-- dump date 20140619_011926 -- class Genbank::misc_feature -- table misc_feature_note -- id note 713600000001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 713600000002 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 713600000003 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 713600000004 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 713600000005 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 713600000006 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 713600000007 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 713600000008 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 713600000009 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 713600000010 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 713600000011 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 713600000012 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 713600000013 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 713600000014 beta subunit interaction interface [polypeptide binding]; other site 713600000015 Walker A motif; other site 713600000016 ATP binding site [chemical binding]; other site 713600000017 Walker B motif; other site 713600000018 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 713600000019 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 713600000020 core domain interface [polypeptide binding]; other site 713600000021 delta subunit interface [polypeptide binding]; other site 713600000022 epsilon subunit interface [polypeptide binding]; other site 713600000023 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 713600000024 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 713600000025 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 713600000026 alpha subunit interaction interface [polypeptide binding]; other site 713600000027 Walker A motif; other site 713600000028 ATP binding site [chemical binding]; other site 713600000029 Walker B motif; other site 713600000030 inhibitor binding site; inhibition site 713600000031 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 713600000032 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 713600000033 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 713600000034 gamma subunit interface [polypeptide binding]; other site 713600000035 epsilon subunit interface [polypeptide binding]; other site 713600000036 LBP interface [polypeptide binding]; other site 713600000037 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 713600000038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713600000039 ATP binding site [chemical binding]; other site 713600000040 Mg2+ binding site [ion binding]; other site 713600000041 G-X-G motif; other site 713600000042 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 713600000043 anchoring element; other site 713600000044 dimer interface [polypeptide binding]; other site 713600000045 ATP binding site [chemical binding]; other site 713600000046 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 713600000047 active site 713600000048 putative metal-binding site [ion binding]; other site 713600000049 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 713600000050 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 713600000051 DNA polymerase III subunit beta; Validated; Region: PRK05643 713600000052 putative DNA binding surface [nucleotide binding]; other site 713600000053 dimer interface [polypeptide binding]; other site 713600000054 beta-clamp/clamp loader binding surface; other site 713600000055 beta-clamp/translesion DNA polymerase binding surface; other site 713600000056 DnaA N-terminal domain; Region: DnaA_N; pfam11638 713600000057 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 713600000058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713600000059 Walker A motif; other site 713600000060 ATP binding site [chemical binding]; other site 713600000061 Walker B motif; other site 713600000062 arginine finger; other site 713600000063 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 713600000064 DnaA box-binding interface [nucleotide binding]; other site 713600000065 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 713600000066 Ribonuclease P; Region: Ribonuclease_P; cl00457 713600000067 potential frameshift: common BLAST hit: gi|219681959|ref|YP_002468343.1| 60 kDa inner-membrane protein 713600000068 potential frameshift: common BLAST hit: gi|219681403|ref|YP_002467788.1| 60 kDa inner-membrane protein 713600000069 potential frameshift: common BLAST hit: gi|219681959|ref|YP_002468343.1| 60 kDa inner-membrane protein 713600000070 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 713600000071 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 713600000072 trmE is a tRNA modification GTPase; Region: trmE; cd04164 713600000073 G1 box; other site 713600000074 GTP/Mg2+ binding site [chemical binding]; other site 713600000075 Switch I region; other site 713600000076 G2 box; other site 713600000077 Switch II region; other site 713600000078 G3 box; other site 713600000079 G4 box; other site 713600000080 G5 box; other site 713600000081 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 713600000082 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 713600000083 oligomerisation interface [polypeptide binding]; other site 713600000084 mobile loop; other site 713600000085 roof hairpin; other site 713600000086 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713600000087 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713600000088 ring oligomerisation interface [polypeptide binding]; other site 713600000089 ATP/Mg binding site [chemical binding]; other site 713600000090 stacking interactions; other site 713600000091 hinge regions; other site 713600000092 translation elongation factor P; Region: efp; TIGR00038 713600000093 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 713600000094 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 713600000095 RNA binding site [nucleotide binding]; other site 713600000096 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 713600000097 RNA binding site [nucleotide binding]; other site 713600000098 DNA replication protein DnaC; Validated; Region: PRK07952 713600000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713600000100 Walker A motif; other site 713600000101 ATP binding site [chemical binding]; other site 713600000102 Walker B motif; other site 713600000103 potential frameshift: common BLAST hit: gi|219681965|ref|YP_002468349.1| primosomal protein I 713600000104 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 713600000105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713600000106 S-adenosylmethionine binding site [chemical binding]; other site 713600000107 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 713600000108 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 713600000109 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 713600000110 P loop; other site 713600000111 GTP binding site [chemical binding]; other site 713600000112 potential frameshift: common BLAST hit: gi|219681968|ref|YP_002468352.1| RNA polymerase sigma factor 713600000113 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 713600000114 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 713600000115 glutaminase active site [active] 713600000116 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713600000117 dimer interface [polypeptide binding]; other site 713600000118 active site 713600000119 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 713600000120 dimer interface [polypeptide binding]; other site 713600000121 active site 713600000122 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 713600000123 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 713600000124 Substrate binding site; other site 713600000125 Mg++ binding site; other site 713600000126 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 713600000127 active site 713600000128 substrate binding site [chemical binding]; other site 713600000129 CoA binding site [chemical binding]; other site 713600000130 putative hydrolase; Provisional; Region: PRK10976 713600000131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713600000132 active site 713600000133 motif I; other site 713600000134 motif II; other site 713600000135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 713600000136 motif II; other site 713600000137 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 713600000138 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 713600000139 THF binding site; other site 713600000140 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 713600000141 substrate binding site [chemical binding]; other site 713600000142 THF binding site; other site 713600000143 zinc-binding site [ion binding]; other site 713600000144 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 713600000145 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 713600000146 purine monophosphate binding site [chemical binding]; other site 713600000147 dimer interface [polypeptide binding]; other site 713600000148 putative catalytic residues [active] 713600000149 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 713600000150 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 713600000151 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713600000152 IHF dimer interface [polypeptide binding]; other site 713600000153 IHF - DNA interface [nucleotide binding]; other site 713600000154 potential frameshift: common BLAST hit: gi|219681975|ref|YP_002468359.1| DNA-directed RNA polymerase beta' subunit 713600000155 potential frameshift: common BLAST hit: gi|219681975|ref|YP_002468359.1| DNA-directed RNA polymerase beta' subunit 713600000156 potential frameshift: common BLAST hit: gi|219681976|ref|YP_002468360.1| DNA-directed RNA polymerase beta chain 713600000157 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 713600000158 core dimer interface [polypeptide binding]; other site 713600000159 peripheral dimer interface [polypeptide binding]; other site 713600000160 L10 interface [polypeptide binding]; other site 713600000161 L11 interface [polypeptide binding]; other site 713600000162 putative EF-Tu interaction site [polypeptide binding]; other site 713600000163 putative EF-G interaction site [polypeptide binding]; other site 713600000164 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 713600000165 23S rRNA interface [nucleotide binding]; other site 713600000166 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 713600000167 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 713600000168 mRNA/rRNA interface [nucleotide binding]; other site 713600000169 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 713600000170 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 713600000171 23S rRNA interface [nucleotide binding]; other site 713600000172 L7/L12 interface [polypeptide binding]; other site 713600000173 putative thiostrepton binding site; other site 713600000174 L25 interface [polypeptide binding]; other site 713600000175 potential frameshift: common BLAST hit: gi|219681981|ref|YP_002468365.1| transcription antitermination protein NusG 713600000176 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 713600000177 potential frameshift: common BLAST hit: gi|219681983|ref|YP_002468367.1| UDP-N-acetylenolpyruvoylglucosamine reductase 713600000178 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 713600000179 FAD binding site [chemical binding]; other site 713600000180 acetylornithine deacetylase; Provisional; Region: PRK05111 713600000181 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 713600000182 metal binding site [ion binding]; metal-binding site 713600000183 putative dimer interface [polypeptide binding]; other site 713600000184 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 713600000185 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 713600000186 potential frameshift: common BLAST hit: gi|219681431|ref|YP_002467816.1| acetylglutamate kinase 713600000187 argininosuccinate synthase; Provisional; Region: PRK13820 713600000188 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 713600000189 ANP binding site [chemical binding]; other site 713600000190 Substrate Binding Site II [chemical binding]; other site 713600000191 Substrate Binding Site I [chemical binding]; other site 713600000192 argininosuccinate lyase; Provisional; Region: PRK04833 713600000193 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 713600000194 active sites [active] 713600000195 tetramer interface [polypeptide binding]; other site 713600000196 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 713600000197 active site residue [active] 713600000198 Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952 713600000199 SecA binding site; other site 713600000200 Preprotein binding site; other site 713600000201 serine acetyltransferase; Provisional; Region: cysE; PRK11132 713600000202 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 713600000203 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 713600000204 trimer interface [polypeptide binding]; other site 713600000205 active site 713600000206 substrate binding site [chemical binding]; other site 713600000207 CoA binding site [chemical binding]; other site 713600000208 potential frameshift: common BLAST hit: gi|219681993|ref|YP_002468377.1| RNA polymerase sigma factor 713600000209 potential frameshift: common BLAST hit: gi|219681437|ref|YP_002467822.1| RNA polymerase sigma factor 713600000210 potential frameshift: common BLAST hit: gi|219681994|ref|YP_002468378.1| DNA primase 713600000211 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 713600000212 UGMP family protein; Validated; Region: PRK09604 713600000213 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 713600000214 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 713600000215 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 713600000216 potential frameshift: common BLAST hit: gi|219681998|ref|YP_002468382.1| kinase 713600000217 potential frameshift: common BLAST hit: gi|219681999|ref|YP_002468383.1| tRNA nucleotidyltransferase 713600000218 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 713600000219 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 713600000220 HPr interaction site; other site 713600000221 glycerol kinase (GK) interaction site [polypeptide binding]; other site 713600000222 active site 713600000223 phosphorylation site [posttranslational modification] 713600000224 potential frameshift: common BLAST hit: gi|219682002|ref|YP_002468386.1| phosphoenolpyruvate-protein phosphotransferase 713600000225 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 713600000226 dimerization domain swap beta strand [polypeptide binding]; other site 713600000227 regulatory protein interface [polypeptide binding]; other site 713600000228 active site 713600000229 regulatory phosphorylation site [posttranslational modification]; other site 713600000230 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 713600000231 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713600000232 dimer interface [polypeptide binding]; other site 713600000233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713600000234 catalytic residue [active] 713600000235 potential frameshift: common BLAST hit: gi|15616692|ref|NP_239904.1| DNA ligase (NAD+) 713600000236 potential frameshift: common BLAST hit: gi|219681449|ref|YP_002467834.1| DNA ligase (NAD+) 713600000237 potential frameshift: common BLAST hit: gi|219682005|ref|YP_002468389.1| DNA ligase (NAD+) 713600000238 potential frameshift: common BLAST hit: gi|219681450|ref|YP_002467835.1| glutamyl-tRNA synthetase 713600000239 Flagellar hook-basal body protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliE; COG1677 713600000240 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 713600000241 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 713600000242 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 713600000243 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 713600000244 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 713600000245 FliG C-terminal domain; Region: FliG_C; pfam01706 713600000246 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 713600000247 Flagellar assembly protein FliH; Region: FliH; pfam02108 713600000248 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 713600000249 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713600000250 Walker A motif; other site 713600000251 ATP binding site [chemical binding]; other site 713600000252 Walker B motif; other site 713600000253 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 713600000254 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 713600000255 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 713600000256 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 713600000257 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 713600000258 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 713600000259 putative bifunctional flagellar biosynthesis protein FliO/FliP; Provisional; Region: PRK12430 713600000260 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 713600000261 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 713600000262 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 713600000263 potential frameshift: common BLAST hit: gi|219682018|ref|YP_002468402.1| flagellar biosynthetic protein FliR 713600000264 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 713600000265 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 713600000266 potential frameshift: common BLAST hit: gi|219682022|ref|YP_002468406.1| inorganic pyrophosphatase 713600000267 peptidase PmbA; Provisional; Region: PRK11040 713600000268 Predicted methyltransferases [General function prediction only]; Region: COG0313 713600000269 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 713600000270 putative SAM binding site [chemical binding]; other site 713600000271 putative homodimer interface [polypeptide binding]; other site 713600000272 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 713600000273 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713600000274 dimer interface [polypeptide binding]; other site 713600000275 active site 713600000276 potential frameshift: common BLAST hit: gi|219682025|ref|YP_002468409.1| transaldolase 713600000277 transketolase; Reviewed; Region: PRK12753 713600000278 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 713600000279 TPP-binding site [chemical binding]; other site 713600000280 dimer interface [polypeptide binding]; other site 713600000281 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713600000282 PYR/PP interface [polypeptide binding]; other site 713600000283 dimer interface [polypeptide binding]; other site 713600000284 TPP binding site [chemical binding]; other site 713600000285 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713600000286 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 713600000287 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 713600000288 metal binding site [ion binding]; metal-binding site 713600000289 dimer interface [polypeptide binding]; other site 713600000290 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 713600000291 dihydrodipicolinate synthase; Region: dapA; TIGR00674 713600000292 dimer interface [polypeptide binding]; other site 713600000293 active site 713600000294 catalytic residue [active] 713600000295 potential frameshift: common BLAST hit: gi|219682029|ref|YP_002468413.1| chorismate synthase 713600000296 hypothetical protein; Provisional; Region: PRK04946 713600000297 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 713600000298 Smr domain; Region: Smr; pfam01713 713600000299 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 713600000300 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 713600000301 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 713600000302 potential frameshift: common BLAST hit: gi|219682032|ref|YP_002468416.1| histidinol-dehydrogenase 713600000303 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 713600000304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713600000305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713600000306 homodimer interface [polypeptide binding]; other site 713600000307 catalytic residue [active] 713600000308 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 713600000309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713600000310 active site 713600000311 motif I; other site 713600000312 motif II; other site 713600000313 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 713600000314 putative active site pocket [active] 713600000315 4-fold oligomerization interface [polypeptide binding]; other site 713600000316 metal binding residues [ion binding]; metal-binding site 713600000317 3-fold/trimer interface [polypeptide binding]; other site 713600000318 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 713600000319 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 713600000320 putative active site [active] 713600000321 oxyanion strand; other site 713600000322 catalytic triad [active] 713600000323 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 713600000324 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 713600000325 catalytic residues [active] 713600000326 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 713600000327 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 713600000328 substrate binding site [chemical binding]; other site 713600000329 glutamase interaction surface [polypeptide binding]; other site 713600000330 potential frameshift: common BLAST hit: gi|219682038|ref|YP_002468422.1| phosphoribosyl-AMP cyclohydrolase 713600000331 potential frameshift: common BLAST hit: gi|219681483|ref|YP_002467868.1| 6-phosphogluconate dehydrogenase 713600000332 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 713600000333 trimer interface [polypeptide binding]; other site 713600000334 active site 713600000335 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 713600000336 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 713600000337 active site 713600000338 HIGH motif; other site 713600000339 KMSKS motif; other site 713600000340 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 713600000341 tRNA binding surface [nucleotide binding]; other site 713600000342 anticodon binding site; other site 713600000343 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 713600000344 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 713600000345 Ligand Binding Site [chemical binding]; other site 713600000346 TilS substrate binding domain; Region: TilS; pfam09179 713600000347 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 713600000348 Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307 713600000349 Lumazine binding domain; Region: Lum_binding; pfam00677 713600000350 Lumazine binding domain; Region: Lum_binding; pfam00677 713600000351 electron transport complex protein RsxA; Provisional; Region: PRK05151 713600000352 ferredoxin; Provisional; Region: PRK08764 713600000353 Putative Fe-S cluster; Region: FeS; pfam04060 713600000354 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 713600000355 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 713600000356 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 713600000357 potential frameshift: common BLAST hit: gi|219682047|ref|YP_002468431.1| integral membrane protein of SoxR-reducing complex (YdgO) 713600000358 potential frameshift: common BLAST hit: gi|219682047|ref|YP_002468431.1| integral membrane protein of SoxR-reducing complex (YdgO) 713600000359 Predicted NADH:ubiquinone oxidoreductase, subunit RnfG [Energy production and conversion]; Region: RnfG; COG4659 713600000360 electron transport complex RsxE subunit; Provisional; Region: PRK12405 713600000361 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 713600000362 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 713600000363 minor groove reading motif; other site 713600000364 helix-hairpin-helix signature motif; other site 713600000365 substrate binding pocket [chemical binding]; other site 713600000366 active site 713600000367 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 713600000368 potential frameshift: common BLAST hit: gi|219682051|ref|YP_002468435.1| primosomal protein N' 713600000369 potential frameshift: common BLAST hit: gi|219682051|ref|YP_002468435.1| primosomal protein N' 713600000370 potential frameshift: common BLAST hit: gi|219681496|ref|YP_002467881.1| tyrosyl-tRNA synthetase 713600000371 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 713600000372 potential frameshift: common BLAST hit: gi|15616743|ref|NP_239955.1| putative inner membrane protein 713600000373 potential frameshift: common BLAST hit: gi|219682055|ref|YP_002468439.1| 3-deoxy-7-phosphoheptulonate synthase 713600000374 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 713600000375 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 713600000376 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 713600000377 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 713600000378 active site 713600000379 dimer interface [polypeptide binding]; other site 713600000380 motif 1; other site 713600000381 motif 2; other site 713600000382 motif 3; other site 713600000383 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 713600000384 anticodon binding site; other site 713600000385 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 713600000386 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 713600000387 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 713600000388 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 713600000389 23S rRNA binding site [nucleotide binding]; other site 713600000390 L21 binding site [polypeptide binding]; other site 713600000391 L13 binding site [polypeptide binding]; other site 713600000392 potential frameshift: common BLAST hit: gi|219682060|ref|YP_002468444.1| phenylalanyl-tRNA synthetase alpha chain 713600000393 potential frameshift: common BLAST hit: gi|219682060|ref|YP_002468444.1| phenylalanyl-tRNA synthetase alpha chain 713600000394 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 713600000395 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 713600000396 putative tRNA-binding site [nucleotide binding]; other site 713600000397 B3/4 domain; Region: B3_4; pfam03483 713600000398 tRNA synthetase B5 domain; Region: B5; smart00874 713600000399 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 713600000400 dimer interface [polypeptide binding]; other site 713600000401 motif 1; other site 713600000402 motif 3; other site 713600000403 motif 2; other site 713600000404 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 713600000405 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713600000406 IHF - DNA interface [nucleotide binding]; other site 713600000407 IHF dimer interface [polypeptide binding]; other site 713600000408 potential frameshift: common BLAST hit: gi|219681507|ref|YP_002467892.1| S-adenosylmethionine:tRNA ribosyltransferase-isomerase 713600000409 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 713600000410 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 713600000411 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 713600000412 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 713600000413 potential frameshift: common BLAST hit: gi|219682067|ref|YP_002468451.1| glycyl-tRNA synthetase alpha subunit 713600000414 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 713600000415 AP (apurinic/apyrimidinic) site pocket; other site 713600000416 endonuclease IV; Provisional; Region: PRK01060 713600000417 DNA interaction; other site 713600000418 Metal-binding active site; metal-binding site 713600000419 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 713600000420 5S rRNA interface [nucleotide binding]; other site 713600000421 CTC domain interface [polypeptide binding]; other site 713600000422 L16 interface [polypeptide binding]; other site 713600000423 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713600000424 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713600000425 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 713600000426 SurA N-terminal domain; Region: SurA_N; pfam09312 713600000427 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 713600000428 potential frameshift: common BLAST hit: gi|219681516|ref|YP_002467901.1| dimethyladenosine transferase 713600000429 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 713600000430 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 713600000431 active site 713600000432 metal binding site [ion