-- dump date   	20120504_135403
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
224914000001	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
224914000002	substrate binding site [chemical binding]; other site
224914000003	active site
224914000004	Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863
224914000005	transcription termination factor Rho; Provisional; Region: rho; PRK09376
224914000006	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
224914000007	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
224914000008	RNA binding site [nucleotide binding]; other site
224914000009	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
224914000010	multimer interface [polypeptide binding]; other site
224914000011	Walker A motif; other site
224914000012	ATP binding site [chemical binding]; other site
224914000013	Walker B motif; other site
224914000014	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
224914000015	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
224914000016	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
224914000017	catalytic residues [active]
224914000018	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
224914000019	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
224914000020	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
224914000021	G1 box; other site
224914000022	GTP/Mg2+ binding site [chemical binding]; other site
224914000023	Switch I region; other site
224914000024	G2 box; other site
224914000025	Switch II region; other site
224914000026	G3 box; other site
224914000027	G4 box; other site
224914000028	G5 box; other site
224914000029	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
224914000030	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
224914000031	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440
224914000032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
224914000033	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
224914000034	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
224914000035	P-loop; other site
224914000036	Magnesium ion binding site [ion binding]; other site
224914000037	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
224914000038	Magnesium ion binding site [ion binding]; other site
224914000039	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
224914000040	ParB-like nuclease domain; Region: ParBc; cl02129
224914000041	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
224914000042	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
224914000043	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
224914000044	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
224914000045	Walker A/P-loop; other site
224914000046	ATP binding site [chemical binding]; other site
224914000047	Q-loop/lid; other site
224914000048	ABC transporter signature motif; other site
224914000049	Walker B; other site
224914000050	D-loop; other site
224914000051	H-loop/switch region; other site
224914000052	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
224914000053	TM-ABC transporter signature motif; other site
224914000054	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
224914000055	zinc binding site [ion binding]; other site
224914000056	putative ligand binding site [chemical binding]; other site
224914000057	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
224914000058	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
224914000059	Protein of unknown function (DUF993); Region: DUF993; pfam06187
224914000060	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224914000061	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224914000062	DNA binding site [nucleotide binding]
224914000063	domain linker motif; other site
224914000064	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
224914000065	putative dimerization interface [polypeptide binding]; other site
224914000066	putative ligand binding site [chemical binding]; other site
224914000067	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914000068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000069	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
224914000070	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
224914000071	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914000072	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914000073	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914000074	substrate binding site [chemical binding]; other site
224914000075	oxyanion hole (OAH) forming residues; other site
224914000076	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914000077	oxyanion hole (OAH) forming residues; other site
224914000078	trimer interface [polypeptide binding]; other site
224914000079	enoyl-CoA hydratase; Validated; Region: PRK08139
224914000080	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914000081	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
224914000082	NAD(P) binding site [chemical binding]; other site
224914000083	catalytic residues [active]
224914000084	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
224914000085	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
224914000086	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
224914000087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000088	NAD(P) binding site [chemical binding]; other site
224914000089	active site
224914000090	choline dehydrogenase; Validated; Region: PRK02106
224914000091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000092	choline dehydrogenase; Validated; Region: PRK02106
224914000093	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
224914000094	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
224914000095	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
224914000096	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
224914000097	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
224914000098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000099	NAD(P) binding site [chemical binding]; other site
224914000100	active site
224914000101	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
224914000102	metal binding site [ion binding]; metal-binding site
224914000103	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
224914000104	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
224914000105	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
224914000106	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000107	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
224914000108	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
224914000109	CPxP  motif; other site
224914000110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
224914000111	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
224914000112	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
224914000113	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
224914000114	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
224914000115	DNA binding site [nucleotide binding]
224914000116	Int/Topo IB signature motif; other site
224914000117	active site
224914000118	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
224914000119	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
224914000120	ADP binding site [chemical binding]; other site
224914000121	magnesium binding site [ion binding]; other site
224914000122	putative shikimate binding site; other site
224914000123	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
224914000124	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
224914000125	active site
224914000126	dimer interface [polypeptide binding]; other site
224914000127	metal binding site [ion binding]; metal-binding site
224914000128	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
224914000129	Domain of unknown function DUF21; Region: DUF21; pfam01595
224914000130	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224914000131	Transporter associated domain; Region: CorC_HlyC; cl08393
224914000132	BolA-like protein; Region: BolA; cl00386
224914000133	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
224914000134	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224914000135	HSP70 interaction site [polypeptide binding]; other site
224914000136	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
224914000137	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
224914000138	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000139	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
224914000140	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
224914000141	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
224914000142	metal ion-dependent adhesion site (MIDAS); other site
224914000143	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224914000144	metal-binding site [ion binding]
224914000145	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
224914000146	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224914000147	metal-binding site [ion binding]
224914000148	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224914000149	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914000150	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
224914000151	DNA binding residues [nucleotide binding]
224914000152	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
224914000153	dimer interface [polypeptide binding]; other site
224914000154	putative metal binding site [ion binding]; other site
224914000155	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
224914000156	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
224914000157	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
224914000158	putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849
224914000159	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
224914000160	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
224914000161	Autotransporter beta-domain; Region: Autotransporter; cl02365
224914000162	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914000163	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224914000164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914000165	active site
224914000166	phosphorylation site [posttranslational modification]
224914000167	intermolecular recognition site; other site
224914000168	dimerization interface [polypeptide binding]; other site
224914000169	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914000170	DNA binding site [nucleotide binding]
224914000171	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224914000172	ligand binding site [chemical binding]; other site
224914000173	flexible hinge region; other site
224914000174	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
224914000175	putative phosphate binding site [ion binding]; other site
224914000176	putative catalytic site [active]
224914000177	active site
224914000178	metal binding site A [ion binding]; metal-binding site
224914000179	DNA binding site [nucleotide binding]
224914000180	putative AP binding site [nucleotide binding]; other site
224914000181	putative metal binding site B [ion binding]; other site
224914000182	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
224914000183	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
224914000184	amphipathic channel; other site
224914000185	Asn-Pro-Ala signature motifs; other site
224914000186	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
224914000187	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000188	Walker A/P-loop; other site
224914000189	ATP binding site [chemical binding]; other site
224914000190	Q-loop/lid; other site
224914000191	ABC transporter signature motif; other site
224914000192	Walker B; other site
224914000193	D-loop; other site
224914000194	H-loop/switch region; other site
224914000195	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
224914000196	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
224914000197	putative active site [active]
224914000198	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
224914000199	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
224914000200	putative acyl-acceptor binding pocket; other site
224914000201	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
224914000202	dimer interface [polypeptide binding]; other site
224914000203	substrate binding site [chemical binding]; other site
224914000204	metal binding sites [ion binding]; metal-binding site
224914000205	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
224914000206	putative active site pocket [active]
224914000207	dimerization interface [polypeptide binding]; other site
224914000208	putative catalytic residue [active]
224914000209	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; cl11537
224914000210	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
224914000211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000212	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
224914000213	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224914000214	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914000215	homodimer interface [polypeptide binding]; other site
224914000216	catalytic residue [active]
224914000217	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914000218	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
224914000219	TIGR02302 family protein; Region: aProt_lowcomp
224914000220	diaminopimelate decarboxylase; Region: lysA; TIGR01048
224914000221	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
224914000222	active site
224914000223	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224914000224	substrate binding site [chemical binding]; other site
224914000225	catalytic residues [active]
224914000226	dimer interface [polypeptide binding]; other site
224914000227	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
224914000228	argininosuccinate lyase; Provisional; Region: PRK00855
224914000229	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
224914000230	active sites [active]
224914000231	tetramer interface [polypeptide binding]; other site
224914000232	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
224914000233	catalytic residues [active]
224914000234	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
224914000235	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
224914000236	short chain dehydrogenase; Validated; Region: PRK06182
224914000237	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
224914000238	NADP binding site [chemical binding]; other site
224914000239	active site
224914000240	steroid binding site; other site
224914000241	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
224914000242	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
224914000243	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
224914000244	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
224914000245	active site
224914000246	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
224914000247	Ligand Binding Site [chemical binding]; other site
224914000248	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
224914000249	Ligand binding site [chemical binding]; other site
224914000250	Electron transfer flavoprotein domain; Region: ETF; pfam01012
224914000251	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
224914000252	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
224914000253	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
224914000254	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
224914000255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914000256	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224914000257	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
224914000258	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
224914000259	dimer interface [polypeptide binding]; other site
224914000260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914000261	catalytic residue [active]
224914000262	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224914000263	Ligand Binding Site [chemical binding]; other site
224914000264	methionine gamma-lyase; Validated; Region: PRK07049
224914000265	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
224914000266	homodimer interface [polypeptide binding]; other site
224914000267	substrate-cofactor binding pocket; other site
224914000268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914000269	catalytic residue [active]
224914000270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914000271	D-galactonate transporter; Region: 2A0114; TIGR00893
224914000272	putative substrate translocation pore; other site
224914000273	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
224914000274	active site
224914000275	homotetramer interface [polypeptide binding]; other site
224914000276	homodimer interface [polypeptide binding]; other site
224914000277	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914000278	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914000279	DNA-binding site [nucleotide binding]; DNA binding site
224914000280	FCD domain; Region: FCD; cl11656
224914000281	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
224914000282	active site
224914000283	homotetramer interface [polypeptide binding]; other site
224914000284	homodimer interface [polypeptide binding]; other site
224914000285	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224914000286	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
224914000287	Walker A/P-loop; other site
224914000288	ATP binding site [chemical binding]; other site
224914000289	Q-loop/lid; other site
224914000290	ABC transporter signature motif; other site
224914000291	Walker B; other site
224914000292	D-loop; other site
224914000293	H-loop/switch region; other site
224914000294	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
224914000295	Aspartase; Region: Aspartase; cd01357
224914000296	active sites [active]
224914000297	tetramer interface [polypeptide binding]; other site
224914000298	Arginase family; Region: Arginase; cl00306
224914000299	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224914000300	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
224914000301	Walker A/P-loop; other site
224914000302	ATP binding site [chemical binding]; other site
224914000303	Q-loop/lid; other site
224914000304	ABC transporter signature motif; other site
224914000305	Walker B; other site
224914000306	D-loop; other site
224914000307	H-loop/switch region; other site
224914000308	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
224914000309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914000310	dimer interface [polypeptide binding]; other site
224914000311	conserved gate region; other site
224914000312	putative PBP binding loops; other site
224914000313	ABC-ATPase subunit interface; other site
224914000314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914000315	dimer interface [polypeptide binding]; other site
224914000316	conserved gate region; other site
224914000317	putative PBP binding loops; other site
224914000318	ABC-ATPase subunit interface; other site
224914000319	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224914000320	membrane-bound complex binding site; other site
224914000321	hinge residues; other site
224914000322	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224914000323	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914000324	Helix-turn-helix domains; Region: HTH; cl00088
224914000325	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224914000326	dimerization interface [polypeptide binding]; other site
224914000327	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
224914000328	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
224914000329	Sulfatase; Region: Sulfatase; cl10460
224914000330	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
224914000331	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
224914000332	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000333	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
224914000334	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000335	nucleotide binding region [chemical binding]; other site
224914000336	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
224914000337	SEC-C motif; Region: SEC-C; pfam02810
224914000338	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
224914000339	PPIC-type PPIASE domain; Region: Rotamase; cl08278
224914000340	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
224914000341	heterotetramer interface [polypeptide binding]; other site
224914000342	active site pocket [active]
224914000343	cleavage site
224914000344	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914000345	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
224914000346	active site
224914000347	8-oxo-dGMP binding site [chemical binding]; other site
224914000348	nudix motif; other site
224914000349	metal binding site [ion binding]; metal-binding site
224914000350	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
224914000351	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
224914000352	Intracellular septation protein A; Region: IspA; cl01098
224914000353	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
224914000354	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
224914000355	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000356	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224914000357	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
224914000358	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914000359	FeS/SAM binding site; other site
224914000360	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
224914000361	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
224914000362	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
224914000363	Protease inhibitor Inh; Region: Inh; pfam02974
224914000364	Predicted ATPase [General function prediction only]; Region: COG1485
224914000365	malate dehydrogenase; Reviewed; Region: PRK06223
224914000366	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
224914000367	NAD(P) binding site [chemical binding]; other site
224914000368	dimer interface [polypeptide binding]; other site
224914000369	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224914000370	substrate binding site [chemical binding]; other site
224914000371	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
224914000372	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914000373	CoA-ligase; Region: Ligase_CoA; pfam00549
224914000374	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
224914000375	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000376	CoA-ligase; Region: Ligase_CoA; cl02894
224914000377	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
224914000378	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
224914000379	TPP-binding site [chemical binding]; other site
224914000380	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
224914000381	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
224914000382	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224914000383	E3 interaction surface; other site
224914000384	lipoyl attachment site [posttranslational modification]; other site
224914000385	e3 binding domain; Region: E3_binding; pfam02817
224914000386	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
224914000387	MAPEG family; Region: MAPEG; cl09190
224914000388	LysE type translocator; Region: LysE; cl00565
224914000389	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
224914000390	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000392	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
224914000393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
224914000394	TraB family; Region: TraB; cl12050
224914000395	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
224914000396	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
224914000397	DNA binding site [nucleotide binding]
224914000398	Int/Topo IB signature motif; other site
224914000399	active site
224914000400	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
224914000401	RimM N-terminal domain; Region: RimM; pfam01782
224914000402	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
224914000403	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
224914000404	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914000405	dimerization interface [polypeptide binding]; other site
224914000406	putative DNA binding site [nucleotide binding]; other site
224914000407	putative Zn2+ binding site [ion binding]; other site
224914000408	NIPSNAP; Region: NIPSNAP; pfam07978
224914000409	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
224914000410	Sodium:solute symporter family; Region: SSF; cl00456
224914000411	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
224914000412	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
224914000413	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
224914000414	substrate binding site [chemical binding]; other site
224914000415	ligand binding site [chemical binding]; other site
224914000416	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914000417	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224914000418	Coenzyme A binding pocket [chemical binding]; other site
224914000419	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
224914000420	Iron-sulfur protein interface; other site
224914000421	proximal quinone binding site [chemical binding]; other site
224914000422	SdhD (CybS) interface [polypeptide binding]; other site
224914000423	proximal heme binding site [chemical binding]; other site
224914000424	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
224914000425	putative SdhC subunit interface [polypeptide binding]; other site
224914000426	putative proximal heme binding site [chemical binding]; other site
224914000427	putative Iron-sulfur protein interface [polypeptide binding]; other site
224914000428	putative proximal quinone binding site; other site
224914000429	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
224914000430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000431	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
224914000432	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
224914000433	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
224914000434	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914000435	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
224914000436	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000437	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
224914000438	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
224914000439	active site
224914000440	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
224914000441	catalytic triad [active]
224914000442	dimer interface [polypeptide binding]; other site
224914000443	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
224914000444	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
224914000445	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000446	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
224914000447	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
224914000448	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914000449	DNA-binding site [nucleotide binding]; DNA binding site
224914000450	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224914000451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914000452	homodimer interface [polypeptide binding]; other site
224914000453	catalytic residue [active]
224914000454	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224914000455	EamA-like transporter family; Region: EamA; cl01037
224914000456	EamA-like transporter family; Region: EamA; cl01037
224914000457	Predicted methyltransferase [General function prediction only]; Region: COG3897
224914000458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914000459	S-adenosylmethionine binding site [chemical binding]; other site
224914000460	EVE domain; Region: EVE; cl00728
224914000461	YCII-related domain; Region: YCII; cl00999
224914000462	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
224914000463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000464	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
224914000465	UGMP family protein; Validated; Region: PRK09604
224914000466	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
224914000467	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
224914000468	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
224914000469	domain interfaces; other site
224914000470	active site
224914000471	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
224914000472	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
224914000473	active site
224914000474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
224914000475	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
224914000476	HemY protein N-terminus; Region: HemY_N; pfam07219
224914000477	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
224914000478	putative metal binding site [ion binding]; other site
224914000479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914000480	putative substrate translocation pore; other site
224914000481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000482	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
224914000483	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
224914000484	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
224914000485	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
224914000486	GSH binding site [chemical binding]; other site
224914000487	catalytic residues [active]
224914000488	Predicted amidohydrolase [General function prediction only]; Region: COG0388
224914000489	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
224914000490	putative active site [active]
224914000491	catalytic triad [active]
224914000492	dimer interface [polypeptide binding]; other site
224914000493	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
224914000494	EamA-like transporter family; Region: EamA; cl01037
224914000495	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
224914000496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914000497	S-adenosylmethionine binding site [chemical binding]; other site
224914000498	aspartate kinase; Reviewed; Region: PRK06635
224914000499	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
224914000500	putative nucleotide binding site [chemical binding]; other site
224914000501	putative catalytic residues [active]
224914000502	putative Mg ion binding site [ion binding]; other site
224914000503	putative aspartate binding site [chemical binding]; other site
224914000504	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
224914000505	putative allosteric regulatory site; other site
224914000506	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
224914000507	putative allosteric regulatory residue; other site
224914000508	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
224914000509	GAF domain; Region: GAF; cl15785
224914000510	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
224914000511	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
224914000512	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
224914000513	peptide chain release factor 1; Validated; Region: prfA; PRK00591
224914000514	RF-1 domain; Region: RF-1; cl02875
224914000515	RF-1 domain; Region: RF-1; cl02875
224914000516	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
224914000517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914000518	S-adenosylmethionine binding site [chemical binding]; other site
224914000519	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
224914000520	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
224914000521	Clp amino terminal domain; Region: Clp_N; pfam02861
224914000522	Clp amino terminal domain; Region: Clp_N; pfam02861
224914000523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914000524	Walker A motif; other site
224914000525	ATP binding site [chemical binding]; other site
224914000526	Walker B motif; other site
224914000527	arginine finger; other site
224914000528	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914000529	Walker A motif; other site
224914000530	ATP binding site [chemical binding]; other site
224914000531	Walker B motif; other site
224914000532	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
224914000533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
224914000534	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914000535	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224914000536	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
224914000537	Integrase core domain; Region: rve; cl01316
224914000538	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
224914000539	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
224914000540	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224914000541	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
224914000542	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914000543	YadA-like C-terminal region; Region: YadA; pfam03895
224914000544	GTPase CgtA; Reviewed; Region: obgE; PRK12299
224914000545	GTP1/OBG; Region: GTP1_OBG; pfam01018
224914000546	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
224914000547	G1 box; other site
224914000548	GTP/Mg2+ binding site [chemical binding]; other site
224914000549	Switch I region; other site
224914000550	G2 box; other site
224914000551	G3 box; other site
224914000552	Switch II region; other site
224914000553	G4 box; other site
224914000554	G5 box; other site
224914000555	gamma-glutamyl kinase; Provisional; Region: PRK05429
224914000556	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
224914000557	nucleotide binding site [chemical binding]; other site
224914000558	homotetrameric interface [polypeptide binding]; other site
224914000559	putative phosphate binding site [ion binding]; other site
224914000560	putative allosteric binding site; other site
224914000561	PUA domain; Region: PUA; cl00607
224914000562	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
224914000563	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
224914000564	putative catalytic cysteine [active]
224914000565	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
224914000566	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
224914000567	active site
224914000568	(T/H)XGH motif; other site
224914000569	Oligomerisation domain; Region: Oligomerisation; cl00519
224914000570	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
224914000571	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
224914000572	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
224914000573	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
224914000574	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
224914000575	protein binding site [polypeptide binding]; other site
224914000576	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
224914000577	Catalytic dyad [active]
224914000578	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
224914000579	putative active site [active]
224914000580	Ap4A binding site [chemical binding]; other site
224914000581	nudix motif; other site
224914000582	putative metal binding site [ion binding]; other site
224914000583	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
224914000584	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914000585	Helix-turn-helix domains; Region: HTH; cl00088
224914000586	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914000587	dimerization interface [polypeptide binding]; other site
224914000588	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
224914000589	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914000590	tetrameric interface [polypeptide binding]; other site
224914000591	NAD binding site [chemical binding]; other site
224914000592	catalytic residues [active]
224914000593	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
224914000594	dimer interface [polypeptide binding]; other site
224914000595	pyridoxal binding site [chemical binding]; other site
224914000596	ATP binding site [chemical binding]; other site
224914000597	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
224914000598	active site clefts [active]
224914000599	zinc binding site [ion binding]; other site
224914000600	dimer interface [polypeptide binding]; other site
224914000601	lytic murein transglycosylase; Region: MltB_2; TIGR02283
224914000602	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
224914000603	signal recognition particle protein; Provisional; Region: PRK10867
224914000604	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
224914000605	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
224914000606	P loop; other site
224914000607	GTP binding site [chemical binding]; other site
224914000608	Signal peptide binding domain; Region: SRP_SPB; pfam02978
224914000609	Chorismate mutase type II; Region: CM_2; cl00693
224914000610	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
224914000611	LemA family; Region: LemA; cl00742
224914000612	Repair protein; Region: Repair_PSII; cl01535
224914000613	Domain of unknown function (DUF477); Region: DUF477; cl01535
224914000614	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
224914000615	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
224914000616	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
224914000617	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
224914000618	purine monophosphate binding site [chemical binding]; other site
224914000619	dimer interface [polypeptide binding]; other site
224914000620	putative catalytic residues [active]
224914000621	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
224914000622	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
224914000623	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
224914000624	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
224914000625	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
224914000626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914000627	S-adenosylmethionine binding site [chemical binding]; other site
224914000628	Peptidase family M48; Region: Peptidase_M48; cl12018
224914000629	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
224914000630	acetyl-CoA synthetase; Provisional; Region: PRK00174
224914000631	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
224914000632	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
224914000633	Usg-like family; Region: Usg; cl11567
224914000634	Predicted membrane protein [Function unknown]; Region: COG1289
224914000635	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
224914000636	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224914000637	catalytic residue [active]
224914000638	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
224914000639	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
224914000640	HIGH motif; other site
224914000641	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224914000642	active site
224914000643	KMSKS motif; other site
224914000644	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
224914000645	tRNA binding surface [nucleotide binding]; other site
224914000646	Predicted secreted (periplasmic) protein (DUF2159); Region: DUF2159; cl11572
224914000647	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
224914000648	active site
224914000649	intersubunit interactions; other site
224914000650	catalytic residue [active]
224914000651	primosome assembly protein PriA; Validated; Region: PRK05580
224914000652	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224914000653	ATP binding site [chemical binding]; other site
224914000654	primosome assembly protein PriA; Validated; Region: PRK05580
224914000655	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000656	Plant ATP synthase F0; Region: YMF19; cl07975
224914000657	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
224914000658	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
224914000659	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
224914000660	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
224914000661	beta subunit interaction interface [polypeptide binding]; other site
224914000662	Walker A motif; other site
224914000663	ATP binding site [chemical binding]; other site
224914000664	Walker B motif; other site
224914000665	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
224914000666	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365
224914000667	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
224914000668	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
224914000669	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
224914000670	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
224914000671	alpha subunit interaction interface [polypeptide binding]; other site
224914000672	Walker A motif; other site
224914000673	ATP binding site [chemical binding]; other site
224914000674	Walker B motif; other site
224914000675	inhibitor binding site; inhibition site
224914000676	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
224914000677	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
224914000678	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
224914000679	Helix-turn-helix domains; Region: HTH; cl00088
224914000680	transcriptional regulator SlyA; Provisional; Region: PRK03573
224914000681	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914000682	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914000683	DNA-binding site [nucleotide binding]; DNA binding site
224914000684	FCD domain; Region: FCD; cl11656
224914000685	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224914000686	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000687	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
224914000688	Proline racemase; Region: Pro_racemase; pfam05544
224914000689	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
224914000690	TM-ABC transporter signature motif; other site
224914000691	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
224914000692	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
224914000693	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
224914000694	TM-ABC transporter signature motif; other site
224914000695	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
224914000696	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
224914000697	Walker A/P-loop; other site
224914000698	ATP binding site [chemical binding]; other site
224914000699	Q-loop/lid; other site
224914000700	ABC transporter signature motif; other site
224914000701	Walker B; other site
224914000702	D-loop; other site
224914000703	H-loop/switch region; other site
224914000704	Uncharacterized conserved protein [Function unknown]; Region: COG3743
224914000705	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
224914000706	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
224914000707	Walker A/P-loop; other site
224914000708	ATP binding site [chemical binding]; other site
224914000709	Q-loop/lid; other site
224914000710	ABC transporter signature motif; other site
224914000711	Walker B; other site
224914000712	D-loop; other site
224914000713	H-loop/switch region; other site
224914000714	leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404
224914000715	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
224914000716	dimerization interface [polypeptide binding]; other site
224914000717	ligand binding site [chemical binding]; other site
224914000718	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914000719	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914000720	pyruvate carboxylase; Reviewed; Region: PRK12999
224914000721	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224914000722	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914000723	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
224914000724	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
224914000725	active site
224914000726	catalytic residues [active]
224914000727	metal binding site [ion binding]; metal-binding site
224914000728	homodimer binding site [polypeptide binding]; other site
224914000729	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
224914000730	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224914000731	carboxyltransferase (CT) interaction site; other site
224914000732	biotinylation site [posttranslational modification]; other site
224914000733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914000734	putative substrate translocation pore; other site
224914000735	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
224914000736	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000737	NAD(P) binding site [chemical binding]; other site
224914000738	active site
224914000739	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
224914000740	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
224914000741	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
224914000742	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
224914000743	substrate binding pocket [chemical binding]; other site
224914000744	chain length determination region; other site
224914000745	substrate-Mg2+ binding site; other site
224914000746	catalytic residues [active]
224914000747	aspartate-rich region 1; other site
224914000748	active site lid residues [active]
224914000749	aspartate-rich region 2; other site
224914000750	Transglycosylase; Region: Transgly; cl07896
224914000751	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
224914000752	Domain of unknown function (DUF336); Region: DUF336; cl01249
224914000753	putative acyltransferase; Provisional; Region: PRK05790
224914000754	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
224914000755	dimer interface [polypeptide binding]; other site
224914000756	active site
224914000757	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000758	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914000759	nucleotide binding region [chemical binding]; other site
224914000760	Superfamily II helicase [General function prediction only]; Region: COG1204
224914000761	ATP-binding site [chemical binding]; other site
224914000762	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224914000763	RNA binding surface [nucleotide binding]; other site
224914000764	Ferredoxin [Energy production and conversion]; Region: COG1146
224914000765	4Fe-4S binding domain; Region: Fer4; cl02805
224914000766	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
224914000767	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
224914000768	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
224914000769	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224914000770	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
224914000771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
224914000772	MOSC domain; Region: MOSC; pfam03473
224914000773	3-alpha domain; Region: 3-alpha; pfam03475
224914000774	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
224914000775	Peptidase family M48; Region: Peptidase_M48; cl12018
224914000776	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
224914000777	ABC-type thiamine tranport system; part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP.  Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins...; Region: ABC_ThiQ_thiamine_transporter; cd03298
224914000778	Walker A/P-loop; other site
224914000779	ATP binding site [chemical binding]; other site
224914000780	Q-loop/lid; other site
224914000781	ABC transporter signature motif; other site
224914000782	Walker B; other site
224914000783	D-loop; other site
224914000784	H-loop/switch region; other site
224914000785	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
224914000786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914000787	dimer interface [polypeptide binding]; other site
224914000788	conserved gate region; other site
224914000789	putative PBP binding loops; other site
224914000790	ABC-ATPase subunit interface; other site
224914000791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914000792	dimer interface [polypeptide binding]; other site
224914000793	conserved gate region; other site
224914000794	putative PBP binding loops; other site
224914000795	ABC-ATPase subunit interface; other site
224914000796	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914000797	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
224914000798	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
224914000799	Thiamine pyrophosphokinase; Region: TPK; cd07995
224914000800	active site
224914000801	dimerization interface [polypeptide binding]; other site
224914000802	thiamine binding site [chemical binding]; other site
224914000803	ABC transporter ATPase component; Reviewed; Region: PRK11147
224914000804	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
224914000805	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
224914000806	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480
224914000807	N-formylglutamate amidohydrolase; Region: FGase; cl01522
224914000808	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
224914000809	pyruvate kinase; Provisional; Region: PRK06247
224914000810	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
224914000811	domain interfaces; other site
224914000812	active site
224914000813	TPR repeat; Region: TPR_11; pfam13414
224914000814	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224914000815	TPR motif; other site
224914000816	binding surface
224914000817	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
224914000818	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
224914000819	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000820	ATP-grasp domain; Region: ATP-grasp_4; cl03087
224914000821	AIR carboxylase; Region: AIRC; cl00310
224914000822	Protein of unknown function (DUF465); Region: DUF465; cl01070
224914000823	Protein of unknown function (DUF465); Region: DUF465; cl01070
224914000824	putative MFS family transporter protein; Provisional; Region: PRK03633
224914000825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914000826	putative substrate translocation pore; other site
224914000827	Protein of unknown function (DUF1192); Region: DUF1192; cl11573
224914000828	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
224914000829	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
224914000830	NAD(P) binding site [chemical binding]; other site
224914000831	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
224914000832	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
224914000833	CoenzymeA binding site [chemical binding]; other site
224914000834	subunit interaction site [polypeptide binding]; other site
224914000835	PHB binding site; other site
224914000836	Predicted transcriptional regulator [Transcription]; Region: COG2378
224914000837	Helix-turn-helix domains; Region: HTH; cl00088
224914000838	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
224914000839	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
224914000840	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
224914000841	Phosphoglycerate kinase; Region: PGK; pfam00162
224914000842	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
224914000843	substrate binding site [chemical binding]; other site
224914000844	hinge regions; other site
224914000845	ADP binding site [chemical binding]; other site
224914000846	catalytic site [active]
224914000847	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267
224914000848	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
224914000849	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
224914000850	transketolase; Reviewed; Region: PRK05899
224914000851	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
224914000852	TPP-binding site [chemical binding]; other site
224914000853	dimer interface [polypeptide binding]; other site
224914000854	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
224914000855	PYR/PP interface [polypeptide binding]; other site
224914000856	dimer interface [polypeptide binding]; other site
224914000857	TPP binding site [chemical binding]; other site
224914000858	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224914000859	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
224914000860	Cell division protein ZapA; Region: ZapA; cl01146
224914000861	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
224914000862	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224914000863	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
224914000864	putative active site [active]
224914000865	metal binding site [ion binding]; metal-binding site
224914000866	homodimer binding site [polypeptide binding]; other site
224914000867	Integral membrane protein TerC family; Region: TerC; cl10468
224914000868	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
224914000869	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
224914000870	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914000871	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914000872	DNA-binding site [nucleotide binding]; DNA binding site
224914000873	FCD domain; Region: FCD; cl11656
224914000874	Domain of unknown function DUF28; Region: DUF28; cl00361
224914000875	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
224914000876	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
224914000877	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914000878	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914000879	Walker A/P-loop; other site
224914000880	ATP binding site [chemical binding]; other site
224914000881	Q-loop/lid; other site
224914000882	ABC transporter signature motif; other site
224914000883	Walker B; other site
224914000884	D-loop; other site
224914000885	H-loop/switch region; other site
224914000886	hypothetical protein; Validated; Region: PRK09039
224914000887	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224914000888	ligand binding site [chemical binding]; other site
224914000889	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
224914000890	active site
224914000891	dimerization interface [polypeptide binding]; other site
224914000892	elongation factor P; Validated; Region: PRK00529
224914000893	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
224914000894	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
224914000895	RNA binding site [nucleotide binding]; other site
224914000896	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
224914000897	RNA binding site [nucleotide binding]; other site
224914000898	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
224914000899	Sel1 repeat; Region: Sel1; cl02723
224914000900	Sel1 repeat; Region: Sel1; cl02723
224914000901	Sel1 repeat; Region: Sel1; cl02723
224914000902	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
224914000903	active site
224914000904	thiamine phosphate binding site [chemical binding]; other site
224914000905	pyrophosphate binding site [ion binding]; other site
224914000906	OpgC protein; Region: OpgC_C; cl00792
224914000907	Acyltransferase family; Region: Acyl_transf_3; pfam01757
224914000908	Protein of unknown function (DUF1465); Region: DUF1465; cl11562
224914000909	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
224914000910	active site
224914000911	putative DNA-binding cleft [nucleotide binding]; other site
224914000912	dimer interface [polypeptide binding]; other site
224914000913	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
224914000914	RuvA N terminal domain; Region: RuvA_N; pfam01330
224914000915	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
224914000916	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
224914000917	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914000918	Walker A motif; other site
224914000919	ATP binding site [chemical binding]; other site
224914000920	Walker B motif; other site
224914000921	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
224914000922	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
224914000923	active site
224914000924	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
224914000925	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
224914000926	translocation protein TolB; Provisional; Region: tolB; PRK05137
224914000927	TolB amino-terminal domain; Region: TolB_N; cl00639
224914000928	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
224914000929	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
224914000930	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
224914000931	putative outer membrane lipoprotein; Provisional; Region: PRK09967
224914000932	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224914000933	ligand binding site [chemical binding]; other site
224914000934	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
224914000935	binding surface
224914000936	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
224914000937	TPR motif; other site
224914000938	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
224914000939	FtsH Extracellular; Region: FtsH_ext; pfam06480
224914000940	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
224914000941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914000942	Walker A motif; other site
224914000943	ATP binding site [chemical binding]; other site
224914000944	Walker B motif; other site
224914000945	arginine finger; other site
224914000946	Peptidase family M41; Region: Peptidase_M41; pfam01434
224914000947	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
224914000948	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
224914000949	active site
224914000950	substrate binding site [chemical binding]; other site
224914000951	metal binding site [ion binding]; metal-binding site
224914000952	Surface antigen; Region: Surface_Ag_2; cl01155
224914000953	Membrane transport protein; Region: Mem_trans; cl09117
224914000954	bile acid transporter; Region: bass; TIGR00841
224914000955	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
224914000956	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914000957	Aminotransferase class-V; Region: Aminotran_5; pfam00266
224914000958	catalytic residue [active]
224914000959	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
224914000960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914000961	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
224914000962	putative L-serine binding site [chemical binding]; other site
224914000963	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
224914000964	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914000965	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
224914000966	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
224914000967	GDP-binding site [chemical binding]; other site
224914000968	ACT binding site; other site
224914000969	IMP binding site; other site
224914000970	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914000971	metabolite-proton symporter; Region: 2A0106; TIGR00883
224914000972	putative substrate translocation pore; other site
224914000973	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
224914000974	diiron binding motif [ion binding]; other site
224914000975	Uncharacterized conserved protein [Function unknown]; Region: COG1633
224914000976	CCC1-related protein family; Region: CCC1_like_1; cd02437
224914000977	TIGR03442 family protein; Region: TIGR03442
224914000978	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
224914000979	putative dimer interface [polypeptide binding]; other site
224914000980	putative active site [active]
224914000981	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224914000982	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914000983	dimerization interface [polypeptide binding]; other site
224914000984	putative DNA binding site [nucleotide binding]; other site
224914000985	putative Zn2+ binding site [ion binding]; other site
224914000986	Helix-turn-helix domains; Region: HTH; cl00088
224914000987	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
224914000988	trimer interface [polypeptide binding]; other site
224914000989	active site
224914000990	macrolide transporter subunit MacA; Provisional; Region: PRK11578
224914000991	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914000992	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224914000993	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
224914000994	Walker A/P-loop; other site
224914000995	ATP binding site [chemical binding]; other site
224914000996	Q-loop/lid; other site
224914000997	ABC transporter signature motif; other site
224914000998	Walker B; other site
224914000999	D-loop; other site
224914001000	H-loop/switch region; other site
224914001001	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224914001002	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224914001003	FtsX-like permease family; Region: FtsX; pfam02687
224914001004	Predicted periplasmic protein [Function unknown]; Region: COG3698
224914001005	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
224914001006	Gram-negative bacterial tonB protein; Region: TonB; cl10048
224914001007	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
224914001008	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
224914001009	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
224914001010	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
224914001011	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
224914001012	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
224914001013	Histidine kinase; Region: HisKA_2; cl06527
224914001014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914001015	ATP binding site [chemical binding]; other site
224914001016	Mg2+ binding site [ion binding]; other site
224914001017	G-X-G motif; other site
224914001018	RNA polymerase sigma factor; Provisional; Region: PRK12516
224914001019	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224914001020	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224914001021	DNA binding residues [nucleotide binding]
224914001022	two-component response regulator; Provisional; Region: PRK09191
224914001023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914001024	active site
224914001025	phosphorylation site [posttranslational modification]
224914001026	intermolecular recognition site; other site
224914001027	dimerization interface [polypeptide binding]; other site
224914001028	PAS fold; Region: PAS_4; pfam08448
224914001029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
224914001030	Histidine kinase; Region: HisKA_2; cl06527
224914001031	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224914001032	metal binding site 2 [ion binding]; metal-binding site
224914001033	putative DNA binding helix; other site
224914001034	metal binding site 1 [ion binding]; metal-binding site
224914001035	dimer interface [polypeptide binding]; other site
224914001036	structural Zn2+ binding site [ion binding]; other site
224914001037	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
224914001038	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224914001039	RNA binding surface [nucleotide binding]; other site
224914001040	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
224914001041	active site
224914001042	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
224914001043	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
224914001044	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224914001045	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224914001046	DNA binding residues [nucleotide binding]
224914001047	putative acetyltransferase; Provisional; Region: PRK03624
224914001048	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914001049	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
224914001050	active site
224914001051	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224914001052	active site
224914001053	HIGH motif; other site
224914001054	nucleotide binding site [chemical binding]; other site
224914001055	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224914001056	active site
224914001057	KMSKS motif; other site
224914001058	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224914001059	helix-hairpin-helix signature motif; other site
224914001060	substrate binding pocket [chemical binding]; other site
224914001061	active site
224914001062	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
224914001063	active site
224914001064	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
224914001065	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
224914001066	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914001067	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
224914001068	tetramerization interface [polypeptide binding]; other site
224914001069	NAD(P) binding site [chemical binding]; other site
224914001070	catalytic residues [active]
224914001071	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224914001072	Helix-turn-helix domains; Region: HTH; cl00088
224914001073	Bacterial transcriptional regulator; Region: IclR; pfam01614
224914001074	choline dehydrogenase; Validated; Region: PRK02106
224914001075	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
224914001076	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
224914001077	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
224914001078	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001079	Walker A/P-loop; other site
224914001080	ATP binding site [chemical binding]; other site
224914001081	Q-loop/lid; other site
224914001082	ABC transporter signature motif; other site
224914001083	Walker B; other site
224914001084	D-loop; other site
224914001085	H-loop/switch region; other site
224914001086	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
224914001087	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914001088	TM-ABC transporter signature motif; other site
224914001089	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
224914001090	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
224914001091	putative ligand binding site [chemical binding]; other site
224914001092	classical (c) SDRs; Region: SDR_c; cd05233
224914001093	NAD(P) binding site [chemical binding]; other site
224914001094	classical (c) SDRs; Region: SDR_c; cd05233
224914001095	active site
224914001096	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
224914001097	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
224914001098	DAK2 domain; Region: Dak2; cl03685
224914001099	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
224914001100	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224914001101	DNA binding residues [nucleotide binding]
224914001102	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
224914001103	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
224914001104	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
224914001105	DAK2 domain; Region: Dak2; cl03685
224914001106	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
224914001107	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
224914001108	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
224914001109	active site
224914001110	nucleophile elbow; other site
224914001111	Surface antigen; Region: Surface_Ag_2; cl01155
224914001112	MarC family integral membrane protein; Region: MarC; cl00919
224914001113	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
224914001114	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
224914001115	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
224914001116	NAD binding site [chemical binding]; other site
224914001117	substrate binding site [chemical binding]; other site
224914001118	homotetramer interface [polypeptide binding]; other site
224914001119	homodimer interface [polypeptide binding]; other site
224914001120	active site
224914001121	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
224914001122	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
224914001123	NAD binding site [chemical binding]; other site
224914001124	substrate binding site [chemical binding]; other site
224914001125	homotetramer interface [polypeptide binding]; other site
224914001126	homodimer interface [polypeptide binding]; other site
224914001127	active site
224914001128	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
224914001129	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
224914001130	tetramer interface [polypeptide binding]; other site
224914001131	active site
224914001132	Mg2+/Mn2+ binding site [ion binding]; other site
224914001133	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
224914001134	Domain of unknown function (DUF955); Region: DUF955; cl01076
224914001135	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
224914001136	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
224914001137	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914001138	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
224914001139	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
224914001140	Walker A/P-loop; other site
224914001141	ATP binding site [chemical binding]; other site
224914001142	Q-loop/lid; other site
224914001143	ABC transporter signature motif; other site
224914001144	Walker B; other site
224914001145	D-loop; other site
224914001146	H-loop/switch region; other site
224914001147	TOBE domain; Region: TOBE_2; cl01440
224914001148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914001149	dimer interface [polypeptide binding]; other site
224914001150	conserved gate region; other site
224914001151	putative PBP binding loops; other site
224914001152	ABC-ATPase subunit interface; other site
224914001153	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
224914001154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914001155	dimer interface [polypeptide binding]; other site
224914001156	conserved gate region; other site
224914001157	putative PBP binding loops; other site
224914001158	ABC-ATPase subunit interface; other site
224914001159	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
224914001160	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
224914001161	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
