-- dump date 20120504_140217 -- class Genbank::misc_feature -- table misc_feature_note -- id note 271848000001 UNKNOWN FEATURE KEY Comment; Burkholderia thailandensis E264 is an environmental isolate and the type strain of the species. It is available from the American Type Culture Collection, Mananass, VA. 271848000002 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 271848000003 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271848000004 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 271848000005 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 271848000006 active site 271848000007 Int/Topo IB signature motif; other site 271848000008 catalytic residues [active] 271848000009 DNA binding site [nucleotide binding] 271848000010 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 271848000011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848000012 non-specific DNA binding site [nucleotide binding]; other site 271848000013 salt bridge; other site 271848000014 sequence-specific DNA binding site [nucleotide binding]; other site 271848000015 Cupin domain; Region: Cupin_2; cl09118 271848000016 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 271848000017 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 271848000018 substrate-cofactor binding pocket; other site 271848000019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848000020 catalytic residue [active] 271848000021 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 271848000022 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 271848000023 NAD(P) binding site [chemical binding]; other site 271848000024 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 271848000025 putative acetyltransferase; Provisional; Region: PRK03624 271848000026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848000027 Coenzyme A binding pocket [chemical binding]; other site 271848000028 YceI-like domain; Region: YceI; cl01001 271848000029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848000030 Helix-turn-helix domains; Region: HTH; cl00088 271848000031 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 271848000032 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848000033 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 271848000034 putative active site [active] 271848000035 Zn binding site [ion binding]; other site 271848000036 tartrate dehydrogenase; Provisional; Region: PRK08194 271848000037 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 271848000038 transcriptional activator TtdR; Provisional; Region: PRK09801 271848000039 Helix-turn-helix domains; Region: HTH; cl00088 271848000040 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 271848000041 putative effector binding pocket; other site 271848000042 putative dimerization interface [polypeptide binding]; other site 271848000043 Phospholipid methyltransferase; Region: PEMT; cl00763 271848000044 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848000045 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 271848000046 putative C-terminal domain interface [polypeptide binding]; other site 271848000047 putative GSH binding site (G-site) [chemical binding]; other site 271848000048 putative dimer interface [polypeptide binding]; other site 271848000049 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 271848000050 putative N-terminal domain interface [polypeptide binding]; other site 271848000051 putative dimer interface [polypeptide binding]; other site 271848000052 putative substrate binding pocket (H-site) [chemical binding]; other site 271848000053 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 271848000054 nucleophile elbow; other site 271848000055 Patatin phospholipase; Region: DUF3734; pfam12536 271848000056 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 271848000057 classical (c) SDRs; Region: SDR_c; cd05233 271848000058 NAD(P) binding site [chemical binding]; other site 271848000059 active site 271848000060 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 271848000061 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 271848000062 active site 271848000063 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 271848000064 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 271848000065 FAD binding pocket [chemical binding]; other site 271848000066 FAD binding motif [chemical binding]; other site 271848000067 phosphate binding motif [ion binding]; other site 271848000068 NAD binding pocket [chemical binding]; other site 271848000069 Helix-turn-helix domains; Region: HTH; cl00088 271848000070 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 271848000071 Protein of unknown function (DUF692); Region: DUF692; cl01263 271848000072 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 271848000073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848000074 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 271848000075 FeS/SAM binding site; other site 271848000076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000077 S-adenosylmethionine binding site [chemical binding]; other site 271848000078 LysE type translocator; Region: LysE; cl00565 271848000079 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 271848000080 Helix-turn-helix domains; Region: HTH; cl00088 271848000081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000082 dimerization interface [polypeptide binding]; other site 271848000083 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 271848000084 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848000085 ligand binding site [chemical binding]; other site 271848000086 flexible hinge region; other site 271848000087 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271848000088 putative switch regulator; other site 271848000089 non-specific DNA interactions [nucleotide binding]; other site 271848000090 DNA binding site [nucleotide binding] 271848000091 sequence specific DNA binding site [nucleotide binding]; other site 271848000092 putative cAMP binding site [chemical binding]; other site 271848000093 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848000094 Ligand Binding Site [chemical binding]; other site 271848000095 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848000096 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 271848000097 dimer interface [polypeptide binding]; other site 271848000098 NADP binding site [chemical binding]; other site 271848000099 catalytic residues [active] 271848000100 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 271848000101 Transcriptional activator HlyU; Region: HlyU; cl02273 271848000102 serine O-acetyltransferase; Region: cysE; TIGR01172 271848000103 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 271848000104 trimer interface [polypeptide binding]; other site 271848000105 active site 271848000106 substrate binding site [chemical binding]; other site 271848000107 CoA binding site [chemical binding]; other site 271848000108 pteridine reductase; Provisional; Region: PRK09135 271848000109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000110 NAD(P) binding site [chemical binding]; other site 271848000111 active site 271848000112 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271848000113 GTP cyclohydrolase I; Provisional; Region: PLN03044 271848000114 active site 271848000115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000116 Helix-turn-helix domains; Region: HTH; cl00088 271848000117 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 271848000118 substrate binding pocket [chemical binding]; other site 271848000119 dimerization interface [polypeptide binding]; other site 271848000120 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 271848000121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000122 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 271848000123 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 271848000124 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 271848000125 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 271848000126 tetramer interface [polypeptide binding]; other site 271848000127 active site 271848000128 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 271848000129 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848000130 benzoate transport; Region: 2A0115; TIGR00895 271848000131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000132 putative substrate translocation pore; other site 271848000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000134 LysE type translocator; Region: LysE; cl00565 271848000135 thioredoxin 2; Provisional; Region: PRK10996 271848000136 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848000137 catalytic residues [active] 271848000138 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 271848000139 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 271848000140 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 271848000141 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271848000142 Protein export membrane protein; Region: SecD_SecF; cl14618 271848000143 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848000144 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848000145 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848000146 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848000147 dimerization interface [polypeptide binding]; other site 271848000148 putative DNA binding site [nucleotide binding]; other site 271848000149 putative Zn2+ binding site [ion binding]; other site 271848000150 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848000151 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271848000152 Walker A/P-loop; other site 271848000153 ATP binding site [chemical binding]; other site 271848000154 Q-loop/lid; other site 271848000155 ABC transporter signature motif; other site 271848000156 Walker B; other site 271848000157 D-loop; other site 271848000158 H-loop/switch region; other site 271848000159 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271848000160 FtsX-like permease family; Region: FtsX; cl15850 271848000161 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848000162 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848000163 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 271848000165 CreA protein; Region: CreA; pfam05981 271848000166 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271848000167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 271848000168 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848000169 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 271848000170 Cation efflux family; Region: Cation_efflux; cl00316 271848000171 haemagglutination activity domain; Region: Haemagg_act; cl05436 271848000172 Surface antigen; Region: Bac_surface_Ag; cl03097 271848000173 Chromate transporter; Region: Chromate_transp; pfam02417 271848000174 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 271848000175 Chromate transporter; Region: Chromate_transp; pfam02417 271848000176 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 271848000177 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 271848000178 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 271848000179 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 271848000180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848000181 Walker A/P-loop; other site 271848000182 ATP binding site [chemical binding]; other site 271848000183 Q-loop/lid; other site 271848000184 ABC transporter signature motif; other site 271848000185 Walker B; other site 271848000186 D-loop; other site 271848000187 H-loop/switch region; other site 271848000188 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 271848000189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848000190 Walker A/P-loop; other site 271848000191 ATP binding site [chemical binding]; other site 271848000192 Q-loop/lid; other site 271848000193 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 271848000194 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 271848000195 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 271848000196 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 271848000197 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 271848000198 Phosphoesterase family; Region: Phosphoesterase; cl15450 271848000199 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848000200 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848000201 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848000202 DNA-binding interface [nucleotide binding]; DNA binding site 271848000203 RNA polymerase sigma factor; Reviewed; Region: PRK12527 271848000204 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848000205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848000206 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 271848000207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848000208 Coenzyme A binding pocket [chemical binding]; other site 271848000209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848000210 dimer interface [polypeptide binding]; other site 271848000211 conserved gate region; other site 271848000212 putative PBP binding loops; other site 271848000213 ABC-ATPase subunit interface; other site 271848000214 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 271848000215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848000216 dimer interface [polypeptide binding]; other site 271848000217 conserved gate region; other site 271848000218 putative PBP binding loops; other site 271848000219 ABC-ATPase subunit interface; other site 271848000220 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 271848000221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000222 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 271848000223 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848000224 H-NS histone family; Region: Histone_HNS; pfam00816 271848000225 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848000226 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848000227 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848000228 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848000229 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848000230 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848000231 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 271848000232 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 271848000233 PAAR motif; Region: PAAR_motif; cl15808 271848000234 Integrase core domain; Region: rve; cl01316 271848000235 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 271848000236 Helix-turn-helix domains; Region: HTH; cl00088 271848000237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848000238 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848000239 HTH-like domain; Region: HTH_21; pfam13276 271848000240 Integrase core domain; Region: rve; cl01316 271848000241 Integrase core domain; Region: rve_3; cl15866 271848000242 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 271848000243 PAAR motif; Region: PAAR_motif; cl15808 271848000244 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 271848000245 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848000246 catalytic residues [active] 271848000247 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848000248 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848000249 trimer interface [polypeptide binding]; other site 271848000250 eyelet of channel; other site 271848000251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000252 Helix-turn-helix domains; Region: HTH; cl00088 271848000253 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848000254 putative effector binding pocket; other site 271848000255 dimerization interface [polypeptide binding]; other site 271848000256 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 271848000257 Helix-turn-helix domains; Region: HTH; cl00088 271848000258 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 271848000259 dimerization interface [polypeptide binding]; other site 271848000260 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848000261 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 271848000262 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848000263 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848000264 Fusaric acid resistance protein family; Region: FUSC; pfam04632 271848000265 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 271848000266 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 271848000267 YadA-like C-terminal region; Region: YadA; pfam03895 271848000268 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 271848000269 YfaZ precursor; Region: YfaZ; pfam07437 271848000270 Fimbrial protein; Region: Fimbrial; cl01416 271848000271 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 271848000272 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 271848000273 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 271848000274 PapC N-terminal domain; Region: PapC_N; pfam13954 271848000275 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 271848000276 PapC C-terminal domain; Region: PapC_C; pfam13953 271848000277 Fimbrial protein; Region: Fimbrial; cl01416 271848000278 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 271848000279 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848000280 ligand binding site [chemical binding]; other site 271848000281 Protein of unknown function (DUF770); Region: DUF770; cl01402 271848000282 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 271848000283 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848000284 Protein of unknown function (DUF796); Region: DUF796; cl01226 271848000285 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 271848000286 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 271848000287 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848000288 hypothetical protein; Provisional; Region: PRK08126 271848000289 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 271848000290 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848000291 ligand binding site [chemical binding]; other site 271848000292 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 271848000293 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 271848000294 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848000295 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271848000296 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848000297 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848000298 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848000299 PAAR motif; Region: PAAR_motif; cl15808 271848000300 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848000301 RHS Repeat; Region: RHS_repeat; cl11982 271848000302 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848000303 RHS Repeat; Region: RHS_repeat; cl11982 271848000304 RHS Repeat; Region: RHS_repeat; cl11982 271848000305 RHS Repeat; Region: RHS_repeat; cl11982 271848000306 RHS protein; Region: RHS; pfam03527 271848000307 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 271848000308 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 271848000309 Fimbrial protein; Region: Fimbrial; cl01416 271848000310 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271848000311 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848000312 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 271848000313 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848000314 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848000315 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848000316 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 271848000317 ImpE protein; Region: ImpE; pfam07024 271848000318 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848000319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848000320 Walker A motif; other site 271848000321 ATP binding site [chemical binding]; other site 271848000322 Walker B motif; other site 271848000323 arginine finger; other site 271848000324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848000325 Walker A motif; other site 271848000326 ATP binding site [chemical binding]; other site 271848000327 Walker B motif; other site 271848000328 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848000329 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 271848000330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848000331 dimer interface [polypeptide binding]; other site 271848000332 phosphorylation site [posttranslational modification] 271848000333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848000334 ATP binding site [chemical binding]; other site 271848000335 Mg2+ binding site [ion binding]; other site 271848000336 G-X-G motif; other site 271848000337 Response regulator receiver domain; Region: Response_reg; pfam00072 271848000338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000339 active site 271848000340 phosphorylation site [posttranslational modification] 271848000341 intermolecular recognition site; other site 271848000342 dimerization interface [polypeptide binding]; other site 271848000343 transcriptional regulator RcsB; Provisional; Region: PRK10840 271848000344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000345 active site 271848000346 phosphorylation site [posttranslational modification] 271848000347 intermolecular recognition site; other site 271848000348 dimerization interface [polypeptide binding]; other site 271848000349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848000350 DNA binding residues [nucleotide binding] 271848000351 dimerization interface [polypeptide binding]; other site 271848000352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848000353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000354 active site 271848000355 phosphorylation site [posttranslational modification] 271848000356 intermolecular recognition site; other site 271848000357 dimerization interface [polypeptide binding]; other site 271848000358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848000359 DNA binding residues [nucleotide binding] 271848000360 dimerization interface [polypeptide binding]; other site 271848000361 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848000362 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848000363 substrate binding pocket [chemical binding]; other site 271848000364 membrane-bound complex binding site; other site 271848000365 hinge residues; other site 271848000366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848000367 dimer interface [polypeptide binding]; other site 271848000368 phosphorylation site [posttranslational modification] 271848000369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848000370 ATP binding site [chemical binding]; other site 271848000371 Mg2+ binding site [ion binding]; other site 271848000372 G-X-G motif; other site 271848000373 Response regulator receiver domain; Region: Response_reg; pfam00072 271848000374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000375 active site 271848000376 phosphorylation site [posttranslational modification] 271848000377 intermolecular recognition site; other site 271848000378 dimerization interface [polypeptide binding]; other site 271848000379 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 271848000380 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 271848000381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 271848000382 active site 271848000383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848000384 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 271848000385 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848000386 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848000387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848000388 active site 271848000389 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 271848000390 flagellin; Provisional; Region: PRK12802 271848000391 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271848000392 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 271848000393 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271848000394 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 271848000395 hypothetical protein; Validated; Region: PRK06778 271848000396 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 271848000397 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848000398 ligand binding site [chemical binding]; other site 271848000399 Response regulator receiver domain; Region: Response_reg; pfam00072 271848000400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000401 active site 271848000402 phosphorylation site [posttranslational modification] 271848000403 intermolecular recognition site; other site 271848000404 dimerization interface [polypeptide binding]; other site 271848000405 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 271848000406 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271848000407 putative binding surface; other site 271848000408 active site 271848000409 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 271848000410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848000411 ATP binding site [chemical binding]; other site 271848000412 Mg2+ binding site [ion binding]; other site 271848000413 G-X-G motif; other site 271848000414 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 271848000415 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848000416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848000417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848000418 dimer interface [polypeptide binding]; other site 271848000419 putative CheW interface [polypeptide binding]; other site 271848000420 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 271848000421 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271848000422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000423 CheD chemotactic sensory transduction; Region: CheD; cl00810 271848000424 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271848000425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000426 active site 271848000427 phosphorylation site [posttranslational modification] 271848000428 intermolecular recognition site; other site 271848000429 dimerization interface [polypeptide binding]; other site 271848000430 CheB methylesterase; Region: CheB_methylest; pfam01339 271848000431 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271848000432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000433 active site 271848000434 phosphorylation site [posttranslational modification] 271848000435 intermolecular recognition site; other site 271848000436 dimerization interface [polypeptide binding]; other site 271848000437 CheB methylesterase; Region: CheB_methylest; pfam01339 271848000438 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 271848000439 FHIPEP family; Region: FHIPEP; pfam00771 271848000440 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 271848000441 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271848000442 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 271848000443 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 271848000444 FliP family; Region: FliP; cl00593 271848000445 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271848000446 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271848000447 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 271848000448 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 271848000449 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 271848000450 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 271848000451 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 271848000452 FliG C-terminal domain; Region: FliG_C; pfam01706 271848000453 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 271848000454 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 271848000455 Flagellar assembly protein FliH; Region: FliH; pfam02108 271848000456 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 271848000457 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 271848000458 Walker A motif/ATP binding site; other site 271848000459 Walker B motif; other site 271848000460 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 271848000461 flagellar capping protein; Reviewed; Region: fliD; PRK08032 271848000462 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 271848000463 Flagellar protein FliS; Region: FliS; cl00654 271848000464 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 271848000465 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 271848000466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848000467 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271848000468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848000469 DNA binding residues [nucleotide binding] 271848000470 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 271848000471 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 271848000472 SAF-like; Region: SAF_2; pfam13144 271848000473 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 271848000474 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 271848000475 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848000476 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 271848000477 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 271848000478 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848000479 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848000480 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 271848000481 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 271848000482 FlgD Ig-like domain; Region: FlgD_ig; cl15790 271848000483 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 271848000484 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848000485 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 271848000486 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848000487 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 271848000488 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848000489 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 271848000490 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848000491 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848000492 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 271848000493 Flagellar L-ring protein; Region: FlgH; cl00905 271848000494 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 271848000495 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 271848000496 Rod binding protein; Region: Rod-binding; cl01626 271848000497 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 271848000498 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848000499 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 271848000500 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271848000501 Helix-turn-helix domains; Region: HTH; cl00088 271848000502 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848000503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000504 active site 271848000505 phosphorylation site [posttranslational modification] 271848000506 intermolecular recognition site; other site 271848000507 dimerization interface [polypeptide binding]; other site 271848000508 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848000509 DNA binding residues [nucleotide binding] 271848000510 dimerization interface [polypeptide binding]; other site 271848000511 H-NS histone family; Region: Histone_HNS; pfam00816 271848000512 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848000513 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 271848000514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000515 putative substrate translocation pore; other site 271848000516 Glycerate kinase family; Region: Gly_kinase; cl00841 271848000517 pyruvate kinase; Provisional; Region: PRK06247 271848000518 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848000519 domain interfaces; other site 271848000520 active site 271848000521 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 271848000522 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 271848000523 Helix-turn-helix domains; Region: HTH; cl00088 271848000524 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848000525 AMP-binding enzyme; Region: AMP-binding; cl15778 271848000526 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848000527 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 271848000528 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848000529 extended (e) SDRs; Region: SDR_e; cd08946 271848000530 NAD(P) binding site [chemical binding]; other site 271848000531 active site 271848000532 substrate binding site [chemical binding]; other site 271848000533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000534 active site 271848000535 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848000536 O-methyltransferase; Region: Methyltransf_2; pfam00891 271848000537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848000538 metal binding site [ion binding]; metal-binding site 271848000539 active site 271848000540 I-site; other site 271848000541 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 271848000542 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848000543 putative ligand binding site [chemical binding]; other site 271848000544 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848000545 TM-ABC transporter signature motif; other site 271848000546 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848000547 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 271848000548 Walker A/P-loop; other site 271848000549 ATP binding site [chemical binding]; other site 271848000550 Q-loop/lid; other site 271848000551 ABC transporter signature motif; other site 271848000552 Walker B; other site 271848000553 D-loop; other site 271848000554 H-loop/switch region; other site 271848000555 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 271848000556 Helix-turn-helix domains; Region: HTH; cl00088 271848000557 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 271848000558 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 271848000559 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 271848000560 Domain interface; other site 271848000561 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 271848000562 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 271848000563 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 271848000564 starch-binding site 2 [chemical binding]; other site 271848000565 starch-binding site 1 [chemical binding]; other site 271848000566 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 271848000567 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271848000568 ATP binding site [chemical binding]; other site 271848000569 Mg++ binding site [ion binding]; other site 271848000570 motif III; other site 271848000571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848000572 nucleotide binding region [chemical binding]; other site 271848000573 ATP-binding site [chemical binding]; other site 271848000574 DbpA RNA binding domain; Region: DbpA; pfam03880 271848000575 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848000576 trimer interface [polypeptide binding]; other site 271848000577 eyelet of channel; other site 271848000578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000579 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848000580 putative substrate translocation pore; other site 271848000581 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 271848000582 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 271848000583 metal binding site [ion binding]; metal-binding site 271848000584 putative dimer interface [polypeptide binding]; other site 271848000585 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 271848000586 Helix-turn-helix domains; Region: HTH; cl00088 271848000587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000588 dimerization interface [polypeptide binding]; other site 271848000589 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 271848000590 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 271848000591 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 271848000592 putative di-iron ligands [ion binding]; other site 271848000593 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848000594 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848000595 substrate binding pocket [chemical binding]; other site 271848000596 membrane-bound complex binding site; other site 271848000597 hinge residues; other site 271848000598 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 271848000599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000601 Helix-turn-helix domains; Region: HTH; cl00088 271848000602 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000603 dimerization interface [polypeptide binding]; other site 271848000604 short chain dehydrogenase; Provisional; Region: PRK07023 271848000605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000606 NAD(P) binding site [chemical binding]; other site 271848000607 active site 271848000608 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848000609 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 271848000610 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 271848000611 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 271848000612 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 271848000613 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 271848000614 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 271848000615 substrate binding pocket [chemical binding]; other site 271848000616 active site 271848000617 iron coordination sites [ion binding]; other site 271848000618 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 271848000619 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 271848000620 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 271848000621 active site 271848000622 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 271848000623 dimer interface [polypeptide binding]; other site 271848000624 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271848000625 Ligand Binding Site [chemical binding]; other site 271848000626 Molecular Tunnel; other site 271848000627 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 271848000628 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 271848000629 NADP binding site [chemical binding]; other site 271848000630 dimer interface [polypeptide binding]; other site 271848000631 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 271848000632 active site 271848000633 metal binding site [ion binding]; metal-binding site 271848000634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000635 Helix-turn-helix domains; Region: HTH; cl00088 271848000636 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848000637 putative effector binding pocket; other site 271848000638 dimerization interface [polypeptide binding]; other site 271848000639 PAAR motif; Region: PAAR_motif; cl15808 271848000640 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 271848000641 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 271848000642 tetramer interface [polypeptide binding]; other site 271848000643 TPP-binding site [chemical binding]; other site 271848000644 heterodimer interface [polypeptide binding]; other site 271848000645 phosphorylation loop region [posttranslational modification] 271848000646 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 271848000647 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 271848000648 alpha subunit interface [polypeptide binding]; other site 271848000649 TPP binding site [chemical binding]; other site 271848000650 heterodimer interface [polypeptide binding]; other site 271848000651 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848000652 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 271848000653 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848000654 E3 interaction surface; other site 271848000655 lipoyl attachment site [posttranslational modification]; other site 271848000656 e3 binding domain; Region: E3_binding; pfam02817 271848000657 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 271848000658 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271848000659 phosphate binding site [ion binding]; other site 271848000660 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848000661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000662 putative substrate translocation pore; other site 271848000663 Isochorismatase family; Region: Isochorismatase; pfam00857 271848000664 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 271848000665 catalytic triad [active] 271848000666 dimer interface [polypeptide binding]; other site 271848000667 conserved cis-peptide bond; other site 271848000668 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848000669 Helix-turn-helix domains; Region: HTH; cl00088 271848000670 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 271848000671 putative effector binding pocket; other site 271848000672 putative dimerization interface [polypeptide binding]; other site 271848000673 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848000674 Helix-turn-helix domains; Region: HTH; cl00088 271848000675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000676 dimerization interface [polypeptide binding]; other site 271848000677 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 271848000678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848000679 catalytic residue [active] 271848000680 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848000681 Helix-turn-helix domains; Region: HTH; cl00088 271848000682 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848000683 dimerization interface [polypeptide binding]; other site 271848000684 substrate binding pocket [chemical binding]; other site 271848000685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000686 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848000687 NAD(P) binding site [chemical binding]; other site 271848000688 active site 271848000689 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 271848000690 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271848000691 phosphopeptide binding site; other site 271848000692 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 271848000693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271848000694 binding surface 271848000695 TPR motif; other site 271848000696 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 271848000697 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 271848000698 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848000699 hypothetical protein; Provisional; Region: PRK07033 271848000700 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 271848000701 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848000702 ligand binding site [chemical binding]; other site 271848000703 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 271848000704 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 271848000705 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848000706 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271848000707 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 271848000708 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271848000709 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271848000710 active site 271848000711 ATP binding site [chemical binding]; other site 271848000712 substrate binding site [chemical binding]; other site 271848000713 activation loop (A-loop); other site 271848000714 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271848000715 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848000716 Protein of unknown function (DUF770); Region: DUF770; cl01402 271848000717 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 271848000718 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848000719 Protein of unknown function (DUF796); Region: DUF796; cl01226 271848000720 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848000721 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848000722 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848000723 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 271848000724 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848000725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848000726 Walker A motif; other site 271848000727 ATP binding site [chemical binding]; other site 271848000728 Walker B motif; other site 271848000729 arginine finger; other site 271848000730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848000731 Walker A motif; other site 271848000732 ATP binding site [chemical binding]; other site 271848000733 Walker B motif; other site 271848000734 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848000735 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848000736 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848000737 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848000738 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 271848000739 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 271848000740 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848000741 RHS Repeat; Region: RHS_repeat; cl11982 271848000742 RHS Repeat; Region: RHS_repeat; cl11982 271848000743 RHS Repeat; Region: RHS_repeat; cl11982 271848000744 RHS Repeat; Region: RHS_repeat; cl11982 271848000745 RHS Repeat; Region: RHS_repeat; cl11982 271848000746 RHS Repeat; Region: RHS_repeat; cl11982 271848000747 RHS Repeat; Region: RHS_repeat; cl11982 271848000748 RHS Repeat; Region: RHS_repeat; cl11982 271848000749 RHS Repeat; Region: RHS_repeat; cl11982 271848000750 RHS protein; Region: RHS; pfam03527 271848000751 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 271848000752 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 271848000753 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848000754 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848000755 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848000756 MULE transposase domain; Region: MULE; pfam10551 271848000757 haloacid dehalogenase-like hydrolase family protein; Region: PLN02770 271848000758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848000759 motif II; other site 271848000760 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 271848000761 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 271848000762 dimer interface [polypeptide binding]; other site 271848000763 ADP-ribose binding site [chemical binding]; other site 271848000764 active site 271848000765 nudix motif; other site 271848000766 metal binding site [ion binding]; metal-binding site 271848000767 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848000768 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848000769 CoenzymeA binding site [chemical binding]; other site 271848000770 subunit interaction site [polypeptide binding]; other site 271848000771 PHB binding site; other site 271848000772 acyl-CoA synthetase; Validated; Region: PRK05850 271848000773 AMP-binding enzyme; Region: AMP-binding; cl15778 271848000774 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848000775 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848000776 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848000777 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848000778 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848000779 Di-iron ligands [ion binding]; other site 271848000780 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848000781 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 271848000782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000783 S-adenosylmethionine binding site [chemical binding]; other site 271848000784 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848000785 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848000786 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848000787 Di-iron ligands [ion binding]; other site 271848000788 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848000789 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 271848000790 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848000791 conserved cys residue [active] 271848000792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848000793 Isochorismatase family; Region: Isochorismatase; pfam00857 271848000794 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 271848000795 catalytic triad [active] 271848000796 conserved cis-peptide bond; other site 271848000797 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 271848000798 AMP-binding enzyme; Region: AMP-binding; cl15778 271848000799 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 271848000800 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848000801 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 271848000802 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848000803 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 271848000804 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271848000805 carboxyltransferase (CT) interaction site; other site 271848000806 biotinylation site [posttranslational modification]; other site 271848000807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848000808 enoyl-CoA hydratase; Provisional; Region: PRK07468 271848000809 substrate binding site [chemical binding]; other site 271848000810 oxyanion hole (OAH) forming residues; other site 271848000811 trimer interface [polypeptide binding]; other site 271848000812 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848000813 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848000814 active site 271848000815 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 271848000816 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848000817 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848000818 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848000819 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 271848000820 NAD(P) binding site [chemical binding]; other site 271848000821 substrate binding site [chemical binding]; other site 271848000822 homotetramer interface [polypeptide binding]; other site 271848000823 active site 271848000824 homodimer interface [polypeptide binding]; other site 271848000825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848000826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848000827 active site 271848000828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848000829 Helix-turn-helix domains; Region: HTH; cl00088 271848000830 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 271848000831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848000832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848000834 putative substrate translocation pore; other site 271848000835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000836 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 271848000837 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 271848000838 ATP binding site [chemical binding]; other site 271848000839 substrate interface [chemical binding]; other site 271848000840 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848000841 active site residue [active] 271848000842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848000843 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 271848000844 putative catalytic residues [active] 271848000845 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 271848000846 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271848000847 catalytic triad [active] 271848000848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000849 S-adenosylmethionine binding site [chemical binding]; other site 271848000850 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 271848000851 homodimer interaction site [polypeptide binding]; other site 271848000852 cofactor binding site; other site 271848000853 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848000854 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848000855 Ubiquitin-like proteins; Region: UBQ; cl00155 271848000856 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848000857 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 271848000858 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271848000859 active site 271848000860 uncharacterized xylulose kinase-like proteins, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 271848000861 N- and C-terminal domain interface [polypeptide binding]; other site 271848000862 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 271848000863 active site 271848000864 catalytic site [active] 271848000865 metal binding site [ion binding]; metal-binding site 271848000866 xylulose binding site [chemical binding]; other site 271848000867 ATP binding site [chemical binding]; other site 271848000868 putative homodimer interface [polypeptide binding]; other site 271848000869 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 271848000870 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848000871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848000872 catalytic residue [active] 271848000873 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 271848000874 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 271848000875 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848000876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848000877 catalytic residue [active] 271848000878 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 271848000879 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 271848000880 Integral membrane protein TerC family; Region: TerC; cl10468 271848000881 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 271848000882 Helix-turn-helix domains; Region: HTH; cl00088 271848000883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000884 dimerization interface [polypeptide binding]; other site 271848000885 Flavin Reductases; Region: FlaRed; cl00801 271848000886 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 271848000887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000888 active site 271848000889 phosphorylation site [posttranslational modification] 271848000890 intermolecular recognition site; other site 271848000891 dimerization interface [polypeptide binding]; other site 271848000892 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848000893 DNA binding residues [nucleotide binding] 271848000894 dimerization interface [polypeptide binding]; other site 271848000895 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848000896 FAD binding domain; Region: FAD_binding_4; pfam01565 271848000897 Berberine and berberine like; Region: BBE; pfam08031 271848000898 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 271848000899 classical (c) SDRs; Region: SDR_c; cd05233 271848000900 NAD(P) binding site [chemical binding]; other site 271848000901 active site 271848000902 Amidase; Region: Amidase; cl11426 271848000903 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848000904 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848000905 active site 271848000906 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271848000907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848000908 putative active site [active] 271848000909 heme pocket [chemical binding]; other site 271848000910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848000911 dimer interface [polypeptide binding]; other site 271848000912 phosphorylation site [posttranslational modification] 271848000913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848000914 ATP binding site [chemical binding]; other site 271848000915 Mg2+ binding site [ion binding]; other site 271848000916 G-X-G motif; other site 271848000917 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848000918 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848000919 active site 1 [active] 271848000920 dimer interface [polypeptide binding]; other site 271848000921 hexamer interface [polypeptide binding]; other site 271848000922 active site 2 [active] 271848000923 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 271848000924 inter-subunit interface; other site 271848000925 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 271848000926 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 271848000927 [2Fe-2S] cluster binding site [ion binding]; other site 271848000928 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 271848000929 putative alpha subunit interface [polypeptide binding]; other site 271848000930 putative active site [active] 271848000931 putative substrate binding site [chemical binding]; other site 271848000932 Fe binding site [ion binding]; other site 271848000933 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 271848000934 Helix-turn-helix domains; Region: HTH; cl00088 271848000935 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 271848000936 substrate binding pocket [chemical binding]; other site 271848000937 dimerization interface [polypeptide binding]; other site 271848000938 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 271848000939 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 271848000940 FMN-binding pocket [chemical binding]; other site 271848000941 flavin binding motif; other site 271848000942 phosphate binding motif [ion binding]; other site 271848000943 beta-alpha-beta structure motif; other site 271848000944 NAD binding pocket [chemical binding]; other site 271848000945 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848000946 catalytic loop [active] 271848000947 iron binding site [ion binding]; other site 271848000948 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848000949 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848000950 NAD(P) binding site [chemical binding]; other site 271848000951 catalytic residues [active] 271848000952 choline dehydrogenase; Validated; Region: PRK02106 271848000953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000954 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848000955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848000957 putative substrate translocation pore; other site 271848000958 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848000959 trimer interface [polypeptide binding]; other site 271848000960 eyelet of channel; other site 271848000961 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 271848000962 Helix-turn-helix domains; Region: HTH; cl00088 271848000963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000964 dimerization interface [polypeptide binding]; other site 271848000965 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848000966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000967 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 271848000968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000969 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 271848000970 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848000971 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848000972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000973 putative substrate translocation pore; other site 271848000974 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 271848000975 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 271848000976 active site 271848000977 homodimer interface [polypeptide binding]; other site 271848000978 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 271848000979 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 271848000980 DXD motif; other site 271848000981 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 271848000982 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 271848000983 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 271848000984 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 271848000985 glutaminase active site [active] 271848000986 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 271848000987 dimer interface [polypeptide binding]; other site 271848000988 active site 271848000989 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 271848000990 dimer interface [polypeptide binding]; other site 271848000991 active site 271848000992 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 271848000993 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 271848000994 NADP binding site [chemical binding]; other site 271848000995 homodimer interface [polypeptide binding]; other site 271848000996 active site 271848000997 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848000998 Helix-turn-helix domains; Region: HTH; cl00088 271848000999 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 271848001000 dimerization interface [polypeptide binding]; other site 271848001001 substrate binding pocket [chemical binding]; other site 271848001002 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 271848001003 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 271848001004 ATP-binding site [chemical binding]; other site 271848001005 Gluconate-6-phosphate binding site [chemical binding]; other site 271848001006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848001007 D-galactonate transporter; Region: 2A0114; TIGR00893 271848001008 putative substrate translocation pore; other site 271848001009 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848001010 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848001011 Helix-turn-helix domains; Region: HTH; cl00088 271848001012 HTH-like domain; Region: HTH_21; pfam13276 271848001013 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848001014 MULE transposase domain; Region: MULE; pfam10551 271848001015 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 271848001016 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848001017 Cupin domain; Region: Cupin_2; cl09118 271848001018 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 271848001019 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271848001020 Protein of unknown function, DUF488; Region: DUF488; cl01246 271848001021 Protein of unknown function, DUF; Region: DUF411; cl01142 271848001022 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848001023 HTH-like domain; Region: HTH_21; pfam13276 271848001024 Integrase core domain; Region: rve; cl01316 271848001025 Integrase core domain; Region: rve_3; cl15866 271848001026 Helix-turn-helix domains; Region: HTH; cl00088 271848001027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848001028 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848001029 Uncharacterized conserved protein [Function unknown]; Region: COG3391 271848001030 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848001031 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848001032 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848001033 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 