binding]; metal-binding site 713600000433 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713600000434 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 713600000435 folate binding site [chemical binding]; other site 713600000436 NADP+ binding site [chemical binding]; other site 713600000437 potential frameshift: common BLAST hit: gi|219681519|ref|YP_002467904.1| carbamoyl-phosphate synthase large chain 713600000438 potential frameshift: common BLAST hit: gi|219681519|ref|YP_002467904.1| carbamoyl-phosphate synthase large chain 713600000439 potential frameshift: common BLAST hit: gi|219682076|ref|YP_002468460.1| carbamoyl-phosphate synthase small subunit 713600000440 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 713600000441 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 713600000442 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 713600000443 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 713600000444 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 713600000445 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 713600000446 potential frameshift: common BLAST hit: gi|15616769|ref|NP_239981.1| isoleucyl-tRNA synthetase 713600000447 potential frameshift: common BLAST hit: gi|219682080|ref|YP_002468464.1| isoleucyl-tRNA synthetase 713600000448 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 713600000449 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 713600000450 active site 713600000451 Riboflavin kinase; Region: Flavokinase; smart00904 713600000452 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 713600000453 potential frameshift: common BLAST hit: gi|219681527|ref|YP_002467912.1| DnaJ protein 713600000454 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 713600000455 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713600000456 nucleotide binding site [chemical binding]; other site 713600000457 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 713600000458 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 713600000459 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 713600000460 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 713600000461 NADH dehydrogenase subunit D; Validated; Region: PRK06075 713600000462 potential frameshift: common BLAST hit: gi|219682088|ref|YP_002468472.1| ATP synthase subunit E 713600000463 potential frameshift: common BLAST hit: gi|219681533|ref|YP_002467918.1| NADH dehydrogenase I chain F 713600000464 potential frameshift: common BLAST hit: gi|219682089|ref|YP_002468473.1| NADH dehydrogenase I chain F 713600000465 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 713600000466 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713600000467 catalytic loop [active] 713600000468 iron binding site [ion binding]; other site 713600000469 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 713600000470 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 713600000471 [4Fe-4S] binding site [ion binding]; other site 713600000472 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 713600000473 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 713600000474 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 713600000475 4Fe-4S binding domain; Region: Fer4; pfam00037 713600000476 4Fe-4S binding domain; Region: Fer4; pfam00037 713600000477 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 713600000478 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 713600000479 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 713600000480 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 713600000481 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 713600000482 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 713600000483 potential frameshift: common BLAST hit: gi|219682096|ref|YP_002468480.1| NADH dehydrogenase I chain M 713600000484 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 713600000485 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 713600000486 potential frameshift: common BLAST hit: gi|219681542|ref|YP_002467927.1| dihydrofolate synthase 713600000487 potential frameshift: common BLAST hit: gi|219681542|ref|YP_002467927.1| dihydrofolate synthase 713600000488 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 713600000489 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 713600000490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713600000491 active site 713600000492 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 713600000493 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 713600000494 potential frameshift: common BLAST hit: gi|219682101|ref|YP_002468485.1| peptide chain release factor 1 713600000495 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 713600000496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713600000497 S-adenosylmethionine binding site [chemical binding]; other site 713600000498 hypothetical protein; Provisional; Region: PRK10941 713600000499 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 713600000500 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 713600000501 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 713600000502 homodimer interface [polypeptide binding]; other site 713600000503 NAD binding pocket [chemical binding]; other site 713600000504 ATP binding pocket [chemical binding]; other site 713600000505 Mg binding site [ion binding]; other site 713600000506 active-site loop [active] 713600000507 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 713600000508 propionate/acetate kinase; Provisional; Region: PRK12379 713600000509 potential frameshift: common BLAST hit: gi|219682106|ref|YP_002468490.1| phosphate acetyltransferase 713600000510 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 713600000511 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713600000512 catalytic loop [active] 713600000513 iron binding site [ion binding]; other site 713600000514 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 713600000515 dimer interface [polypeptide binding]; other site 713600000516 putative radical transfer pathway; other site 713600000517 diiron center [ion binding]; other site 713600000518 tyrosyl radical; other site 713600000519 potential frameshift: common BLAST hit: gi|219682109|ref|YP_002468493.1| ribonucleotide-diphosphate reductase alpha subunit 713600000520 potential frameshift: common BLAST hit: gi|15616799|ref|NP_240011.1| DNA gyrase subunit A 713600000521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 713600000522 peroxidase; Provisional; Region: PRK15000 713600000523 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 713600000524 dimer interface [polypeptide binding]; other site 713600000525 decamer (pentamer of dimers) interface [polypeptide binding]; other site 713600000526 catalytic triad [active] 713600000527 peroxidatic and resolving cysteines [active] 713600000528 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 713600000529 ligand binding site [chemical binding]; other site 713600000530 active site 713600000531 UGI interface [polypeptide binding]; other site 713600000532 catalytic site [active] 713600000533 potential frameshift: common BLAST hit: gi|219682114|ref|YP_002468498.1| heat shock protein GrpE2 713600000534 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 713600000535 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 713600000536 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 713600000537 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 713600000538 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 713600000539 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 713600000540 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 713600000541 putative GSH binding site [chemical binding]; other site 713600000542 catalytic residues [active] 713600000543 ribonuclease T; Provisional; Region: PRK05168 713600000544 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 713600000545 active site 713600000546 catalytic site [active] 713600000547 substrate binding site [chemical binding]; other site 713600000548 superoxide dismutase; Provisional; Region: PRK10925 713600000549 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 713600000550 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 713600000551 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 713600000552 putative active site [active] 713600000553 catalytic residue [active] 713600000554 GTP-binding protein YchF; Reviewed; Region: PRK09601 713600000555 YchF GTPase; Region: YchF; cd01900 713600000556 G1 box; other site 713600000557 GTP/Mg2+ binding site [chemical binding]; other site 713600000558 Switch I region; other site 713600000559 G2 box; other site 713600000560 Switch II region; other site 713600000561 G3 box; other site 713600000562 G4 box; other site 713600000563 G5 box; other site 713600000564 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 713600000565 threonine synthase; Validated; Region: PRK09225 713600000566 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 713600000567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713600000568 catalytic residue [active] 713600000569 potential frameshift: common BLAST hit: gi|219682123|ref|YP_002468507.1| homoserine kinase 713600000570 potential frameshift: common BLAST hit: gi|219682124|ref|YP_002468508.1| bifunctional aspartokinase I/homeserine dehydrogenase I 713600000571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713600000572 active site 713600000573 pantoate--beta-alanine ligase; Region: panC; TIGR00018 713600000574 Pantoate-beta-alanine ligase; Region: PanC; cd00560 713600000575 active site 713600000576 ATP-binding site [chemical binding]; other site 713600000577 pantoate-binding site; other site 713600000578 HXXH motif; other site 713600000579 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 713600000580 oligomerization interface [polypeptide binding]; other site 713600000581 active site 713600000582 metal binding site [ion binding]; metal-binding site 713600000583 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 713600000584 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 713600000585 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 713600000586 dimerization interface 3.5A [polypeptide binding]; other site 713600000587 active site 713600000588 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 713600000589 Transglycosylase; Region: Transgly; pfam00912 713600000590 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713600000591 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 713600000592 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 713600000593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 713600000594 nucleotide binding region [chemical binding]; other site 713600000595 ATP-binding site [chemical binding]; other site 713600000596 SEC-C motif; Region: SEC-C; pfam02810 713600000597 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 713600000598 dephospho-CoA kinase; Region: TIGR00152 713600000599 CoA-binding site [chemical binding]; other site 713600000600 ATP-binding [chemical binding]; other site 713600000601 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 713600000602 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 713600000603 active site 713600000604 potential frameshift: common BLAST hit: gi|219682135|ref|YP_002468519.1| pyruvate dehydrogenase E1 component 713600000605 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 713600000606 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713600000607 E3 interaction surface; other site 713600000608 lipoyl attachment site [posttranslational modification]; other site 713600000609 e3 binding domain; Region: E3_binding; pfam02817 713600000610 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713600000611 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 713600000612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713600000613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713600000614 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713600000615 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 713600000616 potential frameshift: common BLAST hit: gi|219682139|ref|YP_002468523.1| spermidine synthase 713600000617 potential frameshift: common BLAST hit: gi|219682140|ref|YP_002468524.1| 5'-methylthioadenosine nucleosidase 713600000618 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 713600000619 cell division protein FtsZ; Validated; Region: PRK09330 713600000620 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 713600000621 nucleotide binding site [chemical binding]; other site 713600000622 SulA interaction site; other site 713600000623 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 713600000624 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713600000625 nucleotide binding site [chemical binding]; other site 713600000626 Cell division protein FtsA; Region: FtsA; pfam14450 713600000627 potential frameshift: common BLAST hit: gi|21672494|ref|NP_660561.1| D-alanine--D-alanine ligase 713600000628 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 713600000629 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 713600000630 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713600000631 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713600000632 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 713600000633 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 713600000634 active site 713600000635 homodimer interface [polypeptide binding]; other site 713600000636 potential frameshift: common BLAST hit: gi|219681588|ref|YP_002467974.1| cell division protein FtsW 713600000637 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 713600000638 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713600000639 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713600000640 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 713600000641 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 713600000642 Mg++ binding site [ion binding]; other site 713600000643 putative catalytic motif [active] 713600000644 putative substrate binding site [chemical binding]; other site 713600000645 potential frameshift: common BLAST hit: gi|15616838|ref|NP_240050.1| UDP-N-acetylmuramoylalanyl-D-glutamyl-2 713600000646 potential frameshift: common BLAST hit: gi|219681591|ref|YP_002467977.1| UDP-N-acetylmuramoylalanyl-D-glutamyl-2 