224914001162	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224914001163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914001164	dimer interface [polypeptide binding]; other site
224914001165	phosphorylation site [posttranslational modification]
224914001166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914001167	ATP binding site [chemical binding]; other site
224914001168	Mg2+ binding site [ion binding]; other site
224914001169	G-X-G motif; other site
224914001170	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
224914001171	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914001172	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001173	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
224914001174	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
224914001175	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
224914001176	inhibitor-cofactor binding pocket; inhibition site
224914001177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914001178	catalytic residue [active]
224914001179	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224914001180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914001181	active site
224914001182	phosphorylation site [posttranslational modification]
224914001183	intermolecular recognition site; other site
224914001184	dimerization interface [polypeptide binding]; other site
224914001185	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914001186	DNA binding site [nucleotide binding]
224914001187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
224914001188	Protein of unknown function (DUF1134); Region: DUF1134; cl02235
224914001189	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914001190	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
224914001191	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
224914001192	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
224914001193	Ligand Binding Site [chemical binding]; other site
224914001194	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
224914001195	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
224914001196	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
224914001197	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914001198	dimerization interface [polypeptide binding]; other site
224914001199	putative DNA binding site [nucleotide binding]; other site
224914001200	putative Zn2+ binding site [ion binding]; other site
224914001201	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
224914001202	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
224914001203	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
224914001204	dipeptide transporter permease DppB; Provisional; Region: PRK10914
224914001205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914001206	dimer interface [polypeptide binding]; other site
224914001207	conserved gate region; other site
224914001208	putative PBP binding loops; other site
224914001209	ABC-ATPase subunit interface; other site
224914001210	dipeptide transporter; Provisional; Region: PRK10913
224914001211	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
224914001212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914001213	dimer interface [polypeptide binding]; other site
224914001214	conserved gate region; other site
224914001215	putative PBP binding loops; other site
224914001216	ABC-ATPase subunit interface; other site
224914001217	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914001218	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
224914001219	Walker A/P-loop; other site
224914001220	ATP binding site [chemical binding]; other site
224914001221	Q-loop/lid; other site
224914001222	ABC transporter signature motif; other site
224914001223	Walker B; other site
224914001224	D-loop; other site
224914001225	H-loop/switch region; other site
224914001226	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914001227	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914001228	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
224914001229	Walker A/P-loop; other site
224914001230	ATP binding site [chemical binding]; other site
224914001231	Q-loop/lid; other site
224914001232	ABC transporter signature motif; other site
224914001233	Walker B; other site
224914001234	D-loop; other site
224914001235	H-loop/switch region; other site
224914001236	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914001237	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
224914001238	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001239	Walker A/P-loop; other site
224914001240	ATP binding site [chemical binding]; other site
224914001241	Q-loop/lid; other site
224914001242	ABC transporter signature motif; other site
224914001243	Walker B; other site
224914001244	D-loop; other site
224914001245	H-loop/switch region; other site
224914001246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914001247	dimer interface [polypeptide binding]; other site
224914001248	conserved gate region; other site
224914001249	putative PBP binding loops; other site
224914001250	ABC-ATPase subunit interface; other site
224914001251	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
224914001252	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
224914001253	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978
224914001254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914001255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914001256	putative substrate translocation pore; other site
224914001257	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
224914001258	Helix-turn-helix domains; Region: HTH; cl00088
224914001259	anthranilate synthase; Provisional; Region: PRK13566
224914001260	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
224914001261	chorismate binding enzyme; Region: Chorismate_bind; cl10555
224914001262	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
224914001263	glutamine binding [chemical binding]; other site
224914001264	catalytic triad [active]
224914001265	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
224914001266	Cation efflux family; Region: Cation_efflux; cl00316
224914001267	2-isopropylmalate synthase; Validated; Region: PRK03739
224914001268	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
224914001269	active site
224914001270	catalytic residues [active]
224914001271	metal binding site [ion binding]; metal-binding site
224914001272	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
224914001273	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224914001274	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
224914001275	active site
224914001276	metal binding site [ion binding]; metal-binding site
224914001277	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
224914001278	nudix motif; other site
224914001279	Surface antigen; Region: Surface_Ag_2; cl01155
224914001280	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
224914001281	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
224914001282	putative dimer interface [polypeptide binding]; other site
224914001283	N-terminal domain interface [polypeptide binding]; other site
224914001284	putative substrate binding pocket (H-site) [chemical binding]; other site
224914001285	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
224914001286	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224914001287	Coenzyme A binding pocket [chemical binding]; other site
224914001288	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
224914001289	Aerotolerance regulator N-terminal; Region: BatA; cl06567
224914001290	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
224914001291	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
224914001292	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
224914001293	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
224914001294	MoxR-like ATPases [General function prediction only]; Region: COG0714
224914001295	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001296	Protein of unknown function (DUF1285); Region: DUF1285; cl01571
224914001297	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
224914001298	putative active site [active]
224914001299	putative CoA binding site [chemical binding]; other site
224914001300	nudix motif; other site
224914001301	metal binding site [ion binding]; metal-binding site
224914001302	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
224914001303	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
224914001304	active site
224914001305	NTP binding site [chemical binding]; other site
224914001306	metal binding triad [ion binding]; metal-binding site
224914001307	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
224914001308	Cupin domain; Region: Cupin_2; cl09118
224914001309	Cupin domain; Region: Cupin_2; cl09118
224914001310	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224914001311	Coenzyme A binding pocket [chemical binding]; other site
224914001312	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
224914001313	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
224914001314	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
224914001315	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224914001316	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914001317	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
224914001318	Walker A/P-loop; other site
224914001319	ATP binding site [chemical binding]; other site
224914001320	Q-loop/lid; other site
224914001321	ABC transporter signature motif; other site
224914001322	Walker B; other site
224914001323	D-loop; other site
224914001324	H-loop/switch region; other site
224914001325	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224914001326	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914001327	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001328	Walker A/P-loop; other site
224914001329	ATP binding site [chemical binding]; other site
224914001330	Q-loop/lid; other site
224914001331	ABC transporter signature motif; other site
224914001332	Walker B; other site
224914001333	D-loop; other site
224914001334	H-loop/switch region; other site
224914001335	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
224914001336	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
224914001337	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
224914001338	[2Fe-2S] cluster binding site [ion binding]; other site
224914001339	cytochrome b; Provisional; Region: CYTB; MTH00191
224914001340	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
224914001341	Qi binding site; other site
224914001342	intrachain domain interface; other site
224914001343	interchain domain interface [polypeptide binding]; other site
224914001344	heme bH binding site [chemical binding]; other site
224914001345	heme bL binding site [chemical binding]; other site
224914001346	Qo binding site; other site
224914001347	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
224914001348	interchain domain interface [polypeptide binding]; other site
224914001349	intrachain domain interface; other site
224914001350	Qi binding site; other site
224914001351	Qo binding site; other site
224914001352	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
224914001353	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
224914001354	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224914001355	active site
224914001356	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
224914001357	putative active site [active]
224914001358	putative catalytic site [active]
224914001359	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
224914001360	putative active site [active]
224914001361	putative catalytic site [active]
224914001362	GTP-binding protein YchF; Reviewed; Region: PRK09601
224914001363	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
224914001364	G1 box; other site
224914001365	GTP/Mg2+ binding site [chemical binding]; other site
224914001366	Switch I region; other site
224914001367	G2 box; other site
224914001368	Switch II region; other site
224914001369	G3 box; other site
224914001370	G4 box; other site
224914001371	G5 box; other site
224914001372	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
224914001373	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
224914001374	putative active site [active]
224914001375	catalytic residue [active]
224914001376	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
224914001377	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
224914001378	5S rRNA interface [nucleotide binding]; other site
224914001379	CTC domain interface [polypeptide binding]; other site
224914001380	L16 interface [polypeptide binding]; other site
224914001381	HerA helicase [Replication, recombination, and repair]; Region: COG0433
224914001382	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
224914001383	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
224914001384	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
224914001385	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
224914001386	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
224914001387	active site
224914001388	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
224914001389	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
224914001390	Uncharacterized conserved protein [Function unknown]; Region: COG1565
224914001391	Uncharacterized ACR, COG1565; Region: DUF185; pfam02636
224914001392	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
224914001393	Membrane fusogenic activity; Region: BMFP; cl01115
224914001394	Family of unknown function (DUF1790); Region: DUF1790; cl02283
224914001395	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
224914001396	dimer interface [polypeptide binding]; other site
224914001397	putative tRNA-binding site [nucleotide binding]; other site
224914001398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
224914001399	dimer interface [polypeptide binding]; other site
224914001400	phosphorylation site [posttranslational modification]
224914001401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914001402	ATP binding site [chemical binding]; other site
224914001403	Mg2+ binding site [ion binding]; other site
224914001404	G-X-G motif; other site
224914001405	osmolarity response regulator; Provisional; Region: ompR; PRK09468
224914001406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914001407	active site
224914001408	phosphorylation site [posttranslational modification]
224914001409	intermolecular recognition site; other site
224914001410	dimerization interface [polypeptide binding]; other site
224914001411	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914001412	DNA binding site [nucleotide binding]
224914001413	Helix-turn-helix domains; Region: HTH; cl00088
224914001414	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
224914001415	BA14K-like protein; Region: BA14K; pfam07886
224914001416	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
224914001417	DNA-binding site [nucleotide binding]; DNA binding site
224914001418	RNA-binding motif; other site
224914001419	Sporulation related domain; Region: SPOR; cl10051
224914001420	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
224914001421	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224914001422	catalytic residue [active]
224914001423	excinuclease ABC subunit B; Provisional; Region: PRK05298
224914001424	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224914001425	ATP binding site [chemical binding]; other site
224914001426	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914001427	nucleotide binding region [chemical binding]; other site
224914001428	ATP-binding site [chemical binding]; other site
224914001429	Ultra-violet resistance protein B; Region: UvrB; pfam12344
224914001430	UvrB/uvrC motif; Region: UVR; pfam02151
224914001431	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
224914001432	Bacterial SH3 domain; Region: SH3_3; cl02551
224914001433	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
224914001434	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
224914001435	Protein of unknown function, DUF486; Region: DUF486; cl01236
224914001436	EamA-like transporter family; Region: EamA; cl01037
224914001437	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
224914001438	EamA-like transporter family; Region: EamA; cl01037
224914001439	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
224914001440	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
224914001441	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
224914001442	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
224914001443	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
224914001444	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224914001445	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914001446	dimerization interface [polypeptide binding]; other site
224914001447	putative DNA binding site [nucleotide binding]; other site
224914001448	putative Zn2+ binding site [ion binding]; other site
224914001449	Helix-turn-helix domains; Region: HTH; cl00088
224914001450	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
224914001451	Cation transport protein; Region: TrkH; cl10514
224914001452	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
224914001453	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001454	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914001455	Helix-turn-helix domains; Region: HTH; cl00088
224914001456	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
224914001457	putative effector binding pocket; other site
224914001458	dimerization interface [polypeptide binding]; other site
224914001459	aspartate aminotransferase; Provisional; Region: PRK05764
224914001460	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224914001461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914001462	homodimer interface [polypeptide binding]; other site
224914001463	catalytic residue [active]
224914001464	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
224914001465	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
224914001466	putative C-terminal domain interface [polypeptide binding]; other site
224914001467	putative GSH binding site (G-site) [chemical binding]; other site
224914001468	putative dimer interface [polypeptide binding]; other site
224914001469	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
224914001470	N-terminal domain interface [polypeptide binding]; other site
224914001471	dimer interface [polypeptide binding]; other site
224914001472	substrate binding pocket (H-site) [chemical binding]; other site
224914001473	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
224914001474	DNA-binding site [nucleotide binding]; DNA binding site
224914001475	RNA-binding motif; other site
224914001476	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
224914001477	nudix motif; other site
224914001478	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
224914001479	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914001480	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
224914001481	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
224914001482	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224914001483	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914001484	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224914001485	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914001486	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
224914001487	IMP binding site; other site
224914001488	dimer interface [polypeptide binding]; other site
224914001489	partial ornithine binding site; other site
224914001490	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
224914001491	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
224914001492	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
224914001493	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
224914001494	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
224914001495	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
224914001496	catalytic site [active]
224914001497	subunit interface [polypeptide binding]; other site
224914001498	GatB domain; Region: GatB_Yqey; cl11497
224914001499	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
224914001500	PhoU domain; Region: PhoU; pfam01895
224914001501	PhoU domain; Region: PhoU; pfam01895
224914001502	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
224914001503	DNA primase; Validated; Region: dnaG; PRK05667
224914001504	CHC2 zinc finger; Region: zf-CHC2; cl15369
224914001505	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
224914001506	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
224914001507	active site
224914001508	metal binding site [ion binding]; metal-binding site
224914001509	interdomain interaction site; other site
224914001510	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
224914001511	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
224914001512	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
224914001513	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
224914001514	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224914001515	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224914001516	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224914001517	DNA binding residues [nucleotide binding]
224914001518	Transcriptional activator HlyU; Region: HlyU; cl02273
224914001519	Flagellin N-methylase; Region: FliB; cl00497
224914001520	Protein of unknown function (DUF541); Region: SIMPL; cl01077
224914001521	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
224914001522	DNA binding site [nucleotide binding]
224914001523	active site
224914001524	Int/Topo IB signature motif; other site
224914001525	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
224914001526	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
224914001527	active site
224914001528	Integral membrane protein TerC family; Region: TerC; cl10468
224914001529	Isochorismatase family; Region: Isochorismatase; pfam00857
224914001530	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
224914001531	catalytic triad [active]
224914001532	metal binding site [ion binding]; metal-binding site
224914001533	conserved cis-peptide bond; other site
224914001534	PhnA protein; Region: PhnA; pfam03831
224914001535	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
224914001536	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
224914001537	FAD binding pocket [chemical binding]; other site
224914001538	FAD binding motif [chemical binding]; other site
224914001539	phosphate binding motif [ion binding]; other site
224914001540	beta-alpha-beta structure motif; other site
224914001541	NAD binding pocket [chemical binding]; other site
224914001542	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224914001543	catalytic loop [active]
224914001544	iron binding site [ion binding]; other site
224914001545	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
224914001546	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
224914001547	[2Fe-2S] cluster binding site [ion binding]; other site
224914001548	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
224914001549	putative alpha subunit interface [polypeptide binding]; other site
224914001550	putative active site [active]
224914001551	putative substrate binding site [chemical binding]; other site
224914001552	Fe binding site [ion binding]; other site
224914001553	Cupin domain; Region: Cupin_2; cl09118
224914001554	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
224914001555	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914001556	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914001557	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
224914001558	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001559	Walker A/P-loop; other site
224914001560	ATP binding site [chemical binding]; other site
224914001561	Q-loop/lid; other site
224914001562	ABC transporter signature motif; other site
224914001563	Walker B; other site
224914001564	D-loop; other site
224914001565	H-loop/switch region; other site
224914001566	ABC transporter; Region: ABC_tran_2; pfam12848
224914001567	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
224914001568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914001569	S-adenosylmethionine binding site [chemical binding]; other site
224914001570	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
224914001571	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
224914001572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914001573	putative substrate translocation pore; other site
224914001574	Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373
224914001575	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914001576	dimerization interface [polypeptide binding]; other site
224914001577	putative DNA binding site [nucleotide binding]; other site
224914001578	putative Zn2+ binding site [ion binding]; other site
224914001579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914001580	S-adenosylmethionine binding site [chemical binding]; other site
224914001581	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
224914001582	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
224914001583	FAD binding site [chemical binding]; other site
224914001584	Membrane transport protein; Region: Mem_trans; cl09117
224914001585	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
224914001586	lytic murein transglycosylase; Region: MltB_2; TIGR02283
224914001587	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
224914001588	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
224914001589	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
224914001590	active site
224914001591	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
224914001592	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
224914001593	putative metal binding site [ion binding]; other site
224914001594	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224914001595	HSP70 interaction site [polypeptide binding]; other site
224914001596	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
224914001597	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
224914001598	amidase catalytic site [active]
224914001599	Zn binding residues [ion binding]; other site
224914001600	substrate binding site [chemical binding]; other site
224914001601	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
224914001602	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
224914001603	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224914001604	catalytic residue [active]
224914001605	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
224914001606	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
224914001607	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
224914001608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001609	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
224914001610	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
224914001611	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224914001612	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
224914001613	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
224914001614	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224914001615	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
224914001616	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224914001617	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
224914001618	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224914001619	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
224914001620	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224914001621	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
224914001622	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
224914001623	Mg++ binding site [ion binding]; other site
224914001624	putative catalytic motif [active]
224914001625	putative substrate binding site [chemical binding]; other site
224914001626	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
224914001627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001628	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224914001629	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
224914001630	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
224914001631	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
224914001632	active site
224914001633	homodimer interface [polypeptide binding]; other site
224914001634	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
224914001635	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224914001636	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
224914001637	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224914001638	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
224914001639	FAD binding domain; Region: FAD_binding_4; pfam01565
224914001640	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
224914001641	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
224914001642	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
224914001643	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914001644	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
224914001645	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
224914001646	Cell division protein FtsQ; Region: FtsQ; pfam03799
224914001647	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
224914001648	Cell division protein FtsA; Region: FtsA; cl11496
224914001649	Cell division protein FtsA; Region: FtsA; cl11496
224914001650	cell division protein FtsZ; Validated; Region: PRK09330
224914001651	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
224914001652	nucleotide binding site [chemical binding]; other site
224914001653	SulA interaction site; other site
224914001654	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
224914001655	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
224914001656	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
224914001657	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
224914001658	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
224914001659	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
224914001660	Walker A/P-loop; other site
224914001661	ATP binding site [chemical binding]; other site
224914001662	Q-loop/lid; other site
224914001663	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
224914001664	ABC transporter signature motif; other site
224914001665	Walker B; other site
224914001666	D-loop; other site
224914001667	H-loop/switch region; other site
224914001668	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
224914001669	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
224914001670	nucleotide binding pocket [chemical binding]; other site
224914001671	K-X-D-G motif; other site
224914001672	catalytic site [active]
224914001673	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
224914001674	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
224914001675	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
224914001676	Dimer interface [polypeptide binding]; other site
224914001677	BRCT sequence motif; other site
224914001678	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
224914001679	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
224914001680	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
224914001681	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
224914001682	active site
224914001683	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
224914001684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914001685	S-adenosylmethionine binding site [chemical binding]; other site
224914001686	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
224914001687	Cu(I) binding site [ion binding]; other site
224914001688	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
224914001689	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
224914001690	trimer interface [polypeptide binding]; other site
224914001691	active site
224914001692	substrate binding site [chemical binding]; other site
224914001693	CoA binding site [chemical binding]; other site
224914001694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
224914001695	CreA protein; Region: CreA; pfam05981
224914001696	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
224914001697	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001698	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
224914001699	active site
224914001700	ATP binding site [chemical binding]; other site
224914001701	acetate-CoA ligase; Region: PLN02654
224914001702	Domain of unknown function (DUF336); Region: DUF336; cl01249
224914001703	D-lactate dehydrogenase [cytochrome]; Region: PLN02805
224914001704	FAD binding domain; Region: FAD_binding_4; pfam01565
224914001705	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
224914001706	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
224914001707	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
224914001708	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
224914001709	Stringent starvation protein B; Region: SspB; cl01120
224914001710	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224914001711	Helix-turn-helix domains; Region: HTH; cl00088
224914001712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914001713	putative substrate translocation pore; other site
224914001714	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
224914001715	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
224914001716	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
224914001717	dimerization interface [polypeptide binding]; other site
224914001718	active site
224914001719	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
224914001720	folate binding site [chemical binding]; other site
224914001721	NADP+ binding site [chemical binding]; other site
224914001722	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
224914001723	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
224914001724	HflK protein; Region: hflK; TIGR01933
224914001725	FtsH protease regulator HflC; Provisional; Region: PRK11029
224914001726	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
224914001727	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
224914001728	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
224914001729	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
224914001730	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224914001731	protein binding site [polypeptide binding]; other site
224914001732	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224914001733	protein binding site [polypeptide binding]; other site
224914001734	Predicted flavoproteins [General function prediction only]; Region: COG2081
224914001735	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001736	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
224914001737	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914001738	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914001739	motif II; other site
224914001740	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
224914001741	IPP transferase; Region: IPPT; cl00403
224914001742	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
224914001743	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
224914001744	PYR/PP interface [polypeptide binding]; other site
224914001745	dimer interface [polypeptide binding]; other site
224914001746	TPP binding site [chemical binding]; other site
224914001747	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
224914001748	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
224914001749	TPP-binding site [chemical binding]; other site
224914001750	dimer interface [polypeptide binding]; other site
224914001751	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
224914001752	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
224914001753	putative valine binding site [chemical binding]; other site
224914001754	dimer interface [polypeptide binding]; other site
224914001755	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
224914001756	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001757	Family description; Region: UvrD_C_2; cl15862
224914001758	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
224914001759	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
224914001760	active site
224914001761	hydrophilic channel; other site
224914001762	dimerization interface [polypeptide binding]; other site
224914001763	catalytic residues [active]
224914001764	active site lid [active]
224914001765	Amino acid permease; Region: AA_permease; cl00524
224914001766	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224914001767	Helix-turn-helix domains; Region: HTH; cl00088
224914001768	ketol-acid reductoisomerase; Provisional; Region: PRK05479
224914001769	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001770	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
224914001771	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
224914001772	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224914001773	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914001774	homodimer interface [polypeptide binding]; other site
224914001775	catalytic residue [active]
224914001776	BA14K-like protein; Region: BA14K; pfam07886
224914001777	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
224914001778	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
224914001779	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
224914001780	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
224914001781	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
224914001782	CrcB-like protein; Region: CRCB; cl09114
224914001783	CrcB-like protein; Region: CRCB; cl09114
224914001784	Domain of unknown function DUF302; Region: DUF302; cl01364
224914001785	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001786	ABC transporter signature motif; other site
224914001787	Walker B; other site
224914001788	D-loop; other site
224914001789	H-loop/switch region; other site
224914001790	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001791	Walker A/P-loop; other site
224914001792	ATP binding site [chemical binding]; other site
224914001793	Q-loop/lid; other site
224914001794	Cobalt transport protein; Region: CbiQ; cl00463
224914001795	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
224914001796	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
224914001797	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
224914001798	Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
224914001799	Urea transporter; Region: UT; cl01829
224914001800	UreD urease accessory protein; Region: UreD; cl00530
224914001801	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001802	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
224914001803	UreF; Region: UreF; pfam01730
224914001804	urease accessory protein UreE; Provisional; Region: ureE; PRK14711
224914001805	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
224914001806	dimer interface [polypeptide binding]; other site
224914001807	catalytic residues [active]
224914001808	urease subunit alpha; Reviewed; Region: ureC; PRK13309
224914001809	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
224914001810	subunit interactions [polypeptide binding]; other site
224914001811	active site
224914001812	flap region; other site
224914001813	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
224914001814	alpha-beta subunit interface [polypeptide binding]; other site
224914001815	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
224914001816	alpha-gamma subunit interface [polypeptide binding]; other site
224914001817	beta-gamma subunit interface [polypeptide binding]; other site
224914001818	Uncharacterised BCR, COG1649; Region: DUF187; cl15398
224914001819	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914001820	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
224914001821	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
224914001822	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001823	ABC transporter signature motif; other site
224914001824	Walker B; other site
224914001825	D-loop; other site
224914001826	H-loop/switch region; other site
224914001827	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
224914001828	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001829	Walker A/P-loop; other site
224914001830	ATP binding site [chemical binding]; other site
224914001831	Q-loop/lid; other site
224914001832	ABC transporter signature motif; other site
224914001833	Walker B; other site
224914001834	D-loop; other site
224914001835	H-loop/switch region; other site
224914001836	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
224914001837	ABC-2 type transporter; Region: ABC2_membrane; cl11417
224914001838	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
224914001839	ABC-2 type transporter; Region: ABC2_membrane; cl11417
224914001840	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
224914001841	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
224914001842	N-terminal plug; other site
224914001843	ligand-binding site [chemical binding]; other site
224914001844	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
224914001845	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
224914001846	intersubunit interface [polypeptide binding]; other site
224914001847	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224914001848	ABC-ATPase subunit  interface; other site
224914001849	dimer interface [polypeptide binding]; other site
224914001850	putative PBP binding regions; other site
224914001851	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
224914001852	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
224914001853	Walker A/P-loop; other site
224914001854	ATP binding site [chemical binding]; other site
224914001855	Q-loop/lid; other site
224914001856	ABC transporter signature motif; other site
224914001857	Walker B; other site
224914001858	D-loop; other site
224914001859	H-loop/switch region; other site
224914001860	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914001861	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001862	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
224914001863	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914001864	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914001865	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914001866	TM-ABC transporter signature motif; other site
224914001867	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224914001868	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
224914001869	Walker A/P-loop; other site
224914001870	ATP binding site [chemical binding]; other site
224914001871	Q-loop/lid; other site
224914001872	ABC transporter signature motif; other site
224914001873	Walker B; other site
224914001874	D-loop; other site
224914001875	H-loop/switch region; other site
224914001876	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
224914001877	classical (c) SDRs; Region: SDR_c; cd05233
224914001878	NAD(P) binding site [chemical binding]; other site
224914001879	active site
224914001880	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
224914001881	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302
224914001882	Ca2+ binding site [ion binding]; other site
224914001883	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
224914001884	Integral membrane protein TerC family; Region: TerC; cl10468
224914001885	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224914001886	Transporter associated domain; Region: CorC_HlyC; cl08393
224914001887	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914001888	sulfate ABC transporter, permease protein CysT; Region: permease_CysT; TIGR02139
224914001889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914001890	dimer interface [polypeptide binding]; other site
224914001891	conserved gate region; other site
224914001892	putative PBP binding loops; other site
224914001893	ABC-ATPase subunit interface; other site
224914001894	sulfate transport protein; Provisional; Region: cysT; CHL00187
224914001895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914001896	dimer interface [polypeptide binding]; other site
224914001897	conserved gate region; other site
224914001898	putative PBP binding loops; other site
224914001899	ABC-ATPase subunit interface; other site
224914001900	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914001901	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914001902	Predicted integral membrane protein [Function unknown]; Region: COG0392
224914001903	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
224914001904	putative cation:proton antiport protein; Provisional; Region: PRK10669
224914001905	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
224914001906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001907	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023
224914001908	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
224914001909	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
224914001910	Protein export membrane protein; Region: SecD_SecF; cl14618
224914001911	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
224914001912	Protein export membrane protein; Region: SecD_SecF; cl14618
224914001913	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
224914001914	Mechanosensitive ion channel; Region: MS_channel; pfam00924
224914001915	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224914001916	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001917	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
224914001918	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
224914001919	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
224914001920	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
224914001921	conserved cys residue [active]
224914001922	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914001923	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914001924	Helix-turn-helix domains; Region: HTH; cl00088
224914001925	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914001926	dimerization interface [polypeptide binding]; other site
224914001927	Entericidin EcnA/B family; Region: Entericidin; cl02322
224914001928	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914001929	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
224914001930	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224914001931	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
224914001932	substrate binding pocket [chemical binding]; other site
224914001933	FAD binding site [chemical binding]; other site
224914001934	catalytic base [active]
224914001935	cobyric acid synthase; Provisional; Region: PRK00784
224914001936	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001937	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001938	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
224914001939	catalytic triad [active]
224914001940	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
224914001941	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
224914001942	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
224914001943	homotrimer interface [polypeptide binding]; other site
224914001944	Walker A motif; other site
224914001945	GTP binding site [chemical binding]; other site
224914001946	Walker B motif; other site
224914001947	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
224914001948	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914001949	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
224914001950	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
224914001951	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
224914001952	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
224914001953	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
224914001954	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
224914001955	homodimer interface [polypeptide binding]; other site
224914001956	Walker A motif; other site
224914001957	ATP binding site [chemical binding]; other site
224914001958	hydroxycobalamin binding site [chemical binding]; other site
224914001959	Walker B motif; other site
224914001960	EamA-like transporter family; Region: EamA; cl01037
224914001961	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
224914001962	tellurium resistance terB-like protein; Region: terB_like; cd07177
224914001963	metal binding site [ion binding]; metal-binding site
224914001964	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
224914001965	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
224914001966	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
224914001967	CbiD; Region: CbiD; cl00828
224914001968	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
224914001969	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
224914001970	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
224914001971	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
224914001972	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
224914001973	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224914001974	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914001975	homodimer interface [polypeptide binding]; other site
224914001976	catalytic residue [active]
224914001977	CobD/Cbib protein; Region: CobD_Cbib; cl00561
224914001978	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
224914001979	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
224914001980	ligand binding site [chemical binding]; other site
224914001981	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914001982	Flavin Reductases; Region: FlaRed; cl00801
224914001983	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
224914001984	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
224914001985	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
224914001986	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
224914001987	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
224914001988	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
224914001989	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
224914001990	Precorrin-8X methylmutase; Region: CbiC; pfam02570
224914001991	precorrin-3B synthase; Region: CobG; TIGR02435
224914001992	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224914001993	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224914001994	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
224914001995	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
224914001996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914001997	Surface antigen; Region: Surface_Ag_2; cl01155
224914001998	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
224914001999	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
224914002000	MPN+ (JAMM) motif; other site
224914002001	Zinc-binding site [ion binding]; other site
224914002002	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
224914002003	active site
224914002004	Sugar fermentation stimulation protein; Region: SfsA; cl00647
224914002005	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
224914002006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
224914002007	Peptidase M15; Region: Peptidase_M15_3; cl01194
224914002008	aminotransferase; Validated; Region: PRK09148
224914002009	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224914002010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914002011	homodimer interface [polypeptide binding]; other site
224914002012	catalytic residue [active]
224914002013	homoserine dehydrogenase; Provisional; Region: PRK06349
224914002014	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002015	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
224914002016	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
224914002017	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
224914002018	putative active site [active]
224914002019	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
224914002020	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
224914002021	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914002022	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
224914002023	DHH family; Region: DHH; pfam01368
224914002024	Tim44-like domain; Region: Tim44; cl09208
224914002025	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914002026	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
224914002027	dimer interface [polypeptide binding]; other site
224914002028	active site
224914002029	metal binding site [ion binding]; metal-binding site
224914002030	glutathione binding site [chemical binding]; other site
224914002031	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
224914002032	DNA-binding site [nucleotide binding]; DNA binding site
224914002033	RNA-binding motif; other site
224914002034	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
224914002035	DNA-binding site [nucleotide binding]; DNA binding site
224914002036	RNA-binding motif; other site
224914002037	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
224914002038	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914002039	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224914002040	serine acetyltransferase; Provisional; Region: cysE; PRK11132
224914002041	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
224914002042	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
224914002043	trimer interface [polypeptide binding]; other site
224914002044	active site
224914002045	substrate binding site [chemical binding]; other site
224914002046	CoA binding site [chemical binding]; other site
224914002047	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
224914002048	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
224914002049	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
224914002050	trimer interface [polypeptide binding]; other site
224914002051	putative metal binding site [ion binding]; other site
224914002052	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
224914002053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
224914002054	PAS domain; Region: PAS_5; pfam07310
224914002055	Rhomboid family; Region: Rhomboid; cl11446
224914002056	FOG: CBS domain [General function prediction only]; Region: COG0517
224914002057	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
224914002058	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
224914002059	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
224914002060	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
224914002061	elongation factor Tu; Reviewed; Region: PRK00049
224914002062	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
224914002063	G1 box; other site
224914002064	GEF interaction site [polypeptide binding]; other site
224914002065	GTP/Mg2+ binding site [chemical binding]; other site
224914002066	Switch I region; other site
224914002067	G2 box; other site
224914002068	G3 box; other site
224914002069	Switch II region; other site
224914002070	G4 box; other site
224914002071	G5 box; other site
224914002072	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
224914002073	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
224914002074	Antibiotic Binding Site [chemical binding]; other site
224914002075	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
224914002076	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
224914002077	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
224914002078	putative homodimer interface [polypeptide binding]; other site
224914002079	KOW motif; Region: KOW; cl00354
224914002080	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
224914002081	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
224914002082	23S rRNA interface [nucleotide binding]; other site
224914002083	L7/L12 interface [polypeptide binding]; other site
224914002084	putative thiostrepton binding site; other site
224914002085	L25 interface [polypeptide binding]; other site
224914002086	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
224914002087	mRNA/rRNA interface [nucleotide binding]; other site
224914002088	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
224914002089	23S rRNA interface [nucleotide binding]; other site
224914002090	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
224914002091	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
224914002092	L11 interface [polypeptide binding]; other site
224914002093	putative EF-Tu interaction site [polypeptide binding]; other site
224914002094	putative EF-G interaction site [polypeptide binding]; other site
224914002095	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
224914002096	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
224914002097	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
224914002098	RPB11 interaction site [polypeptide binding]; other site
224914002099	RPB12 interaction site [polypeptide binding]; other site
224914002100	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
224914002101	RPB1 interaction site [polypeptide binding]; other site
224914002102	RPB11 interaction site [polypeptide binding]; other site
224914002103	RPB10 interaction site [polypeptide binding]; other site
224914002104	RPB3 interaction site [polypeptide binding]; other site
224914002105	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
224914002106	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
224914002107	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
224914002108	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
224914002109	DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388
224914002110	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
224914002111	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
224914002112	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
224914002113	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
224914002114	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
224914002115	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
224914002116	DNA binding site [nucleotide binding]
224914002117	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
224914002118	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
224914002119	S17 interaction site [polypeptide binding]; other site
224914002120	S8 interaction site; other site
224914002121	16S rRNA interaction site [nucleotide binding]; other site
224914002122	streptomycin interaction site [chemical binding]; other site
224914002123	23S rRNA interaction site [nucleotide binding]; other site
224914002124	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
224914002125	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
224914002126	elongation factor G; Reviewed; Region: PRK00007
224914002127	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886
224914002128	G1 box; other site
224914002129	putative GEF interaction site [polypeptide binding]; other site
224914002130	GTP/Mg2+ binding site [chemical binding]; other site
224914002131	Switch I region; other site
224914002132	G2 box; other site
224914002133	G3 box; other site
224914002134	Switch II region; other site
224914002135	G4 box; other site
224914002136	G5 box; other site
224914002137	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
224914002138	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
224914002139	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
224914002140	elongation factor Tu; Reviewed; Region: PRK00049
224914002141	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
224914002142	G1 box; other site
224914002143	GEF interaction site [polypeptide binding]; other site
224914002144	GTP/Mg2+ binding site [chemical binding]; other site
224914002145	Switch I region; other site
224914002146	G2 box; other site
224914002147	G3 box; other site
224914002148	Switch II region; other site
224914002149	G4 box; other site
224914002150	G5 box; other site
224914002151	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
224914002152	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
224914002153	Antibiotic Binding Site [chemical binding]; other site
224914002154	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
224914002155	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
224914002156	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
224914002157	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
224914002158	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
224914002159	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
224914002160	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
224914002161	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
224914002162	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
224914002163	putative translocon binding site; other site
224914002164	protein-rRNA interface [nucleotide binding]; other site
224914002165	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
224914002166	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
224914002167	G-X-X-G motif; other site
224914002168	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
224914002169	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
224914002170	23S rRNA interface [nucleotide binding]; other site
224914002171	5S rRNA interface [nucleotide binding]; other site
224914002172	putative antibiotic binding site [chemical binding]; other site
224914002173	L25 interface [polypeptide binding]; other site
224914002174	L27 interface [polypeptide binding]; other site
224914002175	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
224914002176	23S rRNA interface [nucleotide binding]; other site
224914002177	putative translocon interaction site; other site
224914002178	signal recognition particle (SRP54) interaction site; other site
224914002179	L23 interface [polypeptide binding]; other site
224914002180	trigger factor interaction site; other site
224914002181	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
224914002182	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
224914002183	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
224914002184	KOW motif; Region: KOW; cl00354
224914002185	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
224914002186	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
224914002187	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
224914002188	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
224914002189	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
224914002190	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
224914002191	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
224914002192	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
224914002193	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
224914002194	5S rRNA interface [nucleotide binding]; other site
224914002195	23S rRNA interface [nucleotide binding]; other site
224914002196	L5 interface [polypeptide binding]; other site
224914002197	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
224914002198	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
224914002199	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
224914002200	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
224914002201	23S rRNA binding site [nucleotide binding]; other site
224914002202	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
224914002203	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
224914002204	SecY translocase; Region: SecY; pfam00344
224914002205	adenylate kinase; Reviewed; Region: adk; PRK00279
224914002206	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
224914002207	AMP-binding site [chemical binding]; other site
224914002208	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
224914002209	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
224914002210	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
224914002211	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
224914002212	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
224914002213	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
224914002214	alphaNTD homodimer interface [polypeptide binding]; other site
224914002215	alphaNTD - beta interaction site [polypeptide binding]; other site
224914002216	alphaNTD - beta' interaction site [polypeptide binding]; other site
224914002217	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
224914002218	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
224914002219	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
224914002220	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
224914002221	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224914002222	protein binding site [polypeptide binding]; other site
224914002223	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224914002224	protein binding site [polypeptide binding]; other site
224914002225	recombination factor protein RarA; Reviewed; Region: PRK13342
224914002226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914002227	Walker A motif; other site
224914002228	ATP binding site [chemical binding]; other site
224914002229	Walker B motif; other site
224914002230	arginine finger; other site
224914002231	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
224914002232	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
224914002233	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224914002234	catalytic residue [active]
224914002235	putative outer membrane lipoprotein; Provisional; Region: PRK10510
224914002236	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224914002237	ligand binding site [chemical binding]; other site
224914002238	recombinase A; Provisional; Region: recA; PRK09354
224914002239	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
224914002240	hexamer interface [polypeptide binding]; other site
224914002241	Walker A motif; other site
224914002242	ATP binding site [chemical binding]; other site
224914002243	Walker B motif; other site
224914002244	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
224914002245	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
224914002246	motif 1; other site
224914002247	active site
224914002248	motif 2; other site
224914002249	motif 3; other site
224914002250	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
224914002251	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
224914002252	dimer interface [polypeptide binding]; other site
224914002253	Alkaline phosphatase homologues; Region: alkPPc; smart00098
224914002254	active site
224914002255	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
224914002256	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
224914002257	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
224914002258	conserved cys residue [active]
224914002259	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
224914002260	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
224914002261	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
224914002262	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
224914002263	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
224914002264	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
224914002265	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
224914002266	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
224914002267	active site
224914002268	substrate binding site [chemical binding]; other site
224914002269	coenzyme B12 binding site [chemical binding]; other site
224914002270	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
224914002271	B12 binding site [chemical binding]; other site
224914002272	cobalt ligand [ion binding]; other site
224914002273	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
224914002274	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224914002275	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914002276	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
224914002277	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224914002278	carboxyltransferase (CT) interaction site; other site
224914002279	biotinylation site [posttranslational modification]; other site
224914002280	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
224914002281	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
224914002282	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
224914002283	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224914002284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224914002285	non-specific DNA binding site [nucleotide binding]; other site
224914002286	salt bridge; other site
224914002287	sequence-specific DNA binding site [nucleotide binding]; other site
224914002288	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
224914002289	Domain of unknown function (DUF955); Region: DUF955; cl01076
224914002290	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
224914002291	Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561
224914002292	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
224914002293	CsbD-like; Region: CsbD; cl01888
224914002294	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224914002295	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
224914002296	DNA binding residues [nucleotide binding]
224914002297	putative dimer interface [polypeptide binding]; other site
224914002298	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
224914002299	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
224914002300	putative active site [active]
224914002301	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
224914002302	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
224914002303	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
224914002304	Protein of unknown function (DUF1489); Region: DUF1489; cl11570
224914002305	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
224914002306	Sporulation related domain; Region: SPOR; cl10051
224914002307	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
224914002308	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
224914002309	Clp amino terminal domain; Region: Clp_N; pfam02861
224914002310	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914002311	Walker A motif; other site