271848001034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848001035 dimerization interface [polypeptide binding]; other site 271848001036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848001037 dimer interface [polypeptide binding]; other site 271848001038 phosphorylation site [posttranslational modification] 271848001039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848001040 ATP binding site [chemical binding]; other site 271848001041 Mg2+ binding site [ion binding]; other site 271848001042 G-X-G motif; other site 271848001043 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 271848001044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848001045 active site 271848001046 phosphorylation site [posttranslational modification] 271848001047 intermolecular recognition site; other site 271848001048 dimerization interface [polypeptide binding]; other site 271848001049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848001050 DNA binding site [nucleotide binding] 271848001051 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 271848001052 active site 271848001053 catalytic triad [active] 271848001054 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 271848001055 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 271848001056 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 271848001057 putative uracil binding site [chemical binding]; other site 271848001058 putative active site [active] 271848001059 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 271848001060 intersubunit interface [polypeptide binding]; other site 271848001061 active site 271848001062 Zn2+ binding site [ion binding]; other site 271848001063 Ferritin-like; Region: Ferritin-like; pfam12902 271848001064 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848001065 active site 271848001066 metal binding site [ion binding]; metal-binding site 271848001067 Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins; Region: PLDc_DNaseII_1; cd09120 271848001068 Deoxyribonuclease II; Region: DNase_II; pfam03265 271848001069 putative active site [active] 271848001070 catalytic site [active] 271848001071 Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins; Region: PLDc_DNaseII_2; cd09121 271848001072 putative active site [active] 271848001073 catalytic site [active] 271848001074 Cation efflux family; Region: Cation_efflux; cl00316 271848001075 Cation efflux family; Region: Cation_efflux; cl00316 271848001076 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 271848001077 putative metal binding site [ion binding]; other site 271848001078 putative homodimer interface [polypeptide binding]; other site 271848001079 putative homotetramer interface [polypeptide binding]; other site 271848001080 putative homodimer-homodimer interface [polypeptide binding]; other site 271848001081 putative allosteric switch controlling residues; other site 271848001082 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 271848001083 Chain length determinant protein; Region: Wzz; cl15801 271848001084 tyrosine kinase; Provisional; Region: PRK11519 271848001085 Chain length determinant protein; Region: Wzz; cl15801 271848001086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848001087 Phospholipid methyltransferase; Region: PEMT; cl00763 271848001088 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848001089 peptidase domain interface [polypeptide binding]; other site 271848001090 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848001091 active site 271848001092 catalytic triad [active] 271848001093 calcium binding site [ion binding]; other site 271848001094 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 271848001095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848001096 metal binding site [ion binding]; metal-binding site 271848001097 active site 271848001098 I-site; other site 271848001099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848001100 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 271848001101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848001103 short chain dehydrogenase; Provisional; Region: PRK06181 271848001104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001105 NAD(P) binding site [chemical binding]; other site 271848001106 active site 271848001107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848001108 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848001109 Helix-turn-helix domains; Region: HTH; cl00088 271848001110 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848001111 putative effector binding pocket; other site 271848001112 dimerization interface [polypeptide binding]; other site 271848001113 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848001114 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 271848001115 putative C-terminal domain interface [polypeptide binding]; other site 271848001116 putative GSH binding site (G-site) [chemical binding]; other site 271848001117 putative dimer interface [polypeptide binding]; other site 271848001118 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 271848001119 putative N-terminal domain interface [polypeptide binding]; other site 271848001120 putative dimer interface [polypeptide binding]; other site 271848001121 putative substrate binding pocket (H-site) [chemical binding]; other site 271848001122 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271848001123 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 271848001124 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 271848001125 FAD binding pocket [chemical binding]; other site 271848001126 FAD binding motif [chemical binding]; other site 271848001127 phosphate binding motif [ion binding]; other site 271848001128 beta-alpha-beta structure motif; other site 271848001129 NAD binding pocket [chemical binding]; other site 271848001130 Heme binding pocket [chemical binding]; other site 271848001131 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848001132 catalytic loop [active] 271848001133 iron binding site [ion binding]; other site 271848001134 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 271848001135 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 271848001136 Nucleoside recognition; Region: Gate; cl00486 271848001137 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 271848001138 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271848001139 catalytic residue [active] 271848001140 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 271848001141 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271848001142 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 271848001143 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 271848001144 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 271848001145 active site 271848001146 catalytic motif [active] 271848001147 Zn binding site [ion binding]; other site 271848001148 periplasmic protein; Provisional; Region: PRK10568 271848001149 BON domain; Region: BON; cl02771 271848001150 BON domain; Region: BON; cl02771 271848001151 6-phosphofructokinase 2; Provisional; Region: PRK10294 271848001152 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 271848001153 putative substrate binding site [chemical binding]; other site 271848001154 putative ATP binding site [chemical binding]; other site 271848001155 Acetokinase family; Region: Acetate_kinase; cl01029 271848001156 acetate kinase; Region: ackA; TIGR00016 271848001157 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 271848001158 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 271848001159 dimer interaction site [polypeptide binding]; other site 271848001160 substrate-binding tunnel; other site 271848001161 active site 271848001162 catalytic site [active] 271848001163 substrate binding site [chemical binding]; other site 271848001164 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 271848001165 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 271848001166 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 271848001167 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 271848001168 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 271848001169 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271848001170 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 271848001171 alpha subunit interaction interface [polypeptide binding]; other site 271848001172 Walker A motif; other site 271848001173 ATP binding site [chemical binding]; other site 271848001174 Walker B motif; other site 271848001175 inhibitor binding site; inhibition site 271848001176 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271848001177 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 271848001178 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 271848001179 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 271848001180 ATP synthase A chain; Region: ATP-synt_A; cl00413 271848001181 ATP synthase subunit C; Region: ATP-synt_C; cl00466 271848001182 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 271848001183 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271848001184 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 271848001185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848001186 Walker A motif; other site 271848001187 ATP binding site [chemical binding]; other site 271848001188 Walker B motif; other site 271848001189 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271848001190 ATP synthase; Region: ATP-synt; cl00365 271848001191 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 271848001192 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 271848001193 NAD binding site [chemical binding]; other site 271848001194 substrate binding site [chemical binding]; other site 271848001195 catalytic Zn binding site [ion binding]; other site 271848001196 tetramer interface [polypeptide binding]; other site 271848001197 structural Zn binding site [ion binding]; other site 271848001198 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848001199 MULE transposase domain; Region: MULE; pfam10551 271848001200 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848001201 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 271848001202 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848001203 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848001204 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 271848001205 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 271848001206 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848001207 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848001208 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 271848001209 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848001210 Walker A/P-loop; other site 271848001211 ATP binding site [chemical binding]; other site 271848001212 Q-loop/lid; other site 271848001213 ABC transporter signature motif; other site 271848001214 Walker B; other site 271848001215 D-loop; other site 271848001216 H-loop/switch region; other site 271848001217 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848001218 Walker A/P-loop; other site 271848001219 ATP binding site [chemical binding]; other site 271848001220 Q-loop/lid; other site 271848001221 ABC transporter signature motif; other site 271848001222 Walker B; other site 271848001223 D-loop; other site 271848001224 H-loop/switch region; other site 271848001225 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848001226 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848001227 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 271848001228 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848001229 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848001230 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848001231 Helix-turn-helix domains; Region: HTH; cl00088 271848001232 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848001233 Ligand Binding Site [chemical binding]; other site 271848001234 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 271848001235 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 271848001236 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271848001237 FtsX-like permease family; Region: FtsX; cl15850 271848001238 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848001239 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271848001240 Walker A/P-loop; other site 271848001241 ATP binding site [chemical binding]; other site 271848001242 Q-loop/lid; other site 271848001243 ABC transporter signature motif; other site 271848001244 Walker B; other site 271848001245 D-loop; other site 271848001246 H-loop/switch region; other site 271848001247 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 271848001248 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848001249 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848001250 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 271848001251 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 271848001252 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848001253 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848001254 dimer interface [polypeptide binding]; other site 271848001255 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 271848001256 putative CheW interface [polypeptide binding]; other site 271848001257 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 271848001258 ligand-binding site [chemical binding]; other site 271848001259 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 271848001260 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 271848001261 BON domain; Region: BON; cl02771 271848001262 BON domain; Region: BON; cl02771 271848001263 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271848001264 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 271848001265 Cytochrome c; Region: Cytochrom_C; cl11414 271848001266 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 271848001267 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 271848001268 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 271848001269 putative NAD(P) binding site [chemical binding]; other site 271848001270 putative substrate binding site [chemical binding]; other site 271848001271 catalytic Zn binding site [ion binding]; other site 271848001272 structural Zn binding site [ion binding]; other site 271848001273 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 271848001274 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848001275 ligand binding site [chemical binding]; other site 271848001276 flexible hinge region; other site 271848001277 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271848001278 putative switch regulator; other site 271848001279 non-specific DNA interactions [nucleotide binding]; other site 271848001280 DNA binding site [nucleotide binding] 271848001281 sequence specific DNA binding site [nucleotide binding]; other site 271848001282 putative cAMP binding site [chemical binding]; other site 271848001283 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 271848001284 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 271848001285 NAD(P) binding site [chemical binding]; other site 271848001286 homotetramer interface [polypeptide binding]; other site 271848001287 homodimer interface [polypeptide binding]; other site 271848001288 active site 271848001289 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 271848001290 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848001291 Beta-Casp domain; Region: Beta-Casp; cl12567 271848001292 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 271848001293 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848001294 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848001295 lysine transporter; Provisional; Region: PRK10836 271848001296 Spore germination protein; Region: Spore_permease; cl15802 271848001297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848001298 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848001299 Isochorismatase family; Region: Isochorismatase; pfam00857 271848001300 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 271848001301 catalytic triad [active] 271848001302 conserved cis-peptide bond; other site 271848001303 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848001304 Helix-turn-helix domains; Region: HTH; cl00088 271848001305 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848001306 substrate binding pocket [chemical binding]; other site 271848001307 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 271848001308 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848001309 putative NAD(P) binding site [chemical binding]; other site 271848001310 active site 271848001311 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 271848001312 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848001313 catalytic loop [active] 271848001314 iron binding site [ion binding]; other site 271848001315 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 271848001316 FAD binding pocket [chemical binding]; other site 271848001317 FAD binding motif [chemical binding]; other site 271848001318 phosphate binding motif [ion binding]; other site 271848001319 beta-alpha-beta structure motif; other site 271848001320 NAD binding pocket [chemical binding]; other site 271848001321 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 271848001322 inter-subunit interface; other site 271848001323 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848001324 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 271848001325 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 271848001326 putative alpha subunit interface [polypeptide binding]; other site 271848001327 putative active site [active] 271848001328 putative substrate binding site [chemical binding]; other site 271848001329 Fe binding site [ion binding]; other site 271848001330 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848001331 Helix-turn-helix domains; Region: HTH; cl00088 271848001332 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 271848001333 dimerizarion interface [polypeptide binding]; other site 271848001334 CrgA pocket; other site 271848001335 substrate binding pocket [chemical binding]; other site 271848001336 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848001337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001338 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 271848001339 active site 271848001340 FMN binding site [chemical binding]; other site 271848001341 2,4-decadienoyl-CoA binding site; other site 271848001342 catalytic residue [active] 271848001343 4Fe-4S cluster binding site [ion binding]; other site 271848001344 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 271848001345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001346 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 271848001347 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848001348 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 271848001349 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 271848001350 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 271848001351 D-pathway; other site 271848001352 Putative ubiquinol binding site [chemical binding]; other site 271848001353 Low-spin heme (heme b) binding site [chemical binding]; other site 271848001354 Putative water exit pathway; other site 271848001355 Binuclear center (heme o3/CuB) [ion binding]; other site 271848001356 K-pathway; other site 271848001357 Putative proton exit pathway; other site 271848001358 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 271848001359 Subunit I/III interface [polypeptide binding]; other site 271848001360 Subunit III/IV interface [polypeptide binding]; other site 271848001361 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 271848001362 Muconolactone delta-isomerase; Region: MIase; cl01992 271848001363 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 271848001364 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 271848001365 dimer interface [polypeptide binding]; other site 271848001366 active site 271848001367 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271848001368 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 271848001369 metal binding site [ion binding]; metal-binding site 271848001370 substrate binding pocket [chemical binding]; other site 271848001371 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848001372 Helix-turn-helix domains; Region: HTH; cl00088 271848001373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848001374 dimerization interface [polypeptide binding]; other site 271848001375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848001376 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 271848001377 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 271848001378 putative alpha subunit interface [polypeptide binding]; other site 271848001379 putative active site [active] 271848001380 putative substrate binding site [chemical binding]; other site 271848001381 Fe binding site [ion binding]; other site 271848001382 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 271848001383 inter-subunit interface; other site 271848001384 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 271848001385 [2Fe-2S] cluster binding site [ion binding]; other site 271848001386 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 271848001387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848001388 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 271848001389 HIT family signature motif; other site 271848001390 catalytic residue [active] 271848001391 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 271848001392 PLD-like domain; Region: PLDc_2; pfam13091 271848001393 putative active site [active] 271848001394 catalytic site [active] 271848001395 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 271848001396 PLD-like domain; Region: PLDc_2; pfam13091 271848001397 putative active site [active] 271848001398 catalytic site [active] 271848001399 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848001400 Protein of unknown function (DUF445); Region: DUF445; pfam04286 271848001401 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 271848001402 acetolactate synthase; Reviewed; Region: PRK08322 271848001403 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848001404 PYR/PP interface [polypeptide binding]; other site 271848001405 dimer interface [polypeptide binding]; other site 271848001406 TPP binding site [chemical binding]; other site 271848001407 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271848001408 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 271848001409 TPP-binding site [chemical binding]; other site 271848001410 dimer interface [polypeptide binding]; other site 271848001411 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848001412 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 271848001413 NAD(P) binding site [chemical binding]; other site 271848001414 catalytic residues [active] 271848001415 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 271848001416 active site 271848001417 catalytic site [active] 271848001418 Response regulator receiver domain; Region: Response_reg; pfam00072 271848001419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848001420 active site 271848001421 phosphorylation site [posttranslational modification] 271848001422 intermolecular recognition site; other site 271848001423 dimerization interface [polypeptide binding]; other site 271848001424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848001425 dimer interface [polypeptide binding]; other site 271848001426 phosphorylation site [posttranslational modification] 271848001427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848001428 ATP binding site [chemical binding]; other site 271848001429 Mg2+ binding site [ion binding]; other site 271848001430 G-X-G motif; other site 271848001431 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 271848001432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848001433 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848001434 dimer interface [polypeptide binding]; other site 271848001435 putative CheW interface [polypeptide binding]; other site 271848001436 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848001437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848001438 S-adenosylmethionine binding site [chemical binding]; other site 271848001439 TPR repeat; Region: TPR_11; pfam13414 271848001440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271848001441 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848001442 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271848001443 putative binding surface; other site 271848001444 active site 271848001445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848001446 ATP binding site [chemical binding]; other site 271848001447 Mg2+ binding site [ion binding]; other site 271848001448 G-X-G motif; other site 271848001449 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848001450 Response regulator receiver domain; Region: Response_reg; pfam00072 271848001451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848001452 active site 271848001453 phosphorylation site [posttranslational modification] 271848001454 intermolecular recognition site; other site 271848001455 dimerization interface [polypeptide binding]; other site 271848001456 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 271848001457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848001458 active site 271848001459 phosphorylation site [posttranslational modification] 271848001460 intermolecular recognition site; other site 271848001461 dimerization interface [polypeptide binding]; other site 271848001462 CheB methylesterase; Region: CheB_methylest; pfam01339 271848001463 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 271848001464 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848001465 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848001466 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 271848001467 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 271848001468 Cl- selectivity filter; other site 271848001469 Cl- binding residues [ion binding]; other site 271848001470 pore gating glutamate residue; other site 271848001471 dimer interface [polypeptide binding]; other site 271848001472 CAAX protease self-immunity; Region: Abi; cl00558 271848001473 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 271848001474 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 271848001475 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 271848001476 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 271848001477 active site 271848001478 HIGH motif; other site 271848001479 dimer interface [polypeptide binding]; other site 271848001480 KMSKS motif; other site 271848001481 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848001482 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848001483 conserved cys residue [active] 271848001484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001485 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 271848001486 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 271848001487 conserved cys residue [active] 271848001488 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 271848001489 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 271848001490 Walker A/P-loop; other site 271848001491 ATP binding site [chemical binding]; other site 271848001492 Q-loop/lid; other site 271848001493 ABC transporter signature motif; other site 271848001494 Walker B; other site 271848001495 D-loop; other site 271848001496 H-loop/switch region; other site 271848001497 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 271848001498 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 271848001499 OsmC-like protein; Region: OsmC; cl00767 271848001500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848001501 Helix-turn-helix domains; Region: HTH; cl00088 271848001502 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 271848001503 substrate binding pocket [chemical binding]; other site 271848001504 dimerization interface [polypeptide binding]; other site 271848001505 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848001506 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848001507 active site 271848001508 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 271848001509 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 271848001510 putative active site [active] 271848001511 putative substrate binding site [chemical binding]; other site 271848001512 ATP binding site [chemical binding]; other site 271848001513 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 271848001514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848001515 classical (c) SDRs; Region: SDR_c; cd05233 271848001516 NAD(P) binding site [chemical binding]; other site 271848001517 active site 271848001518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001519 short chain dehydrogenase; Validated; Region: PRK07069 271848001520 NAD(P) binding site [chemical binding]; other site 271848001521 active site 271848001522 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 271848001523 Prostaglandin dehydrogenases; Region: PGDH; cd05288 271848001524 NAD(P) binding site [chemical binding]; other site 271848001525 substrate binding site [chemical binding]; other site 271848001526 dimer interface [polypeptide binding]; other site 271848001527 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 271848001528 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 271848001529 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848001530 N-terminal plug; other site 271848001531 ligand-binding site [chemical binding]; other site 271848001532 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 271848001533 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 271848001534 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 271848001535 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 271848001536 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 271848001537 generic binding surface I; other site 271848001538 generic binding surface II; other site 271848001539 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 271848001540 putative active site [active] 271848001541 putative catalytic site [active] 271848001542 putative Mg binding site IVb [ion binding]; other site 271848001543 putative phosphate binding site [ion binding]; other site 271848001544 putative DNA binding site [nucleotide binding]; other site 271848001545 putative Mg binding site IVa [ion binding]; other site 271848001546 YCII-related domain; Region: YCII; cl00999 271848001547 YCII-related domain; Region: YCII; cl00999 271848001548 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 271848001549 putative hydrophobic ligand binding site [chemical binding]; other site 271848001550 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 271848001551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848001552 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 271848001553 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271848001554 amidase catalytic site [active] 271848001555 Zn binding residues [ion binding]; other site 271848001556 substrate binding site [chemical binding]; other site 271848001557 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 271848001558 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 271848001559 binuclear metal center [ion binding]; other site 271848001560 tricarballylate utilization protein B; Provisional; Region: PRK15033 271848001561 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 271848001562 Cysteine-rich domain; Region: CCG; pfam02754 271848001563 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 271848001564 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848001565 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 271848001566 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 271848001567 Substrate binding site; other site 271848001568 Cupin domain; Region: Cupin_2; cl09118 271848001569 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 271848001570 Bacterial sugar transferase; Region: Bac_transf; cl00939 271848001571 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 271848001572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001573 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 271848001574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001575 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271848001576 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 271848001577 active site 271848001578 polysaccharide export protein Wza; Provisional; Region: PRK15078 271848001579 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848001580 SLBB domain; Region: SLBB; pfam10531 271848001581 tyrosine kinase; Provisional; Region: PRK11519 271848001582 Chain length determinant protein; Region: Wzz; cl15801 271848001583 Chain length determinant protein; Region: Wzz; cl15801 271848001584 Chain length determinant protein; Region: Wzz; cl15801 271848001585 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848001586 P-loop; other site 271848001587 Magnesium ion binding site [ion binding]; other site 271848001588 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271848001589 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 271848001590 DXD motif; other site 271848001591 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848001592 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271848001593 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 271848001594 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271848001595 Cupin domain; Region: Cupin_2; cl09118 271848001596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848001598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001599 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 271848001600 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848001601 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848001602 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 271848001603 RES domain; Region: RES; cl02411 271848001604 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848001605 active site 271848001606 metal binding site [ion binding]; metal-binding site 271848001607 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 271848001608 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 271848001609 putative hydrophobic ligand binding site [chemical binding]; other site 271848001610 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848001611 dimerization interface [polypeptide binding]; other site 271848001612 putative DNA binding site [nucleotide binding]; other site 271848001613 putative Zn2+ binding site [ion binding]; other site 271848001614 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848001615 AMP-binding enzyme; Region: AMP-binding; cl15778 271848001616 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848001617 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848001618 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848001619 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 271848001620 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 271848001621 homodimer interface [polypeptide binding]; other site 271848001622 substrate-cofactor binding pocket; other site 271848001623 catalytic residue [active] 271848001624 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848001625 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 271848001626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001627 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 271848001628 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 271848001629 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 271848001630 active site 271848001631 catalytic residues [active] 271848001632 metal binding site [ion binding]; metal-binding site 271848001633 DmpG-like communication domain; Region: DmpG_comm; pfam07836 271848001634 Cupin domain; Region: Cupin_2; cl09118 271848001635 LysE type translocator; Region: LysE; cl00565 271848001636 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848001637 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848001638 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848001639 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 271848001640 Cupin domain; Region: Cupin_2; cl09118 271848001641 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848001642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001643 LysE type translocator; Region: LysE; cl00565 271848001644 Helix-turn-helix domains; Region: HTH; cl00088 271848001645 Winged helix-turn helix; Region: HTH_29; pfam13551 271848001646 Winged helix-turn helix; Region: HTH_33; pfam13592 271848001647 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 271848001648 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271848001649 phosphate binding site [ion binding]; other site 271848001650 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 271848001651 putative deacylase active site [active] 271848001652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848001653 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 271848001654 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 271848001655 active site 271848001656 catalytic site [active] 271848001657 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 271848001658 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 271848001659 thiamine phosphate binding site [chemical binding]; other site 271848001660 active site 271848001661 pyrophosphate binding site [ion binding]; other site 271848001662 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 271848001663 Domain of unknown function DUF21; Region: DUF21; pfam01595 271848001664 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 271848001665 Transporter associated domain; Region: CorC_HlyC; cl08393 271848001666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848001667 dimer interface [polypeptide binding]; other site 271848001668 phosphorylation site [posttranslational modification] 271848001669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 271848001670 EamA-like transporter family; Region: EamA; cl01037 271848001671 Helix-turn-helix domains; Region: HTH; cl00088 271848001672 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848001673 dimerization interface [polypeptide binding]; other site 271848001674 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848001675 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848001676 dimer interface [polypeptide binding]; other site 271848001677 hexamer interface [polypeptide binding]; other site 271848001678 active site 2 [active] 271848001679 CHAD domain; Region: CHAD; cl10506 271848001680 Helix-turn-helix domains; Region: HTH; cl00088 271848001681 TOBE domain; Region: TOBE_2; cl01440 271848001682 TOBE domain; Region: TOBE_2; cl01440 271848001683 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848001684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848001685 Walker A/P-loop; other site 271848001686 ATP binding site [chemical binding]; other site 271848001687 Q-loop/lid; other site 271848001688 ABC transporter signature motif; other site 271848001689 Walker B; other site 271848001690 D-loop; other site 271848001691 H-loop/switch region; other site 271848001692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848001693 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 271848001694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848001695 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 271848001696 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848001697 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 271848001698 OsmC-like protein; Region: OsmC; cl00767 271848001699 Helix-turn-helix domains; Region: HTH; cl00088 271848001700 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 271848001701 putative active site [active] 271848001702 putative substrate binding site [chemical binding]; other site 271848001703 ATP binding site [chemical binding]; other site 271848001704 AMP nucleosidase; Provisional; Region: PRK08292 271848001705 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 271848001706 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 271848001707 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271848001708 DNA polymerase I; Provisional; Region: PRK05755 271848001709 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 271848001710 active site 271848001711 metal binding site 1 [ion binding]; metal-binding site 271848001712 putative 5' ssDNA interaction site; other site 271848001713 metal binding site 3; metal-binding site 271848001714 metal binding site 2 [ion binding]; metal-binding site 271848001715 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 271848001716 putative DNA binding site [nucleotide binding]; other site 271848001717 putative metal binding site [ion binding]; other site 271848001718 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 271848001719 active site 271848001720 catalytic site [active] 271848001721 substrate binding site [chemical binding]; other site 271848001722 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 271848001723 active site 271848001724 DNA binding site [nucleotide binding] 271848001725 catalytic site [active] 271848001726 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 271848001727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848001728 Predicted membrane protein [Function unknown]; Region: COG4655 271848001729 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 271848001730 Dienelactone hydrolase family; Region: DLH; pfam01738 271848001731 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848001732 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 271848001733 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 271848001734 active site residue [active] 271848001735 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 271848001736 active site residue [active] 271848001737 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848001738 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 271848001739 [2Fe-2S] cluster binding site [ion binding]; other site 271848001740 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 271848001741 alpha subunit interface [polypeptide binding]; other site 271848001742 active site 271848001743 substrate binding site [chemical binding]; other site 271848001744 Fe binding site [ion binding]; other site 271848001745 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 271848001746 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 271848001747 substrate binding pocket [chemical binding]; other site 271848001748 chain length determination region; other site 271848001749 substrate-Mg2+ binding site; other site 271848001750 catalytic residues [active] 271848001751 aspartate-rich region 1; other site 271848001752 active site lid residues [active] 271848001753 aspartate-rich region 2; other site 271848001754 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 271848001755 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 271848001756 TPP-binding site; other site 271848001757 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271848001758 PYR/PP interface [polypeptide binding]; other site 271848001759 dimer interface [polypeptide binding]; other site 271848001760 TPP binding site [chemical binding]; other site 271848001761 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848001762 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 271848001763 UGMP family protein; Validated; Region: PRK09604 271848001764 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 271848001765 HI0933-like protein; Region: HI0933_like; pfam03486 271848001766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001767 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 271848001768 GatB domain; Region: GatB_Yqey; cl11497 271848001769 DNA primase; Validated; Region: dnaG; PRK05667 271848001770 CHC2 zinc finger; Region: zf-CHC2; cl15369 271848001771 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 271848001772 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 271848001773 active site 271848001774 metal binding site [ion binding]; metal-binding site 271848001775 interdomain interaction site; other site 271848001776 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 271848001777 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 271848001778 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 271848001779 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 271848001780 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271848001781 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 271848001782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848001783 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271848001784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848001785 DNA binding residues [nucleotide binding] 271848001786 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 271848001787 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 271848001788 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848001789 active site 271848001790 DNA binding site [nucleotide binding] 271848001791 Int/Topo IB signature motif; other site 271848001792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 271848001793 Integrase core domain; Region: rve; cl01316 271848001794 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848001795 MULE transposase domain; Region: MULE; pfam10551 271848001796 OpgC protein; Region: OpgC_C; cl00792 271848001797 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271848001798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848001799 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 271848001800 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 271848001801 NAD-dependent deacetylase; Provisional; Region: PRK05333 271848001802 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 271848001803 NAD+ binding site [chemical binding]; other site 271848001804 substrate binding site [chemical binding]; other site 271848001805 Zn binding site [ion binding]; other site 271848001806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848001807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001808 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 271848001809 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 271848001810 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848001811 Cupin domain; Region: Cupin_2; cl09118 271848001812 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848001813 Peptidase family M23; Region: Peptidase_M23; pfam01551 271848001814 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848001815 E3 interaction surface; other site 271848001816 lipoyl attachment site [posttranslational modification]; other site 271848001817 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271848001818 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 271848001819 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 271848001820 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848001821 N-terminal plug; other site 271848001822 ligand-binding site [chemical binding]; other site 271848001823 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 271848001824 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848001825 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848001826 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 271848001827 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848001828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848001829 DNA-binding site [nucleotide binding]; DNA binding site 271848001830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848001831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848001832 homodimer interface [polypeptide binding]; other site 271848001833 catalytic residue [active] 271848001834 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 271848001835 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 271848001836 Walker A/P-loop; other site 271848001837 ATP binding site [chemical binding]; other site 271848001838 Q-loop/lid; other site 271848001839 ABC transporter signature motif; other site 271848001840 Walker B; other site 271848001841 D-loop; other site 271848001842 H-loop/switch region; other site 271848001843 TOBE domain; Region: TOBE_2; cl01440 271848001844 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 271848001845 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848001846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848001847 dimer interface [polypeptide binding]; other site 271848001848 conserved gate region; other site 271848001849 putative PBP binding loops; other site 271848001850 ABC-ATPase subunit interface; other site 271848001851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848001852 putative PBP binding loops; other site 271848001853 dimer interface [polypeptide binding]; other site 271848001854 ABC-ATPase subunit interface; other site 271848001855 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848001856 peptidase domain interface [polypeptide binding]; other site 271848001857 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848001858 active site 271848001859 catalytic triad [active] 271848001860 calcium binding site [ion binding]; other site 271848001861 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 271848001862 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 271848001863 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848001864 Cytochrome c; Region: Cytochrom_C; cl11414 271848001865 Cytochrome c; Region: Cytochrom_C; cl11414 271848001866 aconitate hydratase; Provisional; Region: acnA; PRK12881 271848001867 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 271848001868 substrate binding site [chemical binding]; other site 271848001869 ligand binding site [chemical binding]; other site 271848001870 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 271848001871 substrate binding site [chemical binding]; other site 271848001872 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 271848001873 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848001874 malate dehydrogenase; Provisional; Region: PRK05442 271848001875 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 271848001876 NAD(P) binding site [chemical binding]; other site 271848001877 dimer interface [polypeptide binding]; other site 271848001878 malate binding site [chemical binding]; other site 271848001879 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 271848001880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848001881 DNA-binding site [nucleotide binding]; DNA binding site 271848001882 UTRA domain; Region: UTRA; cl01230 271848001883 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 271848001884 Iron-sulfur protein interface; other site 271848001885 proximal quinone binding site [chemical binding]; other site 271848001886 SdhD (CybS) interface [polypeptide binding]; other site 271848001887 proximal heme binding site [chemical binding]; other site 271848001888 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 271848001889 SdhC subunit interface [polypeptide binding]; other site 271848001890 proximal heme binding site [chemical binding]; other site 271848001891 cardiolipin binding site; other site 271848001892 Iron-sulfur protein interface; other site 271848001893 proximal quinone binding site [chemical binding]; other site 271848001894 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 271848001895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001896 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 271848001897 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271848001898 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 271848001899 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 271848001900 dimer interface [polypeptide binding]; other site 271848001901 Citrate synthase; Region: Citrate_synt; pfam00285 271848001902 active site 271848001903 citrylCoA binding site [chemical binding]; other site 271848001904 NADH binding [chemical binding]; other site 271848001905 cationic pore residues; other site 271848001906 oxalacetate/citrate binding site [chemical binding]; other site 271848001907 coenzyme A binding site [chemical binding]; other site 271848001908 catalytic triad [active] 271848001909 Cupin domain; Region: Cupin_2; cl09118 271848001910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848001911 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 271848001912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848001913 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 271848001914 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 271848001915 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 271848001916 dimer interface [polypeptide binding]; other site 271848001917 TPP-binding site [chemical binding]; other site 271848001918 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 271848001919 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848001920 Helix-turn-helix domains; Region: HTH; cl00088 271848001921 AsnC family; Region: AsnC_trans_reg; pfam01037 271848001922 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 271848001923 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 271848001924 substrate binding site [chemical binding]; other site 271848001925 ligand binding site [chemical binding]; other site 271848001926 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 271848001927 substrate binding site [chemical binding]; other site 271848001928 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 271848001929 tartrate dehydrogenase; Provisional; Region: PRK08194 271848001930 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 271848001931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001932 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 271848001933 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 271848001934 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 271848001935 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 271848001936 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 271848001937 dimerization interface 3.5A [polypeptide binding]; other site 271848001938 active site 271848001939 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 271848001940 active site 271848001941 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 271848001942 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 271848001943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848001944 catalytic residue [active] 271848001945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848001946 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 271848001947 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 271848001948 substrate binding site [chemical binding]; other site 271848001949 active site 271848001950 catalytic residues [active] 271848001951 heterodimer interface [polypeptide binding]; other site 271848001952 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 271848001953 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848001954 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 271848001955 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848001956 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848001957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 271848001958 Colicin V production protein; Region: Colicin_V; cl00567 271848001959 amidophosphoribosyltransferase; Provisional; Region: PRK09246 271848001960 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 271848001961 active site 271848001962 tetramer interface [polypeptide binding]; other site 271848001963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848001964 active site 271848001965 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 271848001966 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 271848001967 homodimer interface [polypeptide binding]; other site 271848001968 substrate-cofactor binding pocket; other site 271848001969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848001970 catalytic residue [active] 271848001971 Cupin domain; Region: Cupin_2; cl09118 271848001972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001973 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 271848001974 NAD(P) binding site [chemical binding]; other site 271848001975 active site 271848001976 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 271848001977 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 271848001978 NADP-binding site; other site 271848001979 homotetramer interface [polypeptide binding]; other site 271848001980 substrate binding site [chemical binding]; other site 271848001981 homodimer interface [polypeptide binding]; other site 271848001982 active site 271848001983 OpgC protein; Region: OpgC_C; cl00792 271848001984 MatE; Region: MatE; cl10513 271848001985 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848001986 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 271848001987 putative ADP-binding pocket [chemical binding]; other site 271848001988 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271848001989 OpgC protein; Region: OpgC_C; cl00792 271848001990 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271848001991 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 271848001992 active site 271848001993 tetramer interface; other site 271848001994 OpgC protein; Region: OpgC_C; cl00792 271848001995 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848001996 trimer interface [polypeptide binding]; other site 271848001997 eyelet of channel; other site 271848001998 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 271848001999 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 271848002000 active site 271848002001 Zn binding site [ion binding]; other site 271848002002 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 271848002003 putative active site [active] 271848002004 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 271848002005 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 271848002006 [4Fe-4S] binding site [ion binding]; other site 271848002007 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848002008 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 271848002009 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 271848002010 molybdopterin cofactor binding site; other site 271848002011 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 271848002012 4Fe-4S binding domain; Region: Fer4; cl02805 271848002013 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 271848002014 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271848002015 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 271848002016 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 271848002017 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 271848002018 selenocysteine synthase; Provisional; Region: PRK04311 271848002019 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848002020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848002021 catalytic residue [active] 271848002022 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 271848002023 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 271848002024 G1 box; other site 271848002025 putative GEF interaction site [polypeptide binding]; other site 271848002026 GTP/Mg2+ binding site [chemical binding]; other site 271848002027 Switch I region; other site 271848002028 G2 box; other site 271848002029 G3 box; other site 271848002030 Switch II region; other site 271848002031 G4 box; other site 271848002032 G5 box; other site 271848002033 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 271848002034 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 271848002035 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 271848002036 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 271848002037 OpgC protein; Region: OpgC_C; cl00792 271848002038 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271848002039 Helix-turn-helix domains; Region: HTH; cl00088 271848002040 HTH-like domain; Region: HTH_21; pfam13276 271848002041 Integrase core domain; Region: rve; cl01316 271848002042 Avidin family; Region: Avidin; pfam01382 271848002043 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271848002044 Amidase; Region: Amidase; cl11426 271848002045 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 271848002046 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 271848002047 Fibronectin type III-like domain; Region: Fn3-like; cl15273 271848002048 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848002049 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848002050 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 271848002051 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 271848002052 FMN-binding pocket [chemical binding]; other site 271848002053 flavin binding motif; other site 271848002054 phosphate binding motif [ion binding]; other site 271848002055 beta-alpha-beta structure motif; other site 271848002056 NAD binding pocket [chemical binding]; other site 271848002057 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848002058 catalytic loop [active] 271848002059 iron binding site [ion binding]; other site 271848002060 benzoate transport; Region: 2A0115; TIGR00895 271848002061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002062 putative substrate translocation pore; other site 271848002063 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 271848002064 active site 271848002065 nucleophile elbow; other site 271848002066 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271848002067 Cu(I) binding site [ion binding]; other site 271848002068 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 271848002069 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 271848002070 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 271848002071 putative sugar binding sites [chemical binding]; other site 271848002072 Q-X-W motif; other site 271848002073 Galactose oxidase, central domain; Region: Kelch_3; cl02701 271848002074 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 271848002075 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271848002076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002077 active site 271848002078 phosphorylation site [posttranslational modification] 271848002079 intermolecular recognition site; other site 271848002080 dimerization interface [polypeptide binding]; other site 271848002081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271848002082 Zn2+ binding site [ion binding]; other site 271848002083 Mg2+ binding site [ion binding]; other site 271848002084 Uncharacterized