713600000647 potential frameshift: common BLAST hit: gi|219682149|ref|YP_002468533.1| UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase 713600000648 potential frameshift: common BLAST hit: gi|219682150|ref|YP_002468534.1| cell division protein FtsI 713600000649 potential frameshift: common BLAST hit: gi|219682151|ref|YP_002468535.1| cell division protein 713600000650 MraW methylase family; Region: Methyltransf_5; cl17771 713600000651 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 713600000652 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 713600000653 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 713600000654 putative valine binding site [chemical binding]; other site 713600000655 dimer interface [polypeptide binding]; other site 713600000656 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 713600000657 potential frameshift: common BLAST hit: gi|219682154|ref|YP_002468538.1| acetolactate synthase large subunit 713600000658 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 713600000659 ApbE family; Region: ApbE; pfam02424 713600000660 serine endoprotease; Provisional; Region: PRK10942 713600000661 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713600000662 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713600000663 protein binding site [polypeptide binding]; other site 713600000664 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713600000665 protein binding site [polypeptide binding]; other site 713600000666 potential frameshift: common BLAST hit: gi|219681599|ref|YP_002467985.1| 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase 713600000667 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 713600000668 active site 713600000669 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 713600000670 rRNA interaction site [nucleotide binding]; other site 713600000671 S8 interaction site; other site 713600000672 putative laminin-1 binding site; other site 713600000673 potential frameshift: common BLAST hit: gi|219682159|ref|YP_002468543.1| elongation factor Ts 713600000674 potential frameshift: common BLAST hit: gi|219682160|ref|YP_002468544.1| uridylate kinase 713600000675 ribosome recycling factor; Reviewed; Region: frr; PRK00083 713600000676 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 713600000677 hinge region; other site 713600000678 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 713600000679 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 713600000680 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 713600000681 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 713600000682 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 713600000683 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 713600000684 catalytic residue [active] 713600000685 putative FPP diphosphate binding site; other site 713600000686 putative FPP binding hydrophobic cleft; other site 713600000687 dimer interface [polypeptide binding]; other site 713600000688 putative IPP diphosphate binding site; other site 713600000689 potential frameshift: common BLAST hit: gi|219682164|ref|YP_002468548.1| YaeT 713600000690 potential frameshift: common BLAST hit: gi|219682164|ref|YP_002468548.1| YaeT 713600000691 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 713600000692 potential frameshift: common BLAST hit: gi|219682166|ref|YP_002468550.1| DNA polymerase III alpha chain 713600000693 potential frameshift: common BLAST hit: gi|219681609|ref|YP_002467995.1| DNA polymerase III alpha chain 713600000694 prolyl-tRNA synthetase; Provisional; Region: PRK09194 713600000695 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 713600000696 dimer interface [polypeptide binding]; other site 713600000697 motif 1; other site 713600000698 active site 713600000699 motif 2; other site 713600000700 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 713600000701 putative deacylase active site [active] 713600000702 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713600000703 active site 713600000704 motif 3; other site 713600000705 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 713600000706 anticodon binding site; other site 713600000707 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 713600000708 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 713600000709 potential frameshift: common BLAST hit: gi|219682169|ref|YP_002468553.1| flagellar biosynthetic protein FlhA 713600000710 potential frameshift: common BLAST hit: gi|219682169|ref|YP_002468553.1| flagellar biosynthetic protein FlhA 713600000711 potential frameshift: common BLAST hit: gi|219682170|ref|YP_002468554.1| arginyl-tRNA synthetase 713600000712 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 713600000713 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 713600000714 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 713600000715 active site 713600000716 RNA/DNA hybrid binding site [nucleotide binding]; other site 713600000717 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 713600000718 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 713600000719 active site 713600000720 catalytic site [active] 713600000721 substrate binding site [chemical binding]; other site 713600000722 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 713600000723 dimer interface [polypeptide binding]; other site 713600000724 active site 713600000725 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713600000726 active site 713600000727 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 713600000728 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 713600000729 dimer interface [polypeptide binding]; other site 713600000730 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 713600000731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 713600000732 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 713600000733 SmpB-tmRNA interface; other site 713600000734 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713600000735 nucleoside/Zn binding site; other site 713600000736 dimer interface [polypeptide binding]; other site 713600000737 catalytic motif [active] 713600000738 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 713600000739 GTPase [General function prediction only]; Region: Era; COG1159 713600000740 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 713600000741 G1 box; other site 713600000742 GTP/Mg2+ binding site [chemical binding]; other site 713600000743 Switch I region; other site 713600000744 G2 box; other site 713600000745 Switch II region; other site 713600000746 G3 box; other site 713600000747 G4 box; other site 713600000748 G5 box; other site 713600000749 ribonuclease III; Reviewed; Region: rnc; PRK00102 713600000750 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 713600000751 dimerization interface [polypeptide binding]; other site 713600000752 active site 713600000753 metal binding site [ion binding]; metal-binding site 713600000754 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 713600000755 dsRNA binding site [nucleotide binding]; other site 713600000756 potential frameshift: common BLAST hit: gi|219682182|ref|YP_002468566.1| signal peptidase I 713600000757 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 713600000758 GTP-binding protein LepA; Provisional; Region: PRK05433 713600000759 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 713600000760 G1 box; other site 713600000761 putative GEF interaction site [polypeptide binding]; other site 713600000762 GTP/Mg2+ binding site [chemical binding]; other site 713600000763 Switch I region; other site 713600000764 G2 box; other site 713600000765 G3 box; other site 713600000766 Switch II region; other site 713600000767 G4 box; other site 713600000768 G5 box; other site 713600000769 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 713600000770 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 713600000771 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 713600000772 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 713600000773 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 713600000774 Ligand Binding Site [chemical binding]; other site 713600000775 Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915 713600000776 potential frameshift: common BLAST hit: gi|219681629|ref|YP_002468015.1| adenylosuccinate lyase 713600000777 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713600000778 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713600000779 catalytic residue [active] 713600000780 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 713600000781 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 713600000782 NAD binding site [chemical binding]; other site 713600000783 homotetramer interface [polypeptide binding]; other site 713600000784 homodimer interface [polypeptide binding]; other site 713600000785 substrate binding site [chemical binding]; other site 713600000786 active site 713600000787 Exoribonuclease II [Transcription]; Region: Rnb; COG4776 713600000788 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 713600000789 RNB domain; Region: RNB; pfam00773 713600000790 hypothetical protein; Provisional; Region: PRK11111 713600000791 potential frameshift: common BLAST hit: gi|219682191|ref|YP_002468575.1| lipoate-protein ligase B 713600000792 potential frameshift: common BLAST hit: gi|15616880|ref|NP_240093.1| lipoyl synthase 713600000793 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 713600000794 active site 713600000795 dimer interface [polypeptide binding]; other site 713600000796 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713600000797 dimerization interface [polypeptide binding]; other site 713600000798 active site 713600000799 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 713600000800 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 713600000801 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 713600000802 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 713600000803 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 713600000804 putative active site [active] 713600000805 catalytic site [active] 713600000806 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 713600000807 putative active site [active] 713600000808 catalytic site [active] 713600000809 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 713600000810 Intracellular septation protein A [Cell division and chromosome partitioning]; Region: COG2917 713600000811 potential frameshift: common BLAST hit: gi|219681642|ref|YP_002468028.1| predicted inner membrane protein (YciC) 713600000812 potential frameshift: common BLAST hit: gi|219682200|ref|YP_002468584.1| tryptophan synthase alpha chain 713600000813 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 713600000814 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 713600000815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713600000816 catalytic residue [active] 713600000817 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 713600000818 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 713600000819 active site 713600000820 ribulose/triose binding site [chemical binding]; other site 713600000821 phosphate binding site [ion binding]; other site 713600000822 substrate (anthranilate) binding pocket [chemical binding]; other site 713600000823 product (indole) binding pocket [chemical binding]; other site 713600000824 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 713600000825 active site 713600000826 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 713600000827 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 713600000828 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 713600000829 EamA-like transporter family; Region: EamA; pfam00892 713600000830 EamA-like transporter family; Region: EamA; pfam00892 713600000831 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 713600000832 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 713600000833 probable active site [active] 713600000834 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 713600000835 putative inner membrane peptidase; Provisional; Region: PRK11778 713600000836 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 713600000837 tandem repeat interface [polypeptide binding]; other site 713600000838 oligomer interface [polypeptide binding]; other site 713600000839 active site residues [active] 713600000840 potential frameshift: common BLAST hit: gi|219682206|ref|YP_002468590.1| DNA topoisomerase I 713600000841 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713600000842 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 713600000843 active site 713600000844 dimerization interface [polypeptide binding]; other site 713600000845 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 713600000846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713600000847 FeS/SAM binding site; other site 713600000848 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 713600000849 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 713600000850 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 713600000851 potential frameshift: common BLAST hit: gi|219681653|ref|YP_002468039.1| histidyl-tRNA synthetase 713600000852 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 713600000853 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 713600000854 dimer interface [polypeptide binding]; other site 713600000855 active site 713600000856 glycine-pyridoxal phosphate binding site [chemical binding]; other site 713600000857 folate binding site [chemical binding]; other site 713600000858 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 713600000859 AAA domain; Region: AAA_26; pfam13500 713600000860 biotin synthase; Provisional; Region: PRK15108 713600000861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713600000862 FeS/SAM binding site; other site 713600000863 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 713600000864 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 713600000865 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713600000866 inhibitor-cofactor binding pocket; inhibition site 713600000867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713600000868 catalytic residue [active] 713600000869 6-phosphogluconolactonase; Provisional; Region: PRK11028 713600000870 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 713600000871 