224914002312	ATP binding site [chemical binding]; other site
224914002313	Walker B motif; other site
224914002314	arginine finger; other site
224914002315	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914002316	Walker A motif; other site
224914002317	ATP binding site [chemical binding]; other site
224914002318	Walker B motif; other site
224914002319	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
224914002320	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
224914002321	HIT family signature motif; other site
224914002322	catalytic residue [active]
224914002323	FemAB family; Region: FemAB; cl11444
224914002324	Protein of unknown function, DUF482; Region: DUF482; pfam04339
224914002325	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
224914002326	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
224914002327	putative active site [active]
224914002328	catalytic site [active]
224914002329	putative metal binding site [ion binding]; other site
224914002330	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
224914002331	homotrimer interaction site [polypeptide binding]; other site
224914002332	putative active site [active]
224914002333	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
224914002334	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
224914002335	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
224914002336	rRNA interaction site [nucleotide binding]; other site
224914002337	S8 interaction site; other site
224914002338	putative laminin-1 binding site; other site
224914002339	elongation factor Ts; Provisional; Region: tsf; PRK09377
224914002340	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
224914002341	Elongation factor TS; Region: EF_TS; pfam00889
224914002342	Elongation factor TS; Region: EF_TS; pfam00889
224914002343	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
224914002344	putative nucleotide binding site [chemical binding]; other site
224914002345	uridine monophosphate binding site [chemical binding]; other site
224914002346	homohexameric interface [polypeptide binding]; other site
224914002347	ribosome recycling factor; Reviewed; Region: frr; PRK00083
224914002348	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
224914002349	hinge region; other site
224914002350	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
224914002351	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
224914002352	catalytic residue [active]
224914002353	putative FPP diphosphate  binding site; other site
224914002354	putative FPP binding hydrophobic cleft; other site
224914002355	dimer interface [polypeptide binding]; other site
224914002356	putative IPP diphosphate binding site; other site
224914002357	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
224914002358	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
224914002359	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
224914002360	active site
224914002361	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
224914002362	protein binding site [polypeptide binding]; other site
224914002363	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
224914002364	putative substrate binding region [chemical binding]; other site
224914002365	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
224914002366	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
224914002367	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
224914002368	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
224914002369	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
224914002370	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
224914002371	Surface antigen; Region: Bac_surface_Ag; cl03097
224914002372	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
224914002373	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
224914002374	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
224914002375	trimer interface [polypeptide binding]; other site
224914002376	active site
224914002377	UDP-GlcNAc binding site [chemical binding]; other site
224914002378	lipid binding site [chemical binding]; lipid-binding site
224914002379	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
224914002380	acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Region: lipid_A_lpxA; TIGR01852
224914002381	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
224914002382	active site
224914002383	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
224914002384	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
224914002385	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224914002386	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
224914002387	dimer interface [polypeptide binding]; other site
224914002388	Citrate synthase; Region: Citrate_synt; pfam00285
224914002389	active site
224914002390	citrylCoA binding site [chemical binding]; other site
224914002391	NADH binding [chemical binding]; other site
224914002392	cationic pore residues; other site
224914002393	oxalacetate/citrate binding site [chemical binding]; other site
224914002394	coenzyme A binding site [chemical binding]; other site
224914002395	catalytic triad [active]
224914002396	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
224914002397	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224914002398	active site
224914002399	HIGH motif; other site
224914002400	nucleotide binding site [chemical binding]; other site
224914002401	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
224914002402	active site
224914002403	KMSKS motif; other site
224914002404	Competence protein; Region: Competence; cl00471
224914002405	LexA repressor; Validated; Region: PRK00215
224914002406	Helix-turn-helix domains; Region: HTH; cl00088
224914002407	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
224914002408	Catalytic site [active]
224914002409	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
224914002410	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
224914002411	dimer interface [polypeptide binding]; other site
224914002412	putative functional site; other site
224914002413	putative MPT binding site; other site
224914002414	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
224914002415	trimer interface [polypeptide binding]; other site
224914002416	dimer interface [polypeptide binding]; other site
224914002417	putative active site [active]
224914002418	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
224914002419	active site
224914002420	ribulose/triose binding site [chemical binding]; other site
224914002421	phosphate binding site [ion binding]; other site
224914002422	substrate (anthranilate) binding pocket [chemical binding]; other site
224914002423	product (indole) binding pocket [chemical binding]; other site
224914002424	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
224914002425	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
224914002426	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
224914002427	SurA N-terminal domain; Region: SurA_N_3; cl07813
224914002428	PPIC-type PPIASE domain; Region: Rotamase; cl08278
224914002429	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
224914002430	substrate binding site [chemical binding]; other site
224914002431	dimer interface [polypeptide binding]; other site
224914002432	catalytic triad [active]
224914002433	Preprotein translocase SecG subunit; Region: SecG; cl09123
224914002434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
224914002435	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914002436	CTP synthetase; Validated; Region: pyrG; PRK05380
224914002437	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
224914002438	Catalytic site [active]
224914002439	active site
224914002440	UTP binding site [chemical binding]; other site
224914002441	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
224914002442	active site
224914002443	putative oxyanion hole; other site
224914002444	catalytic triad [active]
224914002445	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
224914002446	NeuB family; Region: NeuB; cl00496
224914002447	enolase; Provisional; Region: eno; PRK00077
224914002448	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
224914002449	dimer interface [polypeptide binding]; other site
224914002450	metal binding site [ion binding]; metal-binding site
224914002451	substrate binding pocket [chemical binding]; other site
224914002452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914002453	S-adenosylmethionine binding site [chemical binding]; other site
224914002454	Septum formation initiator; Region: DivIC; cl11433
224914002455	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
224914002456	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
224914002457	tetramer interface [polypeptide binding]; other site
224914002458	TPP-binding site [chemical binding]; other site
224914002459	heterodimer interface [polypeptide binding]; other site
224914002460	phosphorylation loop region [posttranslational modification]
224914002461	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
224914002462	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224914002463	E3 interaction surface; other site
224914002464	lipoyl attachment site [posttranslational modification]; other site
224914002465	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
224914002466	alpha subunit interface [polypeptide binding]; other site
224914002467	TPP binding site [chemical binding]; other site
224914002468	heterodimer interface [polypeptide binding]; other site
224914002469	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224914002470	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224914002471	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
224914002472	E3 interaction surface; other site
224914002473	lipoyl attachment site [posttranslational modification]; other site
224914002474	e3 binding domain; Region: E3_binding; pfam02817
224914002475	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
224914002476	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
224914002477	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002478	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002479	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
224914002480	lipoyl synthase; Provisional; Region: PRK05481
224914002481	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914002482	FeS/SAM binding site; other site
224914002483	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
224914002484	putative coenzyme Q binding site [chemical binding]; other site
224914002485	classical (c) SDRs; Region: SDR_c; cd05233
224914002486	NAD(P) binding site [chemical binding]; other site
224914002487	active site
224914002488	Competence-damaged protein; Region: CinA; cl00666
224914002489	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
224914002490	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
224914002491	substrate binding site; other site
224914002492	dimer interface; other site
224914002493	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
224914002494	homotrimer interaction site [polypeptide binding]; other site
224914002495	zinc binding site [ion binding]; other site
224914002496	CDP-binding sites; other site
224914002497	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
224914002498	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
224914002499	FMN binding site [chemical binding]; other site
224914002500	active site
224914002501	catalytic residues [active]
224914002502	substrate binding site [chemical binding]; other site
224914002503	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
224914002504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914002505	dimer interface [polypeptide binding]; other site
224914002506	phosphorylation site [posttranslational modification]
224914002507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914002508	ATP binding site [chemical binding]; other site
224914002509	Mg2+ binding site [ion binding]; other site
224914002510	G-X-G motif; other site
224914002511	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
224914002512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914002513	active site
224914002514	phosphorylation site [posttranslational modification]
224914002515	intermolecular recognition site; other site
224914002516	dimerization interface [polypeptide binding]; other site
224914002517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914002518	Walker A motif; other site
224914002519	ATP binding site [chemical binding]; other site
224914002520	Walker B motif; other site
224914002521	arginine finger; other site
224914002522	Helix-turn-helix domains; Region: HTH; cl00088
224914002523	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
224914002524	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224914002525	dimerization interface [polypeptide binding]; other site
224914002526	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
224914002527	putative active site [active]
224914002528	heme pocket [chemical binding]; other site
224914002529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914002530	dimer interface [polypeptide binding]; other site
224914002531	phosphorylation site [posttranslational modification]
224914002532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914002533	ATP binding site [chemical binding]; other site
224914002534	Mg2+ binding site [ion binding]; other site
224914002535	G-X-G motif; other site
224914002536	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
224914002537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914002538	active site
224914002539	phosphorylation site [posttranslational modification]
224914002540	intermolecular recognition site; other site
224914002541	dimerization interface [polypeptide binding]; other site
224914002542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914002543	Walker A motif; other site
224914002544	ATP binding site [chemical binding]; other site
224914002545	Walker B motif; other site
224914002546	arginine finger; other site
224914002547	Helix-turn-helix domains; Region: HTH; cl00088
224914002548	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
224914002549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002550	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
224914002551	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002552	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
224914002553	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
224914002554	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
224914002555	Sm1 motif; other site
224914002556	intra - hexamer interaction site; other site
224914002557	inter - hexamer interaction site [polypeptide binding]; other site
224914002558	nucleotide binding pocket [chemical binding]; other site
224914002559	Sm2 motif; other site
224914002560	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
224914002561	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
224914002562	G1 box; other site
224914002563	GTP/Mg2+ binding site [chemical binding]; other site
224914002564	Switch I region; other site
224914002565	G2 box; other site
224914002566	G3 box; other site
224914002567	Switch II region; other site
224914002568	G4 box; other site
224914002569	G5 box; other site
224914002570	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
224914002571	oligomer interface [polypeptide binding]; other site
224914002572	active site residues [active]
224914002573	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
224914002574	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
224914002575	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914002576	Walker A motif; other site
224914002577	ATP binding site [chemical binding]; other site
224914002578	Walker B motif; other site
224914002579	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
224914002580	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
224914002581	Found in ATP-dependent protease La (LON); Region: LON; smart00464
224914002582	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914002583	Walker A motif; other site
224914002584	ATP binding site [chemical binding]; other site
224914002585	Walker B motif; other site
224914002586	arginine finger; other site
224914002587	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
224914002588	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
224914002589	IHF dimer interface [polypeptide binding]; other site
224914002590	IHF - DNA interface [nucleotide binding]; other site
224914002591	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
224914002592	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
224914002593	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
224914002594	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
224914002595	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
224914002596	dimer interface [polypeptide binding]; other site
224914002597	ssDNA binding site [nucleotide binding]; other site
224914002598	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224914002599	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
224914002600	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914002601	DNA-binding site [nucleotide binding]; DNA binding site
224914002602	UTRA domain; Region: UTRA; cl01230
224914002603	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914002604	active site
224914002605	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
224914002606	MarC family integral membrane protein; Region: MarC; cl00919
224914002607	DNA gyrase subunit A; Validated; Region: PRK05560
224914002608	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
224914002609	CAP-like domain; other site
224914002610	active site
224914002611	primary dimer interface [polypeptide binding]; other site
224914002612	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224914002613	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224914002614	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224914002615	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224914002616	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224914002617	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
224914002618	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
224914002619	active site
224914002620	(T/H)XGH motif; other site
224914002621	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
224914002622	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
224914002623	active site
224914002624	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
224914002625	active site
224914002626	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
224914002627	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
224914002628	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
224914002629	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
224914002630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224914002631	Helix-turn-helix domains; Region: HTH; cl00088
224914002632	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224914002633	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914002634	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914002635	multidrug efflux protein; Reviewed; Region: PRK09579
224914002636	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
224914002637	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
224914002638	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914002639	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914002640	Helix-turn-helix domains; Region: HTH; cl00088
224914002641	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914002642	dimerization interface [polypeptide binding]; other site
224914002643	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
224914002644	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224914002645	FAD binding site [chemical binding]; other site
224914002646	substrate binding pocket [chemical binding]; other site
224914002647	catalytic base [active]
224914002648	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
224914002649	CoA-transferase family III; Region: CoA_transf_3; pfam02515
224914002650	BRO family, N-terminal domain; Region: Bro-N; cl10591
224914002651	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
224914002652	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
224914002653	catalytic residues [active]
224914002654	catalytic nucleophile [active]
224914002655	Presynaptic Site I dimer interface [polypeptide binding]; other site
224914002656	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
224914002657	Synaptic Flat tetramer interface [polypeptide binding]; other site
224914002658	Synaptic Site I dimer interface [polypeptide binding]; other site
224914002659	DNA binding site [nucleotide binding]
224914002660	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
224914002661	DNA-binding interface [nucleotide binding]; DNA binding site
224914002662	Helix-turn-helix domains; Region: HTH; cl00088
224914002663	hypothetical protein; Provisional; Region: PRK10279
224914002664	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
224914002665	nucleophile elbow; other site
224914002666	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
224914002667	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
224914002668	homodecamer interface [polypeptide binding]; other site
224914002669	GTP cyclohydrolase I; Provisional; Region: PLN03044
224914002670	active site
224914002671	putative catalytic site residues [active]
224914002672	zinc binding site [ion binding]; other site
224914002673	GTP-CH-I/GFRP interaction surface; other site
224914002674	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
224914002675	trimerization site [polypeptide binding]; other site
224914002676	active site
224914002677	Haemolytic domain; Region: Haemolytic; cl00506
224914002678	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
224914002679	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
224914002680	Sporulation related domain; Region: SPOR; cl10051
224914002681	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
224914002682	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
224914002683	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
224914002684	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
224914002685	active site
224914002686	dimer interface [polypeptide binding]; other site
224914002687	motif 1; other site
224914002688	motif 2; other site
224914002689	motif 3; other site
224914002690	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
224914002691	anticodon binding site; other site
224914002692	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
224914002693	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
224914002694	dimer interface [polypeptide binding]; other site
224914002695	Flavin Reductases; Region: FlaRed; cl00801
224914002696	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
224914002697	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
224914002698	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
224914002699	UDP-glucose 4-epimerase; Region: PLN02240
224914002700	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
224914002701	NAD binding site [chemical binding]; other site
224914002702	homodimer interface [polypeptide binding]; other site
224914002703	active site
224914002704	substrate binding site [chemical binding]; other site
224914002705	Membrane transport protein; Region: Mem_trans; cl09117
224914002706	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
224914002707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
224914002708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914002709	S-adenosylmethionine binding site [chemical binding]; other site
224914002710	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
224914002711	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
224914002712	active site
224914002713	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
224914002714	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
224914002715	putative NAD(P) binding site [chemical binding]; other site
224914002716	putative substrate binding site [chemical binding]; other site
224914002717	catalytic Zn binding site [ion binding]; other site
224914002718	structural Zn binding site [ion binding]; other site
224914002719	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
224914002720	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914002721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914002722	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
224914002723	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914002724	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
224914002725	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914002726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914002727	metal binding site [ion binding]; metal-binding site
224914002728	active site
224914002729	I-site; other site
224914002730	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224914002731	Coenzyme A binding pocket [chemical binding]; other site
224914002732	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
224914002733	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
224914002734	active site residue [active]
224914002735	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
224914002736	active site residue [active]
224914002737	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
224914002738	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
224914002739	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
224914002740	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
224914002741	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
224914002742	dimer interface [polypeptide binding]; other site
224914002743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914002744	catalytic residue [active]
224914002745	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
224914002746	DEAD-like helicases superfamily; Region: DEXDc; smart00487
224914002747	ATP binding site [chemical binding]; other site
224914002748	Mg++ binding site [ion binding]; other site
224914002749	motif III; other site
224914002750	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914002751	nucleotide binding region [chemical binding]; other site
224914002752	ATP-binding site [chemical binding]; other site
224914002753	threonine dehydratase; Validated; Region: PRK08639
224914002754	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
224914002755	tetramer interface [polypeptide binding]; other site
224914002756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914002757	catalytic residue [active]
224914002758	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
224914002759	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
224914002760	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
224914002761	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
224914002762	putative MPT binding site; other site
224914002763	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
224914002764	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224914002765	Ligand Binding Site [chemical binding]; other site
224914002766	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
224914002767	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
224914002768	nudix motif; other site
224914002769	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
224914002770	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
224914002771	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
224914002772	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
224914002773	active site
224914002774	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
224914002775	TSCPD domain; Region: TSCPD; cl14834
224914002776	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
224914002777	Mechanosensitive ion channel; Region: MS_channel; pfam00924
224914002778	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
224914002779	Predicted flavoproteins [General function prediction only]; Region: COG2081
224914002780	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002782	PAS domain; Region: PAS_9; pfam13426
224914002783	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
224914002784	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914002785	dimer interface [polypeptide binding]; other site
224914002786	phosphorylation site [posttranslational modification]
224914002787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914002788	ATP binding site [chemical binding]; other site
224914002789	Mg2+ binding site [ion binding]; other site
224914002790	G-X-G motif; other site
224914002791	Response regulator receiver domain; Region: Response_reg; pfam00072
224914002792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914002793	active site
224914002794	phosphorylation site [posttranslational modification]
224914002795	intermolecular recognition site; other site
224914002796	dimerization interface [polypeptide binding]; other site
224914002797	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
224914002798	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224914002799	catalytic core [active]
224914002800	YcjX-like family, DUF463; Region: DUF463; cl01193
224914002801	Predicted membrane protein [Function unknown]; Region: COG3768
224914002802	Domain of unknown function (DUF697); Region: DUF697; cl12064
224914002803	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
224914002804	catalytic center binding site [active]
224914002805	ATP binding site [chemical binding]; other site
224914002806	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
224914002807	homooctamer interface [polypeptide binding]; other site
224914002808	active site
224914002809	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
224914002810	dihydropteroate synthase; Region: DHPS; TIGR01496
224914002811	substrate binding pocket [chemical binding]; other site
224914002812	dimer interface [polypeptide binding]; other site
224914002813	inhibitor binding site; inhibition site
224914002814	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
224914002815	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
224914002816	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224914002817	catalytic loop [active]
224914002818	iron binding site [ion binding]; other site
224914002819	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
224914002820	Protein of unknown function (DUF330); Region: DUF330; cl01135
224914002821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
224914002822	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
224914002823	mce related protein; Region: MCE; cl15431
224914002824	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
224914002825	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
224914002826	Walker A/P-loop; other site
224914002827	ATP binding site [chemical binding]; other site
224914002828	Q-loop/lid; other site
224914002829	ABC transporter signature motif; other site
224914002830	Walker B; other site
224914002831	D-loop; other site
224914002832	H-loop/switch region; other site
224914002833	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
224914002834	Domain of unknown function DUF140; Region: DUF140; cl00510
224914002835	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
224914002836	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
224914002837	active site
224914002838	malic enzyme; Reviewed; Region: PRK12862
224914002839	Malic enzyme, N-terminal domain; Region: malic; pfam00390
224914002840	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
224914002841	putative NAD(P) binding site [chemical binding]; other site
224914002842	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
224914002843	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
224914002844	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224914002845	active site
224914002846	HIGH motif; other site
224914002847	nucleotide binding site [chemical binding]; other site
224914002848	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
224914002849	active site
224914002850	KMSKS motif; other site
224914002851	NAD synthetase; Provisional; Region: PRK13981
224914002852	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
224914002853	multimer interface [polypeptide binding]; other site
224914002854	active site
224914002855	catalytic triad [active]
224914002856	protein interface 1 [polypeptide binding]; other site
224914002857	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
224914002858	homodimer interface [polypeptide binding]; other site
224914002859	NAD binding pocket [chemical binding]; other site
224914002860	ATP binding pocket [chemical binding]; other site
224914002861	Mg binding site [ion binding]; other site
224914002862	active-site loop [active]
224914002863	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
224914002864	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
224914002865	glutathione reductase; Validated; Region: PRK06116
224914002866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002867	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
224914002868	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
224914002869	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
224914002870	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224914002871	active site
224914002872	dimer interface [polypeptide binding]; other site
224914002873	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
224914002874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914002875	motif II; other site
224914002876	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
224914002877	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
224914002878	putative substrate binding site [chemical binding]; other site
224914002879	putative ATP binding site [chemical binding]; other site
224914002880	Nitrogen regulatory protein P-II; Region: P-II; cl00412
224914002881	glutamine synthetase; Provisional; Region: glnA; PRK09469
224914002882	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
224914002883	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
224914002884	ATP12 chaperone protein; Region: ATP12; cl02228
224914002885	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
224914002886	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914002887	motif I; other site
224914002888	active site
224914002889	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914002890	motif II; other site
224914002891	EamA-like transporter family; Region: EamA; cl01037
224914002892	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
224914002893	EamA-like transporter family; Region: EamA; cl01037
224914002894	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
224914002895	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
224914002896	active site
224914002897	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
224914002898	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914002899	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
224914002900	Walker A/P-loop; other site
224914002901	ATP binding site [chemical binding]; other site
224914002902	Q-loop/lid; other site
224914002903	ABC transporter signature motif; other site
224914002904	Walker B; other site
224914002905	D-loop; other site
224914002906	H-loop/switch region; other site
224914002907	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
224914002908	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
224914002909	active site
224914002910	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
224914002911	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
224914002912	active site
224914002913	HIGH motif; other site
224914002914	KMSKS motif; other site
224914002915	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
224914002916	tRNA binding surface [nucleotide binding]; other site
224914002917	anticodon binding site; other site
224914002918	DNA polymerase III subunit delta'; Validated; Region: PRK09112
224914002919	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914002920	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914002921	thymidylate kinase; Validated; Region: tmk; PRK00698
224914002922	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
224914002923	TMP-binding site; other site
224914002924	ATP-binding site [chemical binding]; other site
224914002925	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
224914002926	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
224914002927	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
224914002928	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
224914002929	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
224914002930	ArsC family; Region: ArsC; pfam03960
224914002931	catalytic residues [active]
224914002932	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
224914002933	Predicted lysozyme (DUF847); Region: DUF847; pfam05838
224914002934	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
224914002935	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224914002936	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224914002937	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224914002938	Transposase domain (DUF772); Region: DUF772; cl15789
224914002939	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914002940	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
224914002941	Protein of unknown function (DUF497); Region: DUF497; cl01108
224914002942	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
224914002943	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
224914002944	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
224914002945	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
224914002946	Int/Topo IB signature motif; other site
224914002947	active site
224914002948	catalytic residues [active]
224914002949	DNA binding site [nucleotide binding]
224914002950	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
224914002951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
224914002952	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
224914002953	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914002954	fumarate hydratase; Provisional; Region: PRK15389
224914002955	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
224914002956	Fumarase C-terminus; Region: Fumerase_C; cl00795
224914002957	hypothetical protein; Provisional; Region: PRK06753
224914002958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002959	Protein of unknown function (DUF971); Region: DUF971; cl01414
224914002960	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
224914002961	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914002962	FeS/SAM binding site; other site
224914002963	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
224914002964	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
224914002965	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
224914002966	GTP binding site; other site
224914002967	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914002968	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224914002969	substrate binding pocket [chemical binding]; other site
224914002970	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
224914002971	putative substrate binding pocket (H-site) [chemical binding]; other site
224914002972	putative N-terminal domain interface [polypeptide binding]; other site
224914002973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914002974	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
224914002975	NAD(P) binding pocket [chemical binding]; other site
224914002976	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
224914002977	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
224914002978	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
224914002979	HIGH motif; other site
224914002980	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
224914002981	active site
224914002982	KMSKS motif; other site
224914002983	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
224914002984	tRNA binding surface [nucleotide binding]; other site
224914002985	anticodon binding site; other site
224914002986	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
224914002987	Protein of unknown function (DUF2497); Region: DUF2497; cl11534
224914002988	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
224914002989	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
224914002990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914002991	S-adenosylmethionine binding site [chemical binding]; other site
224914002992	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
224914002993	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
224914002994	helicase 45; Provisional; Region: PTZ00424
224914002995	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
224914002996	ATP binding site [chemical binding]; other site
224914002997	Mg++ binding site [ion binding]; other site
224914002998	motif III; other site
224914002999	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914003000	nucleotide binding region [chemical binding]; other site
224914003001	ATP-binding site [chemical binding]; other site
224914003002	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
224914003003	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
224914003004	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224914003005	active site
224914003006	Domain of unknown function DUF59; Region: DUF59; cl00941
224914003007	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
224914003008	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
224914003009	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914003010	catalytic residue [active]
224914003011	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
224914003012	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
224914003013	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
224914003014	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
224914003015	Walker A/P-loop; other site
224914003016	ATP binding site [chemical binding]; other site
224914003017	Q-loop/lid; other site
224914003018	ABC transporter signature motif; other site
224914003019	Walker B; other site
224914003020	D-loop; other site
224914003021	H-loop/switch region; other site
224914003022	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
224914003023	putative ABC transporter; Region: ycf24; CHL00085
224914003024	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914003025	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
224914003026	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914003027	catalytic residue [active]
224914003028	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
224914003029	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
224914003030	Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217
224914003031	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
224914003032	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
224914003033	active site
224914003034	HIGH motif; other site
224914003035	dimer interface [polypeptide binding]; other site
224914003036	KMSKS motif; other site
224914003037	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224914003038	RNA binding surface [nucleotide binding]; other site
224914003039	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
224914003040	catalytic triad [active]
224914003041	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
224914003042	dinuclear metal binding motif [ion binding]; other site
224914003043	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003044	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003045	peptide chain release factor 2; Provisional; Region: PRK07342
224914003046	RF-1 domain; Region: RF-1; cl02875
224914003047	RF-1 domain; Region: RF-1; cl02875
224914003048	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
224914003049	Transglycosylase; Region: Transgly; cl07896
224914003050	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
224914003051	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
224914003052	active site
224914003053	metal binding site [ion binding]; metal-binding site
224914003054	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
224914003055	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224914003056	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
224914003057	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224914003058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914003059	homodimer interface [polypeptide binding]; other site
224914003060	catalytic residue [active]
224914003061	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
224914003062	Peptidase family M48; Region: Peptidase_M48; cl12018
224914003063	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
224914003064	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
224914003065	catalytic residues [active]
224914003066	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
224914003067	trimer interface [polypeptide binding]; other site
224914003068	active site
224914003069	dimer interface [polypeptide binding]; other site
224914003070	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
224914003071	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224914003072	carboxyltransferase (CT) interaction site; other site
224914003073	biotinylation site [posttranslational modification]; other site
224914003074	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
224914003075	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224914003076	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914003077	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
224914003078	Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006
224914003079	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
224914003080	NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534
224914003081	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
224914003082	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914003083	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
224914003084	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
224914003085	GatB domain; Region: GatB_Yqey; cl11497
224914003086	trigger factor; Provisional; Region: tig; PRK01490
224914003087	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
224914003088	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
224914003089	Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929
224914003090	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
224914003091	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
224914003092	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
224914003093	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440
224914003094	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
224914003095	substrate binding pocket [chemical binding]; other site
224914003096	substrate-Mg2+ binding site; other site
224914003097	aspartate-rich region 1; other site
224914003098	aspartate-rich region 2; other site
224914003099	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
224914003100	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023
224914003101	Protein export membrane protein; Region: SecD_SecF; cl14618
224914003102	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
224914003103	Protein export membrane protein; Region: SecD_SecF; cl14618
224914003104	Preprotein translocase subunit; Region: YajC; cl00806
224914003105	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
224914003106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914003107	Walker A motif; other site
224914003108	ATP binding site [chemical binding]; other site
224914003109	Walker B motif; other site
224914003110	autolysin; Reviewed; Region: PRK06347
224914003111	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
224914003112	putative peptidoglycan binding site; other site
224914003113	Peptidase family M23; Region: Peptidase_M23; pfam01551
224914003114	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
224914003115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914003116	S-adenosylmethionine binding site [chemical binding]; other site
224914003117	Survival protein SurE; Region: SurE; cl00448
224914003118	seryl-tRNA synthetase; Provisional; Region: PRK05431
224914003119	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
224914003120	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
224914003121	dimer interface [polypeptide binding]; other site
224914003122	active site
224914003123	motif 1; other site
224914003124	motif 2; other site
224914003125	motif 3; other site
224914003126	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
224914003127	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
224914003128	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
224914003129	ScpA/B protein; Region: ScpA_ScpB; cl00598
224914003130	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
224914003131	Sporulation related domain; Region: SPOR; cl10051
224914003132	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
224914003133	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
224914003134	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
224914003135	active site
224914003136	HIGH motif; other site
224914003137	KMSK motif region; other site
224914003138	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
224914003139	tRNA binding surface [nucleotide binding]; other site
224914003140	anticodon binding site; other site
224914003141	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
224914003142	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
224914003143	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
224914003144	putative metal binding site [ion binding]; other site
224914003145	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
224914003146	putative phosphate binding site [ion binding]; other site
224914003147	putative catalytic site [active]
224914003148	active site
224914003149	metal binding site A [ion binding]; metal-binding site
224914003150	DNA binding site [nucleotide binding]
224914003151	putative AP binding site [nucleotide binding]; other site
224914003152	putative metal binding site B [ion binding]; other site
224914003153	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
224914003154	Sel1 repeat; Region: Sel1; cl02723
224914003155	Staphylococcal nuclease homologues; Region: SNc; smart00318
224914003156	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
224914003157	Catalytic site; other site
224914003158	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
224914003159	putative uracil binding site [chemical binding]; other site
224914003160	putative active site [active]
224914003161	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224914003162	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914003163	putative DNA binding site [nucleotide binding]; other site
224914003164	putative Zn2+ binding site [ion binding]; other site
224914003165	Helix-turn-helix domains; Region: HTH; cl00088
224914003166	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
224914003167	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
224914003168	putative dimer interface [polypeptide binding]; other site
224914003169	active site pocket [active]
224914003170	putative cataytic base [active]
224914003171	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
224914003172	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
224914003173	Predicted aspartyl protease [General function prediction only]; Region: COG3577
224914003174	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
224914003175	catalytic motif [active]
224914003176	Catalytic residue [active]
224914003177	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
224914003178	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
224914003179	FMN binding site [chemical binding]; other site
224914003180	active site
224914003181	catalytic residues [active]
224914003182	substrate binding site [chemical binding]; other site
224914003183	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
224914003184	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224914003185	substrate binding pocket [chemical binding]; other site
224914003186	membrane-bound complex binding site; other site
224914003187	hinge residues; other site
224914003188	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
224914003189	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914003190	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
224914003191	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224914003192	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
224914003193	active site
224914003194	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
224914003195	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224914003196	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
224914003197	substrate binding site [chemical binding]; other site
224914003198	ATP binding site [chemical binding]; other site
224914003199	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
224914003200	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
224914003201	active site
224914003202	catalytic residues [active]
224914003203	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
224914003204	Predicted lysozyme (DUF847); Region: DUF847; pfam05838
224914003205	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
224914003206	Phosphopantetheine attachment site; Region: PP-binding; cl09936
224914003207	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
224914003208	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
224914003209	active site
224914003210	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
224914003211	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
224914003212	dimer interface [polypeptide binding]; other site
224914003213	active site
224914003214	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
224914003215	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
224914003216	putative NAD(P) binding site [chemical binding]; other site
224914003217	structural Zn binding site [ion binding]; other site
224914003218	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
224914003219	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
224914003220	putative acyl-acceptor binding pocket; other site
224914003221	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
224914003222	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
224914003223	substrate binding site [chemical binding]; other site
224914003224	hexamer interface [polypeptide binding]; other site
224914003225	metal binding site [ion binding]; metal-binding site
224914003226	adenylosuccinate lyase; Provisional; Region: PRK07492
224914003227	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
224914003228	tetramer interface [polypeptide binding]; other site
224914003229	active site
224914003230	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
224914003231	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
224914003232	putative metal binding site [ion binding]; other site
224914003233	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
224914003234	active site
224914003235	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914003236	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
224914003237	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
224914003238	Domain of unknown function (DUF1476); Region: DUF1476; cl11571
224914003239	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
224914003240	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
224914003241	ATP binding site [chemical binding]; other site
224914003242	active site
224914003243	substrate binding site [chemical binding]; other site
224914003244	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
224914003245	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
224914003246	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
224914003247	putative active site [active]
224914003248	catalytic triad [active]
224914003249	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
224914003250	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
224914003251	C-terminal domain interface [polypeptide binding]; other site
224914003252	GSH binding site (G-site) [chemical binding]; other site
224914003253	dimer interface [polypeptide binding]; other site
224914003254	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
224914003255	N-terminal domain interface [polypeptide binding]; other site
224914003256	dimer interface [polypeptide binding]; other site
224914003257	substrate binding pocket (H-site) [chemical binding]; other site
224914003258	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
224914003259	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
224914003260	dimerization interface [polypeptide binding]; other site
224914003261	ATP binding site [chemical binding]; other site
224914003262	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
224914003263	dimerization interface [polypeptide binding]; other site
224914003264	ATP binding site [chemical binding]; other site
224914003265	BolA-like protein; Region: BolA; cl00386
224914003266	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
224914003267	putative GSH binding site [chemical binding]; other site
224914003268	catalytic residues [active]
224914003269	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
224914003270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914003271	putative substrate translocation pore; other site
224914003272	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
224914003273	active site
224914003274	putative lithium-binding site [ion binding]; other site
224914003275	substrate binding site [chemical binding]; other site
224914003276	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
224914003277	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
224914003278	Ligand Binding Site [chemical binding]; other site
224914003279	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
224914003280	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
224914003281	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224914003282	RNA binding surface [nucleotide binding]; other site
224914003283	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
224914003284	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
224914003285	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
224914003286	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
224914003287	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
224914003288	Protein of unknown function, DUF655; Region: DUF655; pfam04919
224914003289	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
224914003290	generic binding surface II; other site
224914003291	generic binding surface I; other site
224914003292	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224914003293	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
224914003294	Walker A/P-loop; other site
224914003295	ATP binding site [chemical binding]; other site
224914003296	Q-loop/lid; other site
224914003297	ABC transporter signature motif; other site
224914003298	Walker B; other site
224914003299	D-loop; other site
224914003300	H-loop/switch region; other site
224914003301	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
224914003302	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224914003303	FtsX-like permease family; Region: FtsX; pfam02687
224914003304	prolyl-tRNA synthetase; Provisional; Region: PRK12325
224914003305	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
224914003306	dimer interface [polypeptide binding]; other site
224914003307	motif 1; other site
224914003308	active site
224914003309	motif 2; other site
224914003310	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
224914003311	active site
224914003312	motif 3; other site
224914003313	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
224914003314	anticodon binding site; other site
224914003315	Protein of unknown function (DUF1467); Region: DUF1467; cl11569
224914003316	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914003317	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
224914003318	dimer interface [polypeptide binding]; other site
224914003319	substrate binding site [chemical binding]; other site
224914003320	metal binding site [ion binding]; metal-binding site
224914003321	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
224914003322	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
224914003323	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
224914003324	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
224914003325	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
224914003326	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
224914003327	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
224914003328	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
224914003329	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
224914003330	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
224914003331	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
224914003332	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
224914003333	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
224914003334	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
224914003335	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
224914003336	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
224914003337	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
224914003338	4Fe-4S binding domain; Region: Fer4; cl02805
224914003339	4Fe-4S binding domain; Region: Fer4; cl02805
224914003340	NADH dehydrogenase; Region: NADHdh; cl00469
224914003341	NADH dehydrogenase subunit G; Validated; Region: PRK09130
224914003342	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224914003343	catalytic loop [active]
224914003344	iron binding site [ion binding]; other site
224914003345	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
224914003346	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
224914003347	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
224914003348	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
224914003349	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
224914003350	SLBB domain; Region: SLBB; pfam10531
224914003351	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
224914003352	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
224914003353	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
224914003354	putative dimer interface [polypeptide binding]; other site
224914003355	[2Fe-2S] cluster binding site [ion binding]; other site
224914003356	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
224914003357	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
224914003358	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365
224914003359	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
224914003360	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
224914003361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003362	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003363	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
224914003364	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
224914003365	homodimer interface [polypeptide binding]; other site
224914003366	substrate-cofactor binding pocket; other site
224914003367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914003368	catalytic residue [active]
224914003369	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
224914003370	CoenzymeA binding site [chemical binding]; other site
224914003371	subunit interaction site [polypeptide binding]; other site
224914003372	PHB binding site; other site
224914003373	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
224914003374	23S rRNA interface [nucleotide binding]; other site
224914003375	L3 interface [polypeptide binding]; other site
224914003376	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
224914003377	Arginase family; Region: Arginase; cl00306
224914003378	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
224914003379	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914003380	cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127
224914003381	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
224914003382	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
224914003383	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
224914003384	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
224914003385	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
224914003386	SLBB domain; Region: SLBB; pfam10531
224914003387	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
224914003388	Bacterial sugar transferase; Region: Bac_transf; cl00939
224914003389	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
224914003390	DNA binding residues [nucleotide binding]
224914003391	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
224914003392	IHF dimer interface [polypeptide binding]; other site
224914003393	IHF - DNA interface [nucleotide binding]; other site
224914003394	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
224914003395	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
224914003396	dimer interface [polypeptide binding]; other site
224914003397	active site
224914003398	CoA binding pocket [chemical binding]; other site
224914003399	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
224914003400	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
224914003401	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
224914003402	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
224914003403	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
224914003404	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
224914003405	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
224914003406	putative RNA binding site [nucleotide binding]; other site
224914003407	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
224914003408	homopentamer interface [polypeptide binding]; other site
224914003409	active site
224914003410	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
224914003411	Lumazine binding domain; Region: Lum_binding; pfam00677
224914003412	Lumazine binding domain; Region: Lum_binding; pfam00677
224914003413	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
224914003414	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
224914003415	catalytic motif [active]
224914003416	Zn binding site [ion binding]; other site
224914003417	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
224914003418	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
224914003419	ATP cone domain; Region: ATP-cone; pfam03477
224914003420	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
224914003421	active site
224914003422	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914003423	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914003424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
224914003425	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
224914003426	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914003427	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914003428	Transcriptional regulators [Transcription]; Region: MarR; COG1846
224914003429	Helix-turn-helix domains; Region: HTH; cl00088
224914003430	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
224914003431	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914003432	substrate binding site [chemical binding]; other site
224914003433	oxyanion hole (OAH) forming residues; other site
224914003434	trimer interface [polypeptide binding]; other site
224914003435	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
224914003436	dimer interface [polypeptide binding]; other site
224914003437	allosteric magnesium binding site [ion binding]; other site
224914003438	active site
224914003439	aspartate-rich active site metal binding site; other site
224914003440	Schiff base residues; other site
224914003441	RDD family; Region: RDD; cl00746
224914003442	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
224914003443	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
224914003444	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914003445	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
224914003446	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
224914003447	CAP-like domain; other site
224914003448	active site
224914003449	primary dimer interface [polypeptide binding]; other site
224914003450	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224914003451	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
224914003452	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
224914003453	dimer interface [polypeptide binding]; other site
224914003454	anticodon binding site; other site
224914003455	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
224914003456	homodimer interface [polypeptide binding]; other site
224914003457	motif 1; other site
224914003458	active site
224914003459	motif 2; other site
224914003460	GAD domain; Region: GAD; pfam02938
224914003461	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
224914003462	active site
224914003463	motif 3; other site
224914003464	ribonuclease D; Region: rnd; TIGR01388
224914003465	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
224914003466	putative active site [active]
224914003467	catalytic site [active]
224914003468	putative substrate binding site [chemical binding]; other site
224914003469	HRDC domain; Region: HRDC; cl02578
224914003470	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
224914003471	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
224914003472	polyphosphate kinase; Provisional; Region: PRK05443
224914003473	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
224914003474	putative domain interface [polypeptide binding]; other site
224914003475	putative active site [active]
224914003476	catalytic site [active]
224914003477	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
224914003478	putative domain interface [polypeptide binding]; other site
224914003479	putative active site [active]
