-- dump date 20140619_011847 -- class Genbank::misc_feature -- table misc_feature_note -- id note 224915000001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 224915000002 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 224915000003 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 224915000004 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 224915000005 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 224915000006 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 224915000007 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 224915000008 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 224915000009 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 224915000010 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 224915000011 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 224915000012 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 224915000013 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 224915000014 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 224915000015 beta subunit interaction interface [polypeptide binding]; other site 224915000016 Walker A motif; other site 224915000017 ATP binding site [chemical binding]; other site 224915000018 Walker B motif; other site 224915000019 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 224915000020 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 224915000021 core domain interface [polypeptide binding]; other site 224915000022 delta subunit interface [polypeptide binding]; other site 224915000023 epsilon subunit interface [polypeptide binding]; other site 224915000024 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 224915000025 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 224915000026 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 224915000027 alpha subunit interaction interface [polypeptide binding]; other site 224915000028 Walker A motif; other site 224915000029 ATP binding site [chemical binding]; other site 224915000030 Walker B motif; other site 224915000031 inhibitor binding site; inhibition site 224915000032 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 224915000033 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 224915000034 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 224915000035 gamma subunit interface [polypeptide binding]; other site 224915000036 epsilon subunit interface [polypeptide binding]; other site 224915000037 LBP interface [polypeptide binding]; other site 224915000038 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 224915000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 224915000040 Mg2+ binding site [ion binding]; other site 224915000041 G-X-G motif; other site 224915000042 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 224915000043 anchoring element; other site 224915000044 dimer interface [polypeptide binding]; other site 224915000045 ATP binding site [chemical binding]; other site 224915000046 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 224915000047 active site 224915000048 putative metal-binding site [ion binding]; other site 224915000049 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 224915000050 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 224915000051 DNA polymerase III subunit beta; Validated; Region: PRK05643 224915000052 putative DNA binding surface [nucleotide binding]; other site 224915000053 dimer interface [polypeptide binding]; other site 224915000054 beta-clamp/clamp loader binding surface; other site 224915000055 beta-clamp/translesion DNA polymerase binding surface; other site 224915000056 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 224915000057 DnaA N-terminal domain; Region: DnaA_N; pfam11638 224915000058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224915000059 Walker A motif; other site 224915000060 ATP binding site [chemical binding]; other site 224915000061 Walker B motif; other site 224915000062 arginine finger; other site 224915000063 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 224915000064 DnaA box-binding interface [nucleotide binding]; other site 224915000065 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 224915000066 Ribonuclease P; Region: Ribonuclease_P; cl00457 224915000067 Haemolytic domain; Region: Haemolytic; pfam01809 224915000068 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 224915000069 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 224915000070 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 224915000071 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 224915000072 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 224915000073 trmE is a tRNA modification GTPase; Region: trmE; cd04164 224915000074 G1 box; other site 224915000075 GTP/Mg2+ binding site [chemical binding]; other site 224915000076 Switch I region; other site 224915000077 G2 box; other site 224915000078 Switch II region; other site 224915000079 G3 box; other site 224915000080 G4 box; other site 224915000081 G5 box; other site 224915000082 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 224915000083 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 224915000084 putative DNA-binding cleft [nucleotide binding]; other site 224915000085 putative DNA clevage site; other site 224915000086 molecular lever; other site 224915000087 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 224915000088 oligomerisation interface [polypeptide binding]; other site 224915000089 mobile loop; other site 224915000090 roof hairpin; other site 224915000091 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 224915000092 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 224915000093 ring oligomerisation interface [polypeptide binding]; other site 224915000094 ATP/Mg binding site [chemical binding]; other site 224915000095 stacking interactions; other site 224915000096 hinge regions; other site 224915000097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 224915000098 Radical SAM superfamily; Region: Radical_SAM; pfam04055 224915000099 translation elongation factor P; Region: efp; TIGR00038 224915000100 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 224915000101 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 224915000102 RNA binding site [nucleotide binding]; other site 224915000103 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 224915000104 RNA binding site [nucleotide binding]; other site 224915000105 DNA replication protein DnaC; Validated; Region: PRK07952 224915000106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224915000107 Walker A motif; other site 224915000108 ATP binding site [chemical binding]; other site 224915000109 Walker B motif; other site 224915000110 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 224915000111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 224915000112 S-adenosylmethionine binding site [chemical binding]; other site 224915000113 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 224915000114 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 224915000115 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 224915000116 P loop; other site 224915000117 GTP binding site [chemical binding]; other site 224915000118 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 224915000119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 224915000120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 224915000121 DNA binding residues [nucleotide binding] 224915000122 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 224915000123 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 224915000124 glutaminase active site [active] 224915000125 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 224915000126 dimer interface [polypeptide binding]; other site 224915000127 active site 224915000128 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 224915000129 dimer interface [polypeptide binding]; other site 224915000130 active site 224915000131 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 224915000132 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 224915000133 Substrate binding site; other site 224915000134 Mg++ binding site; other site 224915000135 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 224915000136 active site 224915000137 substrate binding site [chemical binding]; other site 224915000138 CoA binding site [chemical binding]; other site 224915000139 putative hydrolase; Provisional; Region: PRK10976 224915000140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 224915000141 active site 224915000142 motif I; other site 224915000143 motif II; other site 224915000144 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 224915000145 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 224915000146 THF binding site; other site 224915000147 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 224915000148 substrate binding site [chemical binding]; other site 224915000149 THF binding site; other site 224915000150 zinc-binding site [ion binding]; other site 224915000151 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 224915000152 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 224915000153 purine monophosphate binding site [chemical binding]; other site 224915000154 dimer interface [polypeptide binding]; other site 224915000155 putative catalytic residues [active] 224915000156 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 224915000157 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 224915000158 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 224915000159 IHF dimer interface [polypeptide binding]; other site 224915000160 IHF - DNA interface [nucleotide binding]; other site 224915000161 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 224915000162 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 224915000163 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 224915000164 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 224915000165 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 224915000166 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 224915000167 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 224915000168 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 224915000169 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 224915000170 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 224915000171 DNA binding site [nucleotide binding] 224915000172 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 224915000173 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 224915000174 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 224915000175 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 224915000176 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 224915000177 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 224915000178 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 224915000179 RPB3 interaction site [polypeptide binding]; other site 224915000180 RPB1 interaction site [polypeptide binding]; other site 224915000181 RPB11 interaction site [polypeptide binding]; other site 224915000182 RPB10 interaction site [polypeptide binding]; other site 224915000183 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 224915000184 core dimer interface [polypeptide binding]; other site 224915000185 peripheral dimer interface [polypeptide binding]; other site 224915000186 L10 interface [polypeptide binding]; other site 224915000187 L11 interface [polypeptide binding]; other site 224915000188 putative EF-Tu interaction site [polypeptide binding]; other site 224915000189 putative EF-G interaction site [polypeptide binding]; other site 224915000190 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 224915000191 23S rRNA interface [nucleotide binding]; other site 224915000192 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 224915000193 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 224915000194 mRNA/rRNA interface [nucleotide binding]; other site 224915000195 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 224915000196 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 224915000197 23S rRNA interface [nucleotide binding]; other site 224915000198 L7/L12 interface [polypeptide binding]; other site 224915000199 putative thiostrepton binding site; other site 224915000200 L25 interface [polypeptide binding]; other site 224915000201 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 224915000202 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 224915000203 putative homodimer interface [polypeptide binding]; other site 224915000204 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 224915000205 heterodimer interface [polypeptide binding]; other site 224915000206 homodimer interface [polypeptide binding]; other site 224915000207 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 224915000208 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 224915000209 FAD binding domain; Region: FAD_binding_4; pfam01565 224915000210 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 224915000211 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 224915000212 FAD binding site [chemical binding]; other site 224915000213 argininosuccinate synthase; Provisional; Region: PRK13820 224915000214 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 224915000215 ANP binding site [chemical binding]; other site 224915000216 Substrate Binding Site II [chemical binding]; other site 224915000217 Substrate Binding Site I [chemical binding]; other site 224915000218 argininosuccinate lyase; Provisional; Region: PRK04833 224915000219 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 224915000220 active sites [active] 224915000221 tetramer interface [polypeptide binding]; other site 224915000222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 224915000223 active site residue [active] 224915000224 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 224915000225 serine O-acetyltransferase; Region: cysE; TIGR01172 224915000226 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 224915000227 trimer interface [polypeptide binding]; other site 224915000228 active site 224915000229 substrate binding site [chemical binding]; other site 224915000230 CoA binding site [chemical binding]; other site 224915000231 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 224915000232 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 224915000233 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 224915000234 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 224915000235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 224915000236 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 224915000237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 224915000238 DNA binding residues [nucleotide binding] 224915000239 DNA primase; Validated; Region: dnaG; PRK05667 224915000240 CHC2 zinc finger; Region: zf-CHC2; pfam01807 224915000241 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 224915000242 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 224915000243 active site 224915000244 metal binding site [ion binding]; metal-binding