conserved protein [Function unknown]; Region: COG3287 271848002085 FIST N domain; Region: FIST; cl10701 271848002086 FIST C domain; Region: FIST_C; pfam10442 271848002087 sensory histidine kinase AtoS; Provisional; Region: PRK11360 271848002088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002089 ATP binding site [chemical binding]; other site 271848002090 Mg2+ binding site [ion binding]; other site 271848002091 G-X-G motif; other site 271848002092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 271848002093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002094 putative substrate translocation pore; other site 271848002095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848002097 Helix-turn-helix domains; Region: HTH; cl00088 271848002098 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848002099 putative effector binding pocket; other site 271848002100 dimerization interface [polypeptide binding]; other site 271848002101 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848002102 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848002103 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848002104 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 271848002105 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 271848002106 type III secretion system ATPase; Provisional; Region: PRK09099 271848002107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848002108 Walker A motif; other site 271848002109 ATP binding site [chemical binding]; other site 271848002110 Walker B motif; other site 271848002111 type III secretion system protein HrpB; Validated; Region: PRK09098 271848002112 type III secretion protein HrpB4; Region: HrpB4; TIGR02560 271848002113 Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502 271848002114 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 271848002115 Bacterial type III secretion protein (HrpB2); Region: HrpB2; cl09721 271848002116 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 271848002117 type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561 271848002118 type III secretion system protein HrcU; Validated; Region: PRK09108 271848002119 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271848002120 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 271848002121 FHIPEP family; Region: FHIPEP; pfam00771 271848002122 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 271848002123 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 271848002124 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271848002125 FliP family; Region: FliP; cl00593 271848002126 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 271848002127 Tir chaperone protein (CesT) family; Region: CesT; cl08444 271848002128 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848002129 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 271848002130 sensory histidine kinase CreC; Provisional; Region: PRK11100 271848002131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 271848002132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848002133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002134 active site 271848002135 phosphorylation site [posttranslational modification] 271848002136 intermolecular recognition site; other site 271848002137 dimerization interface [polypeptide binding]; other site 271848002138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848002139 DNA binding site [nucleotide binding] 271848002140 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 271848002141 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 271848002142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848002143 Walker A motif; other site 271848002144 ATP binding site [chemical binding]; other site 271848002145 Walker B motif; other site 271848002146 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 271848002147 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848002148 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 271848002149 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 271848002150 Type II/IV secretion system protein; Region: T2SE; pfam00437 271848002151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848002152 Walker A motif; other site 271848002153 ATP binding site [chemical binding]; other site 271848002154 Walker B motif; other site 271848002155 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848002156 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848002157 PilS N terminal; Region: PilS; pfam08805 271848002158 PilM; Region: PilM; pfam07419 271848002159 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 271848002160 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 271848002161 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848002162 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848002163 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848002164 Arginase family; Region: Arginase; cl00306 271848002165 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848002166 Helix-turn-helix domains; Region: HTH; cl00088 271848002167 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848002168 dimerization interface [polypeptide binding]; other site 271848002169 AAA domain; Region: AAA_32; pfam13654 271848002170 ATP-dependent protease Lon; Provisional; Region: PRK13765 271848002171 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271848002172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848002173 non-specific DNA binding site [nucleotide binding]; other site 271848002174 salt bridge; other site 271848002175 sequence-specific DNA binding site [nucleotide binding]; other site 271848002176 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 271848002177 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 271848002178 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 271848002179 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 271848002180 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 271848002181 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 271848002182 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 271848002183 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 271848002184 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 271848002185 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 271848002186 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 271848002187 DXD motif; other site 271848002188 PilZ domain; Region: PilZ; cl01260 271848002189 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 271848002190 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848002191 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 271848002192 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 271848002193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848002194 substrate binding pocket [chemical binding]; other site 271848002195 membrane-bound complex binding site; other site 271848002196 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 271848002197 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 271848002198 Walker A/P-loop; other site 271848002199 ATP binding site [chemical binding]; other site 271848002200 Q-loop/lid; other site 271848002201 ABC transporter signature motif; other site 271848002202 Walker B; other site 271848002203 D-loop; other site 271848002204 H-loop/switch region; other site 271848002205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848002206 dimer interface [polypeptide binding]; other site 271848002207 conserved gate region; other site 271848002208 putative PBP binding loops; other site 271848002209 ABC-ATPase subunit interface; other site 271848002210 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 271848002211 putative active site [active] 271848002212 putative FMN binding site [chemical binding]; other site 271848002213 putative substrate binding site [chemical binding]; other site 271848002214 putative catalytic residue [active] 271848002215 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848002216 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848002217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848002218 DNA binding residues [nucleotide binding] 271848002219 dimerization interface [polypeptide binding]; other site 271848002220 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848002221 Phosphate transporter family; Region: PHO4; cl00396 271848002222 Phosphate transporter family; Region: PHO4; cl00396 271848002223 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 271848002224 putative hydrophobic ligand binding site [chemical binding]; other site 271848002225 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848002226 Helix-turn-helix domains; Region: HTH; cl00088 271848002227 AsnC family; Region: AsnC_trans_reg; pfam01037 271848002228 LysE type translocator; Region: LysE; cl00565 271848002229 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848002230 peptidase domain interface [polypeptide binding]; other site 271848002231 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848002232 active site 271848002233 catalytic triad [active] 271848002234 calcium binding site [ion binding]; other site 271848002235 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 271848002236 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 271848002237 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 271848002238 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271848002239 phosphate binding site [ion binding]; other site 271848002240 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848002241 Helix-turn-helix domains; Region: HTH; cl00088 271848002242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848002243 dimerization interface [polypeptide binding]; other site 271848002244 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 271848002245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002246 putative substrate translocation pore; other site 271848002247 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 271848002248 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 271848002249 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 271848002250 active site 271848002251 Zn binding site [ion binding]; other site 271848002252 Helix-turn-helix domains; Region: HTH; cl00088 271848002253 DNA binding site [nucleotide binding] 271848002254 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 271848002255 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 271848002256 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 271848002257 Type III secretion needle MxiH like; Region: MxiH; cl09641 271848002258 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 271848002259 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 271848002260 transcriptional regulator InvF; Provisional; Region: PRK15340 271848002261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002262 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 271848002263 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848002264 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848002265 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 271848002266 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848002267 HrpJ-like domain; Region: HrpJ; cl15454 271848002268 type III secretion system protein InvA; Provisional; Region: PRK15337 271848002269 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 271848002270 Invasion protein B family; Region: Invas_SpaK; cl04129 271848002271 ATP synthase SpaL; Validated; Region: PRK08149 271848002272 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271848002273 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848002274 Walker A motif; other site 271848002275 ATP binding site [chemical binding]; other site 271848002276 Walker B motif; other site 271848002277 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 271848002278 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271848002279 FliP family; Region: FliP; cl00593 271848002280 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 271848002281 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 271848002282 type III secretion system protein SpaS; Validated; Region: PRK08156 271848002283 chaperone protein SicA; Provisional; Region: PRK15331 271848002284 Tetratricopeptide repeat; Region: TPR_3; pfam07720 271848002285 Tetratricopeptide repeat; Region: TPR_3; pfam07720 271848002286 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 271848002287 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 271848002288 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848002289 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 271848002290 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848002291 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271848002292 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848002293 catalytic residue [active] 271848002294 type III secretion protein BopE; Provisional; Region: PRK15278 271848002295 SopE GEF domain; Region: SopE_GEF; pfam07487 271848002296 SicP binding; Region: SicP-binding; pfam09119 271848002297 Tir chaperone protein (CesT) family; Region: CesT; cl08444 271848002298 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848002299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002300 active site 271848002301 phosphorylation site [posttranslational modification] 271848002302 intermolecular recognition site; other site 271848002303 dimerization interface [polypeptide binding]; other site 271848002304 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848002305 DNA binding residues [nucleotide binding] 271848002306 dimerization interface [polypeptide binding]; other site 271848002307 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848002308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002309 Bacterial Ig-like domain; Region: Big_5; cl01012 271848002310 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 271848002311 active site 271848002312 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 271848002313 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 271848002314 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 271848002315 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848002316 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 271848002317 PAAR motif; Region: PAAR_motif; cl15808 271848002318 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 271848002319 secreted effector protein PipB2; Provisional; Region: PRK15196 271848002320 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 271848002321 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848002322 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 271848002323 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848002324 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848002325 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 271848002326 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848002327 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848002328 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848002329 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848002330 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848002331 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848002332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848002333 Walker A motif; other site 271848002334 ATP binding site [chemical binding]; other site 271848002335 Walker B motif; other site 271848002336 arginine finger; other site 271848002337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848002338 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848002339 Walker A motif; other site 271848002340 ATP binding site [chemical binding]; other site 271848002341 Walker B motif; other site 271848002342 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848002343 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 271848002344 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848002345 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848002346 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848002347 Protein of unknown function (DUF796); Region: DUF796; cl01226 271848002348 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 271848002349 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848002350 Protein of unknown function (DUF770); Region: DUF770; cl01402 271848002351 sensory histidine kinase AtoS; Provisional; Region: PRK11360 271848002352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848002353 dimer interface [polypeptide binding]; other site 271848002354 phosphorylation site [posttranslational modification] 271848002355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 271848002356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848002357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002358 active site 271848002359 phosphorylation site [posttranslational modification] 271848002360 intermolecular recognition site; other site 271848002361 dimerization interface [polypeptide binding]; other site 271848002362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848002363 DNA binding site [nucleotide binding] 271848002364 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848002365 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 271848002366 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 271848002367 probable pectinesterase/pectinesterase inhibitor; Region: PLN02217 271848002368 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 271848002369 Haemagglutinin; Region: HIM; pfam05662 271848002370 YadA-like C-terminal region; Region: YadA; pfam03895 271848002371 ADP-heptose:LPS heptosyltransferase II; Provisional; Region: PRK10916; cl15782 271848002372 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 271848002373 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271848002374 amidase catalytic site [active] 271848002375 Zn binding residues [ion binding]; other site 271848002376 substrate binding site [chemical binding]; other site 271848002377 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 271848002378 Hep_Hag; Region: Hep_Hag; pfam05658 271848002379 Hep_Hag; Region: Hep_Hag; pfam05658 271848002380 Haemagglutinin; Region: HIM; pfam05662 271848002381 YadA-like C-terminal region; Region: YadA; pfam03895 271848002382 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271848002383 Cu(I) binding site [ion binding]; other site 271848002384 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 271848002385 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 271848002386 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848002387 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848002388 Cytochrome c; Region: Cytochrom_C; cl11414 271848002389 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 271848002390 putative hydrophobic ligand binding site [chemical binding]; other site 271848002391 protein interface [polypeptide binding]; other site 271848002392 gate; other site 271848002393 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 271848002394 Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262 271848002395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848002396 Helix-turn-helix domains; Region: HTH; cl00088 271848002397 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 271848002398 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 271848002399 homodimer interface [polypeptide binding]; other site 271848002400 NAD binding pocket [chemical binding]; other site 271848002401 ATP binding pocket [chemical binding]; other site 271848002402 Mg binding site [ion binding]; other site 271848002403 active-site loop [active] 271848002404 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 271848002405 Helix-turn-helix domains; Region: HTH; cl00088 271848002406 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 271848002407 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271848002408 putative active site [active] 271848002409 catalytic site [active] 271848002410 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 271848002411 putative active site [active] 271848002412 catalytic site [active] 271848002413 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 271848002414 Helix-turn-helix domains; Region: HTH; cl00088 271848002415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848002416 FAD dependent oxidoreductase; Region: DAO; pfam01266 271848002417 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 271848002418 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848002419 Helix-turn-helix domains; Region: HTH; cl00088 271848002420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848002421 dimerization interface [polypeptide binding]; other site 271848002422 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 271848002423 aminotransferase A; Validated; Region: PRK07683 271848002424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848002425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848002426 homodimer interface [polypeptide binding]; other site 271848002427 catalytic residue [active] 271848002428 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 271848002429 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848002430 tetrameric interface [polypeptide binding]; other site 271848002431 NAD binding site [chemical binding]; other site 271848002432 catalytic residues [active] 271848002433 ApbE family; Region: ApbE; cl00643 271848002434 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 271848002435 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 271848002436 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271848002437 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 271848002438 FAD binding pocket [chemical binding]; other site 271848002439 FAD binding motif [chemical binding]; other site 271848002440 catalytic residues [active] 271848002441 NAD binding pocket [chemical binding]; other site 271848002442 phosphate binding motif [ion binding]; other site 271848002443 beta-alpha-beta structure motif; other site 271848002444 FlgD Ig-like domain; Region: FlgD_ig; cl15790 271848002445 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 271848002446 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 271848002447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002448 active site 271848002449 phosphorylation site [posttranslational modification] 271848002450 intermolecular recognition site; other site 271848002451 dimerization interface [polypeptide binding]; other site 271848002452 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848002453 DNA binding site [nucleotide binding] 271848002454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848002455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848002456 dimer interface [polypeptide binding]; other site 271848002457 phosphorylation site [posttranslational modification] 271848002458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002459 ATP binding site [chemical binding]; other site 271848002460 Mg2+ binding site [ion binding]; other site 271848002461 G-X-G motif; other site 271848002462 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848002463 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848002464 DNA binding site [nucleotide binding] 271848002465 domain linker motif; other site 271848002466 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 271848002467 putative dimerization interface [polypeptide binding]; other site 271848002468 putative ligand binding site [chemical binding]; other site 271848002469 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 271848002470 active site 271848002471 phosphorylation site [posttranslational modification] 271848002472 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 271848002473 dimerization domain swap beta strand [polypeptide binding]; other site 271848002474 regulatory protein interface [polypeptide binding]; other site 271848002475 active site 271848002476 regulatory phosphorylation site [posttranslational modification]; other site 271848002477 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 271848002478 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 271848002479 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 271848002480 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848002481 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 271848002482 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 271848002483 putative substrate binding site [chemical binding]; other site 271848002484 putative ATP binding site [chemical binding]; other site 271848002485 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 271848002486 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 271848002487 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 271848002488 active site 271848002489 P-loop; other site 271848002490 phosphorylation site [posttranslational modification] 271848002491 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 271848002492 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848002493 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848002494 benzoate transport; Region: 2A0115; TIGR00895 271848002495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002497 putative substrate translocation pore; other site 271848002498 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 271848002499 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 271848002500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848002501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848002502 Helix-turn-helix domains; Region: HTH; cl00088 271848002503 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 271848002504 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 271848002505 ring oligomerisation interface [polypeptide binding]; other site 271848002506 ATP/Mg binding site [chemical binding]; other site 271848002507 stacking interactions; other site 271848002508 hinge regions; other site 271848002509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 271848002510 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 271848002511 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 271848002512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848002513 active site 271848002514 NAD synthetase; Reviewed; Region: nadE; PRK02628 271848002515 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 271848002516 multimer interface [polypeptide binding]; other site 271848002517 active site 271848002518 catalytic triad [active] 271848002519 protein interface 1 [polypeptide binding]; other site 271848002520 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 271848002521 homodimer interface [polypeptide binding]; other site 271848002522 NAD binding pocket [chemical binding]; other site 271848002523 ATP binding pocket [chemical binding]; other site 271848002524 Mg binding site [ion binding]; other site 271848002525 active-site loop [active] 271848002526 FOG: CBS domain [General function prediction only]; Region: COG0517 271848002527 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 271848002528 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 271848002529 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 271848002530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848002531 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 271848002532 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 271848002533 putative dimer interface [polypeptide binding]; other site 271848002534 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848002535 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 271848002536 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 271848002537 acetyl-CoA synthetase; Provisional; Region: PRK04319 271848002538 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 271848002539 AMP-binding enzyme; Region: AMP-binding; cl15778 271848002540 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848002541 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 271848002542 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 271848002543 tetramer interface [polypeptide binding]; other site 271848002544 TPP-binding site [chemical binding]; other site 271848002545 heterodimer interface [polypeptide binding]; other site 271848002546 phosphorylation loop region [posttranslational modification] 271848002547 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 271848002548 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 271848002549 alpha subunit interface [polypeptide binding]; other site 271848002550 TPP binding site [chemical binding]; other site 271848002551 heterodimer interface [polypeptide binding]; other site 271848002552 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848002553 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 271848002554 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848002555 E3 interaction surface; other site 271848002556 lipoyl attachment site [posttranslational modification]; other site 271848002557 e3 binding domain; Region: E3_binding; pfam02817 271848002558 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 271848002559 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848002560 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848002561 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848002562 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848002563 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848002564 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848002565 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848002566 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848002567 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 271848002568 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 271848002569 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 271848002570 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 271848002571 active site 271848002572 catalytic site [active] 271848002573 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 271848002574 glycogen branching enzyme; Provisional; Region: PRK05402 271848002575 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 271848002576 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 271848002577 active site 271848002578 catalytic site [active] 271848002579 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 271848002580 glycogen synthase; Provisional; Region: glgA; PRK00654 271848002581 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 271848002582 ADP-binding pocket [chemical binding]; other site 271848002583 homodimer interface [polypeptide binding]; other site 271848002584 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 271848002585 putative homodimer interface [polypeptide binding]; other site 271848002586 putative active site pocket [active] 271848002587 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 271848002588 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848002589 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 271848002590 AMP-binding enzyme; Region: AMP-binding; cl15778 271848002591 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271848002592 putative acyl-acceptor binding pocket; other site 271848002593 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848002594 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848002595 Cytochrome c; Region: Cytochrom_C; cl11414 271848002596 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 271848002597 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 271848002598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848002599 Helix-turn-helix domains; Region: HTH; cl00088 271848002600 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 271848002601 isovaleryl-CoA dehydrogenase; Region: PLN02519 271848002602 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 271848002603 substrate binding site [chemical binding]; other site 271848002604 FAD binding site [chemical binding]; other site 271848002605 catalytic base [active] 271848002606 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 271848002607 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848002608 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848002609 enoyl-CoA hydratase; Provisional; Region: PRK05995 271848002610 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848002611 substrate binding site [chemical binding]; other site 271848002612 oxyanion hole (OAH) forming residues; other site 271848002613 trimer interface [polypeptide binding]; other site 271848002614 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 271848002615 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848002616 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 271848002617 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271848002618 carboxyltransferase (CT) interaction site; other site 271848002619 biotinylation site [posttranslational modification]; other site 271848002620 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 271848002621 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 271848002622 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 271848002623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848002624 binding surface 271848002625 TPR motif; other site 271848002626 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848002627 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848002628 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 271848002629 Haemagglutinin; Region: HIM; pfam05662 271848002630 Haemagglutinin; Region: HIM; pfam05662 271848002631 Haemagglutinin; Region: HIM; pfam05662 271848002632 YadA-like C-terminal region; Region: YadA; pfam03895 271848002633 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 271848002634 Membrane transport protein; Region: Mem_trans; cl09117 271848002635 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271848002636 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 271848002637 active site 271848002638 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 271848002639 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848002640 putative metal binding site [ion binding]; other site 271848002641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848002642 dimerization interface [polypeptide binding]; other site 271848002643 putative DNA binding site [nucleotide binding]; other site 271848002644 putative Zn2+ binding site [ion binding]; other site 271848002645 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271848002646 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 271848002647 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 271848002648 Walker A/P-loop; other site 271848002649 ATP binding site [chemical binding]; other site 271848002650 Q-loop/lid; other site 271848002651 ABC transporter signature motif; other site 271848002652 Walker B; other site 271848002653 D-loop; other site 271848002654 H-loop/switch region; other site 271848002655 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 271848002656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848002657 dimer interface [polypeptide binding]; other site 271848002658 conserved gate region; other site 271848002659 putative PBP binding loops; other site 271848002660 ABC-ATPase subunit interface; other site 271848002661 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848002662 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848002663 conserved cys residue [active] 271848002664 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 271848002665 NMT1-like family; Region: NMT1_2; cl15260 271848002666 Cupin domain; Region: Cupin_2; cl09118 271848002667 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848002668 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 271848002669 putative NAD(P) binding site [chemical binding]; other site 271848002670 active site 271848002671 putative substrate binding site [chemical binding]; other site 271848002672 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 271848002673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002674 D-galactonate transporter; Region: 2A0114; TIGR00893 271848002675 putative substrate translocation pore; other site 271848002676 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 271848002677 intersubunit interface [polypeptide binding]; other site 271848002678 active site 271848002679 Zn2+ binding site [ion binding]; other site 271848002680 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 271848002681 fructose-bisphosphate aldolase; Region: PLN02858 271848002682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848002683 Transcriptional regulators [Transcription]; Region: FadR; COG2186 271848002684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848002685 DNA-binding site [nucleotide binding]; DNA binding site 271848002686 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 271848002687 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848002688 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 271848002689 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271848002690 DNA binding residues [nucleotide binding] 271848002691 putative dimer interface [polypeptide binding]; other site 271848002692 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 271848002693 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 271848002694 Leucine carboxyl methyltransferase; Region: LCM; cl01306 271848002695 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848002696 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 271848002697 active site 271848002698 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 271848002699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848002700 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848002701 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848002702 DNA binding site [nucleotide binding] 271848002703 domain linker motif; other site 271848002704 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271848002705 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 271848002706 DctM-like transporters; Region: DctM; pfam06808 271848002707 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 271848002708 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 271848002709 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 271848002710 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 271848002711 glutathione s-transferase; Provisional; Region: PTZ00057 271848002712 GSH binding site (G-site) [chemical binding]; other site 271848002713 C-terminal domain interface [polypeptide binding]; other site 271848002714 dimer interface [polypeptide binding]; other site 271848002715 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 271848002716 dimer interface [polypeptide binding]; other site 271848002717 N-terminal domain interface [polypeptide binding]; other site 271848002718 substrate binding pocket (H-site) [chemical binding]; other site 271848002719 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848002720 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848002721 hypothetical protein; Provisional; Region: PRK11239 271848002722 Protein of unknown function, DUF480; Region: DUF480; cl01209 271848002723 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848002724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002725 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848002726 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848002727 conserved cys residue [active] 271848002728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002729 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 271848002730 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 271848002731 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 271848002732 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848002733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848002734 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 271848002735 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 271848002736 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271848002737 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 271848002738 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 271848002739 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271848002740 active site 271848002741 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 271848002742 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 271848002743 DNA-binding site [nucleotide binding]; DNA binding site 271848002744 RNA-binding motif; other site 271848002745 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 271848002746 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 271848002747 OsmC-like protein; Region: OsmC; cl00767 271848002748 CHASE3 domain; Region: CHASE3; cl05000 271848002749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848002750 PAS domain; Region: PAS_9; pfam13426 271848002751 putative active site [active] 271848002752 heme pocket [chemical binding]; other site 271848002753 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271848002754 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848002755 putative active site [active] 271848002756 heme pocket [chemical binding]; other site 271848002757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848002758 dimer interface [polypeptide binding]; other site 271848002759 phosphorylation site [posttranslational modification] 271848002760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002761 ATP binding site [chemical binding]; other site 271848002762 Mg2+ binding site [ion binding]; other site 271848002763 G-X-G motif; other site 271848002764 Response regulator receiver domain; Region: Response_reg; pfam00072 271848002765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002766 active site 271848002767 phosphorylation site [posttranslational modification] 271848002768 intermolecular recognition site; other site 271848002769 dimerization interface [polypeptide binding]; other site 271848002770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002771 active site 271848002772 phosphorylation site [posttranslational modification] 271848002773 intermolecular recognition site; other site 271848002774 dimerization interface [polypeptide binding]; other site 271848002775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848002776 PAS fold; Region: PAS_3; pfam08447 271848002777 putative active site [active] 271848002778 heme pocket [chemical binding]; other site 271848002779 Histidine kinase; Region: HisKA_3; pfam07730 271848002780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002781 ATP binding site [chemical binding]; other site 271848002782 Mg2+ binding site [ion binding]; other site 271848002783 G-X-G motif; other site 271848002784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002786 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 271848002787 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848002788 active site 271848002789 DNA binding site [nucleotide binding] 271848002790 Int/Topo IB signature motif; other site 271848002791 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 271848002792 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 271848002793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848002794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848002795 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848002796 Active Sites [active] 271848002797 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 271848002798 Helix-turn-helix domains; Region: HTH; cl00088 271848002799 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 271848002800 Protein of unknown function (DUF497); Region: DUF497; cl01108 271848002801 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 271848002802 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 271848002803 Phage Terminase; Region: Terminase_1; pfam03354 271848002804 Phage-related protein [Function unknown]; Region: COG4695; cl01923 271848002805 Phage portal protein; Region: Phage_portal; pfam04860 271848002806 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 271848002807 oligomer interface [polypeptide binding]; other site 271848002808 active site residues [active] 271848002809 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 271848002810 Phage capsid family; Region: Phage_capsid; pfam05065 271848002811 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 271848002812 oligomerization interface [polypeptide binding]; other site 271848002813 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 271848002814 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 271848002815 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 271848002816 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 271848002817 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 271848002818 Phage-related minor tail protein [Function unknown]; Region: COG5281 271848002819 tape measure domain; Region: tape_meas_nterm; TIGR02675 271848002820 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 271848002821 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 271848002822 Phage minor tail protein; Region: Phage_min_tail; cl01940 271848002823 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 271848002824 Phage minor tail protein L; Region: Phage_tail_L; cl01908 271848002825 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 271848002826 MPN+ (JAMM) motif; other site 271848002827 Zinc-binding site [ion binding]; other site 271848002828 NlpC/P60 family; Region: NLPC_P60; cl11438 271848002829 Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945 271848002830 Phage-related protein, tail component [Function unknown]; Region: COG4733 271848002831 Putative phage tail protein; Region: Phage-tail_3; pfam13550 271848002832 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 271848002833 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 271848002834 Phage holin family 2; Region: Phage_holin_2; pfam04550 271848002835 Peptidase M15; Region: Peptidase_M15_3; cl01194 271848002836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848002837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002838 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 271848002839 choline dehydrogenase; Validated; Region: PRK02106 271848002840 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848002841 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848002842 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 271848002843 tetrameric interface [polypeptide binding]; other site 271848002844 NAD binding site [chemical binding]; other site 271848002845 catalytic residues [active] 271848002846 transcriptional regulator BetI; Validated; Region: PRK00767 271848002847 Helix-turn-helix domains; Region: HTH; cl00088 271848002848 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 271848002849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848002850 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 271848002851 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 271848002852 active site 271848002853 TDP-binding site; other site 271848002854 acceptor substrate-binding pocket; other site 271848002855 homodimer interface [polypeptide binding]; other site 271848002856 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848002857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002858 putative substrate translocation pore; other site 271848002859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002860 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 271848002861 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 271848002862 Ligand binding site; other site 271848002863 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848002864 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 271848002865 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848002866 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848002867 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848002868 MULE transposase domain; Region: MULE; pfam10551 271848002869 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 271848002870 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848002871 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271848002872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848002873 dimerization interface [polypeptide binding]; other site 271848002874 putative DNA binding site [nucleotide binding]; other site 271848002875 putative Zn2+ binding site [ion binding]; other site 271848002876 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 271848002877 Predicted transporter component [General function prediction only]; Region: COG2391 271848002878 Sulphur transport; Region: Sulf_transp; cl01018 271848002879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 271848002880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848002881 Coenzyme A binding pocket [chemical binding]; other site 271848002882 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 271848002883 Leucine carboxyl methyltransferase; Region: LCM; cl01306 271848002884 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 271848002885 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848002886 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848002887 active site 271848002888 metal binding site [ion binding]; metal-binding site 271848002889 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848002890 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848002891 active site 271848002892 benzoate transport; Region: 2A0115; TIGR00895 271848002893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002894 putative substrate translocation pore; other site 271848002895 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 271848002896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848002897 DNA-binding site [nucleotide binding]; DNA binding site 271848002898 UTRA domain; Region: UTRA; cl01230 271848002899 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 271848002900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002901 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 271848002902 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848002903 LabA_like proteins; Region: LabA_like; cd06167 271848002904 putative metal binding site [ion binding]; other site 271848002905 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 271848002906 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 271848002907 Helix-turn-helix domains; Region: HTH; cl00088 271848002908 AsnC family; Region: AsnC_trans_reg; pfam01037 271848002909 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 271848002910 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 271848002911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848002912 catalytic residue [active] 271848002913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848002914 Phosphoesterase family; Region: Phosphoesterase; cl15450 271848002915 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848002916 BCCT family transporter; Region: BCCT; cl00569 271848002917 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848002918 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848002919 putative active site [active] 271848002920 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 271848002921 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 271848002922 catalytic nucleophile [active] 271848002923 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 271848002924 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848002925 Walker A/P-loop; other site 271848002926 ATP binding site [chemical binding]; other site 271848002927 Q-loop/lid; other site 271848002928 ABC transporter signature motif; other site 271848002929 Walker B; other site 271848002930 D-loop; other site 271848002931 H-loop/switch region; other site 271848002932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848002933 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 271848002934 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848002935 Walker A/P-loop; other site 271848002936 ATP binding site [chemical binding]; other site 271848002937 Q-loop/lid; other site 271848002938 ABC transporter signature motif; other site 271848002939 Walker B; other site 271848002940 D-loop; other site 271848002941 H-loop/switch region; other site 271848002942 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848002943 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 271848002944 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 271848002945 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 271848002946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848002947 dimer interface [polypeptide binding]; other site 271848002948 conserved gate region; other site 271848002949 putative PBP binding loops; other site 271848002950 ABC-ATPase subunit interface; other site 271848002951 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 271848002952 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 271848002953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848002954 dimer interface [polypeptide binding]; other site 271848002955 conserved gate region; other site 271848002956 putative PBP binding loops; other site 271848002957 ABC-ATPase subunit interface; other site 271848002958 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 271848002959 homotetramer interface [polypeptide binding]; other site 271848002960 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 271848002961 cleavage site 271848002962 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 271848002963 SxDxEG motif; other site 271848002964 active site 271848002965 metal binding site [ion binding]; metal-binding site 271848002966 homopentamer interface [polypeptide binding]; other site 271848002967 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 271848002968 active site 271848002969 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 271848002970 heterodimer interface [polypeptide binding]; other site 271848002971 multimer interface [polypeptide binding]; other site 271848002972 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 271848002973 active site 271848002974 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 271848002975 Helix-turn-helix domains; Region: HTH; cl00088 271848002976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848002977 dimerization interface [polypeptide binding]; other site 271848002978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848002979 metal binding site [ion binding]; metal-binding site 271848002980 active site 271848002981 I-site; other site 271848002982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848002983 NeuB family; Region: NeuB; cl00496 271848002984 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271848002985 YCII-related domain; Region: YCII; cl00999 271848002986 Cache domain; Region: Cache_1; pfam02743 271848002987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848002988 metal binding site [ion binding]; metal-binding site 271848002989 active site 271848002990 I-site; other site 271848002991 putative transporter; Provisional; Region: PRK11021 271848002992 ATP-dependent helicase; Provisional; Region: PRK13767 271848002993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848002994 ATP binding site [chemical binding]; other site 271848002995 putative Mg++ binding site [ion binding]; other site 271848002996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848002997 nucleotide binding region [chemical binding]; other site 271848002998 ATP-binding site [chemical binding]; other site 271848002999 DEAD/H associated; Region: DEAD_assoc; pfam08494 271848003000 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 271848003001 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 271848003002 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 271848003003 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 271848003004 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 271848003005 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 271848003006 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 271848003007 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39C; cd02419 271848003008 putative active site [active] 271848003009 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271848003010 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 271848003011 Walker A/P-loop; other site 271848003012 ATP binding site [chemical binding]; other site 271848003013 Q-loop/lid; other site 271848003014 ABC transporter signature motif; other site 271848003015 Walker B; other site 271848003016 D-loop; other site 271848003017 H-loop/switch region; other site 271848003018 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848003019 putative acyl-acceptor binding pocket; other site 271848003020 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 271848003021 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848003022 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 271848003023 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 271848003024 threonine dehydratase; Reviewed; Region: PRK09224 271848003025 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271848003026 tetramer interface [polypeptide binding]; other site 271848003027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848003028 catalytic residue [active] 271848003029 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 271848003030 putative Ile/Val binding site [chemical binding]; other site 271848003031 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 271848003032 putative Ile/Val binding site [chemical binding]; other site 271848003033 EamA-like transporter family; Region: EamA; cl01037 271848003034 Uncharacterized conserved protein [Function unknown]; Region: COG1739 271848003035 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 271848003036 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 271848003037 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 271848003038 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 271848003039 hypothetical protein; Provisional; Region: PRK09040 271848003040 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848003041 ligand binding site [chemical binding]; other site 271848003042 Domain of unknown function (DUF802); Region: DUF802; pfam05650 271848003043 Domain of unknown function (DUF802); Region: DUF802; pfam05650 271848003044 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 271848003045 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; cl01820 271848003046 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848003047 short chain dehydrogenase; Provisional; Region: PRK12937 271848003048 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 271848003049 NADP binding site [chemical binding]; other site 271848003050 homodimer interface [polypeptide binding]; other site 271848003051 active site 271848003052 substrate binding site [chemical binding]; other site 271848003053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848003054 Helix-turn-helix domains; Region: HTH; cl00088 271848003055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848003056 dimerization interface [polypeptide binding]; other site 271848003057 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 271848003058 Helix-turn-helix domains; Region: HTH; cl00088 271848003059 transcriptional activator TtdR; Provisional; Region: PRK09801 271848003060 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848003061 putative effector binding pocket; other site 271848003062 dimerization interface [polypeptide binding]; other site 271848003063 NMT1-like family; Region: NMT1_2; cl15260 271848003064 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 271848003065 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 271848003066 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 271848003067 putative NAD(P) binding site [chemical binding]; other site 271848003068 dimer interface [polypeptide binding]; other site 271848003069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848003070 Helix-turn-helix domains; Region: HTH; cl00088 271848003071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848003072 dimerization interface [polypeptide binding]; other site 271848003073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003074 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848003075 putative substrate translocation pore; other site 271848003076 allantoate amidohydrolase; Reviewed; Region: PRK12893 271848003077 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 271848003078 active site 271848003079 metal binding site [ion binding]; metal-binding site 271848003080 dimer interface [polypeptide binding]; other site 271848003081 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 271848003082 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 271848003083 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 271848003084 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 271848003085 NMT1-like family; Region: NMT1_2; cl15260 271848003086 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 271848003087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003088 active site 271848003089 phosphorylation site [posttranslational modification] 271848003090 intermolecular recognition site; other site 271848003091 dimerization interface [polypeptide binding]; other site 271848003092 ANTAR domain; Region: ANTAR; cl04297 271848003093 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271848003094 nitrate transmembrane transporter; Provisional; Region: PLN00028 271848003095 nitrite reductase subunit NirD; Provisional; Region: PRK14989 271848003096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848003097 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271848003098 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848003099 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 271848003100 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 271848003101 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 271848003102 [4Fe-4S] binding site [ion binding]; other site 271848003103 molybdopterin cofactor binding site; other site 271848003104 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 271848003105 molybdopterin cofactor binding site; other site 271848003106 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 271848003107 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271848003108 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 271848003109 FAD binding pocket [chemical binding]; other site 271848003110 FAD binding motif [chemical binding]; other site 271848003111 catalytic residues [active] 271848003112 NAD binding pocket [chemical binding]; other site 271848003113 phosphate binding motif [ion binding]; other site 271848003114 beta-alpha-beta structure motif; other site 271848003115 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 