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713600000872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713600000873 ATP binding site [chemical binding]; other site 713600000874 putative Mg++ binding site [ion binding]; other site 713600000875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713600000876 nucleotide binding region [chemical binding]; other site 713600000877 ATP-binding site [chemical binding]; other site 713600000878 TRCF domain; Region: TRCF; pfam03461 713600000879 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 713600000880 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 713600000881 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713600000882 Walker A/P-loop; other site 713600000883 ATP binding site [chemical binding]; other site 713600000884 Q-loop/lid; other site 713600000885 ABC transporter signature motif; other site 713600000886 Walker B; other site 713600000887 D-loop; other site 713600000888 H-loop/switch region; other site 713600000889 potential frameshift: common BLAST hit: gi|85059056|ref|YP_454758.1| outer membrane-specific lipoprotein transporter subunit LolE 713600000890 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 713600000891 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 713600000892 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 713600000893 flavodoxin FldA; Validated; Region: PRK09267 713600000894 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 713600000895 DNA photolyase; Region: DNA_photolyase; pfam00875 713600000896 Uncharacterized conserved protein [Function unknown]; Region: COG0327 713600000897 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 713600000898 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 713600000899 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 713600000900 TPP-binding site [chemical binding]; other site 713600000901 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 713600000902 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347 713600000903 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713600000904 E3 interaction surface; other site 713600000905 lipoyl attachment site [posttranslational modification]; other site 713600000906 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713600000907 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713600000908 catalytic core [active] 713600000909 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713600000910 potential frameshift: common BLAST hit: gi|219682224|ref|YP_002468608.1| 6-phosphofructokinase 713600000911 potential frameshift: common BLAST hit: gi|219681670|ref|YP_002468056.1| glycerol uptake facilitator protein 713600000912 triosephosphate isomerase; Provisional; Region: PRK14567 713600000913 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 713600000914 substrate binding site [chemical binding]; other site 713600000915 dimer interface [polypeptide binding]; other site 713600000916 catalytic triad [active] 713600000917 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713600000918 IHF dimer interface [polypeptide binding]; other site 713600000919 IHF - DNA interface [nucleotide binding]; other site 713600000920 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 713600000921 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 713600000922 RNA binding site [nucleotide binding]; other site 713600000923 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 713600000924 RNA binding site [nucleotide binding]; other site 713600000925 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 713600000926 RNA binding site [nucleotide binding]; other site 713600000927 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 713600000928 RNA binding site [nucleotide binding]; other site 713600000929 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 713600000930 RNA binding site [nucleotide binding]; other site 713600000931 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 713600000932 RNA binding site [nucleotide binding]; other site 713600000933 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 713600000934 CMP-binding site; other site 713600000935 The sites determining sugar specificity; other site 713600000936 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713600000937 active site 713600000938 potential frameshift: common BLAST hit: gi|219682229|ref|YP_002468613.1| 3-phosphoshikimate 1-carboxyvinyltransferase 713600000939 potential frameshift: common BLAST hit: gi|219682230|ref|YP_002468614.1| phosphoserine aminotransferase 713600000940 potential frameshift: common BLAST hit: gi|219682231|ref|YP_002468615.1| seryl-tRNA synthetase 713600000941 potential frameshift: common BLAST hit: gi|219682232|ref|YP_002468616.1| thioredoxin reductase 713600000942 potential frameshift: common BLAST hit: gi|15616923|ref|NP_240136.1| thioredoxin reductase 713600000943 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 713600000944 rRNA binding site [nucleotide binding]; other site 713600000945 predicted 30S ribosome binding site; other site 713600000946 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 713600000947 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 713600000948 dimer interface [polypeptide binding]; other site 713600000949 anticodon binding site; other site 713600000950 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 713600000951 homodimer interface [polypeptide binding]; other site 713600000952 motif 1; other site 713600000953 active site 713600000954 motif 2; other site 713600000955 GAD domain; Region: GAD; pfam02938 713600000956 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713600000957 active site 713600000958 motif 3; other site 713600000959 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 713600000960 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713600000961 ABC-ATPase subunit interface; other site 713600000962 dimer interface [polypeptide binding]; other site 713600000963 putative PBP binding regions; other site 713600000964 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 713600000965 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 713600000966 pyruvate kinase; Provisional; Region: PRK05826 713600000967 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 713600000968 domain interfaces; other site 713600000969 active site 713600000970 potential frameshift: common BLAST hit: gi|219682238|ref|YP_002468622.1| glucose-6-phosphate 1-dehydrogenase 713600000971 heat shock protein HtpX; Provisional; Region: PRK05457 713600000972 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713600000973 DNA-binding site [nucleotide binding]; DNA binding site 713600000974 RNA-binding motif; other site 713600000975 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 713600000976 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 713600000977 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 713600000978 Transporter associated domain; Region: CorC_HlyC; smart01091 713600000979 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 713600000980 Glycoprotease family; Region: Peptidase_M22; pfam00814 713600000981 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 713600000982 cell division inhibitor MinD; Provisional; Region: PRK10818 713600000983 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 713600000984 Switch I; other site 713600000985 Switch II; other site 713600000986 potential frameshift: common BLAST hit: gi|219682245|ref|YP_002468629.1| cell division inhibitor MinC 713600000987 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 713600000988 potential frameshift: common BLAST hit: gi|219682246|ref|YP_002468630.1| 16S rRNA m(2)G 1207 methyltransferase 713600000989 outer membrane protein A; Reviewed; Region: PRK10808 713600000990 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 713600000991 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 713600000992 ligand binding site [chemical binding]; other site 713600000993 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 713600000994 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 713600000995 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 713600000996 active site 713600000997 substrate binding pocket [chemical binding]; other site 713600000998 dimer interface [polypeptide binding]; other site 713600000999 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 713600001000 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 713600001001 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 713600001002 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 713600001003 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 713600001004 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 713600001005 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 713600001006 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 713600001007 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 713600001008 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 713600001009 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 713600001010 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 713600001011 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 713600001012 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 713600001013 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 713600001014 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 713600001015 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 713600001016 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 713600001017 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 713600001018 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 713600001019 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 713600001020 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 713600001021 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 713600001022 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 713600001023 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 713600001024 potential frameshift: common BLAST hit: gi|15616952|ref|NP_240165.1| flagellar hook-associated protein 1 713600001025 potential frameshift: common BLAST hit: gi|15616953|ref|NP_240166.1| ribonuclease E 713600001026 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 713600001027 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713600001028 RNA binding surface [nucleotide binding]; other site 713600001029 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 713600001030 active site 713600001031 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 713600001032 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 713600001033 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 713600001034 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713600001035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713600001036 NAD(P) binding site [chemical binding]; other site 713600001037 active site 713600001038 thymidylate kinase; Validated; Region: tmk; PRK00698 713600001039 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 713600001040 TMP-binding site; other site 713600001041 ATP-binding site [chemical binding]; other site 713600001042 DNA polymerase III subunit delta'; Validated; Region: PRK07993 713600001043 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 713600001044 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 713600001045 active site 713600001046 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 713600001047 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 713600001048 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 713600001049 active site turn [active] 713600001050 phosphorylation site [posttranslational modification] 713600001051 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 713600001052 nucleotide binding site/active site [active] 713600001053 HIT family signature motif; other site 713600001054 catalytic residue [active] 713600001055 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 713600001056 potential frameshift: common BLAST hit: gi|15616964|ref|NP_240177.1| OmpF-like porin 713600001057 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 713600001058 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 713600001059 putative dimer interface [polypeptide binding]; other site 713600001060 putative anticodon binding site; other site 713600001061 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 713600001062 homodimer interface [polypeptide binding]; other site 713600001063 motif 1; other site 713600001064 motif 2; other site 713600001065 active site 713600001066 motif 3; other site 713600001067 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 713600001068 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 713600001069 active site 713600001070 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713600001071 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 713600001072 active site 713600001073 catalytic residues [active] 713600001074 quinone interaction residues [chemical binding]; other site 713600001075 substrate binding site [chemical binding]; other site 713600001076 potential frameshift: common BLAST hit: gi|219681721|ref|YP_002468107.1| 23S rRNA m2G2445 methyltransferase (YcbY) 713600001077 potential frameshift: common BLAST hit: gi|219682276|ref|YP_002468660.1| 23S rRNA m2G2445 methyltransferase (YcbY) 713600001078 potential frameshift: common BLAST hit: gi|219682276|ref|YP_002468660.1| 23S rRNA m2G2445 methyltransferase (YcbY) 713600001079 potential frameshift: common BLAST hit: gi|15616969|ref|NP_240182.1| ABC transporter ATP-binding protein Uup 713600001080 potential frameshift: common BLAST hit: gi|15616969|ref|NP_240182.1| ABC transporter ATP-binding protein Uup 713600001081 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 713600001082 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 713600001083 active site residue [active] 713600001084 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 713600001085 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713600001086 active site 713600001087 HIGH motif; other site 713600001088 nucleotide binding site [chemical binding]; other site 713600001089 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 713600001090 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 713600001091 active site 713600001092 KMSKS motif; other site 713600001093 