site 224915000245 interdomain interaction site; other site 224915000246 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 224915000247 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 224915000248 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 224915000249 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 224915000250 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 224915000251 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 224915000252 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 224915000253 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13298 224915000254 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 224915000255 active site 224915000256 NTP binding site [chemical binding]; other site 224915000257 metal binding triad [ion binding]; metal-binding site 224915000258 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 224915000259 Bacitracin resistance protein BacA; Region: BacA; pfam02673 224915000260 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 224915000261 HPr interaction site; other site 224915000262 glycerol kinase (GK) interaction site [polypeptide binding]; other site 224915000263 active site 224915000264 phosphorylation site [posttranslational modification] 224915000265 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 224915000266 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 224915000267 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 224915000268 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 224915000269 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 224915000270 dimerization domain swap beta strand [polypeptide binding]; other site 224915000271 regulatory protein interface [polypeptide binding]; other site 224915000272 active site 224915000273 regulatory phosphorylation site [posttranslational modification]; other site 224915000274 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 224915000275 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 224915000276 nucleotide binding pocket [chemical binding]; other site 224915000277 K-X-D-G motif; other site 224915000278 catalytic site [active] 224915000279 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 224915000280 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 224915000281 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 224915000282 HIGH motif; other site 224915000283 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 224915000284 active site 224915000285 KMSKS motif; other site 224915000286 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 224915000287 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 224915000288 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 224915000289 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 224915000290 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 224915000291 FliG C-terminal domain; Region: FliG_C; pfam01706 224915000292 Flagellar assembly protein FliH; Region: FliH; pfam02108 224915000293 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 224915000294 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 224915000295 Walker A motif; other site 224915000296 ATP binding site [chemical binding]; other site 224915000297 Walker B motif; other site 224915000298 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 224915000299 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 224915000300 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 224915000301 flagellar motor switch protein FliN; Region: fliN; TIGR02480 224915000302 putative bifunctional flagellar biosynthesis protein FliO/FliP; Provisional; Region: PRK12430 224915000303 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 224915000304 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 224915000305 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 224915000306 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 224915000307 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 224915000308 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 224915000309 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 224915000310 dimer interface [polypeptide binding]; other site 224915000311 substrate binding site [chemical binding]; other site 224915000312 metal binding sites [ion binding]; metal-binding site 224915000313 peptidase PmbA; Provisional; Region: PRK11040 224915000314 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 224915000315 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 224915000316 putative SAM binding site [chemical binding]; other site 224915000317 putative homodimer interface [polypeptide binding]; other site 224915000318 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 224915000319 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 224915000320 dimer interface [polypeptide binding]; other site 224915000321 active site 224915000322 transaldolase-like protein; Provisional; Region: PTZ00411 224915000323 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 224915000324 active site 224915000325 dimer interface [polypeptide binding]; other site 224915000326 catalytic residue [active] 224915000327 transketolase; Reviewed; Region: PRK12753 224915000328 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 224915000329 TPP-binding site [chemical binding]; other site 224915000330 dimer interface [polypeptide binding]; other site 224915000331 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 224915000332 PYR/PP interface [polypeptide binding]; other site 224915000333 dimer interface [polypeptide binding]; other site 224915000334 TPP binding site [chemical binding]; other site 224915000335 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 224915000336 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 224915000337 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 224915000338 metal binding site [ion binding]; metal-binding site 224915000339 dimer interface [polypeptide binding]; other site 224915000340 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 224915000341 dihydrodipicolinate synthase; Region: dapA; TIGR00674 224915000342 dimer interface [polypeptide binding]; other site 224915000343 active site 224915000344 catalytic residue [active] 224915000345 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 224915000346 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 224915000347 Tetramer interface [polypeptide binding]; other site 224915000348 active site 224915000349 FMN-binding site [chemical binding]; other site 224915000350 hypothetical protein; Provisional; Region: PRK04946 224915000351 Smr domain; Region: Smr; pfam01713 224915000352 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 224915000353 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 224915000354 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 224915000355 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 224915000356 histidinol dehydrogenase; Region: hisD; TIGR00069 224915000357 NAD binding site [chemical binding]; other site 224915000358 dimerization interface [polypeptide binding]; other site 224915000359 product binding site; other site 224915000360 substrate binding site [chemical binding]; other site 224915000361 zinc binding site [ion binding]; other site 224915000362 catalytic residues [active] 224915000363 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 224915000364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 224915000365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 224915000366 homodimer interface [polypeptide binding]; other site 224915000367 catalytic residue [active] 224915000368 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 224915000369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 224915000370 active site 224915000371 motif I; other site 224915000372 motif II; other site 224915000373 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 224915000374 putative active site pocket [active] 224915000375 4-fold oligomerization interface [polypeptide binding]; other site 224915000376 metal binding residues [ion binding]; metal-binding site 224915000377 3-fold/trimer interface [polypeptide binding]; other site 224915000378 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 224915000379 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 224915000380 putative active site [active] 224915000381 oxyanion strand; other site 224915000382 catalytic triad [active] 224915000383 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 224915000384 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 224915000385 catalytic residues [active] 224915000386 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 224915000387 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 224915000388 substrate binding site [chemical binding]; other site 224915000389 glutamase interaction surface [polypeptide binding]; other site 224915000390 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 224915000391 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 224915000392 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 224915000393 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 224915000394 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 224915000395 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 224915000396 trimer interface [polypeptide binding]; other site 224915000397 active site 224915000398 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 224915000399 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224915000400 active site 224915000401 nucleotide binding site [chemical binding]; other site 224915000402 HIGH motif; other site 224915000403 KMSKS motif; other site 224915000404 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 224915000405 tRNA binding surface [nucleotide binding]; other site 224915000406 anticodon binding site; other site 224915000407 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 224915000408 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 224915000409 Ligand Binding Site [chemical binding]; other site 224915000410 TilS substrate binding domain; Region: TilS; pfam09179 224915000411 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 224915000412 multidrug efflux protein; Reviewed; Region: PRK01766 224915000413 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 224915000414 cation binding site [ion binding]; other site 224915000415 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 224915000416 Lumazine binding domain; Region: Lum_binding; pfam00677 224915000417 Lumazine binding domain; Region: Lum_binding; pfam00677 224915000418 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 224915000419 ferredoxin; Provisional; Region: PRK08764 224915000420 Putative Fe-S cluster; Region: FeS; cl17515 224915000421 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 224915000422 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 224915000423 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 224915000424 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 224915000425 FMN-binding domain; Region: FMN_bind; cl01081 224915000426 electron transport complex RsxE subunit; Provisional; Region: PRK12405 224915000427 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 224915000428 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 224915000429 minor groove reading motif; other site 224915000430 helix-hairpin-helix signature motif; other site 224915000431 substrate binding pocket [chemical binding]; other site 224915000432 active site 224915000433 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 224915000434 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 224915000435 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 224915000436 active site 224915000437 HIGH motif; other site 224915000438 dimer interface [polypeptide binding]; other site 224915000439 KMSKS motif; other site 224915000440 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 224915000441 putative inner membrane protein; Provisional; Region: PRK10983 224915000442 Domain of unknown function DUF20; Region: UPF0118; pfam01594 224915000443 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 224915000444 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 224915000445 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 224915000446 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 224915000447 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 224915000448 active site 224915000449 dimer interface [polypeptide binding]; other site 224915000450 motif 1; other site 224915000451 motif 2; other site 224915000452 motif 3; other site 224915000453 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 224915000454 anticodon binding site; other site 224915000455 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 224915000456 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 224915000457 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 224915000458 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 224915000459 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 224915000460 23S rRNA binding site [nucleotide binding]; other site 224915000461 L21 binding site [polypeptide binding]; other site 224915000462 L13 binding site [polypeptide binding]; other site 224915000463 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 224915000464 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 224915000465 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 224915000466 dimer interface [polypeptide binding]; other site 224915000467 motif 1; other site 224915000468 active site 224915000469 motif 2; other site 224915000470 motif 3; other site 224915000471 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 224915000472 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 224915000473 putative tRNA-binding site [nucleotide binding]; other site 224915000474 B3/4 domain; Region: B3_4; pfam03483 224915000475 tRNA synthetase B5 domain; Region: B5; smart00874 224915000476 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 224915000477 dimer interface [polypeptide binding]; other site 224915000478 motif 1; other site 224915000479 motif 3; other site 224915000480 motif 2; other site 224915000481 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 224915000482 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 224915000483 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 224915000484 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 224915000485 dimer interface [polypeptide binding]; other site 224915000486 motif 1; other site 224915000487 active site 224915000488 motif 2; other site 224915000489 motif 3; other site 224915000490 endonuclease IV; Provisional; Region: PRK01060 224915000491 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 224915000492 AP (apurinic/apyrimidinic) site pocket; other site 224915000493 DNA interaction; other site 224915000494 Metal-binding active site; metal-binding site 224915000495 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 224915000496 5S rRNA interface [nucleotide binding]; other site 224915000497 CTC domain interface [polypeptide binding]; other site 