224914003480	catalytic site [active]
224914003481	Zinc-finger domain; Region: zf-CHCC; cl01821
224914003482	salicylate hydroxylase; Provisional; Region: PRK06475
224914003483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914003484	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224914003485	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
224914003486	Walker A/P-loop; other site
224914003487	ATP binding site [chemical binding]; other site
224914003488	Q-loop/lid; other site
224914003489	ABC transporter signature motif; other site
224914003490	Walker B; other site
224914003491	D-loop; other site
224914003492	H-loop/switch region; other site
224914003493	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
224914003494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914003495	dimer interface [polypeptide binding]; other site
224914003496	conserved gate region; other site
224914003497	putative PBP binding loops; other site
224914003498	ABC-ATPase subunit interface; other site
224914003499	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
224914003500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914003501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914003502	putative PBP binding loops; other site
224914003503	dimer interface [polypeptide binding]; other site
224914003504	ABC-ATPase subunit interface; other site
224914003505	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
224914003506	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224914003507	substrate binding pocket [chemical binding]; other site
224914003508	membrane-bound complex binding site; other site
224914003509	hinge residues; other site
224914003510	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
224914003511	active site
224914003512	cystathionine beta-lyase; Provisional; Region: PRK05967
224914003513	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
224914003514	homodimer interface [polypeptide binding]; other site
224914003515	substrate-cofactor binding pocket; other site
224914003516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914003517	catalytic residue [active]
224914003518	Bacterial SH3 domain; Region: SH3_3; cl02551
224914003519	TIR domain; Region: TIR; cl02060
224914003520	Domain of unknown function (DUF955); Region: DUF955; cl01076
224914003521	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914003522	Integrase core domain; Region: rve; cl01316
224914003523	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
224914003524	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370
224914003525	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224914003526	non-specific DNA binding site [nucleotide binding]; other site
224914003527	salt bridge; other site
224914003528	sequence-specific DNA binding site [nucleotide binding]; other site
224914003529	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
224914003530	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914003531	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
224914003532	active site
224914003533	substrate binding site [chemical binding]; other site
224914003534	catalytic site [active]
224914003535	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
224914003536	L-lactate permease; Region: Lactate_perm; cl00701
224914003537	L-lactate permease; Region: Lactate_perm; cl00701
224914003538	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
224914003539	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
224914003540	putative NAD(P) binding site [chemical binding]; other site
224914003541	putative active site [active]
224914003542	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914003543	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
224914003544	NAD(P) binding site [chemical binding]; other site
224914003545	active site
224914003546	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914003547	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
224914003548	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
224914003549	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
224914003550	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
224914003551	dimerization interface [polypeptide binding]; other site
224914003552	putative ATP binding site [chemical binding]; other site
224914003553	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
224914003554	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
224914003555	active site
224914003556	substrate binding site [chemical binding]; other site
224914003557	cosubstrate binding site; other site
224914003558	catalytic site [active]
224914003559	Protein of unknown function (DUF992); Region: DUF992; pfam06186
224914003560	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
224914003561	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
224914003562	putative [4Fe-4S] binding site [ion binding]; other site
224914003563	putative molybdopterin cofactor binding site [chemical binding]; other site
224914003564	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
224914003565	putative molybdopterin cofactor binding site; other site
224914003566	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
224914003567	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
224914003568	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
224914003569	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
224914003570	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914003571	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
224914003572	B1 nucleotide binding pocket [chemical binding]; other site
224914003573	B2 nucleotide binding pocket [chemical binding]; other site
224914003574	CAS motifs; other site
224914003575	active site
224914003576	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
224914003577	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
224914003578	putative C-terminal domain interface [polypeptide binding]; other site
224914003579	putative GSH binding site (G-site) [chemical binding]; other site
224914003580	putative dimer interface [polypeptide binding]; other site
224914003581	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
224914003582	dimer interface [polypeptide binding]; other site
224914003583	N-terminal domain interface [polypeptide binding]; other site
224914003584	putative substrate binding pocket (H-site) [chemical binding]; other site
224914003585	Surface antigen; Region: Surface_Ag_2; cl01155
224914003586	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
224914003587	pteridine reductase; Provisional; Region: PRK09135
224914003588	NADP binding site [chemical binding]; other site
224914003589	substrate binding pocket [chemical binding]; other site
224914003590	active site
224914003591	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
224914003592	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
224914003593	GIY-YIG motif/motif A; other site
224914003594	active site
224914003595	catalytic site [active]
224914003596	putative DNA binding site [nucleotide binding]; other site
224914003597	metal binding site [ion binding]; metal-binding site
224914003598	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
224914003599	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
224914003600	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
224914003601	MoaE interaction surface [polypeptide binding]; other site
224914003602	MoeB interaction surface [polypeptide binding]; other site
224914003603	thiocarboxylated glycine; other site
224914003604	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
224914003605	MoaE homodimer interface [polypeptide binding]; other site
224914003606	MoaD interaction [polypeptide binding]; other site
224914003607	active site residues [active]
224914003608	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
224914003609	META domain; Region: META; cl01245
224914003610	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
224914003611	active site
224914003612	multimer interface [polypeptide binding]; other site
224914003613	DinB superfamily; Region: DinB_2; cl00986
224914003614	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
224914003615	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
224914003616	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914003617	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
224914003618	ABC transporter; Region: ABC_tran_2; pfam12848
224914003619	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
224914003620	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
224914003621	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
224914003622	multifunctional aminopeptidase A; Provisional; Region: PRK00913
224914003623	interface (dimer of trimers) [polypeptide binding]; other site
224914003624	Substrate-binding/catalytic site; other site
224914003625	Zn-binding sites [ion binding]; other site
224914003626	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
224914003627	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
224914003628	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
224914003629	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
224914003630	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
224914003631	OstA-like protein; Region: OstA; cl00844
224914003632	Organic solvent tolerance protein; Region: OstA_C; pfam04453
224914003633	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
224914003634	SurA N-terminal domain; Region: SurA_N_3; cl07813
224914003635	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
224914003636	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
224914003637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914003638	S-adenosylmethionine binding site [chemical binding]; other site
224914003639	Peptidase family M23; Region: Peptidase_M23; pfam01551
224914003640	Predicted permeases [General function prediction only]; Region: RarD; COG2962
224914003641	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
224914003642	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
224914003643	active site
224914003644	catalytic residues [active]
224914003645	metal binding site [ion binding]; metal-binding site
224914003646	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
224914003647	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
224914003648	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
224914003649	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224914003650	active site
224914003651	HIGH motif; other site
224914003652	nucleotide binding site [chemical binding]; other site
224914003653	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
224914003654	KMSKS motif; other site
224914003655	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
224914003656	LysE type translocator; Region: LysE; cl00565
224914003657	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
224914003658	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
224914003659	nudix motif; other site
224914003660	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
224914003661	dihydroorotase; Validated; Region: PRK09060
224914003662	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
224914003663	active site
224914003664	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
224914003665	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
224914003666	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
224914003667	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
224914003668	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
224914003669	Recombination protein O N terminal; Region: RecO_N; pfam11967
224914003670	DNA repair protein RecO; Region: reco; TIGR00613
224914003671	Recombination protein O C terminal; Region: RecO_C; pfam02565
224914003672	GTPase Era; Reviewed; Region: era; PRK00089
224914003673	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163
224914003674	G1 box; other site
224914003675	GTP/Mg2+ binding site [chemical binding]; other site
224914003676	Switch I region; other site
224914003677	G2 box; other site
224914003678	Switch II region; other site
224914003679	G3 box; other site
224914003680	G4 box; other site
224914003681	G5 box; other site
224914003682	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
224914003683	ribonuclease III; Reviewed; Region: PRK12371
224914003684	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
224914003685	dimerization interface [polypeptide binding]; other site
224914003686	active site
224914003687	metal binding site [ion binding]; metal-binding site
224914003688	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
224914003689	dsRNA binding site [nucleotide binding]; other site
224914003690	signal peptidase I; Provisional; Region: PRK10861
224914003691	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224914003692	Catalytic site [active]
224914003693	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224914003694	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
224914003695	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
224914003696	Cupin domain; Region: Cupin_2; cl09118
224914003697	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
224914003698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914003699	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224914003700	putative substrate translocation pore; other site
224914003701	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
224914003702	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914003703	FeS/SAM binding site; other site
224914003704	HemN C-terminal domain; Region: HemN_C; pfam06969
224914003705	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
224914003706	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224914003707	ligand binding site [chemical binding]; other site
224914003708	flexible hinge region; other site
224914003709	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
224914003710	putative switch regulator; other site
224914003711	non-specific DNA interactions [nucleotide binding]; other site
224914003712	DNA binding site [nucleotide binding]
224914003713	sequence specific DNA binding site [nucleotide binding]; other site
224914003714	putative cAMP binding site [chemical binding]; other site
224914003715	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
224914003716	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
224914003717	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
224914003718	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
224914003719	synthetase active site [active]
224914003720	NTP binding site [chemical binding]; other site
224914003721	metal binding site [ion binding]; metal-binding site
224914003722	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
224914003723	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
224914003724	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
224914003725	Uncharacterized conserved protein [Function unknown]; Region: COG1432
224914003726	LabA_like proteins; Region: LabA; cd10911
224914003727	putative metal binding site [ion binding]; other site
224914003728	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
224914003729	Fe-S cluster binding site [ion binding]; other site
224914003730	DNA binding site [nucleotide binding]
224914003731	active site
224914003732	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
224914003733	SmpB-tmRNA interface; other site
224914003734	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
224914003735	dihydrodipicolinate synthase; Region: dapA; TIGR00674
224914003736	dimer interface [polypeptide binding]; other site
224914003737	active site
224914003738	catalytic residue [active]
224914003739	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
224914003740	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
224914003741	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224914003742	catalytic residue [active]
224914003743	Uncharacterized conserved protein [Function unknown]; Region: COG3743
224914003744	Porin subfamily; Region: Porin_2; pfam02530
224914003745	Porin subfamily; Region: Porin_2; pfam02530
224914003746	Phage integrase family; Region: Phage_integrase; pfam00589
224914003747	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
224914003748	DNA binding site [nucleotide binding]
224914003749	Int/Topo IB signature motif; other site
224914003750	active site
224914003751	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224914003752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914003753	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914003754	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914003755	catalytic residue [active]
224914003756	Protein of unknown function (DUF423); Region: DUF423; cl01008
224914003757	Uncharacterized conserved protein [Function unknown]; Region: COG1284
224914003758	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224914003759	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
224914003760	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
224914003761	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
224914003762	C-terminal domain interface [polypeptide binding]; other site
224914003763	GSH binding site (G-site) [chemical binding]; other site
224914003764	dimer interface [polypeptide binding]; other site
224914003765	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
224914003766	N-terminal domain interface [polypeptide binding]; other site
224914003767	putative dimer interface [polypeptide binding]; other site
224914003768	active site
224914003769	AMP nucleosidase; Provisional; Region: PRK08292
224914003770	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
224914003771	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
224914003772	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
224914003773	putative catalytic site [active]
224914003774	putative metal binding site [ion binding]; other site
224914003775	putative phosphate binding site [ion binding]; other site
224914003776	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
224914003777	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914003778	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
224914003779	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
224914003780	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
224914003781	Fe-S cluster binding site [ion binding]; other site
224914003782	active site
224914003783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914003784	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224914003785	putative substrate translocation pore; other site
224914003786	EamA-like transporter family; Region: EamA; cl01037
224914003787	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
224914003788	aminopeptidase N; Provisional; Region: pepN; PRK14015
224914003789	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
224914003790	active site
224914003791	Zn binding site [ion binding]; other site
224914003792	PAS fold; Region: PAS_3; pfam08447
224914003793	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
224914003794	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
224914003795	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914003796	dimer interface [polypeptide binding]; other site
224914003797	phosphorylation site [posttranslational modification]
224914003798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914003799	ATP binding site [chemical binding]; other site
224914003800	Mg2+ binding site [ion binding]; other site
224914003801	G-X-G motif; other site
224914003802	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
224914003803	O-Antigen ligase; Region: Wzy_C; cl04850
224914003804	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
224914003805	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
224914003806	metal binding triad; other site
224914003807	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
224914003808	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
224914003809	metal binding triad; other site
224914003810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224914003811	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224914003812	dimerization interface [polypeptide binding]; other site
224914003813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914003814	dimer interface [polypeptide binding]; other site
224914003815	phosphorylation site [posttranslational modification]
224914003816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914003817	ATP binding site [chemical binding]; other site
224914003818	Mg2+ binding site [ion binding]; other site
224914003819	G-X-G motif; other site
224914003820	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
224914003821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914003822	active site
224914003823	phosphorylation site [posttranslational modification]
224914003824	intermolecular recognition site; other site
224914003825	dimerization interface [polypeptide binding]; other site
224914003826	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914003827	DNA binding site [nucleotide binding]
224914003828	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
224914003829	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
224914003830	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224914003831	protein binding site [polypeptide binding]; other site
224914003832	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224914003833	protein binding site [polypeptide binding]; other site
224914003834	Cytochrome C biogenesis protein; Region: CcmH; cl01179
224914003835	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
224914003836	CcmE; Region: CcmE; cl00994
224914003837	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
224914003838	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
224914003839	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
224914003840	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
224914003841	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224914003842	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
224914003843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914003844	ATP binding site [chemical binding]; other site
224914003845	Mg2+ binding site [ion binding]; other site
224914003846	G-X-G motif; other site
224914003847	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224914003848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914003849	active site
224914003850	phosphorylation site [posttranslational modification]
224914003851	intermolecular recognition site; other site
224914003852	dimerization interface [polypeptide binding]; other site
224914003853	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914003854	DNA binding site [nucleotide binding]
224914003855	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
224914003856	Putative phage tail protein; Region: Phage-tail_3; pfam13550
224914003857	NlpC/P60 family; Region: NLPC_P60; cl11438
224914003858	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
224914003859	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
224914003860	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
224914003861	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
224914003862	Phage-related minor tail protein [Function unknown]; Region: COG5281
224914003863	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
224914003864	Phage major tail protein 2; Region: Phage_tail_2; cl11463
224914003865	Phage-related protein [Function unknown]; Region: COG4695; cl01923
224914003866	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
224914003867	Uncharacterized conserved protein [Function unknown]; Region: COG5323
224914003868	Transglycosylase; Region: Transgly; cl07896
224914003869	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
224914003870	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
224914003871	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
224914003872	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
224914003873	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl15419
224914003874	Protein of unknown function (DUF1491); Region: DUF1491; cl11568
224914003875	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
224914003876	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
224914003877	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
224914003878	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224914003879	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914003880	dimer interface [polypeptide binding]; other site
224914003881	phosphorylation site [posttranslational modification]
224914003882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914003883	ATP binding site [chemical binding]; other site
224914003884	Mg2+ binding site [ion binding]; other site
224914003885	G-X-G motif; other site
224914003886	Flavin Reductases; Region: FlaRed; cl00801
224914003887	Fe-S metabolism associated domain; Region: SufE; cl00951
224914003888	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
224914003889	amidase; Provisional; Region: PRK07056
224914003890	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
224914003891	DnaA box-binding interface [nucleotide binding]; other site
224914003892	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl11561
224914003893	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
224914003894	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914003895	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
224914003896	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
224914003897	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
224914003898	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
224914003899	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914003900	motif II; other site
224914003901	xylulokinase; Provisional; Region: PRK15027
224914003902	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914003903	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
224914003904	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914003905	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
224914003906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914003907	putative substrate translocation pore; other site
224914003908	Transcriptional regulators [Transcription]; Region: FadR; COG2186
224914003909	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914003910	DNA-binding site [nucleotide binding]; DNA binding site
224914003911	FCD domain; Region: FCD; cl11656
224914003912	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
224914003913	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
224914003914	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
224914003915	Fic/DOC family; Region: Fic; cl00960
224914003916	transcription elongation factor regulatory protein; Validated; Region: PRK06342
224914003917	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
224914003918	L-asparaginase II; Region: Asparaginase_II; cl01842
224914003919	transcriptional regulator BetI; Validated; Region: PRK00767
224914003920	Helix-turn-helix domains; Region: HTH; cl00088
224914003921	choline dehydrogenase; Validated; Region: PRK02106
224914003922	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
224914003923	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
224914003924	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914003925	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
224914003926	tetrameric interface [polypeptide binding]; other site
224914003927	NAD binding site [chemical binding]; other site
224914003928	catalytic residues [active]
224914003929	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
224914003930	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
224914003931	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914003932	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
224914003933	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224914003934	DNA binding site [nucleotide binding]
224914003935	domain linker motif; other site
224914003936	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
224914003937	putative ligand binding site [chemical binding]; other site
224914003938	D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
224914003939	N- and C-terminal domain interface [polypeptide binding]; other site
224914003940	D-xylulose kinase; Region: XylB; TIGR01312
224914003941	active site
224914003942	catalytic site [active]
224914003943	metal binding site [ion binding]; metal-binding site
224914003944	xylulose binding site [chemical binding]; other site
224914003945	putative ATP binding site [chemical binding]; other site
224914003946	homodimer interface [polypeptide binding]; other site
224914003947	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
224914003948	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914003949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914003950	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
224914003951	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
224914003952	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
224914003953	DNA interaction; other site
224914003954	Metal-binding active site; metal-binding site
224914003955	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
224914003956	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
224914003957	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
224914003958	putative ligand binding site [chemical binding]; other site
224914003959	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914003960	TM-ABC transporter signature motif; other site
224914003961	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
224914003962	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
224914003963	Walker A/P-loop; other site
224914003964	ATP binding site [chemical binding]; other site
224914003965	Q-loop/lid; other site
224914003966	ABC transporter signature motif; other site
224914003967	Walker B; other site
224914003968	D-loop; other site
224914003969	H-loop/switch region; other site
224914003970	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
224914003971	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224914003972	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
224914003973	putative ADP-binding pocket [chemical binding]; other site
224914003974	N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942
224914003975	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
224914003976	dimerization interface [polypeptide binding]; other site
224914003977	putative active cleft [active]
224914003978	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
224914003979	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
224914003980	Substrate binding site; other site
224914003981	Cupin domain; Region: Cupin_2; cl09118
224914003982	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
224914003983	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
224914003984	active site
224914003985	substrate binding site [chemical binding]; other site
224914003986	metal binding site [ion binding]; metal-binding site
224914003987	putative transposase OrfB; Reviewed; Region: PHA02517
224914003988	Integrase core domain; Region: rve; cl01316
224914003989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003990	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003991	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003992	Integrase core domain; Region: rve; cl01316
224914003993	Transposase domain (DUF772); Region: DUF772; cl15789
224914003994	Transposase domain (DUF772); Region: DUF772; cl15789
224914003995	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224914003996	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
224914003997	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003998	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914003999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914004000	Integrase core domain; Region: rve; cl01316
224914004001	Integrase core domain; Region: rve_3; cl15866
224914004002	Integrase core domain; Region: rve; cl01316
224914004003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914004004	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914004005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914004006	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
224914004007	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
224914004008	NADP-binding site; other site
224914004009	homotetramer interface [polypeptide binding]; other site
224914004010	substrate binding site [chemical binding]; other site
224914004011	homodimer interface [polypeptide binding]; other site
224914004012	active site
224914004013	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
224914004014	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
224914004015	inhibitor-cofactor binding pocket; inhibition site
224914004016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914004017	catalytic residue [active]
224914004018	ABC-2 type transporter; Region: ABC2_membrane; cl11417
224914004019	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
224914004020	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
224914004021	Walker A/P-loop; other site
224914004022	ATP binding site [chemical binding]; other site
224914004023	Q-loop/lid; other site
224914004024	ABC transporter signature motif; other site
224914004025	Walker B; other site
224914004026	D-loop; other site
224914004027	H-loop/switch region; other site
224914004028	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
224914004029	active site
224914004030	substrate binding site [chemical binding]; other site
224914004031	cosubstrate binding site; other site
224914004032	catalytic site [active]
224914004033	Integrase core domain; Region: rve; cl01316
224914004034	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914004035	Integrase core domain; Region: rve; cl01316
224914004036	Helix-turn-helix domains; Region: HTH; cl00088
224914004037	DNA binding site [nucleotide binding]
224914004038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914004039	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
224914004040	Mg++ binding site [ion binding]; other site
224914004041	putative catalytic motif [active]
224914004042	putative substrate binding site [chemical binding]; other site
224914004043	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
224914004044	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
224914004045	NAD(P) binding site [chemical binding]; other site
224914004046	homodimer interface [polypeptide binding]; other site
224914004047	substrate binding site [chemical binding]; other site
224914004048	active site
224914004049	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
224914004050	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
224914004051	active site
224914004052	homotetramer interface [polypeptide binding]; other site
224914004053	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
224914004054	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
224914004055	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
224914004056	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
224914004057	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
224914004058	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
224914004059	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
224914004060	NodB motif; other site
224914004061	putative active site [active]
224914004062	putative catalytic site [active]
224914004063	pyruvate phosphate dikinase; Provisional; Region: PRK09279
224914004064	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
224914004065	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
224914004066	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
224914004067	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914004068	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
224914004069	Cation efflux family; Region: Cation_efflux; cl00316
224914004070	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
224914004071	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
224914004072	Walker A/P-loop; other site
224914004073	ATP binding site [chemical binding]; other site
224914004074	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
224914004075	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
224914004076	ABC transporter signature motif; other site
224914004077	Walker B; other site
224914004078	D-loop; other site
224914004079	H-loop/switch region; other site
224914004080	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
224914004081	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
224914004082	Protein of unknown function (DUF721); Region: DUF721; cl02324
224914004083	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
224914004084	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224914004085	minor groove reading motif; other site
224914004086	helix-hairpin-helix signature motif; other site
224914004087	substrate binding pocket [chemical binding]; other site
224914004088	active site
224914004089	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
224914004090	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
224914004091	DNA binding and oxoG recognition site [nucleotide binding]
224914004092	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
224914004093	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914004094	motif II; other site
224914004095	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
224914004096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914004097	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
224914004098	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
224914004099	Cl- selectivity filter; other site
224914004100	Cl- binding residues [ion binding]; other site
224914004101	pore gating glutamate residue; other site
224914004102	dimer interface [polypeptide binding]; other site
224914004103	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
224914004104	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
224914004105	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914004106	active site
224914004107	motif I; other site
224914004108	motif II; other site
224914004109	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
224914004110	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
224914004111	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224914004112	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
224914004113	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
224914004114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914004115	catalytic residue [active]
224914004116	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224914004117	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
224914004118	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224914004119	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224914004120	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914004121	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
224914004122	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
224914004123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
224914004124	PAS fold; Region: PAS_3; pfam08447
224914004125	putative active site [active]
224914004126	heme pocket [chemical binding]; other site
224914004127	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914004128	metal binding site [ion binding]; metal-binding site
224914004129	active site
224914004130	I-site; other site
224914004131	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224914004132	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
224914004133	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
224914004134	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
224914004135	catalytic triad [active]
224914004136	dimer interface [polypeptide binding]; other site
224914004137	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
224914004138	RNA/DNA hybrid binding site [nucleotide binding]; other site
224914004139	active site
224914004140	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
224914004141	Phosphotransferase enzyme family; Region: APH; pfam01636
224914004142	putative active site [active]
224914004143	putative substrate binding site [chemical binding]; other site
224914004144	ATP binding site [chemical binding]; other site
224914004145	LytB protein; Region: LYTB; cl00507
224914004146	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
224914004147	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
224914004148	Protein of unknown function (DUF983); Region: DUF983; cl02211
224914004149	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
224914004150	Subunit III/VIIa interface [polypeptide binding]; other site
224914004151	Phospholipid binding site [chemical binding]; other site
224914004152	Subunit I/III interface [polypeptide binding]; other site
224914004153	Subunit III/VIb interface [polypeptide binding]; other site
224914004154	Subunit III/VIa interface; other site
224914004155	Subunit III/Vb interface [polypeptide binding]; other site
224914004156	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
224914004157	UbiA prenyltransferase family; Region: UbiA; cl00337
224914004158	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
224914004159	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
224914004160	Subunit I/III interface [polypeptide binding]; other site
224914004161	D-pathway; other site
224914004162	Subunit I/VIIc interface [polypeptide binding]; other site
224914004163	Subunit I/IV interface [polypeptide binding]; other site
224914004164	Subunit I/II interface [polypeptide binding]; other site
224914004165	Low-spin heme (heme a) binding site [chemical binding]; other site
224914004166	Subunit I/VIIa interface [polypeptide binding]; other site
224914004167	Subunit I/VIa interface [polypeptide binding]; other site
224914004168	Dimer interface; other site
224914004169	Putative water exit pathway; other site
224914004170	Binuclear center (heme a3/CuB) [ion binding]; other site
224914004171	K-pathway; other site
224914004172	Subunit I/Vb interface [polypeptide binding]; other site
224914004173	Putative proton exit pathway; other site
224914004174	Subunit I/VIb interface; other site
224914004175	Subunit I/VIc interface [polypeptide binding]; other site
224914004176	Electron transfer pathway; other site
224914004177	Subunit I/VIIIb interface [polypeptide binding]; other site
224914004178	Subunit I/VIIb interface [polypeptide binding]; other site
224914004179	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
224914004180	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
224914004181	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914004182	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
224914004183	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
224914004184	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
224914004185	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
224914004186	catalytic site [active]
224914004187	G-X2-G-X-G-K; other site
224914004188	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
224914004189	hypothetical protein; Provisional; Region: PRK11820
224914004190	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
224914004191	YceG-like family; Region: YceG; pfam02618
224914004192	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
224914004193	dimerization interface [polypeptide binding]; other site
224914004194	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
224914004195	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
224914004196	dimer interface [polypeptide binding]; other site
224914004197	active site
224914004198	Phosphopantetheine attachment site; Region: PP-binding; cl09936
224914004199	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
224914004200	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
224914004201	NAD(P) binding site [chemical binding]; other site
224914004202	homotetramer interface [polypeptide binding]; other site
224914004203	homodimer interface [polypeptide binding]; other site
224914004204	active site
224914004205	Acyl transferase domain; Region: Acyl_transf_1; cl08282
224914004206	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
224914004207	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
224914004208	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
224914004209	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
224914004210	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
224914004211	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
224914004212	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
224914004213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914004214	S-adenosylmethionine binding site [chemical binding]; other site
224914004215	replicative DNA helicase; Provisional; Region: PRK09165
224914004216	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
224914004217	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
224914004218	Walker A motif; other site
224914004219	ATP binding site [chemical binding]; other site
224914004220	Walker B motif; other site
224914004221	DNA binding loops [nucleotide binding]
224914004222	DNA repair protein RadA; Provisional; Region: PRK11823
224914004223	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
224914004224	Walker A motif/ATP binding site; other site
224914004225	ATP binding site [chemical binding]; other site
224914004226	Walker B motif; other site
224914004227	Colicin V production protein; Region: Colicin_V; cl00567
224914004228	amidophosphoribosyltransferase; Provisional; Region: PRK09123
224914004229	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
224914004230	active site
224914004231	tetramer interface [polypeptide binding]; other site
224914004232	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
224914004233	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224914004234	classical (c) SDRs; Region: SDR_c; cd05233
224914004235	NAD(P) binding site [chemical binding]; other site
224914004236	active site
224914004237	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
224914004238	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
224914004239	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
224914004240	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
224914004241	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914004242	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
224914004243	ATM1 is an ABC transporter that is expressed in the mitochondria.  Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253
224914004244	Walker A/P-loop; other site
224914004245	ATP binding site [chemical binding]; other site
224914004246	Q-loop/lid; other site
224914004247	ABC transporter signature motif; other site
224914004248	Walker B; other site
224914004249	D-loop; other site
224914004250	H-loop/switch region; other site
224914004251	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
224914004252	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
224914004253	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
224914004254	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
224914004255	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
224914004256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914004257	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
224914004258	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224914004259	RNA binding surface [nucleotide binding]; other site
224914004260	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914004261	S-adenosylmethionine binding site [chemical binding]; other site
224914004262	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
224914004263	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
224914004264	TPP-binding site; other site
224914004265	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
224914004266	PYR/PP interface [polypeptide binding]; other site
224914004267	dimer interface [polypeptide binding]; other site
224914004268	TPP binding site [chemical binding]; other site
224914004269	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224914004270	Pirin-related protein [General function prediction only]; Region: COG1741
224914004271	Cupin domain; Region: Cupin_2; cl09118
224914004272	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
224914004273	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
224914004274	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
224914004275	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
224914004276	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
224914004277	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
224914004278	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
224914004279	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
224914004280	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
224914004281	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
224914004282	dimerization interface [polypeptide binding]; other site
224914004283	active site
224914004284	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
224914004285	Tetramer interface [polypeptide binding]; other site
224914004286	active site
224914004287	FMN-binding site [chemical binding]; other site
224914004288	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
224914004289	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
224914004290	putative acyl-acceptor binding pocket; other site
224914004291	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
224914004292	DNA-binding site [nucleotide binding]; DNA binding site
224914004293	RNA-binding motif; other site
224914004294	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224914004295	catalytic core [active]
224914004296	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
224914004297	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
224914004298	NAD binding site [chemical binding]; other site
224914004299	homotetramer interface [polypeptide binding]; other site
224914004300	homodimer interface [polypeptide binding]; other site
224914004301	substrate binding site [chemical binding]; other site
224914004302	active site
224914004303	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
224914004304	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224914004305	HSP70 interaction site [polypeptide binding]; other site
224914004306	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
224914004307	dimer interface [polypeptide binding]; other site
224914004308	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
224914004309	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
224914004310	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
224914004311	UbiA prenyltransferase family; Region: UbiA; cl00337
224914004312	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
224914004313	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
224914004314	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914004315	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
224914004316	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914004317	metal binding site [ion binding]; metal-binding site
224914004318	active site
224914004319	I-site; other site
224914004320	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224914004321	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
224914004322	active site
224914004323	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
224914004324	enoyl-CoA hydratase; Provisional; Region: PRK06023
224914004325	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914004326	substrate binding site [chemical binding]; other site
224914004327	oxyanion hole (OAH) forming residues; other site
224914004328	trimer interface [polypeptide binding]; other site
224914004329	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375
224914004330	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
224914004331	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
224914004332	FAD binding domain; Region: FAD_binding_4; pfam01565
224914004333	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
224914004334	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
224914004335	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
224914004336	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
224914004337	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
224914004338	dimer interface [polypeptide binding]; other site
224914004339	motif 1; other site
224914004340	active site
224914004341	motif 2; other site
224914004342	motif 3; other site
224914004343	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
224914004344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224914004345	binding surface
224914004346	TPR motif; other site
224914004347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224914004348	binding surface
224914004349	TPR motif; other site
224914004350	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
224914004351	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
224914004352	substrate binding pocket [chemical binding]; other site
224914004353	chain length determination region; other site
224914004354	substrate-Mg2+ binding site; other site
224914004355	catalytic residues [active]
224914004356	aspartate-rich region 1; other site
224914004357	active site lid residues [active]
224914004358	aspartate-rich region 2; other site
224914004359	Protein of unknown function (DUF2007); Region: DUF2007; pfam09413
224914004360	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
224914004361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914004362	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
224914004363	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
224914004364	tandem repeat interface [polypeptide binding]; other site
224914004365	oligomer interface [polypeptide binding]; other site
224914004366	active site residues [active]
224914004367	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
224914004368	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
224914004369	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
224914004370	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
224914004371	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914004372	FeS/SAM binding site; other site
224914004373	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
224914004374	RNA/DNA hybrid binding site [nucleotide binding]; other site
224914004375	active site
224914004376	Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975
224914004377	Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975
224914004378	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
224914004379	ATP synthase subunit C; Region: ATP-synt_C; cl00466
224914004380	ATP synthase A chain; Region: ATP-synt_A; cl00413
224914004381	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
224914004382	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
224914004383	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
224914004384	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
224914004385	GTP-binding protein Der; Reviewed; Region: PRK00093
224914004386	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894
224914004387	G1 box; other site
224914004388	GTP/Mg2+ binding site [chemical binding]; other site
224914004389	Switch I region; other site
224914004390	G2 box; other site
224914004391	Switch II region; other site
224914004392	G3 box; other site
224914004393	G4 box; other site
224914004394	G5 box; other site
224914004395	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895
224914004396	G1 box; other site
224914004397	GTP/Mg2+ binding site [chemical binding]; other site
224914004398	Switch I region; other site
224914004399	G2 box; other site
224914004400	G3 box; other site
224914004401	Switch II region; other site
224914004402	G4 box; other site
224914004403	G5 box; other site
224914004404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
224914004405	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
224914004406	NodB motif; other site
224914004407	putative active site [active]
224914004408	putative catalytic site [active]
224914004409	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914004410	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
224914004411	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
224914004412	Predicted membrane protein [Function unknown]; Region: COG4129
224914004413	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
224914004414	ArsC family; Region: ArsC; pfam03960
224914004415	putative catalytic residues [active]
224914004416	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
224914004417	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
224914004418	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914004419	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
224914004420	DNA binding site [nucleotide binding]
224914004421	active site
224914004422	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914004423	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914004424	NAD(P) binding site [chemical binding]; other site
224914004425	catalytic residues [active]
224914004426	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
224914004427	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
224914004428	catalytic residues [active]
224914004429	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224914004430	metal binding site 2 [ion binding]; metal-binding site
224914004431	putative DNA binding helix; other site
224914004432	metal binding site 1 [ion binding]; metal-binding site
224914004433	dimer interface [polypeptide binding]; other site
224914004434	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
224914004435	Low-spin heme binding site [chemical binding]; other site
224914004436	Putative water exit pathway; other site
224914004437	Binuclear center (active site) [active]
224914004438	Putative proton exit pathway; other site
224914004439	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
224914004440	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
224914004441	Cytochrome c; Region: Cytochrom_C; cl11414
224914004442	Cytochrome c; Region: Cytochrom_C; cl11414
224914004443	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
224914004444	4Fe-4S binding domain; Region: Fer4_5; pfam12801
224914004445	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
224914004446	FixH; Region: FixH; cl01254
224914004447	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
224914004448	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224914004449	metal-binding site [ion binding]
224914004450	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224914004451	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914004452	motif II; other site
224914004453	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
224914004454	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
224914004455	MOFRL family; Region: MOFRL; pfam05161
224914004456	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
224914004457	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
224914004458	active site
224914004459	Predicted membrane protein [Function unknown]; Region: COG3748
224914004460	Protein of unknown function (DUF989); Region: DUF989; pfam06181
224914004461	Cytochrome c; Region: Cytochrom_C; cl11414
224914004462	LysR family transcriptional regulator; Provisional; Region: PRK14997
224914004463	Helix-turn-helix domains; Region: HTH; cl00088
224914004464	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
224914004465	putative effector binding pocket; other site
224914004466	dimerization interface [polypeptide binding]; other site
224914004467	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
224914004468	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
224914004469	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
224914004470	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
224914004471	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
224914004472	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
224914004473	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
224914004474	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
224914004475	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
224914004476	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
224914004477	active site
224914004478	catalytic site [active]
224914004479	tetramer interface [polypeptide binding]; other site
224914004480	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
224914004481	hypothetical protein; Provisional; Region: PRK11171
224914004482	Cupin domain; Region: Cupin_2; cl09118
224914004483	Cupin domain; Region: Cupin_2; cl09118
224914004484	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
224914004485	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
224914004486	DctM-like transporters; Region: DctM; pfam06808
224914004487	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
224914004488	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224914004489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914004490	active site
224914004491	phosphorylation site [posttranslational modification]
224914004492	intermolecular recognition site; other site
224914004493	dimerization interface [polypeptide binding]; other site
224914004494	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224914004495	DNA binding residues [nucleotide binding]
224914004496	dimerization interface [polypeptide binding]; other site
224914004497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
224914004498	Cache domain; Region: Cache_2; cl07034
224914004499	Histidine kinase; Region: HisKA_3; pfam07730
224914004500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914004501	ATP binding site [chemical binding]; other site
224914004502	Mg2+ binding site [ion binding]; other site
224914004503	G-X-G motif; other site
224914004504	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
224914004505	multidrug efflux protein; Reviewed; Region: PRK01766
224914004506	MatE; Region: MatE; cl10513
224914004507	MatE; Region: MatE; cl10513
224914004508	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
224914004509	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
224914004510	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
224914004511	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914004512	NAD(P) binding pocket [chemical binding]; other site
224914004513	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
224914004514	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
224914004515	dimer interface [polypeptide binding]; other site
224914004516	active site
224914004517	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224914004518	catalytic residues [active]
224914004519	substrate binding site [chemical binding]; other site
224914004520	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
224914004521	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
224914004522	FAD binding pocket [chemical binding]; other site
224914004523	FAD binding motif [chemical binding]; other site
224914004524	phosphate binding motif [ion binding]; other site
224914004525	beta-alpha-beta structure motif; other site
224914004526	NAD binding pocket [chemical binding]; other site
224914004527	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
224914004528	active site
224914004529	oligomerization interface [polypeptide binding]; other site
224914004530	metal binding site [ion binding]; metal-binding site
224914004531	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
224914004532	Pantoate-beta-alanine ligase; Region: PanC; cd00560
224914004533	active site
224914004534	ATP-binding site [chemical binding]; other site
224914004535	pantoate-binding site; other site
224914004536	HXXH motif; other site
224914004537	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
224914004538	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
224914004539	LrgB-like family; Region: LrgB; cl00596
224914004540	LrgA family; Region: LrgA; cl00608
224914004541	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914004542	Helix-turn-helix domains; Region: HTH; cl00088
224914004543	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
224914004544	putative dimerization interface [polypeptide binding]; other site
224914004545	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
224914004546	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
224914004547	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
224914004548	putative active site [active]
224914004549	putative metal binding site [ion binding]; other site
224914004550	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
224914004551	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
224914004552	substrate-cofactor binding pocket; other site
224914004553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914004554	catalytic residue [active]
224914004555	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
224914004556	Sodium:solute symporter family; Region: SSF; cl00456
224914004557	PAS fold; Region: PAS_7; pfam12860
224914004558	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914004559	dimer interface [polypeptide binding]; other site
224914004560	phosphorylation site [posttranslational modification]
224914004561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914004562	ATP binding site [chemical binding]; other site
224914004563	Mg2+ binding site [ion binding]; other site
224914004564	G-X-G motif; other site
224914004565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914004566	active site
224914004567	phosphorylation site [posttranslational modification]
224914004568	intermolecular recognition site; other site
224914004569	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224914004570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914004571	active site
224914004572	phosphorylation site [posttranslational modification]
224914004573	intermolecular recognition site; other site
224914004574	dimerization interface [polypeptide binding]; other site
224914004575	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224914004576	DNA binding residues [nucleotide binding]
224914004577	dimerization interface [polypeptide binding]; other site
224914004578	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
224914004579	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
224914004580	Protein of unknown function (DUF952); Region: DUF952; cl01393
224914004581	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
224914004582	quinone interaction residues [chemical binding]; other site
224914004583	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
224914004584	active site
224914004585	catalytic residues [active]
224914004586	FMN binding site [chemical binding]; other site
224914004587	substrate binding site [chemical binding]; other site
224914004588	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
224914004589	MatE; Region: MatE; cl10513
224914004590	MatE; Region: MatE; cl10513
224914004591	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
224914004592	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
224914004593	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
224914004594	conserved cys residue [active]
224914004595	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
224914004596	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
224914004597	trimer interface [polypeptide binding]; other site
224914004598	active site
224914004599	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
224914004600	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
224914004601	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
224914004602	homodimer interface [polypeptide binding]; other site
224914004603	substrate-cofactor binding pocket; other site
224914004604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914004605	catalytic residue [active]
224914004606	Protein of unknown function (DUF525); Region: DUF525; cl01119
224914004607	Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281
224914004608	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
224914004609	dimerization interface [polypeptide binding]; other site
224914004610	domain crossover interface; other site
224914004611	redox-dependent activation switch; other site
224914004612	ornithine carbamoyltransferase; Provisional; Region: PRK00779
224914004613	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
224914004614	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914004615	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
224914004616	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224914004617	inhibitor-cofactor binding pocket; inhibition site
224914004618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914004619	catalytic residue [active]
224914004620	GcrA cell cycle regulator; Region: GcrA; cl11564
224914004621	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
224914004622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914004623	dimer interface [polypeptide binding]; other site
224914004624	phosphorylation site [posttranslational modification]
224914004625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914004626	ATP binding site [chemical binding]; other site
224914004627	Mg2+ binding site [ion binding]; other site
224914004628	G-X-G motif; other site
224914004629	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
224914004630	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
224914004631	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
224914004632	DXD motif; other site
224914004633	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
224914004634	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224914004635	substrate binding pocket [chemical binding]; other site
224914004636	membrane-bound complex binding site; other site
224914004637	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
224914004638	Protein export membrane protein; Region: SecD_SecF; cl14618
224914004639	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
224914004640	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