271848003116 N- and C-terminal domain interface [polypeptide binding]; other site 271848003117 active site 271848003118 catalytic site [active] 271848003119 metal binding site [ion binding]; metal-binding site 271848003120 xylulose binding site [chemical binding]; other site 271848003121 putative ATP binding site [chemical binding]; other site 271848003122 homodimer interface [polypeptide binding]; other site 271848003123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848003124 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848003125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848003126 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 271848003127 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 271848003128 Walker A/P-loop; other site 271848003129 ATP binding site [chemical binding]; other site 271848003130 Q-loop/lid; other site 271848003131 ABC transporter signature motif; other site 271848003132 Walker B; other site 271848003133 D-loop; other site 271848003134 H-loop/switch region; other site 271848003135 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 271848003136 L-idonate 5-dehydrogenase; Region: PLN02702 271848003137 inhibitor binding site; inhibition site 271848003138 catalytic Zn binding site [ion binding]; other site 271848003139 structural Zn binding site [ion binding]; other site 271848003140 NADP binding site [chemical binding]; other site 271848003141 tetramer interface [polypeptide binding]; other site 271848003142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003143 dimer interface [polypeptide binding]; other site 271848003144 conserved gate region; other site 271848003145 putative PBP binding loops; other site 271848003146 ABC-ATPase subunit interface; other site 271848003147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848003148 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 271848003149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848003150 Electron transfer DM13; Region: DM13; cl02735 271848003151 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 271848003152 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 271848003153 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271848003154 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 271848003155 active site 271848003156 LssY C-terminus; Region: LssY_C; pfam14067 271848003157 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 271848003158 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848003159 Outer membrane efflux protein; Region: OEP; pfam02321 271848003160 Outer membrane efflux protein; Region: OEP; pfam02321 271848003161 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848003162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848003163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848003164 dimer interface [polypeptide binding]; other site 271848003165 phosphorylation site [posttranslational modification] 271848003166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848003167 ATP binding site [chemical binding]; other site 271848003168 Mg2+ binding site [ion binding]; other site 271848003169 G-X-G motif; other site 271848003170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848003171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003172 active site 271848003173 phosphorylation site [posttranslational modification] 271848003174 intermolecular recognition site; other site 271848003175 dimerization interface [polypeptide binding]; other site 271848003176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848003177 DNA binding site [nucleotide binding] 271848003178 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 271848003179 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 271848003180 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848003181 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848003182 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271848003183 putative cation:proton antiport protein; Provisional; Region: PRK10669 271848003184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003186 NAD(P) binding site [chemical binding]; other site 271848003187 active site 271848003188 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 271848003189 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 271848003190 ligand binding site [chemical binding]; other site 271848003191 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 271848003192 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 271848003193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848003194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 271848003195 Cache domain; Region: Cache_2; cl07034 271848003196 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848003197 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848003198 dimer interface [polypeptide binding]; other site 271848003199 putative CheW interface [polypeptide binding]; other site 271848003200 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 271848003201 Isochorismatase family; Region: Isochorismatase; pfam00857 271848003202 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 271848003203 catalytic triad [active] 271848003204 conserved cis-peptide bond; other site 271848003205 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848003206 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 271848003207 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271848003208 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 271848003209 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848003210 N-terminal plug; other site 271848003211 ligand-binding site [chemical binding]; other site 271848003212 aspartate carbamoyltransferase; Provisional; Region: PRK11891 271848003213 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271848003214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003215 Entericidin EcnA/B family; Region: Entericidin; cl02322 271848003216 Cupin domain; Region: Cupin_2; cl09118 271848003217 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848003218 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848003219 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848003220 DNA-binding site [nucleotide binding]; DNA binding site 271848003221 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848003222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848003223 homodimer interface [polypeptide binding]; other site 271848003224 catalytic residue [active] 271848003225 major capsid protein; Region: PHA00665 271848003226 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848003227 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848003228 active site 271848003229 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848003230 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848003231 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003232 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 271848003233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848003234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848003235 catalytic residue [active] 271848003236 peptide synthase; Provisional; Region: PRK12467 271848003237 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003238 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003239 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003240 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 271848003241 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848003242 Condensation domain; Region: Condensation; pfam00668 271848003243 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848003244 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003245 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003246 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003247 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 271848003248 peptide synthase; Provisional; Region: PRK12316 271848003249 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003250 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003251 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003252 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 271848003253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848003254 catalytic residue [active] 271848003255 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 271848003256 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 271848003257 acyl-CoA synthetase; Validated; Region: PRK05850 271848003258 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003259 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003260 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 271848003261 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848003262 shikimate transporter; Provisional; Region: PRK09952 271848003263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003264 putative substrate translocation pore; other site 271848003265 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 271848003266 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 271848003267 dimer interface [polypeptide binding]; other site 271848003268 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 271848003269 active site 271848003270 Fe binding site [ion binding]; other site 271848003271 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848003272 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003273 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848003274 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003275 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848003276 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271848003277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848003278 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848003279 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848003280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848003281 DNA binding residues [nucleotide binding] 271848003282 dimerization interface [polypeptide binding]; other site 271848003283 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 271848003284 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 271848003285 active site 271848003286 Zn binding site [ion binding]; other site 271848003287 peptide synthase; Provisional; Region: PRK12467 271848003288 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003289 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003290 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003291 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003292 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848003293 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848003294 active site 271848003295 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848003296 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848003297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003298 NAD(P) binding site [chemical binding]; other site 271848003299 active site 271848003300 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003301 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848003302 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848003303 active site 271848003304 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848003305 putative NADP binding site [chemical binding]; other site 271848003306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003307 NAD(P) binding site [chemical binding]; other site 271848003308 active site 271848003309 active site 271848003310 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003311 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 271848003312 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003313 peptide synthase; Validated; Region: PRK05691 271848003314 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003315 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003316 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003317 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848003318 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848003319 active site 271848003320 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 271848003321 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848003322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848003323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848003324 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848003325 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 271848003326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003327 putative substrate translocation pore; other site 271848003328 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 271848003329 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848003330 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 271848003331 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 271848003332 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 271848003333 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848003334 ligand binding site [chemical binding]; other site 271848003335 flexible hinge region; other site 271848003336 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271848003337 putative switch regulator; other site 271848003338 non-specific DNA interactions [nucleotide binding]; other site 271848003339 DNA binding site [nucleotide binding] 271848003340 sequence specific DNA binding site [nucleotide binding]; other site 271848003341 putative cAMP binding site [chemical binding]; other site 271848003342 Response regulator receiver domain; Region: Response_reg; pfam00072 271848003343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003344 active site 271848003345 phosphorylation site [posttranslational modification] 271848003346 intermolecular recognition site; other site 271848003347 dimerization interface [polypeptide binding]; other site 271848003348 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848003349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003350 active site 271848003351 phosphorylation site [posttranslational modification] 271848003352 intermolecular recognition site; other site 271848003353 dimerization interface [polypeptide binding]; other site 271848003354 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848003355 DNA binding residues [nucleotide binding] 271848003356 dimerization interface [polypeptide binding]; other site 271848003357 CHASE domain; Region: CHASE; cl01369 271848003358 PAS domain S-box; Region: sensory_box; TIGR00229 271848003359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848003360 putative active site [active] 271848003361 heme pocket [chemical binding]; other site 271848003362 Histidine kinase; Region: HisKA_3; pfam07730 271848003363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848003364 ATP binding site [chemical binding]; other site 271848003365 Mg2+ binding site [ion binding]; other site 271848003366 G-X-G motif; other site 271848003367 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 271848003368 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 271848003369 [4Fe-4S] binding site [ion binding]; other site 271848003370 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848003371 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848003372 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848003373 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 271848003374 molybdopterin cofactor binding site; other site 271848003375 nitrate reductase, beta subunit; Region: narH; TIGR01660 271848003376 4Fe-4S binding domain; Region: Fer4; cl02805 271848003377 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 271848003378 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 271848003379 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271848003380 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 271848003381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003382 putative substrate translocation pore; other site 271848003383 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 271848003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848003385 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 271848003386 regulatory phosphorylation site [posttranslational modification]; other site 271848003387 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 271848003388 hydrogenase 4 subunit B; Validated; Region: PRK06521 271848003389 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 271848003390 NADH dehydrogenase; Region: NADHdh; cl00469 271848003391 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 271848003392 hydrogenase 4 subunit F; Validated; Region: PRK06458 271848003393 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 271848003394 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 271848003395 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 271848003396 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 271848003397 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848003398 Ligand Binding Site [chemical binding]; other site 271848003399 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848003400 Ligand Binding Site [chemical binding]; other site 271848003401 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 271848003402 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 271848003403 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 271848003404 ATP binding site [chemical binding]; other site 271848003405 Helix-turn-helix domains; Region: HTH; cl00088 271848003406 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 271848003407 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 271848003408 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 271848003409 active site 271848003410 FMN binding site [chemical binding]; other site 271848003411 2,4-decadienoyl-CoA binding site; other site 271848003412 catalytic residue [active] 271848003413 4Fe-4S cluster binding site [ion binding]; other site 271848003414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003415 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848003416 PAS fold; Region: PAS_4; pfam08448 271848003417 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 271848003418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848003419 DNA binding residues [nucleotide binding] 271848003420 dimerization interface [polypeptide binding]; other site 271848003421 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 271848003422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003423 putative substrate translocation pore; other site 271848003424 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848003425 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848003426 active site 271848003427 metal binding site [ion binding]; metal-binding site 271848003428 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 271848003429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003430 S-adenosylmethionine binding site [chemical binding]; other site 271848003431 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 271848003432 catalytic motif [active] 271848003433 Zn binding site [ion binding]; other site 271848003434 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 271848003435 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 271848003436 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271848003437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003438 S-adenosylmethionine binding site [chemical binding]; other site 271848003439 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 271848003440 structural tetrad; other site 271848003441 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 271848003442 structural tetrad; other site 271848003443 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 271848003444 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 271848003445 dimerization interface [polypeptide binding]; other site 271848003446 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 271848003447 active site 271848003448 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 271848003449 multidrug efflux protein; Reviewed; Region: PRK09579 271848003450 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848003451 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848003452 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848003453 Predicted transcriptional regulator [Transcription]; Region: COG2345 271848003454 Helix-turn-helix domains; Region: HTH; cl00088 271848003455 Helix-turn-helix domains; Region: HTH; cl00088 271848003456 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 271848003457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848003458 active site 271848003459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848003460 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 271848003461 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848003462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848003463 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 271848003464 Walker A/P-loop; other site 271848003465 ATP binding site [chemical binding]; other site 271848003466 Q-loop/lid; other site 271848003467 ABC transporter signature motif; other site 271848003468 Walker B; other site 271848003469 D-loop; other site 271848003470 H-loop/switch region; other site 271848003471 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848003472 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 271848003473 Walker A/P-loop; other site 271848003474 ATP binding site [chemical binding]; other site 271848003475 Q-loop/lid; other site 271848003476 ABC transporter signature motif; other site 271848003477 Walker B; other site 271848003478 D-loop; other site 271848003479 H-loop/switch region; other site 271848003480 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 271848003481 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848003482 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848003483 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 271848003484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848003485 Walker A motif; other site 271848003486 ATP binding site [chemical binding]; other site 271848003487 Walker B motif; other site 271848003488 arginine finger; other site 271848003489 Peptidase family M41; Region: Peptidase_M41; pfam01434 271848003490 Rhomboid family; Region: Rhomboid; cl11446 271848003491 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 271848003492 nudix motif; other site 271848003493 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 271848003494 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 271848003495 dimerization interface [polypeptide binding]; other site 271848003496 active site 271848003497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003498 S-adenosylmethionine binding site [chemical binding]; other site 271848003499 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 271848003500 dimer interface [polypeptide binding]; other site 271848003501 substrate binding site [chemical binding]; other site 271848003502 ATP binding site [chemical binding]; other site 271848003503 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 271848003504 Mannan-binding protein; Region: MVL; pfam12151 271848003505 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271848003506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848003507 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 271848003508 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 271848003509 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848003510 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 271848003511 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848003512 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 271848003513 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 271848003514 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848003515 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848003516 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 271848003517 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 271848003518 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 271848003519 hypothetical protein; Reviewed; Region: PRK09588 271848003520 GYD domain; Region: GYD; cl01743 271848003521 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 271848003522 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 271848003523 putative active site [active] 271848003524 putative metal binding site [ion binding]; other site 271848003525 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 271848003526 DNA-K related protein; Region: DUF3731; pfam12531 271848003527 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 271848003528 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 271848003529 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848003530 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 271848003531 putative kissing complex interaction region; other site 271848003532 putative RNA binding sites [nucleotide binding]; other site 271848003533 H-NS histone family; Region: Histone_HNS; pfam00816 271848003534 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848003535 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848003536 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 271848003537 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271848003538 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 271848003539 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 271848003540 Phage tail tube protein FII; Region: Phage_tube; cl01390 271848003541 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 271848003542 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 271848003543 long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584 271848003544 Phage Tail Collar Domain; Region: Collar; pfam07484 271848003545 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 271848003546 Baseplate J-like protein; Region: Baseplate_J; cl01294 271848003547 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848003548 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 271848003549 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848003550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848003551 hypothetical protein; Region: PHA02416 271848003552 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 271848003553 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 271848003554 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 271848003555 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 271848003556 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 271848003557 Protein of unknown function (DUF754); Region: DUF754; pfam05449 271848003558 Phage Tail Protein X; Region: Phage_tail_X; cl02088 271848003559 hypothetical protein; Region: PHA02417 271848003560 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 271848003561 terminase endonuclease subunit; Provisional; Region: M; PHA02537 271848003562 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 271848003563 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 271848003564 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 271848003565 terminase ATPase subunit; Provisional; Region: P; PHA02535 271848003566 Helix-turn-helix domains; Region: HTH; cl00088 271848003567 Phage Terminase; Region: Terminase_1; pfam03354 271848003568 Phage-related protein [Function unknown]; Region: COG4695; cl01923 271848003569 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 271848003570 Protein of unknown function (DUF497); Region: DUF497; cl01108 271848003571 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 271848003572 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 271848003573 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 271848003574 PAAR motif; Region: PAAR_motif; cl15808 271848003575 ParA-like protein; Provisional; Region: PHA02518 271848003576 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848003577 P-loop; other site 271848003578 Magnesium ion binding site [ion binding]; other site 271848003579 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 271848003580 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 271848003581 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276 271848003582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848003583 cofactor binding site; other site 271848003584 DNA binding site [nucleotide binding] 271848003585 substrate interaction site [chemical binding]; other site 271848003586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848003587 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848003588 Active Sites [active] 271848003589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848003590 Phage related protein; Region: DUF3693; pfam12472 271848003591 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 271848003592 putative deacylase active site [active] 271848003593 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 271848003594 catalytic residue [active] 271848003595 Adenosine specific kinase; Region: Adenosine_kin; cl00796 271848003596 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 271848003597 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848003598 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 271848003599 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848003600 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 271848003601 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 271848003602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003603 active site 271848003604 phosphorylation site [posttranslational modification] 271848003605 intermolecular recognition site; other site 271848003606 dimerization interface [polypeptide binding]; other site 271848003607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848003608 DNA binding site [nucleotide binding] 271848003609 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 271848003610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848003611 dimerization interface [polypeptide binding]; other site 271848003612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848003613 dimer interface [polypeptide binding]; other site 271848003614 phosphorylation site [posttranslational modification] 271848003615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848003616 ATP binding site [chemical binding]; other site 271848003617 Mg2+ binding site [ion binding]; other site 271848003618 G-X-G motif; other site 271848003619 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848003620 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 271848003621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848003622 active site 271848003623 Phospholipid methyltransferase; Region: PEMT; cl00763 271848003624 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 271848003625 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848003626 N-terminal plug; other site 271848003627 ligand-binding site [chemical binding]; other site 271848003628 fec operon regulator FecR; Reviewed; Region: PRK09774 271848003629 FecR protein; Region: FecR; pfam04773 271848003630 RNA polymerase sigma factor; Provisional; Region: PRK12528 271848003631 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848003632 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848003633 DNA binding residues [nucleotide binding] 271848003634 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 271848003635 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 271848003636 YceI-like domain; Region: YceI; cl01001 271848003637 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 271848003638 RNA polymerase sigma factor; Provisional; Region: PRK12511 271848003639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848003640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848003641 DNA binding residues [nucleotide binding] 271848003642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848003643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848003644 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848003645 CAAX protease self-immunity; Region: Abi; cl00558 271848003646 MarC family integral membrane protein; Region: MarC; cl00919 271848003647 AMP-binding enzyme; Region: AMP-binding; cl15778 271848003648 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 271848003649 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 271848003650 transcriptional regulator; Provisional; Region: PRK10632 271848003651 Helix-turn-helix domains; Region: HTH; cl00088 271848003652 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848003653 putative effector binding pocket; other site 271848003654 dimerization interface [polypeptide binding]; other site 271848003655 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 271848003656 HPP family; Region: HPP; pfam04982 271848003657 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 271848003658 Helix-turn-helix domains; Region: HTH; cl00088 271848003659 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 271848003660 Cl- selectivity filter; other site 271848003661 Cl- binding residues [ion binding]; other site 271848003662 pore gating glutamate residue; other site 271848003663 FOG: CBS domain [General function prediction only]; Region: COG0517 271848003664 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 271848003665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003666 S-adenosylmethionine binding site [chemical binding]; other site 271848003667 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 271848003668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848003669 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 271848003670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003671 active site 271848003672 phosphorylation site [posttranslational modification] 271848003673 intermolecular recognition site; other site 271848003674 dimerization interface [polypeptide binding]; other site 271848003675 LytTr DNA-binding domain; Region: LytTR; cl04498 271848003676 Histidine kinase; Region: His_kinase; pfam06580 271848003677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 271848003678 Integrase core domain; Region: rve_3; cl15866 271848003679 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 271848003680 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 271848003681 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 271848003682 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 271848003683 putative active site [active] 271848003684 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 271848003685 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 271848003686 Walker A/P-loop; other site 271848003687 ATP binding site [chemical binding]; other site 271848003688 Q-loop/lid; other site 271848003689 ABC transporter signature motif; other site 271848003690 Walker B; other site 271848003691 D-loop; other site 271848003692 H-loop/switch region; other site 271848003693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003694 dimer interface [polypeptide binding]; other site 271848003695 conserved gate region; other site 271848003696 putative PBP binding loops; other site 271848003697 ABC-ATPase subunit interface; other site 271848003698 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848003699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003700 dimer interface [polypeptide binding]; other site 271848003701 conserved gate region; other site 271848003702 putative PBP binding loops; other site 271848003703 ABC-ATPase subunit interface; other site 271848003704 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 271848003705 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848003706 trimer interface [polypeptide binding]; other site 271848003707 eyelet of channel; other site 271848003708 DoxX; Region: DoxX; cl00976 271848003709 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848003710 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848003711 Cytochrome c; Region: Cytochrom_C; cl11414 271848003712 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 271848003713 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848003714 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 271848003715 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 271848003716 active site 271848003717 catalytic triad [active] 271848003718 magnesium-transporting ATPase; Provisional; Region: PRK15122 271848003719 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 271848003720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848003721 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 271848003722 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848003723 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848003724 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 271848003725 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 271848003726 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848003727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848003728 DNA-binding site [nucleotide binding]; DNA binding site 271848003729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848003730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848003731 homodimer interface [polypeptide binding]; other site 271848003732 catalytic residue [active] 271848003733 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 271848003734 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 271848003735 putative molybdopterin cofactor binding site [chemical binding]; other site 271848003736 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 271848003737 putative molybdopterin cofactor binding site; other site 271848003738 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 271848003739 yiaA/B two helix domain; Region: YiaAB; cl01759 271848003740 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 271848003741 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 271848003742 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 271848003743 Cupin domain; Region: Cupin_2; cl09118 271848003744 Cupin domain; Region: Cupin_2; cl09118 271848003745 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 271848003746 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 271848003747 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848003748 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 271848003749 catalytic triad [active] 271848003750 putative active site [active] 271848003751 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 271848003752 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 271848003753 PAAR motif; Region: PAAR_motif; cl15808 271848003754 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848003755 RHS Repeat; Region: RHS_repeat; cl11982 271848003756 RHS Repeat; Region: RHS_repeat; cl11982 271848003757 RHS Repeat; Region: RHS_repeat; cl11982 271848003758 RHS Repeat; Region: RHS_repeat; cl11982 271848003759 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848003760 RHS Repeat; Region: RHS_repeat; cl11982 271848003761 RHS Repeat; Region: RHS_repeat; cl11982 271848003762 RHS Repeat; Region: RHS_repeat; cl11982 271848003763 RHS Repeat; Region: RHS_repeat; cl11982 271848003764 RHS Repeat; Region: RHS_repeat; cl11982 271848003765 RHS Repeat; Region: RHS_repeat; cl11982 271848003766 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 271848003767 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 271848003768 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848003769 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848003770 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848003771 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 271848003772 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848003773 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848003774 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848003775 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 271848003776 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 271848003777 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 271848003778 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 271848003779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003780 dimer interface [polypeptide binding]; other site 271848003781 conserved gate region; other site 271848003782 putative PBP binding loops; other site 271848003783 ABC-ATPase subunit interface; other site 271848003784 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 271848003785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003786 dimer interface [polypeptide binding]; other site 271848003787 conserved gate region; other site 271848003788 putative PBP binding loops; other site 271848003789 ABC-ATPase subunit interface; other site 271848003790 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 271848003791 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848003792 Walker A/P-loop; other site 271848003793 ATP binding site [chemical binding]; other site 271848003794 Q-loop/lid; other site 271848003795 ABC transporter signature motif; other site 271848003796 Walker B; other site 271848003797 D-loop; other site 271848003798 H-loop/switch region; other site 271848003799 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 271848003800 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848003801 Walker A/P-loop; other site 271848003802 ATP binding site [chemical binding]; other site 271848003803 Q-loop/lid; other site 271848003804 ABC transporter signature motif; other site 271848003805 Walker B; other site 271848003806 D-loop; other site 271848003807 H-loop/switch region; other site 271848003808 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848003809 Helix-turn-helix domains; Region: HTH; cl00088 271848003810 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848003811 substrate binding pocket [chemical binding]; other site 271848003812 dimerization interface [polypeptide binding]; other site 271848003813 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848003814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848003815 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 271848003816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848003817 Helix-turn-helix domains; Region: HTH; cl00088 271848003818 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 271848003819 putative dimerization interface [polypeptide binding]; other site 271848003820 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848003821 trimer interface [polypeptide binding]; other site 271848003822 eyelet of channel; other site 271848003823 OpgC protein; Region: OpgC_C; cl00792 271848003824 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848003825 Putative esterase; Region: Esterase; pfam00756 271848003826 ornithine cyclodeaminase; Validated; Region: PRK07340 271848003827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003828 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848003829 short chain dehydrogenase; Validated; Region: PRK05855 271848003830 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 271848003831 Ion channel; Region: Ion_trans_2; cl11596 271848003832 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 271848003833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003834 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848003835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003837 BetR domain; Region: BetR; pfam08667 271848003838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003839 active site 271848003840 phosphorylation site [posttranslational modification] 271848003841 intermolecular recognition site; other site 271848003842 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 271848003843 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848003844 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 271848003845 Family description; Region: UvrD_C_2; cl15862 271848003846 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 271848003847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848003848 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848003849 dimer interface [polypeptide binding]; other site 271848003850 putative CheW interface [polypeptide binding]; other site 271848003851 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848003852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003853 putative substrate translocation pore; other site 271848003854 hypothetical protein; Provisional; Region: PRK12495 271848003855 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 271848003856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848003857 Coenzyme A binding pocket [chemical binding]; other site 271848003858 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 271848003859 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271848003860 DNA binding residues [nucleotide binding] 271848003861 putative dimer interface [polypeptide binding]; other site 271848003862 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 271848003863 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848003864 substrate binding pocket [chemical binding]; other site 271848003865 membrane-bound complex binding site; other site 271848003866 hinge residues; other site 271848003867 YhhN-like protein; Region: YhhN; cl01505 271848003868 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 271848003869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003870 short chain dehydrogenase; Provisional; Region: PRK07832 271848003871 classical (c) SDRs; Region: SDR_c; cd05233 271848003872 NAD(P) binding site [chemical binding]; other site 271848003873 active site 271848003874 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848003875 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848003876 short chain dehydrogenase; Validated; Region: PRK05855 271848003877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848003878 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848003879 Helix-turn-helix domains; Region: HTH; cl00088 271848003880 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848003881 putative effector binding pocket; other site 271848003882 dimerization interface [polypeptide binding]; other site 271848003883 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271848003884 Amidase; Region: Amidase; cl11426 271848003885 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 271848003886 Helix-turn-helix domains; Region: HTH; cl00088 271848003887 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 271848003888 N-acetyltransferase; Region: Acetyltransf_2; cl00949 271848003889 methionine gamma-lyase; Validated; Region: PRK07049 271848003890 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 271848003891 homodimer interface [polypeptide binding]; other site 271848003892 substrate-cofactor binding pocket; other site 271848003893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848003894 catalytic residue [active] 271848003895 Helix-turn-helix domains; Region: HTH; cl00088 271848003896 AsnC family; Region: AsnC_trans_reg; pfam01037 271848003897 amidase; Provisional; Region: PRK07486 271848003898 Amidase; Region: Amidase; cl11426 271848003899 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848003900 Ligand Binding Site [chemical binding]; other site 271848003901 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 271848003902 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848003903 ligand binding site [chemical binding]; other site 271848003904 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 271848003905 Haemagglutinin; Region: HIM; pfam05662 271848003906 Haemagglutinin; Region: HIM; pfam05662 271848003907 Haemagglutinin; Region: HIM; pfam05662 271848003908 YadA-like C-terminal region; Region: YadA; pfam03895 271848003909 benzoate transport; Region: 2A0115; TIGR00895 271848003910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003911 putative substrate translocation pore; other site 271848003912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003913 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 271848003914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848003915 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 271848003916 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848003917 active site 271848003918 metal binding site [ion binding]; metal-binding site 271848003919 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 271848003920 putative active site [active] 271848003921 putative metal binding site [ion binding]; other site 271848003922 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848003923 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 271848003924 NAD(P) binding site [chemical binding]; other site 271848003925 catalytic residues [active] 271848003926 L-aspartate dehydrogenase; Provisional; Region: PRK13303 271848003927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003928 Domain of unknown function DUF108; Region: DUF108; pfam01958 271848003929 hypothetical protein; Provisional; Region: PRK07064 271848003930 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848003931 PYR/PP interface [polypeptide binding]; other site 271848003932 dimer interface [polypeptide binding]; other site 271848003933 TPP binding site [chemical binding]; other site 271848003934 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271848003935 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 271848003936 TPP-binding site [chemical binding]; other site 271848003937 short chain dehydrogenase; Provisional; Region: PRK07062 271848003938 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 271848003939 putative NAD(P) binding site [chemical binding]; other site 271848003940 putative active site [active] 271848003941 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848003942 Helix-turn-helix domains; Region: HTH; cl00088 271848003943 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848003944 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848003945 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848003946 Cupin domain; Region: Cupin_2; cl09118 271848003947 short chain dehydrogenase; Provisional; Region: PRK12939 271848003948 classical (c) SDRs; Region: SDR_c; cd05233 271848003949 NAD(P) binding site [chemical binding]; other site 271848003950 active site 271848003951 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848003952 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 271848003953 iron-sulfur cluster [ion binding]; other site 271848003954 [2Fe-2S] cluster binding site [ion binding]; other site 271848003955 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 271848003956 hydrophobic ligand binding site; other site 271848003957 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 271848003958 [2Fe-2S] cluster binding site [ion binding]; other site 271848003959 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848003960 trimer interface [polypeptide binding]; other site 271848003961 eyelet of channel; other site 271848003962 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848003963 Helix-turn-helix domains; Region: HTH; cl00088 271848003964 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848003965 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848003966 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 271848003967 putative FMN binding site [chemical binding]; other site 271848003968 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 271848003969 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848003970 putative active site [active] 271848003971 putative metal binding site [ion binding]; other site 271848003972 magnesium transport protein MgtC; Provisional; Region: PRK15385 271848003973 MgtC family; Region: MgtC; pfam02308 271848003974 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848003975 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848003976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848003977 DNA binding residues [nucleotide binding] 271848003978 dimerization interface [polypeptide binding]; other site 271848003979 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848003980 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 271848003981 NADH/NADPH cofactor binding site [chemical binding]; other site 271848003982 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 271848003983 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 271848003984 dimerization interface [polypeptide binding]; other site 271848003985 active site 271848003986 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 271848003987 FOG: CBS domain [General function prediction only]; Region: COG0517 271848003988 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848003989 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 271848003990 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 271848003991 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848003992 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848003993 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848003994 trimer interface [polypeptide binding]; other site 271848003995 eyelet of channel; other site 271848003996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848003997 putative DNA binding site [nucleotide binding]; other site 271848003998 dimerization interface [polypeptide binding]; other site 271848003999 putative Zn2+ binding site [ion binding]; other site 271848004000 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 271848004001 FMN binding site [chemical binding]; other site 271848004002 active site 271848004003 substrate binding site [chemical binding]; other site 271848004004 catalytic residue [active] 271848004005 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848004006 LysE type translocator; Region: LysE; cl00565 271848004007 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848004008 MULE transposase domain; Region: MULE; pfam10551 271848004009 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 271848004010 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848004011 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848004012 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848004013 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848004014 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848004015 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848004016 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004017 trimer interface [polypeptide binding]; other site 271848004018 eyelet of channel; other site 271848004019 transcriptional regulator EutR; Provisional; Region: PRK10130 271848004020 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 271848004021 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 271848004022 Spore germination protein; Region: Spore_permease; cl15802 271848004023 hypothetical protein; Provisional; Region: PRK07481 271848004024 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848004025 inhibitor-cofactor binding pocket; inhibition site 271848004026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004027 catalytic residue [active] 271848004028 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848004029 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848004030 NAD(P) binding site [chemical binding]; other site 271848004031 catalytic residues [active] 271848004032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848004033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004034 DNA binding residues [nucleotide binding] 271848004035 dimerization interface [polypeptide binding]; other site 271848004036 classical (c) SDRs; Region: SDR_c; cd05233 271848004037 NAD(P) binding site [chemical binding]; other site 271848004038 active site 271848004039 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 271848004040 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 271848004041 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848004042 active site 271848004043 catalytic tetrad [active] 271848004044 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 271848004045 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 271848004046 catalytic residues [active] 271848004047 transcriptional regulator; Provisional; Region: PRK10632 271848004048 Helix-turn-helix domains; Region: HTH; cl00088 271848004049 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848004050 putative effector binding pocket; other site 271848004051 dimerization interface [polypeptide binding]; other site 271848004052 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 271848004053 flagellar capping protein; Reviewed; Region: fliD; PRK08032 271848004054 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 271848004055 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848004056 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848004057 allantoate amidohydrolase; Reviewed; Region: PRK12891 271848004058 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 271848004059 active site 271848004060 metal binding site [ion binding]; metal-binding site 271848004061 dimer interface [polypeptide binding]; other site 271848004062 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 271848004063 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848004064 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848004065 dimerization interface [polypeptide binding]; other site 271848004066 ligand binding site [chemical binding]; other site 271848004067 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848004068 Helix-turn-helix domains; Region: HTH; cl00088 271848004069 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848004070 dimerization interface [polypeptide binding]; other site 271848004071 substrate binding pocket [chemical binding]; other site 271848004072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848004073 DEAD_2; Region: DEAD_2; pfam06733 271848004074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848004075 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 271848004076 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848004077 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 271848004078 substrate binding site [chemical binding]; other site 271848004079 dimer interface [polypeptide binding]; other site 271848004080 ATP binding site [chemical binding]; other site 271848004081 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 271848004082 active site 271848004083 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848004084 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848004085 H-NS histone family; Region: Histone_HNS; pfam00816 271848004086 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848004087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848004088 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 271848004089 Spore germination protein; Region: Spore_permease; cl15802 271848004090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004091 NAD(P) binding site [chemical binding]; other site 271848004092 active site 271848004093 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 271848004094 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848004095 active site residue [active] 271848004096 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 271848004097 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 271848004098 catalytic Zn binding site [ion binding]; other site 271848004099 structural Zn binding site [ion binding]; other site 271848004100 NAD(P) binding site [chemical binding]; other site 271848004101 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 271848004102 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004103 Ligand Binding Site [chemical binding]; other site 271848004104 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004105 Ligand Binding Site [chemical binding]; other site 271848004106 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004107 Ligand Binding Site [chemical binding]; other site 271848004108 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004109 Ligand Binding Site [chemical binding]; other site 271848004110 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004111 Ligand Binding Site [chemical binding]; other site 271848004112 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848004113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004114 active site 271848004115 phosphorylation site [posttranslational modification] 271848004116 intermolecular recognition site; other site 271848004117 dimerization interface [polypeptide binding]; other site 271848004118 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004119 DNA binding residues [nucleotide binding] 271848004120 dimerization interface [polypeptide binding]; other site 271848004121 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 271848004122 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 271848004123 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 271848004124 Cupin domain; Region: Cupin_2; cl09118 271848004125 putative monooxygenase; Reviewed; Region: PRK07045 271848004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004127 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848004128 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 271848004129 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848004130 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848004131 ligand binding site [chemical binding]; other site 271848004132 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 271848004133 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 271848004134 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 271848004135 MG2 domain; Region: A2M_N; pfam01835 271848004136 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 271848004137 Alpha-2-macroglobulin family; Region: A2M; pfam00207 271848004138 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 271848004139 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 271848004140 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 271848004141 Transglycosylase; Region: Transgly; cl07896 271848004142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848004143 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 271848004144 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 271848004145 Response regulator receiver domain; Region: Response_reg; pfam00072 271848004146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004147 active site 271848004148 phosphorylation site [posttranslational modification] 271848004149 intermolecular recognition site; other site 271848004150 dimerization interface [polypeptide binding]; other site 271848004151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848004152 sensory histidine kinase AtoS; Provisional; Region: PRK11360 271848004153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848004154 ATP binding site [chemical binding]; other site 271848004155 G-X-G motif; other site 271848004156 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 271848004157 