224915000498 L16 interface [polypeptide binding]; other site 224915000499 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 224915000500 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 224915000501 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 224915000502 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 224915000503 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 224915000504 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 224915000505 active site 224915000506 metal binding site [ion binding]; metal-binding site 224915000507 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 224915000508 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 224915000509 folate binding site [chemical binding]; other site 224915000510 NADP+ binding site [chemical binding]; other site 224915000511 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 224915000512 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 224915000513 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 224915000514 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 224915000515 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 224915000516 ATP-grasp domain; Region: ATP-grasp_4; cl17255 224915000517 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 224915000518 IMP binding site; other site 224915000519 dimer interface [polypeptide binding]; other site 224915000520 interdomain contacts; other site 224915000521 partial ornithine binding site; other site 224915000522 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 224915000523 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 224915000524 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 224915000525 catalytic site [active] 224915000526 subunit interface [polypeptide binding]; other site 224915000527 dihydrodipicolinate reductase; Provisional; Region: PRK00048 224915000528 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 224915000529 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 224915000530 LytB protein; Region: LYTB; cl00507 224915000531 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 224915000532 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 224915000533 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224915000534 active site 224915000535 HIGH motif; other site 224915000536 nucleotide binding site [chemical binding]; other site 224915000537 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 224915000538 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 224915000539 active site 224915000540 KMSKS motif; other site 224915000541 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 224915000542 tRNA binding surface [nucleotide binding]; other site 224915000543 anticodon binding site; other site 224915000544 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 224915000545 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 224915000546 chaperone protein DnaJ; Provisional; Region: PRK10767 224915000547 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 224915000548 HSP70 interaction site [polypeptide binding]; other site 224915000549 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 224915000550 substrate binding site [polypeptide binding]; other site 224915000551 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 224915000552 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 224915000553 dimer interface [polypeptide binding]; other site 224915000554 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 224915000555 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 224915000556 nucleotide binding site [chemical binding]; other site 224915000557 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 224915000558 NADH dehydrogenase subunit B; Validated; Region: PRK06411 224915000559 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 224915000560 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 224915000561 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 224915000562 NADH dehydrogenase subunit E; Validated; Region: PRK07539 224915000563 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 224915000564 putative dimer interface [polypeptide binding]; other site 224915000565 [2Fe-2S] cluster binding site [ion binding]; other site 224915000566 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 224915000567 SLBB domain; Region: SLBB; pfam10531 224915000568 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 224915000569 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 224915000570 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 224915000571 catalytic loop [active] 224915000572 iron binding site [ion binding]; other site 224915000573 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 224915000574 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 224915000575 [4Fe-4S] binding site [ion binding]; other site 224915000576 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 224915000577 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 224915000578 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 224915000579 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 224915000580 4Fe-4S binding domain; Region: Fer4; cl02805 224915000581 4Fe-4S binding domain; Region: Fer4; pfam00037 224915000582 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 224915000583 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 224915000584 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 224915000585 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 224915000586 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 224915000587 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00204 224915000588 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 224915000589 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 224915000590 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 224915000591 Integral membrane protein TerC family; Region: TerC; cl10468 224915000592 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 224915000593 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224915000594 Colicin V production protein; Region: Colicin_V; cl00567 224915000595 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 224915000596 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 224915000597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 224915000598 active site 224915000599 peptide chain release factor 1; Validated; Region: prfA; PRK00591 224915000600 This domain is found in peptide chain release factors; Region: PCRF; smart00937 224915000601 RF-1 domain; Region: RF-1; pfam00472 224915000602 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 224915000603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 224915000604 S-adenosylmethionine binding site [chemical binding]; other site 224915000605 hypothetical protein; Provisional; Region: PRK10941 224915000606 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 224915000607 Acetokinase family; Region: Acetate_kinase; cl17229 224915000608 propionate/acetate kinase; Provisional; Region: PRK12379 224915000609 phosphate acetyltransferase; Reviewed; Region: PRK05632 224915000610 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 224915000611 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 224915000612 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 224915000613 catalytic loop [active] 224915000614 iron binding site [ion binding]; other site 224915000615 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 224915000616 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 224915000617 dimer interface [polypeptide binding]; other site 224915000618 putative radical transfer pathway; other site 224915000619 diiron center [ion binding]; other site 224915000620 tyrosyl radical; other site 224915000621 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 224915000622 ATP cone domain; Region: ATP-cone; pfam03477 224915000623 Class I ribonucleotide reductase; Region: RNR_I; cd01679 224915000624 active site 224915000625 dimer interface [polypeptide binding]; other site 224915000626 catalytic residues [active] 224915000627 effector binding site; other site 224915000628 R2 peptide binding site; other site 224915000629 DNA gyrase subunit A; Validated; Region: PRK05560 224915000630 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 224915000631 CAP-like domain; other site 224915000632 active site 224915000633 primary dimer interface [polypeptide binding]; other site 224915000634 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224915000635 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224915000636 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224915000637 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224915000638 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224915000639 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 224915000640 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 224915000641 peroxidase; Provisional; Region: PRK15000 224915000642 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 224915000643 dimer interface [polypeptide binding]; other site 224915000644 decamer (pentamer of dimers) interface [polypeptide binding]; other site 224915000645 catalytic triad [active] 224915000646 peroxidatic and resolving cysteines [active] 224915000647 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 224915000648 ligand binding site [chemical binding]; other site 224915000649 active site 224915000650 UGI interface [polypeptide binding]; other site 224915000651 catalytic site [active] 224915000652 GrpE; Region: GrpE; pfam01025 224915000653 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 224915000654 dimer interface [polypeptide binding]; other site 224915000655 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 224915000656 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 224915000657 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 224915000658 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 224915000659 putative GSH binding site [chemical binding]; other site 224915000660 catalytic residues [active] 224915000661 ribonuclease T; Provisional; Region: PRK05168 224915000662 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 224915000663 active site 224915000664 catalytic site [active] 224915000665 substrate binding site [chemical binding]; other site 224915000666 superoxide dismutase; Provisional; Region: PRK10925 224915000667 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 224915000668 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 224915000669 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 224915000670 putative active site [active] 224915000671 catalytic residue [active] 224915000672 GTP-binding protein YchF; Reviewed; Region: PRK09601 224915000673 YchF GTPase; Region: YchF; cd01900 224915000674 G1 box; other site 224915000675 GTP/Mg2+ binding site [chemical binding]; other site 224915000676 Switch I region; other site 224915000677 G2 box; other site 224915000678 Switch II region; other site 224915000679 G3 box; other site 224915000680 G4 box; other site 224915000681 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 224915000682 threonine synthase; Validated; Region: PRK09225 224915000683 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 224915000684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 224915000685 catalytic residue [active] 224915000686 homoserine kinase; Provisional; Region: PRK01212 224915000687 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 224915000688 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 224915000689 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 224915000690 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 224915000691 putative catalytic residues [active] 224915000692 putative nucleotide binding site [chemical binding]; other site 224915000693 putative aspartate binding site [chemical binding]; other site 224915000694 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 224915000695 dimer interface [polypeptide binding]; other site 224915000696 putative threonine allosteric regulatory site; other site 224915000697 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 224915000698 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 224915000699 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 224915000700 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 224915000701 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 224915000702 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 224915000703 dimerization interface 3.5A [polypeptide binding]; other site 224915000704 active site 224915000705 penicillin-binding protein 1b; Provisional; Region: PRK14850 224915000706 Transglycosylase; Region: Transgly; pfam00912 224915000707 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 224915000708 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 224915000709 DEAD/DEAH box helicase; Region: DEAD; pfam00270 224915000710 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 224915000711 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 224915000712 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 224915000713 active site 224915000714 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 224915000715 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 224915000716 dimer interface [polypeptide binding]; other site 224915000717 TPP-binding site [chemical binding]; other site 224915000718 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 224915000719 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 224915000720 E3 interaction surface; other site 224915000721 lipoyl attachment site [posttranslational modification]; other site 224915000722 e3 binding domain; Region: E3_binding; pfam02817 224915000723 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 224915000724 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 224915000725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 224915000726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 224915000727 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 224915000728 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 224915000729 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 224915000730 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 224915000731 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 224915000732 cell division protein FtsZ; Validated; Region: PRK09330 224915000733 nucleotide binding site [chemical binding]; other site 224915000734 SulA interaction site; other site 224915000735 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 224915000736 Cell division protein FtsA; Region: FtsA; smart00842 224915000737 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 224915000738 Cell division protein FtsA; Region: FtsA; pfam14450 224915000739 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 224915000740 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 224915000741 ATP-grasp domain; Region: ATP-grasp_4; cl17255 224915000742 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 224915000743 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 