-- dump date   	20140619_011847
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
224915000001	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
224915000002	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
224915000003	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
224915000004	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
224915000005	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
224915000006	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
224915000007	ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260
224915000008	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
224915000009	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
224915000010	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
224915000011	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
224915000012	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
224915000013	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
224915000014	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
224915000015	beta subunit interaction interface [polypeptide binding]; other site
224915000016	Walker A motif; other site
224915000017	ATP binding site [chemical binding]; other site
224915000018	Walker B motif; other site
224915000019	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
224915000020	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
224915000021	core domain interface [polypeptide binding]; other site
224915000022	delta subunit interface [polypeptide binding]; other site
224915000023	epsilon subunit interface [polypeptide binding]; other site
224915000024	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
224915000025	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
224915000026	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
224915000027	alpha subunit interaction interface [polypeptide binding]; other site
224915000028	Walker A motif; other site
224915000029	ATP binding site [chemical binding]; other site
224915000030	Walker B motif; other site
224915000031	inhibitor binding site; inhibition site
224915000032	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
224915000033	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
224915000034	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
224915000035	gamma subunit interface [polypeptide binding]; other site
224915000036	epsilon subunit interface [polypeptide binding]; other site
224915000037	LBP interface [polypeptide binding]; other site
224915000038	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
224915000039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224915000040	Mg2+ binding site [ion binding]; other site
224915000041	G-X-G motif; other site
224915000042	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
224915000043	anchoring element; other site
224915000044	dimer interface [polypeptide binding]; other site
224915000045	ATP binding site [chemical binding]; other site
224915000046	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
224915000047	active site
224915000048	putative metal-binding site [ion binding]; other site
224915000049	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
224915000050	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
224915000051	DNA polymerase III subunit beta; Validated; Region: PRK05643
224915000052	putative DNA binding surface [nucleotide binding]; other site
224915000053	dimer interface [polypeptide binding]; other site
224915000054	beta-clamp/clamp loader binding surface; other site
224915000055	beta-clamp/translesion DNA polymerase binding surface; other site
224915000056	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
224915000057	DnaA N-terminal domain; Region: DnaA_N; pfam11638
224915000058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224915000059	Walker A motif; other site
224915000060	ATP binding site [chemical binding]; other site
224915000061	Walker B motif; other site
224915000062	arginine finger; other site
224915000063	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
224915000064	DnaA box-binding interface [nucleotide binding]; other site
224915000065	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
224915000066	Ribonuclease P; Region: Ribonuclease_P; cl00457
224915000067	Haemolytic domain; Region: Haemolytic; pfam01809
224915000068	membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593
224915000069	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
224915000070	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
224915000071	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
224915000072	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
224915000073	trmE is a tRNA modification GTPase; Region: trmE; cd04164
224915000074	G1 box; other site
224915000075	GTP/Mg2+ binding site [chemical binding]; other site
224915000076	Switch I region; other site
224915000077	G2 box; other site
224915000078	Switch II region; other site
224915000079	G3 box; other site
224915000080	G4 box; other site
224915000081	G5 box; other site
224915000082	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
224915000083	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
224915000084	putative DNA-binding cleft [nucleotide binding]; other site
224915000085	putative DNA clevage site; other site
224915000086	molecular lever; other site
224915000087	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
224915000088	oligomerisation interface [polypeptide binding]; other site
224915000089	mobile loop; other site
224915000090	roof hairpin; other site
224915000091	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
224915000092	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
224915000093	ring oligomerisation interface [polypeptide binding]; other site
224915000094	ATP/Mg binding site [chemical binding]; other site
224915000095	stacking interactions; other site
224915000096	hinge regions; other site
224915000097	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
224915000098	Radical SAM superfamily; Region: Radical_SAM; pfam04055
224915000099	translation elongation factor P; Region: efp; TIGR00038
224915000100	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
224915000101	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
224915000102	RNA binding site [nucleotide binding]; other site
224915000103	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
224915000104	RNA binding site [nucleotide binding]; other site
224915000105	DNA replication protein DnaC; Validated; Region: PRK07952
224915000106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224915000107	Walker A motif; other site
224915000108	ATP binding site [chemical binding]; other site
224915000109	Walker B motif; other site
224915000110	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
224915000111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224915000112	S-adenosylmethionine binding site [chemical binding]; other site
224915000113	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
224915000114	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
224915000115	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
224915000116	P loop; other site
224915000117	GTP binding site [chemical binding]; other site
224915000118	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
224915000119	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224915000120	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224915000121	DNA binding residues [nucleotide binding]
224915000122	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
224915000123	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
224915000124	glutaminase active site [active]
224915000125	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
224915000126	dimer interface [polypeptide binding]; other site
224915000127	active site
224915000128	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
224915000129	dimer interface [polypeptide binding]; other site
224915000130	active site
224915000131	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
224915000132	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
224915000133	Substrate binding site; other site
224915000134	Mg++ binding site; other site
224915000135	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
224915000136	active site
224915000137	substrate binding site [chemical binding]; other site
224915000138	CoA binding site [chemical binding]; other site
224915000139	putative hydrolase; Provisional; Region: PRK10976
224915000140	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224915000141	active site
224915000142	motif I; other site
224915000143	motif II; other site
224915000144	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
224915000145	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
224915000146	THF binding site; other site
224915000147	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
224915000148	substrate binding site [chemical binding]; other site
224915000149	THF binding site; other site
224915000150	zinc-binding site [ion binding]; other site
224915000151	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
224915000152	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
224915000153	purine monophosphate binding site [chemical binding]; other site
224915000154	dimer interface [polypeptide binding]; other site
224915000155	putative catalytic residues [active]
224915000156	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
224915000157	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
224915000158	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
224915000159	IHF dimer interface [polypeptide binding]; other site
224915000160	IHF - DNA interface [nucleotide binding]; other site
224915000161	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
224915000162	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
224915000163	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
224915000164	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
224915000165	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
224915000166	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
224915000167	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
224915000168	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
224915000169	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
224915000170	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
224915000171	DNA binding site [nucleotide binding]
224915000172	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
224915000173	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
224915000174	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
224915000175	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
224915000176	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
224915000177	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
224915000178	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
224915000179	RPB3 interaction site [polypeptide binding]; other site
224915000180	RPB1 interaction site [polypeptide binding]; other site
224915000181	RPB11 interaction site [polypeptide binding]; other site
224915000182	RPB10 interaction site [polypeptide binding]; other site
224915000183	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
224915000184	core dimer interface [polypeptide binding]; other site
224915000185	peripheral dimer interface [polypeptide binding]; other site
224915000186	L10 interface [polypeptide binding]; other site
224915000187	L11 interface [polypeptide binding]; other site
224915000188	putative EF-Tu interaction site [polypeptide binding]; other site
224915000189	putative EF-G interaction site [polypeptide binding]; other site
224915000190	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
224915000191	23S rRNA interface [nucleotide binding]; other site
224915000192	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
224915000193	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
224915000194	mRNA/rRNA interface [nucleotide binding]; other site
224915000195	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
224915000196	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
224915000197	23S rRNA interface [nucleotide binding]; other site
224915000198	L7/L12 interface [polypeptide binding]; other site
224915000199	putative thiostrepton binding site; other site
224915000200	L25 interface [polypeptide binding]; other site
224915000201	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
224915000202	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
224915000203	putative homodimer interface [polypeptide binding]; other site
224915000204	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
224915000205	heterodimer interface [polypeptide binding]; other site
224915000206	homodimer interface [polypeptide binding]; other site
224915000207	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
224915000208	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
224915000209	FAD binding domain; Region: FAD_binding_4; pfam01565
224915000210	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
224915000211	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
224915000212	FAD binding site [chemical binding]; other site
224915000213	argininosuccinate synthase; Provisional; Region: PRK13820
224915000214	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
224915000215	ANP binding site [chemical binding]; other site
224915000216	Substrate Binding Site II [chemical binding]; other site
224915000217	Substrate Binding Site I [chemical binding]; other site
224915000218	argininosuccinate lyase; Provisional; Region: PRK04833
224915000219	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
224915000220	active sites [active]
224915000221	tetramer interface [polypeptide binding]; other site
224915000222	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
224915000223	active site residue [active]
224915000224	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
224915000225	serine O-acetyltransferase; Region: cysE; TIGR01172
224915000226	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
224915000227	trimer interface [polypeptide binding]; other site
224915000228	active site
224915000229	substrate binding site [chemical binding]; other site
224915000230	CoA binding site [chemical binding]; other site
224915000231	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
224915000232	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
224915000233	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
224915000234	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
224915000235	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224915000236	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224915000237	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224915000238	DNA binding residues [nucleotide binding]
224915000239	DNA primase; Validated; Region: dnaG; PRK05667
224915000240	CHC2 zinc finger; Region: zf-CHC2; pfam01807
224915000241	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
224915000242	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
224915000243	active site
224915000244	metal binding site [ion binding]; metal-binding site