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 271848004158 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848004159 Protein of unknown function, DUF488; Region: DUF488; cl01246 271848004160 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 271848004161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848004162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004163 homodimer interface [polypeptide binding]; other site 271848004164 catalytic residue [active] 271848004165 aromatic amino acid transporter; Provisional; Region: PRK10238 271848004166 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848004167 Helix-turn-helix domains; Region: HTH; cl00088 271848004168 AsnC family; Region: AsnC_trans_reg; pfam01037 271848004169 Haemolysin-III related; Region: HlyIII; cl03831 271848004170 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848004171 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848004172 dimerization interface [polypeptide binding]; other site 271848004173 ligand binding site [chemical binding]; other site 271848004174 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848004175 CoenzymeA binding site [chemical binding]; other site 271848004176 subunit interaction site [polypeptide binding]; other site 271848004177 PHB binding site; other site 271848004178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848004179 Helix-turn-helix domains; Region: HTH; cl00088 271848004180 Domain of unknown function (DUF718); Region: DUF718; cl01281 271848004181 short chain dehydrogenase; Provisional; Region: PRK08628 271848004182 classical (c) SDRs; Region: SDR_c; cd05233 271848004183 NAD(P) binding site [chemical binding]; other site 271848004184 active site 271848004185 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 271848004186 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848004187 short chain dehydrogenase; Provisional; Region: PRK06138 271848004188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004189 NAD(P) binding site [chemical binding]; other site 271848004190 active site 271848004191 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848004192 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848004193 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 271848004194 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 271848004195 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 271848004196 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848004197 TM-ABC transporter signature motif; other site 271848004198 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848004199 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 271848004200 Walker A/P-loop; other site 271848004201 ATP binding site [chemical binding]; other site 271848004202 Q-loop/lid; other site 271848004203 ABC transporter signature motif; other site 271848004204 Walker B; other site 271848004205 D-loop; other site 271848004206 H-loop/switch region; other site 271848004207 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 271848004208 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 271848004209 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848004210 ligand binding site [chemical binding]; other site 271848004211 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848004212 Helix-turn-helix domains; Region: HTH; cl00088 271848004213 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 271848004214 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 271848004215 DNA binding residues [nucleotide binding] 271848004216 dimer interface [polypeptide binding]; other site 271848004217 [2Fe-2S] cluster binding site [ion binding]; other site 271848004218 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848004219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848004220 Helix-turn-helix domains; Region: HTH; cl00088 271848004221 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 271848004222 putative dimerization interface [polypeptide binding]; other site 271848004223 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 271848004224 gating phenylalanine in ion channel; other site 271848004225 malate dehydrogenase; Provisional; Region: PRK05442 271848004226 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 271848004227 NAD(P) binding site [chemical binding]; other site 271848004228 dimer interface [polypeptide binding]; other site 271848004229 malate binding site [chemical binding]; other site 271848004230 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 271848004231 Low-spin heme binding site [chemical binding]; other site 271848004232 D-pathway; other site 271848004233 Putative water exit pathway; other site 271848004234 Binuclear center (active site) [active] 271848004235 K-pathway; other site 271848004236 Putative proton exit pathway; other site 271848004237 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 271848004238 Cytochrome c; Region: Cytochrom_C; cl11414 271848004239 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271848004240 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271848004241 metal-binding site [ion binding] 271848004242 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848004243 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848004244 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 271848004245 Moco binding site; other site 271848004246 metal coordination site [ion binding]; other site 271848004247 Protein of unknown function (DUF419); Region: DUF419; cl15265 271848004248 Cupin domain; Region: Cupin_2; cl09118 271848004249 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 271848004250 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848004251 TM-ABC transporter signature motif; other site 271848004252 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 271848004253 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 271848004254 Walker A/P-loop; other site 271848004255 ATP binding site [chemical binding]; other site 271848004256 Q-loop/lid; other site 271848004257 ABC transporter signature motif; other site 271848004258 Walker B; other site 271848004259 D-loop; other site 271848004260 H-loop/switch region; other site 271848004261 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 271848004262 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 271848004263 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 271848004264 ligand binding site [chemical binding]; other site 271848004265 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271848004266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004267 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848004268 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 271848004269 inhibitor site; inhibition site 271848004270 active site 271848004271 dimer interface [polypeptide binding]; other site 271848004272 catalytic residue [active] 271848004273 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 271848004274 dimer interface [polypeptide binding]; other site 271848004275 NADP binding site [chemical binding]; other site 271848004276 catalytic residues [active] 271848004277 Dehydratase family; Region: ILVD_EDD; cl00340 271848004278 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 271848004279 Helix-turn-helix domains; Region: HTH; cl00088 271848004280 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 271848004281 putative dimerization interface [polypeptide binding]; other site 271848004282 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848004283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 271848004284 active site 271848004285 phosphorylation site [posttranslational modification] 271848004286 intermolecular recognition site; other site 271848004287 dimerization interface [polypeptide binding]; other site 271848004288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004289 DNA binding residues [nucleotide binding] 271848004290 dimerization interface [polypeptide binding]; other site 271848004291 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 271848004292 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848004293 Phosphoesterase family; Region: Phosphoesterase; cl15450 271848004294 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 271848004295 H-type lectin domain; Region: H_lectin; pfam09458 271848004296 cytosine deaminase; Provisional; Region: PRK09230 271848004297 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 271848004298 active site 271848004299 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 271848004300 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 271848004301 Helix-turn-helix domains; Region: HTH; cl00088 271848004302 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 271848004303 Na binding site [ion binding]; other site 271848004304 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848004305 active site 271848004306 metal binding site [ion binding]; metal-binding site 271848004307 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004308 trimer interface [polypeptide binding]; other site 271848004309 eyelet of channel; other site 271848004310 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848004311 transcriptional regulator; Provisional; Region: PRK10632 271848004312 Helix-turn-helix domains; Region: HTH; cl00088 271848004313 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848004314 putative effector binding pocket; other site 271848004315 dimerization interface [polypeptide binding]; other site 271848004316 Fusaric acid resistance protein family; Region: FUSC; pfam04632 271848004317 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 271848004318 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 271848004319 catalytic core [active] 271848004320 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 271848004321 homodimer interface [polypeptide binding]; other site 271848004322 homotetramer interface [polypeptide binding]; other site 271848004323 active site pocket [active] 271848004324 cleavage site 271848004325 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 271848004326 transcriptional regulator NarP; Provisional; Region: PRK10403 271848004327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004328 DNA binding residues [nucleotide binding] 271848004329 dimerization interface [polypeptide binding]; other site 271848004330 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 271848004331 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 271848004332 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 271848004333 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848004334 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848004335 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848004336 substrate binding pocket [chemical binding]; other site 271848004337 membrane-bound complex binding site; other site 271848004338 hinge residues; other site 271848004339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848004340 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848004341 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 271848004342 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848004343 tetrameric interface [polypeptide binding]; other site 271848004344 NAD binding site [chemical binding]; other site 271848004345 catalytic residues [active] 271848004346 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 271848004347 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848004348 inhibitor-cofactor binding pocket; inhibition site 271848004349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004350 catalytic residue [active] 271848004351 Helix-turn-helix domains; Region: HTH; cl00088 271848004352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848004353 dimerization interface [polypeptide binding]; other site 271848004354 Cupin domain; Region: Cupin_2; cl09118 271848004355 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029 271848004356 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 271848004357 dimer interface [polypeptide binding]; other site 271848004358 PYR/PP interface [polypeptide binding]; other site 271848004359 TPP binding site [chemical binding]; other site 271848004360 substrate binding site [chemical binding]; other site 271848004361 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 271848004362 TPP-binding site; other site 271848004363 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 271848004364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848004365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848004366 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004367 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004368 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004369 active site 271848004370 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 271848004371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848004372 S-adenosylmethionine binding site [chemical binding]; other site 271848004373 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848004374 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848004375 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004376 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004377 active site 271848004378 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004379 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004380 putative NADP binding site [chemical binding]; other site 271848004381 active site 271848004382 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004383 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004384 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004385 active site 271848004386 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 271848004387 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004388 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004389 putative NADP binding site [chemical binding]; other site 271848004390 active site 271848004391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848004392 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004393 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004394 active site 271848004395 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004396 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004397 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004398 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004399 active site 271848004400 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 271848004401 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004402 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004403 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004404 active site 271848004405 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004406 putative NADP binding site [chemical binding]; other site 271848004407 active site 271848004408 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004409 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004410 active site 271848004411 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004412 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004413 putative NADP binding site [chemical binding]; other site 271848004414 active site 271848004415 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004416 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004417 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004418 active site 271848004419 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004420 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004421 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004422 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004423 active site 271848004424 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004425 putative NADP binding site [chemical binding]; other site 271848004426 active site 271848004427 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004428 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004429 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004430 active site 271848004431 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848004432 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 271848004433 substrate binding site [chemical binding]; other site 271848004434 oxyanion hole (OAH) forming residues; other site 271848004435 trimer interface [polypeptide binding]; other site 271848004436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848004437 substrate binding site [chemical binding]; other site 271848004438 oxyanion hole (OAH) forming residues; other site 271848004439 trimer interface [polypeptide binding]; other site 271848004440 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 271848004441 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 271848004442 dimer interface [polypeptide binding]; other site 271848004443 active site 271848004444 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 271848004445 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 271848004446 dimer interface [polypeptide binding]; other site 271848004447 active site 271848004448 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004449 peptide synthase; Provisional; Region: PRK12467 271848004450 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848004451 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004453 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004454 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004455 active site 271848004456 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004457 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004458 putative NADP binding site [chemical binding]; other site 271848004459 active site 271848004460 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004461 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004462 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004463 active site 271848004464 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004465 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004466 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004467 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004468 active site 271848004469 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004470 putative NADP binding site [chemical binding]; other site 271848004471 active site 271848004472 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004473 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004474 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004475 active site 271848004476 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004478 NAD(P) binding site [chemical binding]; other site 271848004479 active site 271848004480 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004481 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004482 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004483 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004484 active site 271848004485 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004486 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004487 putative NADP binding site [chemical binding]; other site 271848004488 active site 271848004489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848004490 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004491 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 271848004492 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004493 active site 271848004494 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004495 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848004496 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848004497 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848004498 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848004499 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 271848004500 FMN binding site [chemical binding]; other site 271848004501 substrate binding site [chemical binding]; other site 271848004502 putative catalytic residue [active] 271848004503 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271848004504 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 271848004505 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004506 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 271848004507 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848004508 active site 271848004509 metal binding site [ion binding]; metal-binding site 271848004510 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848004511 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848004512 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 271848004513 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848004514 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848004515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004516 dimerization interface [polypeptide binding]; other site 271848004517 DNA binding residues [nucleotide binding] 271848004518 Cache domain; Region: Cache_1; pfam02743 271848004519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848004520 dimer interface [polypeptide binding]; other site 271848004521 putative CheW interface [polypeptide binding]; other site 271848004522 acyl-CoA synthetase; Validated; Region: PRK08162 271848004523 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004524 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848004525 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848004526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848004527 ligand binding site [chemical binding]; other site 271848004528 flexible hinge region; other site 271848004529 Helix-turn-helix domains; Region: HTH; cl00088 271848004530 Cupin domain; Region: Cupin_2; cl09118 271848004531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004532 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848004533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004534 LysE type translocator; Region: LysE; cl00565 271848004535 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 271848004536 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271848004537 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848004538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848004539 DNA-binding site [nucleotide binding]; DNA binding site 271848004540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848004541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004542 homodimer interface [polypeptide binding]; other site 271848004543 catalytic residue [active] 271848004544 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848004545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004546 NAD(P) binding site [chemical binding]; other site 271848004547 active site 271848004548 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 271848004549 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 271848004550 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 271848004551 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848004552 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 271848004553 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 271848004554 NAD binding site [chemical binding]; other site 271848004555 homotetramer interface [polypeptide binding]; other site 271848004556 homodimer interface [polypeptide binding]; other site 271848004557 substrate binding site [chemical binding]; other site 271848004558 active site 271848004559 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 271848004560 active site 271848004561 FMN binding site [chemical binding]; other site 271848004562 substrate binding site [chemical binding]; other site 271848004563 homotetramer interface [polypeptide binding]; other site 271848004564 catalytic residue [active] 271848004565 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 271848004566 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 271848004567 potential catalytic triad [active] 271848004568 conserved cys residue [active] 271848004569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848004570 Helix-turn-helix domains; Region: HTH; cl00088 271848004571 TfuA-like protein; Region: TfuA; pfam07812 271848004572 YcaO-like family; Region: YcaO; pfam02624 271848004573 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 271848004574 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848004575 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848004576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848004577 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 271848004578 FeS/SAM binding site; other site 271848004579 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 271848004580 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 271848004581 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 271848004582 B12 binding site [chemical binding]; other site 271848004583 Cupin superfamily protein; Region: Cupin_4; pfam08007 271848004584 JmjC domain, hydroxylase; Region: JmjC; cl15814 271848004585 Ubiquitin-like proteins; Region: UBQ; cl00155 271848004586 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 271848004587 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 271848004588 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 271848004589 probable methyltransferase; Region: TIGR03438 271848004590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848004591 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 271848004592 TIGR03440 family protein; Region: unchr_TIGR03440 271848004593 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 271848004594 Domain of unknown function (DUF427); Region: DUF427; cl00998 271848004595 alanine racemase; Reviewed; Region: PRK13340 271848004596 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 271848004597 active site 271848004598 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848004599 substrate binding site [chemical binding]; other site 271848004600 catalytic residues [active] 271848004601 dimer interface [polypeptide binding]; other site 271848004602 enoyl-CoA hydratase; Validated; Region: PRK08139 271848004603 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848004604 substrate binding site [chemical binding]; other site 271848004605 oxyanion hole (OAH) forming residues; other site 271848004606 trimer interface [polypeptide binding]; other site 271848004607 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004608 trimer interface [polypeptide binding]; other site 271848004609 eyelet of channel; other site 271848004610 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 271848004611 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 271848004612 MOSC domain; Region: MOSC; pfam03473 271848004613 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271848004614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848004615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848004616 dimer interface [polypeptide binding]; other site 271848004617 phosphorylation site [posttranslational modification] 271848004618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848004619 ATP binding site [chemical binding]; other site 271848004620 Mg2+ binding site [ion binding]; other site 271848004621 G-X-G motif; other site 271848004622 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 271848004623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004624 active site 271848004625 phosphorylation site [posttranslational modification] 271848004626 intermolecular recognition site; other site 271848004627 dimerization interface [polypeptide binding]; other site 271848004628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848004629 DNA binding site [nucleotide binding] 271848004630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848004631 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 271848004632 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 271848004633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848004634 dimer interface [polypeptide binding]; other site 271848004635 conserved gate region; other site 271848004636 ABC-ATPase subunit interface; other site 271848004637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848004638 dimer interface [polypeptide binding]; other site 271848004639 conserved gate region; other site 271848004640 putative PBP binding loops; other site 271848004641 ABC-ATPase subunit interface; other site 271848004642 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 271848004643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848004644 Walker A/P-loop; other site 271848004645 ATP binding site [chemical binding]; other site 271848004646 Q-loop/lid; other site 271848004647 ABC transporter signature motif; other site 271848004648 Walker B; other site 271848004649 D-loop; other site 271848004650 H-loop/switch region; other site 271848004651 TOBE domain; Region: TOBE_2; cl01440 271848004652 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004653 trimer interface [polypeptide binding]; other site 271848004654 eyelet of channel; other site 271848004655 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 271848004656 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848004657 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848004658 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 271848004659 putative substrate binding pocket [chemical binding]; other site 271848004660 trimer interface [polypeptide binding]; other site 271848004661 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 271848004662 putative active site [active] 271848004663 putative metal binding site [ion binding]; other site 271848004664 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848004665 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 271848004666 NAD binding site [chemical binding]; other site 271848004667 catalytic residues [active] 271848004668 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 271848004669 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848004670 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848004671 Helix-turn-helix domains; Region: HTH; cl00088 271848004672 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848004673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004674 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 271848004675 NAD(P) binding site [chemical binding]; other site 271848004676 active site 271848004677 MltA-interacting protein MipA; Region: MipA; cl01504 271848004678 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 271848004679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004680 active site 271848004681 phosphorylation site [posttranslational modification] 271848004682 intermolecular recognition site; other site 271848004683 dimerization interface [polypeptide binding]; other site 271848004684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848004685 DNA binding site [nucleotide binding] 271848004686 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848004687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 271848004688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848004689 dimer interface [polypeptide binding]; other site 271848004690 phosphorylation site [posttranslational modification] 271848004691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848004692 ATP binding site [chemical binding]; other site 271848004693 Mg2+ binding site [ion binding]; other site 271848004694 G-X-G motif; other site 271848004695 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 271848004696 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 271848004697 active site 271848004698 non-prolyl cis peptide bond; other site 271848004699 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 271848004700 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 271848004701 Flavin binding site [chemical binding]; other site 271848004702 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 271848004703 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 271848004704 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848004705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004706 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 271848004707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271848004708 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 271848004709 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 271848004710 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271848004711 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 271848004712 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271848004713 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271848004714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848004715 DNA binding site [nucleotide binding] 271848004716 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 271848004717 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 271848004718 active site 271848004719 dimer interface [polypeptide binding]; other site 271848004720 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271848004721 Ligand Binding Site [chemical binding]; other site 271848004722 Molecular Tunnel; other site 271848004723 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271848004724 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848004725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848004726 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848004727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004728 DNA binding residues [nucleotide binding] 271848004729 dimerization interface [polypeptide binding]; other site 271848004730 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 271848004731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848004732 putative transporter; Provisional; Region: PRK10504 271848004733 putative substrate translocation pore; other site 271848004734 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 271848004735 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 271848004736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 271848004737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848004738 Coenzyme A binding pocket [chemical binding]; other site 271848004739 Phospholipid methyltransferase; Region: PEMT; cl00763 271848004740 TfoX N-terminal domain; Region: TfoX_N; cl01167 271848004741 hypothetical protein; Provisional; Region: PRK07907 271848004742 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 271848004743 metal binding site [ion binding]; metal-binding site 271848004744 putative dimer interface [polypeptide binding]; other site 271848004745 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 271848004746 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848004747 conserved cys residue [active] 271848004748 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848004749 active site residue [active] 271848004750 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 271848004751 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 271848004752 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848004753 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848004754 putative active site [active] 271848004755 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 271848004756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004757 active site 271848004758 phosphorylation site [posttranslational modification] 271848004759 intermolecular recognition site; other site 271848004760 dimerization interface [polypeptide binding]; other site 271848004761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848004762 DNA binding site [nucleotide binding] 271848004763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848004764 dimer interface [polypeptide binding]; other site 271848004765 phosphorylation site [posttranslational modification] 271848004766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848004767 ATP binding site [chemical binding]; other site 271848004768 Mg2+ binding site [ion binding]; other site 271848004769 G-X-G motif; other site 271848004770 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271848004771 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848004772 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 271848004773 C-terminal domain interface [polypeptide binding]; other site 271848004774 GSH binding site (G-site) [chemical binding]; other site 271848004775 dimer interface [polypeptide binding]; other site 271848004776 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 271848004777 N-terminal domain interface [polypeptide binding]; other site 271848004778 dimer interface [polypeptide binding]; other site 271848004779 substrate binding pocket (H-site) [chemical binding]; other site 271848004780 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 271848004781 putative dimer interface [polypeptide binding]; other site 271848004782 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848004783 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 271848004784 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 271848004785 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 271848004786 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 271848004787 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 271848004788 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 271848004789 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 271848004790 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 271848004791 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 271848004792 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 271848004793 Cytochrome c; Region: Cytochrom_C; cl11414 271848004794 Cytochrome c; Region: Cytochrom_C; cl11414 271848004795 rod shape-determining protein MreB; Provisional; Region: PRK13930 271848004796 Cell division protein FtsA; Region: FtsA; cl11496 271848004797 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 271848004798 active site 271848004799 nucleophile elbow; other site 271848004800 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271848004801 Surface antigen; Region: Bac_surface_Ag; cl03097 271848004802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848004803 dimer interface [polypeptide binding]; other site 271848004804 phosphorylation site [posttranslational modification] 271848004805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848004806 ATP binding site [chemical binding]; other site 271848004807 Mg2+ binding site [ion binding]; other site 271848004808 G-X-G motif; other site 271848004809 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 271848004810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004811 active site 271848004812 phosphorylation site [posttranslational modification] 271848004813 intermolecular recognition site; other site 271848004814 dimerization interface [polypeptide binding]; other site 271848004815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848004816 DNA binding site [nucleotide binding] 271848004817 Glutaminase; Region: Glutaminase; cl00907 271848004818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 271848004819 Glutaminase; Region: Glutaminase; cl00907 271848004820 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 271848004821 B1 nucleotide binding pocket [chemical binding]; other site 271848004822 B2 nucleotide binding pocket [chemical binding]; other site 271848004823 CAS motifs; other site 271848004824 active site 271848004825 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 271848004826 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 271848004827 active site 271848004828 dimer interface [polypeptide binding]; other site 271848004829 non-prolyl cis peptide bond; other site 271848004830 insertion regions; other site 271848004831 macrolide transporter subunit MacA; Provisional; Region: PRK11578 271848004832 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848004833 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 271848004834 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271848004835 Walker A/P-loop; other site 271848004836 ATP binding site [chemical binding]; other site 271848004837 Q-loop/lid; other site 271848004838 ABC transporter signature motif; other site 271848004839 Walker B; other site 271848004840 D-loop; other site 271848004841 H-loop/switch region; other site 271848004842 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271848004843 FtsX-like permease family; Region: FtsX; cl15850 271848004844 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848004845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848004846 Helix-turn-helix domains; Region: HTH; cl00088 271848004847 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 271848004848 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004849 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004850 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848004851 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 271848004852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848004853 substrate binding site [chemical binding]; other site 271848004854 oxyanion hole (OAH) forming residues; other site 271848004855 trimer interface [polypeptide binding]; other site 271848004856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 271848004857 enoyl-CoA hydratase; Provisional; Region: PRK09076 271848004858 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848004859 substrate binding site [chemical binding]; other site 271848004860 oxyanion hole (OAH) forming residues; other site 271848004861 trimer interface [polypeptide binding]; other site 271848004862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004863 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 271848004864 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 271848004865 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848004866 tetrameric interface [polypeptide binding]; other site 271848004867 NAD binding site [chemical binding]; other site 271848004868 catalytic residues [active] 271848004869 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 271848004870 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848004872 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848004873 active site 271848004874 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848004875 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848004876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004877 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 271848004878 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 271848004879 active site residues [active] 271848004880 dimer interface [polypeptide binding]; other site 271848004881 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 271848004882 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 271848004883 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 271848004884 active site 271848004885 short chain dehydrogenase; Validated; Region: PRK05855 271848004886 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848004887 classical (c) SDRs; Region: SDR_c; cd05233 271848004888 NAD(P) binding site [chemical binding]; other site 271848004889 active site 271848004890 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848004891 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848004892 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 271848004893 NlpC/P60 family; Region: NLPC_P60; cl11438 271848004894 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 271848004895 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 271848004896 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 271848004897 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 271848004898 GAF domain; Region: GAF; cl15785 271848004899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848004900 Walker A motif; other site 271848004901 ATP binding site [chemical binding]; other site 271848004902 Walker B motif; other site 271848004903 arginine finger; other site 271848004904 Helix-turn-helix domains; Region: HTH; cl00088 271848004905 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848004906 catalytic loop [active] 271848004907 iron binding site [ion binding]; other site 271848004908 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 271848004909 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 271848004910 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 271848004911 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 271848004912 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 271848004913 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 271848004914 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848004915 N-terminal plug; other site 271848004916 ligand-binding site [chemical binding]; other site 271848004917 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848004918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848004919 Walker A/P-loop; other site 271848004920 ATP binding site [chemical binding]; other site 271848004921 Q-loop/lid; other site 271848004922 ABC transporter signature motif; other site 271848004923 Walker B; other site 271848004924 D-loop; other site 271848004925 H-loop/switch region; other site 271848004926 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 271848004927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848004928 Walker A/P-loop; other site 271848004929 ATP binding site [chemical binding]; other site 271848004930 Q-loop/lid; other site 271848004931 ABC transporter signature motif; other site 271848004932 Walker B; other site 271848004933 D-loop; other site 271848004934 H-loop/switch region; other site 271848004935 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 271848004936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004937 Condensation domain; Region: Condensation; pfam00668 271848004938 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848004939 Nonribosomal peptide synthase; Region: NRPS; pfam08415 271848004940 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848004942 peptide synthase; Provisional; Region: PRK12467 271848004943 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004944 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004945 Condensation domain; Region: Condensation; pfam00668 271848004946 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848004947 Nonribosomal peptide synthase; Region: NRPS; pfam08415 271848004948 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004949 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 271848004950 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848004952 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004953 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 271848004954 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004955 AMP-binding enzyme; Region: AMP-binding; cl15778 271848004956 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848004957 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 271848004958 nucleophilic elbow; other site 271848004959 catalytic triad; other site 271848004960 Chorismate mutase type II; Region: CM_2; cl00693 271848004961 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 271848004962 chorismate binding enzyme; Region: Chorismate_bind; cl10555 271848004963 Peptidase family M23; Region: Peptidase_M23; pfam01551 271848004964 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 271848004965 Bacterial SH3 domain; Region: SH3_3; cl02551 271848004966 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 271848004967 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271848004968 Walker A/P-loop; other site 271848004969 ATP binding site [chemical binding]; other site 271848004970 Q-loop/lid; other site 271848004971 ABC transporter signature motif; other site 271848004972 Walker B; other site 271848004973 D-loop; other site 271848004974 H-loop/switch region; other site 271848004975 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 271848004976 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 271848004977 Walker A/P-loop; other site 271848004978 ATP binding site [chemical binding]; other site 271848004979 Q-loop/lid; other site 271848004980 ABC transporter signature motif; other site 271848004981 Walker B; other site 271848004982 D-loop; other site 271848004983 H-loop/switch region; other site 271848004984 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 271848004985 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 271848004986 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848004987 TM-ABC transporter signature motif; other site 271848004988 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848004989 TM-ABC transporter signature motif; other site 271848004990 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 271848004991 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848004992 dimerization interface [polypeptide binding]; other site 271848004993 ligand binding site [chemical binding]; other site 271848004994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004995 FAD dependent oxidoreductase; Region: DAO; pfam01266 271848004996 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 271848004997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004998 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 271848004999 short chain dehydrogenase; Provisional; Region: PRK06197 271848005000 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 271848005001 putative NAD(P) binding site [chemical binding]; other site 271848005002 active site 271848005003 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848005004 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848005005 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271848005006 active site 271848005007 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 271848005008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848005009 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848005010 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 271848005011 NMT1-like family; Region: NMT1_2; cl15260 271848005012 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 271848005013 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848005014 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848005015 conserved cys residue [active] 271848005016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005017 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 271848005018 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 271848005019 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848005020 Zn binding site [ion binding]; other site 271848005021 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 271848005022 active site 271848005023 metal binding site [ion binding]; metal-binding site 271848005024 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848005025 trimer interface [polypeptide binding]; other site 271848005026 eyelet of channel; other site 271848005027 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 271848005028 NMT1-like family; Region: NMT1_2; cl15260 271848005029 choline-sulfatase; Region: chol_sulfatase; TIGR03417 271848005030 Sulfatase; Region: Sulfatase; cl10460 271848005031 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 271848005032 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 271848005033 Helix-turn-helix domains; Region: HTH; cl00088 271848005034 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848005035 dimerization interface [polypeptide binding]; other site 271848005036 substrate binding pocket [chemical binding]; other site 271848005037 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 271848005038 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 271848005039 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 271848005040 putative active site [active] 271848005041 putative substrate binding site [chemical binding]; other site 271848005042 putative cosubstrate binding site; other site 271848005043 catalytic site [active] 271848005044 Amino acid permease; Region: AA_permease_2; pfam13520 271848005045 NMT1-like family; Region: NMT1_2; cl15260 271848005046 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 271848005047 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 271848005048 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 271848005049 FAD binding pocket [chemical binding]; other site 271848005050 FAD binding motif [chemical binding]; other site 271848005051 phosphate binding motif [ion binding]; other site 271848005052 beta-alpha-beta structure motif; other site 271848005053 NAD binding pocket [chemical binding]; other site 271848005054 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848005055 catalytic loop [active] 271848005056 iron binding site [ion binding]; other site 271848005057 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848005058 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 271848005059 [2Fe-2S] cluster binding site [ion binding]; other site 271848005060 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 271848005061 putative alpha subunit interface [polypeptide binding]; other site 271848005062 putative active site [active] 271848005063 putative substrate binding site [chemical binding]; other site 271848005064 Fe binding site [ion binding]; other site 271848005065 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 271848005066 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 271848005067 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 271848005068 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 271848005069 Cysteine-rich domain; Region: CCG; pfam02754 271848005070 Cysteine-rich domain; Region: CCG; pfam02754 271848005071 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 271848005072 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 271848005073 putative active site [active] 271848005074 putative FMN binding site [chemical binding]; other site 271848005075 putative substrate binding site [chemical binding]; other site 271848005076 putative catalytic residue [active] 271848005077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848005078 Heme NO binding; Region: HNOB; cl15268 271848005079 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 271848005080 active site 271848005081 dimer interface [polypeptide binding]; other site 271848005082 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 271848005083 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 271848005084 dimer interface [polypeptide binding]; other site 271848005085 active site 271848005086 glycine-pyridoxal phosphate binding site [chemical binding]; other site 271848005087 folate binding site [chemical binding]; other site 271848005088 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848005089 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848005090 conserved cys residue [active] 271848005091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005092 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 271848005093 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 271848005094 NAD binding site [chemical binding]; other site 271848005095 catalytic Zn binding site [ion binding]; other site 271848005096 structural Zn binding site [ion binding]; other site 271848005097 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848005098 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848005099 DNA binding site [nucleotide binding] 271848005100 domain linker motif; other site 271848005101 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 271848005102 ligand binding site [chemical binding]; other site 271848005103 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 271848005104 active site 271848005105 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 271848005106 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 271848005107 substrate binding [chemical binding]; other site 271848005108 active site 271848005109 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 271848005110 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 271848005111 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848005112 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848005113 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848005114 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 271848005115 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 271848005116 Ligand binding site; other site 271848005117 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848005118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005119 putative substrate translocation pore; other site 271848005120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005121 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 271848005122 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 271848005123 active site 271848005124 TDP-binding site; other site 271848005125 acceptor substrate-binding pocket; other site 271848005126 homodimer interface [polypeptide binding]; other site 271848005127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848005128 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 271848005129 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 271848005130 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848005131 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271848005132 hypothetical protein; Provisional; Region: PRK14693 271848005133 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 271848005134 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848005135 ligand binding site [chemical binding]; other site 271848005136 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 271848005137 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848005138 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 271848005139 PAAR motif; Region: PAAR_motif; cl15808 271848005140 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 271848005141 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848005142 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 271848005143 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848005144 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 271848005145 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848005146 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 271848005147 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848005148 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848005149 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848005150 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848005151 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848005152 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848005153 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848005154 Clp amino terminal domain; Region: Clp_N; pfam02861 271848005155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848005156 Walker A motif; other site 271848005157 ATP binding site [chemical binding]; other site 271848005158 Walker B motif; other site 271848005159 arginine finger; other site 271848005160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848005161 Walker A motif; other site 271848005162 ATP binding site [chemical binding]; other site 271848005163 Walker B motif; other site 271848005164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848005165 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 271848005166 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848005167 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848005168 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848005169 Protein of unknown function (DUF796); Region: DUF796; cl01226 271848005170 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 271848005171 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848005172 Protein of unknown function (DUF770); Region: DUF770; cl01402 271848005173 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271848005174 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848005175 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 271848005176 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 271848005177 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 271848005178 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 271848005179 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848005180 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 271848005181 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 271848005182 active site 271848005183 metal-binding site 271848005184 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 271848005185 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 271848005186 tetramer interface [polypeptide binding]; other site 271848005187 active site 271848005188 Mg2+/Mn2+ binding site [ion binding]; other site 271848005189 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 271848005190 active site 271848005191 metal-binding site 271848005192 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848005193 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 271848005194 PYR/PP interface [polypeptide binding]; other site 271848005195 dimer interface [polypeptide binding]; other site 271848005196 TPP binding site [chemical binding]; other site 271848005197 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 271848005198 TPP-binding site [chemical binding]; other site 271848005199 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 271848005200 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848005201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848005202 catalytic residue [active] 271848005203 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 271848005204 conserved cys residue [active] 271848005205 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848005206 conserved cys residue [active] 271848005207 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848005208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005209 Predicted membrane protein [Function unknown]; Region: COG1289 271848005210 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 271848005211 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848005212 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848005213 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848005214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005216 putative substrate translocation pore; other site 271848005217 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848005218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848005219 DNA-binding site [nucleotide binding]; DNA binding site 271848005220 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848005221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005222 homodimer interface [polypeptide binding]; other site 271848005223 catalytic residue [active] 271848005224 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 271848005225 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 271848005226 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271848005227 Uncharacterized conserved protein [Function unknown]; Region: COG2308 271848005228 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 271848005229 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 271848005230 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 271848005231 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271848005232 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 271848005233 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 271848005234 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 271848005235 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 271848005236 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271848005237 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 271848005238 Uncharacterized conserved protein [Function unknown]; Region: COG2308 271848005239 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 271848005240 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 271848005241 putative FMN binding site [chemical binding]; other site 271848005242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 271848005243 Chitin binding domain; Region: Chitin_bind_3; cl03871 271848005244 peroxiredoxin; Region: AhpC; TIGR03137 271848005245 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 271848005246 dimer interface [polypeptide binding]; other site 271848005247 decamer (pentamer of dimers) interface [polypeptide binding]; other site 271848005248 catalytic triad [active] 271848005249 peroxidatic and resolving cysteines [active] 271848005250 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 271848005251 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 271848005252 catalytic residue [active] 271848005253 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 271848005254 catalytic residues [active] 271848005255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848005256 MAPEG family; Region: MAPEG; cl09190 271848005257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848005258 acyl-CoA synthetase; Validated; Region: PRK05850 271848005259 AMP-binding enzyme; Region: AMP-binding; cl15778 271848005260 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848005261 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 271848005262 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271848005263 active site 271848005264 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005265 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848005266 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 271848005267 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 271848005268 dimer interface [polypeptide binding]; other site 271848005269 active site 271848005270 CoA binding pocket [chemical binding]; other site 271848005271 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 271848005272 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 271848005273 active site 271848005274 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 271848005275 AMP-binding enzyme; Region: AMP-binding; cl15778 271848005276 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848005277 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 271848005278 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 271848005279 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 271848005280 active site 271848005281 dimer interface [polypeptide binding]; other site 271848005282 effector binding site; other site 271848005283 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 271848005284 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 271848005285 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 271848005286 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 271848005287 ring oligomerisation interface [polypeptide binding]; other site 271848005288 ATP/Mg binding site [chemical binding]; other site 271848005289 stacking interactions; other site 271848005290 hinge regions; other site 271848005291 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 271848005292 oligomerisation interface [polypeptide binding]; other site 271848005293 mobile loop; other site 271848005294 roof hairpin; other site 271848005295 Arginase family; Region: Arginase; cl00306 271848005296 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 271848005297 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 271848005298 NAD(P) binding site [chemical binding]; other site 271848005299 catalytic residues [active] 271848005300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848005301 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 271848005302 non-specific DNA binding site [nucleotide binding]; other site 271848005303 salt bridge; other site 271848005304 sequence-specific DNA binding site [nucleotide binding]; other site 271848005305 Cupin domain; Region: Cupin_2; cl09118 271848005306 Peptidase C26; Region: Peptidase_C26; pfam07722 271848005307 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 271848005308 catalytic triad [active] 271848005309 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 271848005310 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 271848005311 putative aminotransferase; Validated; Region: PRK07480 271848005312 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848005313 inhibitor-cofactor binding pocket; inhibition site 271848005314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005315 catalytic residue [active] 271848005316 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 271848005317 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848005318 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 271848005319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848005320 Walker A/P-loop; other site 271848005321 ATP binding site [chemical binding]; other site 271848005322 Q-loop/lid; other site 271848005323 ABC transporter signature motif; other site 271848005324 Walker B; other site 271848005325 D-loop; other site 271848005326 H-loop/switch region; other site 271848005327 TOBE domain; Region: TOBE_2; cl01440 271848005328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848005329 dimer interface [polypeptide binding]; other site 271848005330 conserved gate region; other site 271848005331 putative PBP binding loops; other site 271848005332 ABC-ATPase subunit interface; other site 271848005333 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 271848005334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848005335 dimer interface [polypeptide binding]; other site 271848005336 conserved gate region; other site 271848005337 putative PBP binding loops; other site 271848005338 ABC-ATPase subunit interface; other site 271848005339 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 271848005340 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 271848005341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848005342 FAD dependent oxidoreductase; Region: DAO; pfam01266 271848005343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848005344 FAD dependent oxidoreductase; Region: DAO; pfam01266 271848005345 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 271848005346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848005347 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848005348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848005349 dimer interface [polypeptide binding]; other site 271848005350 putative CheW interface [polypeptide binding]; other site 271848005351 Copper resistance protein D; Region: CopD; cl00563 271848005352 Copper resistance protein D; Region: CopD; cl00563 271848005353 Bacterial Ig-like domain; Region: Big_5; cl01012 271848005354 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 271848005355 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848005356 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848005357 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 271848005358 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 271848005359 hypothetical protein; Provisional; Region: PRK08609 271848005360 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 271848005361 active site 271848005362 primer binding site [nucleotide binding]; other site 271848005363 NTP binding site [chemical binding]; other site 271848005364 metal binding triad [ion binding]; metal-binding site 271848005365 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 271848005366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848005367 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 271848005368 conserved cys residue [active] 271848005369 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848005370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848005371 DNA-binding site [nucleotide binding]; DNA binding site 271848005372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848005373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005374 homodimer interface [polypeptide binding]; other site 271848005375 catalytic residue [active] 271848005376 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 271848005377 NAD binding site [chemical binding]; other site 271848005378 active site 271848005379 Pirin-related protein [General function prediction only]; Region: COG1741 271848005380 Cupin domain; Region: Cupin_2; cl09118 271848005381 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848005382 Helix-turn-helix domains; Region: HTH; cl00088 271848005383 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848005384 putative effector binding pocket; other site 271848005385 dimerization interface [polypeptide binding]; other site 271848005386 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 271848005387 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 271848005388 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848005389 active site 271848005390 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848005391 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 271848005392 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 271848005393 trimer interface [polypeptide binding]; other site 271848005394 active site 271848005395 substrate binding site [chemical binding]; other site 271848005396 CoA binding site [chemical binding]; other site 271848005397 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848005398 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848005399 putative active site [active] 271848005400 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848005401 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848005402 putative active site [active] 271848005403 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848005404 active site 271848005405 MatE; Region: MatE; cl10513 271848005406 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848005407 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 271848005408 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271848005409 inhibitor-cofactor binding pocket; inhibition site 271848005410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005411 catalytic residue [active] 271848005412 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 271848005413 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271848005414 inhibitor-cofactor binding pocket; inhibition site 271848005415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005416 catalytic residue [active] 271848005417 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 271848005418 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 271848005419 NAD binding site [chemical binding]; other site 271848005420 homotetramer interface [polypeptide binding]; other site 271848005421 homodimer interface [polypeptide binding]; other site 271848005422 substrate binding site [chemical binding]; other site 271848005423 active site 271848005424 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 271848005425 substrate binding site; other site 271848005426 Chain length determinant protein; Region: Wzz; cl15801 271848005427 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 271848005428 Chain length determinant protein; Region: Wzz; cl15801 271848005429 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 271848005430 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848005431 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 271848005432 SLBB domain; Region: SLBB; pfam10531 271848005433 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 271848005434 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 271848005435 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 271848005436 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 271848005437 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 271848005438 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848005439 PYR/PP interface [polypeptide binding]; other site 271848005440 dimer interface [polypeptide binding]; other site 271848005441 TPP binding site [chemical binding]; other site 271848005442 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271848005443 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 271848005444 TPP-binding site [chemical binding]; other site 271848005445 dimer interface [polypeptide binding]; other site 271848005446 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 271848005447 Bacterial Ig-like domain; Region: Big_5; cl01012 271848005448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848005449 active site 271848005450 DNA binding site [nucleotide binding] 271848005451 Int/Topo IB signature motif; other site 271848005452 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 271848005453 YcfA-like protein; Region: YcfA; cl00752 271848005454 PAAR motif; Region: PAAR_motif; cl15808 271848005455 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 271848005456 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 271848005457 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 271848005458 multiple promoter invertase; Provisional; Region: mpi; PRK13413 271848005459 catalytic residues [active] 271848005460 catalytic nucleophile [active] 271848005461 Presynaptic Site I dimer interface [polypeptide binding]; other site 271848005462 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 271848005463 Synaptic Flat tetramer interface [polypeptide binding]; other site 271848005464 Synaptic Site I dimer interface [polypeptide binding]; other site 271848005465 DNA binding site [nucleotide binding] 271848005466 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848005467 DNA-binding interface [nucleotide binding]; DNA binding site 271848005468 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848005469 AAA domain; Region: AAA_18; pfam13238 271848005470 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848005471 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 271848005472 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 271848005473 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 271848005474 Domain of unknown function (DUF927); Region: DUF927; cl12098 271848005475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848005476 non-specific DNA binding site [nucleotide binding]; other site 271848005477 salt bridge; other site 271848005478 sequence-specific DNA binding site [nucleotide binding]; other site 271848005479 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848005480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848005481 non-specific DNA binding site [nucleotide binding]; other site 271848005482 salt bridge; other site 271848005483 sequence-specific DNA binding site [nucleotide binding]; other site 271848005484 integrase; Provisional; Region: PRK09692 271848005485 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 271848005486 active site 271848005487 Int/Topo IB signature motif; other site 271848005488 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 271848005489 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 271848005490 Na binding site [ion binding]; other site 271848005491 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 271848005492 acetyl-CoA synthetase; Provisional; Region: PRK00174 271848005493 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 271848005494 AMP-binding enzyme; Region: AMP-binding; cl15778 271848005495 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848005496 EamA-like transporter family; Region: EamA; cl01037 271848005497 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271848005498 EamA-like transporter family; Region: EamA; cl01037 271848005499 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 271848005500 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 271848005501 Fumarase C-terminus; Region: Fumerase_C; cl00795 271848005502 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 271848005503 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 271848005504 heme binding site [chemical binding]; other site 271848005505 ferroxidase pore; other site 271848005506 ferroxidase diiron center [ion binding]; other site 271848005507 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 271848005508 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271848005509 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271848005510 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271848005511 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271848005512 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848005513 Helix-turn-helix domains; Region: HTH; cl00088 271848005514 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 271848005515 putative effector binding pocket; other site 271848005516 putative dimerization interface [polypeptide binding]; other site 271848005517 Pirin-related protein [General function prediction only]; Region: COG1741 271848005518 Cupin domain; Region: Cupin_2; cl09118 271848005519 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 271848005520 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 271848005521 putative hydrophobic ligand binding site [chemical binding]; other site 271848005522 Hemin uptake protein hemP; Region: hemP; cl10043 271848005523 Domain of unknown function (DUF336); Region: DUF336; cl01249 271848005524 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 271848005525 4Fe-4S binding domain; Region: Fer4_5; pfam12801 271848005526 Iron permease FTR1 family; Region: FTR1; cl00475 271848005527 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848005528 Fe2+ transport protein; Region: Iron_transport; cl01377 271848005529 excinuclease ABC subunit B; Provisional; Region: PRK05298 271848005530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848005531 ATP binding site [chemical binding]; other site 271848005532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848005533 nucleotide binding region [chemical binding]; other site 271848005534 ATP-binding site [chemical binding]; other site 271848005535 Ultra-violet resistance protein B; Region: UvrB; pfam12344 271848005536 UvrB/uvrC motif; Region: UVR; pfam02151 271848005537 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 271848005538 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848005539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005540 homodimer interface [polypeptide binding]; other site 271848005541 catalytic residue [active] 271848005542 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 271848005543 classical (c) SDRs; Region: SDR_c; cd05233 271848005544 NAD(P) binding site [chemical binding]; other site 271848005545 active site 271848005546 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 271848005547 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848005548 active site 271848005549 catalytic tetrad [active] 271848005550 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 271848005551 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 271848005552 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 271848005553 DNA binding residues [nucleotide binding] 271848005554 dimer interface [polypeptide binding]; other site 271848005555 copper binding site [ion binding]; other site 271848005556 Integrase core domain; Region: rve; cl01316 271848005557 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848005558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271848005559 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848005560 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 271848005561 NAD(P) binding site [chemical binding]; other site 271848005562 catalytic residues [active] 271848005563 Sulfatase; Region: Sulfatase; cl10460 271848005564 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 271848005565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848005567 dimer interface [polypeptide binding]; other site 271848005568 conserved gate region; other site 271848005569 putative PBP binding loops; other site 271848005570 ABC-ATPase subunit interface; other site 271848005571 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 271848005572 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848005573 Walker A/P-loop; other site 271848005574 ATP binding site [chemical binding]; other site 271848005575 Q-loop/lid; other site 271848005576 ABC transporter signature motif; other site 271848005577 Walker B; other site 271848005578 D-loop; other site 271848005579 H-loop/switch region; other site 271848005580 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 271848005581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848005582 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 271848005583 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848005584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848005585 catalytic residue [active] 271848005586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005587 D-galactonate transporter; Region: 2A0114; TIGR00893 271848005588 putative substrate translocation pore; other site 271848005589 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 271848005590 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 271848005591 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 271848005592 shikimate binding site; other site 271848005593 NAD(P) binding site [chemical binding]; other site 271848005594 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 271848005595 active site 271848005596 trimer interface [polypeptide binding]; other site 271848005597 dimer interface [polypeptide binding]; other site 271848005598 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 271848005599 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 271848005600 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 271848005601 dimer interface [polypeptide binding]; other site 271848005602 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 271848005603 active site 271848005604 Fe binding site [ion binding]; other site 271848005605 L-lactate permease; Region: Lactate_perm; cl00701 271848005606 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848005607 active site 271848005608 PAS fold; Region: PAS_4; pfam08448 271848005609 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848005610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 271848005612 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271848005613 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271848005614 FAD dependent oxidoreductase; Region: DAO; pfam01266 271848005615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848005616 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 271848005617 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 271848005618 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848005619 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 271848005620 inhibitor site; inhibition site 271848005621 active site 271848005622 dimer interface [polypeptide binding]; other site 271848005623 catalytic residue [active] 271848005624 amino acid transporter; Region: 2A0306; TIGR00909 271848005625 Spore germination protein; Region: Spore_permease; cl15802 271848005626 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 271848005627 dimer interface [polypeptide binding]; other site 271848005628 NADP binding site [chemical binding]; other site 271848005629 catalytic residues [active] 271848005630 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 271848005631 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848005632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005633 putative substrate translocation pore; other site 271848005634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005635 putative substrate translocation pore; other site 271848005636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005637 DoxX; Region: DoxX; cl00976 271848005638 glycolate transporter; Provisional; Region: PRK09695 271848005639 L-lactate permease; Region: Lactate_perm; cl00701 271848005640 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 271848005641 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 271848005642 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 271848005643 4Fe-4S binding domain; Region: Fer4; cl02805 271848005644 Cysteine-rich domain; Region: CCG; pfam02754 271848005645 Cysteine-rich domain; Region: CCG; pfam02754 271848005646 transcriptional regulator NanR; Provisional; Region: PRK03837 271848005647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848005648 DNA-binding site [nucleotide binding]; DNA binding site 271848005649 FCD domain; Region: FCD; cl11656 271848005650 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 271848005651 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 271848005652 Flavin binding site [chemical binding]; other site 271848005653 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 271848005654 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 271848005655 active site 271848005656 non-prolyl cis peptide bond; other site 271848005657 NMT1-like family; Region: NMT1_2; cl15260 271848005658 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848005659 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848005660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848005661 DNA binding residues [nucleotide binding] 271848005662 dimerization interface [polypeptide binding]; other site 271848005663 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848005664 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848005665 AMP-binding enzyme; Region: AMP-binding; cl15778 271848005666 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005667 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 271848005668 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848005669 active site 271848005670 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848005671 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848005672 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848005673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848005674 NAD(P) binding site [chemical binding]; other site 271848005675 active site 271848005676 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005677 SET domain; Region: SET; cl02566 271848005678 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 271848005679 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848005680 hypothetical protein; Provisional; Region: PRK07036 271848005681 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848005682 inhibitor-cofactor binding pocket; inhibition site 271848005683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005684 catalytic residue [active] 271848005685 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848005686 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 271848005687 tetrameric interface [polypeptide binding]; other site 271848005688 NAD binding site [chemical binding]; other site 271848005689 catalytic residues [active] 271848005690 substrate binding site [chemical binding]; other site 271848005691 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005692 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 271848005693 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848005694 active site 271848005695 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848005696 putative NADP binding site [chemical binding]; other site 271848005697 active site 271848005698 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271848005699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848005700 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005701 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848005702 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848005703 active site 271848005704 peptide synthase; Provisional; Region: PRK12316 271848005705 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005706 peptide synthase; Provisional; Region: PRK12467 271848005707 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848005708 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005709 thioester reductase domain; Region: Thioester-redct; TIGR01746 271848005710 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 271848005711 putative NAD(P) binding site [chemical binding]; other site 271848005712 active site 271848005713 putative substrate binding site [chemical binding]; other site 271848005714 Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059 271848005715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848005716 NAD+ binding site [chemical binding]; other site 271848005717 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 271848005718 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 271848005719 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 271848005720 active site 271848005721 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848005722 substrate binding site [chemical binding]; other site 271848005723 catalytic residues [active] 271848005724 dimer interface [polypeptide binding]; other site 271848005725 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005726 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848005727 AMP-binding enzyme; Region: AMP-binding; cl15778 271848005728 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848005729 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848005730 acyl-CoA synthetase; Validated; Region: PRK05850 271848005731 AMP-binding enzyme; Region: AMP-binding; cl15778 271848005732 Membrane transport protein; Region: Mem_trans; cl09117 271848005733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848005734 Predicted acetyltransferase [General function prediction only]; Region: COG3153 271848005735 Coenzyme A binding pocket [chemical binding]; other site 271848005736 Transcriptional regulators [Transcription]; Region: FadR; COG2186 271848005737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848005738 DNA-binding site [nucleotide binding]; DNA binding site 271848005739 FCD domain; Region: FCD; cl11656 271848005740 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 271848005741 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848005742 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 271848005743 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848005744 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848005745 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848005746 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848005747 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848005748 substrate binding pocket [chemical binding]; other site 271848005749 transcriptional regulator; Provisional; Region: PRK10632 271848005750 Helix-turn-helix domains; Region: HTH; cl00088 271848005751 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 271848005752 putative effector binding pocket; other site 271848005753 putative dimerization interface [polypeptide binding]; other site 271848005754 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848005755 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848005756 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848005757 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 271848005758 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848005759 active site 1 [active] 271848005760 dimer interface [polypeptide binding]; other site 271848005761 hexamer interface [polypeptide binding]; other site 271848005762 active site 2 [active] 271848005763 transcriptional activator TtdR; Provisional; Region: PRK09801 271848005764 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 271848005765 putative effector binding pocket; other site 271848005766 putative dimerization interface [polypeptide binding]; other site 271848005767 selenophosphate synthetase; Provisional; Region: PRK00943 271848005768 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 271848005769 dimerization interface [polypeptide binding]; other site 271848005770 putative ATP binding site [chemical binding]; other site 271848005771 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 271848005772 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848005773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848005774 DNA-binding site [nucleotide binding]; DNA binding site 271848005775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848005776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005777 homodimer interface [polypeptide binding]; other site 271848005778 catalytic residue [active] 271848005779 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 271848005780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848005781 inhibitor-cofactor binding pocket; inhibition site 271848005782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005783 catalytic residue [active] 271848005784 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848005785 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 271848005786 tetramerization interface [polypeptide binding]; other site 271848005787 NAD(P) binding site [chemical binding]; other site 271848005788 catalytic residues [active] 271848005789 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 271848005790 iron-sulfur cluster [ion binding]; other site 271848005791 [2Fe-2S] cluster binding site [ion binding]; other site 271848005792 O-methyltransferase; Region: Methyltransf_2; pfam00891 271848005793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848005794 PAS domain; Region: PAS_9; pfam13426 271848005795 putative active site [active] 271848005796 heme pocket [chemical binding]; other site 271848005797 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848005798 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848005799 dimer interface [polypeptide binding]; other site 271848005800 putative CheW interface [polypeptide binding]; other site 271848005801 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 271848005802 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848005803 dimer interface [polypeptide binding]; other site 271848005804 active site 271848005805 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 271848005806 Helix-turn-helix domains; Region: HTH; cl00088 271848005807 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848005808 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 271848005809 Helix-turn-helix domains; Region: HTH; cl00088 271848005810 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 271848005811 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848005812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848005813 dimerization interface [polypeptide binding]; other site 271848005814 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 271848005815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848005816 substrate binding pocket [chemical binding]; other site 271848005817 membrane-bound complex binding site; other site 271848005818 hinge residues; other site 271848005819 OpgC protein; Region: OpgC_C; cl00792 271848005820 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 271848005821 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 271848005822 active site 271848005823 Zn binding site [ion binding]; other site 271848005824 NMT1-like family; Region: NMT1_2; cl15260 271848005825 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848005826 trimer interface [polypeptide binding]; other site 271848005827 eyelet of channel; other site 271848005828 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 271848005829 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 271848005830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848005831 N-terminal plug; other site 271848005832 ligand-binding site [chemical binding]; other site 271848005833 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 271848005834 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 271848005835 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 271848005836 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 271848005837 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 271848005838 intersubunit interface [polypeptide binding]; other site 271848005839 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 271848005840 putative PBP binding regions; other site 271848005841 ABC-ATPase subunit interface; other site 271848005842 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 271848005843 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271848005844 Walker A/P-loop; other site 271848005845 ATP binding site [chemical binding]; other site 271848005846 Q-loop/lid; other site 271848005847 ABC transporter signature motif; other site 271848005848 Walker B; other site 271848005849 D-loop; other site 271848005850 H-loop/switch region; other site 271848005851 Predicted membrane protein [Function unknown]; Region: COG2860 271848005852 UPF0126 domain; Region: UPF0126; pfam03458 271848005853 UPF0126 domain; Region: UPF0126; pfam03458 271848005854 Transglycosylase; Region: Transgly; cl07896 271848005855 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 271848005856 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848005857 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 271848005858 Helix-turn-helix domains; Region: HTH; cl00088 271848005859 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 271848005860 putative dimerization interface [polypeptide binding]; other site 271848005861 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 271848005862 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 271848005863 tetramer interface [polypeptide binding]; other site 271848005864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005865 catalytic residue [active] 271848005866 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 271848005867 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 271848005868 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 271848005869 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 271848005870 FMN binding site [chemical binding]; other site 271848005871 active site 271848005872 substrate binding site [chemical binding]; other site 271848005873 catalytic residue [active] 271848005874 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848005875 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 271848005876 active site 271848005877 catalytic tetrad [active] 271848005878 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848005879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005880 putative substrate translocation pore; other site 271848005881 transcriptional regulator; Provisional; Region: PRK10632 271848005882 Helix-turn-helix domains; Region: HTH; cl00088 271848005883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848005884 dimerization interface [polypeptide binding]; other site 271848005885 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 271848005886 active site lid residues [active] 271848005887 substrate binding pocket [chemical binding]; other site 271848005888 catalytic residues [active] 271848005889 substrate-Mg2+ binding site; other site 271848005890 aspartate-rich region 1; other site 271848005891 aspartate-rich region 2; other site 271848005892 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848005893 Helix-turn-helix domains; Region: HTH; cl00088 271848005894 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848005895 putative effector binding pocket; other site 271848005896 dimerization interface [polypeptide binding]; other site 271848005897 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 271848005898 dimer interface [polypeptide binding]; other site 271848005899 FMN binding site [chemical binding]; other site 271848005900 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848005901 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848005902 substrate binding pocket [chemical binding]; other site 271848005903 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848005904 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848005905 Helix-turn-helix domains; Region: HTH; cl00088 271848005906 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848005907 putative effector binding pocket; other site 271848005908 dimerization interface [polypeptide binding]; other site 271848005909 choline dehydrogenase; Validated; Region: PRK02106 271848005910 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848005911 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848005912 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848005913 NAD(P) binding site [chemical binding]; other site 271848005914 catalytic residues [active] 271848005915 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848005916 AsmA family; Region: AsmA; pfam05170 271848005917 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271848005918 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271848005919 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271848005920 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271848005921 Uncharacterized conserved protein [Function unknown]; Region: COG5361 271848005922 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 271848005923 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 271848005924 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 271848005925 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 271848005926 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271848005927 metal-binding site [ion binding] 271848005928 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271848005929 metal-binding site [ion binding] 271848005930 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271848005931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848005932 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848005933 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 271848005934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848005935 Coenzyme A binding pocket [chemical binding]; other site 271848005936 MgtC family; Region: MgtC; pfam02308 271848005937 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 271848005938 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 271848005939 dimerization interface [polypeptide binding]; other site 271848005940 putative active cleft [active] 271848005941 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 271848005942 Helix-turn-helix domains; Region: HTH; cl00088 271848005943 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 271848005944 dimerization interface [polypeptide binding]; other site 271848005945 substrate binding pocket [chemical binding]; other site 271848005946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848005947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005948 putative substrate translocation pore; other site 271848005949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005950 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 271848005951 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 271848005952 dimer interface [polypeptide binding]; other site 271848005953 ligand binding site [chemical binding]; other site 271848005954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848005955 dimer interface [polypeptide binding]; other site 271848005956 putative CheW interface [polypeptide binding]; other site 271848005957 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 271848005958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848005959 FeS/SAM binding site; other site 271848005960 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 271848005961 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 271848005962 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 271848005963 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 271848005964 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 271848005965 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 271848005966 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848005967 CoenzymeA binding site [chemical binding]; other site 271848005968 subunit interaction site [polypeptide binding]; other site 271848005969 PHB binding site; other site 271848005970 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 271848005971 PrpF protein; Region: PrpF; pfam04303 271848005972 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 271848005973 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 271848005974 substrate binding site [chemical binding]; other site 271848005975 ligand binding site [chemical binding]; other site 271848005976 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 271848005977 substrate binding site [chemical binding]; other site 271848005978 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 271848005979 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 271848005980 dimer interface [polypeptide binding]; other site 271848005981 active site 271848005982 citrylCoA binding site [chemical binding]; other site 271848005983 oxalacetate/citrate binding site [chemical binding]; other site 271848005984 coenzyme A binding site [chemical binding]; other site 271848005985 catalytic triad [active] 271848005986 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 271848005987 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 271848005988 tetramer interface [polypeptide binding]; other site 271848005989 active site 271848005990 Mg2+/Mn2+ binding site [ion binding]; other site 271848005991 Propionate catabolism activator; Region: PrpR_N; pfam06506 271848005992 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 271848005993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848005994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848005995 Walker A motif; other site 271848005996 ATP binding site [chemical binding]; other site 271848005997 Walker B motif; other site 271848005998 arginine finger; other site 271848005999 Helix-turn-helix domains; Region: HTH; cl00088 271848006000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848006001 dimerization interface [polypeptide binding]; other site 271848006002 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848006003 dimer interface [polypeptide binding]; other site 271848006004 putative CheW interface [polypeptide binding]; other site 271848006005 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 271848006006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848006007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848006008 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 271848006009 dimer interface [polypeptide binding]; other site 271848006010 putative metal binding site [ion binding]; other site 271848006011 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 271848006012 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 271848006013 homodimer interface [polypeptide binding]; other site 271848006014 substrate-cofactor binding pocket; other site 271848006015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006016 catalytic residue [active] 271848006017 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 271848006018 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848006019 conserved cys residue [active] 271848006020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848006021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848006022 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 271848006023 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848006024 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848006025 Helix-turn-helix domains; Region: HTH; cl00088 271848006026 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848006027 DDE superfamily endonuclease; Region: DDE_5; cl02413 271848006028 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 271848006029 Amidase; Region: Amidase; cl11426 271848006030 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 271848006031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848006032 CoA-ligase; Region: Ligase_CoA; cl02894 271848006033 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848006034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 271848006035 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848006036 H-NS histone family; Region: Histone_HNS; pfam00816 271848006037 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848006038 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 271848006039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848006040 Walker B motif; other site 271848006041 arginine finger; other site 271848006042 Helix-turn-helix domains; Region: HTH; cl00088 271848006043 Citrate transporter; Region: CitMHS; pfam03600 271848006044 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271848006045 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 271848006046 active site residue [active] 271848006047 outer membrane porin, OprD family; Region: OprD; pfam03573 271848006048 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 271848006049 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848006050 Walker A/P-loop; other site 271848006051 ATP binding site [chemical binding]; other site 271848006052 Q-loop/lid; other site 271848006053 ABC transporter signature motif; other site 271848006054 Walker B; other site 271848006055 D-loop; other site 271848006056 H-loop/switch region; other site 271848006057 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848006058 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 271848006059 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848006060 Walker A/P-loop; other site 271848006061 ATP binding site [chemical binding]; other site 271848006062 Q-loop/lid; other site 271848006063 ABC transporter signature motif; other site 271848006064 Walker B; other site 271848006065 D-loop; other site 271848006066 H-loop/switch region; other site 271848006067 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848006068 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 271848006069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848006070 dimer interface [polypeptide binding]; other site 271848006071 conserved gate region; other site 271848006072 putative PBP binding loops; other site 271848006073 ABC-ATPase subunit interface; other site 271848006074 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 271848006075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848006076 dimer interface [polypeptide binding]; other site 271848006077 conserved gate region; other site 271848006078 putative PBP binding loops; other site 271848006079 ABC-ATPase subunit interface; other site 271848006080 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 271848006081 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 271848006082 peptide binding site [polypeptide binding]; other site 271848006083 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 271848006084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848006085 non-specific DNA binding site [nucleotide binding]; other site 271848006086 salt bridge; other site 271848006087 sequence-specific DNA binding site [nucleotide binding]; other site 271848006088 Cupin domain; Region: Cupin_2; cl09118 271848006089 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 271848006090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006091 putative substrate translocation pore; other site 271848006092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 271848006093 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 271848006094 Helix-turn-helix domains; Region: HTH; cl00088 271848006095 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 271848006096 substrate binding pocket [chemical binding]; other site 271848006097 dimerization interface [polypeptide binding]; other site 271848006098 Putative cyclase; Region: Cyclase; cl00814 271848006099 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 271848006100 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848006101 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848006102 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848006103 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 271848006104 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 271848006105 NAD(P) binding site [chemical binding]; other site 271848006106 Isochorismatase family; Region: Isochorismatase; pfam00857 271848006107 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 271848006108 catalytic triad [active] 271848006109 conserved cis-peptide bond; other site 271848006110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848006112 putative substrate translocation pore; other site 271848006113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006114 benzoate transport; Region: 2A0115; TIGR00895 271848006115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006117 putative substrate translocation pore; other site 271848006118 Putative cyclase; Region: Cyclase; cl00814 271848006119 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848006120 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848006121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848006122 Helix-turn-helix domains; Region: HTH; cl00088 271848006123 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848006124 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848006125 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006126 trimer interface [polypeptide binding]; other site 271848006127 eyelet of channel; other site 271848006128 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 271848006129 OpgC protein; Region: OpgC_C; cl00792 271848006130 Predicted permeases [General function prediction only]; Region: RarD; COG2962 271848006131 Acylphosphatase; Region: Acylphosphatase; cl00551 271848006132 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 271848006133 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 271848006134 putative NADP binding site [chemical binding]; other site 271848006135 putative substrate binding site [chemical binding]; other site 271848006136 active site 271848006137 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 271848006138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848006139 active site 271848006140 LytB protein; Region: LYTB; cl00507 271848006141 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 271848006142 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 271848006143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848006144 FeS/SAM binding site; other site 271848006145 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 271848006146 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 271848006147 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848006148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006149 Helix-turn-helix domains; Region: HTH; cl00088 271848006150 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 271848006151 putative substrate binding pocket [chemical binding]; other site 271848006152 putative dimerization interface [polypeptide binding]; other site 271848006153 aminotransferase; Validated; Region: PRK07046 271848006154 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848006155 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848006156 catalytic residue [active] 271848006157 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 271848006158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848006159 sequence-specific DNA binding site [nucleotide binding]; other site 271848006160 salt bridge; other site 271848006161 Protein of unknown function (DUF466); Region: DUF466; cl01082 271848006162 carbon starvation protein A; Provisional; Region: PRK15015 271848006163 Carbon starvation protein CstA; Region: CstA; pfam02554 271848006164 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 271848006165 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848006166 Uncharacterized conserved protein [Function unknown]; Region: COG5476 271848006167 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 271848006168 MlrC C-terminus; Region: MlrC_C; pfam07171 271848006169 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006170 Helix-turn-helix domains; Region: HTH; cl00088 271848006171 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848006172 dimerization interface [polypeptide binding]; other site 271848006173 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848006174 GtrA-like protein; Region: GtrA; cl00971 271848006175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848006176 S-adenosylmethionine binding site [chemical binding]; other site 271848006177 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 271848006178 Ligand binding site; other site 271848006179 Putative Catalytic site; other site 271848006180 DXD motif; other site 271848006181 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 271848006182 Flp/Fap pilin component; Region: Flp_Fap; cl01585 271848006183 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 271848006184 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 271848006185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848006186 active site 271848006187 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 271848006188 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 271848006189 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848006190 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 271848006191 TadE-like protein; Region: TadE; cl10688 271848006192 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 271848006193 TadE-like protein; Region: TadE; cl10688 271848006194 TadE-like protein; Region: TadE; cl10688 271848006195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 271848006196 active site 271848006197 phosphorylation site [posttranslational modification] 271848006198 intermolecular recognition site; other site 271848006199 dimerization interface [polypeptide binding]; other site 271848006200 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 271848006201 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 271848006202 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 271848006203 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 271848006204 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 271848006205 ATP binding site [chemical binding]; other site 271848006206 Walker A motif; other site 271848006207 hexamer interface [polypeptide binding]; other site 271848006208 Walker B motif; other site 271848006209 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 271848006210 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848006211 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848006212 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848006213 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848006214 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848006215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848006216 putative DNA binding site [nucleotide binding]; other site 271848006217 putative Zn2+ binding site [ion binding]; other site 271848006218 AsnC family; Region: AsnC_trans_reg; pfam01037 271848006219 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 271848006220 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848006221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006222 homodimer interface [polypeptide binding]; other site 271848006223 catalytic residue [active] 271848006224 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 271848006225 homotrimer interaction site [polypeptide binding]; other site 271848006226 putative active site [active] 271848006227 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006228 trimer interface [polypeptide binding]; other site 271848006229 eyelet of channel; other site 271848006230 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 271848006231 Transcriptional regulators [Transcription]; Region: FadR; COG2186 271848006232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848006233 DNA-binding site [nucleotide binding]; DNA binding site 271848006234 FCD domain; Region: FCD; cl11656 271848006235 Uncharacterized conserved protein [Function unknown]; Region: COG5476 271848006236 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 271848006237 MlrC C-terminus; Region: MlrC_C; pfam07171 271848006238 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 271848006239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006240 putative substrate translocation pore; other site 271848006241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006242 Helix-turn-helix domains; Region: HTH; cl00088 271848006243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848006244 dimerization interface [polypeptide binding]; other site 271848006245 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 271848006246 MltA-interacting protein MipA; Region: MipA; cl01504 271848006247 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271848006248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848006249 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 271848006250 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 271848006251 active site 271848006252 non-prolyl cis peptide bond; other site 271848006253 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271848006254 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 271848006255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848006257 putative substrate translocation pore; other site 271848006258 Flavin Reductases; Region: FlaRed; cl00801 271848006259 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848006260 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 271848006261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848006262 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271848006263 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848006264 E3 interaction surface; other site 271848006265 lipoyl attachment site [posttranslational modification]; other site 271848006266 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 271848006267 e3 binding domain; Region: E3_binding; pfam02817 271848006268 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 271848006269 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 271848006270 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 271848006271 alpha