224915000744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 224915000745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224915000746 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 224915000747 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 224915000748 active site 224915000749 homodimer interface [polypeptide binding]; other site 224915000750 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 224915000751 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 224915000752 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 224915000753 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224915000754 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 224915000755 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 224915000756 Mg++ binding site [ion binding]; other site 224915000757 putative catalytic motif [active] 224915000758 putative substrate binding site [chemical binding]; other site 224915000759 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 224915000760 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 224915000761 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 224915000762 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224915000763 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 224915000764 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 224915000765 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 224915000766 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 224915000767 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 224915000768 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 224915000769 Cell division protein FtsL; Region: FtsL; cl11433 224915000770 MraW methylase family; Region: Methyltransf_5; cl17771 224915000771 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 224915000772 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 224915000773 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 224915000774 putative valine binding site [chemical binding]; other site 224915000775 dimer interface [polypeptide binding]; other site 224915000776 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 224915000777 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 224915000778 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 224915000779 PYR/PP interface [polypeptide binding]; other site 224915000780 dimer interface [polypeptide binding]; other site 224915000781 TPP binding site [chemical binding]; other site 224915000782 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 224915000783 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 224915000784 TPP-binding site [chemical binding]; other site 224915000785 dimer interface [polypeptide binding]; other site 224915000786 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 224915000787 ApbE family; Region: ApbE; pfam02424 224915000788 serine endoprotease; Provisional; Region: PRK10942 224915000789 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 224915000790 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 224915000791 protein binding site [polypeptide binding]; other site 224915000792 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 224915000793 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 224915000794 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 224915000795 trimer interface [polypeptide binding]; other site 224915000796 active site 224915000797 substrate binding site [chemical binding]; other site 224915000798 CoA binding site [chemical binding]; other site 224915000799 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 224915000800 active site 224915000801 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 224915000802 rRNA interaction site [nucleotide binding]; other site 224915000803 S8 interaction site; other site 224915000804 putative laminin-1 binding site; other site 224915000805 elongation factor Ts; Provisional; Region: tsf; PRK09377 224915000806 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 224915000807 Elongation factor TS; Region: EF_TS; pfam00889 224915000808 Elongation factor TS; Region: EF_TS; pfam00889 224915000809 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 224915000810 putative nucleotide binding site [chemical binding]; other site 224915000811 uridine monophosphate binding site [chemical binding]; other site 224915000812 homohexameric interface [polypeptide binding]; other site 224915000813 ribosome recycling factor; Reviewed; Region: frr; PRK00083 224915000814 Ribosome recycling factor; Region: RRF; pfam01765 224915000815 hinge region; other site 224915000816 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 224915000817 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 224915000818 catalytic residue [active] 224915000819 putative FPP diphosphate binding site; other site 224915000820 putative FPP binding hydrophobic cleft; other site 224915000821 dimer interface [polypeptide binding]; other site 224915000822 putative IPP diphosphate binding site; other site 224915000823 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 224915000824 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 224915000825 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 224915000826 putative active site [active] 224915000827 putative PHP Thumb interface [polypeptide binding]; other site 224915000828 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 224915000829 generic binding surface I; other site 224915000830 generic binding surface II; other site 224915000831 prolyl-tRNA synthetase; Provisional; Region: PRK09194 224915000832 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 224915000833 dimer interface [polypeptide binding]; other site 224915000834 motif 1; other site 224915000835 active site 224915000836 motif 2; other site 224915000837 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 224915000838 putative deacylase active site [active] 224915000839 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 224915000840 active site 224915000841 motif 3; other site 224915000842 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 224915000843 anticodon binding site; other site 224915000844 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 224915000845 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 224915000846 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 224915000847 FHIPEP family; Region: FHIPEP; pfam00771 224915000848 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 224915000849 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 224915000850 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 224915000851 active site 224915000852 HIGH motif; other site 224915000853 KMSK motif region; other site 224915000854 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 224915000855 tRNA binding surface [nucleotide binding]; other site 224915000856 anticodon binding site; other site 224915000857 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 224915000858 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 224915000859 RNA/DNA hybrid binding site [nucleotide binding]; other site 224915000860 active site 224915000861 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 224915000862 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 224915000863 active site 224915000864 catalytic site [active] 224915000865 substrate binding site [chemical binding]; other site 224915000866 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 224915000867 active site 224915000868 GrpE; Region: GrpE; pfam01025 224915000869 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 224915000870 dimer interface [polypeptide binding]; other site 224915000871 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 224915000872 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 224915000873 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 224915000874 SmpB-tmRNA interface; other site 224915000875 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 224915000876 nucleoside/Zn binding site; other site 224915000877 dimer interface [polypeptide binding]; other site 224915000878 catalytic motif [active] 224915000879 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 224915000880 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 224915000881 GTPase Era; Reviewed; Region: era; PRK00089 224915000882 G1 box; other site 224915000883 GTP/Mg2+ binding site [chemical binding]; other site 224915000884 Switch I region; other site 224915000885 G2 box; other site 224915000886 Switch II region; other site 224915000887 G3 box; other site 224915000888 G4 box; other site 224915000889 G5 box; other site 224915000890 ribonuclease III; Reviewed; Region: rnc; PRK00102 224915000891 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 224915000892 dimerization interface [polypeptide binding]; other site 224915000893 active site 224915000894 metal binding site [ion binding]; metal-binding site 224915000895 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 224915000896 dsRNA binding site [nucleotide binding]; other site 224915000897 signal peptidase I; Provisional; Region: PRK10861 224915000898 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 224915000899 Catalytic site [active] 224915000900 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 224915000901 GTP-binding protein LepA; Provisional; Region: PRK05433 224915000902 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 224915000903 G1 box; other site 224915000904 putative GEF interaction site [polypeptide binding]; other site 224915000905 GTP/Mg2+ binding site [chemical binding]; other site 224915000906 Switch I region; other site 224915000907 G2 box; other site 224915000908 G3 box; other site 224915000909 Switch II region; other site 224915000910 G4 box; other site 224915000911 G5 box; other site 224915000912 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 224915000913 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 224915000914 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 224915000915 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 224915000916 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 224915000917 Ligand Binding Site [chemical binding]; other site 224915000918 putative lysogenization regulator; Reviewed; Region: PRK00218 224915000919 adenylosuccinate lyase; Provisional; Region: PRK09285 224915000920 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 224915000921 tetramer interface [polypeptide binding]; other site 224915000922 active site 224915000923 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 224915000924 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 224915000925 N-acetyl-D-glucosamine binding site [chemical binding]; other site 224915000926 catalytic residue [active] 224915000927 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 224915000928 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 224915000929 NAD binding site [chemical binding]; other site 224915000930 homotetramer interface [polypeptide binding]; other site 224915000931 homodimer interface [polypeptide binding]; other site 224915000932 substrate binding site [chemical binding]; other site 224915000933 active site 224915000934 exoribonuclease II; Provisional; Region: PRK05054 224915000935 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 224915000936 RNB domain; Region: RNB; pfam00773 224915000937 hypothetical protein; Provisional; Region: PRK11111 224915000938 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 224915000939 lipoyl synthase; Provisional; Region: PRK05481 224915000940 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 224915000941 active site 224915000942 dimer interface [polypeptide binding]; other site 224915000943 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 224915000944 dimerization interface [polypeptide binding]; other site 224915000945 active site 224915000946 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 224915000947 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 224915000948 putative active site [active] 224915000949 catalytic site [active] 224915000950 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 224915000951 putative active site [active] 224915000952 catalytic site [active] 224915000953 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 224915000954 Intracellular septation protein A; Region: IspA; pfam04279 224915000955 hypothetical protein; Provisional; Region: PRK02868 224915000956 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 224915000957 substrate binding site [chemical binding]; other site 224915000958 active site 224915000959 catalytic residues [active] 224915000960 heterodimer interface [polypeptide binding]; other site 224915000961 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 224915000962 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 224915000963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 224915000964 catalytic residue [active] 224915000965 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 224915000966 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 224915000967 active site 224915000968 ribulose/triose binding site [chemical binding]; other site 224915000969 phosphate binding site [ion binding]; other site 224915000970 substrate (anthranilate) binding pocket [chemical binding]; other site 224915000971 product (indole) binding pocket [chemical binding]; other site 224915000972 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 224915000973 active site 224915000974 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 224915000975 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 224915000976 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 224915000977 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 224915000978 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 224915000979 probable active site [active] 224915000980 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 224915000981 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 224915000982 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 224915000983 tandem repeat interface [polypeptide binding]; other site 224915000984 oligomer interface [polypeptide binding]; other site 224915000985 active site residues [active] 224915000986 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 224915000987 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 224915000988 active site 224915000989 dimerization interface [polypeptide binding]; other site 224915000990 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 224915000991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 224915000992 FeS/SAM binding site; other site 224915000993 histidyl-tRNA synthetase; Region: hisS; TIGR00442 224915000994 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 224915000995 dimer interface [polypeptide binding]; other site 224915000996 motif 1; other site 224915000997 active site 224915000998 motif 2; other site 224915000999 motif 3; other site 224915001000 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 224915001001 anticodon binding site; other site 224915001002 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 