224915000245	interdomain interaction site; other site
224915000246	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
224915000247	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
224915000248	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
224915000249	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
224915000250	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
224915000251	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
224915000252	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
224915000253	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13298
224915000254	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
224915000255	active site
224915000256	NTP binding site [chemical binding]; other site
224915000257	metal binding triad [ion binding]; metal-binding site
224915000258	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
224915000259	Bacitracin resistance protein BacA; Region: BacA; pfam02673
224915000260	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
224915000261	HPr interaction site; other site
224915000262	glycerol kinase (GK) interaction site [polypeptide binding]; other site
224915000263	active site
224915000264	phosphorylation site [posttranslational modification]
224915000265	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
224915000266	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
224915000267	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
224915000268	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
224915000269	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
224915000270	dimerization domain swap beta strand [polypeptide binding]; other site
224915000271	regulatory protein interface [polypeptide binding]; other site
224915000272	active site
224915000273	regulatory phosphorylation site [posttranslational modification]; other site
224915000274	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
224915000275	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
224915000276	nucleotide binding pocket [chemical binding]; other site
224915000277	K-X-D-G motif; other site
224915000278	catalytic site [active]
224915000279	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
224915000280	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
224915000281	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
224915000282	HIGH motif; other site
224915000283	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
224915000284	active site
224915000285	KMSKS motif; other site
224915000286	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
224915000287	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
224915000288	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
224915000289	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
224915000290	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
224915000291	FliG C-terminal domain; Region: FliG_C; pfam01706
224915000292	Flagellar assembly protein FliH; Region: FliH; pfam02108
224915000293	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
224915000294	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
224915000295	Walker A motif; other site
224915000296	ATP binding site [chemical binding]; other site
224915000297	Walker B motif; other site
224915000298	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
224915000299	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
224915000300	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
224915000301	flagellar motor switch protein FliN; Region: fliN; TIGR02480
224915000302	putative bifunctional flagellar biosynthesis protein FliO/FliP; Provisional; Region: PRK12430
224915000303	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
224915000304	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
224915000305	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
224915000306	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
224915000307	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
224915000308	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
224915000309	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
224915000310	dimer interface [polypeptide binding]; other site
224915000311	substrate binding site [chemical binding]; other site
224915000312	metal binding sites [ion binding]; metal-binding site
224915000313	peptidase PmbA; Provisional; Region: PRK11040
224915000314	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
224915000315	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
224915000316	putative SAM binding site [chemical binding]; other site
224915000317	putative homodimer interface [polypeptide binding]; other site
224915000318	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
224915000319	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
224915000320	dimer interface [polypeptide binding]; other site
224915000321	active site
224915000322	transaldolase-like protein; Provisional; Region: PTZ00411
224915000323	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
224915000324	active site
224915000325	dimer interface [polypeptide binding]; other site
224915000326	catalytic residue [active]
224915000327	transketolase; Reviewed; Region: PRK12753
224915000328	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
224915000329	TPP-binding site [chemical binding]; other site
224915000330	dimer interface [polypeptide binding]; other site
224915000331	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
224915000332	PYR/PP interface [polypeptide binding]; other site
224915000333	dimer interface [polypeptide binding]; other site
224915000334	TPP binding site [chemical binding]; other site
224915000335	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224915000336	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
224915000337	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
224915000338	metal binding site [ion binding]; metal-binding site
224915000339	dimer interface [polypeptide binding]; other site
224915000340	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
224915000341	dihydrodipicolinate synthase; Region: dapA; TIGR00674
224915000342	dimer interface [polypeptide binding]; other site
224915000343	active site
224915000344	catalytic residue [active]
224915000345	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
224915000346	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
224915000347	Tetramer interface [polypeptide binding]; other site
224915000348	active site
224915000349	FMN-binding site [chemical binding]; other site
224915000350	hypothetical protein; Provisional; Region: PRK04946
224915000351	Smr domain; Region: Smr; pfam01713
224915000352	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
224915000353	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
224915000354	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
224915000355	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
224915000356	histidinol dehydrogenase; Region: hisD; TIGR00069
224915000357	NAD binding site [chemical binding]; other site
224915000358	dimerization interface [polypeptide binding]; other site
224915000359	product binding site; other site
224915000360	substrate binding site [chemical binding]; other site
224915000361	zinc binding site [ion binding]; other site
224915000362	catalytic residues [active]
224915000363	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
224915000364	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224915000365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224915000366	homodimer interface [polypeptide binding]; other site
224915000367	catalytic residue [active]
224915000368	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
224915000369	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224915000370	active site
224915000371	motif I; other site
224915000372	motif II; other site
224915000373	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
224915000374	putative active site pocket [active]
224915000375	4-fold oligomerization interface [polypeptide binding]; other site
224915000376	metal binding residues [ion binding]; metal-binding site
224915000377	3-fold/trimer interface [polypeptide binding]; other site
224915000378	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
224915000379	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
224915000380	putative active site [active]
224915000381	oxyanion strand; other site
224915000382	catalytic triad [active]
224915000383	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
224915000384	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
224915000385	catalytic residues [active]
224915000386	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
224915000387	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
224915000388	substrate binding site [chemical binding]; other site
224915000389	glutamase interaction surface [polypeptide binding]; other site
224915000390	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
224915000391	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
224915000392	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
224915000393	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
224915000394	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
224915000395	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
224915000396	trimer interface [polypeptide binding]; other site
224915000397	active site
224915000398	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
224915000399	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224915000400	active site
224915000401	nucleotide binding site [chemical binding]; other site
224915000402	HIGH motif; other site
224915000403	KMSKS motif; other site
224915000404	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
224915000405	tRNA binding surface [nucleotide binding]; other site
224915000406	anticodon binding site; other site
224915000407	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
224915000408	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
224915000409	Ligand Binding Site [chemical binding]; other site
224915000410	TilS substrate binding domain; Region: TilS; pfam09179
224915000411	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
224915000412	multidrug efflux protein; Reviewed; Region: PRK01766
224915000413	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
224915000414	cation binding site [ion binding]; other site
224915000415	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
224915000416	Lumazine binding domain; Region: Lum_binding; pfam00677
224915000417	Lumazine binding domain; Region: Lum_binding; pfam00677
224915000418	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
224915000419	ferredoxin; Provisional; Region: PRK08764
224915000420	Putative Fe-S cluster; Region: FeS; cl17515
224915000421	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
224915000422	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
224915000423	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
224915000424	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
224915000425	FMN-binding domain; Region: FMN_bind; cl01081
224915000426	electron transport complex RsxE subunit; Provisional; Region: PRK12405
224915000427	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
224915000428	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224915000429	minor groove reading motif; other site
224915000430	helix-hairpin-helix signature motif; other site
224915000431	substrate binding pocket [chemical binding]; other site
224915000432	active site
224915000433	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
224915000434	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
224915000435	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
224915000436	active site
224915000437	HIGH motif; other site
224915000438	dimer interface [polypeptide binding]; other site
224915000439	KMSKS motif; other site
224915000440	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
224915000441	putative inner membrane protein; Provisional; Region: PRK10983
224915000442	Domain of unknown function DUF20; Region: UPF0118; pfam01594
224915000443	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
224915000444	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
224915000445	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
224915000446	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
224915000447	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
224915000448	active site
224915000449	dimer interface [polypeptide binding]; other site
224915000450	motif 1; other site
224915000451	motif 2; other site
224915000452	motif 3; other site
224915000453	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
224915000454	anticodon binding site; other site
224915000455	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
224915000456	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
224915000457	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
224915000458	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
224915000459	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
224915000460	23S rRNA binding site [nucleotide binding]; other site
224915000461	L21 binding site [polypeptide binding]; other site
224915000462	L13 binding site [polypeptide binding]; other site
224915000463	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
224915000464	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
224915000465	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
224915000466	dimer interface [polypeptide binding]; other site
224915000467	motif 1; other site
224915000468	active site
224915000469	motif 2; other site
224915000470	motif 3; other site
224915000471	phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472
224915000472	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
224915000473	putative tRNA-binding site [nucleotide binding]; other site
224915000474	B3/4 domain; Region: B3_4; pfam03483
224915000475	tRNA synthetase B5 domain; Region: B5; smart00874
224915000476	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
224915000477	dimer interface [polypeptide binding]; other site
224915000478	motif 1; other site
224915000479	motif 3; other site
224915000480	motif 2; other site
224915000481	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
224915000482	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
224915000483	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
224915000484	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
224915000485	dimer interface [polypeptide binding]; other site
224915000486	motif 1; other site
224915000487	active site
224915000488	motif 2; other site
224915000489	motif 3; other site
224915000490	endonuclease IV; Provisional; Region: PRK01060
224915000491	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
224915000492	AP (apurinic/apyrimidinic) site pocket; other site
224915000493	DNA interaction; other site
224915000494	Metal-binding active site; metal-binding site
224915000495	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
224915000496	5S rRNA interface [nucleotide binding]; other site
224915000497	CTC domain interface [polypeptide binding]; other site