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 713600001094 tRNA binding surface [nucleotide binding]; other site 713600001095 anticodon binding site; other site 713600001096 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 713600001097 multifunctional aminopeptidase A; Provisional; Region: PRK00913 713600001098 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 713600001099 interface (dimer of trimers) [polypeptide binding]; other site 713600001100 Substrate-binding/catalytic site; other site 713600001101 Zn-binding sites [ion binding]; other site 713600001102 potential frameshift: common BLAST hit: gi|15616973|ref|NP_240186.1| ornithine carbamoyltransferase subunit I 713600001103 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 713600001104 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 713600001105 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 713600001106 Aspartate carbamoyltransferase, regulatory subunit [Nucleotide transport and metabolism]; Region: PyrI; COG1781 713600001107 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 713600001108 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 713600001109 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 713600001110 homotrimer interaction site [polypeptide binding]; other site 713600001111 putative active site [active] 713600001112 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 713600001113 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 713600001114 ATP binding site [chemical binding]; other site 713600001115 Mg++ binding site [ion binding]; other site 713600001116 motif III; other site 713600001117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713600001118 nucleotide binding region [chemical binding]; other site 713600001119 ATP-binding site [chemical binding]; other site 713600001120 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 713600001121 putative RNA binding site [nucleotide binding]; other site 713600001122 potential frameshift: common BLAST hit: gi|219682286|ref|YP_002468670.1| polyribonucleotide nucleotidyltransferase 713600001123 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 713600001124 16S/18S rRNA binding site [nucleotide binding]; other site 713600001125 S13e-L30e interaction site [polypeptide binding]; other site 713600001126 25S rRNA binding site [nucleotide binding]; other site 713600001127 potential frameshift: common BLAST hit: gi|219682288|ref|YP_002468672.1| tRNA pseudouridine 55 synthase 713600001128 Ribosome-binding factor A; Region: RBFA; pfam02033 713600001129 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 713600001130 translation initiation factor IF-2; Validated; Region: infB; PRK05306 713600001131 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 713600001132 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 713600001133 G1 box; other site 713600001134 putative GEF interaction site [polypeptide binding]; other site 713600001135 GTP/Mg2+ binding site [chemical binding]; other site 713600001136 Switch I region; other site 713600001137 G2 box; other site 713600001138 G3 box; other site 713600001139 Switch II region; other site 713600001140 G4 box; other site 713600001141 G5 box; other site 713600001142 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 713600001143 Translation-initiation factor 2; Region: IF-2; pfam11987 713600001144 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 713600001145 potential frameshift: common BLAST hit: gi|219681736|ref|YP_002468122.1| transcription elongation factor NusA 713600001146 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 713600001147 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 713600001148 active site 713600001149 substrate binding site [chemical binding]; other site 713600001150 metal binding site [ion binding]; metal-binding site 713600001151 potential frameshift: common BLAST hit: gi|28952053|ref|NP_240199.2| cell division protein FtsH 713600001152 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 713600001153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713600001154 S-adenosylmethionine binding site [chemical binding]; other site 713600001155 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 713600001156 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 713600001157 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 713600001158 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 713600001159 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 713600001160 hinge; other site 713600001161 active site 713600001162 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 713600001163 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 713600001164 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 713600001165 GTPase CgtA; Reviewed; Region: obgE; PRK12299 713600001166 GTP1/OBG; Region: GTP1_OBG; pfam01018 713600001167 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713600001168 G1 box; other site 713600001169 GTP/Mg2+ binding site [chemical binding]; other site 713600001170 G2 box; other site 713600001171 Switch I region; other site 713600001172 G3 box; other site 713600001173 Switch II region; other site 713600001174 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 713600001175 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 713600001176 23S rRNA interface [nucleotide binding]; other site 713600001177 L3 interface [polypeptide binding]; other site 713600001178 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 713600001179 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 713600001180 Prephenate dehydratase; Region: PDT; pfam00800 713600001181 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 713600001182 putative L-Phe binding site [chemical binding]; other site 713600001183 potential frameshift: common BLAST hit: gi|219682304|ref|YP_002468688.1| signal recognition particle protein 713600001184 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 713600001185 PRC-barrel domain; Region: PRC; pfam05239 713600001186 potential frameshift: common BLAST hit: gi|219682307|ref|YP_002468691.1| tRNA (guanine-N1)-methyltransferase 713600001187 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 713600001188 protease TldD; Provisional; Region: tldD; PRK10735 713600001189 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 713600001190 Dehydroquinase class II; Region: DHquinase_II; pfam01220 713600001191 active site 713600001192 trimer interface [polypeptide binding]; other site 713600001193 dimer interface [polypeptide binding]; other site 713600001194 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 713600001195 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 713600001196 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 713600001197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713600001198 RNA binding surface [nucleotide binding]; other site 713600001199 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 713600001200 active site 713600001201 Outer membrane lipoprotein; Region: YfiO; pfam13525 713600001202 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 713600001203 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 713600001204 motif 1; other site 713600001205 active site 713600001206 motif 2; other site 713600001207 motif 3; other site 713600001208 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 713600001209 carbon storage regulator; Provisional; Region: PRK01712 713600001210 potential frameshift: common BLAST hit: gi|219682316|ref|YP_002468700.1| glutamate-cysteine ligase 713600001211 potential frameshift: common BLAST hit: gi|219682317|ref|YP_002468701.1| S-adenosylmethionine synthetase 713600001212 Endonuclease I; Region: Endonuclease_1; cl01003 713600001213 RNA methyltransferase, RsmE family; Region: TIGR00046 713600001214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 713600001215 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 713600001216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713600001217 active site 713600001218 dimer interface [polypeptide binding]; other site 713600001219 potential protein location (hypothetical protein CWU_02670 [Buchnera aphidicola str. JF98 (Acyrthosiphon pisum)]) that overlaps RNA (tRNA-L) 713600001220 potential frameshift: common BLAST hit: gi|219682321|ref|YP_002468705.1| glutaminyl-tRNA synthetase 713600001221 CTP synthetase; Validated; Region: pyrG; PRK05380 713600001222 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 713600001223 Catalytic site [active] 713600001224 active site 713600001225 UTP binding site [chemical binding]; other site 713600001226 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 713600001227 active site 713600001228 putative oxyanion hole; other site 713600001229 catalytic triad [active] 713600001230 enolase; Provisional; Region: eno; PRK00077 713600001231 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 713600001232 dimer interface [polypeptide binding]; other site 713600001233 metal binding site [ion binding]; metal-binding site 713600001234 substrate binding pocket [chemical binding]; other site 713600001235 potential frameshift: common BLAST hit: gi|219682324|ref|YP_002468708.1| lipoprotein NlpD precursor 713600001236 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 713600001237 homotrimer interaction site [polypeptide binding]; other site 713600001238 zinc binding site [ion binding]; other site 713600001239 CDP-binding sites; other site 713600001240 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 713600001241 substrate binding site; other site 713600001242 dimer interface; other site 713600001243 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 713600001244 ligand-binding site [chemical binding]; other site 713600001245 potential frameshift: common BLAST hit: gi|15617022|ref|NP_240235.1| sulfate adenylate transferase subunit 1 713600001246 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 713600001247 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 713600001248 Active Sites [active] 713600001249 siroheme synthase; Provisional; Region: cysG; PRK10637 713600001250 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 713600001251 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 713600001252 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 713600001253 active site 713600001254 SAM binding site [chemical binding]; other site 713600001255 homodimer interface [polypeptide binding]; other site 713600001256 potential frameshift: common BLAST hit: gi|219682332|ref|YP_002468716.1| phosphoadenosine phosphosulfate reductase 713600001257 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 713600001258 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 713600001259 Active Sites [active] 713600001260 sulfite reductase (NADPH) hemoprotein, beta-component; Region: CysI; TIGR02041 713600001261 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713600001262 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713600001263 potential frameshift: common BLAST hit: gi|219681779|ref|YP_002468165.1| sulfite reductase (NADPH) flavoprotein alpha-component 713600001264 potential frameshift: common BLAST hit: gi|219681780|ref|YP_002468166.1| DNA mismatch repair protein 713600001265 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 713600001266 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 713600001267 catalytic residues [active] 713600001268 hinge region; other site 713600001269 alpha helical domain; other site 713600001270 5'-3' exonuclease; Provisional; Region: PRK14976 713600001271 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 713600001272 active site 713600001273 metal binding site 1 [ion binding]; metal-binding site 713600001274 putative 5' ssDNA interaction site; other site 713600001275 metal binding site 3; metal-binding site 713600001276 metal binding site 2 [ion binding]; metal-binding site 713600001277 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 713600001278 putative DNA binding site [nucleotide binding]; other site 713600001279 putative metal binding site [ion binding]; other site 713600001280 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 713600001281 G1 box; other site 713600001282 GTP/Mg2+ binding site [chemical binding]; other site 713600001283 Switch I region; other site 713600001284 G2 box; other site 713600001285 G3 box; other site 713600001286 Switch II region; other site 713600001287 G4 box; other site 713600001288 G5 box; other site 713600001289 potential frameshift: common BLAST hit: gi|219682339|ref|YP_002468723.1| GTP-binding protein BipA 713600001290 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 713600001291 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 713600001292 catalytic site [active] 713600001293 G-X2-G-X-G-K; other site 713600001294 putative global regulator; Reviewed; Region: PRK09559 713600001295 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 713600001296 peptide chain release factor 2; Validated; Region: prfB; PRK00578 713600001297 This domain is found in peptide chain release factors; Region: PCRF; smart00937 713600001298 RF-1 domain; Region: RF-1; pfam00472 713600001299 potential frameshift: common BLAST hit: gi|219682343|ref|YP_002468727.1| lysyl-tRNA synthetase 713600001300 potential frameshift: common BLAST hit: gi|219682344|ref|YP_002468728.1| diaminopimelate decarboxylase 713600001301 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 713600001302 thymidylate synthase; Reviewed; Region: thyA; PRK01827 713600001303 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 713600001304 dimerization interface [polypeptide binding]; other site 713600001305 active site 713600001306 potential frameshift: common BLAST hit: gi|219681792|ref|YP_002468178.1| isopentenyl-adenosine A37 tRNA methylthiolase MiaB (YleA) 713600001307 potential frameshift: common BLAST hit: gi|219682347|ref|YP_002468731.1| isopentenyl-adenosine A37 tRNA methylthiolase MiaB (YleA) 713600001308 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 713600001309 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 713600001310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 713600001311 Transporter associated domain; Region: CorC_HlyC; smart01091 713600001312 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 713600001313 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 713600001314 HIGH motif; other site 