224914004641	Helix-turn-helix domains; Region: HTH; cl00088
224914004642	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
224914004643	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
224914004644	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
224914004645	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
224914004646	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
224914004647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914004648	motif II; other site
224914004649	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914004650	Predicted deacylase [General function prediction only]; Region: COG3608
224914004651	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
224914004652	active site
224914004653	Zn binding site [ion binding]; other site
224914004654	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
224914004655	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
224914004656	active site
224914004657	dimer interface [polypeptide binding]; other site
224914004658	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
224914004659	dimer interface [polypeptide binding]; other site
224914004660	active site
224914004661	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
224914004662	putative hydrophobic ligand binding site [chemical binding]; other site
224914004663	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
224914004664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914004665	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224914004666	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
224914004667	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
224914004668	homodimer interface [polypeptide binding]; other site
224914004669	active site
224914004670	FMN binding site [chemical binding]; other site
224914004671	substrate binding site [chemical binding]; other site
224914004672	4Fe-4S binding domain; Region: Fer4; cl02805
224914004673	4Fe-4S binding domain; Region: Fer4; cl02805
224914004674	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
224914004675	nudix motif; other site
224914004676	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
224914004677	Helix-turn-helix domains; Region: HTH; cl00088
224914004678	allantoate amidohydrolase; Reviewed; Region: PRK12893
224914004679	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
224914004680	active site
224914004681	metal binding site [ion binding]; metal-binding site
224914004682	dimer interface [polypeptide binding]; other site
224914004683	phenylhydantoinase; Validated; Region: PRK08323
224914004684	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
224914004685	tetramer interface [polypeptide binding]; other site
224914004686	active site
224914004687	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
224914004688	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224914004689	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914004690	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914004691	sensory histidine kinase AtoS; Provisional; Region: PRK11360
224914004692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914004693	ATP binding site [chemical binding]; other site
224914004694	Mg2+ binding site [ion binding]; other site
224914004695	G-X-G motif; other site
224914004696	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914004697	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
224914004698	UreF; Region: UreF; pfam01730
224914004699	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
224914004700	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
224914004701	dimer interface [polypeptide binding]; other site
224914004702	catalytic residues [active]
224914004703	urease subunit alpha; Reviewed; Region: ureC; PRK13207
224914004704	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
224914004705	subunit interactions [polypeptide binding]; other site
224914004706	active site
224914004707	flap region; other site
224914004708	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
224914004709	gamma-beta subunit interface [polypeptide binding]; other site
224914004710	alpha-beta subunit interface [polypeptide binding]; other site
224914004711	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
224914004712	alpha-gamma subunit interface [polypeptide binding]; other site
224914004713	beta-gamma subunit interface [polypeptide binding]; other site
224914004714	UreD urease accessory protein; Region: UreD; cl00530
224914004715	Helix-turn-helix domains; Region: HTH; cl00088
224914004716	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
224914004717	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
224914004718	catalytic residues [active]
224914004719	catalytic nucleophile [active]
224914004720	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
224914004721	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
224914004722	DNA-binding interface [nucleotide binding]; DNA binding site
224914004723	BRO family, N-terminal domain; Region: Bro-N; cl10591
224914004724	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
224914004725	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
224914004726	Int/Topo IB signature motif; other site
224914004727	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
224914004728	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
224914004729	hinge; other site
224914004730	active site
224914004731	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
224914004732	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
224914004733	histidinol dehydrogenase; Region: hisD; TIGR00069
224914004734	NAD binding site [chemical binding]; other site
224914004735	dimerization interface [polypeptide binding]; other site
224914004736	product binding site; other site
224914004737	substrate binding site [chemical binding]; other site
224914004738	zinc binding site [ion binding]; other site
224914004739	catalytic residues [active]
224914004740	Uncharacterised protein family (UPF0262); Region: UPF0262; cl11489
224914004741	Low molecular weight phosphatase family; Region: LMWPc; cd00115
224914004742	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
224914004743	active site
224914004744	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
224914004745	rRNA binding site [nucleotide binding]; other site
224914004746	predicted 30S ribosome binding site; other site
224914004747	Maf-like protein; Region: Maf; pfam02545
224914004748	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
224914004749	active site
224914004750	dimer interface [polypeptide binding]; other site
224914004751	Domain of unknown function (DUF329); Region: DUF329; cl01144
224914004752	TIR domain; Region: TIR; cl02060
224914004753	GcrA cell cycle regulator; Region: GcrA; cl11564
224914004754	Helix-turn-helix domains; Region: HTH; cl00088
224914004755	non-specific DNA binding site [nucleotide binding]; other site
224914004756	salt bridge; other site
224914004757	sequence-specific DNA binding site [nucleotide binding]; other site
224914004758	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
224914004759	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
224914004760	Domain of unknown function (DUF955); Region: DUF955; cl01076
224914004761	SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Region: SANT; smart00717
224914004762	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
224914004763	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375
224914004764	Helix-turn-helix domains; Region: HTH; cl00088
224914004765	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
224914004766	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
224914004767	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
224914004768	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
224914004769	integrase; Provisional; Region: PRK09692
224914004770	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
224914004771	active site
224914004772	Int/Topo IB signature motif; other site
224914004773	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
224914004774	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
224914004775	putative active site pocket [active]
224914004776	metal binding site [ion binding]; metal-binding site
224914004777	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
224914004778	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
224914004779	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
224914004780	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
224914004781	NAD binding site [chemical binding]; other site
224914004782	homotetramer interface [polypeptide binding]; other site
224914004783	homodimer interface [polypeptide binding]; other site
224914004784	active site
224914004785	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914004786	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914004787	Domain of unknown function (DUF718); Region: DUF718; cl01281
224914004788	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
224914004789	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
224914004790	active site pocket [active]
224914004791	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
224914004792	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
224914004793	Walker A/P-loop; other site
224914004794	ATP binding site [chemical binding]; other site
224914004795	Q-loop/lid; other site
224914004796	ABC transporter signature motif; other site
224914004797	Walker B; other site
224914004798	D-loop; other site
224914004799	H-loop/switch region; other site
224914004800	TOBE domain; Region: TOBE_2; cl01440
224914004801	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224914004802	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914004803	dimer interface [polypeptide binding]; other site
224914004804	conserved gate region; other site
224914004805	putative PBP binding loops; other site
224914004806	ABC-ATPase subunit interface; other site
224914004807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914004808	dimer interface [polypeptide binding]; other site
224914004809	conserved gate region; other site
224914004810	putative PBP binding loops; other site
224914004811	ABC-ATPase subunit interface; other site
224914004812	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224914004813	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914004814	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224914004815	Helix-turn-helix domains; Region: HTH; cl00088
224914004816	Bacterial transcriptional regulator; Region: IclR; pfam01614
224914004817	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
224914004818	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224914004819	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
224914004820	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
224914004821	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
224914004822	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
224914004823	Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767
224914004824	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
224914004825	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
224914004826	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
224914004827	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
224914004828	NAD(P) binding site [chemical binding]; other site
224914004829	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
224914004830	heme-binding site [chemical binding]; other site
224914004831	NMT1-like family; Region: NMT1_2; cl15260
224914004832	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
224914004833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914004834	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
224914004835	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
224914004836	Walker A/P-loop; other site
224914004837	ATP binding site [chemical binding]; other site
224914004838	Q-loop/lid; other site
224914004839	ABC transporter signature motif; other site
224914004840	Walker B; other site
224914004841	D-loop; other site
224914004842	H-loop/switch region; other site
224914004843	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
224914004844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914004845	dimer interface [polypeptide binding]; other site
224914004846	conserved gate region; other site
224914004847	putative PBP binding loops; other site
224914004848	ABC-ATPase subunit interface; other site
224914004849	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
224914004850	DNA binding residues [nucleotide binding]
224914004851	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
224914004852	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224914004853	metal-binding site [ion binding]
224914004854	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
224914004855	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224914004856	metal-binding site [ion binding]
224914004857	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224914004858	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914004859	PAS domain S-box; Region: sensory_box; TIGR00229
224914004860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
224914004861	PAS domain S-box; Region: sensory_box; TIGR00229
224914004862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224914004863	putative active site [active]
224914004864	heme pocket [chemical binding]; other site
224914004865	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914004866	metal binding site [ion binding]; metal-binding site
224914004867	active site
224914004868	I-site; other site
224914004869	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224914004870	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
224914004871	dimer interface [polypeptide binding]; other site
224914004872	substrate binding site [chemical binding]; other site
224914004873	ATP binding site [chemical binding]; other site
224914004874	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224914004875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914004876	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914004877	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
224914004878	thiS-thiF/thiG interaction site; other site
224914004879	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
224914004880	ThiS interaction site; other site
224914004881	putative active site [active]
224914004882	tetramer interface [polypeptide binding]; other site
224914004883	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
224914004884	active site
224914004885	thiamine phosphate binding site [chemical binding]; other site
224914004886	pyrophosphate binding site [ion binding]; other site
224914004887	NMT1/THI5 like; Region: NMT1; pfam09084
224914004888	NMT1-like family; Region: NMT1_2; cl15260
224914004889	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
224914004890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914004891	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
224914004892	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914004893	NAD(P) binding site [chemical binding]; other site
224914004894	catalytic residues [active]
224914004895	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914004896	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914004897	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14270
224914004898	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914004899	ATP binding site [chemical binding]; other site
224914004900	Q-loop/lid; other site
224914004901	ABC transporter signature motif; other site
224914004902	Walker B; other site
224914004903	D-loop; other site
224914004904	H-loop/switch region; other site
224914004905	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224914004906	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224914004907	DNA binding site [nucleotide binding]
224914004908	domain linker motif; other site
224914004909	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
224914004910	putative dimerization interface [polypeptide binding]; other site
224914004911	putative ligand binding site [chemical binding]; other site
224914004912	Protein of unknown function (DUF779); Region: DUF779; cl01432
224914004913	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
224914004914	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
224914004915	NAD binding site [chemical binding]; other site
224914004916	substrate binding site [chemical binding]; other site
224914004917	catalytic Zn binding site [ion binding]; other site
224914004918	tetramer interface [polypeptide binding]; other site
224914004919	structural Zn binding site [ion binding]; other site
224914004920	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
224914004921	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914004922	NAD(P) binding site [chemical binding]; other site
224914004923	catalytic residues [active]
224914004924	GAF domain; Region: GAF; cl00853
224914004925	Helix-turn-helix domains; Region: HTH; cl00088
224914004926	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
224914004927	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914004928	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
224914004929	Helix-turn-helix domains; Region: HTH; cl00088
224914004930	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914004931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224914004932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
224914004933	active site
224914004934	dimerization interface [polypeptide binding]; other site
224914004935	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224914004936	DNA binding residues [nucleotide binding]
224914004937	dimerization interface [polypeptide binding]; other site
224914004938	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224914004939	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
224914004940	ligand binding site [chemical binding]; other site
224914004941	flexible hinge region; other site
224914004942	Helix-turn-helix domains; Region: HTH; cl00088
224914004943	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
224914004944	active site
224914004945	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
224914004946	CysN_ATPS subfamily.  CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes.  ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate.  CysD, which...; Region: CysN_ATPS; cd04166
224914004947	CysD dimerization site [polypeptide binding]; other site
224914004948	G1 box; other site
224914004949	putative GEF interaction site [polypeptide binding]; other site
224914004950	GTP/Mg2+ binding site [chemical binding]; other site
224914004951	Switch I region; other site
224914004952	G2 box; other site
224914004953	G3 box; other site
224914004954	Switch II region; other site
224914004955	G4 box; other site
224914004956	G5 box; other site
224914004957	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
224914004958	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
224914004959	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
224914004960	ligand-binding site [chemical binding]; other site
224914004961	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
224914004962	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
224914004963	Active Sites [active]
224914004964	aminotransferase; Provisional; Region: PRK06105
224914004965	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224914004966	inhibitor-cofactor binding pocket; inhibition site
224914004967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914004968	catalytic residue [active]
224914004969	Autoinducer binding domain; Region: Autoind_bind; pfam03472
224914004970	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224914004971	DNA binding residues [nucleotide binding]
224914004972	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
224914004973	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
224914004974	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
224914004975	substrate binding pocket [chemical binding]; other site
224914004976	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
224914004977	B12 binding site [chemical binding]; other site
224914004978	cobalt ligand [ion binding]; other site
224914004979	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
224914004980	BA14K-like protein; Region: BA14K; pfam07886
224914004981	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
224914004982	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
224914004983	active site
224914004984	DNA binding site [nucleotide binding]
224914004985	Stress responsive A/B Barrel Domain; Region: Dabb; cl06768
224914004986	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
224914004987	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
224914004988	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
224914004989	Active Sites [active]
224914004990	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
224914004991	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224914004992	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224914004993	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
224914004994	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
224914004995	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
224914004996	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
224914004997	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
224914004998	Predicted methyltransferases [General function prediction only]; Region: COG0313
224914004999	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
224914005000	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
224914005001	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914005002	FeS/SAM binding site; other site
224914005003	HemN C-terminal region; Region: HemN_C; pfam06969
224914005004	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
224914005005	active site
224914005006	dimerization interface [polypeptide binding]; other site
224914005007	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
224914005008	metal binding site [ion binding]; metal-binding site
224914005009	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
224914005010	ribonuclease PH; Reviewed; Region: rph; PRK00173
224914005011	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
224914005012	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
224914005013	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
224914005014	HrcA protein C terminal domain; Region: HrcA; pfam01628
224914005015	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
224914005016	dimer interface [polypeptide binding]; other site
224914005017	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
224914005018	Predicted membrane protein [Function unknown]; Region: COG2860
224914005019	UPF0126 domain; Region: UPF0126; pfam03458
224914005020	UPF0126 domain; Region: UPF0126; pfam03458
224914005021	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168
224914005022	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224914005023	substrate binding site [chemical binding]; other site
224914005024	ATP binding site [chemical binding]; other site
224914005025	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
224914005026	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
224914005027	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224914005028	minor groove reading motif; other site
224914005029	helix-hairpin-helix signature motif; other site
224914005030	substrate binding pocket [chemical binding]; other site
224914005031	active site
224914005032	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
224914005033	Integral membrane protein (DUF2244); Region: DUF2244; cl02302
224914005034	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
224914005035	putative dimer interface [polypeptide binding]; other site
224914005036	Protein of unknown function (DUF1150); Region: DUF1150; cl11577
224914005037	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
224914005038	active site
224914005039	phosphorylation site [posttranslational modification]
224914005040	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
224914005041	30S subunit binding site; other site
224914005042	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
224914005043	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
224914005044	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
224914005045	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
224914005046	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
224914005047	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
224914005048	Walker A/P-loop; other site
224914005049	ATP binding site [chemical binding]; other site
224914005050	Q-loop/lid; other site
224914005051	ABC transporter signature motif; other site
224914005052	Walker B; other site
224914005053	D-loop; other site
224914005054	H-loop/switch region; other site
224914005055	OstA-like protein; Region: OstA; cl00844
224914005056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
224914005057	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
224914005058	tandem repeat interface [polypeptide binding]; other site
224914005059	oligomer interface [polypeptide binding]; other site
224914005060	active site residues [active]
224914005061	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
224914005062	IHF dimer interface [polypeptide binding]; other site
224914005063	IHF - DNA interface [nucleotide binding]; other site
224914005064	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
224914005065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914005066	S-adenosylmethionine binding site [chemical binding]; other site
224914005067	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
224914005068	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
224914005069	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
224914005070	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
224914005071	lipoprotein signal peptidase; Provisional; Region: PRK14787
224914005072	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914005073	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
224914005074	MutS domain I; Region: MutS_I; pfam01624
224914005075	MutS domain II; Region: MutS_II; pfam05188
224914005076	MutS family domain IV; Region: MutS_IV; pfam05190
224914005077	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
224914005078	Walker A/P-loop; other site
224914005079	ATP binding site [chemical binding]; other site
224914005080	Q-loop/lid; other site
224914005081	ABC transporter signature motif; other site
224914005082	Walker B; other site
224914005083	D-loop; other site
224914005084	H-loop/switch region; other site
224914005085	Malic enzyme, N-terminal domain; Region: malic; pfam00390
224914005086	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
224914005087	putative NAD(P) binding site [chemical binding]; other site
224914005088	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
224914005089	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
224914005090	PII uridylyl-transferase; Provisional; Region: PRK05092
224914005091	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
224914005092	metal binding triad; other site
224914005093	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
224914005094	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
224914005095	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
224914005096	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
224914005097	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
224914005098	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
224914005099	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
224914005100	active site
224914005101	HIGH motif; other site
224914005102	dimer interface [polypeptide binding]; other site
224914005103	KMSKS motif; other site
224914005104	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
224914005105	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
224914005106	NifU-like domain; Region: NifU; cl00484
224914005107	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914005108	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
224914005109	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
224914005110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914005111	active site
224914005112	phosphorylation site [posttranslational modification]
224914005113	intermolecular recognition site; other site
224914005114	dimerization interface [polypeptide binding]; other site
224914005115	Helix-turn-helix domains; Region: HTH; cl00088
224914005116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914005117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914005118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224914005119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914005120	ATP binding site [chemical binding]; other site
224914005121	Mg2+ binding site [ion binding]; other site
224914005122	G-X-G motif; other site
224914005123	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
224914005124	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005125	ATP binding site [chemical binding]; other site
224914005126	putative Mg++ binding site [ion binding]; other site
224914005127	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914005128	nucleotide binding region [chemical binding]; other site
224914005129	ATP-binding site [chemical binding]; other site
224914005130	Helicase associated domain (HA2); Region: HA2; cl04503
224914005131	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
224914005132	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
224914005133	substrate binding site [chemical binding]; other site
224914005134	catalytic Zn binding site [ion binding]; other site
224914005135	NAD binding site [chemical binding]; other site
224914005136	structural Zn binding site [ion binding]; other site
224914005137	dimer interface [polypeptide binding]; other site
224914005138	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224914005139	Coenzyme A binding pocket [chemical binding]; other site
224914005140	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
224914005141	Predicted esterase [General function prediction only]; Region: COG0627
224914005142	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914005143	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
224914005144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914005145	Mg2+ binding site [ion binding]; other site
224914005146	G-X-G motif; other site
224914005147	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
224914005148	anchoring element; other site
224914005149	dimer interface [polypeptide binding]; other site
224914005150	ATP binding site [chemical binding]; other site
224914005151	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
224914005152	active site
224914005153	putative metal-binding site [ion binding]; other site
224914005154	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
224914005155	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
224914005156	DEAD-like helicases superfamily; Region: DEXDc; smart00487
224914005157	ATP binding site [chemical binding]; other site
224914005158	Mg++ binding site [ion binding]; other site
224914005159	motif III; other site
224914005160	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914005161	nucleotide binding region [chemical binding]; other site
224914005162	ATP-binding site [chemical binding]; other site
224914005163	ATP-dependent helicase HepA; Validated; Region: PRK04914
224914005164	DbpA RNA binding domain; Region: DbpA; pfam03880
224914005165	DNA polymerase I; Region: pola; TIGR00593
224914005166	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
224914005167	active site
224914005168	metal binding site 1 [ion binding]; metal-binding site
224914005169	putative 5' ssDNA interaction site; other site
224914005170	metal binding site 3; metal-binding site
224914005171	metal binding site 2 [ion binding]; metal-binding site
224914005172	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
224914005173	putative DNA binding site [nucleotide binding]; other site
224914005174	putative metal binding site [ion binding]; other site
224914005175	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
224914005176	active site
224914005177	catalytic site [active]
224914005178	substrate binding site [chemical binding]; other site
224914005179	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
224914005180	active site
224914005181	DNA binding site [nucleotide binding]
224914005182	catalytic site [active]
224914005183	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
224914005184	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
224914005185	metal binding site [ion binding]; metal-binding site
224914005186	putative dimer interface [polypeptide binding]; other site
224914005187	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
224914005188	putative active site [active]
224914005189	catalytic site [active]
224914005190	putative substrate binding site [chemical binding]; other site
224914005191	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
224914005192	Surface antigen; Region: Surface_Ag_2; cl01155
224914005193	Transglycosylase; Region: Transgly; cl07896
224914005194	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
224914005195	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
224914005196	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224914005197	classical (c) SDRs; Region: SDR_c; cd05233
224914005198	NAD(P) binding site [chemical binding]; other site
224914005199	active site
224914005200	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224914005201	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
224914005202	putative substrate binding site [chemical binding]; other site
224914005203	putative ATP binding site [chemical binding]; other site
224914005204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914005205	S-adenosylmethionine binding site [chemical binding]; other site
224914005206	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
224914005207	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
224914005208	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
224914005209	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
224914005210	active site
224914005211	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
224914005212	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
224914005213	Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091
224914005214	Putative carbohydrate binding domain; Region: CBM_X; cl05621
224914005215	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
224914005216	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
224914005217	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
224914005218	Putative carbohydrate binding domain; Region: CBM_X; cl05621
224914005219	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
224914005220	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
224914005221	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
224914005222	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
224914005223	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
224914005224	Walker A/P-loop; other site
224914005225	ATP binding site [chemical binding]; other site
224914005226	Q-loop/lid; other site
224914005227	ABC transporter signature motif; other site
224914005228	Walker B; other site
224914005229	D-loop; other site
224914005230	H-loop/switch region; other site
224914005231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914005232	dimer interface [polypeptide binding]; other site
224914005233	conserved gate region; other site
224914005234	putative PBP binding loops; other site
224914005235	ABC-ATPase subunit interface; other site
224914005236	sulfate ABC transporter, permease protein CysT; Region: permease_CysT; TIGR02139
224914005237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914005238	dimer interface [polypeptide binding]; other site
224914005239	conserved gate region; other site
224914005240	putative PBP binding loops; other site
224914005241	ABC-ATPase subunit interface; other site
224914005242	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914005243	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
224914005244	putative active site [active]
224914005245	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
224914005246	Helix-turn-helix domains; Region: HTH; cl00088
224914005247	response regulator; Provisional; Region: PRK13435
224914005248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
224914005249	Dehydratase family; Region: ILVD_EDD; cl00340
224914005250	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
224914005251	catalytic residues [active]
224914005252	central insert; other site
224914005253	Heme exporter protein D (CcmD); Region: CcmD; cl11475
224914005254	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
224914005255	CcmB protein; Region: CcmB; cl01016
224914005256	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
224914005257	CcmA, the ATP-binding component of the bacterial CcmAB transporter.  The CCM family is involved in bacterial cytochrome c biogenesis.  Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH).  CcmE...; Region: ABC_CcmA_heme_exporter; cd03231
224914005258	Walker A/P-loop; other site
224914005259	ATP binding site [chemical binding]; other site
224914005260	Q-loop/lid; other site
224914005261	ABC transporter signature motif; other site
224914005262	Walker B; other site
224914005263	D-loop; other site
224914005264	H-loop/switch region; other site
224914005265	aconitate hydratase; Validated; Region: PRK09277
224914005266	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
224914005267	substrate binding site [chemical binding]; other site
224914005268	ligand binding site [chemical binding]; other site
224914005269	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
224914005270	substrate binding site [chemical binding]; other site
224914005271	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
224914005272	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
224914005273	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224914005274	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224914005275	Coenzyme A binding pocket [chemical binding]; other site
224914005276	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
224914005277	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
224914005278	FtsX-like permease family; Region: FtsX; pfam02687
224914005279	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
224914005280	active site
224914005281	catalytic triad [active]
224914005282	oxyanion hole [active]
224914005283	switch loop; other site
224914005284	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
224914005285	2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834
224914005286	2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834
224914005287	Low molecular weight phosphatase family; Region: LMWPc; cd00115
224914005288	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
224914005289	active site
224914005290	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
224914005291	aromatic arch; other site
224914005292	DCoH dimer interaction site [polypeptide binding]; other site
224914005293	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
224914005294	DCoH tetramer interaction site [polypeptide binding]; other site
224914005295	substrate binding site [chemical binding]; other site
224914005296	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
224914005297	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
224914005298	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
224914005299	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367
224914005300	LysE type translocator; Region: LysE; cl00565
224914005301	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
224914005302	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
224914005303	ANP binding site [chemical binding]; other site
224914005304	Substrate Binding Site II [chemical binding]; other site
224914005305	Substrate Binding Site I [chemical binding]; other site
224914005306	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
224914005307	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
224914005308	Hep_Hag; Region: Hep_Hag; pfam05658
224914005309	Haemagglutinin; Region: HIM; pfam05662
224914005310	Haemagglutinin; Region: HIM; pfam05662
224914005311	YadA-like C-terminal region; Region: YadA; pfam03895
224914005312	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
224914005313	Haemagglutinin; Region: HIM; pfam05662
224914005314	Haemagglutinin; Region: HIM; pfam05662
224914005315	Cell division inhibitor SulA; Region: SulA; cl01880
224914005316	DNA Polymerase Y-family; Region: PolY_like; cd03468
224914005317	active site
224914005318	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
224914005319	DNA binding site [nucleotide binding]
224914005320	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
224914005321	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
224914005322	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
224914005323	generic binding surface II; other site
224914005324	generic binding surface I; other site
224914005325	Haemolysin-III related; Region: HlyIII; cl03831
224914005326	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
224914005327	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224914005328	catalytic residue [active]
224914005329	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
224914005330	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
224914005331	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005332	active site
224914005333	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
224914005334	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914005335	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914005336	Helix-turn-helix domains; Region: HTH; cl00088
224914005337	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
224914005338	putative effector binding pocket; other site
224914005339	putative dimerization interface [polypeptide binding]; other site
224914005340	phosphoglucomutase; Region: PLN02307
224914005341	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
224914005342	substrate binding site [chemical binding]; other site
224914005343	dimer interface [polypeptide binding]; other site
224914005344	active site
224914005345	metal binding site [ion binding]; metal-binding site
224914005346	Domain of unknown function DUF59; Region: DUF59; cl00941
224914005347	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
224914005348	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
224914005349	Walker A motif; other site
224914005350	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005351	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
224914005352	dimer interface [polypeptide binding]; other site
224914005353	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914005354	active site
224914005355	metal binding site [ion binding]; metal-binding site
224914005356	glutathione binding site [chemical binding]; other site
224914005357	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
224914005358	Protein of unknown function (DUF461); Region: DUF461; cl01071
224914005359	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914005360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
224914005361	Family of unknown function (DUF490); Region: DUF490; pfam04357
224914005362	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
224914005363	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
224914005364	Surface antigen; Region: Bac_surface_Ag; cl03097
224914005365	Bacterial SH3 domain; Region: SH3_3; cl02551
224914005366	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
224914005367	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
224914005368	Subunit I/III interface [polypeptide binding]; other site
224914005369	Subunit III/IV interface [polypeptide binding]; other site
224914005370	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
224914005371	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
224914005372	D-pathway; other site
224914005373	Putative ubiquinol binding site [chemical binding]; other site
224914005374	Low-spin heme (heme b) binding site [chemical binding]; other site
224914005375	Putative water exit pathway; other site
224914005376	Binuclear center (heme o3/CuB) [ion binding]; other site
224914005377	K-pathway; other site
224914005378	Putative proton exit pathway; other site
224914005379	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
224914005380	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914005381	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
224914005382	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
224914005383	putative MPT binding site; other site
224914005384	Cytochrome c; Region: Cytochrom_C; cl11414
224914005385	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
224914005386	Ligand binding site; other site
224914005387	oligomer interface; other site
224914005388	prephenate dehydratase; Provisional; Region: PRK11899
224914005389	Prephenate dehydratase; Region: PDT; pfam00800
224914005390	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
224914005391	putative L-Phe binding site [chemical binding]; other site
224914005392	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
224914005393	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
224914005394	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
224914005395	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
224914005396	putative NADH binding site [chemical binding]; other site
224914005397	putative active site [active]
224914005398	nudix motif; other site
224914005399	putative metal binding site [ion binding]; other site
224914005400	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
224914005401	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
224914005402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914005403	Walker A motif; other site
224914005404	ATP binding site [chemical binding]; other site
224914005405	Walker B motif; other site
224914005406	arginine finger; other site
224914005407	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
224914005408	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
224914005409	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
224914005410	recombination protein RecR; Reviewed; Region: recR; PRK00076
224914005411	RecR protein; Region: RecR; pfam02132
224914005412	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
224914005413	putative active site [active]
224914005414	putative metal-binding site [ion binding]; other site
224914005415	tetramer interface [polypeptide binding]; other site
224914005416	lytic murein transglycosylase; Region: MltB_2; TIGR02283
224914005417	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
224914005418	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224914005419	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
224914005420	Helix-turn-helix domains; Region: HTH; cl00088
224914005421	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
224914005422	putative dimerization interface [polypeptide binding]; other site
224914005423	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
224914005424	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
224914005425	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
224914005426	RNA binding site [nucleotide binding]; other site
224914005427	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
224914005428	RNA binding site [nucleotide binding]; other site
224914005429	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
224914005430	RNA binding site [nucleotide binding]; other site
224914005431	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224914005432	RNA binding site [nucleotide binding]; other site
224914005433	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224914005434	RNA binding site [nucleotide binding]; other site
224914005435	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
224914005436	RNA binding site [nucleotide binding]; other site
224914005437	cytidylate kinase; Provisional; Region: cmk; PRK00023
224914005438	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
224914005439	CMP-binding site; other site
224914005440	The sites determining sugar specificity; other site
224914005441	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
224914005442	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
224914005443	hinge; other site
224914005444	active site
224914005445	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; cl15701
224914005446	OpgC protein; Region: OpgC_C; cl00792
224914005447	Acyltransferase family; Region: Acyl_transf_3; pfam01757
224914005448	CHRD domain; Region: CHRD; cl06473
224914005449	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
224914005450	AMP-binding enzyme; Region: AMP-binding; cl15778
224914005451	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
224914005452	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
224914005453	isovaleryl-CoA dehydrogenase; Region: PLN02519
224914005454	substrate binding site [chemical binding]; other site
224914005455	FAD binding site [chemical binding]; other site
224914005456	catalytic base [active]
224914005457	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
224914005458	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
224914005459	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224914005460	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914005461	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
224914005462	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224914005463	carboxyltransferase (CT) interaction site; other site
224914005464	biotinylation site [posttranslational modification]; other site
224914005465	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
224914005466	active site
224914005467	catalytic residues [active]
224914005468	metal binding site [ion binding]; metal-binding site
224914005469	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914005470	substrate binding site [chemical binding]; other site
224914005471	oxyanion hole (OAH) forming residues; other site
224914005472	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914005473	trimer interface [polypeptide binding]; other site
224914005474	enoyl-CoA hydratase; Provisional; Region: PRK06210
224914005475	leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404
224914005476	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
224914005477	dimerization interface [polypeptide binding]; other site
224914005478	ligand binding site [chemical binding]; other site
224914005479	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
224914005480	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
224914005481	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
224914005482	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
224914005483	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
224914005484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914005485	dimer interface [polypeptide binding]; other site
224914005486	conserved gate region; other site
224914005487	putative PBP binding loops; other site
224914005488	ABC-ATPase subunit interface; other site
224914005489	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
224914005490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914005491	dimer interface [polypeptide binding]; other site
224914005492	conserved gate region; other site
224914005493	putative PBP binding loops; other site
224914005494	ABC-ATPase subunit interface; other site
224914005495	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
224914005496	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914005497	Walker A/P-loop; other site
224914005498	ATP binding site [chemical binding]; other site
224914005499	Q-loop/lid; other site
224914005500	ABC transporter signature motif; other site
224914005501	Walker B; other site
224914005502	D-loop; other site
224914005503	H-loop/switch region; other site
224914005504	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914005505	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914005506	Walker A/P-loop; other site
224914005507	ATP binding site [chemical binding]; other site
224914005508	Q-loop/lid; other site
224914005509	ABC transporter signature motif; other site
224914005510	Walker B; other site
224914005511	D-loop; other site
224914005512	H-loop/switch region; other site
224914005513	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914005514	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
224914005515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914005516	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
224914005517	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
224914005518	ATP binding site [chemical binding]; other site
224914005519	substrate interface [chemical binding]; other site
224914005520	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
224914005521	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
224914005522	Walker A/P-loop; other site
224914005523	ATP binding site [chemical binding]; other site
224914005524	Q-loop/lid; other site
224914005525	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005526	ABC transporter signature motif; other site
224914005527	Walker B; other site
224914005528	D-loop; other site
224914005529	H-loop/switch region; other site
224914005530	DNA polymerase III subunit beta; Validated; Region: PRK05643
224914005531	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
224914005532	putative DNA binding surface [nucleotide binding]; other site
224914005533	dimer interface [polypeptide binding]; other site
224914005534	beta-clamp/clamp loader binding surface; other site
224914005535	beta-clamp/translesion DNA polymerase binding surface; other site
224914005536	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
224914005537	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005538	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
224914005539	DnaA box-binding interface [nucleotide binding]; other site
224914005540	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
224914005541	enoyl-CoA hydratase; Provisional; Region: PRK05862
224914005542	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914005543	substrate binding site [chemical binding]; other site
224914005544	oxyanion hole (OAH) forming residues; other site
224914005545	trimer interface [polypeptide binding]; other site
224914005546	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
224914005547	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
224914005548	DNA binding site [nucleotide binding]
224914005549	catalytic residue [active]
224914005550	H2TH interface [polypeptide binding]; other site
224914005551	putative catalytic residues [active]
224914005552	turnover-facilitating residue; other site
224914005553	intercalation triad [nucleotide binding]; other site
224914005554	8OG recognition residue [nucleotide binding]; other site
224914005555	putative reading head residues; other site
224914005556	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
224914005557	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
224914005558	multifunctional aminopeptidase A; Provisional; Region: PRK00913
224914005559	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
224914005560	interface (dimer of trimers) [polypeptide binding]; other site
224914005561	Substrate-binding/catalytic site; other site
224914005562	Zn-binding sites [ion binding]; other site
224914005563	Helix-turn-helix domains; Region: HTH; cl00088
224914005564	NlpC/P60 family; Region: NLPC_P60; cl11438
224914005565	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224914005566	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
224914005567	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914005568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
224914005569	Bacterial SH3 domain; Region: SH3_3; cl02551
224914005570	Bacterial SH3 domain; Region: SH3_3; cl02551
224914005571	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
224914005572	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224914005573	metal binding site 2 [ion binding]; metal-binding site
224914005574	putative DNA binding helix; other site
224914005575	metal binding site 1 [ion binding]; metal-binding site
224914005576	dimer interface [polypeptide binding]; other site
224914005577	structural Zn2+ binding site [ion binding]; other site
224914005578	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
224914005579	active site 1 [active]
224914005580	dimer interface [polypeptide binding]; other site
224914005581	active site 2 [active]
224914005582	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
224914005583	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
224914005584	dimer interface [polypeptide binding]; other site
224914005585	active site
224914005586	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
224914005587	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914005588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914005589	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
224914005590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914005591	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
224914005592	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
224914005593	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
224914005594	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
224914005595	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
224914005596	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
224914005597	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
224914005598	putative nucleic acid binding region [nucleotide binding]; other site
224914005599	G-X-X-G motif; other site
224914005600	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
224914005601	RNA binding site [nucleotide binding]; other site
224914005602	domain interface; other site
224914005603	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
224914005604	16S/18S rRNA binding site [nucleotide binding]; other site
224914005605	S13e-L30e interaction site [polypeptide binding]; other site
224914005606	25S rRNA binding site [nucleotide binding]; other site
224914005607	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
224914005608	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
224914005609	RNA binding site [nucleotide binding]; other site
224914005610	active site
224914005611	Ribosome-binding factor A; Region: RBFA; cl00542
224914005612	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
224914005613	translation initiation factor IF-2; Region: IF-2; TIGR00487
224914005614	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
224914005615	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases; Region: IF2_eIF5B; cd01887
224914005616	G1 box; other site
224914005617	putative GEF interaction site [polypeptide binding]; other site
224914005618	GTP/Mg2+ binding site [chemical binding]; other site
224914005619	Switch I region; other site
224914005620	G2 box; other site
224914005621	G3 box; other site
224914005622	Switch II region; other site
224914005623	G4 box; other site
224914005624	G5 box; other site
224914005625	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
224914005626	Translation-initiation factor 2; Region: IF-2; pfam11987
224914005627	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
224914005628	hypothetical protein; Provisional; Region: PRK09190
224914005629	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
224914005630	putative RNA binding cleft [nucleotide binding]; other site
224914005631	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
224914005632	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
224914005633	NusA N-terminal domain; Region: NusA_N; pfam08529
224914005634	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
224914005635	RNA binding site [nucleotide binding]; other site
224914005636	homodimer interface [polypeptide binding]; other site
224914005637	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
224914005638	G-X-X-G motif; other site
224914005639	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
224914005640	G-X-X-G motif; other site
224914005641	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
224914005642	ribosome maturation protein RimP; Reviewed; Region: PRK00092
224914005643	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
224914005644	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
224914005645	Sm1 motif; other site
224914005646	D3 - B interaction site; other site
224914005647	D1 - D2 interaction site; other site
224914005648	Hfq - Hfq interaction site; other site
224914005649	RNA binding pocket [nucleotide binding]; other site
224914005650	Sm2 motif; other site
224914005651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914005652	S-adenosylmethionine synthetase; Validated; Region: PRK05250
224914005653	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
224914005654	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
224914005655	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
224914005656	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224914005657	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224914005658	non-specific DNA binding site [nucleotide binding]; other site
224914005659	salt bridge; other site
224914005660	sequence-specific DNA binding site [nucleotide binding]; other site
224914005661	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
224914005662	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
224914005663	putative active site [active]
224914005664	catalytic triad [active]
224914005665	putative dimer interface [polypeptide binding]; other site
224914005666	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
224914005667	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224914005668	Transporter associated domain; Region: CorC_HlyC; cl08393
224914005669	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
224914005670	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005671	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
224914005672	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224914005673	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914005674	FeS/SAM binding site; other site
224914005675	TRAM domain; Region: TRAM; cl01282
224914005676	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
224914005677	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
224914005678	putative acyl-acceptor binding pocket; other site
224914005679	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
224914005680	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
224914005681	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
224914005682	Ferritin-like domain; Region: Ferritin; pfam00210
224914005683	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
224914005684	dimerization interface [polypeptide binding]; other site
224914005685	DPS ferroxidase diiron center [ion binding]; other site
224914005686	ion pore; other site
224914005687	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
224914005688	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
224914005689	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
224914005690	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
224914005691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914005692	active site
224914005693	phosphorylation site [posttranslational modification]
224914005694	intermolecular recognition site; other site
224914005695	dimerization interface [polypeptide binding]; other site
224914005696	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914005697	DNA binding site [nucleotide binding]
224914005698	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
224914005699	PhoU domain; Region: PhoU; pfam01895
224914005700	PhoU domain; Region: PhoU; pfam01895
224914005701	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
224914005702	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
224914005703	Walker A/P-loop; other site
224914005704	ATP binding site [chemical binding]; other site
224914005705	Q-loop/lid; other site
224914005706	ABC transporter signature motif; other site
224914005707	Walker B; other site
224914005708	D-loop; other site
224914005709	H-loop/switch region; other site
224914005710	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
224914005711	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
224914005712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914005713	dimer interface [polypeptide binding]; other site
224914005714	conserved gate region; other site
224914005715	putative PBP binding loops; other site
224914005716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914005717	ABC-ATPase subunit interface; other site
224914005718	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
224914005719	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
224914005720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914005721	dimer interface [polypeptide binding]; other site
224914005722	conserved gate region; other site
224914005723	putative PBP binding loops; other site
224914005724	ABC-ATPase subunit interface; other site
224914005725	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914005726	Protein of unknown function (DUF454); Region: DUF454; cl01063
224914005727	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
224914005728	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
224914005729	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914005730	Walker A motif; other site
224914005731	ATP binding site [chemical binding]; other site
224914005732	Walker B motif; other site
224914005733	arginine finger; other site
224914005734	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
224914005735	glutathione synthetase; Provisional; Region: PRK05246
224914005736	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
224914005737	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
224914005738	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
224914005739	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
224914005740	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
224914005741	active site
224914005742	dimer interface [polypeptide binding]; other site
224914005743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914005744	chaperone protein DnaJ; Provisional; Region: PRK10767
224914005745	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224914005746	HSP70 interaction site [polypeptide binding]; other site
224914005747	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
224914005748	substrate binding site [polypeptide binding]; other site
224914005749	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
224914005750	Zn binding sites [ion binding]; other site
224914005751	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
224914005752	dimer interface [polypeptide binding]; other site
224914005753	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
224914005754	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914005755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914005756	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
224914005757	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
224914005758	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
224914005759	putative tRNA-binding site [nucleotide binding]; other site
224914005760	B3/4 domain; Region: B3_4; cl11458
224914005761	tRNA synthetase B5 domain; Region: B5; cl08394
224914005762	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
224914005763	dimer interface [polypeptide binding]; other site
224914005764	motif 1; other site
224914005765	motif 3; other site
224914005766	motif 2; other site
224914005767	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
224914005768	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
224914005769	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
224914005770	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
224914005771	dimer interface [polypeptide binding]; other site
224914005772	motif 1; other site
224914005773	active site
224914005774	motif 2; other site
224914005775	motif 3; other site
224914005776	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
224914005777	active site
224914005778	ATP binding site [chemical binding]; other site
224914005779	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
224914005780	23S rRNA binding site [nucleotide binding]; other site
224914005781	L21 binding site [polypeptide binding]; other site
224914005782	L13 binding site [polypeptide binding]; other site
224914005783	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
224914005784	Phospholipid methyltransferase; Region: PEMT; cl00763
224914005785	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
224914005786	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
224914005787	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224914005788	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
224914005789	Permease family; Region: Xan_ur_permease; cl00967
224914005790	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
224914005791	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
224914005792	Protein of unknown function DUF45; Region: DUF45; cl00636
224914005793	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
224914005794	putative active site [active]
224914005795	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
224914005796	active site
224914005797	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
224914005798	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
224914005799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914005800	catalytic residue [active]
224914005801	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
224914005802	substrate binding site [chemical binding]; other site
224914005803	active site