224915000498	L16 interface [polypeptide binding]; other site
224915000499	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
224915000500	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
224915000501	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
224915000502	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
224915000503	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
224915000504	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
224915000505	active site
224915000506	metal binding site [ion binding]; metal-binding site
224915000507	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
224915000508	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
224915000509	folate binding site [chemical binding]; other site
224915000510	NADP+ binding site [chemical binding]; other site
224915000511	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
224915000512	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224915000513	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
224915000514	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
224915000515	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224915000516	ATP-grasp domain; Region: ATP-grasp_4; cl17255
224915000517	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
224915000518	IMP binding site; other site
224915000519	dimer interface [polypeptide binding]; other site
224915000520	interdomain contacts; other site
224915000521	partial ornithine binding site; other site
224915000522	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
224915000523	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
224915000524	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
224915000525	catalytic site [active]
224915000526	subunit interface [polypeptide binding]; other site
224915000527	dihydrodipicolinate reductase; Provisional; Region: PRK00048
224915000528	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
224915000529	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
224915000530	LytB protein; Region: LYTB; cl00507
224915000531	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
224915000532	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
224915000533	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224915000534	active site
224915000535	HIGH motif; other site
224915000536	nucleotide binding site [chemical binding]; other site
224915000537	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
224915000538	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
224915000539	active site
224915000540	KMSKS motif; other site
224915000541	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
224915000542	tRNA binding surface [nucleotide binding]; other site
224915000543	anticodon binding site; other site
224915000544	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
224915000545	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
224915000546	chaperone protein DnaJ; Provisional; Region: PRK10767
224915000547	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224915000548	HSP70 interaction site [polypeptide binding]; other site
224915000549	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
224915000550	substrate binding site [polypeptide binding]; other site
224915000551	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
224915000552	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
224915000553	dimer interface [polypeptide binding]; other site
224915000554	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
224915000555	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
224915000556	nucleotide binding site [chemical binding]; other site
224915000557	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
224915000558	NADH dehydrogenase subunit B; Validated; Region: PRK06411
224915000559	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
224915000560	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
224915000561	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
224915000562	NADH dehydrogenase subunit E; Validated; Region: PRK07539
224915000563	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
224915000564	putative dimer interface [polypeptide binding]; other site
224915000565	[2Fe-2S] cluster binding site [ion binding]; other site
224915000566	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
224915000567	SLBB domain; Region: SLBB; pfam10531
224915000568	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
224915000569	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224915000570	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
224915000571	catalytic loop [active]
224915000572	iron binding site [ion binding]; other site
224915000573	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
224915000574	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
224915000575	[4Fe-4S] binding site [ion binding]; other site
224915000576	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
224915000577	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
224915000578	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
224915000579	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
224915000580	4Fe-4S binding domain; Region: Fer4; cl02805
224915000581	4Fe-4S binding domain; Region: Fer4; pfam00037
224915000582	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
224915000583	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
224915000584	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
224915000585	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
224915000586	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224915000587	NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00204
224915000588	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224915000589	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
224915000590	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224915000591	Integral membrane protein TerC family; Region: TerC; cl10468
224915000592	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
224915000593	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224915000594	Colicin V production protein; Region: Colicin_V; cl00567
224915000595	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
224915000596	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
224915000597	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224915000598	active site
224915000599	peptide chain release factor 1; Validated; Region: prfA; PRK00591
224915000600	This domain is found in peptide chain release factors; Region: PCRF; smart00937
224915000601	RF-1 domain; Region: RF-1; pfam00472
224915000602	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
224915000603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224915000604	S-adenosylmethionine binding site [chemical binding]; other site
224915000605	hypothetical protein; Provisional; Region: PRK10941
224915000606	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
224915000607	Acetokinase family; Region: Acetate_kinase; cl17229
224915000608	propionate/acetate kinase; Provisional; Region: PRK12379
224915000609	phosphate acetyltransferase; Reviewed; Region: PRK05632
224915000610	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
224915000611	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224915000612	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
224915000613	catalytic loop [active]
224915000614	iron binding site [ion binding]; other site
224915000615	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
224915000616	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
224915000617	dimer interface [polypeptide binding]; other site
224915000618	putative radical transfer pathway; other site
224915000619	diiron center [ion binding]; other site
224915000620	tyrosyl radical; other site
224915000621	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
224915000622	ATP cone domain; Region: ATP-cone; pfam03477
224915000623	Class I ribonucleotide reductase; Region: RNR_I; cd01679
224915000624	active site
224915000625	dimer interface [polypeptide binding]; other site
224915000626	catalytic residues [active]
224915000627	effector binding site; other site
224915000628	R2 peptide binding site; other site
224915000629	DNA gyrase subunit A; Validated; Region: PRK05560
224915000630	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
224915000631	CAP-like domain; other site
224915000632	active site
224915000633	primary dimer interface [polypeptide binding]; other site
224915000634	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224915000635	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224915000636	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224915000637	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224915000638	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224915000639	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224915000640	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
224915000641	peroxidase; Provisional; Region: PRK15000
224915000642	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
224915000643	dimer interface [polypeptide binding]; other site
224915000644	decamer (pentamer of dimers) interface [polypeptide binding]; other site
224915000645	catalytic triad [active]
224915000646	peroxidatic and resolving cysteines [active]
224915000647	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
224915000648	ligand binding site [chemical binding]; other site
224915000649	active site
224915000650	UGI interface [polypeptide binding]; other site
224915000651	catalytic site [active]
224915000652	GrpE; Region: GrpE; pfam01025
224915000653	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
224915000654	dimer interface [polypeptide binding]; other site
224915000655	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
224915000656	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
224915000657	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
224915000658	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
224915000659	putative GSH binding site [chemical binding]; other site
224915000660	catalytic residues [active]
224915000661	ribonuclease T; Provisional; Region: PRK05168
224915000662	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
224915000663	active site
224915000664	catalytic site [active]
224915000665	substrate binding site [chemical binding]; other site
224915000666	superoxide dismutase; Provisional; Region: PRK10925
224915000667	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
224915000668	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
224915000669	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
224915000670	putative active site [active]
224915000671	catalytic residue [active]
224915000672	GTP-binding protein YchF; Reviewed; Region: PRK09601
224915000673	YchF GTPase; Region: YchF; cd01900
224915000674	G1 box; other site
224915000675	GTP/Mg2+ binding site [chemical binding]; other site
224915000676	Switch I region; other site
224915000677	G2 box; other site
224915000678	Switch II region; other site
224915000679	G3 box; other site
224915000680	G4 box; other site
224915000681	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
224915000682	threonine synthase; Validated; Region: PRK09225
224915000683	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
224915000684	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224915000685	catalytic residue [active]
224915000686	homoserine kinase; Provisional; Region: PRK01212
224915000687	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
224915000688	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
224915000689	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
224915000690	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
224915000691	putative catalytic residues [active]
224915000692	putative nucleotide binding site [chemical binding]; other site
224915000693	putative aspartate binding site [chemical binding]; other site
224915000694	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
224915000695	dimer interface [polypeptide binding]; other site
224915000696	putative threonine allosteric regulatory site; other site
224915000697	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
224915000698	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
224915000699	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
224915000700	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
224915000701	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
224915000702	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
224915000703	dimerization interface 3.5A [polypeptide binding]; other site
224915000704	active site
224915000705	penicillin-binding protein 1b; Provisional; Region: PRK14850
224915000706	Transglycosylase; Region: Transgly; pfam00912
224915000707	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
224915000708	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
224915000709	DEAD/DEAH box helicase; Region: DEAD; pfam00270
224915000710	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
224915000711	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
224915000712	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
224915000713	active site
224915000714	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
224915000715	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
224915000716	dimer interface [polypeptide binding]; other site
224915000717	TPP-binding site [chemical binding]; other site
224915000718	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
224915000719	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224915000720	E3 interaction surface; other site
224915000721	lipoyl attachment site [posttranslational modification]; other site
224915000722	e3 binding domain; Region: E3_binding; pfam02817
224915000723	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
224915000724	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
224915000725	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
224915000726	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224915000727	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
224915000728	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
224915000729	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
224915000730	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
224915000731	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
224915000732	cell division protein FtsZ; Validated; Region: PRK09330
224915000733	nucleotide binding site [chemical binding]; other site
224915000734	SulA interaction site; other site
224915000735	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
224915000736	Cell division protein FtsA; Region: FtsA; smart00842
224915000737	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224915000738	Cell division protein FtsA; Region: FtsA; pfam14450
224915000739	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
224915000740	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
224915000741	ATP-grasp domain; Region: ATP-grasp_4; cl17255
224915000742	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