224915001003 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 224915001004 dimer interface [polypeptide binding]; other site 224915001005 active site 224915001006 glycine-pyridoxal phosphate binding site [chemical binding]; other site 224915001007 folate binding site [chemical binding]; other site 224915001008 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 224915001009 AAA domain; Region: AAA_26; pfam13500 224915001010 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 224915001011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 224915001012 S-adenosylmethionine binding site [chemical binding]; other site 224915001013 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 224915001014 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 224915001015 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 224915001016 catalytic residue [active] 224915001017 biotin synthase; Provisional; Region: PRK15108 224915001018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 224915001019 FeS/SAM binding site; other site 224915001020 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 224915001021 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 224915001022 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 224915001023 inhibitor-cofactor binding pocket; inhibition site 224915001024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 224915001025 catalytic residue [active] 224915001026 6-phosphogluconolactonase; Provisional; Region: PRK11028 224915001027 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 224915001028 DEAD-like helicases superfamily; Region: DEXDc; smart00487 224915001029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 224915001030 ATP binding site [chemical binding]; other site 224915001031 putative Mg++ binding site [ion binding]; other site 224915001032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 224915001033 nucleotide binding region [chemical binding]; other site 224915001034 ATP-binding site [chemical binding]; other site 224915001035 TRCF domain; Region: TRCF; pfam03461 224915001036 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 224915001037 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 224915001038 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 224915001039 flavodoxin FldA; Validated; Region: PRK09267 224915001040 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 224915001041 DNA photolyase; Region: DNA_photolyase; pfam00875 224915001042 Uncharacterized conserved protein [Function unknown]; Region: COG0327 224915001043 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 224915001044 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 224915001045 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 224915001046 TPP-binding site [chemical binding]; other site 224915001047 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 224915001048 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 224915001049 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 224915001050 E3 interaction surface; other site 224915001051 lipoyl attachment site [posttranslational modification]; other site 224915001052 e3 binding domain; Region: E3_binding; pfam02817 224915001053 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 224915001054 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 224915001055 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 224915001056 ligand binding site [chemical binding]; other site 224915001057 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 224915001058 catalytic core [active] 224915001059 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 224915001060 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 224915001061 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 224915001062 active site 224915001063 ADP/pyrophosphate binding site [chemical binding]; other site 224915001064 dimerization interface [polypeptide binding]; other site 224915001065 allosteric effector site; other site 224915001066 fructose-1,6-bisphosphate binding site; other site 224915001067 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 224915001068 triosephosphate isomerase; Provisional; Region: PRK14565 224915001069 substrate binding site [chemical binding]; other site 224915001070 dimer interface [polypeptide binding]; other site 224915001071 catalytic triad [active] 224915001072 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 224915001073 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 224915001074 RNA binding site [nucleotide binding]; other site 224915001075 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 224915001076 RNA binding site [nucleotide binding]; other site 224915001077 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 224915001078 RNA binding site [nucleotide binding]; other site 224915001079 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 224915001080 RNA binding site [nucleotide binding]; other site 224915001081 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 224915001082 RNA binding site [nucleotide binding]; other site 224915001083 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 224915001084 RNA binding site [nucleotide binding]; other site 224915001085 cytidylate kinase; Provisional; Region: cmk; PRK00023 224915001086 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 224915001087 CMP-binding site; other site 224915001088 The sites determining sugar specificity; other site 224915001089 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 224915001090 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 224915001091 hinge; other site 224915001092 active site 224915001093 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 224915001094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 224915001095 catalytic residue [active] 224915001096 seryl-tRNA synthetase; Provisional; Region: PRK05431 224915001097 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 224915001098 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 224915001099 dimer interface [polypeptide binding]; other site 224915001100 active site 224915001101 motif 1; other site 224915001102 motif 2; other site 224915001103 motif 3; other site 224915001104 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 224915001105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 224915001106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 224915001107 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 224915001108 rRNA binding site [nucleotide binding]; other site 224915001109 predicted 30S ribosome binding site; other site 224915001110 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 224915001111 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 224915001112 dimer interface [polypeptide binding]; other site 224915001113 anticodon binding site; other site 224915001114 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 224915001115 homodimer interface [polypeptide binding]; other site 224915001116 motif 1; other site 224915001117 active site 224915001118 motif 2; other site 224915001119 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 224915001120 active site 224915001121 motif 3; other site 224915001122 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 224915001123 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 224915001124 ABC-ATPase subunit interface; other site 224915001125 dimer interface [polypeptide binding]; other site 224915001126 putative PBP binding regions; other site 224915001127 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 224915001128 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 224915001129 putative peptidase; Provisional; Region: PRK11649 224915001130 Peptidase family M23; Region: Peptidase_M23; pfam01551 224915001131 pyruvate kinase; Provisional; Region: PRK05826 224915001132 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 224915001133 domain interfaces; other site 224915001134 active site 224915001135 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 224915001136 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 224915001137 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 224915001138 heat shock protein HtpX; Provisional; Region: PRK05457 224915001139 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 224915001140 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 224915001141 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 224915001142 Transporter associated domain; Region: CorC_HlyC; smart01091 224915001143 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 224915001144 Glycoprotease family; Region: Peptidase_M22; pfam00814 224915001145 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 224915001146 cell division inhibitor MinD; Provisional; Region: PRK10818 224915001147 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 224915001148 Switch I; other site 224915001149 Switch II; other site 224915001150 septum formation inhibitor; Reviewed; Region: minC; PRK03511 224915001151 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 224915001152 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 224915001153 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 224915001154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 224915001155 S-adenosylmethionine binding site [chemical binding]; other site 224915001156 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 224915001157 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 224915001158 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 224915001159 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 224915001160 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 224915001161 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12641 224915001162 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 224915001163 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 224915001164 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 224915001165 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 224915001166 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 224915001167 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 224915001168 Flagellar L-ring protein; Region: FlgH; pfam02107 224915001169 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 224915001170 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 224915001171 Rod binding protein; Region: Rod-binding; cl01626 224915001172 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 224915001173 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 224915001174 homodimer interface [polypeptide binding]; other site 224915001175 oligonucleotide binding site [chemical binding]; other site 224915001176 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 224915001177 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 224915001178 RNA binding surface [nucleotide binding]; other site 224915001179 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 224915001180 active site 224915001181 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 224915001182 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 224915001183 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 224915001184 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 224915001185 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 224915001186 NAD(P) binding site [chemical binding]; other site 224915001187 homotetramer interface [polypeptide binding]; other site 224915001188 homodimer interface [polypeptide binding]; other site 224915001189 active site 224915001190 acyl carrier protein; Provisional; Region: acpP; PRK00982 224915001191 thymidylate kinase; Validated; Region: tmk; PRK00698 224915001192 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 224915001193 TMP-binding site; other site 224915001194 ATP-binding site [chemical binding]; other site 224915001195 DNA polymerase III subunit delta'; Validated; Region: PRK07993 224915001196 DNA polymerase III subunit delta'; Validated; Region: PRK08485 224915001197 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 224915001198 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 224915001199 active site 224915001200 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 224915001201 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 224915001202 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 224915001203 active site turn [active] 224915001204 phosphorylation site [posttranslational modification] 224915001205 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 224915001206 nucleotide binding site/active site [active] 224915001207 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 224915001208 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 224915001209 putative dimer interface [polypeptide binding]; other site 224915001210 putative anticodon binding site; other site 224915001211 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 224915001212 motif 1; other site 224915001213 dimer interface [polypeptide binding]; other site 224915001214 active site 224915001215 motif 2; other site 224915001216 motif 3; other site 224915001217 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 224915001218 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 224915001219 active site residue [active] 224915001220 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 224915001221 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224915001222 active site 224915001223 HIGH motif; other site 224915001224 nucleotide binding site [chemical binding]; other site 224915001225 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 224915001226 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 224915001227 active site 224915001228 KMSKS motif; other site 224915001229 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 224915001230 tRNA binding surface [nucleotide binding]; other site 224915001231 anticodon binding site; other site 224915001232 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 224915001233 multifunctional aminopeptidase A; Provisional; Region: PRK00913 224915001234 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 224915001235 interface (dimer of trimers) [polypeptide binding]; other site 224915001236 Substrate-binding/catalytic site; other site 224915001237 Zn-binding sites [ion binding]; other site 224915001238 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 224915001239 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 224915001240 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 224915001241 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 224915001242 homotrimer interaction site [polypeptide binding]; other site 224915001243 putative active site [active] 224915001244 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 224915001245 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 224915001246 ATP binding site [chemical binding]; other site 224915001247 Mg++ binding site [ion binding]; other site 224915001248 motif III; other site 224915001249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 224915001250 nucleotide binding region [chemical binding]; other site 