subunit interface [polypeptide binding]; other site 271848006272 TPP binding site [chemical binding]; other site 271848006273 heterodimer interface [polypeptide binding]; other site 271848006274 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848006275 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 271848006276 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 271848006277 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 271848006278 tetramer interface [polypeptide binding]; other site 271848006279 TPP-binding site [chemical binding]; other site 271848006280 heterodimer interface [polypeptide binding]; other site 271848006281 phosphorylation loop region [posttranslational modification] 271848006282 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 271848006283 putative hydrophobic ligand binding site [chemical binding]; other site 271848006284 protein interface [polypeptide binding]; other site 271848006285 gate; other site 271848006286 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 271848006287 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 271848006288 hydrophobic ligand binding site; other site 271848006289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006290 Helix-turn-helix domains; Region: HTH; cl00088 271848006291 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 271848006292 substrate binding pocket [chemical binding]; other site 271848006293 dimerization interface [polypeptide binding]; other site 271848006294 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 271848006295 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848006296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 271848006297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848006298 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 271848006299 nucleophile elbow; other site 271848006300 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 271848006301 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 271848006302 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 271848006303 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 271848006304 active site 271848006305 dimer interface [polypeptide binding]; other site 271848006306 effector binding site; other site 271848006307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 271848006308 AAA domain; Region: AAA_33; pfam13671 271848006309 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 271848006310 hypothetical protein; Provisional; Region: PRK07877 271848006311 FMN binding site [chemical binding]; other site 271848006312 dimer interface [polypeptide binding]; other site 271848006313 Sulfate transporter family; Region: Sulfate_transp; cl15842 271848006314 high affinity sulphate transporter 1; Region: sulP; TIGR00815 271848006315 Sulfate transporter family; Region: Sulfate_transp; cl15842 271848006316 Sulfate transporter family; Region: Sulfate_transp; cl15842 271848006317 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 271848006318 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 271848006319 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 271848006320 putative FMN binding site [chemical binding]; other site 271848006321 NADPH bind site [chemical binding]; other site 271848006322 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 271848006323 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 271848006324 putative dimer interface [polypeptide binding]; other site 271848006325 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 271848006326 putative active site [active] 271848006327 putative metal binding site [ion binding]; other site 271848006328 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 271848006329 Transglycosylase; Region: Transgly; cl07896 271848006330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848006331 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 271848006332 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848006333 PAAR motif; Region: PAAR_motif; cl15808 271848006334 amidase; Provisional; Region: PRK08137 271848006335 Amidase; Region: Amidase; cl11426 271848006336 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 271848006337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 271848006338 Cache domain; Region: Cache_2; cl07034 271848006339 Histidine kinase; Region: HisKA_3; pfam07730 271848006340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848006341 ATP binding site [chemical binding]; other site 271848006342 Mg2+ binding site [ion binding]; other site 271848006343 G-X-G motif; other site 271848006344 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848006345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006346 active site 271848006347 phosphorylation site [posttranslational modification] 271848006348 intermolecular recognition site; other site 271848006349 dimerization interface [polypeptide binding]; other site 271848006350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848006351 DNA binding residues [nucleotide binding] 271848006352 dimerization interface [polypeptide binding]; other site 271848006353 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 271848006354 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 271848006355 PAS domain; Region: PAS_9; pfam13426 271848006356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848006357 putative active site [active] 271848006358 heme pocket [chemical binding]; other site 271848006359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848006360 metal binding site [ion binding]; metal-binding site 271848006361 active site 271848006362 I-site; other site 271848006363 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848006364 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 271848006365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848006366 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271848006367 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 271848006368 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 271848006369 FtsX-like permease family; Region: FtsX; cl15850 271848006370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848006371 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271848006372 Walker A/P-loop; other site 271848006373 ATP binding site [chemical binding]; other site 271848006374 Q-loop/lid; other site 271848006375 ABC transporter signature motif; other site 271848006376 Walker B; other site 271848006377 D-loop; other site 271848006378 H-loop/switch region; other site 271848006379 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 271848006380 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 271848006381 Cytochrome P450; Region: p450; pfam00067 271848006382 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848006383 putative NADP binding site [chemical binding]; other site 271848006384 active site 271848006385 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 271848006386 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 271848006387 putative NAD(P) binding site [chemical binding]; other site 271848006388 active site 271848006389 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848006390 active site 271848006391 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 271848006392 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 271848006393 active site 271848006394 active site 271848006395 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848006396 putative NADP binding site [chemical binding]; other site 271848006397 active site 271848006398 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848006399 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848006400 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848006401 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 271848006402 VacJ like lipoprotein; Region: VacJ; cl01073 271848006403 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848006404 hypothetical protein; Provisional; Region: PRK07483 271848006405 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848006406 inhibitor-cofactor binding pocket; inhibition site 271848006407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006408 catalytic residue [active] 271848006409 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 271848006410 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 271848006411 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 271848006412 Walker A/P-loop; other site 271848006413 ATP binding site [chemical binding]; other site 271848006414 Q-loop/lid; other site 271848006415 ABC transporter signature motif; other site 271848006416 Walker B; other site 271848006417 D-loop; other site 271848006418 H-loop/switch region; other site 271848006419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848006420 dimer interface [polypeptide binding]; other site 271848006421 conserved gate region; other site 271848006422 putative PBP binding loops; other site 271848006423 ABC-ATPase subunit interface; other site 271848006424 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848006425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848006426 substrate binding pocket [chemical binding]; other site 271848006427 membrane-bound complex binding site; other site 271848006428 hinge residues; other site 271848006429 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 271848006430 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 271848006431 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 271848006432 Active site cavity [active] 271848006433 catalytic acid [active] 271848006434 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 271848006435 active site lid residues [active] 271848006436 substrate binding pocket [chemical binding]; other site 271848006437 catalytic residues [active] 271848006438 substrate-Mg2+ binding site; other site 271848006439 aspartate-rich region 1; other site 271848006440 aspartate-rich region 2; other site 271848006441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848006442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848006443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848006444 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848006445 metal binding site [ion binding]; metal-binding site 271848006446 active site 271848006447 I-site; other site 271848006448 Response regulator receiver domain; Region: Response_reg; pfam00072 271848006449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006450 active site 271848006451 phosphorylation site [posttranslational modification] 271848006452 intermolecular recognition site; other site 271848006453 dimerization interface [polypeptide binding]; other site 271848006454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848006455 dimer interface [polypeptide binding]; other site 271848006456 phosphorylation site [posttranslational modification] 271848006457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848006458 ATP binding site [chemical binding]; other site 271848006459 Mg2+ binding site [ion binding]; other site 271848006460 G-X-G motif; other site 271848006461 Response regulator receiver domain; Region: Response_reg; pfam00072 271848006462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006463 active site 271848006464 phosphorylation site [posttranslational modification] 271848006465 intermolecular recognition site; other site 271848006466 dimerization interface [polypeptide binding]; other site 271848006467 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271848006468 RNA polymerase sigma factor; Provisional; Region: PRK12545 271848006469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848006470 Putative zinc-finger; Region: zf-HC2; cl15806 271848006471 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 271848006472 ArsC family; Region: ArsC; pfam03960 271848006473 catalytic residues [active] 271848006474 ParA-like protein; Provisional; Region: PHA02518 271848006475 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848006476 P-loop; other site 271848006477 Magnesium ion binding site [ion binding]; other site 271848006478 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 271848006479 ParB-like nuclease domain; Region: ParBc; cl02129 271848006480 Initiator Replication protein; Region: Rep_3; cl03080 271848006481 Burkholderia thailandensis E264 is an environmental isolate and the type strain of the species. It is available from the American Type Culture Collection, Mananass, VA. 271848006482 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 271848006483 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 271848006484 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 271848006485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848006486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848006487 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271848006488 IHF dimer interface [polypeptide binding]; other site 271848006489 IHF - DNA interface [nucleotide binding]; other site 271848006490 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 271848006491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848006492 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 271848006493 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271848006494 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848006495 catalytic residue [active] 271848006496 type II secretion system protein D; Region: type_II_gspD; TIGR02517 271848006497 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848006498 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848006499 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848006500 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 271848006501 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848006502 type II secretion system protein E; Region: type_II_gspE; TIGR02533 271848006503 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 271848006504 Walker A motif; other site 271848006505 ATP binding site [chemical binding]; other site 271848006506 Walker B motif; other site 271848006507 type II secretion system protein F; Region: GspF; TIGR02120 271848006508 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848006509 Ceramidase; Region: Ceramidase; pfam05875 271848006510 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848006511 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 271848006512 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 271848006513 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 271848006514 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 271848006515 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 271848006516 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 271848006517 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 271848006518 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 271848006519 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 271848006520 GspL periplasmic domain; Region: GspL_C; cl14909 271848006521 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 271848006522 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 271848006523 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848006524 Helix-turn-helix domains; Region: HTH; cl00088 271848006525 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848006526 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848006527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006528 putative substrate translocation pore; other site 271848006529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006531 Helix-turn-helix domains; Region: HTH; cl00088 271848006532 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 271848006533 putative dimerization interface [polypeptide binding]; other site 271848006534 LrgA family; Region: LrgA; cl00608 271848006535 LrgB-like family; Region: LrgB; cl00596 271848006536 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 271848006537 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 271848006538 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271848006539 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271848006540 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 271848006541 FliP family; Region: FliP; cl00593 271848006542 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 271848006543 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 271848006544 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 271848006545 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 271848006546 DNA binding residues [nucleotide binding] 271848006547 putative dimer interface [polypeptide binding]; other site 271848006548 putative metal binding residues [ion binding]; other site 271848006549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848006550 NMT1-like family; Region: NMT1_2; cl15260 271848006551 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271848006552 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 271848006553 Walker A/P-loop; other site 271848006554 ATP binding site [chemical binding]; other site 271848006555 Q-loop/lid; other site 271848006556 ABC transporter signature motif; other site 271848006557 Walker B; other site 271848006558 D-loop; other site 271848006559 H-loop/switch region; other site 271848006560 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 271848006561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848006562 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271848006563 sensor protein QseC; Provisional; Region: PRK10337 271848006564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271848006565 dimer interface [polypeptide binding]; other site 271848006566 phosphorylation site [posttranslational modification] 271848006567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848006568 ATP binding site [chemical binding]; other site 271848006569 Mg2+ binding site [ion binding]; other site 271848006570 G-X-G motif; other site 271848006571 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 271848006572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006573 active site 271848006574 phosphorylation site [posttranslational modification] 271848006575 intermolecular recognition site; other site 271848006576 dimerization interface [polypeptide binding]; other site 271848006577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848006578 DNA binding site [nucleotide binding] 271848006579 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006580 trimer interface [polypeptide binding]; other site 271848006581 eyelet of channel; other site 271848006582 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 271848006583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848006584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848006585 Restriction endonuclease [Defense mechanisms]; Region: COG3587 271848006586 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848006587 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006588 trimer interface [polypeptide binding]; other site 271848006589 eyelet of channel; other site 271848006590 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 271848006591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848006592 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848006593 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271848006594 Walker A/P-loop; other site 271848006595 ATP binding site [chemical binding]; other site 271848006596 Q-loop/lid; other site 271848006597 ABC transporter signature motif; other site 271848006598 Walker B; other site 271848006599 D-loop; other site 271848006600 H-loop/switch region; other site 271848006601 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848006602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848006603 Walker A/P-loop; other site 271848006604 ATP binding site [chemical binding]; other site 271848006605 Q-loop/lid; other site 271848006606 ABC transporter signature motif; other site 271848006607 Walker B; other site 271848006608 D-loop; other site 271848006609 H-loop/switch region; other site 271848006610 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848006611 TM-ABC transporter signature motif; other site 271848006612 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848006613 TM-ABC transporter signature motif; other site 271848006614 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271848006615 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 271848006616 putative ligand binding site [chemical binding]; other site 271848006617 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848006618 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848006619 NAD(P) binding site [chemical binding]; other site 271848006620 catalytic residues [active] 271848006621 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848006622 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 271848006623 classical (c) SDRs; Region: SDR_c; cd05233 271848006624 NAD(P) binding site [chemical binding]; other site 271848006625 active site 271848006626 choline dehydrogenase; Validated; Region: PRK02106 271848006627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848006628 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848006629 Helix-turn-helix domains; Region: HTH; cl00088 271848006630 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 271848006631 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 271848006632 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848006633 putative di-iron ligands [ion binding]; other site 271848006634 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 271848006635 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 271848006636 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848006637 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 271848006638 conserved cys residue [active] 271848006639 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848006640 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848006641 active site 271848006642 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 271848006643 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848006644 dimer interface [polypeptide binding]; other site 271848006645 active site 271848006646 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 271848006647 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848006648 substrate binding site [chemical binding]; other site 271848006649 oxyanion hole (OAH) forming residues; other site 271848006650 trimer interface [polypeptide binding]; other site 271848006651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848006652 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848006653 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848006654 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848006655 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 271848006656 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 271848006657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848006658 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848006659 DNA binding residues [nucleotide binding] 271848006660 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 271848006661 putative heme binding pocket [chemical binding]; other site 271848006662 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271848006663 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 271848006664 catalytic residues [active] 271848006665 catalytic nucleophile [active] 271848006666 Recombinase; Region: Recombinase; pfam07508 271848006667 ParB-like nuclease domain; Region: ParBc; cl02129 271848006668 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 271848006669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848006670 Helix-turn-helix domains; Region: HTH; cl00088 271848006671 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 271848006672 transport protein sec23; Provisional; Region: PLN00162 271848006673 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 271848006674 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848006675 YaeQ protein; Region: YaeQ; cl01913 271848006676 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 271848006677 dimer interface [polypeptide binding]; other site 271848006678 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848006679 metal binding site [ion binding]; metal-binding site 271848006680 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 271848006681 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 271848006682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848006683 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 271848006684 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 271848006685 DNA binding site [nucleotide binding] 271848006686 active site 271848006687 AlkA N-terminal domain; Region: AlkA_N; cl05528 271848006688 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 271848006689 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271848006690 minor groove reading motif; other site 271848006691 helix-hairpin-helix signature motif; other site 271848006692 substrate binding pocket [chemical binding]; other site 271848006693 active site 271848006694 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 271848006695 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271848006696 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 271848006697 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848006698 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271848006699 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848006700 DNA binding residues [nucleotide binding] 271848006701 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 271848006702 dimer interface [polypeptide binding]; other site 271848006703 Phage-related protein [Function unknown]; Region: COG4695; cl01923 271848006704 Phage-related protein [Function unknown]; Region: COG4695; cl01923 271848006705 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848006706 active site 271848006707 DNA binding site [nucleotide binding] 271848006708 Int/Topo IB signature motif; other site 271848006709 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271848006710 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848006711 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848006712 Magnesium ion binding site [ion binding]; other site 271848006713 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848006714 active site 271848006715 DNA binding site [nucleotide binding] 271848006716 Int/Topo IB signature motif; other site 271848006717 DNA topoisomerase 2; Provisional; Region: PLN03237 271848006718 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 271848006719 Family description; Region: UvrD_C_2; cl15862 271848006720 Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396 271848006721 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 271848006722 putative homodimer interface [polypeptide binding]; other site 271848006723 putative active site [active] 271848006724 catalytic site [active] 271848006725 DEAD-like helicases superfamily; Region: DEXDc; smart00487 271848006726 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848006727 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848006728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 271848006729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848006730 non-specific DNA binding site [nucleotide binding]; other site 271848006731 salt bridge; other site 271848006732 sequence-specific DNA binding site [nucleotide binding]; other site 271848006733 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 271848006734 Domain of unknown function (DUF932); Region: DUF932; cl12129 271848006735 Predicted transcriptional regulator [Transcription]; Region: COG2378 271848006736 WYL domain; Region: WYL; cl14852 271848006737 Restriction endonuclease; Region: Mrr_cat; cl00516 271848006738 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271848006739 active site 271848006740 ATP binding site [chemical binding]; other site 271848006741 substrate binding site [chemical binding]; other site 271848006742 activation loop (A-loop); other site 271848006743 Protein kinase domain; Region: Pkinase; pfam00069 271848006744 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848006745 active site 271848006746 ATP binding site [chemical binding]; other site 271848006747 substrate binding site [chemical binding]; other site 271848006748 activation loop (A-loop); other site 271848006749 PglZ domain; Region: PglZ; pfam08665 271848006750 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 271848006751 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 271848006752 PAAR motif; Region: PAAR_motif; cl15808 271848006753 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848006754 CoenzymeA binding site [chemical binding]; other site 271848006755 subunit interaction site [polypeptide binding]; other site 271848006756 PHB binding site; other site 271848006757 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 271848006758 active site 271848006759 nucleophile elbow; other site 271848006760 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 271848006761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848006762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006763 Helix-turn-helix domains; Region: HTH; cl00088 271848006764 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848006765 putative effector binding pocket; other site 271848006766 dimerization interface [polypeptide binding]; other site 271848006767 DNA topoisomerase III; Validated; Region: PRK08173 271848006768 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 271848006769 active site 271848006770 putative interdomain interaction site [polypeptide binding]; other site 271848006771 putative metal-binding site [ion binding]; other site 271848006772 putative nucleotide binding site [chemical binding]; other site 271848006773 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 271848006774 domain I; other site 271848006775 DNA binding groove [nucleotide binding] 271848006776 phosphate binding site [ion binding]; other site 271848006777 domain II; other site 271848006778 domain III; other site 271848006779 nucleotide binding site [chemical binding]; other site 271848006780 catalytic site [active] 271848006781 domain IV; other site 271848006782 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 271848006783 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 271848006784 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848006785 catalytic residues [active] 271848006786 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271848006787 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 271848006788 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 271848006789 active site 271848006790 catalytic residues [active] 271848006791 metal binding site [ion binding]; metal-binding site 271848006792 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 271848006793 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 271848006794 putative active site [active] 271848006795 substrate binding site [chemical binding]; other site 271848006796 putative cosubstrate binding site; other site 271848006797 catalytic site [active] 271848006798 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 271848006799 substrate binding site [chemical binding]; other site 271848006800 LysE type translocator; Region: LysE; cl00565 271848006801 Peptidase family M48; Region: Peptidase_M48; cl12018 271848006802 16S rRNA methyltransferase B; Provisional; Region: PRK10901 271848006803 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 271848006804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848006805 S-adenosylmethionine binding site [chemical binding]; other site 271848006806 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 271848006807 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 271848006808 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848006809 dimerization interface [polypeptide binding]; other site 271848006810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848006811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848006812 dimer interface [polypeptide binding]; other site 271848006813 phosphorylation site [posttranslational modification] 271848006814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848006815 ATP binding site [chemical binding]; other site 271848006816 Mg2+ binding site [ion binding]; other site 271848006817 G-X-G motif; other site 271848006818 Response regulator receiver domain; Region: Response_reg; pfam00072 271848006819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006820 active site 271848006821 phosphorylation site [posttranslational modification] 271848006822 intermolecular recognition site; other site 271848006823 dimerization interface [polypeptide binding]; other site 271848006824 Helix-turn-helix domains; Region: HTH; cl00088 271848006825 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 271848006826 Ligand Binding Site [chemical binding]; other site 271848006827 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 271848006828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 271848006829 FeS/SAM binding site; other site 271848006830 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271848006831 active site 271848006832 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 271848006833 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848006834 Sel1 repeat; Region: Sel1; cl02723 271848006835 Sel1 repeat; Region: Sel1; cl02723 271848006836 Sel1 repeat; Region: Sel1; cl02723 271848006837 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 271848006838 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 271848006839 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 271848006840 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848006841 rod shape-determining protein MreD; Region: MreD; cl01087 271848006842 rod shape-determining protein MreC; Provisional; Region: PRK13922 271848006843 rod shape-determining protein MreC; Region: MreC; pfam04085 271848006844 rod shape-determining protein MreB; Provisional; Region: PRK13927 271848006845 Cell division protein FtsA; Region: FtsA; cl11496 271848006846 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 271848006847 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271848006848 Amidase; Region: Amidase; cl11426 271848006849 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 271848006850 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 271848006851 GatB domain; Region: GatB_Yqey; cl11497 271848006852 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 271848006853 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 271848006854 putative active site [active] 271848006855 putative catalytic site [active] 271848006856 putative DNA binding site [nucleotide binding]; other site 271848006857 putative phosphate binding site [ion binding]; other site 271848006858 metal binding site A [ion binding]; metal-binding site 271848006859 putative AP binding site [nucleotide binding]; other site 271848006860 putative metal binding site B [ion binding]; other site 271848006861 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 271848006862 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 271848006863 putative NAD(P) binding site [chemical binding]; other site 271848006864 putative substrate binding site [chemical binding]; other site 271848006865 catalytic Zn binding site [ion binding]; other site 271848006866 structural Zn binding site [ion binding]; other site 271848006867 dimer interface [polypeptide binding]; other site 271848006868 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 271848006869 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848006870 Peptidase family M48; Region: Peptidase_M48; cl12018 271848006871 muropeptide transporter; Reviewed; Region: ampG; PRK11902 271848006872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006873 putative substrate translocation pore; other site 271848006874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848006875 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848006876 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 271848006877 division inhibitor protein; Provisional; Region: slmA; PRK09480 271848006878 Helix-turn-helix domains; Region: HTH; cl00088 271848006879 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848006880 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 271848006881 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 271848006882 feedback inhibition sensing region; other site 271848006883 homohexameric interface [polypeptide binding]; other site 271848006884 nucleotide binding site [chemical binding]; other site 271848006885 N-acetyl-L-glutamate binding site [chemical binding]; other site 271848006886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848006887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271848006888 dimer interface [polypeptide binding]; other site 271848006889 phosphorylation site [posttranslational modification] 271848006890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848006891 ATP binding site [chemical binding]; other site 271848006892 Mg2+ binding site [ion binding]; other site 271848006893 G-X-G motif; other site 271848006894 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 271848006895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006896 active site 271848006897 phosphorylation site [posttranslational modification] 271848006898 intermolecular recognition site; other site 271848006899 dimerization interface [polypeptide binding]; other site 271848006900 Helix-turn-helix domains; Region: HTH; cl00088 271848006901 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 271848006902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848006903 Walker A motif; other site 271848006904 ATP binding site [chemical binding]; other site 271848006905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848006906 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848006907 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 271848006908 active site 271848006909 HslU subunit interaction site [polypeptide binding]; other site 271848006910 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 271848006911 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 271848006912 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 271848006913 P-loop, Walker A motif; other site 271848006914 Base recognition motif; other site 271848006915 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 271848006916 PUA domain; Region: PUA; cl00607 271848006917 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 271848006918 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 271848006919 putative RNA binding site [nucleotide binding]; other site 271848006920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848006921 S-adenosylmethionine binding site [chemical binding]; other site 271848006922 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 271848006923 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848006924 active site 271848006925 DNA binding site [nucleotide binding] 271848006926 Int/Topo IB signature motif; other site 271848006927 GAF domain; Region: GAF; cl15785 271848006928 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 271848006929 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 271848006930 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 271848006931 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 271848006932 putative acyl-acceptor binding pocket; other site 271848006933 S-adenosylmethionine synthetase; Validated; Region: PRK05250 271848006934 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 271848006935 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 271848006936 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 271848006937 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 271848006938 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 271848006939 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848006940 active site 271848006941 catalytic tetrad [active] 271848006942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006943 putative substrate translocation pore; other site 271848006944 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848006945 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848006946 Helix-turn-helix domains; Region: HTH; cl00088 271848006947 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 271848006948 putative dimerization interface [polypeptide binding]; other site 271848006949 putative substrate binding pocket [chemical binding]; other site 271848006950 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 271848006951 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848006952 putative active site [active] 271848006953 catalytic residue [active] 271848006954 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848006955 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 271848006956 dimer interface [polypeptide binding]; other site 271848006957 NADP binding site [chemical binding]; other site 271848006958 catalytic residues [active] 271848006959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006960 D-galactonate transporter; Region: 2A0114; TIGR00893 271848006961 putative substrate translocation pore; other site 271848006962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006963 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271848006964 substrate binding pocket [chemical binding]; other site 271848006965 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 271848006966 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 271848006967 active site 271848006968 tetramer interface [polypeptide binding]; other site 271848006969 galactarate dehydratase; Region: galactar-dH20; TIGR03248 271848006970 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 271848006971 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 271848006972 extended (e) SDRs; Region: SDR_e; cd08946 271848006973 NAD(P) binding site [chemical binding]; other site 271848006974 active site 271848006975 substrate binding site [chemical binding]; other site 271848006976 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 271848006977 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 271848006978 NAD(P) binding site [chemical binding]; other site 271848006979 catalytic residues [active] 271848006980 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 271848006981 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848006982 active site 271848006983 choline dehydrogenase; Validated; Region: PRK02106 271848006984 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848006985 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 271848006986 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 271848006987 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 271848006988 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 271848006989 Walker A motif/ATP binding site; other site 271848006990 Walker B motif; other site 271848006991 Flagellar assembly protein FliH; Region: FliH; pfam02108 271848006992 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 271848006993 FliG C-terminal domain; Region: FliG_C; pfam01706 271848006994 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 271848006995 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 271848006996 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 271848006997 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 271848006998 Flagellar protein FliS; Region: FliS; cl00654 271848006999 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 271848007000 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271848007001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 271848007002 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 271848007003 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 271848007004 XdhC Rossmann domain; Region: XdhC_C; pfam13478 271848007005 amino acid transporter; Region: 2A0306; TIGR00909 271848007006 Spore germination protein; Region: Spore_permease; cl15802 271848007007 Spore germination protein; Region: Spore_permease; cl15802 271848007008 response regulator; Provisional; Region: PRK09483 271848007009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848007010 active site 271848007011 phosphorylation site [posttranslational modification] 271848007012 intermolecular recognition site; other site 271848007013 dimerization interface [polypeptide binding]; other site 271848007014 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848007015 DNA binding residues [nucleotide binding] 271848007016 dimerization interface [polypeptide binding]; other site 271848007017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 271848007018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848007019 ATP binding site [chemical binding]; other site 271848007020 G-X-G motif; other site 271848007021 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 271848007022 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 271848007023 FAD binding pocket [chemical binding]; other site 271848007024 FAD binding motif [chemical binding]; other site 271848007025 phosphate binding motif [ion binding]; other site 271848007026 beta-alpha-beta structure motif; other site 271848007027 NAD binding pocket [chemical binding]; other site 271848007028 LysE type translocator; Region: LysE; cl00565 271848007029 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 271848007030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848007031 Walker A motif; other site 271848007032 ATP binding site [chemical binding]; other site 271848007033 Walker B motif; other site 271848007034 arginine finger; other site 271848007035 Predicted dehydrogenase [General function prediction only]; Region: COG0579 271848007036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007037 High potential iron-sulfur protein; Region: HIPIP; pfam01355 271848007038 citrate-proton symporter; Provisional; Region: PRK15075 271848007039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007040 putative substrate translocation pore; other site 271848007041 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 271848007042 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 271848007043 peptide binding site [polypeptide binding]; other site 271848007044 dipeptide transporter permease DppB; Provisional; Region: PRK10914 271848007045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848007046 dimer interface [polypeptide binding]; other site 271848007047 conserved gate region; other site 271848007048 putative PBP binding loops; other site 271848007049 ABC-ATPase subunit interface; other site 271848007050 dipeptide transporter; Provisional; Region: PRK10913 271848007051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848007052 dimer interface [polypeptide binding]; other site 271848007053 conserved gate region; other site 271848007054 putative PBP binding loops; other site 271848007055 ABC-ATPase subunit interface; other site 271848007056 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 271848007057 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848007058 Walker A/P-loop; other site 271848007059 ATP binding site [chemical binding]; other site 271848007060 Q-loop/lid; other site 271848007061 ABC transporter signature motif; other site 271848007062 Walker B; other site 271848007063 D-loop; other site 271848007064 H-loop/switch region; other site 271848007065 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848007066 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 271848007067 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848007068 Walker A/P-loop; other site 271848007069 ATP binding site [chemical binding]; other site 271848007070 Q-loop/lid; other site 271848007071 ABC transporter signature motif; other site 271848007072 Walker B; other site 271848007073 D-loop; other site 271848007074 H-loop/switch region; other site 271848007075 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848007076 TraB family; Region: TraB; cl12050 271848007077 Protein of unknown function (DUF979); Region: DUF979; cl01572 271848007078 Protein of unknown function (DUF969); Region: DUF969; cl01573 271848007079 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 271848007080 putative active site [active] 271848007081 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 271848007082 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 271848007083 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 271848007084 Helix-turn-helix domains; Region: HTH; cl00088 271848007085 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 271848007086 lytic murein transglycosylase; Provisional; Region: PRK11619 271848007087 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271848007088 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848007089 catalytic residue [active] 271848007090 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 271848007091 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 271848007092 putative NAD(P) binding site [chemical binding]; other site 271848007093 active site 271848007094 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 271848007095 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848007096 putative C-terminal domain interface [polypeptide binding]; other site 271848007097 putative GSH binding site (G-site) [chemical binding]; other site 271848007098 putative dimer interface [polypeptide binding]; other site 271848007099 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 271848007100 putative N-terminal domain interface [polypeptide binding]; other site 271848007101 putative dimer interface [polypeptide binding]; other site 271848007102 putative substrate binding pocket (H-site) [chemical binding]; other site 271848007103 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 271848007104 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 271848007105 active site 271848007106 NTP binding site [chemical binding]; other site 271848007107 metal binding triad [ion binding]; metal-binding site 271848007108 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 271848007109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271848007110 FlgN protein; Region: FlgN; cl09176 271848007111 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 271848007112 SAF-like; Region: SAF_2; pfam13144 271848007113 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 271848007114 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 271848007115 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848007116 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 271848007117 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848007118 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848007119 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 271848007120 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 271848007121 FlgD Ig-like domain; Region: FlgD_ig; cl15790 271848007122 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 271848007123 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848007124 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 271848007125 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848007126 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 271848007127 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848007128 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848007129 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 271848007130 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 271848007131 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848007132 Flagellar L-ring protein; Region: FlgH; cl00905 271848007133 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 271848007134 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 271848007135 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 271848007136 Rod binding protein; Region: Rod-binding; cl01626 271848007137 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 271848007138 Flagellar regulator YcgR; Region: YcgR; pfam07317 271848007139 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 271848007140 PilZ domain; Region: PilZ; cl01260 271848007141 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 271848007142 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 271848007143 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 271848007144 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271848007145 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 271848007146 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848007147 Helix-turn-helix domains; Region: HTH; cl00088 271848007148 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848007149 dimerization interface [polypeptide binding]; other site 271848007150 substrate binding pocket [chemical binding]; other site 271848007151 Chromate transporter; Region: Chromate_transp; pfam02417 271848007152 Chromate transporter; Region: Chromate_transp; pfam02417 271848007153 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 271848007154 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 271848007155 PhnA protein; Region: PhnA; pfam03831 271848007156 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 271848007157 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848007158 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848007159 trimer interface [polypeptide binding]; other site 271848007160 eyelet of channel; other site 271848007161 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 271848007162 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 271848007163 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 271848007164 ligand binding site; other site 271848007165 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848007166 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848007167 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 271848007168 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 271848007169 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 271848007170 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 271848007171 glutathione reductase; Validated; Region: PRK06116 271848007172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848007173 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271848007174 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848007175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848007176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848007177 active site 271848007178 phosphorylation site [posttranslational modification] 271848007179 intermolecular recognition site; other site 271848007180 dimerization interface [polypeptide binding]; other site 271848007181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848007182 DNA binding site [nucleotide binding] 271848007183 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 271848007184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848007185 dimerization interface [polypeptide binding]; other site 271848007186 Helix-turn-helix domains; Region: HTH; cl00088 271848007187 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848007188 putative effector binding pocket; other site 271848007189 dimerization interface [polypeptide binding]; other site 271848007190 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 271848007191 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 271848007192 Ligand Binding Site [chemical binding]; other site 271848007193 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271848007194 metal-binding site [ion binding] 271848007195 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 271848007196 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271848007197 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848007198 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848007199 LemA family; Region: LemA; cl00742 271848007200 Repair protein; Region: Repair_PSII; cl01535 271848007201 Repair protein; Region: Repair_PSII; cl01535 271848007202 Avidin family; Region: Avidin; pfam01382 271848007203 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 271848007204 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 271848007205 glutaminase active site [active] 271848007206 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 271848007207 dimer interface [polypeptide binding]; other site 271848007208 active site 271848007209 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 271848007210 dimer interface [polypeptide binding]; other site 271848007211 active site 271848007212 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 271848007213 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 271848007214 Substrate binding site; other site 271848007215 Mg++ binding site; other site 271848007216 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 271848007217 active site 271848007218 substrate binding site [chemical binding]; other site 271848007219 CoA binding site [chemical binding]; other site 271848007220 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 271848007221 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 271848007222 Ligand Binding Site [chemical binding]; other site 271848007223 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271848007224 active site 271848007225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007226 active site 271848007227 Uncharacterized conserved protein [Function unknown]; Region: COG1565 271848007228 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 271848007229 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 271848007230 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 271848007231 putative substrate binding site [chemical binding]; other site 271848007232 putative ATP binding site [chemical binding]; other site 271848007233 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 271848007234 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 271848007235 dimerization interface [polypeptide binding]; other site 271848007236 putative active cleft [active] 271848007237 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848007238 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848007239 DNA binding site [nucleotide binding] 271848007240 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 271848007241 ligand binding site [chemical binding]; other site 271848007242 dimerization interface [polypeptide binding]; other site 271848007243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848007244 dimer interface [polypeptide binding]; other site 271848007245 putative CheW interface [polypeptide binding]; other site 271848007246 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 271848007247 Membrane transport protein; Region: Mem_trans; cl09117 271848007248 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848007249 trimer interface [polypeptide binding]; other site 271848007250 eyelet of channel; other site 271848007251 Helix-turn-helix domains; Region: HTH; cl00088 271848007252 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848007253 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848007254 putative effector binding pocket; other site 271848007255 dimerization interface [polypeptide binding]; other site 271848007256 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 271848007257 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 271848007258 FMN binding site [chemical binding]; other site 271848007259 substrate binding site [chemical binding]; other site 271848007260 putative catalytic residue [active] 271848007261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848007262 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848007263 Helix-turn-helix domains; Region: HTH; cl00088 271848007264 AsnC family; Region: AsnC_trans_reg; pfam01037 271848007265 EamA-like transporter family; Region: EamA; cl01037 271848007266 EamA-like transporter family; Region: EamA; cl01037 271848007267 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 271848007268 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 271848007269 putative deacylase active site [active] 271848007270 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 271848007271 active site 271848007272 catalytic residues [active] 271848007273 metal binding site [ion binding]; metal-binding site 271848007274 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 271848007275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007276 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 271848007277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848007278 putative metal binding site [ion binding]; other site 271848007279 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848007280 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 271848007281 Phosphoesterase family; Region: Phosphoesterase; cl15450 271848007282 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848007283 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848007284 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848007285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848007286 putative DNA binding site [nucleotide binding]; other site 271848007287 putative Zn2+ binding site [ion binding]; other site 271848007288 AsnC family; Region: AsnC_trans_reg; pfam01037 271848007289 AzlC protein; Region: AzlC; cl00570 271848007290 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 271848007291 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848007292 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848007293 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 271848007294 dimer interface [polypeptide binding]; other site 271848007295 active site 271848007296 catalytic residue [active] 271848007297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848007298 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271848007299 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 271848007300 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 271848007301 Ion channel; Region: Ion_trans_2; cl11596 271848007302 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 271848007303 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 271848007304 dimer interface [polypeptide binding]; other site 271848007305 PYR/PP interface [polypeptide binding]; other site 271848007306 TPP binding site [chemical binding]; other site 271848007307 substrate binding site [chemical binding]; other site 271848007308 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 271848007309 TPP-binding site; other site 271848007310 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 271848007311 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 271848007312 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271848007313 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 