224915000743	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224915000744	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224915000745	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224915000746	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
224915000747	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
224915000748	active site
224915000749	homodimer interface [polypeptide binding]; other site
224915000750	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
224915000751	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
224915000752	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224915000753	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224915000754	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
224915000755	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
224915000756	Mg++ binding site [ion binding]; other site
224915000757	putative catalytic motif [active]
224915000758	putative substrate binding site [chemical binding]; other site
224915000759	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
224915000760	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224915000761	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224915000762	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224915000763	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
224915000764	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224915000765	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224915000766	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
224915000767	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224915000768	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224915000769	Cell division protein FtsL; Region: FtsL; cl11433
224915000770	MraW methylase family; Region: Methyltransf_5; cl17771
224915000771	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
224915000772	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
224915000773	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
224915000774	putative valine binding site [chemical binding]; other site
224915000775	dimer interface [polypeptide binding]; other site
224915000776	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
224915000777	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
224915000778	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
224915000779	PYR/PP interface [polypeptide binding]; other site
224915000780	dimer interface [polypeptide binding]; other site
224915000781	TPP binding site [chemical binding]; other site
224915000782	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
224915000783	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
224915000784	TPP-binding site [chemical binding]; other site
224915000785	dimer interface [polypeptide binding]; other site
224915000786	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
224915000787	ApbE family; Region: ApbE; pfam02424
224915000788	serine endoprotease; Provisional; Region: PRK10942
224915000789	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
224915000790	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224915000791	protein binding site [polypeptide binding]; other site
224915000792	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224915000793	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
224915000794	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
224915000795	trimer interface [polypeptide binding]; other site
224915000796	active site
224915000797	substrate binding site [chemical binding]; other site
224915000798	CoA binding site [chemical binding]; other site
224915000799	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
224915000800	active site
224915000801	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
224915000802	rRNA interaction site [nucleotide binding]; other site
224915000803	S8 interaction site; other site
224915000804	putative laminin-1 binding site; other site
224915000805	elongation factor Ts; Provisional; Region: tsf; PRK09377
224915000806	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
224915000807	Elongation factor TS; Region: EF_TS; pfam00889
224915000808	Elongation factor TS; Region: EF_TS; pfam00889
224915000809	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
224915000810	putative nucleotide binding site [chemical binding]; other site
224915000811	uridine monophosphate binding site [chemical binding]; other site
224915000812	homohexameric interface [polypeptide binding]; other site
224915000813	ribosome recycling factor; Reviewed; Region: frr; PRK00083
224915000814	Ribosome recycling factor; Region: RRF; pfam01765
224915000815	hinge region; other site
224915000816	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
224915000817	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
224915000818	catalytic residue [active]
224915000819	putative FPP diphosphate  binding site; other site
224915000820	putative FPP binding hydrophobic cleft; other site
224915000821	dimer interface [polypeptide binding]; other site
224915000822	putative IPP diphosphate binding site; other site
224915000823	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
224915000824	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
224915000825	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
224915000826	putative active site [active]
224915000827	putative PHP Thumb interface [polypeptide binding]; other site
224915000828	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
224915000829	generic binding surface I; other site
224915000830	generic binding surface II; other site
224915000831	prolyl-tRNA synthetase; Provisional; Region: PRK09194
224915000832	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
224915000833	dimer interface [polypeptide binding]; other site
224915000834	motif 1; other site
224915000835	active site
224915000836	motif 2; other site
224915000837	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
224915000838	putative deacylase active site [active]
224915000839	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
224915000840	active site
224915000841	motif 3; other site
224915000842	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
224915000843	anticodon binding site; other site
224915000844	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
224915000845	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
224915000846	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
224915000847	FHIPEP family; Region: FHIPEP; pfam00771
224915000848	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
224915000849	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
224915000850	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
224915000851	active site
224915000852	HIGH motif; other site
224915000853	KMSK motif region; other site
224915000854	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
224915000855	tRNA binding surface [nucleotide binding]; other site
224915000856	anticodon binding site; other site
224915000857	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
224915000858	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
224915000859	RNA/DNA hybrid binding site [nucleotide binding]; other site
224915000860	active site
224915000861	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
224915000862	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
224915000863	active site
224915000864	catalytic site [active]
224915000865	substrate binding site [chemical binding]; other site
224915000866	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224915000867	active site
224915000868	GrpE; Region: GrpE; pfam01025
224915000869	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
224915000870	dimer interface [polypeptide binding]; other site
224915000871	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
224915000872	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
224915000873	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
224915000874	SmpB-tmRNA interface; other site
224915000875	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
224915000876	nucleoside/Zn binding site; other site
224915000877	dimer interface [polypeptide binding]; other site
224915000878	catalytic motif [active]
224915000879	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
224915000880	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
224915000881	GTPase Era; Reviewed; Region: era; PRK00089
224915000882	G1 box; other site
224915000883	GTP/Mg2+ binding site [chemical binding]; other site
224915000884	Switch I region; other site
224915000885	G2 box; other site
224915000886	Switch II region; other site
224915000887	G3 box; other site
224915000888	G4 box; other site
224915000889	G5 box; other site
224915000890	ribonuclease III; Reviewed; Region: rnc; PRK00102
224915000891	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
224915000892	dimerization interface [polypeptide binding]; other site
224915000893	active site
224915000894	metal binding site [ion binding]; metal-binding site
224915000895	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
224915000896	dsRNA binding site [nucleotide binding]; other site
224915000897	signal peptidase I; Provisional; Region: PRK10861
224915000898	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224915000899	Catalytic site [active]
224915000900	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224915000901	GTP-binding protein LepA; Provisional; Region: PRK05433
224915000902	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
224915000903	G1 box; other site
224915000904	putative GEF interaction site [polypeptide binding]; other site
224915000905	GTP/Mg2+ binding site [chemical binding]; other site
224915000906	Switch I region; other site
224915000907	G2 box; other site
224915000908	G3 box; other site
224915000909	Switch II region; other site
224915000910	G4 box; other site
224915000911	G5 box; other site
224915000912	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
224915000913	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
224915000914	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
224915000915	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
224915000916	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
224915000917	Ligand Binding Site [chemical binding]; other site
224915000918	putative lysogenization regulator; Reviewed; Region: PRK00218
224915000919	adenylosuccinate lyase; Provisional; Region: PRK09285
224915000920	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
224915000921	tetramer interface [polypeptide binding]; other site
224915000922	active site
224915000923	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
224915000924	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224915000925	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224915000926	catalytic residue [active]
224915000927	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
224915000928	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
224915000929	NAD binding site [chemical binding]; other site
224915000930	homotetramer interface [polypeptide binding]; other site
224915000931	homodimer interface [polypeptide binding]; other site
224915000932	substrate binding site [chemical binding]; other site
224915000933	active site
224915000934	exoribonuclease II; Provisional; Region: PRK05054
224915000935	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
224915000936	RNB domain; Region: RNB; pfam00773
224915000937	hypothetical protein; Provisional; Region: PRK11111
224915000938	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
224915000939	lipoyl synthase; Provisional; Region: PRK05481
224915000940	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
224915000941	active site
224915000942	dimer interface [polypeptide binding]; other site
224915000943	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
224915000944	dimerization interface [polypeptide binding]; other site
224915000945	active site
224915000946	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
224915000947	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
224915000948	putative active site [active]
224915000949	catalytic site [active]
224915000950	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
224915000951	putative active site [active]
224915000952	catalytic site [active]
224915000953	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
224915000954	Intracellular septation protein A; Region: IspA; pfam04279
224915000955	hypothetical protein; Provisional; Region: PRK02868
224915000956	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
224915000957	substrate binding site [chemical binding]; other site
224915000958	active site
224915000959	catalytic residues [active]
224915000960	heterodimer interface [polypeptide binding]; other site
224915000961	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
224915000962	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
224915000963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224915000964	catalytic residue [active]
224915000965	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
224915000966	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
224915000967	active site
224915000968	ribulose/triose binding site [chemical binding]; other site
224915000969	phosphate binding site [ion binding]; other site
224915000970	substrate (anthranilate) binding pocket [chemical binding]; other site
224915000971	product (indole) binding pocket [chemical binding]; other site
224915000972	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
224915000973	active site
224915000974	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
224915000975	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
224915000976	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
224915000977	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
224915000978	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
224915000979	probable active site [active]
224915000980	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
224915000981	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
224915000982	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
224915000983	tandem repeat interface [polypeptide binding]; other site
224915000984	oligomer interface [polypeptide binding]; other site
224915000985	active site residues [active]
224915000986	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
224915000987	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
224915000988	active site
224915000989	dimerization interface [polypeptide binding]; other site
224915000990	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
224915000991	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224915000992	FeS/SAM binding site; other site
224915000993	histidyl-tRNA synthetase; Region: hisS; TIGR00442
224915000994	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
224915000995	dimer interface [polypeptide binding]; other site
224915000996	motif 1; other site
224915000997	active site
224915000998	motif 2; other site
224915000999	motif 3; other site
224915001000	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
224915001001	anticodon binding site; other site