224915001251 ATP-binding site [chemical binding]; other site 224915001252 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 224915001253 putative RNA binding site [nucleotide binding]; other site 224915001254 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 224915001255 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 224915001256 RNase E interface [polypeptide binding]; other site 224915001257 trimer interface [polypeptide binding]; other site 224915001258 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 224915001259 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 224915001260 RNase E interface [polypeptide binding]; other site 224915001261 trimer interface [polypeptide binding]; other site 224915001262 active site 224915001263 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 224915001264 putative nucleic acid binding region [nucleotide binding]; other site 224915001265 G-X-X-G motif; other site 224915001266 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 224915001267 RNA binding site [nucleotide binding]; other site 224915001268 domain interface; other site 224915001269 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 224915001270 16S/18S rRNA binding site [nucleotide binding]; other site 224915001271 S13e-L30e interaction site [polypeptide binding]; other site 224915001272 25S rRNA binding site [nucleotide binding]; other site 224915001273 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 224915001274 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 224915001275 RNA binding site [nucleotide binding]; other site 224915001276 active site 224915001277 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 224915001278 Ribosome-binding factor A; Region: RBFA; pfam02033 224915001279 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 224915001280 translation initiation factor IF-2; Region: IF-2; TIGR00487 224915001281 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 224915001282 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 224915001283 G1 box; other site 224915001284 putative GEF interaction site [polypeptide binding]; other site 224915001285 GTP/Mg2+ binding site [chemical binding]; other site 224915001286 Switch I region; other site 224915001287 G2 box; other site 224915001288 G3 box; other site 224915001289 Switch II region; other site 224915001290 G4 box; other site 224915001291 G5 box; other site 224915001292 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 224915001293 Translation-initiation factor 2; Region: IF-2; pfam11987 224915001294 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 224915001295 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 224915001296 NusA N-terminal domain; Region: NusA_N; pfam08529 224915001297 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 224915001298 RNA binding site [nucleotide binding]; other site 224915001299 homodimer interface [polypeptide binding]; other site 224915001300 NusA-like KH domain; Region: KH_5; pfam13184 224915001301 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 224915001302 G-X-X-G motif; other site 224915001303 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 224915001304 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 224915001305 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 224915001306 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 224915001307 active site 224915001308 substrate binding site [chemical binding]; other site 224915001309 metal binding site [ion binding]; metal-binding site 224915001310 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 224915001311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224915001312 Walker A motif; other site 224915001313 ATP binding site [chemical binding]; other site 224915001314 Walker B motif; other site 224915001315 arginine finger; other site 224915001316 Peptidase family M41; Region: Peptidase_M41; pfam01434 224915001317 FtsJ-like methyltransferase; Region: FtsJ; cl17430 224915001318 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 224915001319 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 224915001320 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 224915001321 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 224915001322 BolA-like protein; Region: BolA; cl00386 224915001323 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 224915001324 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 224915001325 hinge; other site 224915001326 active site 224915001327 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 224915001328 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 224915001329 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 224915001330 GTP1/OBG; Region: GTP1_OBG; pfam01018 224915001331 Obg GTPase; Region: Obg; cd01898 224915001332 G1 box; other site 224915001333 GTP/Mg2+ binding site [chemical binding]; other site 224915001334 Switch I region; other site 224915001335 G2 box; other site 224915001336 G3 box; other site 224915001337 Switch II region; other site 224915001338 G4 box; other site 224915001339 G5 box; other site 224915001340 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 224915001341 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 224915001342 23S rRNA interface [nucleotide binding]; other site 224915001343 L3 interface [polypeptide binding]; other site 224915001344 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 224915001345 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 224915001346 Prephenate dehydratase; Region: PDT; pfam00800 224915001347 signal recognition particle protein; Provisional; Region: PRK10867 224915001348 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 224915001349 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 224915001350 P loop; other site 224915001351 GTP binding site [chemical binding]; other site 224915001352 Signal peptide binding domain; Region: SRP_SPB; pfam02978 224915001353 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 224915001354 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14590 224915001355 RimM N-terminal domain; Region: RimM; pfam01782 224915001356 PRC-barrel domain; Region: PRC; pfam05239 224915001357 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 224915001358 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 224915001359 protease TldD; Provisional; Region: tldD; PRK10735 224915001360 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 224915001361 Dehydroquinase class II; Region: DHquinase_II; pfam01220 224915001362 active site 224915001363 trimer interface [polypeptide binding]; other site 224915001364 dimer interface [polypeptide binding]; other site 224915001365 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 224915001366 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 224915001367 RNA binding surface [nucleotide binding]; other site 224915001368 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 224915001369 active site 224915001370 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 224915001371 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 224915001372 motif 1; other site 224915001373 active site 224915001374 motif 2; other site 224915001375 motif 3; other site 224915001376 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 224915001377 carbon storage regulator; Provisional; Region: PRK01712 224915001378 glutamate--cysteine ligase; Provisional; Region: PRK02107 224915001379 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 224915001380 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 224915001381 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 224915001382 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 224915001383 tetramer (dimer of dimers) interface [polypeptide binding]; other site 224915001384 active site 224915001385 dimer interface [polypeptide binding]; other site 224915001386 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 224915001387 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224915001388 active site 224915001389 HIGH motif; other site 224915001390 nucleotide binding site [chemical binding]; other site 224915001391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224915001392 active site 224915001393 KMSKS motif; other site 224915001394 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 224915001395 CTP synthetase; Validated; Region: pyrG; PRK05380 224915001396 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 224915001397 Catalytic site [active] 224915001398 active site 224915001399 UTP binding site [chemical binding]; other site 224915001400 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 224915001401 active site 224915001402 putative oxyanion hole; other site 224915001403 catalytic triad [active] 224915001404 enolase; Provisional; Region: eno; PRK00077 224915001405 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 224915001406 dimer interface [polypeptide binding]; other site 224915001407 metal binding site [ion binding]; metal-binding site 224915001408 substrate binding pocket [chemical binding]; other site 224915001409 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 224915001410 MutS domain I; Region: MutS_I; pfam01624 224915001411 MutS domain II; Region: MutS_II; pfam05188 224915001412 MutS domain III; Region: MutS_III; pfam05192 224915001413 MutS domain V; Region: MutS_V; pfam00488 224915001414 Walker A/P-loop; other site 224915001415 ATP binding site [chemical binding]; other site 224915001416 Q-loop/lid; other site 224915001417 ABC transporter signature motif; other site 224915001418 Walker B; other site 224915001419 D-loop; other site 224915001420 H-loop/switch region; other site 224915001421 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 224915001422 catalytic residues [active] 224915001423 hinge region; other site 224915001424 alpha helical domain; other site 224915001425 5'-3' exonuclease; Provisional; Region: PRK14976 224915001426 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 224915001427 active site 224915001428 metal binding site 1 [ion binding]; metal-binding site 224915001429 putative 5' ssDNA interaction site; other site 224915001430 metal binding site 3; metal-binding site 224915001431 metal binding site 2 [ion binding]; metal-binding site 224915001432 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 224915001433 putative DNA binding site [nucleotide binding]; other site 224915001434 putative metal binding site [ion binding]; other site 224915001435 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 224915001436 G1 box; other site 224915001437 GTP/Mg2+ binding site [chemical binding]; other site 224915001438 Switch I region; other site 224915001439 G2 box; other site 224915001440 G3 box; other site 224915001441 Switch II region; other site 224915001442 G4 box; other site 224915001443 G5 box; other site 224915001444 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 224915001445 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 224915001446 G1 box; other site 224915001447 putative GEF interaction site [polypeptide binding]; other site 224915001448 GTP/Mg2+ binding site [chemical binding]; other site 224915001449 Switch I region; other site 224915001450 G2 box; other site 224915001451 G3 box; other site 224915001452 Switch II region; other site 224915001453 G4 box; other site 224915001454 G5 box; other site 224915001455 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 224915001456 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 224915001457 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 224915001458 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 224915001459 catalytic site [active] 224915001460 G-X2-G-X-G-K; other site 224915001461 thymidylate synthase; Reviewed; Region: thyA; PRK01827 224915001462 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 224915001463 dimerization interface [polypeptide binding]; other site 224915001464 active site 224915001465 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 224915001466 diaminopimelate decarboxylase; Provisional; Region: PRK11165 224915001467 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 224915001468 active site 224915001469 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 224915001470 substrate binding site [chemical binding]; other site 224915001471 catalytic residues [active] 224915001472 dimer interface [polypeptide binding]; other site 224915001473 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 224915001474 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 224915001475 dimer interface [polypeptide binding]; other site 224915001476 putative anticodon binding site; other site 224915001477 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 224915001478 motif 1; other site 224915001479 active site 224915001480 motif 2; other site 224915001481 motif 3; other site 224915001482 peptide chain release factor 2; Validated; Region: prfB; PRK00578 224915001483 This domain is found in peptide chain release factors; Region: PCRF; smart00937 224915001484 RF-1 domain; Region: RF-1; pfam00472 224915001485 putative global regulator; Reviewed; Region: PRK09559 224915001486 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 224915001487 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 224915001488 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 224915001489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 224915001490 FeS/SAM binding site; other site 224915001491 TRAM domain; Region: TRAM; pfam01938 224915001492 metal-binding heat shock protein; Provisional; Region: PRK00016 224915001493 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 224915001494 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 224915001495 Transporter associated domain; Region: CorC_HlyC; smart01091 224915001496 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 224915001497 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 224915001498 HIGH motif; other site 224915001499 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 224915001500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224915001501 active site 224915001502 KMSKS motif; other site 224915001503 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 224915001504 tRNA binding surface [nucleotide binding]; other site 224915001505 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 224915001506 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 224915001507 CPxP motif; other site 224915001508 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 224915001509 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 224915001510 putative antibiotic transporter; Provisional; Region: PRK10739 224915001511 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 224915001512 Phosphoglycerate kinase; Region: PGK; pfam00162 224915001513 substrate binding site [chemical binding]; other site 224915001514 hinge regions; other site 224915001515 ADP binding site [chemical binding]; other site 224915001516 catalytic site [active] 224915001517 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 224915001518 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 