224914005804	catalytic residues [active]
224914005805	heterodimer interface [polypeptide binding]; other site
224914005806	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
224914005807	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
224914005808	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
224914005809	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
224914005810	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224914005811	catalytic residues [active]
224914005812	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
224914005813	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005814	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005815	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
224914005816	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
224914005817	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
224914005818	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
224914005819	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
224914005820	Substrate binding site; other site
224914005821	metal-binding site
224914005822	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
224914005823	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
224914005824	PAS fold; Region: PAS_7; pfam12860
224914005825	PAS fold; Region: PAS_7; pfam12860
224914005826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914005827	dimer interface [polypeptide binding]; other site
224914005828	phosphorylation site [posttranslational modification]
224914005829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914005830	ATP binding site [chemical binding]; other site
224914005831	Mg2+ binding site [ion binding]; other site
224914005832	G-X-G motif; other site
224914005833	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
224914005834	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
224914005835	oligomerization interface [polypeptide binding]; other site
224914005836	active site
224914005837	NAD+ binding site [chemical binding]; other site
224914005838	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
224914005839	dimerization domain swap beta strand [polypeptide binding]; other site
224914005840	regulatory protein interface [polypeptide binding]; other site
224914005841	active site
224914005842	regulatory phosphorylation site [posttranslational modification]; other site
224914005843	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
224914005844	active pocket/dimerization site; other site
224914005845	active site
224914005846	phosphorylation site [posttranslational modification]
224914005847	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
224914005848	Hpr binding site; other site
224914005849	active site
224914005850	homohexamer subunit interaction site [polypeptide binding]; other site
224914005851	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
224914005852	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
224914005853	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224914005854	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
224914005855	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914005856	dimer interface [polypeptide binding]; other site
224914005857	phosphorylation site [posttranslational modification]
224914005858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914005859	ATP binding site [chemical binding]; other site
224914005860	Mg2+ binding site [ion binding]; other site
224914005861	G-X-G motif; other site
224914005862	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
224914005863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914005864	active site
224914005865	phosphorylation site [posttranslational modification]
224914005866	intermolecular recognition site; other site
224914005867	dimerization interface [polypeptide binding]; other site
224914005868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914005869	DNA binding site [nucleotide binding]
224914005870	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
224914005871	active site
224914005872	substrate-binding site [chemical binding]; other site
224914005873	metal-binding site [ion binding]
224914005874	ATP binding site [chemical binding]; other site
224914005875	RF-1 domain; Region: RF-1; cl02875
224914005876	pantothenate kinase; Provisional; Region: PRK05439
224914005877	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
224914005878	ATP-binding site [chemical binding]; other site
224914005879	CoA-binding site [chemical binding]; other site
224914005880	Mg2+-binding site [ion binding]; other site
224914005881	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
224914005882	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
224914005883	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
224914005884	substrate binding site [chemical binding]; other site
224914005885	glutamase interaction surface [polypeptide binding]; other site
224914005886	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
224914005887	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
224914005888	catalytic residues [active]
224914005889	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
224914005890	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
224914005891	putative active site [active]
224914005892	oxyanion strand; other site
224914005893	catalytic triad [active]
224914005894	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
224914005895	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
224914005896	putative active site pocket [active]
224914005897	4-fold oligomerization interface [polypeptide binding]; other site
224914005898	metal binding residues [ion binding]; metal-binding site
224914005899	3-fold/trimer interface [polypeptide binding]; other site
224914005900	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
224914005901	active site
224914005902	HslU subunit interaction site [polypeptide binding]; other site
224914005903	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
224914005904	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914005905	Walker A motif; other site
224914005906	ATP binding site [chemical binding]; other site
224914005907	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005908	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
224914005909	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
224914005910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224914005911	sequence-specific DNA binding site [nucleotide binding]; other site
224914005912	salt bridge; other site
224914005913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
224914005914	Smr domain; Region: Smr; cl02619
224914005915	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
224914005916	MltA specific insert domain; Region: MltA; cl08398
224914005917	3D domain; Region: 3D; cl01439
224914005918	Tim44-like domain; Region: Tim44; cl09208
224914005919	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
224914005920	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
224914005921	SecA binding site; other site
224914005922	Preprotein binding site; other site
224914005923	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
224914005924	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
224914005925	active site
224914005926	substrate binding site [chemical binding]; other site
224914005927	catalytic site [active]
224914005928	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
224914005929	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
224914005930	CoA-binding site [chemical binding]; other site
224914005931	ATP-binding [chemical binding]; other site
224914005932	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
224914005933	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
224914005934	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
224914005935	shikimate binding site; other site
224914005936	NAD(P) binding site [chemical binding]; other site
224914005937	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
224914005938	active site
224914005939	dimer interface [polypeptide binding]; other site
224914005940	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
224914005941	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224914005942	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
224914005943	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914005944	Walker A/P-loop; other site
224914005945	ATP binding site [chemical binding]; other site
224914005946	Q-loop/lid; other site
224914005947	ABC transporter signature motif; other site
224914005948	Walker B; other site
224914005949	D-loop; other site
224914005950	H-loop/switch region; other site
224914005951	TOBE domain; Region: TOBE_2; cl01440
224914005952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914005953	dimer interface [polypeptide binding]; other site
224914005954	conserved gate region; other site
224914005955	putative PBP binding loops; other site
224914005956	ABC-ATPase subunit interface; other site
224914005957	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914005958	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
224914005959	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
224914005960	active site residue [active]
224914005961	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
224914005962	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
224914005963	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
224914005964	active site
224914005965	intersubunit interface [polypeptide binding]; other site
224914005966	catalytic residue [active]
224914005967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
224914005968	Peptidase M15; Region: Peptidase_M15_3; cl01194
224914005969	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
224914005970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914005971	active site
224914005972	phosphorylation site [posttranslational modification]
224914005973	intermolecular recognition site; other site
224914005974	dimerization interface [polypeptide binding]; other site
224914005975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914005976	Walker A motif; other site
224914005977	ATP binding site [chemical binding]; other site
224914005978	Walker B motif; other site
224914005979	Helix-turn-helix domains; Region: HTH; cl00088
224914005980	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
224914005981	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
224914005982	active site
224914005983	Zn binding site [ion binding]; other site
224914005984	aminodeoxychorismate synthase; Provisional; Region: PRK07508
224914005985	chorismate binding enzyme; Region: Chorismate_bind; cl10555
224914005986	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
224914005987	Aminotransferase class IV; Region: Aminotran_4; pfam01063
224914005988	substrate-cofactor binding pocket; other site
224914005989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914005990	homodimer interface [polypeptide binding]; other site
224914005991	catalytic residue [active]
224914005992	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
224914005993	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
224914005994	ferrochelatase; Reviewed; Region: hemH; PRK00035
224914005995	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
224914005996	C-terminal domain interface [polypeptide binding]; other site
224914005997	active site
224914005998	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
224914005999	active site
224914006000	N-terminal domain interface [polypeptide binding]; other site
224914006001	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
224914006002	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
224914006003	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
224914006004	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
224914006005	putative active site [active]
224914006006	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
224914006007	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051
224914006008	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
224914006009	active site
224914006010	tetramer interface; other site
224914006011	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
224914006012	lytic murein transglycosylase; Region: MltB_2; TIGR02283
224914006013	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
224914006014	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
224914006015	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224914006016	catalytic residue [active]
224914006017	TrbC/VIRB2 family; Region: TrbC; cl01583
224914006018	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
224914006019	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
224914006020	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
224914006021	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
224914006022	Type IV secretion system proteins; Region: T4SS; pfam07996
224914006023	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
224914006024	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
224914006025	VirB8 protein; Region: VirB8; cl01500
224914006026	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
224914006027	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
224914006028	VirB7 interaction site; other site
224914006029	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
224914006030	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
224914006031	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
224914006032	Walker A motif; other site
224914006033	hexamer interface [polypeptide binding]; other site
224914006034	ATP binding site [chemical binding]; other site
224914006035	Walker B motif; other site
224914006036	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224914006037	ligand binding site [chemical binding]; other site
224914006038	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
224914006039	active site
224914006040	catalytic triad [active]
224914006041	oxyanion hole [active]
224914006042	Amino acid permease; Region: AA_permease; cl00524
224914006043	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
224914006044	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
224914006045	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
224914006046	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
224914006047	active site
224914006048	dimer interface [polypeptide binding]; other site
224914006049	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
224914006050	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
224914006051	active site
224914006052	FMN binding site [chemical binding]; other site
224914006053	substrate binding site [chemical binding]; other site
224914006054	3Fe-4S cluster binding site [ion binding]; other site
224914006055	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
224914006056	domain interface; other site
224914006057	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
224914006058	tetramer interface [polypeptide binding]; other site
224914006059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914006060	catalytic residue [active]
224914006061	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
224914006062	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
224914006063	putative dimer interface [polypeptide binding]; other site
224914006064	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
224914006065	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
224914006066	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914006067	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
224914006068	active site
224914006069	N-formylglutamate amidohydrolase; Region: FGase; cl01522
224914006070	Response regulator receiver domain; Region: Response_reg; pfam00072
224914006071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914006072	active site
224914006073	phosphorylation site [posttranslational modification]
224914006074	intermolecular recognition site; other site
224914006075	dimerization interface [polypeptide binding]; other site
224914006076	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
224914006077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914006078	active site
224914006079	phosphorylation site [posttranslational modification]
224914006080	intermolecular recognition site; other site
224914006081	dimerization interface [polypeptide binding]; other site
224914006082	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224914006083	dimerization interface [polypeptide binding]; other site
224914006084	DNA binding residues [nucleotide binding]
224914006085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914006086	dimer interface [polypeptide binding]; other site
224914006087	phosphorylation site [posttranslational modification]
224914006088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914006089	ATP binding site [chemical binding]; other site
224914006090	Mg2+ binding site [ion binding]; other site
224914006091	G-X-G motif; other site
224914006092	MgtC family; Region: MgtC; cl12207
224914006093	magnesium-transporting ATPase; Provisional; Region: PRK15122
224914006094	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
224914006095	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224914006096	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914006097	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
224914006098	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
224914006099	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
224914006100	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
224914006101	shikimate binding site; other site
224914006102	NAD(P) binding site [chemical binding]; other site
224914006103	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
224914006104	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224914006105	E3 interaction surface; other site
224914006106	lipoyl attachment site [posttranslational modification]; other site
224914006107	e3 binding domain; Region: E3_binding; pfam02817
224914006108	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
224914006109	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
224914006110	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
224914006111	tetramer interface [polypeptide binding]; other site
224914006112	TPP-binding site [chemical binding]; other site
224914006113	heterodimer interface [polypeptide binding]; other site
224914006114	phosphorylation loop region [posttranslational modification]
224914006115	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
224914006116	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
224914006117	alpha subunit interface [polypeptide binding]; other site
224914006118	TPP binding site [chemical binding]; other site
224914006119	heterodimer interface [polypeptide binding]; other site
224914006120	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224914006121	classical (c) SDRs; Region: SDR_c; cd05233
224914006122	NAD(P) binding site [chemical binding]; other site
224914006123	active site
224914006124	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224914006125	classical (c) SDRs; Region: SDR_c; cd05233
224914006126	NAD(P) binding site [chemical binding]; other site
224914006127	active site
224914006128	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
224914006129	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914006130	active site
224914006131	metal binding site [ion binding]; metal-binding site
224914006132	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
224914006133	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
224914006134	Walker A/P-loop; other site
224914006135	ATP binding site [chemical binding]; other site
224914006136	Q-loop/lid; other site
224914006137	ABC transporter signature motif; other site
224914006138	Walker B; other site
224914006139	D-loop; other site
224914006140	H-loop/switch region; other site
224914006141	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
224914006142	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
224914006143	Walker A/P-loop; other site
224914006144	ATP binding site [chemical binding]; other site
224914006145	Q-loop/lid; other site
224914006146	ABC transporter signature motif; other site
224914006147	Walker B; other site
224914006148	D-loop; other site
224914006149	H-loop/switch region; other site
224914006150	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
224914006151	TM-ABC transporter signature motif; other site
224914006152	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
224914006153	TM-ABC transporter signature motif; other site
224914006154	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914006155	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914006156	Transcriptional regulators [Transcription]; Region: FadR; COG2186
224914006157	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914006158	DNA-binding site [nucleotide binding]; DNA binding site
224914006159	FCD domain; Region: FCD; cl11656
224914006160	RNA polymerase sigma factor; Provisional; Region: PRK12539
224914006161	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224914006162	Protein of unknown function (DUF1109); Region: DUF1109; cl02071
224914006163	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
224914006164	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
224914006165	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
224914006166	Moco binding site; other site
224914006167	metal coordination site [ion binding]; other site
224914006168	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
224914006169	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
224914006170	chorismate binding enzyme; Region: Chorismate_bind; cl10555
224914006171	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
224914006172	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
224914006173	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
224914006174	hydrophobic substrate binding pocket; other site
224914006175	Isochorismatase family; Region: Isochorismatase; pfam00857
224914006176	active site
224914006177	conserved cis-peptide bond; other site
224914006178	Phosphopantetheine attachment site; Region: PP-binding; cl09936
224914006179	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224914006180	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
224914006181	putative NAD(P) binding site [chemical binding]; other site
224914006182	active site
224914006183	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
224914006184	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
224914006185	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
224914006186	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914006187	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914006188	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
224914006189	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
224914006190	Walker A/P-loop; other site
224914006191	ATP binding site [chemical binding]; other site
224914006192	Q-loop/lid; other site
224914006193	ABC transporter signature motif; other site
224914006194	Walker B; other site
224914006195	D-loop; other site
224914006196	H-loop/switch region; other site
224914006197	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
224914006198	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
224914006199	TM-ABC transporter signature motif; other site
224914006200	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
224914006201	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
224914006202	TM-ABC transporter signature motif; other site
224914006203	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
224914006204	active site
224914006205	tetramer interface [polypeptide binding]; other site
224914006206	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224914006207	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
224914006208	substrate binding site [chemical binding]; other site
224914006209	dimer interface [polypeptide binding]; other site
224914006210	ATP binding site [chemical binding]; other site
224914006211	replication initiation protein RepC; Provisional; Region: PRK13824
224914006212	Replication protein C N-terminal domain; Region: RP-C; pfam03428
224914006213	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
224914006214	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
224914006215	ParB-like nuclease domain; Region: ParBc; cl02129
224914006216	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
224914006217	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
224914006218	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
224914006219	P-loop; other site
224914006220	Magnesium ion binding site [ion binding]; other site
224914006221	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
224914006222	P-loop; other site
224914006223	Magnesium ion binding site [ion binding]; other site
224914006224	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
224914006225	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914006226	FeS/SAM binding site; other site
224914006227	HemN C-terminal region; Region: HemN_C; pfam06969
224914006228	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
224914006229	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224914006230	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914006231	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
224914006232	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
224914006233	Walker A/P-loop; other site
224914006234	ATP binding site [chemical binding]; other site
224914006235	Q-loop/lid; other site
224914006236	ABC transporter signature motif; other site
224914006237	Walker B; other site
224914006238	D-loop; other site
224914006239	H-loop/switch region; other site
224914006240	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914006241	Q-loop/lid; other site
224914006242	ABC transporter signature motif; other site
224914006243	Walker B; other site
224914006244	D-loop; other site
224914006245	H-loop/switch region; other site
224914006246	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914006247	spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187
224914006248	Walker A/P-loop; other site
224914006249	ATP binding site [chemical binding]; other site
224914006250	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
224914006251	TM-ABC transporter signature motif; other site
224914006252	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
224914006253	TM-ABC transporter signature motif; other site
224914006254	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
224914006255	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
224914006256	putative ligand binding site [chemical binding]; other site
224914006257	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224914006258	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914006259	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
224914006260	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
224914006261	N-terminal plug; other site
224914006262	ligand-binding site [chemical binding]; other site
224914006263	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
224914006264	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
224914006265	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
224914006266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006267	dimer interface [polypeptide binding]; other site
224914006268	conserved gate region; other site
224914006269	putative PBP binding loops; other site
224914006270	ABC-ATPase subunit interface; other site
224914006271	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
224914006272	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
224914006273	Walker A/P-loop; other site
224914006274	ATP binding site [chemical binding]; other site
224914006275	Q-loop/lid; other site
224914006276	ABC transporter signature motif; other site
224914006277	Walker B; other site
224914006278	D-loop; other site
224914006279	H-loop/switch region; other site
224914006280	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
224914006281	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
224914006282	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
224914006283	Sulfatase; Region: Sulfatase; cl10460
224914006284	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224914006285	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
224914006286	active site
224914006287	metal binding site [ion binding]; metal-binding site
224914006288	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
224914006289	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914006290	Walker A/P-loop; other site
224914006291	ATP binding site [chemical binding]; other site
224914006292	Q-loop/lid; other site
224914006293	ABC transporter signature motif; other site
224914006294	Walker B; other site
224914006295	D-loop; other site
224914006296	H-loop/switch region; other site
224914006297	TOBE domain; Region: TOBE_2; cl01440
224914006298	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
224914006299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914006300	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224914006301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006302	dimer interface [polypeptide binding]; other site
224914006303	conserved gate region; other site
224914006304	putative PBP binding loops; other site
224914006305	ABC-ATPase subunit interface; other site
224914006306	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224914006307	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914006308	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
224914006309	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914006310	DNA-binding site [nucleotide binding]; DNA binding site
224914006311	UTRA domain; Region: UTRA; cl01230
224914006312	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
224914006313	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
224914006314	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
224914006315	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
224914006316	Walker A/P-loop; other site
224914006317	ATP binding site [chemical binding]; other site
224914006318	Q-loop/lid; other site
224914006319	ABC transporter signature motif; other site
224914006320	Walker B; other site
224914006321	D-loop; other site
224914006322	H-loop/switch region; other site
224914006323	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
224914006324	TM-ABC transporter signature motif; other site
224914006325	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
224914006326	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
224914006327	Walker A/P-loop; other site
224914006328	ATP binding site [chemical binding]; other site
224914006329	Q-loop/lid; other site
224914006330	ABC transporter signature motif; other site
224914006331	Walker B; other site
224914006332	D-loop; other site
224914006333	H-loop/switch region; other site
224914006334	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
224914006335	TM-ABC transporter signature motif; other site
224914006336	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
224914006337	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
224914006338	putative ligand binding site [chemical binding]; other site
224914006339	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
224914006340	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
224914006341	active site
224914006342	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914006343	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914006344	Amino acid permease; Region: AA_permease; cl00524
224914006345	Helix-turn-helix domains; Region: HTH; cl00088
224914006346	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224914006347	Bacterial transcriptional regulator; Region: IclR; pfam01614
224914006348	Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262
224914006349	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
224914006350	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914006351	motif II; other site
224914006352	hypothetical protein; Provisional; Region: PRK07481
224914006353	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224914006354	inhibitor-cofactor binding pocket; inhibition site
224914006355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914006356	catalytic residue [active]
224914006357	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
224914006358	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224914006359	inhibitor-cofactor binding pocket; inhibition site
224914006360	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914006361	catalytic residue [active]
224914006362	Phosphotransferase enzyme family; Region: APH; pfam01636
224914006363	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
224914006364	active site
224914006365	ATP binding site [chemical binding]; other site
224914006366	substrate binding site [chemical binding]; other site
224914006367	Helix-turn-helix domains; Region: HTH; cl00088
224914006368	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224914006369	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
224914006370	putative substrate binding pocket [chemical binding]; other site
224914006371	trimer interface [polypeptide binding]; other site
224914006372	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914006373	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
224914006374	NAD binding site [chemical binding]; other site
224914006375	catalytic residues [active]
224914006376	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
224914006377	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
224914006378	active site
224914006379	metal binding site [ion binding]; metal-binding site
224914006380	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
224914006381	tetramer interface [polypeptide binding]; other site
224914006382	active site
224914006383	metal binding site [ion binding]; metal-binding site
224914006384	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
224914006385	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
224914006386	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
224914006387	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
224914006388	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914006389	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914006390	NAD(P) binding site [chemical binding]; other site
224914006391	catalytic residues [active]
224914006392	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914006393	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
224914006394	Helix-turn-helix domains; Region: HTH; cl00088
224914006395	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914006396	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914006397	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914006398	TM-ABC transporter signature motif; other site
224914006399	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
224914006400	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
224914006401	Walker A/P-loop; other site
224914006402	ATP binding site [chemical binding]; other site
224914006403	Q-loop/lid; other site
224914006404	ABC transporter signature motif; other site
224914006405	Walker B; other site
224914006406	D-loop; other site
224914006407	H-loop/switch region; other site
224914006408	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
224914006409	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
224914006410	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
224914006411	putative ligand binding site [chemical binding]; other site
224914006412	Uncharacterized conserved protein [Function unknown]; Region: COG3268
224914006413	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
224914006414	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006415	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006416	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006417	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006418	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
224914006419	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006420	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006421	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006422	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
224914006423	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006424	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
224914006425	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
224914006426	Autotransporter beta-domain; Region: Autotransporter; cl02365
224914006427	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914006428	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
224914006429	flagellin; Reviewed; Region: PRK12687
224914006430	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
224914006431	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
224914006432	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
224914006433	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
224914006434	flagellar motor protein MotB; Validated; Region: motB; PRK05996
224914006435	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224914006436	ligand binding site [chemical binding]; other site
224914006437	chemotaxis protein; Reviewed; Region: PRK12798
224914006438	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
224914006439	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
224914006440	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
224914006441	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224914006442	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224914006443	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914006444	DNA binding site [nucleotide binding]
224914006445	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
224914006446	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
224914006447	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
224914006448	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
224914006449	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
224914006450	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
224914006451	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
224914006452	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
224914006453	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
224914006454	Flagellar protein FlaF; Region: FlaF; cl11454
224914006455	Flagellar protein FlbT; Region: FlbT; cl11455
224914006456	Flagellar hook capping protein; Region: FlgD; cl04347
224914006457	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
224914006458	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
224914006459	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
224914006460	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
224914006461	Rod binding protein; Region: Rod-binding; cl01626
224914006462	FlgN protein; Region: FlgN; cl09176
224914006463	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224914006464	metal binding site 2 [ion binding]; metal-binding site
224914006465	putative DNA binding helix; other site
224914006466	metal binding site 1 [ion binding]; metal-binding site
224914006467	dimer interface [polypeptide binding]; other site
224914006468	structural Zn2+ binding site [ion binding]; other site
224914006469	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224914006470	ABC-ATPase subunit  interface; other site
224914006471	dimer interface [polypeptide binding]; other site
224914006472	putative PBP binding regions; other site
224914006473	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
224914006474	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
224914006475	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
224914006476	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
224914006477	metal binding site [ion binding]; metal-binding site
224914006478	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
224914006479	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914006480	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
224914006481	Rrf2 family protein; Region: rrf2_super; TIGR00738
224914006482	Helix-turn-helix domains; Region: HTH; cl00088
224914006483	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
224914006484	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
224914006485	putative transposase OrfB; Reviewed; Region: PHA02517
224914006486	Integrase core domain; Region: rve; cl01316
224914006487	Helix-turn-helix domains; Region: HTH; cl00088
224914006488	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
224914006489	PemK-like protein; Region: PemK; cl00995
224914006490	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
224914006491	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
224914006492	intersubunit interface [polypeptide binding]; other site
224914006493	active site
224914006494	Zn2+ binding site [ion binding]; other site
224914006495	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
224914006496	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914006497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914006498	catalytic residue [active]
224914006499	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
224914006500	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914006501	Walker A/P-loop; other site
224914006502	ATP binding site [chemical binding]; other site
224914006503	Q-loop/lid; other site
224914006504	ABC transporter signature motif; other site
224914006505	Walker B; other site
224914006506	D-loop; other site
224914006507	H-loop/switch region; other site
224914006508	TOBE domain; Region: TOBE_2; cl01440
224914006509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006510	dimer interface [polypeptide binding]; other site
224914006511	conserved gate region; other site
224914006512	putative PBP binding loops; other site
224914006513	ABC-ATPase subunit interface; other site
224914006514	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
224914006515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006516	dimer interface [polypeptide binding]; other site
224914006517	conserved gate region; other site
224914006518	putative PBP binding loops; other site
224914006519	ABC-ATPase subunit interface; other site
224914006520	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914006521	amidase; Provisional; Region: PRK07486
224914006522	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
224914006523	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
224914006524	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224914006525	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914006526	Walker A/P-loop; other site
224914006527	ATP binding site [chemical binding]; other site
224914006528	Q-loop/lid; other site
224914006529	ABC transporter signature motif; other site
224914006530	Walker B; other site
224914006531	D-loop; other site
224914006532	H-loop/switch region; other site
224914006533	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914006534	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224914006535	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914006536	Walker A/P-loop; other site
224914006537	ATP binding site [chemical binding]; other site
224914006538	Q-loop/lid; other site
224914006539	ABC transporter signature motif; other site
224914006540	Walker B; other site
224914006541	D-loop; other site
224914006542	H-loop/switch region; other site
224914006543	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914006544	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
224914006545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006546	dimer interface [polypeptide binding]; other site
224914006547	conserved gate region; other site
224914006548	putative PBP binding loops; other site
224914006549	ABC-ATPase subunit interface; other site
224914006550	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224914006551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006552	dimer interface [polypeptide binding]; other site
224914006553	conserved gate region; other site
224914006554	putative PBP binding loops; other site
224914006555	ABC-ATPase subunit interface; other site
224914006556	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
224914006557	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
224914006558	Helix-turn-helix domains; Region: HTH; cl00088
224914006559	FCD domain; Region: FCD; cl11656
224914006560	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
224914006561	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914006562	Walker A/P-loop; other site
224914006563	ATP binding site [chemical binding]; other site
224914006564	Q-loop/lid; other site
224914006565	ABC transporter signature motif; other site
224914006566	Walker B; other site
224914006567	D-loop; other site
224914006568	H-loop/switch region; other site
224914006569	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914006570	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224914006571	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914006572	Walker A/P-loop; other site
224914006573	ATP binding site [chemical binding]; other site
224914006574	Q-loop/lid; other site
224914006575	ABC transporter signature motif; other site
224914006576	Walker B; other site
224914006577	D-loop; other site
224914006578	H-loop/switch region; other site
224914006579	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914006580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006581	putative PBP binding loops; other site
224914006582	dimer interface [polypeptide binding]; other site
224914006583	ABC-ATPase subunit interface; other site
224914006584	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
224914006585	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224914006586	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006587	dimer interface [polypeptide binding]; other site
224914006588	conserved gate region; other site
224914006589	putative PBP binding loops; other site
224914006590	ABC-ATPase subunit interface; other site
224914006591	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
224914006592	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
224914006593	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
224914006594	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
224914006595	Penicillin amidase; Region: Penicil_amidase; pfam01804
224914006596	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
224914006597	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
224914006598	active site
224914006599	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224914006600	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
224914006601	active site
224914006602	enoyl-CoA hydratase; Provisional; Region: PRK08138
224914006603	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914006604	substrate binding site [chemical binding]; other site
224914006605	oxyanion hole (OAH) forming residues; other site
224914006606	trimer interface [polypeptide binding]; other site
224914006607	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
224914006608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914006609	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224914006610	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224914006611	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
224914006612	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
224914006613	tetramer interface [polypeptide binding]; other site
224914006614	TPP-binding site [chemical binding]; other site
224914006615	heterodimer interface [polypeptide binding]; other site
224914006616	phosphorylation loop region [posttranslational modification]
224914006617	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
224914006618	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
224914006619	alpha subunit interface [polypeptide binding]; other site
224914006620	TPP binding site [chemical binding]; other site
224914006621	heterodimer interface [polypeptide binding]; other site
224914006622	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224914006623	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
224914006624	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
224914006625	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
224914006626	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224914006627	E3 interaction surface; other site
224914006628	lipoyl attachment site [posttranslational modification]; other site
224914006629	e3 binding domain; Region: E3_binding; pfam02817
224914006630	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914006631	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224914006632	Helix-turn-helix domains; Region: HTH; cl00088
224914006633	Bacterial transcriptional regulator; Region: IclR; pfam01614
224914006634	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224914006635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006636	dimer interface [polypeptide binding]; other site
224914006637	conserved gate region; other site
224914006638	putative PBP binding loops; other site
224914006639	ABC-ATPase subunit interface; other site
224914006640	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
224914006641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914006642	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224914006643	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914006644	Walker A/P-loop; other site
224914006645	ATP binding site [chemical binding]; other site
224914006646	Q-loop/lid; other site
224914006647	ABC transporter signature motif; other site
224914006648	Walker B; other site
224914006649	D-loop; other site
224914006650	H-loop/switch region; other site
224914006651	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914006652	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
224914006653	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914006654	Walker A/P-loop; other site
224914006655	ATP binding site [chemical binding]; other site
224914006656	Q-loop/lid; other site
224914006657	ABC transporter signature motif; other site
224914006658	Walker B; other site
224914006659	D-loop; other site
224914006660	H-loop/switch region; other site
224914006661	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914006662	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
224914006663	CoA-transferase family III; Region: CoA_transf_3; pfam02515
224914006664	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914006665	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
224914006666	tetramerization interface [polypeptide binding]; other site
224914006667	NAD(P) binding site [chemical binding]; other site
224914006668	catalytic residues [active]
224914006669	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914006670	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914006671	DNA-binding site [nucleotide binding]; DNA binding site
224914006672	FCD domain; Region: FCD; cl11656
224914006673	Helix-turn-helix domains; Region: HTH; cl00088
224914006674	putative transposase OrfB; Reviewed; Region: PHA02517
224914006675	Integrase core domain; Region: rve; cl01316
224914006676	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
224914006677	SlyX; Region: SlyX; cl01090
224914006678	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
224914006679	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
224914006680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914006681	S-adenosylmethionine binding site [chemical binding]; other site
224914006682	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
224914006683	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
224914006684	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
224914006685	active site
224914006686	ATP binding site [chemical binding]; other site
224914006687	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
224914006688	Flavoprotein; Region: Flavoprotein; cl08021
224914006689	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
224914006690	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
224914006691	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
224914006692	G1 box; other site
224914006693	putative GEF interaction site [polypeptide binding]; other site
224914006694	GTP/Mg2+ binding site [chemical binding]; other site
224914006695	Switch I region; other site
224914006696	G2 box; other site
224914006697	G3 box; other site
224914006698	Switch II region; other site
224914006699	G4 box; other site
224914006700	G5 box; other site
224914006701	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
224914006702	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
224914006703	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
224914006704	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
224914006705	putative active site [active]
224914006706	catalytic site [active]
224914006707	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
224914006708	putative active site [active]
224914006709	catalytic site [active]
224914006710	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
224914006711	putative catalytic site [active]
224914006712	putative metal binding site [ion binding]; other site
224914006713	putative phosphate binding site [ion binding]; other site
224914006714	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914006715	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
224914006716	NAD(P) binding site [chemical binding]; other site
224914006717	catalytic residues [active]
224914006718	YhhN-like protein; Region: YhhN; cl01505
224914006719	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224914006720	Ligand Binding Site [chemical binding]; other site
224914006721	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
224914006722	putative FMN binding site [chemical binding]; other site
224914006723	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
224914006724	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
224914006725	active site
224914006726	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224914006727	catalytic core [active]
224914006728	dihydrodipicolinate reductase; Provisional; Region: PRK00048
224914006729	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914006730	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
224914006731	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224914006732	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914006733	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
224914006734	Walker A/P-loop; other site
224914006735	ATP binding site [chemical binding]; other site
224914006736	Q-loop/lid; other site
224914006737	ABC transporter signature motif; other site
224914006738	Walker B; other site
224914006739	D-loop; other site
224914006740	H-loop/switch region; other site
224914006741	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
224914006742	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
224914006743	active site
224914006744	dimer interfaces [polypeptide binding]; other site
224914006745	catalytic residues [active]
224914006746	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
224914006747	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
224914006748	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
224914006749	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
224914006750	putative NAD(P) binding site [chemical binding]; other site
224914006751	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
224914006752	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
224914006753	HEAT repeat; Region: HEAT; pfam02985
224914006754	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
224914006755	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
224914006756	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
224914006757	N-terminal domain interface [polypeptide binding]; other site
224914006758	dimer interface [polypeptide binding]; other site
224914006759	substrate binding pocket (H-site) [chemical binding]; other site
224914006760	Bacitracin resistance protein BacA; Region: BacA; cl00858
224914006761	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
224914006762	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
224914006763	putative NAD(P) binding site [chemical binding]; other site
224914006764	active site
224914006765	GTP-binding protein LepA; Provisional; Region: PRK05433
224914006766	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
224914006767	G1 box; other site
224914006768	putative GEF interaction site [polypeptide binding]; other site
224914006769	GTP/Mg2+ binding site [chemical binding]; other site
224914006770	Switch I region; other site
224914006771	G2 box; other site
224914006772	G3 box; other site
224914006773	Switch II region; other site
224914006774	G4 box; other site
224914006775	G5 box; other site
224914006776	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
224914006777	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
224914006778	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
224914006779	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
224914006780	GIY-YIG motif/motif A; other site
224914006781	putative active site [active]
224914006782	putative metal binding site [ion binding]; other site
224914006783	Rdx family; Region: Rdx; cl01407
224914006784	RmuC family; Region: RmuC; pfam02646
224914006785	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
224914006786	active site
224914006787	catalytic residues [active]
224914006788	metal binding site [ion binding]; metal-binding site
224914006789	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
224914006790	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
224914006791	putative active site [active]
224914006792	substrate binding site [chemical binding]; other site
224914006793	putative cosubstrate binding site; other site
224914006794	catalytic site [active]
224914006795	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
224914006796	substrate binding site [chemical binding]; other site
224914006797	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
224914006798	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
224914006799	dimerization interface 3.5A [polypeptide binding]; other site
224914006800	active site
224914006801	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
224914006802	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
224914006803	metal binding site [ion binding]; metal-binding site
224914006804	dimer interface [polypeptide binding]; other site
224914006805	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
224914006806	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
224914006807	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
224914006808	trimer interface [polypeptide binding]; other site
224914006809	active site
224914006810	substrate binding site [chemical binding]; other site
224914006811	CoA binding site [chemical binding]; other site
224914006812	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
224914006813	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914006814	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
224914006815	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
224914006816	feedback inhibition sensing region; other site
224914006817	homohexameric interface [polypeptide binding]; other site
224914006818	nucleotide binding site [chemical binding]; other site
224914006819	N-acetyl-L-glutamate binding site [chemical binding]; other site
224914006820	Predicted GTPase [General function prediction only]; Region: COG0218
224914006821	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
224914006822	G1 box; other site
224914006823	GTP/Mg2+ binding site [chemical binding]; other site
224914006824	Switch I region; other site
224914006825	G2 box; other site
224914006826	G3 box; other site
224914006827	Switch II region; other site
224914006828	G4 box; other site
224914006829	G5 box; other site
224914006830	membrane protein insertase; Provisional; Region: PRK01318
224914006831	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
224914006832	Ribonuclease P; Region: Ribonuclease_P; cl00457
224914006833	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
224914006834	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
224914006835	homotrimer interaction site [polypeptide binding]; other site
224914006836	putative active site [active]
224914006837	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
224914006838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914006839	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224914006840	putative substrate translocation pore; other site
224914006841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914006842	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914006843	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914006844	DNA-binding site [nucleotide binding]; DNA binding site
224914006845	FCD domain; Region: FCD; cl11656
224914006846	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914006847	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
224914006848	NAD(P) binding site [chemical binding]; other site
224914006849	catalytic residues [active]
224914006850	catalytic residues [active]
224914006851	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
224914006852	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
224914006853	putative NAD(P) binding site [chemical binding]; other site
224914006854	active site
224914006855	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
224914006856	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
224914006857	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224914006858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006859	dimer interface [polypeptide binding]; other site
224914006860	conserved gate region; other site
224914006861	putative PBP binding loops; other site
224914006862	ABC-ATPase subunit interface; other site
224914006863	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
224914006864	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
224914006865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914006866	dimer interface [polypeptide binding]; other site
224914006867	conserved gate region; other site
224914006868	putative PBP binding loops; other site
224914006869	ABC-ATPase subunit interface; other site
224914006870	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224914006871	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914006872	Walker A/P-loop; other site
224914006873	ATP binding site [chemical binding]; other site
224914006874	Q-loop/lid; other site
224914006875	ABC transporter signature motif; other site
224914006876	Walker B; other site
224914006877	D-loop; other site
224914006878	H-loop/switch region; other site
224914006879	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914006880	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
224914006881	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914006882	Walker A/P-loop; other site
224914006883	ATP binding site [chemical binding]; other site
224914006884	Q-loop/lid; other site
224914006885	ABC transporter signature motif; other site
224914006886	Walker B; other site
224914006887	D-loop; other site
224914006888	H-loop/switch region; other site
224914006889	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914006890	amidase; Provisional; Region: PRK07042
224914006891	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
224914006892	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
224914006893	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
224914006894	active site
224914006895	substrate binding site [chemical binding]; other site
224914006896	catalytic site [active]
224914006897	Predicted dehydrogenase [General function prediction only]; Region: COG0579
224914006898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914006899	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914006900	metal binding site [ion binding]; metal-binding site
224914006901	active site
224914006902	I-site; other site
224914006903	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
224914006904	glutathionine S-transferase; Provisional; Region: PRK10542
224914006905	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
224914006906	C-terminal domain interface [polypeptide binding]; other site
224914006907	GSH binding site (G-site) [chemical binding]; other site
224914006908	dimer interface [polypeptide binding]; other site
224914006909	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
224914006910	dimer interface [polypeptide binding]; other site
224914006911	N-terminal domain interface [polypeptide binding]; other site
224914006912	substrate binding pocket (H-site) [chemical binding]; other site
224914006913	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
224914006914	dimer interface [polypeptide binding]; other site
224914006915	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914006916	metal binding site [ion binding]; metal-binding site
224914006917	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
224914006918	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
224914006919	N-terminal plug; other site
224914006920	ligand-binding site [chemical binding]; other site
224914006921	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224914006922	Helix-turn-helix domains; Region: HTH; cl00088
224914006923	Bacterial transcriptional regulator; Region: IclR; pfam01614
224914006924	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914006925	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
224914006926	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
224914006927	Walker A/P-loop; other site
224914006928	ATP binding site [chemical binding]; other site
224914006929	Q-loop/lid; other site
224914006930	ABC transporter signature motif; other site
224914006931	Walker B; other site
224914006932	D-loop; other site
224914006933	H-loop/switch region; other site
224914006934	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
224914006935	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914006936	TM-ABC transporter signature motif; other site
224914006937	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914006938	TM-ABC transporter signature motif; other site
224914006939	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
224914006940	homotrimer interaction site [polypeptide binding]; other site
224914006941	putative active site [active]
224914006942	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
224914006943	TMAO/DMSO reductase; Reviewed; Region: PRK05363
224914006944	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
224914006945	Moco binding site; other site
224914006946	metal coordination site [ion binding]; other site
224914006947	Predicted esterase [General function prediction only]; Region: COG0400
224914006948	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
224914006949	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
224914006950	structural tetrad; other site
224914006951	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
224914006952	P-loop, Walker A motif; other site
224914006953	Base recognition motif; other site
224914006954	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
224914006955	Creatinine amidohydrolase; Region: Creatininase; cl00618
224914006956	Helix-turn-helix domains; Region: HTH; cl00088
224914006957	transcriptional regulator SlyA; Provisional; Region: PRK03573
224914006958	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224914006959	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224914006960	DNA binding site [nucleotide binding]
224914006961	domain linker motif; other site
224914006962	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
224914006963	putative dimerization interface [polypeptide binding]; other site
224914006964	putative ligand binding site [chemical binding]; other site
224914006965	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
224914006966	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914006967	Peptidase C26; Region: Peptidase_C26; pfam07722
224914006968	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
224914006969	catalytic triad [active]
224914006970	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
224914006971	classical (c) SDRs; Region: SDR_c; cd05233
224914006972	NAD(P) binding site [chemical binding]; other site
224914006973	active site
224914006974	PAS fold; Region: PAS_7; pfam12860
224914006975	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914006976	metal binding site [ion binding]; metal-binding site
224914006977	active site
224914006978	I-site; other site
224914006979	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224914006980	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
224914006981	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
224914006982	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
224914006983	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
224914006984	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
224914006985	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
224914006986	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
224914006987	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
224914006988	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
224914006989	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
224914006990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914006991	SAF domain; Region: SAF; cl00555
224914006992	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914006993	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
224914006994	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914006995	motif II; other site
224914006996	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
224914006997	putative active site [active]
224914006998	putative catalytic site [active]
224914006999	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
224914007000	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
224914007001	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224914007002	binding surface
