loop; other site
483179009249	Magnesium ion binding site [ion binding]; other site
483179009250	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
483179009251	P-loop; other site
483179009252	Magnesium ion binding site [ion binding]; other site
483179009253	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
483179009254	ParB-like nuclease domain; Region: ParBc; cl02129