224915001519 active site 224915001520 intersubunit interface [polypeptide binding]; other site 224915001521 zinc binding site [ion binding]; other site 224915001522 Na+ binding site [ion binding]; other site 224915001523 mechanosensitive channel MscS; Provisional; Region: PRK10334 224915001524 Mechanosensitive ion channel; Region: MS_channel; pfam00924 224915001525 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 224915001526 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 224915001527 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 224915001528 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 224915001529 AAA domain; Region: AAA_30; pfam13604 224915001530 Family description; Region: UvrD_C_2; pfam13538 224915001531 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 224915001532 homopentamer interface [polypeptide binding]; other site 224915001533 active site 224915001534 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 224915001535 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 224915001536 catalytic motif [active] 224915001537 Zn binding site [ion binding]; other site 224915001538 RibD C-terminal domain; Region: RibD_C; cl17279 224915001539 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 224915001540 putative RNA binding site [nucleotide binding]; other site 224915001541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 224915001542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 224915001543 putative substrate translocation pore; other site 224915001544 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 224915001545 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 224915001546 UbiA prenyltransferase family; Region: UbiA; pfam01040 224915001547 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 224915001548 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 224915001549 Subunit I/III interface [polypeptide binding]; other site 224915001550 Subunit III/IV interface [polypeptide binding]; other site 224915001551 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 224915001552 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 224915001553 D-pathway; other site 224915001554 Putative ubiquinol binding site [chemical binding]; other site 224915001555 Low-spin heme (heme b) binding site [chemical binding]; other site 224915001556 Putative water exit pathway; other site 224915001557 Binuclear center (heme o3/CuB) [ion binding]; other site 224915001558 K-pathway; other site 224915001559 Putative proton exit pathway; other site 224915001560 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 224915001561 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 224915001562 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 224915001563 BolA-like protein; Region: BolA; cl00386 224915001564 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 224915001565 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 224915001566 oligomer interface [polypeptide binding]; other site 224915001567 active site residues [active] 224915001568 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 224915001569 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 224915001570 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 224915001571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224915001572 Walker A motif; other site 224915001573 ATP binding site [chemical binding]; other site 224915001574 Walker B motif; other site 224915001575 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 224915001576 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 224915001577 Found in ATP-dependent protease La (LON); Region: LON; smart00464 224915001578 Found in ATP-dependent protease La (LON); Region: LON; smart00464 224915001579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224915001580 Walker A motif; other site 224915001581 ATP binding site [chemical binding]; other site 224915001582 Walker B motif; other site 224915001583 arginine finger; other site 224915001584 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 224915001585 periplasmic folding chaperone; Provisional; Region: PRK10788 224915001586 periplasmic folding chaperone; Provisional; Region: PRK10788 224915001587 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 224915001588 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 224915001589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 224915001590 Walker A/P-loop; other site 224915001591 ATP binding site [chemical binding]; other site 224915001592 Q-loop/lid; other site 224915001593 ABC transporter signature motif; other site 224915001594 Walker B; other site 224915001595 D-loop; other site 224915001596 H-loop/switch region; other site 224915001597 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 224915001598 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 224915001599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 224915001600 Walker A/P-loop; other site 224915001601 ATP binding site [chemical binding]; other site 224915001602 Q-loop/lid; other site 224915001603 ABC transporter signature motif; other site 224915001604 Walker B; other site 224915001605 D-loop; other site 224915001606 H-loop/switch region; other site 224915001607 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 224915001608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224915001609 Walker A motif; other site 224915001610 ATP binding site [chemical binding]; other site 224915001611 Walker B motif; other site 224915001612 DNA polymerase III subunit delta'; Validated; Region: PRK08485 224915001613 arginine finger; other site 224915001614 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 224915001615 hypothetical protein; Validated; Region: PRK00153 224915001616 heat shock protein 90; Provisional; Region: PRK05218 224915001617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 224915001618 ATP binding site [chemical binding]; other site 224915001619 Mg2+ binding site [ion binding]; other site 224915001620 G-X-G motif; other site 224915001621 adenylate kinase; Reviewed; Region: adk; PRK00279 224915001622 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 224915001623 AMP-binding site [chemical binding]; other site 224915001624 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 224915001625 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 224915001626 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 224915001627 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 224915001628 homodimer interface [polypeptide binding]; other site 224915001629 NADP binding site [chemical binding]; other site 224915001630 substrate binding site [chemical binding]; other site 224915001631 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 224915001632 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 224915001633 active site 224915001634 HIGH motif; other site 224915001635 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 224915001636 active site 224915001637 KMSKS motif; other site 224915001638 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 224915001639 tRNA binding surface [nucleotide binding]; other site 224915001640 anticodon binding site; other site 224915001641 hypothetical protein; Provisional; Region: PRK04998 224915001642 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 224915001643 DNA-binding site [nucleotide binding]; DNA binding site 224915001644 RNA-binding motif; other site 224915001645 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 224915001646 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 224915001647 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 224915001648 shikimate binding site; other site 224915001649 NAD(P) binding site [chemical binding]; other site 224915001650 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 224915001651 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 224915001652 active site 224915001653 catalytic residues [active] 224915001654 metal binding site [ion binding]; metal-binding site 224915001655 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 224915001656 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 224915001657 putative active site [active] 224915001658 substrate binding site [chemical binding]; other site 224915001659 putative cosubstrate binding site; other site 224915001660 catalytic site [active] 224915001661 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 224915001662 substrate binding site [chemical binding]; other site 224915001663 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 224915001664 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 224915001665 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 224915001666 alphaNTD homodimer interface [polypeptide binding]; other site 224915001667 alphaNTD - beta interaction site [polypeptide binding]; other site 224915001668 alphaNTD - beta' interaction site [polypeptide binding]; other site 224915001669 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 224915001670 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 224915001671 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 224915001672 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 224915001673 RNA binding surface [nucleotide binding]; other site 224915001674 30S ribosomal protein S11; Validated; Region: PRK05309 224915001675 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 224915001676 30S ribosomal protein S13; Region: bact_S13; TIGR03631 224915001677 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 224915001678 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 224915001679 SecY translocase; Region: SecY; pfam00344 224915001680 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 224915001681 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 224915001682 23S rRNA binding site [nucleotide binding]; other site 224915001683 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 224915001684 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 224915001685 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 224915001686 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 224915001687 5S rRNA interface [nucleotide binding]; other site 224915001688 23S rRNA interface [nucleotide binding]; other site 224915001689 L5 interface [polypeptide binding]; other site 224915001690 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 224915001691 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 224915001692 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 224915001693 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 224915001694 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 224915001695 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 224915001696 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 224915001697 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 224915001698 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 224915001699 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 224915001700 RNA binding site [nucleotide binding]; other site 224915001701 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 224915001702 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 224915001703 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 224915001704 putative translocon interaction site; other site 224915001705 signal recognition particle (SRP54) interaction site; other site 224915001706 L23 interface [polypeptide binding]; other site 224915001707 trigger factor interaction site; other site 224915001708 23S rRNA interface [nucleotide binding]; other site 224915001709 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 224915001710 23S rRNA interface [nucleotide binding]; other site 224915001711 5S rRNA interface [nucleotide binding]; other site 224915001712 putative antibiotic binding site [chemical binding]; other site 224915001713 L25 interface [polypeptide binding]; other site 224915001714 L27 interface [polypeptide binding]; other site 224915001715 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 224915001716 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 224915001717 G-X-X-G motif; other site 224915001718 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 224915001719 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 224915001720 protein-rRNA interface [nucleotide binding]; other site 224915001721 putative translocon binding site; other site 224915001722 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 224915001723 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 224915001724 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 224915001725 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 224915001726 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 224915001727 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 224915001728 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 224915001729 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 224915001730 elongation factor Tu; Reviewed; Region: PRK00049 224915001731 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 224915001732 G1 box; other site 224915001733 GEF interaction site [polypeptide binding]; other site 224915001734 GTP/Mg2+ binding site [chemical binding]; other site 224915001735 Switch I region; other site 224915001736 G2 box; other site 224915001737 G3 box; other site 224915001738 Switch II region; other site 224915001739 G4 box; other site 224915001740 G5 box; other site 224915001741 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 224915001742 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 224915001743 Antibiotic Binding Site [chemical binding]; other site 224915001744 elongation factor G; Reviewed; Region: PRK00007 224915001745 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 224915001746 G1 box; other site 224915001747 putative GEF interaction site [polypeptide binding]; other site 224915001748 GTP/Mg2+ binding site [chemical binding]; other site 224915001749 Switch I region; other site 224915001750 G2 box; other site 224915001751 G3 box; other site 224915001752 Switch II region; other site 224915001753 G4 box; other site 224915001754 G5 box; other site 224915001755 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 224915001756 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 224915001757 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 224915001758 30S ribosomal protein S7; Validated; Region: PRK05302 224915001759 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 224915001760 S17 interaction site [polypeptide binding]; other site 224915001761 S8 interaction site; other site 224915001762 16S rRNA interaction site [nucleotide binding]; other site 224915001763 streptomycin interaction site [chemical binding]; other site 224915001764 23S rRNA interaction site [nucleotide binding]; other site 224915001765 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 224915001766 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 224915001767 sulfur relay protein TusC; Validated; Region: PRK00211 224915001768 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 224915001769 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 