224915001002	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
224915001003	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
224915001004	dimer interface [polypeptide binding]; other site
224915001005	active site
224915001006	glycine-pyridoxal phosphate binding site [chemical binding]; other site
224915001007	folate binding site [chemical binding]; other site
224915001008	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
224915001009	AAA domain; Region: AAA_26; pfam13500
224915001010	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
224915001011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224915001012	S-adenosylmethionine binding site [chemical binding]; other site
224915001013	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
224915001014	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
224915001015	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224915001016	catalytic residue [active]
224915001017	biotin synthase; Provisional; Region: PRK15108
224915001018	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224915001019	FeS/SAM binding site; other site
224915001020	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
224915001021	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
224915001022	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224915001023	inhibitor-cofactor binding pocket; inhibition site
224915001024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224915001025	catalytic residue [active]
224915001026	6-phosphogluconolactonase; Provisional; Region: PRK11028
224915001027	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
224915001028	DEAD-like helicases superfamily; Region: DEXDc; smart00487
224915001029	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224915001030	ATP binding site [chemical binding]; other site
224915001031	putative Mg++ binding site [ion binding]; other site
224915001032	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224915001033	nucleotide binding region [chemical binding]; other site
224915001034	ATP-binding site [chemical binding]; other site
224915001035	TRCF domain; Region: TRCF; pfam03461
224915001036	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
224915001037	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
224915001038	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
224915001039	flavodoxin FldA; Validated; Region: PRK09267
224915001040	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
224915001041	DNA photolyase; Region: DNA_photolyase; pfam00875
224915001042	Uncharacterized conserved protein [Function unknown]; Region: COG0327
224915001043	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
224915001044	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
224915001045	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
224915001046	TPP-binding site [chemical binding]; other site
224915001047	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
224915001048	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
224915001049	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224915001050	E3 interaction surface; other site
224915001051	lipoyl attachment site [posttranslational modification]; other site
224915001052	e3 binding domain; Region: E3_binding; pfam02817
224915001053	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
224915001054	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
224915001055	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224915001056	ligand binding site [chemical binding]; other site
224915001057	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224915001058	catalytic core [active]
224915001059	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224915001060	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
224915001061	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
224915001062	active site
224915001063	ADP/pyrophosphate binding site [chemical binding]; other site
224915001064	dimerization interface [polypeptide binding]; other site
224915001065	allosteric effector site; other site
224915001066	fructose-1,6-bisphosphate binding site; other site
224915001067	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
224915001068	triosephosphate isomerase; Provisional; Region: PRK14565
224915001069	substrate binding site [chemical binding]; other site
224915001070	dimer interface [polypeptide binding]; other site
224915001071	catalytic triad [active]
224915001072	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
224915001073	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
224915001074	RNA binding site [nucleotide binding]; other site
224915001075	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
224915001076	RNA binding site [nucleotide binding]; other site
224915001077	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
224915001078	RNA binding site [nucleotide binding]; other site
224915001079	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
224915001080	RNA binding site [nucleotide binding]; other site
224915001081	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
224915001082	RNA binding site [nucleotide binding]; other site
224915001083	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224915001084	RNA binding site [nucleotide binding]; other site
224915001085	cytidylate kinase; Provisional; Region: cmk; PRK00023
224915001086	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
224915001087	CMP-binding site; other site
224915001088	The sites determining sugar specificity; other site
224915001089	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
224915001090	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
224915001091	hinge; other site
224915001092	active site
224915001093	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
224915001094	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224915001095	catalytic residue [active]
224915001096	seryl-tRNA synthetase; Provisional; Region: PRK05431
224915001097	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
224915001098	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
224915001099	dimer interface [polypeptide binding]; other site
224915001100	active site
224915001101	motif 1; other site
224915001102	motif 2; other site
224915001103	motif 3; other site
224915001104	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
224915001105	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
224915001106	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224915001107	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
224915001108	rRNA binding site [nucleotide binding]; other site
224915001109	predicted 30S ribosome binding site; other site
224915001110	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
224915001111	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
224915001112	dimer interface [polypeptide binding]; other site
224915001113	anticodon binding site; other site
224915001114	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
224915001115	homodimer interface [polypeptide binding]; other site
224915001116	motif 1; other site
224915001117	active site
224915001118	motif 2; other site
224915001119	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
224915001120	active site
224915001121	motif 3; other site
224915001122	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
224915001123	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224915001124	ABC-ATPase subunit  interface; other site
224915001125	dimer interface [polypeptide binding]; other site
224915001126	putative PBP binding regions; other site
224915001127	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
224915001128	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
224915001129	putative peptidase; Provisional; Region: PRK11649
224915001130	Peptidase family M23; Region: Peptidase_M23; pfam01551
224915001131	pyruvate kinase; Provisional; Region: PRK05826
224915001132	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
224915001133	domain interfaces; other site
224915001134	active site
224915001135	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
224915001136	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
224915001137	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
224915001138	heat shock protein HtpX; Provisional; Region: PRK05457
224915001139	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
224915001140	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
224915001141	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224915001142	Transporter associated domain; Region: CorC_HlyC; smart01091
224915001143	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
224915001144	Glycoprotease family; Region: Peptidase_M22; pfam00814
224915001145	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
224915001146	cell division inhibitor MinD; Provisional; Region: PRK10818
224915001147	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
224915001148	Switch I; other site
224915001149	Switch II; other site
224915001150	septum formation inhibitor; Reviewed; Region: minC; PRK03511
224915001151	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
224915001152	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
224915001153	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
224915001154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224915001155	S-adenosylmethionine binding site [chemical binding]; other site
224915001156	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
224915001157	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
224915001158	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
224915001159	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
224915001160	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224915001161	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12641
224915001162	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
224915001163	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224915001164	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
224915001165	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224915001166	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224915001167	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
224915001168	Flagellar L-ring protein; Region: FlgH; pfam02107
224915001169	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
224915001170	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
224915001171	Rod binding protein; Region: Rod-binding; cl01626
224915001172	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
224915001173	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
224915001174	homodimer interface [polypeptide binding]; other site
224915001175	oligonucleotide binding site [chemical binding]; other site
224915001176	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
224915001177	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
224915001178	RNA binding surface [nucleotide binding]; other site
224915001179	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
224915001180	active site
224915001181	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
224915001182	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
224915001183	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
224915001184	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
224915001185	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
224915001186	NAD(P) binding site [chemical binding]; other site
224915001187	homotetramer interface [polypeptide binding]; other site
224915001188	homodimer interface [polypeptide binding]; other site
224915001189	active site
224915001190	acyl carrier protein; Provisional; Region: acpP; PRK00982
224915001191	thymidylate kinase; Validated; Region: tmk; PRK00698
224915001192	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
224915001193	TMP-binding site; other site
224915001194	ATP-binding site [chemical binding]; other site
224915001195	DNA polymerase III subunit delta'; Validated; Region: PRK07993
224915001196	DNA polymerase III subunit delta'; Validated; Region: PRK08485
224915001197	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
224915001198	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
224915001199	active site
224915001200	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
224915001201	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224915001202	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224915001203	active site turn [active]
224915001204	phosphorylation site [posttranslational modification]
224915001205	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
224915001206	nucleotide binding site/active site [active]
224915001207	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
224915001208	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
224915001209	putative dimer interface [polypeptide binding]; other site
224915001210	putative anticodon binding site; other site
224915001211	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
224915001212	motif 1; other site
224915001213	dimer interface [polypeptide binding]; other site
224915001214	active site
224915001215	motif 2; other site
224915001216	motif 3; other site
224915001217	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
224915001218	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
224915001219	active site residue [active]
224915001220	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
224915001221	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224915001222	active site
224915001223	HIGH motif; other site
224915001224	nucleotide binding site [chemical binding]; other site
224915001225	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
224915001226	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
224915001227	active site
224915001228	KMSKS motif; other site
224915001229	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
224915001230	tRNA binding surface [nucleotide binding]; other site
224915001231	anticodon binding site; other site
224915001232	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
224915001233	multifunctional aminopeptidase A; Provisional; Region: PRK00913
224915001234	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
224915001235	interface (dimer of trimers) [polypeptide binding]; other site
224915001236	Substrate-binding/catalytic site; other site
224915001237	Zn-binding sites [ion binding]; other site
224915001238	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
224915001239	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
224915001240	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
224915001241	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
224915001242	homotrimer interaction site [polypeptide binding]; other site
224915001243	putative active site [active]
224915001244	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
224915001245	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
224915001246	ATP binding site [chemical binding]; other site
224915001247	Mg++ binding site [ion binding]; other site
224915001248	motif III; other site
224915001249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224915001250	nucleotide binding region [chemical binding]; other site