713600001315 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 713600001316 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713600001317 active site 713600001318 KMSKS motif; other site 713600001319 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 713600001320 tRNA binding surface [nucleotide binding]; other site 713600001321 potential frameshift: common BLAST hit: gi|219681796|ref|YP_002468182.1| DNA polymerase III delta subunit 713600001322 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 713600001323 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 713600001324 active site 713600001325 (T/H)XGH motif; other site 713600001326 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 713600001327 CPxP motif; other site 713600001328 potential frameshift: common BLAST hit: gi|219681799|ref|YP_002468185.1| aspartate-semialdehyde dehydrogenase 713600001329 MarC family integral membrane protein; Region: MarC; cl00919 713600001330 potential frameshift: common BLAST hit: gi|219682356|ref|YP_002468740.1| phosphoglycerate kinase 713600001331 potential frameshift: common BLAST hit: gi|219682357|ref|YP_002468741.1| fructose-bisphosphate aldolase 713600001332 mechanosensitive channel MscS; Provisional; Region: PRK10334 713600001333 Conserved TM helix; Region: TM_helix; pfam05552 713600001334 Mechanosensitive ion channel; Region: MS_channel; pfam00924 713600001335 potential frameshift: common BLAST hit: gi|219681804|ref|YP_002468190.1| exodeoxyribonuclease V 125 kDa polypeptide 713600001336 potential frameshift: common BLAST hit: gi|219682359|ref|YP_002468743.1| exodeoxyribonuclease V 125 kDa polypeptide 713600001337 potential frameshift: common BLAST hit: gi|219681805|ref|YP_002468191.1| exodeoxyribonuclease V 135 kDa polypeptide 713600001338 potential frameshift: common BLAST hit: gi|15617053|ref|NP_240266.1| exodeoxyribonuclease V 135 kDa polypeptide 713600001339 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 713600001340 AAA domain; Region: AAA_30; pfam13604 713600001341 Family description; Region: UvrD_C_2; pfam13538 713600001342 N-acetylglutamate synthase; Validated; Region: PRK05279 713600001343 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 713600001344 putative feedback inhibition sensing region; other site 713600001345 putative nucleotide binding site [chemical binding]; other site 713600001346 putative substrate binding site [chemical binding]; other site 713600001347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713600001348 Coenzyme A binding pocket [chemical binding]; other site 713600001349 potential frameshift: common BLAST hit: gi|219682363|ref|YP_002468747.1| membrane-bound lytic murein transglycosylase A precursor 713600001350 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 713600001351 homopentamer interface [polypeptide binding]; other site 713600001352 active site 713600001353 thiamine-monophosphate kinase; Region: thiL; TIGR01379 713600001354 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 713600001355 ATP binding site [chemical binding]; other site 713600001356 dimerization interface [polypeptide binding]; other site 713600001357 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 713600001358 catalytic motif [active] 713600001359 Zn binding site [ion binding]; other site 713600001360 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 713600001361 RibD C-terminal domain; Region: RibD_C; cl17279 713600001362 potential frameshift: common BLAST hit: gi|219682368|ref|YP_002468752.1| transcription antitermination protein NusB 713600001363 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 713600001364 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 713600001365 TPP-binding site; other site 713600001366 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713600001367 PYR/PP interface [polypeptide binding]; other site 713600001368 dimer interface [polypeptide binding]; other site 713600001369 TPP binding site [chemical binding]; other site 713600001370 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713600001371 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 713600001372 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713600001373 substrate binding pocket [chemical binding]; other site 713600001374 chain length determination region; other site 713600001375 substrate-Mg2+ binding site; other site 713600001376 catalytic residues [active] 713600001377 aspartate-rich region 1; other site 713600001378 active site lid residues [active] 713600001379 aspartate-rich region 2; other site 713600001380 potential frameshift: common BLAST hit: gi|219682371|ref|YP_002468755.1| putative molybdenum cofactor-binding oxidoreductase (YagR) 713600001381 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 713600001382 DsrC like protein; Region: DsrC; pfam04358 713600001383 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 713600001384 UbiA prenyltransferase family; Region: UbiA; pfam01040 713600001385 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 713600001386 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 713600001387 Subunit I/III interface [polypeptide binding]; other site 713600001388 Subunit III/IV interface [polypeptide binding]; other site 713600001389 potential frameshift: common BLAST hit: gi|15617069|ref|NP_240282.1| cytochrome O ubiquinol oxidase subunit I 713600001390 potential frameshift: common BLAST hit: gi|219682376|ref|YP_002468760.1| cytochrome O ubiquinol oxidase subunit I 713600001391 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 713600001392 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 713600001393 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 713600001394 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 713600001395 potential frameshift: common BLAST hit: gi|219681824|ref|YP_002468210.1| trigger factor 713600001396 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 713600001397 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 713600001398 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 713600001399 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 713600001400 oligomer interface [polypeptide binding]; other site 713600001401 active site residues [active] 713600001402 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 713600001403 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 713600001404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713600001405 Walker A motif; other site 713600001406 ATP binding site [chemical binding]; other site 713600001407 Walker B motif; other site 713600001408 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 713600001409 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 713600001410 Found in ATP-dependent protease La (LON); Region: LON; smart00464 713600001411 Found in ATP-dependent protease La (LON); Region: LON; smart00464 713600001412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713600001413 Walker A motif; other site 713600001414 ATP binding site [chemical binding]; other site 713600001415 Walker B motif; other site 713600001416 arginine finger; other site 713600001417 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 713600001418 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 713600001419 SurA N-terminal domain; Region: SurA_N_3; cl07813 713600001420 periplasmic folding chaperone; Provisional; Region: PRK10788 713600001421 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 713600001422 potential frameshift: common BLAST hit: gi|219682384|ref|YP_002468768.1| multidrug resistance-like ATP-binding protein Mdl 713600001423 potential frameshift: common BLAST hit: gi|219682385|ref|YP_002468769.1| multidrug resistance-like ATP-binding protein MdlB 713600001424 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 713600001425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713600001426 Walker A motif; other site 713600001427 ATP binding site [chemical binding]; other site 713600001428 Walker B motif; other site 713600001429 arginine finger; other site 713600001430 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 713600001431 hypothetical protein; Validated; Region: PRK00153 713600001432 potential frameshift: common BLAST hit: gi|219682388|ref|YP_002468772.1| heat shock protein 90 713600001433 adenylate kinase; Reviewed; Region: adk; PRK00279 713600001434 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 713600001435 AMP-binding site [chemical binding]; other site 713600001436 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 713600001437 potential frameshift: common BLAST hit: gi|219682390|ref|YP_002468774.1| methenyltetrahydrofolate cyclohydrolase 713600001438 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 713600001439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713600001440 active site 713600001441 HIGH motif; other site 713600001442 nucleotide binding site [chemical binding]; other site 713600001443 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 713600001444 KMSKS motif; other site 713600001445 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 713600001446 tRNA binding surface [nucleotide binding]; other site 713600001447 anticodon binding site; other site 713600001448 hypothetical protein; Provisional; Region: PRK04998 713600001449 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713600001450 DNA-binding site [nucleotide binding]; DNA binding site 713600001451 RNA-binding motif; other site 713600001452 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 713600001453 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 713600001454 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 713600001455 shikimate binding site; other site 713600001456 NAD(P) binding site [chemical binding]; other site 713600001457 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 713600001458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Smg; COG2922 713600001459 potential frameshift: common BLAST hit: gi|219682397|ref|YP_002468781.1| polypeptide deformylase 713600001460 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 713600001461 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 713600001462 putative active site [active] 713600001463 substrate binding site [chemical binding]; other site 713600001464 putative cosubstrate binding site; other site 713600001465 catalytic site [active] 713600001466 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 713600001467 substrate binding site [chemical binding]; other site 713600001468 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 713600001469 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 713600001470 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 713600001471 alphaNTD homodimer interface [polypeptide binding]; other site 713600001472 alphaNTD - beta interaction site [polypeptide binding]; other site 713600001473 alphaNTD - beta' interaction site [polypeptide binding]; other site 713600001474 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 713600001475 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 713600001476 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 713600001477 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713600001478 RNA binding surface [nucleotide binding]; other site 713600001479 30S ribosomal protein S11; Validated; Region: PRK05309 713600001480 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 713600001481 30S ribosomal protein S13; Region: bact_S13; TIGR03631 713600001482 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 713600001483 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 713600001484 SecY translocase; Region: SecY; pfam00344 713600001485 potential frameshift: common BLAST hit: gi|219682406|ref|YP_002468790.1| 50S ribosomal protein L15 713600001486 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 713600001487 23S rRNA binding site [nucleotide binding]; other site 713600001488 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 713600001489 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 713600001490 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 713600001491 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 713600001492 5S rRNA interface [nucleotide binding]; other site 713600001493 23S rRNA interface [nucleotide binding]; other site 713600001494 L5 interface [polypeptide binding]; other site 713600001495 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 713600001496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 713600001497 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 713600001498 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 713600001499 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 713600001500 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 713600001501 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 713600001502 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 713600001503 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 713600001504 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 713600001505 RNA binding site [nucleotide binding]; other site 713600001506 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 713600001507 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 713600001508 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 713600001509 23S rRNA interface [nucleotide binding]; other site 713600001510 putative translocon interaction site; other site 713600001511 signal recognition particle (SRP54) interaction site; other site 713600001512 L23 interface [polypeptide binding]; other site 713600001513 trigger factor interaction site; other site 713600001514 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 713600001515 23S rRNA interface [nucleotide binding]; other site 713600001516 5S rRNA interface [nucleotide binding]; other site 713600001517 putative antibiotic binding site [chemical binding]; other site 713600001518 L25 interface [polypeptide binding]; other site 713600001519 L27 interface [polypeptide binding]; other site 713600001520 potential frameshift: common BLAST hit: gi|219682419|ref|YP_002468803.1| 30S ribosomal protein S3 713600001521 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 713600001522 protein-rRNA interface [nucleotide binding]; other site 713600001523 putative translocon binding site; other site 713600001524 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 713600001525 