224914007003	TPR motif; other site
224914007004	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224914007005	binding surface
224914007006	TPR motif; other site
224914007007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224914007008	binding surface
224914007009	TPR motif; other site
224914007010	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
224914007011	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914007012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007013	dimer interface [polypeptide binding]; other site
224914007014	conserved gate region; other site
224914007015	ABC-ATPase subunit interface; other site
224914007016	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
224914007017	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
224914007018	Walker A/P-loop; other site
224914007019	ATP binding site [chemical binding]; other site
224914007020	Q-loop/lid; other site
224914007021	ABC transporter signature motif; other site
224914007022	Walker B; other site
224914007023	D-loop; other site
224914007024	H-loop/switch region; other site
224914007025	NIL domain; Region: NIL; cl09633
224914007026	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
224914007027	choline dehydrogenase; Validated; Region: PRK02106
224914007028	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007029	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
224914007030	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
224914007031	TM-ABC transporter signature motif; other site
224914007032	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
224914007033	TM-ABC transporter signature motif; other site
224914007034	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
224914007035	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
224914007036	Walker A/P-loop; other site
224914007037	ATP binding site [chemical binding]; other site
224914007038	Q-loop/lid; other site
224914007039	ABC transporter signature motif; other site
224914007040	Walker B; other site
224914007041	D-loop; other site
224914007042	H-loop/switch region; other site
224914007043	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
224914007044	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
224914007045	Walker A/P-loop; other site
224914007046	ATP binding site [chemical binding]; other site
224914007047	Q-loop/lid; other site
224914007048	ABC transporter signature motif; other site
224914007049	Walker B; other site
224914007050	D-loop; other site
224914007051	H-loop/switch region; other site
224914007052	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
224914007053	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
224914007054	putative ligand binding site [chemical binding]; other site
224914007055	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914007056	Helix-turn-helix domains; Region: HTH; cl00088
224914007057	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007058	dimerization interface [polypeptide binding]; other site
224914007059	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224914007060	Helix-turn-helix domains; Region: HTH; cl00088
224914007061	hypothetical protein; Provisional; Region: PRK06148
224914007062	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
224914007063	active site
224914007064	substrate binding site [chemical binding]; other site
224914007065	ATP binding site [chemical binding]; other site
224914007066	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
224914007067	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224914007068	inhibitor-cofactor binding pocket; inhibition site
224914007069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914007070	catalytic residue [active]
224914007071	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
224914007072	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224914007073	substrate binding pocket [chemical binding]; other site
224914007074	membrane-bound complex binding site; other site
224914007075	hinge residues; other site
224914007076	D-aminopeptidase; Reviewed; Region: PRK13128
224914007077	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
224914007078	D-aminopeptidase, domain B; Region: DAP_B; pfam07930
224914007079	D-aminopeptidase, domain C; Region: DAP_C; pfam07932
224914007080	thiamine pyrophosphate protein; Validated; Region: PRK08199
224914007081	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
224914007082	PYR/PP interface [polypeptide binding]; other site
224914007083	dimer interface [polypeptide binding]; other site
224914007084	TPP binding site [chemical binding]; other site
224914007085	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
224914007086	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
224914007087	TPP-binding site [chemical binding]; other site
224914007088	Transcriptional regulators [Transcription]; Region: FadR; COG2186
224914007089	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914007090	DNA-binding site [nucleotide binding]; DNA binding site
224914007091	FCD domain; Region: FCD; cl11656
224914007092	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
224914007093	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
224914007094	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914007095	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007096	Dehydratase family; Region: ILVD_EDD; cl00340
224914007097	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
224914007098	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
224914007099	Entner-Doudoroff aldolase; Region: eda; TIGR01182
224914007100	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
224914007101	active site
224914007102	intersubunit interface [polypeptide binding]; other site
224914007103	catalytic residue [active]
224914007104	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914007105	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
224914007106	putative ligand binding site [chemical binding]; other site
224914007107	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
224914007108	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
224914007109	Walker A/P-loop; other site
224914007110	ATP binding site [chemical binding]; other site
224914007111	Q-loop/lid; other site
224914007112	ABC transporter signature motif; other site
224914007113	Walker B; other site
224914007114	D-loop; other site
224914007115	H-loop/switch region; other site
224914007116	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
224914007117	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914007118	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914007119	TM-ABC transporter signature motif; other site
224914007120	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
224914007121	homodimer interface [polypeptide binding]; other site
224914007122	substrate-cofactor binding pocket; other site
224914007123	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914007124	Aminotransferase class IV; Region: Aminotran_4; pfam01063
224914007125	catalytic residue [active]
224914007126	HutD; Region: HutD; cl01532
224914007127	urocanate hydratase; Provisional; Region: PRK05414
224914007128	N-formylglutamate amidohydrolase; Region: FGase; cl01522
224914007129	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
224914007130	tetramer interface [polypeptide binding]; other site
224914007131	imidazolonepropionase; Validated; Region: PRK09356
224914007132	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
224914007133	active site
224914007134	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
224914007135	active sites [active]
224914007136	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
224914007137	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
224914007138	active site
224914007139	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
224914007140	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914007141	DNA-binding site [nucleotide binding]; DNA binding site
224914007142	UTRA domain; Region: UTRA; cl01230
224914007143	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
224914007144	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224914007145	inhibitor-cofactor binding pocket; inhibition site
224914007146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914007147	catalytic residue [active]
224914007148	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
224914007149	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224914007150	non-specific DNA binding site [nucleotide binding]; other site
224914007151	salt bridge; other site
224914007152	sequence-specific DNA binding site [nucleotide binding]; other site
224914007153	Cupin domain; Region: Cupin_2; cl09118
224914007154	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224914007155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007156	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
224914007157	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
224914007158	active site
224914007159	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224914007160	dimer interface [polypeptide binding]; other site
224914007161	substrate binding site [chemical binding]; other site
224914007162	catalytic residues [active]
224914007163	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224914007164	Helix-turn-helix domains; Region: HTH; cl00088
224914007165	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
224914007166	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
224914007167	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
224914007168	phosphate binding site [ion binding]; other site
224914007169	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
224914007170	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
224914007171	putative molybdopterin cofactor binding site [chemical binding]; other site
224914007172	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
224914007173	putative molybdopterin cofactor binding site; other site
224914007174	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224914007175	putative membrane fusion protein; Region: TIGR02828
224914007176	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224914007177	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
224914007178	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
224914007179	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914007180	DNA-binding site [nucleotide binding]; DNA binding site
224914007181	UTRA domain; Region: UTRA; cl01230
224914007182	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
224914007183	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
224914007184	dimer interface [polypeptide binding]; other site
224914007185	active site
224914007186	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
224914007187	dimer interface [polypeptide binding]; other site
224914007188	active site
224914007189	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
224914007190	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
224914007191	active site
224914007192	dimer interface [polypeptide binding]; other site
224914007193	hypothetical protein; Provisional; Region: PRK02947
224914007194	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
224914007195	putative active site [active]
224914007196	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
224914007197	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
224914007198	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
224914007199	putative active site [active]
224914007200	putative substrate binding site [chemical binding]; other site
224914007201	putative cosubstrate binding site; other site
224914007202	catalytic site [active]
224914007203	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
224914007204	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914007205	tetrameric interface [polypeptide binding]; other site
224914007206	NAD binding site [chemical binding]; other site
224914007207	catalytic residues [active]
224914007208	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
224914007209	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
224914007210	Helix-turn-helix domains; Region: HTH; cl00088
224914007211	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007212	dimerization interface [polypeptide binding]; other site
224914007213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007214	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224914007215	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
224914007216	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
224914007217	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
224914007218	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
224914007219	RNA binding site [nucleotide binding]; other site
224914007220	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914007221	dimerization interface [polypeptide binding]; other site
224914007222	putative DNA binding site [nucleotide binding]; other site
224914007223	putative Zn2+ binding site [ion binding]; other site
224914007224	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
224914007225	FMN binding site [chemical binding]; other site
224914007226	active site
224914007227	substrate binding site [chemical binding]; other site
224914007228	catalytic residue [active]
224914007229	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224914007230	Helix-turn-helix domains; Region: HTH; cl00088
224914007231	Arginase family; Region: Arginase; cl00306
224914007232	ornithine cyclodeaminase; Validated; Region: PRK07589
224914007233	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007234	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
224914007235	apolar tunnel; other site
224914007236	heme binding site [chemical binding]; other site
224914007237	dimerization interface [polypeptide binding]; other site
224914007238	Uncharacterized conserved protein [Function unknown]; Region: COG3760
224914007239	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
224914007240	putative deacylase active site [active]
224914007241	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
224914007242	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224914007243	catalytic residues [active]
224914007244	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
224914007245	Trm112p-like protein; Region: Trm112p; cl01066
224914007246	tartrate dehydrogenase; Provisional; Region: PRK08194
224914007247	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
224914007248	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
224914007249	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
224914007250	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
224914007251	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
224914007252	DNA binding site [nucleotide binding]
224914007253	active site
224914007254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914007255	putative substrate translocation pore; other site
224914007256	metabolite-proton symporter; Region: 2A0106; TIGR00883
224914007257	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
224914007258	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007259	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
224914007260	Transcriptional regulators [Transcription]; Region: MarR; COG1846
224914007261	Helix-turn-helix domains; Region: HTH; cl00088
224914007262	OsmC-like protein; Region: OsmC; cl00767
224914007263	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
224914007264	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
224914007265	substrate binding site [chemical binding]; other site
224914007266	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
224914007267	Domain of unknown function (DUF1737); Region: DUF1737; cl10503
224914007268	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
224914007269	dimer interface [polypeptide binding]; other site
224914007270	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914007271	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
224914007272	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
224914007273	active site
224914007274	Zn binding site [ion binding]; other site
224914007275	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
224914007276	MgtE intracellular N domain; Region: MgtE_N; cl15244
224914007277	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
224914007278	Divalent cation transporter; Region: MgtE; cl00786
224914007279	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
224914007280	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
224914007281	G1 box; other site
224914007282	putative GEF interaction site [polypeptide binding]; other site
224914007283	GTP/Mg2+ binding site [chemical binding]; other site
224914007284	Switch I region; other site
224914007285	G2 box; other site
224914007286	G3 box; other site
224914007287	Switch II region; other site
224914007288	G4 box; other site
224914007289	G5 box; other site
224914007290	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
224914007291	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
224914007292	Uncharacterized conserved protein [Function unknown]; Region: COG1739
224914007293	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
224914007294	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
224914007295	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
224914007296	AMP binding site [chemical binding]; other site
224914007297	metal binding site [ion binding]; metal-binding site
224914007298	active site
224914007299	hypothetical protein; Provisional; Region: PRK08185
224914007300	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
224914007301	intersubunit interface [polypeptide binding]; other site
224914007302	active site
224914007303	zinc binding site [ion binding]; other site
224914007304	Na+ binding site [ion binding]; other site
224914007305	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
224914007306	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
224914007307	substrate binding site [chemical binding]; other site
224914007308	dimer interface [polypeptide binding]; other site
224914007309	catalytic triad [active]
224914007310	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224914007311	Helix-turn-helix domains; Region: HTH; cl00088
224914007312	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914007313	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
224914007314	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
224914007315	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
224914007316	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
224914007317	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
224914007318	L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
224914007319	putative N- and C-terminal domain interface [polypeptide binding]; other site
224914007320	putative active site [active]
224914007321	putative MgATP binding site [chemical binding]; other site
224914007322	catalytic site [active]
224914007323	metal binding site [ion binding]; metal-binding site
224914007324	putative xylulose binding site [chemical binding]; other site
224914007325	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395
224914007326	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
224914007327	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
224914007328	Walker A/P-loop; other site
224914007329	ATP binding site [chemical binding]; other site
224914007330	Q-loop/lid; other site
224914007331	ABC transporter signature motif; other site
224914007332	Walker B; other site
224914007333	D-loop; other site
224914007334	H-loop/switch region; other site
224914007335	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
224914007336	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914007337	TM-ABC transporter signature motif; other site
224914007338	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
224914007339	ligand binding site [chemical binding]; other site
224914007340	dimerization interface [polypeptide binding]; other site
224914007341	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224914007342	Helix-turn-helix domains; Region: HTH; cl00088
224914007343	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914007344	hypothetical protein; Validated; Region: PRK08238
224914007345	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
224914007346	UbiA prenyltransferase family; Region: UbiA; cl00337
224914007347	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
224914007348	FAD binding domain; Region: FAD_binding_4; pfam01565
224914007349	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
224914007350	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
224914007351	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007352	NAD(P) binding site [chemical binding]; other site
224914007353	active site
224914007354	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
224914007355	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224914007356	inhibitor-cofactor binding pocket; inhibition site
224914007357	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914007358	catalytic residue [active]
224914007359	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914007360	Protein of unknown function DUF91; Region: DUF91; cl00709
224914007361	Uncharacterized conserved protein [Function unknown]; Region: COG3586
224914007362	Protein of unknown function DUF45; Region: DUF45; cl00636
224914007363	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
224914007364	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
224914007365	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224914007366	ATP binding site [chemical binding]; other site
224914007367	putative Mg++ binding site [ion binding]; other site
224914007368	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914007369	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
224914007370	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
224914007371	HsdM N-terminal domain; Region: HsdM_N; pfam12161
224914007372	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914007373	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
224914007374	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
224914007375	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
224914007376	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
224914007377	FMN binding site [chemical binding]; other site
224914007378	substrate binding site [chemical binding]; other site
224914007379	putative catalytic residue [active]
224914007380	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
224914007381	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224914007382	ATP binding site [chemical binding]; other site
224914007383	putative Mg++ binding site [ion binding]; other site
224914007384	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914007385	nucleotide binding region [chemical binding]; other site
224914007386	ATP-binding site [chemical binding]; other site
224914007387	DEAD/H associated; Region: DEAD_assoc; pfam08494
224914007388	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
224914007389	putative active site [active]
224914007390	putative metal binding site [ion binding]; other site
224914007391	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
224914007392	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
224914007393	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
224914007394	Sel1 repeat; Region: Sel1; cl02723
224914007395	Sel1 repeat; Region: Sel1; cl02723
224914007396	Sel1 repeat; Region: Sel1; cl02723
224914007397	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
224914007398	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
224914007399	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224914007400	DNA binding residues [nucleotide binding]
224914007401	putative dimer interface [polypeptide binding]; other site
224914007402	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
224914007403	CrcB-like protein; Region: CRCB; cl09114
224914007404	CrcB-like protein; Region: CRCB; cl09114
224914007405	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224914007406	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
224914007407	mannonate dehydratase; Region: uxuA; TIGR00695
224914007408	mannonate dehydratase; Provisional; Region: PRK03906
224914007409	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914007410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914007411	DNA-binding site [nucleotide binding]; DNA binding site
224914007412	FCD domain; Region: FCD; cl11656
224914007413	Glucuronate isomerase; Region: UxaC; cl00829
224914007414	Glucuronate isomerase; Region: UxaC; cl00829
224914007415	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
224914007416	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
224914007417	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
224914007418	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
224914007419	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007420	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
224914007421	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914007422	Walker A/P-loop; other site
224914007423	ATP binding site [chemical binding]; other site
224914007424	Q-loop/lid; other site
224914007425	ABC transporter signature motif; other site
224914007426	Walker B; other site
224914007427	D-loop; other site
224914007428	H-loop/switch region; other site
224914007429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007430	putative PBP binding loops; other site
224914007431	ABC-ATPase subunit interface; other site
224914007432	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914007433	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
224914007434	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
224914007435	nickel responsive regulator; Provisional; Region: PRK02967
224914007436	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
224914007437	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
224914007438	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
224914007439	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
224914007440	substrate binding site [chemical binding]; other site
224914007441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007442	dimer interface [polypeptide binding]; other site
224914007443	conserved gate region; other site
224914007444	putative PBP binding loops; other site
224914007445	ABC-ATPase subunit interface; other site
224914007446	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
224914007447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007448	dimer interface [polypeptide binding]; other site
224914007449	conserved gate region; other site
224914007450	putative PBP binding loops; other site
224914007451	ABC-ATPase subunit interface; other site
224914007452	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
224914007453	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914007454	Walker A/P-loop; other site
224914007455	ATP binding site [chemical binding]; other site
224914007456	Q-loop/lid; other site
224914007457	ABC transporter signature motif; other site
224914007458	Walker B; other site
224914007459	D-loop; other site
224914007460	H-loop/switch region; other site
224914007461	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
224914007462	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914007463	Walker A/P-loop; other site
224914007464	ATP binding site [chemical binding]; other site
224914007465	Q-loop/lid; other site
224914007466	ABC transporter signature motif; other site
224914007467	Walker B; other site
224914007468	D-loop; other site
224914007469	H-loop/switch region; other site
224914007470	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224914007471	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
224914007472	active site
224914007473	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
224914007474	putative dimerization interface [polypeptide binding]; other site
224914007475	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
224914007476	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
224914007477	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
224914007478	FAD binding site [chemical binding]; other site
224914007479	substrate binding site [chemical binding]; other site
224914007480	catalytic residues [active]
224914007481	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
224914007482	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
224914007483	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
224914007484	dimer interface [polypeptide binding]; other site
224914007485	active site
224914007486	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
224914007487	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914007488	substrate binding site [chemical binding]; other site
224914007489	oxyanion hole (OAH) forming residues; other site
224914007490	trimer interface [polypeptide binding]; other site
224914007491	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406
224914007492	LDH/MDH dimer interface [polypeptide binding]; other site
224914007493	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224914007494	Predicted transcriptional regulator [Transcription]; Region: COG2932
224914007495	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
224914007496	Catalytic site [active]
224914007497	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
224914007498	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
224914007499	Catalytic site; other site
224914007500	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
224914007501	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224914007502	active site
224914007503	nucleotide binding site [chemical binding]; other site
224914007504	HIGH motif; other site
224914007505	KMSKS motif; other site
224914007506	tellurite resistance protein terB; Region: terB; cd07176
224914007507	putative metal binding site [ion binding]; other site
224914007508	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
224914007509	active site clefts [active]
224914007510	zinc binding site [ion binding]; other site
224914007511	dimer interface [polypeptide binding]; other site
224914007512	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
224914007513	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
224914007514	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224914007515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007516	dimer interface [polypeptide binding]; other site
224914007517	conserved gate region; other site
224914007518	putative PBP binding loops; other site
224914007519	ABC-ATPase subunit interface; other site
224914007520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007521	dimer interface [polypeptide binding]; other site
224914007522	conserved gate region; other site
224914007523	putative PBP binding loops; other site
224914007524	ABC-ATPase subunit interface; other site
224914007525	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
224914007526	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914007527	Walker A/P-loop; other site
224914007528	ATP binding site [chemical binding]; other site
224914007529	Q-loop/lid; other site
224914007530	ABC transporter signature motif; other site
224914007531	Walker B; other site
224914007532	D-loop; other site
224914007533	H-loop/switch region; other site
224914007534	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
224914007535	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914007536	Walker A/P-loop; other site
224914007537	ATP binding site [chemical binding]; other site
224914007538	Q-loop/lid; other site
224914007539	ABC transporter signature motif; other site
224914007540	Walker B; other site
224914007541	D-loop; other site
224914007542	H-loop/switch region; other site
224914007543	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914007544	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
224914007545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007546	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
224914007547	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
224914007548	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
224914007549	homodimer interface [polypeptide binding]; other site
224914007550	NADP binding site [chemical binding]; other site
224914007551	substrate binding site [chemical binding]; other site
224914007552	Dehydratase family; Region: ILVD_EDD; cl00340
224914007553	6-phosphogluconate dehydratase; Region: edd; TIGR01196
224914007554	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
224914007555	putative active site [active]
224914007556	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
224914007557	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
224914007558	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
224914007559	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
224914007560	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224914007561	putative NAD(P) binding site [chemical binding]; other site
224914007562	active site
224914007563	drug efflux system protein MdtG; Provisional; Region: PRK09874
224914007564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914007565	putative substrate translocation pore; other site
224914007566	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
224914007567	AzlC protein; Region: AzlC; cl00570
224914007568	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224914007569	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914007570	putative DNA binding site [nucleotide binding]; other site
224914007571	putative Zn2+ binding site [ion binding]; other site
224914007572	Helix-turn-helix domains; Region: HTH; cl00088
224914007573	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
224914007574	Helix-turn-helix domains; Region: HTH; cl00088
224914007575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007576	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224914007577	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
224914007578	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
224914007579	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
224914007580	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
224914007581	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
224914007582	Helix-turn-helix domains; Region: HTH; cl00088
224914007583	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007584	dimerization interface [polypeptide binding]; other site
224914007585	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
224914007586	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
224914007587	generic binding surface II; other site
224914007588	generic binding surface I; other site
224914007589	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
224914007590	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
224914007591	RNA methyltransferase, RsmE family; Region: TIGR00046
224914007592	Transcriptional regulators [Transcription]; Region: MarR; COG1846
224914007593	Helix-turn-helix domains; Region: HTH; cl00088
224914007594	Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136
224914007595	Fusaric acid resistance protein family; Region: FUSC; pfam04632
224914007596	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
224914007597	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
224914007598	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
224914007599	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
224914007600	putative ligand binding residues [chemical binding]; other site
224914007601	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224914007602	ABC-ATPase subunit  interface; other site
224914007603	dimer interface [polypeptide binding]; other site
224914007604	putative PBP binding regions; other site
224914007605	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
224914007606	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
224914007607	Walker A/P-loop; other site
224914007608	ATP binding site [chemical binding]; other site
224914007609	Q-loop/lid; other site
224914007610	ABC transporter signature motif; other site
224914007611	Walker B; other site
224914007612	D-loop; other site
224914007613	H-loop/switch region; other site
224914007614	Uncharacterized conserved protein [Function unknown]; Region: COG5476
224914007615	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
224914007616	MlrC C-terminus; Region: MlrC_C; pfam07171
224914007617	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
224914007618	homotrimer interaction site [polypeptide binding]; other site
224914007619	putative active site [active]
224914007620	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224914007621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007622	dimer interface [polypeptide binding]; other site
224914007623	conserved gate region; other site
224914007624	putative PBP binding loops; other site
224914007625	ABC-ATPase subunit interface; other site
224914007626	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224914007627	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007628	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224914007629	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007630	NAD(P) binding site [chemical binding]; other site
224914007631	active site
224914007632	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
224914007633	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
224914007634	Walker A/P-loop; other site
224914007635	ATP binding site [chemical binding]; other site
224914007636	Q-loop/lid; other site
224914007637	ABC transporter signature motif; other site
224914007638	Walker B; other site
224914007639	D-loop; other site
224914007640	H-loop/switch region; other site
224914007641	TOBE domain; Region: TOBE_2; cl01440
224914007642	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
224914007643	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
224914007644	putative active site [active]
224914007645	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
224914007646	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
224914007647	dimer interface [polypeptide binding]; other site
224914007648	active site
224914007649	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224914007650	substrate binding site [chemical binding]; other site
224914007651	catalytic residue [active]
224914007652	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
224914007653	This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea.  This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily.  The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294
224914007654	Walker A/P-loop; other site
224914007655	ATP binding site [chemical binding]; other site
224914007656	Q-loop/lid; other site
224914007657	ABC transporter signature motif; other site
224914007658	Walker B; other site
224914007659	D-loop; other site
224914007660	H-loop/switch region; other site
224914007661	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
224914007662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007663	dimer interface [polypeptide binding]; other site
224914007664	conserved gate region; other site
224914007665	putative PBP binding loops; other site
224914007666	ABC-ATPase subunit interface; other site
224914007667	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
224914007668	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
224914007669	EamA-like transporter family; Region: EamA; cl01037
224914007670	BA14K-like protein; Region: BA14K; pfam07886
224914007671	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
224914007672	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
224914007673	putative active site [active]
224914007674	metal binding site [ion binding]; metal-binding site
224914007675	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
224914007676	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
224914007677	N-formylglutamate amidohydrolase; Region: FGase; cl01522
224914007678	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
224914007679	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
224914007680	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
224914007681	putative active site [active]
224914007682	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
224914007683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007684	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
224914007685	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
224914007686	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
224914007687	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
224914007688	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
224914007689	lipoyl attachment site [posttranslational modification]; other site
224914007690	glycine dehydrogenase; Provisional; Region: PRK05367
224914007691	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914007692	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914007693	catalytic residue [active]
224914007694	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
224914007695	tetramer interface [polypeptide binding]; other site
224914007696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914007697	catalytic residue [active]
224914007698	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
224914007699	Helix-turn-helix domains; Region: HTH; cl00088
224914007700	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
224914007701	Proline dehydrogenase; Region: Pro_dh; cl03282
224914007702	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
224914007703	Glutamate binding site [chemical binding]; other site
224914007704	NAD binding site [chemical binding]; other site
224914007705	catalytic residues [active]
224914007706	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
224914007707	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007709	dimer interface [polypeptide binding]; other site
224914007710	conserved gate region; other site
224914007711	putative PBP binding loops; other site
224914007712	ABC-ATPase subunit interface; other site
224914007713	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
224914007714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007715	dimer interface [polypeptide binding]; other site
224914007716	conserved gate region; other site
224914007717	putative PBP binding loops; other site
224914007718	ABC-ATPase subunit interface; other site
224914007719	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
224914007720	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914007721	Walker A/P-loop; other site
224914007722	ATP binding site [chemical binding]; other site
224914007723	Q-loop/lid; other site
224914007724	ABC transporter signature motif; other site
224914007725	Walker B; other site
224914007726	D-loop; other site
224914007727	H-loop/switch region; other site
224914007728	TOBE domain; Region: TOBE_2; cl01440
224914007729	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
224914007730	active site
224914007731	KduI/IolB family; Region: KduI; cl01508
224914007732	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
224914007733	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
224914007734	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
224914007735	PYR/PP interface [polypeptide binding]; other site
224914007736	dimer interface [polypeptide binding]; other site
224914007737	TPP binding site [chemical binding]; other site
224914007738	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
224914007739	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
224914007740	TPP-binding site [chemical binding]; other site
224914007741	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224914007742	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
224914007743	substrate binding site [chemical binding]; other site
224914007744	ATP binding site [chemical binding]; other site
224914007745	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
224914007746	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
224914007747	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
224914007748	putative active site [active]
224914007749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007750	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
224914007751	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
224914007752	HTH DNA binding domain; Region: HTH_13; pfam11972
224914007753	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
224914007754	Helix-turn-helix domains; Region: HTH; cl00088
224914007755	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
224914007756	dimerization interface [polypeptide binding]; other site
224914007757	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
224914007758	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
224914007759	dimer interface [polypeptide binding]; other site
224914007760	decamer (pentamer of dimers) interface [polypeptide binding]; other site
224914007761	catalytic triad [active]
224914007762	peroxidatic and resolving cysteines [active]
224914007763	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
224914007764	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
224914007765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914007766	metabolite-proton symporter; Region: 2A0106; TIGR00883
224914007767	putative substrate translocation pore; other site
224914007768	multicopper oxidase; Provisional; Region: PRK10965
224914007769	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914007770	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914007771	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914007772	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
224914007773	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
224914007774	E-class dimer interface [polypeptide binding]; other site
224914007775	P-class dimer interface [polypeptide binding]; other site
224914007776	active site
224914007777	Cu2+ binding site [ion binding]; other site
224914007778	Zn2+ binding site [ion binding]; other site
224914007779	FAD dependent oxidoreductase; Region: DAO; pfam01266
224914007780	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
224914007781	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
224914007782	Walker A/P-loop; other site
224914007783	ATP binding site [chemical binding]; other site
224914007784	Q-loop/lid; other site
224914007785	ABC transporter signature motif; other site
224914007786	Walker B; other site
224914007787	D-loop; other site
224914007788	H-loop/switch region; other site
224914007789	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007790	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
224914007791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007792	dimer interface [polypeptide binding]; other site
224914007793	conserved gate region; other site
224914007794	putative PBP binding loops; other site
224914007795	ABC-ATPase subunit interface; other site
224914007796	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
224914007797	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
224914007798	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
224914007799	active site
224914007800	homopentamer interface [polypeptide binding]; other site
224914007801	dimer interface [polypeptide binding]; other site
224914007802	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224914007803	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007805	dimer interface [polypeptide binding]; other site
224914007806	conserved gate region; other site
224914007807	putative PBP binding loops; other site
224914007808	ABC-ATPase subunit interface; other site
224914007809	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224914007810	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007811	dimer interface [polypeptide binding]; other site
224914007812	conserved gate region; other site
224914007813	putative PBP binding loops; other site
224914007814	ABC-ATPase subunit interface; other site
224914007815	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
224914007816	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
224914007817	Walker A/P-loop; other site
224914007818	ATP binding site [chemical binding]; other site
224914007819	Q-loop/lid; other site
224914007820	ABC transporter signature motif; other site
224914007821	Walker B; other site
224914007822	D-loop; other site
224914007823	H-loop/switch region; other site
224914007824	TOBE domain; Region: TOBE_2; cl01440
224914007825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914007826	putative transporter; Provisional; Region: PRK10504
224914007827	putative substrate translocation pore; other site
224914007828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914007829	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
224914007830	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914007831	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
224914007832	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224914007833	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914007834	Walker A/P-loop; other site
224914007835	ATP binding site [chemical binding]; other site
224914007836	Q-loop/lid; other site
224914007837	ABC transporter signature motif; other site
224914007838	Walker B; other site
224914007839	D-loop; other site
224914007840	H-loop/switch region; other site
224914007841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007842	dimer interface [polypeptide binding]; other site
224914007843	conserved gate region; other site
224914007844	putative PBP binding loops; other site
224914007845	ABC-ATPase subunit interface; other site
224914007846	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
224914007847	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224914007848	substrate binding pocket [chemical binding]; other site
224914007849	membrane-bound complex binding site; other site
224914007850	hinge residues; other site
224914007851	5-oxoprolinase; Region: PLN02666
224914007852	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
224914007853	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
224914007854	Helix-turn-helix domains; Region: HTH; cl00088
224914007855	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
224914007856	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
224914007857	Walker A/P-loop; other site
224914007858	ATP binding site [chemical binding]; other site
224914007859	Q-loop/lid; other site
224914007860	ABC transporter signature motif; other site
224914007861	Walker B; other site
224914007862	D-loop; other site
224914007863	H-loop/switch region; other site
224914007864	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
224914007865	ABC-ATPase subunit  interface; other site
224914007866	dimer interface [polypeptide binding]; other site
224914007867	putative PBP binding regions; other site
224914007868	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224914007869	ABC-ATPase subunit  interface; other site
224914007870	dimer interface [polypeptide binding]; other site
224914007871	putative PBP binding regions; other site
224914007872	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
224914007873	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
224914007874	putative ligand binding residues [chemical binding]; other site
224914007875	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
224914007876	NAD binding site [chemical binding]; other site
224914007877	catalytic residues [active]
224914007878	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
224914007879	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007880	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
224914007881	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
224914007882	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
224914007883	substrate-cofactor binding pocket; other site
224914007884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914007885	catalytic residue [active]
224914007886	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
224914007887	EamA-like transporter family; Region: EamA; cl01037
224914007888	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
224914007889	Permease family; Region: Xan_ur_permease; cl00967
224914007890	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
224914007891	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
224914007892	nucleoside/Zn binding site; other site
224914007893	dimer interface [polypeptide binding]; other site
224914007894	catalytic motif [active]
224914007895	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
224914007896	transmembrane helices; other site
224914007897	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
224914007898	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
224914007899	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
224914007900	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
224914007901	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
224914007902	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
224914007903	Walker A/P-loop; other site
224914007904	ATP binding site [chemical binding]; other site
224914007905	Q-loop/lid; other site
224914007906	ABC transporter signature motif; other site
224914007907	Walker B; other site
224914007908	D-loop; other site
224914007909	H-loop/switch region; other site
224914007910	TOBE domain; Region: TOBE_2; cl01440
224914007911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914007912	dimer interface [polypeptide binding]; other site
224914007913	conserved gate region; other site
224914007914	ABC-ATPase subunit interface; other site
224914007915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914007916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914007917	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224914007918	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007919	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
224914007920	active site
224914007921	dimer interface [polypeptide binding]; other site
224914007922	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
224914007923	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224914007924	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
224914007925	active site
224914007926	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224914007927	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
224914007928	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
224914007929	Walker A/P-loop; other site
224914007930	ATP binding site [chemical binding]; other site
224914007931	Q-loop/lid; other site
224914007932	ABC transporter signature motif; other site
224914007933	Walker B; other site
224914007934	D-loop; other site
224914007935	H-loop/switch region; other site
224914007936	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
224914007937	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
224914007938	Walker A/P-loop; other site
224914007939	ATP binding site [chemical binding]; other site
224914007940	Q-loop/lid; other site
224914007941	ABC transporter signature motif; other site
224914007942	Walker B; other site
224914007943	D-loop; other site
224914007944	H-loop/switch region; other site
224914007945	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
224914007946	TM-ABC transporter signature motif; other site
224914007947	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
224914007948	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
224914007949	TM-ABC transporter signature motif; other site
224914007950	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
224914007951	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914007952	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
224914007953	tetramer interface [polypeptide binding]; other site
224914007954	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
224914007955	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
224914007956	heterodimer interface [polypeptide binding]; other site
224914007957	active site
224914007958	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
224914007959	active site
224914007960	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
224914007961	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
224914007962	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
224914007963	Helix-turn-helix domains; Region: HTH; cl00088
224914007964	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914007965	dimerization interface [polypeptide binding]; other site
224914007966	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
224914007967	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914007968	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
224914007969	Cupin domain; Region: Cupin_2; cl09118
224914007970	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914007971	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
224914007972	Helix-turn-helix domains; Region: HTH; cl00088
224914007973	Bacterial transcriptional regulator; Region: IclR; pfam01614
224914007974	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914007975	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914007976	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914007977	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
224914007978	active site
224914007979	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914007980	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224914007981	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914007982	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
224914007983	active site
224914007984	substrate binding site [chemical binding]; other site
224914007985	catalytic site [active]
224914007986	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126
224914007987	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914007988	metal binding site [ion binding]; metal-binding site
224914007989	active site
224914007990	I-site; other site
224914007991	Uncharacterized conserved protein [Function unknown]; Region: COG3391
224914007992	DNA polymerase IV; Provisional; Region: PRK02794
224914007993	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
224914007994	active site
224914007995	DNA binding site [nucleotide binding]
224914007996	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
224914007997	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
224914007998	Response regulator receiver domain; Region: Response_reg; pfam00072
224914007999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914008000	active site
224914008001	phosphorylation site [posttranslational modification]
224914008002	intermolecular recognition site; other site
224914008003	dimerization interface [polypeptide binding]; other site
224914008004	response regulator PleD; Reviewed; Region: pleD; PRK09581
224914008005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914008006	active site
224914008007	phosphorylation site [posttranslational modification]
224914008008	intermolecular recognition site; other site
224914008009	dimerization interface [polypeptide binding]; other site
224914008010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914008011	active site
224914008012	phosphorylation site [posttranslational modification]
224914008013	intermolecular recognition site; other site
224914008014	dimerization interface [polypeptide binding]; other site
224914008015	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914008016	metal binding site [ion binding]; metal-binding site
224914008017	active site
224914008018	I-site; other site
224914008019	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
224914008020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914008021	putative substrate translocation pore; other site
224914008022	Protein of unknown function (DUF983); Region: DUF983; cl02211
224914008023	ribonuclease R; Region: RNase_R; TIGR02063
224914008024	RNB domain; Region: RNB; pfam00773
224914008025	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
224914008026	RNA binding site [nucleotide binding]; other site
224914008027	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
224914008028	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
224914008029	active site
224914008030	interdomain interaction site; other site
224914008031	putative metal-binding site [ion binding]; other site
224914008032	nucleotide binding site [chemical binding]; other site
224914008033	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
224914008034	domain I; other site
224914008035	DNA binding groove [nucleotide binding]
224914008036	phosphate binding site [ion binding]; other site
224914008037	domain II; other site
224914008038	domain III; other site
224914008039	nucleotide binding site [chemical binding]; other site
224914008040	catalytic site [active]
224914008041	domain IV; other site
224914008042	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
224914008043	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
224914008044	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
224914008045	Domain of unknown function (DUF205); Region: DUF205; cl00410
224914008046	dihydroorotase; Validated; Region: PRK09059
224914008047	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224914008048	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
224914008049	active site
224914008050	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
224914008051	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
224914008052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008053	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
224914008054	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224914008055	active site
224914008056	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
224914008057	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
224914008058	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
224914008059	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
224914008060	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
224914008061	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
224914008062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914008063	Mg2+ binding site [ion binding]; other site
224914008064	G-X-G motif; other site
224914008065	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
224914008066	anchoring element; other site
224914008067	dimer interface [polypeptide binding]; other site
224914008068	ATP binding site [chemical binding]; other site
224914008069	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
224914008070	active site
224914008071	metal binding site [ion binding]; metal-binding site
224914008072	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
224914008073	EamA-like transporter family; Region: EamA; cl01037
224914008074	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
224914008075	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
224914008076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224914008077	PAS fold; Region: PAS_3; pfam08447
224914008078	putative active site [active]
224914008079	heme pocket [chemical binding]; other site
224914008080	PAS fold; Region: PAS_3; pfam08447
224914008081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224914008082	putative active site [active]
224914008083	heme pocket [chemical binding]; other site
224914008084	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
224914008085	Histidine kinase; Region: HisKA_2; cl06527
224914008086	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
224914008087	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
224914008088	Predicted integral membrane protein [Function unknown]; Region: COG0392
224914008089	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
224914008090	Uncharacterized conserved protein [Function unknown]; Region: COG2898
224914008091	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
224914008092	LysE type translocator; Region: LysE; cl00565
224914008093	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
224914008094	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
224914008095	Substrate binding site; other site
224914008096	Mg++ binding site; other site
224914008097	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
224914008098	active site
224914008099	substrate binding site [chemical binding]; other site
224914008100	CoA binding site [chemical binding]; other site
224914008101	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
224914008102	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
224914008103	glutaminase active site [active]
224914008104	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
224914008105	dimer interface [polypeptide binding]; other site
224914008106	active site
224914008107	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
224914008108	dimer interface [polypeptide binding]; other site
224914008109	active site
224914008110	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
224914008111	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
224914008112	generic binding surface II; other site
224914008113	ssDNA binding site; other site
224914008114	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224914008115	ATP binding site [chemical binding]; other site
224914008116	putative Mg++ binding site [ion binding]; other site
224914008117	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914008118	nucleotide binding region [chemical binding]; other site
224914008119	ATP-binding site [chemical binding]; other site
224914008120	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
224914008121	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
224914008122	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
224914008123	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224914008124	ATP binding site [chemical binding]; other site
224914008125	putative Mg++ binding site [ion binding]; other site
224914008126	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224914008127	nucleotide binding region [chemical binding]; other site
224914008128	ATP-binding site [chemical binding]; other site
224914008129	TRCF domain; Region: TRCF; cl04088
224914008130	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
224914008131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914008132	active site
224914008133	metal binding site [ion binding]; metal-binding site
224914008134	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
224914008135	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
224914008136	catalytic residues [active]
224914008137	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
224914008138	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
224914008139	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
224914008140	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548
224914008141	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
224914008142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008143	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
224914008144	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
224914008145	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
224914008146	NADP binding site [chemical binding]; other site
224914008147	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
224914008148	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
224914008149	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
224914008150	Walker A/P-loop; other site
224914008151	ATP binding site [chemical binding]; other site
224914008152	Q-loop/lid; other site
224914008153	ABC transporter signature motif; other site
224914008154	Walker B; other site
224914008155	D-loop; other site
224914008156	H-loop/switch region; other site
224914008157	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
224914008158	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
224914008159	TM-ABC transporter signature motif; other site
224914008160	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
224914008161	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
224914008162	TM-ABC transporter signature motif; other site
224914008163	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
224914008164	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
224914008165	putative ligand binding site [chemical binding]; other site
224914008166	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
224914008167	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224914008168	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914008169	FeS/SAM binding site; other site
224914008170	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
224914008171	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
224914008172	heme binding site [chemical binding]; other site
224914008173	ferroxidase pore; other site
224914008174	ferroxidase diiron center [ion binding]; other site
224914008175	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
224914008176	Helix-turn-helix domains; Region: HTH; cl00088
224914008177	Predicted transcriptional regulator [Transcription]; Region: COG1959
224914008178	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
224914008179	putative deacylase active site [active]
224914008180	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914008181	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
224914008182	Helix-turn-helix domains; Region: HTH; cl00088
224914008183	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
224914008184	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
224914008185	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
224914008186	Integrase core domain; Region: rve; cl01316
224914008187	Integrase core domain; Region: rve; cl01316
224914008188	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
224914008189	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914008190	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914008191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
224914008192	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
224914008193	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914008194	Protein of unknown function (DUF995); Region: DUF995; pfam06191