224915001251	ATP-binding site [chemical binding]; other site
224915001252	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
224915001253	putative RNA binding site [nucleotide binding]; other site
224915001254	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
224915001255	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
224915001256	RNase E interface [polypeptide binding]; other site
224915001257	trimer interface [polypeptide binding]; other site
224915001258	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
224915001259	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
224915001260	RNase E interface [polypeptide binding]; other site
224915001261	trimer interface [polypeptide binding]; other site
224915001262	active site
224915001263	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
224915001264	putative nucleic acid binding region [nucleotide binding]; other site
224915001265	G-X-X-G motif; other site
224915001266	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
224915001267	RNA binding site [nucleotide binding]; other site
224915001268	domain interface; other site
224915001269	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
224915001270	16S/18S rRNA binding site [nucleotide binding]; other site
224915001271	S13e-L30e interaction site [polypeptide binding]; other site
224915001272	25S rRNA binding site [nucleotide binding]; other site
224915001273	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
224915001274	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
224915001275	RNA binding site [nucleotide binding]; other site
224915001276	active site
224915001277	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
224915001278	Ribosome-binding factor A; Region: RBFA; pfam02033
224915001279	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
224915001280	translation initiation factor IF-2; Region: IF-2; TIGR00487
224915001281	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
224915001282	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
224915001283	G1 box; other site
224915001284	putative GEF interaction site [polypeptide binding]; other site
224915001285	GTP/Mg2+ binding site [chemical binding]; other site
224915001286	Switch I region; other site
224915001287	G2 box; other site
224915001288	G3 box; other site
224915001289	Switch II region; other site
224915001290	G4 box; other site
224915001291	G5 box; other site
224915001292	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
224915001293	Translation-initiation factor 2; Region: IF-2; pfam11987
224915001294	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
224915001295	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
224915001296	NusA N-terminal domain; Region: NusA_N; pfam08529
224915001297	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
224915001298	RNA binding site [nucleotide binding]; other site
224915001299	homodimer interface [polypeptide binding]; other site
224915001300	NusA-like KH domain; Region: KH_5; pfam13184
224915001301	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
224915001302	G-X-X-G motif; other site
224915001303	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
224915001304	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
224915001305	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
224915001306	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
224915001307	active site
224915001308	substrate binding site [chemical binding]; other site
224915001309	metal binding site [ion binding]; metal-binding site
224915001310	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
224915001311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224915001312	Walker A motif; other site
224915001313	ATP binding site [chemical binding]; other site
224915001314	Walker B motif; other site
224915001315	arginine finger; other site
224915001316	Peptidase family M41; Region: Peptidase_M41; pfam01434
224915001317	FtsJ-like methyltransferase; Region: FtsJ; cl17430
224915001318	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
224915001319	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
224915001320	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
224915001321	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
224915001322	BolA-like protein; Region: BolA; cl00386
224915001323	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
224915001324	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
224915001325	hinge; other site
224915001326	active site
224915001327	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
224915001328	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
224915001329	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
224915001330	GTP1/OBG; Region: GTP1_OBG; pfam01018
224915001331	Obg GTPase; Region: Obg; cd01898
224915001332	G1 box; other site
224915001333	GTP/Mg2+ binding site [chemical binding]; other site
224915001334	Switch I region; other site
224915001335	G2 box; other site
224915001336	G3 box; other site
224915001337	Switch II region; other site
224915001338	G4 box; other site
224915001339	G5 box; other site
224915001340	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
224915001341	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
224915001342	23S rRNA interface [nucleotide binding]; other site
224915001343	L3 interface [polypeptide binding]; other site
224915001344	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
224915001345	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
224915001346	Prephenate dehydratase; Region: PDT; pfam00800
224915001347	signal recognition particle protein; Provisional; Region: PRK10867
224915001348	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
224915001349	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
224915001350	P loop; other site
224915001351	GTP binding site [chemical binding]; other site
224915001352	Signal peptide binding domain; Region: SRP_SPB; pfam02978
224915001353	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
224915001354	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14590
224915001355	RimM N-terminal domain; Region: RimM; pfam01782
224915001356	PRC-barrel domain; Region: PRC; pfam05239
224915001357	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
224915001358	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
224915001359	protease TldD; Provisional; Region: tldD; PRK10735
224915001360	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
224915001361	Dehydroquinase class II; Region: DHquinase_II; pfam01220
224915001362	active site
224915001363	trimer interface [polypeptide binding]; other site
224915001364	dimer interface [polypeptide binding]; other site
224915001365	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
224915001366	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224915001367	RNA binding surface [nucleotide binding]; other site
224915001368	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
224915001369	active site
224915001370	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
224915001371	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
224915001372	motif 1; other site
224915001373	active site
224915001374	motif 2; other site
224915001375	motif 3; other site
224915001376	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
224915001377	carbon storage regulator; Provisional; Region: PRK01712
224915001378	glutamate--cysteine ligase; Provisional; Region: PRK02107
224915001379	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
224915001380	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
224915001381	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
224915001382	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
224915001383	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224915001384	active site
224915001385	dimer interface [polypeptide binding]; other site
224915001386	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
224915001387	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224915001388	active site
224915001389	HIGH motif; other site
224915001390	nucleotide binding site [chemical binding]; other site
224915001391	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224915001392	active site
224915001393	KMSKS motif; other site
224915001394	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
224915001395	CTP synthetase; Validated; Region: pyrG; PRK05380
224915001396	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
224915001397	Catalytic site [active]
224915001398	active site
224915001399	UTP binding site [chemical binding]; other site
224915001400	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
224915001401	active site
224915001402	putative oxyanion hole; other site
224915001403	catalytic triad [active]
224915001404	enolase; Provisional; Region: eno; PRK00077
224915001405	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
224915001406	dimer interface [polypeptide binding]; other site
224915001407	metal binding site [ion binding]; metal-binding site
224915001408	substrate binding pocket [chemical binding]; other site
224915001409	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
224915001410	MutS domain I; Region: MutS_I; pfam01624
224915001411	MutS domain II; Region: MutS_II; pfam05188
224915001412	MutS domain III; Region: MutS_III; pfam05192
224915001413	MutS domain V; Region: MutS_V; pfam00488
224915001414	Walker A/P-loop; other site
224915001415	ATP binding site [chemical binding]; other site
224915001416	Q-loop/lid; other site
224915001417	ABC transporter signature motif; other site
224915001418	Walker B; other site
224915001419	D-loop; other site
224915001420	H-loop/switch region; other site
224915001421	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
224915001422	catalytic residues [active]
224915001423	hinge region; other site
224915001424	alpha helical domain; other site
224915001425	5'-3' exonuclease; Provisional; Region: PRK14976
224915001426	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
224915001427	active site
224915001428	metal binding site 1 [ion binding]; metal-binding site
224915001429	putative 5' ssDNA interaction site; other site
224915001430	metal binding site 3; metal-binding site
224915001431	metal binding site 2 [ion binding]; metal-binding site
224915001432	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
224915001433	putative DNA binding site [nucleotide binding]; other site
224915001434	putative metal binding site [ion binding]; other site
224915001435	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
224915001436	G1 box; other site
224915001437	GTP/Mg2+ binding site [chemical binding]; other site
224915001438	Switch I region; other site
224915001439	G2 box; other site
224915001440	G3 box; other site
224915001441	Switch II region; other site
224915001442	G4 box; other site
224915001443	G5 box; other site
224915001444	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
224915001445	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
224915001446	G1 box; other site
224915001447	putative GEF interaction site [polypeptide binding]; other site
224915001448	GTP/Mg2+ binding site [chemical binding]; other site
224915001449	Switch I region; other site
224915001450	G2 box; other site
224915001451	G3 box; other site
224915001452	Switch II region; other site
224915001453	G4 box; other site
224915001454	G5 box; other site
224915001455	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
224915001456	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
224915001457	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
224915001458	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
224915001459	catalytic site [active]
224915001460	G-X2-G-X-G-K; other site
224915001461	thymidylate synthase; Reviewed; Region: thyA; PRK01827
224915001462	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
224915001463	dimerization interface [polypeptide binding]; other site
224915001464	active site
224915001465	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
224915001466	diaminopimelate decarboxylase; Provisional; Region: PRK11165
224915001467	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
224915001468	active site
224915001469	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224915001470	substrate binding site [chemical binding]; other site
224915001471	catalytic residues [active]
224915001472	dimer interface [polypeptide binding]; other site
224915001473	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
224915001474	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
224915001475	dimer interface [polypeptide binding]; other site
224915001476	putative anticodon binding site; other site
224915001477	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
224915001478	motif 1; other site
224915001479	active site
224915001480	motif 2; other site
224915001481	motif 3; other site
224915001482	peptide chain release factor 2; Validated; Region: prfB; PRK00578
224915001483	This domain is found in peptide chain release factors; Region: PCRF; smart00937
224915001484	RF-1 domain; Region: RF-1; pfam00472
224915001485	putative global regulator; Reviewed; Region: PRK09559
224915001486	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
224915001487	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
224915001488	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224915001489	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224915001490	FeS/SAM binding site; other site
224915001491	TRAM domain; Region: TRAM; pfam01938
224915001492	metal-binding heat shock protein; Provisional; Region: PRK00016
224915001493	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
224915001494	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224915001495	Transporter associated domain; Region: CorC_HlyC; smart01091
224915001496	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
224915001497	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
224915001498	HIGH motif; other site
224915001499	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
224915001500	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224915001501	active site
224915001502	KMSKS motif; other site
224915001503	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
224915001504	tRNA binding surface [nucleotide binding]; other site
224915001505	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
224915001506	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
224915001507	CPxP  motif; other site
224915001508	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
224915001509	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
224915001510	putative antibiotic transporter; Provisional; Region: PRK10739
224915001511	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
224915001512	Phosphoglycerate kinase; Region: PGK; pfam00162
224915001513	substrate binding site [chemical binding]; other site
224915001514	hinge regions; other site
224915001515	ADP binding site [chemical binding]; other site
224915001516	catalytic site [active]
224915001517	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
224915001518	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