224915001770 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 224915001771 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 224915001772 putative transporter; Provisional; Region: PRK03699 224915001773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 224915001774 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 224915001775 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 224915001776 active site 224915001777 HIGH motif; other site 224915001778 dimer interface [polypeptide binding]; other site 224915001779 KMSKS motif; other site 224915001780 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 224915001781 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 224915001782 substrate binding site [chemical binding]; other site 224915001783 hexamer interface [polypeptide binding]; other site 224915001784 metal binding site [ion binding]; metal-binding site 224915001785 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 224915001786 active site 224915001787 dimer interface [polypeptide binding]; other site 224915001788 metal binding site [ion binding]; metal-binding site 224915001789 shikimate kinase; Reviewed; Region: aroK; PRK00131 224915001790 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 224915001791 ADP binding site [chemical binding]; other site 224915001792 magnesium binding site [ion binding]; other site 224915001793 putative shikimate binding site; other site 224915001794 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 224915001795 phosphopentomutase; Provisional; Region: PRK05362 224915001796 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 224915001797 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 224915001798 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 224915001799 G1 box; other site 224915001800 putative GEF interaction site [polypeptide binding]; other site 224915001801 GTP/Mg2+ binding site [chemical binding]; other site 224915001802 Switch I region; other site 224915001803 G2 box; other site 224915001804 G3 box; other site 224915001805 Switch II region; other site 224915001806 G4 box; other site 224915001807 G5 box; other site 224915001808 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 224915001809 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 224915001810 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 224915001811 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 224915001812 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 224915001813 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 224915001814 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 224915001815 dimer interface [polypeptide binding]; other site 224915001816 ssDNA binding site [nucleotide binding]; other site 224915001817 tetramer (dimer of dimers) interface [polypeptide binding]; other site 224915001818 replicative DNA helicase; Provisional; Region: PRK08006 224915001819 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 224915001820 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 224915001821 Walker A motif; other site 224915001822 ATP binding site [chemical binding]; other site 224915001823 Walker B motif; other site 224915001824 DNA binding loops [nucleotide binding] 224915001825 glutathione synthetase; Provisional; Region: PRK05246 224915001826 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 224915001827 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 224915001828 hypothetical protein; Validated; Region: PRK00228 224915001829 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 224915001830 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 224915001831 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 224915001832 active site 224915001833 catalytic residues [active] 224915001834 metal binding site [ion binding]; metal-binding site 224915001835 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 224915001836 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 224915001837 substrate binding site [chemical binding]; other site 224915001838 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 224915001839 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 224915001840 substrate binding site [chemical binding]; other site 224915001841 ligand binding site [chemical binding]; other site 224915001842 tartrate dehydrogenase; Region: TTC; TIGR02089 224915001843 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 224915001844 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 224915001845 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 224915001846 catalytic residue [active] 224915001847 HemN family oxidoreductase; Provisional; Region: PRK05660 224915001848 HemN C-terminal domain; Region: HemN_C; pfam06969 224915001849 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 224915001850 adenine DNA glycosylase; Provisional; Region: PRK10880 224915001851 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 224915001852 minor groove reading motif; other site 224915001853 helix-hairpin-helix signature motif; other site 224915001854 substrate binding pocket [chemical binding]; other site 224915001855 active site 224915001856 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 224915001857 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 224915001858 DNA binding and oxoG recognition site [nucleotide binding] 224915001859 Bacterial Fe(2+) trafficking; Region: Iron_traffic; pfam04362 224915001860 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 224915001861 exonuclease I; Provisional; Region: sbcB; PRK11779 224915001862 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 224915001863 active site 224915001864 catalytic site [active] 224915001865 substrate binding site [chemical binding]; other site 224915001866 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 224915001867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 224915001868 active site 224915001869 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 224915001870 trimer interface [polypeptide binding]; other site 224915001871 active site 224915001872 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 224915001873 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 224915001874 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 224915001875 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 224915001876 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 224915001877 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 224915001878 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 224915001879 GDP-binding site [chemical binding]; other site 224915001880 ACT binding site; other site 224915001881 IMP binding site; other site 224915001882 HflC protein; Region: hflC; TIGR01932 224915001883 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 224915001884 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 224915001885 HflK protein; Region: hflK; TIGR01933 224915001886 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 224915001887 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 224915001888 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 224915001889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 224915001890 ATP binding site [chemical binding]; other site 224915001891 Mg2+ binding site [ion binding]; other site 224915001892 G-X-G motif; other site 224915001893 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 224915001894 ATP binding site [chemical binding]; other site 224915001895 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 224915001896 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 224915001897 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 224915001898 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 224915001899 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 224915001900 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 224915001901 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 224915001902 active site 224915001903 P-loop; other site 224915001904 phosphorylation site [posttranslational modification] 224915001905 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 224915001906 active site 224915001907 phosphorylation site [posttranslational modification] 224915001908 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 224915001909 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 224915001910 active site 224915001911 dimer interface [polypeptide binding]; other site 224915001912 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 224915001913 dimer interface [polypeptide binding]; other site 224915001914 active site 224915001915 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 224915001916 catalytic site [active] 224915001917 putative active site [active] 224915001918 putative substrate binding site [chemical binding]; other site 224915001919 dimer interface [polypeptide binding]; other site 224915001920 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 224915001921 active site 224915001922 metal binding site [ion binding]; metal-binding site 224915001923 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 224915001924 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 224915001925 active site 224915001926 HslU subunit interaction site [polypeptide binding]; other site 224915001927 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 224915001928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224915001929 Walker A motif; other site 224915001930 ATP binding site [chemical binding]; other site 224915001931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 224915001932 Walker B motif; other site 224915001933 arginine finger; other site 224915001934 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 224915001935 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 224915001936 Glutamine amidotransferase class-I; Region: GATase; pfam00117 224915001937 glutamine binding [chemical binding]; other site 224915001938 catalytic triad [active] 224915001939 anthranilate synthase component I; Provisional; Region: PRK13564 224915001940 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 224915001941 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 224915001942 ferredoxin-NADP reductase; Provisional; Region: PRK10926 224915001943 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 224915001944 FAD binding pocket [chemical binding]; other site 224915001945 FAD binding motif [chemical binding]; other site 224915001946 phosphate binding motif [ion binding]; other site 224915001947 beta-alpha-beta structure motif; other site 224915001948 NAD binding pocket [chemical binding]; other site 224915001949 poxB regulator PoxA; Provisional; Region: PRK09350 224915001950 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 224915001951 motif 1; other site 224915001952 dimer interface [polypeptide binding]; other site 224915001953 active site 224915001954 motif 2; other site 224915001955 motif 3; other site 224915001956 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 224915001957 Ligand Binding Site [chemical binding]; other site 224915001958 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 224915001959 Phosphate transporter family; Region: PHO4; pfam01384 224915001960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 224915001961 putative substrate translocation pore; other site 224915001962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 224915001963 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 224915001964 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 224915001965 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 224915001966 iron donor protein CyaY; Region: FeS_CyaY; TIGR03421 224915001967 putative iron binding site [ion binding]; other site 224915001968 transcription termination factor Rho; Provisional; Region: rho; PRK09376 224915001969 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 224915001970 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 224915001971 RNA binding site [nucleotide binding]; other site 224915001972 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 224915001973 multimer interface [polypeptide binding]; other site 224915001974 Walker A motif; other site 224915001975 ATP binding site [chemical binding]; other site 224915001976 Walker B motif; other site 224915001977 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 224915001978 catalytic residues [active] 224915001979 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 224915001980 Part of AAA domain; Region: AAA_19; pfam13245 224915001981 Family description; Region: UvrD_C_2; pfam13538 224915001982 ketol-acid reductoisomerase; Validated; Region: PRK05225 224915001983 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 224915001984 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 224915001985 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 224915001986 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 224915001987 cysteine desulfurase; Provisional; Region: PRK14012 224915001988 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 224915001989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 224915001990 catalytic residue [active] 224915001991 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 224915001992 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 224915001993 trimerization site [polypeptide binding]; other site 224915001994 active site 224915001995 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 224915001996 HSP70 interaction site [polypeptide binding]; other site 224915001997 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 224915001998 nucleotide binding site [chemical binding]; other site 224915001999 putative NEF/HSP70 interaction site [polypeptide binding]; other site 224915002000 SBD interface [polypeptide binding]; other site 224915002001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 224915002002 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 224915002003 catalytic loop [active] 224915002004 iron binding site [ion binding]; other site 224915002005 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 224915002006 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 224915002007 G1 box; other site 224915002008 GTP/Mg2+ binding site [chemical binding]; other site 224915002009 Switch I region; other site 224915002010 G2 box; other site 224915002011 Switch II region; other site 224915002012 G3 box; other site 224915002013 G4 box; other site 224915002014 G5 box; other site 224915002015 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 224915002016 G1 box; other site 224915002017 GTP/Mg2+ binding site [chemical binding]; other site 224915002018 Switch I region; other site 224915002019 G2 box; other site 224915002020 G3 box; other site 224915002021 Switch II region; other site 224915002022 G4 box; other site 224915002023 G5 box; other site 224915002024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 224915002025 hypothetical protein; Provisional; Region: PRK05208 224915002026 IncFII RepA protein family; Region: IncFII_repA; cl11495 224915002027 IncFII RepA protein family; Region: IncFII_repA; pfam02387