224914008195	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
224914008196	Protein of unknown function (DUF995); Region: DUF995; pfam06191
224914008197	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
224914008198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008199	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
224914008200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008201	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
224914008202	cellulose synthase A (UDP-forming), catalytic subunit; Region: PLN02638
224914008203	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
224914008204	active site
224914008205	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
224914008206	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
224914008207	NAD binding site [chemical binding]; other site
224914008208	homodimer interface [polypeptide binding]; other site
224914008209	active site
224914008210	substrate binding site [chemical binding]; other site
224914008211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008212	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
224914008213	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
224914008214	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
224914008215	peptide binding site [polypeptide binding]; other site
224914008216	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
224914008217	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
224914008218	peptide binding site [polypeptide binding]; other site
224914008219	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
224914008220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008221	dimer interface [polypeptide binding]; other site
224914008222	conserved gate region; other site
224914008223	putative PBP binding loops; other site
224914008224	ABC-ATPase subunit interface; other site
224914008225	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
224914008226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008227	dimer interface [polypeptide binding]; other site
224914008228	conserved gate region; other site
224914008229	ABC-ATPase subunit interface; other site
224914008230	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
224914008231	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914008232	Walker A/P-loop; other site
224914008233	ATP binding site [chemical binding]; other site
224914008234	Q-loop/lid; other site
224914008235	ABC transporter signature motif; other site
224914008236	Walker B; other site
224914008237	D-loop; other site
224914008238	H-loop/switch region; other site
224914008239	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914008240	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914008241	Walker A/P-loop; other site
224914008242	ATP binding site [chemical binding]; other site
224914008243	Q-loop/lid; other site
224914008244	ABC transporter signature motif; other site
224914008245	Walker B; other site
224914008246	D-loop; other site
224914008247	H-loop/switch region; other site
224914008248	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914008249	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
224914008250	benzoate transport; Region: 2A0115; TIGR00895
224914008251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914008252	putative substrate translocation pore; other site
224914008253	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
224914008254	homodimer interface [polypeptide binding]; other site
224914008255	homotetramer interface [polypeptide binding]; other site
224914008256	active site pocket [active]
224914008257	cleavage site
224914008258	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008259	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
224914008260	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
224914008261	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
224914008262	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
224914008263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008264	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
224914008265	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224914008266	E3 interaction surface; other site
224914008267	lipoyl attachment site [posttranslational modification]; other site
224914008268	e3 binding domain; Region: E3_binding; pfam02817
224914008269	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
224914008270	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
224914008271	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
224914008272	alpha subunit interface [polypeptide binding]; other site
224914008273	TPP binding site [chemical binding]; other site
224914008274	heterodimer interface [polypeptide binding]; other site
224914008275	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224914008276	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
224914008277	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
224914008278	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
224914008279	tetramer interface [polypeptide binding]; other site
224914008280	TPP-binding site [chemical binding]; other site
224914008281	heterodimer interface [polypeptide binding]; other site
224914008282	phosphorylation loop region [posttranslational modification]
224914008283	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
224914008284	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
224914008285	Walker A/P-loop; other site
224914008286	ATP binding site [chemical binding]; other site
224914008287	Q-loop/lid; other site
224914008288	ABC transporter signature motif; other site
224914008289	Walker B; other site
224914008290	D-loop; other site
224914008291	H-loop/switch region; other site
224914008292	TOBE domain; Region: TOBE_2; cl01440
224914008293	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914008294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008295	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224914008296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008297	dimer interface [polypeptide binding]; other site
224914008298	conserved gate region; other site
224914008299	putative PBP binding loops; other site
224914008300	ABC-ATPase subunit interface; other site
224914008301	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
224914008302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008303	dimer interface [polypeptide binding]; other site
224914008304	conserved gate region; other site
224914008305	putative PBP binding loops; other site
224914008306	ABC-ATPase subunit interface; other site
224914008307	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914008308	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914008309	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
224914008310	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
224914008311	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
224914008312	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914008313	DNA-binding site [nucleotide binding]; DNA binding site
224914008314	UTRA domain; Region: UTRA; cl01230
224914008315	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
224914008316	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
224914008317	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
224914008318	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
224914008319	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
224914008320	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
224914008321	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008322	Walker A/P-loop; other site
224914008323	ATP binding site [chemical binding]; other site
224914008324	Q-loop/lid; other site
224914008325	ABC transporter signature motif; other site
224914008326	Walker B; other site
224914008327	D-loop; other site
224914008328	H-loop/switch region; other site
224914008329	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
224914008330	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914008331	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228
224914008332	Walker A/P-loop; other site
224914008333	ATP binding site [chemical binding]; other site
224914008334	Q-loop/lid; other site
224914008335	ABC transporter signature motif; other site
224914008336	Walker B; other site
224914008337	D-loop; other site
224914008338	H-loop/switch region; other site
224914008339	Predicted transcriptional regulators [Transcription]; Region: COG1510
224914008340	Helix-turn-helix domains; Region: HTH; cl00088
224914008341	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
224914008342	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
224914008343	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
224914008344	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
224914008345	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
224914008346	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
224914008347	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
224914008348	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
224914008349	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
224914008350	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
224914008351	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
224914008352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
224914008353	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
224914008354	dimer interface [polypeptide binding]; other site
224914008355	FMN binding site [chemical binding]; other site
224914008356	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
224914008357	MPT binding site; other site
224914008358	trimer interface [polypeptide binding]; other site
224914008359	biotin synthase; Region: bioB; TIGR00433
224914008360	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224914008361	FeS/SAM binding site; other site
224914008362	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
224914008363	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
224914008364	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914008365	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914008366	catalytic residue [active]
224914008367	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: PLN02974
224914008368	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008369	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
224914008370	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224914008371	inhibitor-cofactor binding pocket; inhibition site
224914008372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224914008373	catalytic residue [active]
224914008374	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
224914008375	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
224914008376	dimer interface [polypeptide binding]; other site
224914008377	active site
224914008378	CoA binding pocket [chemical binding]; other site
224914008379	homoserine O-succinyltransferase; Provisional; Region: PRK05368
224914008380	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
224914008381	proposed active site lysine [active]
224914008382	conserved cys residue [active]
224914008383	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
224914008384	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
224914008385	active site
224914008386	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
224914008387	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
224914008388	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224914008389	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
224914008390	Helix-turn-helix domains; Region: HTH; cl00088
224914008391	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
224914008392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008393	Protein of unknown function, DUF488; Region: DUF488; cl01246
224914008394	osmolarity response regulator; Provisional; Region: ompR; PRK09468
224914008395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914008396	active site
224914008397	phosphorylation site [posttranslational modification]
224914008398	intermolecular recognition site; other site
224914008399	dimerization interface [polypeptide binding]; other site
224914008400	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914008401	DNA binding site [nucleotide binding]
224914008402	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224914008403	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
224914008404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914008405	dimer interface [polypeptide binding]; other site
224914008406	phosphorylation site [posttranslational modification]
224914008407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914008408	ATP binding site [chemical binding]; other site
224914008409	Mg2+ binding site [ion binding]; other site
224914008410	G-X-G motif; other site
224914008411	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
224914008412	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
224914008413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914008414	putative substrate translocation pore; other site
224914008415	Helix-turn-helix domains; Region: HTH; cl00088
224914008416	NMT1-like family; Region: NMT1_2; cl15260
224914008417	NMT1/THI5 like; Region: NMT1; pfam09084
224914008418	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
224914008419	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
224914008420	Walker A/P-loop; other site
224914008421	ATP binding site [chemical binding]; other site
224914008422	Q-loop/lid; other site
224914008423	ABC transporter signature motif; other site
224914008424	Walker B; other site
224914008425	D-loop; other site
224914008426	H-loop/switch region; other site
224914008427	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
224914008428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008429	dimer interface [polypeptide binding]; other site
224914008430	conserved gate region; other site
224914008431	putative PBP binding loops; other site
224914008432	ABC-ATPase subunit interface; other site
224914008433	Cupin domain; Region: Cupin_2; cl09118
224914008434	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
224914008435	ABC-2 type transporter; Region: ABC2_membrane; cl11417
224914008436	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224914008437	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
224914008438	Walker A/P-loop; other site
224914008439	ATP binding site [chemical binding]; other site
224914008440	Q-loop/lid; other site
224914008441	ABC transporter signature motif; other site
224914008442	Walker B; other site
224914008443	D-loop; other site
224914008444	H-loop/switch region; other site
224914008445	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
224914008446	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914008447	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
224914008448	Helix-turn-helix domains; Region: HTH; cl00088
224914008449	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
224914008450	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
224914008451	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
224914008452	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914008453	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914008454	DNA-binding site [nucleotide binding]; DNA binding site
224914008455	FCD domain; Region: FCD; cl11656
224914008456	YeeE/YedE family (DUF395); Region: DUF395; cl01018
224914008457	YeeE/YedE family (DUF395); Region: DUF395; cl01018
224914008458	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224914008459	dimerization interface [polypeptide binding]; other site
224914008460	putative DNA binding site [nucleotide binding]; other site
224914008461	putative Zn2+ binding site [ion binding]; other site
224914008462	Protein of unknown function (DUF808); Region: DUF808; cl01002
224914008463	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
224914008464	active site
224914008465	catalytic residues [active]
224914008466	metal binding site [ion binding]; metal-binding site
224914008467	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
224914008468	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008469	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
224914008470	L-serine binding site [chemical binding]; other site
224914008471	ACT domain interface; other site
224914008472	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
224914008473	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224914008474	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914008475	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
224914008476	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
224914008477	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
224914008478	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
224914008479	NAD binding site [chemical binding]; other site
224914008480	homotetramer interface [polypeptide binding]; other site
224914008481	homodimer interface [polypeptide binding]; other site
224914008482	active site
224914008483	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
224914008484	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
224914008485	dimer interface [polypeptide binding]; other site
224914008486	active site
224914008487	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
224914008488	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
224914008489	active site
224914008490	SelR domain; Region: SelR; cl00369
224914008491	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
224914008492	Helix-turn-helix domains; Region: HTH; cl00088
224914008493	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
224914008494	putative dimerization interface [polypeptide binding]; other site
224914008495	putative substrate binding pocket [chemical binding]; other site
224914008496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914008497	putative substrate translocation pore; other site
224914008498	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224914008499	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
224914008500	catalytic site [active]
224914008501	metal binding site [ion binding]; metal-binding site
224914008502	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
224914008503	N- and C-terminal domain interface [polypeptide binding]; other site
224914008504	active site
224914008505	MgATP binding site [chemical binding]; other site
224914008506	metal binding site [ion binding]; metal-binding site
224914008507	Permease family; Region: Xan_ur_permease; cl00967
224914008508	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
224914008509	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
224914008510	active site
224914008511	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
224914008512	Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421
224914008513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914008514	Cupin domain; Region: Cupin_2; cl09118
224914008515	Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310
224914008516	M28 Zn-Peptidases; Region: M28_like_3; cd05644
224914008517	active site
224914008518	metal binding site [ion binding]; metal-binding site
224914008519	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
224914008520	extended (e) SDRs; Region: SDR_e; cd08946
224914008521	NAD(P) binding site [chemical binding]; other site
224914008522	active site
224914008523	substrate binding site [chemical binding]; other site
224914008524	Putative endoglucanase; Region: Glyco_hydro_101; pfam12905
224914008525	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
224914008526	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914008527	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914008528	catalytic residue [active]
224914008529	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
224914008530	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
224914008531	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224914008532	active site
224914008533	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
224914008534	MatE; Region: MatE; cl10513
224914008535	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
224914008536	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
224914008537	Mg++ binding site [ion binding]; other site
224914008538	putative catalytic motif [active]
224914008539	substrate binding site [chemical binding]; other site
224914008540	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224914008541	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
224914008542	putative metal binding site; other site
224914008543	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
224914008544	putative active site [active]
224914008545	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
224914008546	putative trimer interface [polypeptide binding]; other site
224914008547	putative active site [active]
224914008548	putative substrate binding site [chemical binding]; other site
224914008549	putative CoA binding site [chemical binding]; other site
224914008550	Surface antigen; Region: Surface_Ag_2; cl01155
224914008551	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
224914008552	putative ADP-binding pocket [chemical binding]; other site
224914008553	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
224914008554	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224914008555	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
224914008556	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
224914008557	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
224914008558	NADP-binding site; other site
224914008559	homotetramer interface [polypeptide binding]; other site
224914008560	substrate binding site [chemical binding]; other site
224914008561	homodimer interface [polypeptide binding]; other site
224914008562	active site
224914008563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008564	NAD(P) binding site [chemical binding]; other site
224914008565	active site
224914008566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008567	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
224914008568	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
224914008569	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
224914008570	Chain length determinant protein; Region: Wzz; cl01623
224914008571	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
224914008572	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008573	G3 box; other site
224914008574	Switch II region; other site
224914008575	G4 box; other site
224914008576	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224914008577	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224914008578	DNA binding residues [nucleotide binding]
224914008579	dimerization interface [polypeptide binding]; other site
224914008580	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224914008581	ligand binding site [chemical binding]; other site
224914008582	flexible hinge region; other site
224914008583	Helix-turn-helix domains; Region: HTH; cl00088
224914008584	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
224914008585	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
224914008586	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
224914008587	putative active site cavity [active]
224914008588	N-acetylmannosamine kinase; Provisional; Region: PRK05082
224914008589	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
224914008590	Transcriptional regulators [Transcription]; Region: FadR; COG2186
224914008591	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914008592	DNA-binding site [nucleotide binding]; DNA binding site
224914008593	FCD domain; Region: FCD; cl11656
224914008594	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
224914008595	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
224914008596	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224914008597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008598	dimer interface [polypeptide binding]; other site
224914008599	conserved gate region; other site
224914008600	putative PBP binding loops; other site
224914008601	ABC-ATPase subunit interface; other site
224914008602	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
224914008603	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
224914008604	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008605	dimer interface [polypeptide binding]; other site
224914008606	conserved gate region; other site
224914008607	putative PBP binding loops; other site
224914008608	ABC-ATPase subunit interface; other site
224914008609	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
224914008610	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
224914008611	inhibitor site; inhibition site
224914008612	active site
224914008613	dimer interface [polypeptide binding]; other site
224914008614	catalytic residue [active]
224914008615	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224914008616	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914008617	Walker A/P-loop; other site
224914008618	ATP binding site [chemical binding]; other site
224914008619	Q-loop/lid; other site
224914008620	ABC transporter signature motif; other site
224914008621	Walker B; other site
224914008622	D-loop; other site
224914008623	H-loop/switch region; other site
224914008624	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914008625	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
224914008626	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
224914008627	Walker A/P-loop; other site
224914008628	ATP binding site [chemical binding]; other site
224914008629	Q-loop/lid; other site
224914008630	ABC transporter signature motif; other site
224914008631	Walker B; other site
224914008632	D-loop; other site
224914008633	H-loop/switch region; other site
224914008634	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224914008635	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008636	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914008637	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914008638	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008639	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
224914008640	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
224914008641	NAD binding site [chemical binding]; other site
224914008642	catalytic Zn binding site [ion binding]; other site
224914008643	substrate binding site [chemical binding]; other site
224914008644	structural Zn binding site [ion binding]; other site
224914008645	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
224914008646	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914008647	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224914008648	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
224914008649	tetramerization interface [polypeptide binding]; other site
224914008650	NAD(P) binding site [chemical binding]; other site
224914008651	catalytic residues [active]
224914008652	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008653	choline dehydrogenase; Validated; Region: PRK02106
224914008654	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
224914008655	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
224914008656	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
224914008657	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
224914008658	shikimate binding site; other site
224914008659	NAD(P) binding site [chemical binding]; other site
224914008660	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224914008661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008662	NAD(P) binding site [chemical binding]; other site
224914008663	active site
224914008664	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
224914008665	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
224914008666	Walker A/P-loop; other site
224914008667	ATP binding site [chemical binding]; other site
224914008668	Q-loop/lid; other site
224914008669	ABC transporter signature motif; other site
224914008670	Walker B; other site
224914008671	D-loop; other site
224914008672	H-loop/switch region; other site
224914008673	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
224914008674	TM-ABC transporter signature motif; other site
224914008675	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
224914008676	TM-ABC transporter signature motif; other site
224914008677	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
224914008678	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
224914008679	Walker A/P-loop; other site
224914008680	ATP binding site [chemical binding]; other site
224914008681	Q-loop/lid; other site
224914008682	ABC transporter signature motif; other site
224914008683	Walker B; other site
224914008684	D-loop; other site
224914008685	H-loop/switch region; other site
224914008686	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
224914008687	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224914008688	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
224914008689	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
224914008690	NAD(P) binding site [chemical binding]; other site
224914008691	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914008692	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914008693	DNA-binding site [nucleotide binding]; DNA binding site
224914008694	FCD domain; Region: FCD; cl11656
224914008695	Cytochrome P450; Region: p450; cl12078
224914008696	Acetokinase family; Region: Acetate_kinase; cl01029
224914008697	putative phosphoketolase; Provisional; Region: PRK05261
224914008698	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
224914008699	TPP-binding site; other site
224914008700	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
224914008701	XFP C-terminal domain; Region: XFP_C; pfam09363
224914008702	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
224914008703	4Fe-4S binding domain; Region: Fer4_5; pfam12801
224914008704	Iron permease FTR1 family; Region: FTR1; cl00475
224914008705	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914008706	Fe2+ transport protein; Region: Iron_transport; cl01377
224914008707	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
224914008708	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
224914008709	AMP/PPi binding site [chemical binding]; other site
224914008710	candidate oxyanion hole; other site
224914008711	catalytic triad [active]
224914008712	potential glutamine specificity residues [chemical binding]; other site
224914008713	GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519
224914008714	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
224914008715	ATP Binding subdomain [chemical binding]; other site
224914008716	Ligand Binding sites [chemical binding]; other site
224914008717	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
224914008718	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
224914008719	CoenzymeA binding site [chemical binding]; other site
224914008720	subunit interaction site [polypeptide binding]; other site
224914008721	PHB binding site; other site
224914008722	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
224914008723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914008724	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
224914008725	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
224914008726	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
224914008727	tetramer interface [polypeptide binding]; other site
224914008728	heme binding pocket [chemical binding]; other site
224914008729	NADPH binding site [chemical binding]; other site
224914008730	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
224914008731	Helix-turn-helix domains; Region: HTH; cl00088
224914008732	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
224914008733	dimerization interface [polypeptide binding]; other site
224914008734	Cytochrome c [Energy production and conversion]; Region: COG3258
224914008735	Cytochrome c; Region: Cytochrom_C; cl11414
224914008736	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
224914008737	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
224914008738	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
224914008739	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
224914008740	active site
224914008741	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
224914008742	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
224914008743	putative ion selectivity filter; other site
224914008744	putative pore gating glutamate residue; other site
224914008745	putative H+/Cl- coupling transport residue; other site
224914008746	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
224914008747	putative active site pocket [active]
224914008748	cleavage site
224914008749	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
224914008750	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
224914008751	active site
224914008752	substrate binding site [chemical binding]; other site
224914008753	metal binding site [ion binding]; metal-binding site
224914008754	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
224914008755	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
224914008756	Substrate binding site; other site
224914008757	Cupin domain; Region: Cupin_2; cl09118
224914008758	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914008759	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914008760	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
224914008761	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
224914008762	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224914008763	HdeA/HdeB family; Region: HdeA; cl05752
224914008764	Glutaminase; Region: Glutaminase; cl00907
224914008765	Glutaminase; Region: Glutaminase; cl00907
224914008766	Amino acid permease; Region: AA_permease; cl00524
224914008767	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
224914008768	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914008769	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224914008770	catalytic residue [active]
224914008771	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224914008772	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
224914008773	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224914008774	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
224914008775	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
224914008776	Helix-turn-helix domains; Region: HTH; cl00088
224914008777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008778	dimer interface [polypeptide binding]; other site
224914008779	conserved gate region; other site
224914008780	putative PBP binding loops; other site
224914008781	ABC-ATPase subunit interface; other site
224914008782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008783	dimer interface [polypeptide binding]; other site
224914008784	conserved gate region; other site
224914008785	putative PBP binding loops; other site
224914008786	ABC-ATPase subunit interface; other site
224914008787	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
224914008788	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
224914008789	Walker A/P-loop; other site
224914008790	ATP binding site [chemical binding]; other site
224914008791	Q-loop/lid; other site
224914008792	ABC transporter signature motif; other site
224914008793	Walker B; other site
224914008794	D-loop; other site
224914008795	H-loop/switch region; other site
224914008796	TOBE domain; Region: TOBE_2; cl01440
224914008797	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
224914008798	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914008799	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
224914008800	Septum formation topological specificity factor MinE; Region: MinE; cl00538
224914008801	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
224914008802	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
224914008803	Switch I; other site
224914008804	Switch II; other site
224914008805	septum formation inhibitor; Reviewed; Region: minC; PRK05177
224914008806	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
224914008807	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
224914008808	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
224914008809	dimer interface [polypeptide binding]; other site
224914008810	putative radical transfer pathway; other site
224914008811	diiron center [ion binding]; other site
224914008812	tyrosyl radical; other site
224914008813	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
224914008814	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
224914008815	Class I ribonucleotide reductase; Region: RNR_I; cd01679
224914008816	active site
224914008817	dimer interface [polypeptide binding]; other site
224914008818	catalytic residues [active]
224914008819	effector binding site; other site
224914008820	R2 peptide binding site; other site
224914008821	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
224914008822	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
224914008823	catalytic residues [active]
224914008824	Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977
224914008825	Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977
224914008826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914008827	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914008828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914008829	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
224914008830	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
224914008831	conserved cys residue [active]
224914008832	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008833	ABC transporter signature motif; other site
224914008834	Walker B; other site
224914008835	D-loop; other site
224914008836	H-loop/switch region; other site
224914008837	TOBE domain; Region: TOBE_2; cl01440
224914008838	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008839	Walker A/P-loop; other site
224914008840	ATP binding site [chemical binding]; other site
224914008841	Q-loop/lid; other site
224914008842	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224914008843	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008844	dimer interface [polypeptide binding]; other site
224914008845	conserved gate region; other site
224914008846	putative PBP binding loops; other site
224914008847	ABC-ATPase subunit interface; other site
224914008848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008849	putative PBP binding loops; other site
224914008850	dimer interface [polypeptide binding]; other site
224914008851	ABC-ATPase subunit interface; other site
224914008852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
224914008853	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224914008854	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914008855	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224914008856	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224914008857	DNA binding site [nucleotide binding]
224914008858	domain linker motif; other site
224914008859	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
224914008860	ligand binding site [chemical binding]; other site
224914008861	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
224914008862	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224914008863	ligand binding site [chemical binding]; other site
224914008864	flexible hinge region; other site
224914008865	Helix-turn-helix domains; Region: HTH; cl00088
224914008866	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
224914008867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914008868	putative substrate translocation pore; other site
224914008869	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
224914008870	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
224914008871	[4Fe-4S] binding site [ion binding]; other site
224914008872	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
224914008873	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
224914008874	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
224914008875	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
224914008876	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
224914008877	molybdopterin cofactor binding site; other site
224914008878	nitrate reductase, beta subunit; Region: narH; TIGR01660
224914008879	4Fe-4S binding domain; Region: Fer4; cl02805
224914008880	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
224914008881	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
224914008882	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
224914008883	PPIC-type PPIASE domain; Region: Rotamase; cl08278
224914008884	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008885	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
224914008886	Flavoprotein; Region: Flavoprotein; cl08021
224914008887	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
224914008888	SCP-2 sterol transfer family; Region: SCP2; cl01225
224914008889	Peptidase family U32; Region: Peptidase_U32; cl03113
224914008890	Peptidase family U32; Region: Peptidase_U32; cl03113
224914008891	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
224914008892	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
224914008893	Walker A/P-loop; other site
224914008894	ATP binding site [chemical binding]; other site
224914008895	Q-loop/lid; other site
224914008896	ABC transporter signature motif; other site
224914008897	Walker B; other site
224914008898	D-loop; other site
224914008899	H-loop/switch region; other site
224914008900	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
224914008901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914008902	dimer interface [polypeptide binding]; other site
224914008903	conserved gate region; other site
224914008904	putative PBP binding loops; other site
224914008905	ABC-ATPase subunit interface; other site
224914008906	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
224914008907	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
224914008908	NnrS protein; Region: NnrS; cl01258
224914008909	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914008910	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
224914008911	Helix-turn-helix domains; Region: HTH; cl00088
224914008912	ApbE family; Region: ApbE; cl00643
224914008913	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
224914008914	NosL; Region: NosL; cl01769
224914008915	ABC-2 type transporter; Region: ABC2_membrane; cl11417
224914008916	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224914008917	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008918	Walker A/P-loop; other site
224914008919	ATP binding site [chemical binding]; other site
224914008920	Q-loop/lid; other site
224914008921	ABC transporter signature motif; other site
224914008922	Walker B; other site
224914008923	D-loop; other site
224914008924	H-loop/switch region; other site
224914008925	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
224914008926	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
224914008927	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
224914008928	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
224914008929	nitrous-oxide reductase; Validated; Region: PRK02888
224914008930	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914008931	nitrous-oxide reductase; Validated; Region: PRK02888
224914008932	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
224914008933	FMN-binding domain; Region: FMN_bind; cl01081
224914008934	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
224914008935	4Fe-4S binding domain; Region: Fer4_5; pfam12801
224914008936	4Fe-4S binding domain; Region: Fer4_5; pfam12801
224914008937	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
224914008938	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
224914008939	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
224914008940	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
224914008941	RES domain; Region: RES; cl02411
224914008942	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
224914008943	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
224914008944	N- and C-terminal domain interface [polypeptide binding]; other site
224914008945	putative active site [active]
224914008946	putative MgATP binding site [chemical binding]; other site
224914008947	catalytic site [active]
224914008948	metal binding site [ion binding]; metal-binding site
224914008949	carbohydrate binding site [chemical binding]; other site
224914008950	putative homodimer interface [polypeptide binding]; other site
224914008951	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224914008952	classical (c) SDRs; Region: SDR_c; cd05233
224914008953	NAD(P) binding site [chemical binding]; other site
224914008954	active site
224914008955	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224914008956	TM-ABC transporter signature motif; other site
224914008957	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
224914008958	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914008959	Walker A/P-loop; other site
224914008960	ATP binding site [chemical binding]; other site
224914008961	Q-loop/lid; other site
224914008962	ABC transporter signature motif; other site
224914008963	Walker B; other site
224914008964	D-loop; other site
224914008965	H-loop/switch region; other site
224914008966	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
224914008967	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
224914008968	putative ligand binding site [chemical binding]; other site
224914008969	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224914008970	Helix-turn-helix domains; Region: HTH; cl00088
224914008971	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
224914008972	dimerization interface [polypeptide binding]; other site
224914008973	ligand binding site [chemical binding]; other site
224914008974	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
224914008975	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224914008976	ligand binding site [chemical binding]; other site
224914008977	flexible hinge region; other site
224914008978	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
224914008979	putative switch regulator; other site
224914008980	non-specific DNA interactions [nucleotide binding]; other site
224914008981	DNA binding site [nucleotide binding]
224914008982	sequence specific DNA binding site [nucleotide binding]; other site
224914008983	putative cAMP binding site [chemical binding]; other site
224914008984	Uncharacterized conserved protein [Function unknown]; Region: COG1262
224914008985	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
224914008986	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
224914008987	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914008988	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
224914008989	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
224914008990	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
224914008991	nucleophilic elbow; other site
224914008992	catalytic triad; other site
224914008993	Phospholipid methyltransferase; Region: PEMT; cl00763
224914008994	Domain of unknown function DUF59; Region: DUF59; cl00941
224914008995	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
224914008996	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
224914008997	CPxP  motif; other site
224914008998	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
224914008999	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
224914009000	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
224914009001	metal ion-dependent adhesion site (MIDAS); other site
224914009002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224914009003	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
224914009004	Walker A motif; other site
224914009005	ATP binding site [chemical binding]; other site
224914009006	Walker B motif; other site
224914009007	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
224914009008	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
224914009009	D-pathway; other site
224914009010	K-pathway; other site
224914009011	Binuclear center (active site) [active]
224914009012	Putative proton exit pathway; other site
224914009013	Cytochrome c; Region: Cytochrom_C; cl11414
224914009014	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
224914009015	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
224914009016	Uncharacterized conserved protein [Function unknown]; Region: COG3945
224914009017	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
224914009018	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
224914009019	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
224914009020	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
224914009021	inhibitor site; inhibition site
224914009022	active site
224914009023	dimer interface [polypeptide binding]; other site
224914009024	catalytic residue [active]
224914009025	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224914009026	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914009027	DNA-binding site [nucleotide binding]; DNA binding site
224914009028	FCD domain; Region: FCD; cl11656
224914009029	EamA-like transporter family; Region: EamA; cl01037
224914009030	EamA-like transporter family; Region: EamA; cl01037
224914009031	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
224914009032	GAF domain; Region: GAF; cl15785
224914009033	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224914009034	metal binding site [ion binding]; metal-binding site
224914009035	active site
224914009036	I-site; other site
224914009037	ApbE family; Region: ApbE; cl00643
224914009038	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
224914009039	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
224914009040	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
224914009041	FAD binding pocket [chemical binding]; other site
224914009042	FAD binding motif [chemical binding]; other site
224914009043	catalytic residues [active]
224914009044	NAD binding pocket [chemical binding]; other site
224914009045	phosphate binding motif [ion binding]; other site
224914009046	beta-alpha-beta structure motif; other site
224914009047	Predicted periplasmic protein (DUF2271); Region: DUF2271; cl01469
224914009048	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
224914009049	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224914009050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224914009051	active site
224914009052	phosphorylation site [posttranslational modification]
224914009053	intermolecular recognition site; other site
224914009054	dimerization interface [polypeptide binding]; other site
224914009055	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224914009056	DNA binding site [nucleotide binding]
224914009057	sensor protein QseC; Provisional; Region: PRK10337
224914009058	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
224914009059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224914009060	dimer interface [polypeptide binding]; other site
224914009061	phosphorylation site [posttranslational modification]
224914009062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
224914009063	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
224914009064	potential catalytic triad [active]
224914009065	conserved cys residue [active]
224914009066	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786
224914009067	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224914009068	DNA binding residues [nucleotide binding]
224914009069	putative dimer interface [polypeptide binding]; other site
224914009070	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
224914009071	putative active site [active]
224914009072	putative FMN binding site [chemical binding]; other site
224914009073	putative substrate binding site [chemical binding]; other site
224914009074	putative catalytic residue [active]
224914009075	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
224914009076	CoA-transferase family III; Region: CoA_transf_3; pfam02515
224914009077	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
224914009078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
224914009079	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224914009080	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224914009081	enoyl-CoA hydratase; Provisional; Region: PRK08138
224914009082	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224914009083	substrate binding site [chemical binding]; other site
224914009084	oxyanion hole (OAH) forming residues; other site
224914009085	trimer interface [polypeptide binding]; other site
224914009086	Helix-turn-helix domains; Region: HTH; cl00088
224914009087	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224914009088	Bacterial transcriptional regulator; Region: IclR; pfam01614
224914009089	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224914009090	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
224914009091	active site
224914009092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914009093	putative substrate translocation pore; other site
224914009094	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
224914009095	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
224914009096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224914009097	ATP binding site [chemical binding]; other site
224914009098	Mg2+ binding site [ion binding]; other site
224914009099	G-X-G motif; other site
224914009100	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
224914009101	ATP binding site [chemical binding]; other site
224914009102	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
224914009103	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535
224914009104	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
224914009105	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
224914009106	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
224914009107	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
224914009108	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224914009109	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
224914009110	putative acyl-acceptor binding pocket; other site
224914009111	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
224914009112	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
224914009113	active site
224914009114	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
224914009115	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
224914009116	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
224914009117	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
224914009118	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914009119	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
224914009120	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
224914009121	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224914009122	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
224914009123	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224914009124	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224914009125	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
224914009126	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224914009127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224914009128	S-adenosylmethionine binding site [chemical binding]; other site
224914009129	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
224914009130	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224914009131	RNA binding surface [nucleotide binding]; other site
224914009132	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
224914009133	active site
224914009134	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
224914009135	nucleoside/Zn binding site; other site
224914009136	dimer interface [polypeptide binding]; other site
224914009137	catalytic motif [active]
224914009138	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
224914009139	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
224914009140	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224914009141	active site
224914009142	HIGH motif; other site
224914009143	nucleotide binding site [chemical binding]; other site
224914009144	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
224914009145	active site
224914009146	KMSKS motif; other site
224914009147	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
224914009148	tRNA binding surface [nucleotide binding]; other site
224914009149	anticodon binding site; other site
224914009150	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
224914009151	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
224914009152	active site
224914009153	Riboflavin kinase; Region: Flavokinase; cl03312
224914009154	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
224914009155	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224914009156	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
224914009157	oligomerisation interface [polypeptide binding]; other site
224914009158	mobile loop; other site
224914009159	roof hairpin; other site
224914009160	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
224914009161	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
224914009162	ring oligomerisation interface [polypeptide binding]; other site
224914009163	ATP/Mg binding site [chemical binding]; other site
224914009164	stacking interactions; other site
224914009165	hinge regions; other site
224914009166	fumarate hydratase; Reviewed; Region: fumC; PRK00485
224914009167	Class II fumarases; Region: Fumarase_classII; cd01362
224914009168	active site
224914009169	tetramer interface [polypeptide binding]; other site
224914009170	DoxX; Region: DoxX; cl00976
224914009171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914009172	putative substrate translocation pore; other site
224914009173	glucose/galactose transporter; Region: gluP; TIGR01272
224914009174	ATP phosphoribosyltransferase; Region: HisG; cl15266
224914009175	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
224914009176	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
224914009177	motif 1; other site
224914009178	dimer interface [polypeptide binding]; other site
224914009179	active site
224914009180	motif 2; other site
224914009181	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
224914009182	active site
224914009183	motif 3; other site
224914009184	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
224914009185	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
224914009186	dimer interface [polypeptide binding]; other site
224914009187	motif 1; other site
224914009188	motif 2; other site
224914009189	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
224914009190	active site
224914009191	motif 3; other site
224914009192	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
224914009193	anticodon binding site; other site
224914009194	LysE type translocator; Region: LysE; cl00565
224914009195	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
224914009196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
224914009197	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
224914009198	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224914009199	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
224914009200	active site
224914009201	catalytic tetrad [active]
224914009202	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
224914009203	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
224914009204	Cysteine-rich domain; Region: CCG; pfam02754
224914009205	Cysteine-rich domain; Region: CCG; pfam02754
224914009206	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
224914009207	FAD binding domain; Region: FAD_binding_4; pfam01565
224914009208	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
224914009209	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
224914009210	FAD binding domain; Region: FAD_binding_4; pfam01565
224914009211	Helix-turn-helix domains; Region: HTH; cl00088
224914009212	transcriptional activator TtdR; Provisional; Region: PRK09801
224914009213	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
224914009214	putative effector binding pocket; other site
224914009215	dimerization interface [polypeptide binding]; other site
224914009216	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
224914009217	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224914009218	DNA-binding site [nucleotide binding]; DNA binding site
224914009219	FCD domain; Region: FCD; cl11656
224914009220	Protein of unknown function (DUF465); Region: DUF465; cl01070
224914009221	Cytochrome c; Region: Cytochrom_C; cl11414
224914009222	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
224914009223	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
224914009224	Autotransporter beta-domain; Region: Autotransporter; cl02365
224914009225	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
224914009226	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
224914009227	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
224914009228	Uncharacterized conserved protein [Function unknown]; Region: COG3777
224914009229	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
224914009230	active site 2 [active]
224914009231	active site 1 [active]
224914009232	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
224914009233	CoA-transferase family III; Region: CoA_transf_3; pfam02515
224914009234	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224914009235	Helix-turn-helix domains; Region: HTH; cl00088
224914009236	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
224914009237	putative dimerization interface [polypeptide binding]; other site
224914009238	Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042
224914009239	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
224914009240	FliP family; Region: FliP; cl00593
224914009241	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
224914009242	Flagellar L-ring protein; Region: FlgH; cl00905
224914009243	MgtE intracellular N domain; Region: MgtE_N; cl15244
224914009244	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
224914009245	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
224914009246	SAF domain; Region: SAF; cl00555
224914009247	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
224914009248	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
224914009249	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
224914009250	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
224914009251	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
224914009252	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
224914009253	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
224914009254	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
224914009255	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
224914009256	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
224914009257	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
224914009258	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
224914009259	Metal-binding active site; metal-binding site
224914009260	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224914009261	Helix-turn-helix domains; Region: HTH; cl00088
224914009262	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
224914009263	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
224914009264	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
224914009265	putative NAD(P) binding site [chemical binding]; other site
224914009266	active site
224914009267	putative substrate binding site [chemical binding]; other site
224914009268	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
224914009269	intersubunit interface [polypeptide binding]; other site
224914009270	active site
224914009271	Zn2+ binding site [ion binding]; other site
224914009272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914009273	D-galactonate transporter; Region: 2A0114; TIGR00893
224914009274	putative substrate translocation pore; other site
224914009275	Helix-turn-helix domains; Region: HTH; cl00088
224914009276	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
224914009277	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224914009278	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224914009279	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364
224914009280	YdjC-like protein; Region: YdjC; cl01344
224914009281	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
224914009282	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
224914009283	Ligand binding site; other site
224914009284	Putative Catalytic site; other site
224914009285	DXD motif; other site
224914009286	Peptidase family M48; Region: Peptidase_M48; cl12018
224914009287	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
224914009288	active site
224914009289	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914009290	Walker A motif; other site
224914009291	ATP binding site [chemical binding]; other site
224914009292	Walker B motif; other site
224914009293	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
224914009294	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
224914009295	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
224914009296	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
224914009297	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
224914009298	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
224914009299	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
224914009300	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
224914009301	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
224914009302	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
224914009303	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
224914009304	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
224914009305	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
224914009306	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
224914009307	Autoinducer binding domain; Region: Autoind_bind; pfam03472
224914009308	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224914009309	DNA binding residues [nucleotide binding]
224914009310	dimerization interface [polypeptide binding]; other site
224914009311	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224914009312	Helix-turn-helix domains; Region: HTH; cl00088
224914009313	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
224914009314	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914009315	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
224914009316	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
224914009317	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224914009318	putative substrate translocation pore; other site
224914009319	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
224914009320	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224914009321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914009322	dimer interface [polypeptide binding]; other site
224914009323	conserved gate region; other site
224914009324	putative PBP binding loops; other site
224914009325	ABC-ATPase subunit interface; other site
224914009326	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
224914009327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224914009328	dimer interface [polypeptide binding]; other site
224914009329	conserved gate region; other site
224914009330	putative PBP binding loops; other site
224914009331	ABC-ATPase subunit interface; other site
224914009332	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
224914009333	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
224914009334	Walker A/P-loop; other site
224914009335	ATP binding site [chemical binding]; other site
224914009336	Q-loop/lid; other site
224914009337	ABC transporter signature motif; other site
224914009338	Walker B; other site
224914009339	D-loop; other site
224914009340	H-loop/switch region; other site
224914009341	TOBE domain; Region: TOBE_2; cl01440
224914009342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914009343	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
224914009344	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
224914009345	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914009346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914009347	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
224914009348	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224914009349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224914009350	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
224914009351	O-Antigen ligase; Region: Wzy_C; cl04850
224914009352	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
224914009353	active site
224914009354	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
224914009355	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
224914009356	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
224914009357	Chain length determinant protein; Region: Wzz; cl01623
224914009358	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
224914009359	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
224914009360	dimer interface [polypeptide binding]; other site
224914009361	active site
224914009362	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224914009363	catalytic residues [active]
224914009364	substrate binding site [chemical binding]; other site
224914009365	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
224914009366	Helix-turn-helix domains; Region: HTH; cl00088
224914009367	LysR family transcriptional regulator; Provisional; Region: PRK14997
224914009368	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
224914009369	putative effector binding pocket; other site
224914009370	dimerization interface [polypeptide binding]; other site
224914009371	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
224914009372	High-affinity nickel-transport protein; Region: NicO; cl00964