224915001519	active site
224915001520	intersubunit interface [polypeptide binding]; other site
224915001521	zinc binding site [ion binding]; other site
224915001522	Na+ binding site [ion binding]; other site
224915001523	mechanosensitive channel MscS; Provisional; Region: PRK10334
224915001524	Mechanosensitive ion channel; Region: MS_channel; pfam00924
224915001525	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
224915001526	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
224915001527	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
224915001528	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
224915001529	AAA domain; Region: AAA_30; pfam13604
224915001530	Family description; Region: UvrD_C_2; pfam13538
224915001531	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
224915001532	homopentamer interface [polypeptide binding]; other site
224915001533	active site
224915001534	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
224915001535	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
224915001536	catalytic motif [active]
224915001537	Zn binding site [ion binding]; other site
224915001538	RibD C-terminal domain; Region: RibD_C; cl17279
224915001539	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
224915001540	putative RNA binding site [nucleotide binding]; other site
224915001541	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224915001542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224915001543	putative substrate translocation pore; other site
224915001544	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
224915001545	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
224915001546	UbiA prenyltransferase family; Region: UbiA; pfam01040
224915001547	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
224915001548	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
224915001549	Subunit I/III interface [polypeptide binding]; other site
224915001550	Subunit III/IV interface [polypeptide binding]; other site
224915001551	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
224915001552	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
224915001553	D-pathway; other site
224915001554	Putative ubiquinol binding site [chemical binding]; other site
224915001555	Low-spin heme (heme b) binding site [chemical binding]; other site
224915001556	Putative water exit pathway; other site
224915001557	Binuclear center (heme o3/CuB) [ion binding]; other site
224915001558	K-pathway; other site
224915001559	Putative proton exit pathway; other site
224915001560	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
224915001561	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
224915001562	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
224915001563	BolA-like protein; Region: BolA; cl00386
224915001564	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
224915001565	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
224915001566	oligomer interface [polypeptide binding]; other site
224915001567	active site residues [active]
224915001568	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
224915001569	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
224915001570	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
224915001571	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224915001572	Walker A motif; other site
224915001573	ATP binding site [chemical binding]; other site
224915001574	Walker B motif; other site
224915001575	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224915001576	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
224915001577	Found in ATP-dependent protease La (LON); Region: LON; smart00464
224915001578	Found in ATP-dependent protease La (LON); Region: LON; smart00464
224915001579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224915001580	Walker A motif; other site
224915001581	ATP binding site [chemical binding]; other site
224915001582	Walker B motif; other site
224915001583	arginine finger; other site
224915001584	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
224915001585	periplasmic folding chaperone; Provisional; Region: PRK10788
224915001586	periplasmic folding chaperone; Provisional; Region: PRK10788
224915001587	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
224915001588	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224915001589	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224915001590	Walker A/P-loop; other site
224915001591	ATP binding site [chemical binding]; other site
224915001592	Q-loop/lid; other site
224915001593	ABC transporter signature motif; other site
224915001594	Walker B; other site
224915001595	D-loop; other site
224915001596	H-loop/switch region; other site
224915001597	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
224915001598	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224915001599	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224915001600	Walker A/P-loop; other site
224915001601	ATP binding site [chemical binding]; other site
224915001602	Q-loop/lid; other site
224915001603	ABC transporter signature motif; other site
224915001604	Walker B; other site
224915001605	D-loop; other site
224915001606	H-loop/switch region; other site
224915001607	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961
224915001608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224915001609	Walker A motif; other site
224915001610	ATP binding site [chemical binding]; other site
224915001611	Walker B motif; other site
224915001612	DNA polymerase III subunit delta'; Validated; Region: PRK08485
224915001613	arginine finger; other site
224915001614	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
224915001615	hypothetical protein; Validated; Region: PRK00153
224915001616	heat shock protein 90; Provisional; Region: PRK05218
224915001617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224915001618	ATP binding site [chemical binding]; other site
224915001619	Mg2+ binding site [ion binding]; other site
224915001620	G-X-G motif; other site
224915001621	adenylate kinase; Reviewed; Region: adk; PRK00279
224915001622	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
224915001623	AMP-binding site [chemical binding]; other site
224915001624	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
224915001625	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
224915001626	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
224915001627	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
224915001628	homodimer interface [polypeptide binding]; other site
224915001629	NADP binding site [chemical binding]; other site
224915001630	substrate binding site [chemical binding]; other site
224915001631	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
224915001632	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
224915001633	active site
224915001634	HIGH motif; other site
224915001635	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224915001636	active site
224915001637	KMSKS motif; other site
224915001638	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
224915001639	tRNA binding surface [nucleotide binding]; other site
224915001640	anticodon binding site; other site
224915001641	hypothetical protein; Provisional; Region: PRK04998
224915001642	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
224915001643	DNA-binding site [nucleotide binding]; DNA binding site
224915001644	RNA-binding motif; other site
224915001645	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
224915001646	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
224915001647	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
224915001648	shikimate binding site; other site
224915001649	NAD(P) binding site [chemical binding]; other site
224915001650	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
224915001651	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
224915001652	active site
224915001653	catalytic residues [active]
224915001654	metal binding site [ion binding]; metal-binding site
224915001655	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
224915001656	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
224915001657	putative active site [active]
224915001658	substrate binding site [chemical binding]; other site
224915001659	putative cosubstrate binding site; other site
224915001660	catalytic site [active]
224915001661	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
224915001662	substrate binding site [chemical binding]; other site
224915001663	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
224915001664	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
224915001665	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
224915001666	alphaNTD homodimer interface [polypeptide binding]; other site
224915001667	alphaNTD - beta interaction site [polypeptide binding]; other site
224915001668	alphaNTD - beta' interaction site [polypeptide binding]; other site
224915001669	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
224915001670	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
224915001671	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
224915001672	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224915001673	RNA binding surface [nucleotide binding]; other site
224915001674	30S ribosomal protein S11; Validated; Region: PRK05309
224915001675	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
224915001676	30S ribosomal protein S13; Region: bact_S13; TIGR03631
224915001677	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
224915001678	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
224915001679	SecY translocase; Region: SecY; pfam00344
224915001680	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
224915001681	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
224915001682	23S rRNA binding site [nucleotide binding]; other site
224915001683	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
224915001684	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
224915001685	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
224915001686	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
224915001687	5S rRNA interface [nucleotide binding]; other site
224915001688	23S rRNA interface [nucleotide binding]; other site
224915001689	L5 interface [polypeptide binding]; other site
224915001690	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
224915001691	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
224915001692	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
224915001693	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
224915001694	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
224915001695	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
224915001696	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
224915001697	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
224915001698	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
224915001699	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
224915001700	RNA binding site [nucleotide binding]; other site
224915001701	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
224915001702	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
224915001703	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
224915001704	putative translocon interaction site; other site
224915001705	signal recognition particle (SRP54) interaction site; other site
224915001706	L23 interface [polypeptide binding]; other site
224915001707	trigger factor interaction site; other site
224915001708	23S rRNA interface [nucleotide binding]; other site
224915001709	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
224915001710	23S rRNA interface [nucleotide binding]; other site
224915001711	5S rRNA interface [nucleotide binding]; other site
224915001712	putative antibiotic binding site [chemical binding]; other site
224915001713	L25 interface [polypeptide binding]; other site
224915001714	L27 interface [polypeptide binding]; other site
224915001715	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
224915001716	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
224915001717	G-X-X-G motif; other site
224915001718	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
224915001719	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
224915001720	protein-rRNA interface [nucleotide binding]; other site
224915001721	putative translocon binding site; other site
224915001722	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
224915001723	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
224915001724	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
224915001725	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
224915001726	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
224915001727	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
224915001728	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
224915001729	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
224915001730	elongation factor Tu; Reviewed; Region: PRK00049
224915001731	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
224915001732	G1 box; other site
224915001733	GEF interaction site [polypeptide binding]; other site
224915001734	GTP/Mg2+ binding site [chemical binding]; other site
224915001735	Switch I region; other site
224915001736	G2 box; other site
224915001737	G3 box; other site
224915001738	Switch II region; other site
224915001739	G4 box; other site
224915001740	G5 box; other site
224915001741	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
224915001742	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
224915001743	Antibiotic Binding Site [chemical binding]; other site
224915001744	elongation factor G; Reviewed; Region: PRK00007
224915001745	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
224915001746	G1 box; other site
224915001747	putative GEF interaction site [polypeptide binding]; other site
224915001748	GTP/Mg2+ binding site [chemical binding]; other site
224915001749	Switch I region; other site
224915001750	G2 box; other site
224915001751	G3 box; other site
224915001752	Switch II region; other site
224915001753	G4 box; other site
224915001754	G5 box; other site
224915001755	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
224915001756	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
224915001757	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
224915001758	30S ribosomal protein S7; Validated; Region: PRK05302
224915001759	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
224915001760	S17 interaction site [polypeptide binding]; other site
224915001761	S8 interaction site; other site
224915001762	16S rRNA interaction site [nucleotide binding]; other site
224915001763	streptomycin interaction site [chemical binding]; other site
224915001764	23S rRNA interaction site [nucleotide binding]; other site
224915001765	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
224915001766	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
224915001767	sulfur relay protein TusC; Validated; Region: PRK00211
224915001768	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