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 713600001526 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 713600001527 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 713600001528 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 713600001529 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 713600001530 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 713600001531 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 713600001532 elongation factor Tu; Reviewed; Region: PRK00049 713600001533 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 713600001534 G1 box; other site 713600001535 GEF interaction site [polypeptide binding]; other site 713600001536 GTP/Mg2+ binding site [chemical binding]; other site 713600001537 Switch I region; other site 713600001538 G2 box; other site 713600001539 G3 box; other site 713600001540 Switch II region; other site 713600001541 G4 box; other site 713600001542 G5 box; other site 713600001543 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 713600001544 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 713600001545 Antibiotic Binding Site [chemical binding]; other site 713600001546 potential frameshift: common BLAST hit: gi|219682428|ref|YP_002468812.1| elongation factor G 713600001547 potential frameshift: common BLAST hit: gi|219682428|ref|YP_002468812.1| elongation factor G 713600001548 30S ribosomal protein S7; Validated; Region: PRK05302 713600001549 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 713600001550 S17 interaction site [polypeptide binding]; other site 713600001551 S8 interaction site; other site 713600001552 16S rRNA interaction site [nucleotide binding]; other site 713600001553 streptomycin interaction site [chemical binding]; other site 713600001554 23S rRNA interaction site [nucleotide binding]; other site 713600001555 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 713600001556 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 713600001557 sulfur relay protein TusC; Validated; Region: PRK00211 713600001558 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 713600001559 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 713600001560 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 713600001561 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 713600001562 potential frameshift: common BLAST hit: gi|219682435|ref|YP_002468819.1| bifunctional 713600001563 putative transporter; Provisional; Region: PRK03699 713600001564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713600001565 putative substrate translocation pore; other site 713600001566 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 713600001567 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 713600001568 active site 713600001569 HIGH motif; other site 713600001570 dimer interface [polypeptide binding]; other site 713600001571 KMSKS motif; other site 713600001572 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 713600001573 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 713600001574 substrate binding site [chemical binding]; other site 713600001575 hexamer interface [polypeptide binding]; other site 713600001576 metal binding site [ion binding]; metal-binding site 713600001577 potential frameshift: common BLAST hit: gi|219682439|ref|YP_002468823.1| 3-dehydroquinate synthase 713600001578 shikimate kinase; Reviewed; Region: aroK; PRK00131 713600001579 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 713600001580 ADP binding site [chemical binding]; other site 713600001581 magnesium binding site [ion binding]; other site 713600001582 putative shikimate binding site; other site 713600001583 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 713600001584 potential frameshift: common BLAST hit: gi|15617135|ref|NP_240348.1| phosphopentomutase 713600001585 potential frameshift: common BLAST hit: gi|219681888|ref|YP_002468274.1| peptide chain release factor 3 713600001586 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 713600001587 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 713600001588 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 713600001589 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713600001590 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713600001591 dimer interface [polypeptide binding]; other site 713600001592 ssDNA binding site [nucleotide binding]; other site 713600001593 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713600001594 replicative DNA helicase; Provisional; Region: PRK08006 713600001595 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 713600001596 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 713600001597 Walker A motif; other site 713600001598 ATP binding site [chemical binding]; other site 713600001599 Walker B motif; other site 713600001600 DNA binding loops [nucleotide binding] 713600001601 glutathione synthetase; Provisional; Region: PRK05246 713600001602 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 713600001603 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 713600001604 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 713600001605 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 713600001606 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713600001607 catalytic residue [active] 713600001608 HemN family oxidoreductase; Provisional; Region: PRK05660 713600001609 HemN C-terminal domain; Region: HemN_C; pfam06969 713600001610 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 713600001611 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 713600001612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 713600001613 minor groove reading motif; other site 713600001614 helix-hairpin-helix signature motif; other site 713600001615 substrate binding pocket [chemical binding]; other site 713600001616 active site 713600001617 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 713600001618 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 713600001619 DNA binding and oxoG recognition site [nucleotide binding] 713600001620 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 713600001621 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 713600001622 potential frameshift: common BLAST hit: gi|15617148|ref|NP_240361.1| exonuclease I 713600001623 hypothetical protein; Provisional; Region: PRK05423 713600001624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713600001625 active site 713600001626 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 713600001627 trimer interface [polypeptide binding]; other site 713600001628 active site 713600001629 potential frameshift: common BLAST hit: gi|219682458|ref|YP_002468842.1| CysQ protein 713600001630 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 713600001631 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 713600001632 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 713600001633 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 713600001634 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 713600001635 potential frameshift: common BLAST hit: gi|219681907|ref|YP_002468293.1| VacB protein 713600001636 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 713600001637 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 713600001638 GDP-binding site [chemical binding]; other site 713600001639 ACT binding site; other site 713600001640 IMP binding site; other site 713600001641 FtsH protease regulator HflC; Provisional; Region: PRK11029 713600001642 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 713600001643 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 713600001644 HflK protein; Region: hflK; TIGR01933 713600001645 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 713600001646 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 713600001647 potential frameshift: common BLAST hit: gi|219681912|ref|YP_002468298.1| DNA mismatch repair protein MutL 713600001648 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 713600001649 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 713600001650 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 713600001651 potential frameshift: common BLAST hit: gi|219681914|ref|YP_002468300.1| PTS system mannitol-specific IIABC component 713600001652 potential frameshift: common BLAST hit: gi|219682469|ref|YP_002468853.1| PTS system mannitol-specific IIABC component 713600001653 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 713600001654 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 713600001655 active site 713600001656 dimer interface [polypeptide binding]; other site 713600001657 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 713600001658 dimer interface [polypeptide binding]; other site 713600001659 active site 713600001660 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 713600001661 catalytic site [active] 713600001662 putative active site [active] 713600001663 putative substrate binding site [chemical binding]; other site 713600001664 dimer interface [polypeptide binding]; other site 713600001665 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 713600001666 active site 713600001667 metal binding site [ion binding]; metal-binding site 713600001668 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 713600001669 Sporulation related domain; Region: SPOR; cl10051 713600001670 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 713600001671 active site 713600001672 HslU subunit interaction site [polypeptide binding]; other site 713600001673 potential frameshift: common BLAST hit: gi|219682475|ref|YP_002468859.1| ATP-dependent protease ATP-binding subunit 713600001674 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 713600001675 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 713600001676 putative dimer interface [polypeptide binding]; other site 713600001677 ferredoxin-NADP reductase; Provisional; Region: PRK10926 713600001678 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 713600001679 FAD binding pocket [chemical binding]; other site 713600001680 FAD binding motif [chemical binding]; other site 713600001681 phosphate binding motif [ion binding]; other site 713600001682 beta-alpha-beta structure motif; other site 713600001683 NAD binding pocket [chemical binding]; other site 713600001684 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 713600001685 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713600001686 motif 1; other site 713600001687 dimer interface [polypeptide binding]; other site 713600001688 active site 713600001689 motif 2; other site 713600001690 motif 3; other site 713600001691 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 713600001692 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 713600001693 active site 713600001694 (T/H)XGH motif; other site 713600001695 potential frameshift: common BLAST hit: gi|219682482|ref|YP_002468866.1| predicted SAM-dependent methyltransferase (YhiQ) 713600001696 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 713600001697 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 713600001698 potential frameshift: common BLAST hit: gi|27905003|ref|NP_778129.1| putative transport protein 713600001699 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 713600001700 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 713600001701 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 713600001702 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 713600001703 putative iron binding site [ion binding]; other site 713600001704 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 713600001705 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 713600001706 domain interfaces; other site 713600001707 active site 713600001708 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 713600001709 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 713600001710 active site 713600001711 potential frameshift: common BLAST hit: gi|219682487|ref|YP_002468871.1| transcription termination factor Rho 713600001712 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 713600001713 Part of AAA domain; Region: AAA_19; pfam13245 713600001714 Family description; Region: UvrD_C_2; pfam13538 713600001715 ketol-acid reductoisomerase; Validated; Region: PRK05225 713600001716 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 713600001717 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 713600001718 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 713600001719 potential frameshift: common BLAST hit: gi|219682491|ref|YP_002468875.1| dihydroxy-acid dehydratase 713600001720 cysteine desulfurase; Provisional; Region: PRK14012 713600001721 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 713600001722 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713600001723 catalytic residue [active] 713600001724 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 713600001725 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 713600001726 trimerization site [polypeptide binding]; other site 713600001727 active site 713600001728 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 713600001729 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 713600001730 potential frameshift: common BLAST hit: gi|219682495|ref|YP_002468879.1| heat shock protein HscA 713600001731 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 713600001732 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713600001733 catalytic loop [active] 713600001734 iron binding site [ion binding]; other site 713600001735 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 713600001736 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 713600001737 G1 box; other site 713600001738 GTP/Mg2+ binding site [chemical binding]; other site 713600001739 Switch I region; other site 713600001740 G2 box; other site 713600001741 Switch II region; other site 713600001742 G3 box; other site 713600001743 G4 box; other site 713600001744 G5 box; other site 713600001745 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 713600001746 G1 box; other site 713600001747 GTP/Mg2+ binding site [chemical binding]; other site 713600001748 Switch I region; other site 713600001749 G2 box; other site 713600001750 G3 box; other site 713600001751 Switch II region; other site 713600001752 G4 box; other site 713600001753 G5 box; other site 713600001754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976