224915001769	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
224915001770	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
224915001771	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
224915001772	putative transporter; Provisional; Region: PRK03699
224915001773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224915001774	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
224915001775	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
224915001776	active site
224915001777	HIGH motif; other site
224915001778	dimer interface [polypeptide binding]; other site
224915001779	KMSKS motif; other site
224915001780	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
224915001781	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
224915001782	substrate binding site [chemical binding]; other site
224915001783	hexamer interface [polypeptide binding]; other site
224915001784	metal binding site [ion binding]; metal-binding site
224915001785	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
224915001786	active site
224915001787	dimer interface [polypeptide binding]; other site
224915001788	metal binding site [ion binding]; metal-binding site
224915001789	shikimate kinase; Reviewed; Region: aroK; PRK00131
224915001790	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
224915001791	ADP binding site [chemical binding]; other site
224915001792	magnesium binding site [ion binding]; other site
224915001793	putative shikimate binding site; other site
224915001794	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
224915001795	phosphopentomutase; Provisional; Region: PRK05362
224915001796	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
224915001797	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
224915001798	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
224915001799	G1 box; other site
224915001800	putative GEF interaction site [polypeptide binding]; other site
224915001801	GTP/Mg2+ binding site [chemical binding]; other site
224915001802	Switch I region; other site
224915001803	G2 box; other site
224915001804	G3 box; other site
224915001805	Switch II region; other site
224915001806	G4 box; other site
224915001807	G5 box; other site
224915001808	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
224915001809	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
224915001810	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
224915001811	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
224915001812	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
224915001813	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
224915001814	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
224915001815	dimer interface [polypeptide binding]; other site
224915001816	ssDNA binding site [nucleotide binding]; other site
224915001817	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224915001818	replicative DNA helicase; Provisional; Region: PRK08006
224915001819	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
224915001820	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
224915001821	Walker A motif; other site
224915001822	ATP binding site [chemical binding]; other site
224915001823	Walker B motif; other site
224915001824	DNA binding loops [nucleotide binding]
224915001825	glutathione synthetase; Provisional; Region: PRK05246
224915001826	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
224915001827	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
224915001828	hypothetical protein; Validated; Region: PRK00228
224915001829	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
224915001830	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
224915001831	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
224915001832	active site
224915001833	catalytic residues [active]
224915001834	metal binding site [ion binding]; metal-binding site
224915001835	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
224915001836	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
224915001837	substrate binding site [chemical binding]; other site
224915001838	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
224915001839	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
224915001840	substrate binding site [chemical binding]; other site
224915001841	ligand binding site [chemical binding]; other site
224915001842	tartrate dehydrogenase; Region: TTC; TIGR02089
224915001843	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
224915001844	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
224915001845	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224915001846	catalytic residue [active]
224915001847	HemN family oxidoreductase; Provisional; Region: PRK05660
224915001848	HemN C-terminal domain; Region: HemN_C; pfam06969
224915001849	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
224915001850	adenine DNA glycosylase; Provisional; Region: PRK10880
224915001851	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224915001852	minor groove reading motif; other site
224915001853	helix-hairpin-helix signature motif; other site
224915001854	substrate binding pocket [chemical binding]; other site
224915001855	active site
224915001856	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
224915001857	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
224915001858	DNA binding and oxoG recognition site [nucleotide binding]
224915001859	Bacterial Fe(2+) trafficking; Region: Iron_traffic; pfam04362
224915001860	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
224915001861	exonuclease I; Provisional; Region: sbcB; PRK11779
224915001862	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
224915001863	active site
224915001864	catalytic site [active]
224915001865	substrate binding site [chemical binding]; other site
224915001866	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
224915001867	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224915001868	active site
224915001869	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
224915001870	trimer interface [polypeptide binding]; other site
224915001871	active site
224915001872	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
224915001873	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
224915001874	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
224915001875	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
224915001876	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
224915001877	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
224915001878	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
224915001879	GDP-binding site [chemical binding]; other site
224915001880	ACT binding site; other site
224915001881	IMP binding site; other site
224915001882	HflC protein; Region: hflC; TIGR01932
224915001883	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
224915001884	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
224915001885	HflK protein; Region: hflK; TIGR01933
224915001886	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
224915001887	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
224915001888	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
224915001889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224915001890	ATP binding site [chemical binding]; other site
224915001891	Mg2+ binding site [ion binding]; other site
224915001892	G-X-G motif; other site
224915001893	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
224915001894	ATP binding site [chemical binding]; other site
224915001895	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
224915001896	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
224915001897	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
224915001898	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
224915001899	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
224915001900	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
224915001901	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
224915001902	active site
224915001903	P-loop; other site
224915001904	phosphorylation site [posttranslational modification]
224915001905	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
224915001906	active site
224915001907	phosphorylation site [posttranslational modification]
224915001908	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
224915001909	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
224915001910	active site
224915001911	dimer interface [polypeptide binding]; other site
224915001912	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
224915001913	dimer interface [polypeptide binding]; other site
224915001914	active site
224915001915	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
224915001916	catalytic site [active]
224915001917	putative active site [active]
224915001918	putative substrate binding site [chemical binding]; other site
224915001919	dimer interface [polypeptide binding]; other site
224915001920	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
224915001921	active site
224915001922	metal binding site [ion binding]; metal-binding site
224915001923	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
224915001924	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
224915001925	active site
224915001926	HslU subunit interaction site [polypeptide binding]; other site
224915001927	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
224915001928	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224915001929	Walker A motif; other site
224915001930	ATP binding site [chemical binding]; other site
224915001931	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224915001932	Walker B motif; other site
224915001933	arginine finger; other site
224915001934	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224915001935	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
224915001936	Glutamine amidotransferase class-I; Region: GATase; pfam00117
224915001937	glutamine binding [chemical binding]; other site
224915001938	catalytic triad [active]
224915001939	anthranilate synthase component I; Provisional; Region: PRK13564
224915001940	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
224915001941	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
224915001942	ferredoxin-NADP reductase; Provisional; Region: PRK10926
224915001943	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
224915001944	FAD binding pocket [chemical binding]; other site
224915001945	FAD binding motif [chemical binding]; other site
224915001946	phosphate binding motif [ion binding]; other site
224915001947	beta-alpha-beta structure motif; other site
224915001948	NAD binding pocket [chemical binding]; other site
224915001949	poxB regulator PoxA; Provisional; Region: PRK09350
224915001950	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
224915001951	motif 1; other site
224915001952	dimer interface [polypeptide binding]; other site
224915001953	active site
224915001954	motif 2; other site
224915001955	motif 3; other site
224915001956	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224915001957	Ligand Binding Site [chemical binding]; other site
224915001958	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
224915001959	Phosphate transporter family; Region: PHO4; pfam01384
224915001960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224915001961	putative substrate translocation pore; other site
224915001962	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224915001963	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
224915001964	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
224915001965	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
224915001966	iron donor protein CyaY; Region: FeS_CyaY; TIGR03421
224915001967	putative iron binding site [ion binding]; other site
224915001968	transcription termination factor Rho; Provisional; Region: rho; PRK09376
224915001969	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
224915001970	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
224915001971	RNA binding site [nucleotide binding]; other site
224915001972	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
224915001973	multimer interface [polypeptide binding]; other site
224915001974	Walker A motif; other site
224915001975	ATP binding site [chemical binding]; other site
224915001976	Walker B motif; other site
224915001977	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224915001978	catalytic residues [active]
224915001979	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
224915001980	Part of AAA domain; Region: AAA_19; pfam13245
224915001981	Family description; Region: UvrD_C_2; pfam13538
224915001982	ketol-acid reductoisomerase; Validated; Region: PRK05225
224915001983	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
224915001984	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
224915001985	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
224915001986	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
224915001987	cysteine desulfurase; Provisional; Region: PRK14012
224915001988	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
224915001989	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224915001990	catalytic residue [active]
224915001991	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
224915001992	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
224915001993	trimerization site [polypeptide binding]; other site
224915001994	active site
224915001995	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224915001996	HSP70 interaction site [polypeptide binding]; other site
224915001997	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
224915001998	nucleotide binding site [chemical binding]; other site
224915001999	putative NEF/HSP70 interaction site [polypeptide binding]; other site
224915002000	SBD interface [polypeptide binding]; other site
224915002001	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224915002002	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
224915002003	catalytic loop [active]
224915002004	iron binding site [ion binding]; other site
224915002005	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
224915002006	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
224915002007	G1 box; other site
224915002008	GTP/Mg2+ binding site [chemical binding]; other site
224915002009	Switch I region; other site
224915002010	G2 box; other site
224915002011	Switch II region; other site
224915002012	G3 box; other site
224915002013	G4 box; other site
224915002014	G5 box; other site
224915002015	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
224915002016	G1 box; other site
224915002017	GTP/Mg2+ binding site [chemical binding]; other site
224915002018	Switch I region; other site
224915002019	G2 box; other site
224915002020	G3 box; other site
224915002021	Switch II region; other site
224915002022	G4 box; other site
224915002023	G5 box; other site
224915002024	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
224915002025	hypothetical protein; Provisional; Region: PRK05208
224915002026	IncFII RepA protein family; Region: IncFII_repA; cl11495
224915002027	IncFII RepA protein family; Region: IncFII_repA; pfam02387