271848007314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848007315 glycoprotein BALF4; Provisional; Region: PHA03231 271848007316 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 271848007317 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 271848007318 active site 271848007319 dimer interface [polypeptide binding]; other site 271848007320 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 271848007321 Alkaline phosphatase homologues; Region: alkPPc; smart00098 271848007322 active site 271848007323 dimer interface [polypeptide binding]; other site 271848007324 CutC family; Region: CutC; cl01218 271848007325 biotin synthase; Region: bioB; TIGR00433 271848007326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848007327 FeS/SAM binding site; other site 271848007328 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 271848007329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848007330 AAA domain; Region: AAA_26; pfam13500 271848007331 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 271848007332 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848007333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848007334 catalytic residue [active] 271848007335 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 271848007336 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848007337 inhibitor-cofactor binding pocket; inhibition site 271848007338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848007339 catalytic residue [active] 271848007340 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 271848007341 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848007342 hypothetical protein; Provisional; Region: PRK01842 271848007343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007344 NAD(P) binding site [chemical binding]; other site 271848007345 active site 271848007346 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 271848007347 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848007348 dimer interface [polypeptide binding]; other site 271848007349 active site 271848007350 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 271848007351 active site clefts [active] 271848007352 zinc binding site [ion binding]; other site 271848007353 dimer interface [polypeptide binding]; other site 271848007354 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 271848007355 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 271848007356 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848007357 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 271848007358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848007359 Walker A/P-loop; other site 271848007360 ATP binding site [chemical binding]; other site 271848007361 Q-loop/lid; other site 271848007362 ABC transporter signature motif; other site 271848007363 Walker B; other site 271848007364 D-loop; other site 271848007365 H-loop/switch region; other site 271848007366 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271848007367 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 271848007368 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 271848007369 peptide binding site [polypeptide binding]; other site 271848007370 Helix-turn-helix domains; Region: HTH; cl00088 271848007371 Transcriptional regulators [Transcription]; Region: MarR; COG1846 271848007372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007373 NAD(P) binding site [chemical binding]; other site 271848007374 active site 271848007375 short chain dehydrogenase; Provisional; Region: PRK08251 271848007376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007377 NAD(P) binding site [chemical binding]; other site 271848007378 active site 271848007379 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 271848007380 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 271848007381 catalytic residues [active] 271848007382 hinge region; other site 271848007383 alpha helical domain; other site 271848007384 Sporulation related domain; Region: SPOR; cl10051 271848007385 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 271848007386 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 271848007387 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 271848007388 active site 271848007389 HIGH motif; other site 271848007390 KMSK motif region; other site 271848007391 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 271848007392 tRNA binding surface [nucleotide binding]; other site 271848007393 anticodon binding site; other site 271848007394 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 271848007395 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 271848007396 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 271848007397 substrate binding pocket [chemical binding]; other site 271848007398 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 271848007399 B12 binding site [chemical binding]; other site 271848007400 cobalt ligand [ion binding]; other site 271848007401 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 271848007402 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 271848007403 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 271848007404 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 271848007405 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 271848007406 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848007407 Helix-turn-helix domains; Region: HTH; cl00088 271848007408 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 271848007409 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848007410 enoyl-CoA hydratase; Provisional; Region: PRK07657 271848007411 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848007412 substrate binding site [chemical binding]; other site 271848007413 oxyanion hole (OAH) forming residues; other site 271848007414 trimer interface [polypeptide binding]; other site 271848007415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 271848007416 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 271848007417 active site 271848007418 nucleophile elbow; other site 271848007419 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 271848007420 dinuclear metal binding motif [ion binding]; other site 271848007421 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848007422 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 271848007423 active site 271848007424 HIGH motif; other site 271848007425 nucleotide binding site [chemical binding]; other site 271848007426 Type III pantothenate kinase; Region: Pan_kinase; cl09130 271848007427 biotin--protein ligase; Provisional; Region: PRK06955 271848007428 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 271848007429 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 271848007430 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271848007431 Sel1 repeat; Region: Sel1; cl02723 271848007432 Sel1 repeat; Region: Sel1; cl02723 271848007433 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 271848007434 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 271848007435 active site 271848007436 metal binding site [ion binding]; metal-binding site 271848007437 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 271848007438 Permease; Region: Permease; cl00510 271848007439 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 271848007440 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 271848007441 Walker A/P-loop; other site 271848007442 ATP binding site [chemical binding]; other site 271848007443 Q-loop/lid; other site 271848007444 ABC transporter signature motif; other site 271848007445 Walker B; other site 271848007446 D-loop; other site 271848007447 H-loop/switch region; other site 271848007448 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 271848007449 mce related protein; Region: MCE; pfam02470 271848007450 Protein of unknown function (DUF330); Region: DUF330; cl01135 271848007451 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 271848007452 dimer interface [polypeptide binding]; other site 271848007453 [2Fe-2S] cluster binding site [ion binding]; other site 271848007454 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 271848007455 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 271848007456 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848007457 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 271848007458 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 271848007459 homodimer interface [polypeptide binding]; other site 271848007460 substrate-cofactor binding pocket; other site 271848007461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848007462 catalytic residue [active] 271848007463 Protein of unknown function (DUF493); Region: DUF493; cl01102 271848007464 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848007465 Helix-turn-helix domains; Region: HTH; cl00088 271848007466 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848007467 dimerization interface [polypeptide binding]; other site 271848007468 substrate binding pocket [chemical binding]; other site 271848007469 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 271848007470 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 271848007471 lipoyl synthase; Provisional; Region: PRK05481 271848007472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848007473 FeS/SAM binding site; other site 271848007474 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 271848007475 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 271848007476 putative NAD(P) binding site [chemical binding]; other site 271848007477 Helix-turn-helix domains; Region: HTH; cl00088 271848007478 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 271848007479 putative effector binding pocket; other site 271848007480 putative dimerization interface [polypeptide binding]; other site 271848007481 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 271848007482 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 271848007483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848007484 Helix-turn-helix domains; Region: HTH; cl00088 271848007485 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848007486 putative effector binding pocket; other site 271848007487 dimerization interface [polypeptide binding]; other site 271848007488 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848007489 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 271848007490 substrate binding site [chemical binding]; other site 271848007491 oxyanion hole (OAH) forming residues; other site 271848007492 trimer interface [polypeptide binding]; other site 271848007493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007494 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848007495 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848007496 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 271848007497 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848007498 active site 271848007499 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 271848007500 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 271848007501 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271848007502 active site 271848007503 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848007504 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848007505 Protein of unknown function, DUF485; Region: DUF485; cl01231 271848007506 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 271848007507 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 271848007508 Na binding site [ion binding]; other site 271848007509 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 271848007510 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 271848007511 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 271848007512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848007513 dimer interface [polypeptide binding]; other site 271848007514 phosphorylation site [posttranslational modification] 271848007515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848007516 ATP binding site [chemical binding]; other site 271848007517 Mg2+ binding site [ion binding]; other site 271848007518 G-X-G motif; other site 271848007519 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848007520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848007521 active site 271848007522 phosphorylation site [posttranslational modification] 271848007523 intermolecular recognition site; other site 271848007524 dimerization interface [polypeptide binding]; other site 271848007525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848007526 Walker A motif; other site 271848007527 ATP binding site [chemical binding]; other site 271848007528 Walker B motif; other site 271848007529 arginine finger; other site 271848007530 Helix-turn-helix domains; Region: HTH; cl00088 271848007531 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271848007532 catalytic residues [active] 271848007533 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848007534 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 271848007535 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271848007536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848007537 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 271848007538 Membrane fusogenic activity; Region: BMFP; cl01115 271848007539 Nitrogen regulatory protein P-II; Region: P-II; cl00412 271848007540 Nitrogen regulatory protein P-II; Region: P-II; smart00938 271848007541 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 271848007542 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 271848007543 Glutamate-cysteine ligase; Region: GshA; pfam08886 271848007544 glutathione synthetase; Provisional; Region: PRK05246 271848007545 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 271848007546 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848007547 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 271848007548 active pocket/dimerization site; other site 271848007549 active site 271848007550 phosphorylation site [posttranslational modification] 271848007551 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 271848007552 dimerization domain swap beta strand [polypeptide binding]; other site 271848007553 regulatory protein interface [polypeptide binding]; other site 271848007554 active site 271848007555 regulatory phosphorylation site [posttranslational modification]; other site 271848007556 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 271848007557 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 271848007558 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 271848007559 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848007560 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 271848007561 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 271848007562 ATP binding site [chemical binding]; other site 271848007563 substrate interface [chemical binding]; other site 271848007564 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 271848007565 C-terminal peptidase (prc); Region: prc; TIGR00225 271848007566 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 271848007567 protein binding site [polypeptide binding]; other site 271848007568 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 271848007569 Catalytic dyad [active] 271848007570 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271848007571 catalytic core [active] 271848007572 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271848007573 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 271848007574 active site residue [active] 271848007575 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 271848007576 GSH binding site [chemical binding]; other site 271848007577 catalytic residues [active] 271848007578 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 271848007579 SecA binding site; other site 271848007580 Preprotein binding site; other site 271848007581 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 271848007582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007583 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 271848007584 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 271848007585 putative ADP-ribose binding site [chemical binding]; other site 271848007586 putative active site [active] 271848007587 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 271848007588 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 271848007589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848007590 active site 271848007591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848007592 S-adenosylmethionine binding site [chemical binding]; other site 271848007593 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 271848007594 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 271848007595 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 271848007596 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848007597 Cytochrome c; Region: Cytochrom_C; cl11414 271848007598 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848007599 ligand binding site [chemical binding]; other site 271848007600 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 271848007601 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 271848007602 Subunit I/III interface [polypeptide binding]; other site 271848007603 D-pathway; other site 271848007604 Subunit I/VIIc interface [polypeptide binding]; other site 271848007605 Subunit I/IV interface [polypeptide binding]; other site 271848007606 Subunit I/II interface [polypeptide binding]; other site 271848007607 Low-spin heme (heme a) binding site [chemical binding]; other site 271848007608 Subunit I/VIIa interface [polypeptide binding]; other site 271848007609 Subunit I/VIa interface [polypeptide binding]; other site 271848007610 Dimer interface; other site 271848007611 Putative water exit pathway; other site 271848007612 Binuclear center (heme a3/CuB) [ion binding]; other site 271848007613 K-pathway; other site 271848007614 Subunit I/Vb interface [polypeptide binding]; other site 271848007615 Putative proton exit pathway; other site 271848007616 Subunit I/VIb interface; other site 271848007617 Subunit I/VIc interface [polypeptide binding]; other site 271848007618 Electron transfer pathway; other site 271848007619 Subunit I/VIIIb interface [polypeptide binding]; other site 271848007620 Subunit I/VIIb interface [polypeptide binding]; other site 271848007621 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 271848007622 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 271848007623 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 271848007624 Subunit III/VIIa interface [polypeptide binding]; other site 271848007625 Phospholipid binding site [chemical binding]; other site 271848007626 Subunit I/III interface [polypeptide binding]; other site 271848007627 Subunit III/VIb interface [polypeptide binding]; other site 271848007628 Subunit III/VIa interface; other site 271848007629 Subunit III/Vb interface [polypeptide binding]; other site 271848007630 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 271848007631 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 271848007632 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 271848007633 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 271848007634 UbiA prenyltransferase family; Region: UbiA; cl00337 271848007635 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271848007636 Cu(I) binding site [ion binding]; other site 271848007637 YCII-related domain; Region: YCII; cl00999 271848007638 Cache domain; Region: Cache_2; cl07034 271848007639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848007640 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848007641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848007642 dimer interface [polypeptide binding]; other site 271848007643 putative CheW interface [polypeptide binding]; other site 271848007644 NMT1-like family; Region: NMT1_2; cl15260 271848007645 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 271848007646 zinc binding site [ion binding]; other site 271848007647 putative ligand binding site [chemical binding]; other site 271848007648 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 271848007649 TM-ABC transporter signature motif; other site 271848007650 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 271848007651 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848007652 Walker A/P-loop; other site 271848007653 ATP binding site [chemical binding]; other site 271848007654 Q-loop/lid; other site 271848007655 ABC transporter signature motif; other site 271848007656 Walker B; other site 271848007657 D-loop; other site 271848007658 H-loop/switch region; other site 271848007659 DNA Polymerase Y-family; Region: PolY_like; cd03468 271848007660 active site 271848007661 DNA binding site [nucleotide binding] 271848007662 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 271848007663 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 271848007664 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 271848007665 generic binding surface II; other site 271848007666 generic binding surface I; other site 271848007667 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 271848007668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848007669 DNA-binding site [nucleotide binding]; DNA binding site 271848007670 UTRA domain; Region: UTRA; cl01230 271848007671 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 271848007672 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 271848007673 active site 271848007674 dimer interface [polypeptide binding]; other site 271848007675 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 271848007676 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 271848007677 dimer interface [polypeptide binding]; other site 271848007678 active site 271848007679 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 271848007680 dimer interface [polypeptide binding]; other site 271848007681 active site 271848007682 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 271848007683 HPr interaction site; other site 271848007684 glycerol kinase (GK) interaction site [polypeptide binding]; other site 271848007685 active site 271848007686 phosphorylation site [posttranslational modification] 271848007687 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 271848007688 dimerization domain swap beta strand [polypeptide binding]; other site 271848007689 regulatory protein interface [polypeptide binding]; other site 271848007690 active site 271848007691 regulatory phosphorylation site [posttranslational modification]; other site 271848007692 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 271848007693 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 271848007694 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 271848007695 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848007696 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 271848007697 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 271848007698 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 271848007699 active site turn [active] 271848007700 phosphorylation site [posttranslational modification] 271848007701 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 271848007702 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 271848007703 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 271848007704 active site 271848007705 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 271848007706 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 271848007707 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 271848007708 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 271848007709 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 271848007710 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 271848007711 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271848007712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848007713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848007714 DNA binding residues [nucleotide binding] 271848007715 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 271848007716 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848007717 2-isopropylmalate synthase; Validated; Region: PRK03739 271848007718 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 271848007719 active site 271848007720 catalytic residues [active] 271848007721 metal binding site [ion binding]; metal-binding site 271848007722 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848007723 glycosyl transferase family protein; Provisional; Region: PRK08136 271848007724 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271848007725 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848007726 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 271848007727 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 271848007728 molybdopterin cofactor binding site; other site 271848007729 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 271848007730 molybdopterin cofactor binding site; other site 271848007731 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 271848007732 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271848007733 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 271848007734 [2Fe-2S] cluster binding site [ion binding]; other site 271848007735 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 271848007736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848007737 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271848007738 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 271848007739 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848007740 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 271848007741 maleylacetoacetate isomerase; Region: maiA; TIGR01262 271848007742 C-terminal domain interface [polypeptide binding]; other site 271848007743 GSH binding site (G-site) [chemical binding]; other site 271848007744 putative dimer interface [polypeptide binding]; other site 271848007745 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 271848007746 dimer interface [polypeptide binding]; other site 271848007747 N-terminal domain interface [polypeptide binding]; other site 271848007748 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 271848007749 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 271848007750 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 271848007751 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 271848007752 P loop; other site 271848007753 GTP binding site [chemical binding]; other site 271848007754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848007755 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 271848007756 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 271848007757 active site 271848007758 (T/H)XGH motif; other site 271848007759 hypothetical protein; Provisional; Region: PRK13795 271848007760 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 271848007761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848007762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848007763 homodimer interface [polypeptide binding]; other site 271848007764 catalytic residue [active] 271848007765 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 271848007766 putative active site [active] 271848007767 catalytic residue [active] 271848007768 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 271848007769 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 271848007770 5S rRNA interface [nucleotide binding]; other site 271848007771 CTC domain interface [polypeptide binding]; other site 271848007772 L16 interface [polypeptide binding]; other site 271848007773 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 271848007774 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 271848007775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848007776 active site 271848007777 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 271848007778 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 271848007779 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 271848007780 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 271848007781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848007782 TPR motif; other site 271848007783 binding surface 271848007784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848007785 binding surface 271848007786 TPR motif; other site 271848007787 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 271848007788 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 271848007789 DNA binding site [nucleotide binding] 271848007790 catalytic residue [active] 271848007791 H2TH interface [polypeptide binding]; other site 271848007792 putative catalytic residues [active] 271848007793 turnover-facilitating residue; other site 271848007794 intercalation triad [nucleotide binding]; other site 271848007795 8OG recognition residue [nucleotide binding]; other site 271848007796 putative reading head residues; other site 271848007797 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 271848007798 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 271848007799 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 271848007800 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271848007801 minor groove reading motif; other site 271848007802 helix-hairpin-helix signature motif; other site 271848007803 substrate binding pocket [chemical binding]; other site 271848007804 active site 271848007805 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 271848007806 DNA binding and oxoG recognition site [nucleotide binding] 271848007807 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 271848007808 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 271848007809 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 271848007810 HPr kinase/phosphorylase; Provisional; Region: PRK05428 271848007811 DRTGG domain; Region: DRTGG; cl12147 271848007812 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 271848007813 Hpr binding site; other site 271848007814 active site 271848007815 homohexamer subunit interaction site [polypeptide binding]; other site 271848007816 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 271848007817 active site 271848007818 phosphorylation site [posttranslational modification] 271848007819 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 271848007820 30S subunit binding site; other site 271848007821 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 271848007822 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 271848007823 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 271848007824 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 271848007825 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 271848007826 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 271848007827 Walker A/P-loop; other site 271848007828 ATP binding site [chemical binding]; other site 271848007829 Q-loop/lid; other site 271848007830 ABC transporter signature motif; other site 271848007831 Walker B; other site 271848007832 D-loop; other site 271848007833 H-loop/switch region; other site 271848007834 OstA-like protein; Region: OstA; cl00844 271848007835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 271848007836 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 271848007837 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848007838 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 271848007839 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 271848007840 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 271848007841 putative active site [active] 271848007842 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 271848007843 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271848007844 putative cation:proton antiport protein; Provisional; Region: PRK10669 271848007845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007846 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271848007847 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848007848 active site 271848007849 LysE type translocator; Region: LysE; cl00565 271848007850 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 271848007851 nudix motif; other site 271848007852 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 271848007853 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 271848007854 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 271848007855 putative active site [active] 271848007856 putative substrate binding site [chemical binding]; other site 271848007857 putative cosubstrate binding site; other site 271848007858 catalytic site [active] 271848007859 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 271848007860 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 271848007861 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 271848007862 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 271848007863 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 271848007864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007865 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848007866 putative substrate translocation pore; other site 271848007867 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 271848007868 dimer interface [polypeptide binding]; other site 271848007869 ssDNA binding site [nucleotide binding]; other site 271848007870 tetramer (dimer of dimers) interface [polypeptide binding]; other site 271848007871 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 271848007872 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848007873 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848007874 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848007875 MULE transposase domain; Region: MULE; pfam10551 271848007876 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848007877 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 271848007878 virulence protein SpvB; Provisional; Region: PRK15244 271848007879 Family description; Region: VCBS; pfam13517 271848007880 Family description; Region: VCBS; pfam13517 271848007881 Family description; Region: VCBS; pfam13517 271848007882 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 271848007883 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 271848007884 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848007885 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 271848007886 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271848007887 phosphopeptide binding site; other site 271848007888 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848007889 active site 271848007890 ATP binding site [chemical binding]; other site 271848007891 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 271848007892 substrate binding site [chemical binding]; other site 271848007893 activation loop (A-loop); other site 271848007894 cyclase homology domain; Region: CHD; cd07302 271848007895 dimer interface [polypeptide binding]; other site 271848007896 nucleotidyl binding site; other site 271848007897 metal binding site [ion binding]; metal-binding site 271848007898 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848007899 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 271848007900 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 271848007901 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 271848007902 YcaO-like family; Region: YcaO; pfam02624 271848007903 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 271848007904 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 271848007905 intersubunit interface [polypeptide binding]; other site 271848007906 active site 271848007907 Zn2+ binding site [ion binding]; other site 271848007908 sensory histidine kinase AtoS; Provisional; Region: PRK11360 271848007909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848007910 metal binding site [ion binding]; metal-binding site 271848007911 active site 271848007912 I-site; other site 271848007913 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848007914 MatE; Region: MatE; cl10513 271848007915 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848007916 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 271848007917 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 271848007918 Substrate binding site; other site 271848007919 Cupin domain; Region: Cupin_2; cl09118 271848007920 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848007921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848007922 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 271848007923 putative ADP-binding pocket [chemical binding]; other site 271848007924 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 271848007925 active site 271848007926 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848007927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848007928 Walker A motif; other site 271848007929 ATP binding site [chemical binding]; other site 271848007930 Walker B motif; other site 271848007931 arginine finger; other site 271848007932 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 271848007933 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 271848007934 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 271848007935 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 271848007936 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 271848007937 dimer interface [polypeptide binding]; other site 271848007938 motif 1; other site 271848007939 active site 271848007940 motif 2; other site 271848007941 motif 3; other site 271848007942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848007943 active site 271848007944 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848007945 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848007946 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848007947 ligand binding site [chemical binding]; other site 271848007948 flexible hinge region; other site 271848007949 Helix-turn-helix domains; Region: HTH; cl00088 271848007950 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848007951 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 271848007952 Helix-turn-helix domains; Region: HTH; cl00088 271848007953 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 271848007954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007955 Bacterial sugar transferase; Region: Bac_transf; cl00939 271848007956 polysaccharide export protein Wza; Provisional; Region: PRK15078 271848007957 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848007958 SLBB domain; Region: SLBB; pfam10531 271848007959 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848007960 CHRD domain; Region: CHRD; cl06473 271848007961 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848007962 EcsC protein family; Region: EcsC; pfam12787 271848007963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848007965 putative substrate translocation pore; other site 271848007966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007967 Transcriptional regulators [Transcription]; Region: MarR; COG1846 271848007968 Helix-turn-helix domains; Region: HTH; cl00088 271848007969 intracellular protease, PfpI family; Region: PfpI; TIGR01382 271848007970 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 271848007971 conserved cys residue [active] 271848007972 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 271848007973 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 271848007974 dimer interface [polypeptide binding]; other site 271848007975 active site 271848007976 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848007977 substrate binding site [chemical binding]; other site 271848007978 catalytic residue [active] 271848007979 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848007980 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848007981 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848007982 putative active site [active] 271848007983 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 271848007984 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 271848007985 active site 271848007986 putative substrate binding pocket [chemical binding]; other site 271848007987 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 271848007988 homotrimer interaction site [polypeptide binding]; other site 271848007989 putative active site [active] 271848007990 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 271848007991 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271848007992 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 271848007993 threonine dehydratase; Reviewed; Region: PRK09224 271848007994 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271848007995 tetramer interface [polypeptide binding]; other site 271848007996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848007997 catalytic residue [active] 271848007998 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 271848007999 putative Ile/Val binding site [chemical binding]; other site 271848008000 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 271848008001 putative Ile/Val binding site [chemical binding]; other site 271848008002 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 271848008003 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848008004 FAD binding domain; Region: FAD_binding_4; pfam01565 271848008005 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 271848008006 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 271848008007 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 271848008008 Cysteine-rich domain; Region: CCG; pfam02754 271848008009 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 271848008010 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 271848008011 nucleotide binding site/active site [active] 271848008012 HIT family signature motif; other site 271848008013 catalytic residue [active] 271848008014 Protein of unknown function (DUF971); Region: DUF971; cl01414 271848008015 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 271848008016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848008017 S-adenosylmethionine binding site [chemical binding]; other site 271848008018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848008019 Tim44-like domain; Region: Tim44; cl09208 271848008020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 271848008021 SCP-2 sterol transfer family; Region: SCP2; cl01225 271848008022 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848008023 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 271848008024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848008025 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 271848008026 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 271848008027 Protein of unknown function (DUF502); Region: DUF502; cl01107 271848008028 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 271848008029 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 271848008030 dimer interface [polypeptide binding]; other site 271848008031 anticodon binding site; other site 271848008032 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 271848008033 homodimer interface [polypeptide binding]; other site 271848008034 motif 1; other site 271848008035 active site 271848008036 motif 2; other site 271848008037 GAD domain; Region: GAD; pfam02938 271848008038 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 271848008039 motif 3; other site 271848008040 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 271848008041 nudix motif; other site 271848008042 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 271848008043 PLD-like domain; Region: PLDc_2; pfam13091 271848008044 putative active site [active] 271848008045 catalytic site [active] 271848008046 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 271848008047 PLD-like domain; Region: PLDc_2; pfam13091 271848008048 putative active site [active] 271848008049 catalytic site [active] 271848008050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848008051 Helix-turn-helix domains; Region: HTH; cl00088 271848008052 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 271848008053 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 271848008054 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 271848008055 FAD binding site [chemical binding]; other site 271848008056 substrate binding site [chemical binding]; other site 271848008057 catalytic residues [active] 271848008058 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 271848008059 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 271848008060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008061 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848008062 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 271848008063 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848008064 substrate binding site [chemical binding]; other site 271848008065 oxyanion hole (OAH) forming residues; other site 271848008066 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 271848008067 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848008068 dimer interface [polypeptide binding]; other site 271848008069 active site 271848008070 enoyl-CoA hydratase; Provisional; Region: PRK06688 271848008071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848008072 substrate binding site [chemical binding]; other site 271848008073 oxyanion hole (OAH) forming residues; other site 271848008074 trimer interface [polypeptide binding]; other site 271848008075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 271848008076 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 271848008077 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 271848008078 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 271848008079 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 271848008080 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271848008081 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 271848008082 Walker A/P-loop; other site 271848008083 ATP binding site [chemical binding]; other site 271848008084 Q-loop/lid; other site 271848008085 ABC transporter signature motif; other site 271848008086 Walker B; other site 271848008087 D-loop; other site 271848008088 H-loop/switch region; other site 271848008089 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 271848008090 Substrate binding site; other site 271848008091 metal-binding site 271848008092 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848008093 Phosphotransferase enzyme family; Region: APH; pfam01636 271848008094 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 271848008095 Organic solvent tolerance protein; Region: OstA_C; pfam04453 271848008096 SurA N-terminal domain; Region: SurA_N_3; cl07813 271848008097 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 271848008098 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271848008099 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271848008100 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 271848008101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848008102 EamA-like transporter family; Region: EamA; cl01037 271848008103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848008104 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 271848008105 dimer interface [polypeptide binding]; other site 271848008106 active site 271848008107 metal binding site [ion binding]; metal-binding site 271848008108 glutathione binding site [chemical binding]; other site 271848008109 Protein of unknown function DUF45; Region: DUF45; cl00636 271848008110 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271848008111 putative acyl-acceptor binding pocket; other site 271848008112 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 271848008113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848008114 active site 271848008115 motif I; other site 271848008116 motif II; other site 271848008117 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 271848008118 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 271848008119 dimer interface [polypeptide binding]; other site 271848008120 motif 1; other site 271848008121 active site 271848008122 motif 2; other site 271848008123 motif 3; other site 271848008124 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 271848008125 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 271848008126 putative active site [active] 271848008127 catalytic triad [active] 271848008128 putative dimer interface [polypeptide binding]; other site 271848008129 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 271848008130 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 271848008131 Transporter associated domain; Region: CorC_HlyC; cl08393 271848008132 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 271848008133 putative active site pocket [active] 271848008134 dimerization interface [polypeptide binding]; other site 271848008135 putative catalytic residue [active] 271848008136 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 271848008137 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 271848008138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848008139 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 271848008140 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 271848008141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848008142 FeS/SAM binding site; other site 271848008143 TRAM domain; Region: TRAM; cl01282 271848008144 transcriptional regulator; Provisional; Region: PRK10632 271848008145 Helix-turn-helix domains; Region: HTH; cl00088 271848008146 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848008147 putative effector binding pocket; other site 271848008148 dimerization interface [polypeptide binding]; other site 271848008149 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848008150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008151 putative substrate translocation pore; other site 271848008152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848008153 non-specific DNA binding site [nucleotide binding]; other site 271848008154 salt bridge; other site 271848008155 sequence-specific DNA binding site [nucleotide binding]; other site 271848008156 Cupin domain; Region: Cupin_2; cl09118 271848008157 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 271848008158 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 271848008159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848008160 motif II; other site 271848008161 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 271848008162 amphipathic channel; other site 271848008163 Asn-Pro-Ala signature motifs; other site 271848008164 glycerol kinase; Provisional; Region: glpK; PRK00047 271848008165 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 271848008166 N- and C-terminal domain interface [polypeptide binding]; other site 271848008167 active site 271848008168 MgATP binding site [chemical binding]; other site 271848008169 catalytic site [active] 271848008170 metal binding site [ion binding]; metal-binding site 271848008171 glycerol binding site [chemical binding]; other site 271848008172 homotetramer interface [polypeptide binding]; other site 271848008173 homodimer interface [polypeptide binding]; other site 271848008174 FBP binding site [chemical binding]; other site 271848008175 protein IIAGlc interface [polypeptide binding]; other site 271848008176 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 271848008177 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 271848008178 Helix-turn-helix domains; Region: HTH; cl00088 271848008179 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 271848008180 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 271848008181 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 271848008182 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 271848008183 dinuclear metal binding motif [ion binding]; other site 271848008184 helicase 45; Provisional; Region: PTZ00424 271848008185 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271848008186 ATP binding site [chemical binding]; other site 271848008187 Mg++ binding site [ion binding]; other site 271848008188 motif III; other site 271848008189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848008190 nucleotide binding region [chemical binding]; other site 271848008191 ATP-binding site [chemical binding]; other site 271848008192 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848008193 Cytochrome c; Region: Cytochrom_C; cl11414 271848008194 Cytochrome c; Region: Cytochrom_C; cl11414 271848008195 Cytochrome c; Region: Cytochrom_C; cl11414 271848008196 Copper resistance protein D; Region: CopD; cl00563 271848008197 galactonate dehydratase; Provisional; Region: PRK14017 271848008198 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 271848008199 putative active site pocket [active] 271848008200 putative metal binding site [ion binding]; other site 271848008201 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 271848008202 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848008203 active site 271848008204 metal binding site [ion binding]; metal-binding site 271848008205 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 271848008206 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 271848008207 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 271848008208 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 271848008209 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 271848008210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271848008211 dimer interface [polypeptide binding]; other site 271848008212 phosphorylation site [posttranslational modification] 271848008213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848008214 ATP binding site [chemical binding]; other site 271848008215 Mg2+ binding site [ion binding]; other site 271848008216 G-X-G motif; other site 271848008217 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271848008218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008219 active site 271848008220 phosphorylation site [posttranslational modification] 271848008221 intermolecular recognition site; other site 271848008222 dimerization interface [polypeptide binding]; other site 271848008223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271848008224 Zn2+ binding site [ion binding]; other site 271848008225 Mg2+ binding site [ion binding]; other site 271848008226 Domain of unknown function (DUF305); Region: DUF305; cl15795 271848008227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848008228 PAS domain; Region: PAS_9; pfam13426 271848008229 putative active site [active] 271848008230 heme pocket [chemical binding]; other site 271848008231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848008232 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848008233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848008234 dimer interface [polypeptide binding]; other site 271848008235 putative CheW interface [polypeptide binding]; other site 271848008236 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 271848008237 FAD binding domain; Region: FAD_binding_4; pfam01565 271848008238 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 271848008239 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 271848008240 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848008241 active site residue [active] 271848008242 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271848008243 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 271848008244 Walker A/P-loop; other site 271848008245 ATP binding site [chemical binding]; other site 271848008246 Q-loop/lid; other site 271848008247 ABC transporter signature motif; other site 271848008248 Walker B; other site 271848008249 D-loop; other site 271848008250 H-loop/switch region; other site 271848008251 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 271848008252 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 271848008253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848008254 dimer interface [polypeptide binding]; other site 271848008255 conserved gate region; other site 271848008256 putative PBP binding loops; other site 271848008257 ABC-ATPase subunit interface; other site 271848008258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848008259 Erythromycin esterase; Region: Erythro_esteras; pfam05139 271848008260 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 271848008261 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 271848008262 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 271848008263 active site 271848008264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848008265 active site 271848008266 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 271848008267 Transglycosylase; Region: Transgly; cl07896 271848008268 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848008269 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848008270 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848008271 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 271848008272 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 271848008273 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 271848008274 active site 271848008275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848008276 Helix-turn-helix domains; Region: HTH; cl00088 271848008277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 271848008278 putative effector binding pocket; other site 271848008279 putative dimerization interface [polypeptide binding]; other site 271848008280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848008281 dimer interface [polypeptide binding]; other site 271848008282 phosphorylation site [posttranslational modification] 271848008283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848008284 ATP binding site [chemical binding]; other site 271848008285 Mg2+ binding site [ion binding]; other site 271848008286 G-X-G motif; other site 271848008287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008288 Response regulator receiver domain; Region: Response_reg; pfam00072 271848008289 active site 271848008290 phosphorylation site [posttranslational modification] 271848008291 intermolecular recognition site; other site 271848008292 dimerization interface [polypeptide binding]; other site 271848008293 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 271848008294 BetR domain; Region: BetR; pfam08667 271848008295 Response regulator receiver domain; Region: Response_reg; pfam00072 271848008296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008297 active site 271848008298 phosphorylation site [posttranslational modification] 271848008299 intermolecular recognition site; other site 271848008300 dimerization interface [polypeptide binding]; other site 271848008301 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848008302 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848008303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008304 putative substrate translocation pore; other site 271848008305 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848008306 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271848008307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848008308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848008309 dimer interface [polypeptide binding]; other site 271848008310 phosphorylation site [posttranslational modification] 271848008311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848008312 ATP binding site [chemical binding]; other site 271848008313 Mg2+ binding site [ion binding]; other site 271848008314 G-X-G motif; other site 271848008315 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 271848008316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008317 active site 271848008318 phosphorylation site [posttranslational modification] 271848008319 intermolecular recognition site; other site 271848008320 dimerization interface [polypeptide binding]; other site 271848008321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848008322 DNA binding site [nucleotide binding] 271848008323 recombinase A; Provisional; Region: recA; PRK09354 271848008324 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 271848008325 hexamer interface [polypeptide binding]; other site 271848008326 Walker A motif; other site 271848008327 ATP binding site [chemical binding]; other site 271848008328 Walker B motif; other site 271848008329 RecX family; Region: RecX; cl00936 271848008330 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 271848008331 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 271848008332 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848008333 CoA-ligase; Region: Ligase_CoA; cl02894 271848008334 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 271848008335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008336 CoA-ligase; Region: Ligase_CoA; cl02894 271848008337 Integral membrane protein TerC family; Region: TerC; cl10468 271848008338 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 271848008339 O-Antigen ligase; Region: Wzy_C; cl04850 271848008340 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 271848008341 Protein of unknown function (DUF2501); Region: DUF2501; cl08197 271848008342 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271848008343 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 271848008344 trimer interface [polypeptide binding]; other site 271848008345 dimer interface [polypeptide binding]; other site 271848008346 putative active site [active] 271848008347 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 271848008348 Peptidase family M48; Region: Peptidase_M48; cl12018 271848008349 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 271848008350 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 271848008351 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848008352 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848008353 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848008354 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848008355 putative active site [active] 271848008356 Zinc-finger domain; Region: zf-CHCC; cl01821 271848008357 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 271848008358 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 271848008359 homodimer interface [polypeptide binding]; other site 271848008360 substrate-cofactor binding pocket; other site 271848008361 catalytic residue [active] 271848008362 AzlC protein; Region: AzlC; cl00570 271848008363 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 271848008364 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 271848008365 Phosphoglycerate kinase; Region: PGK; pfam00162 271848008366 substrate binding site [chemical binding]; other site 271848008367 hinge regions; other site 271848008368 ADP binding site [chemical binding]; other site 271848008369 catalytic site [active] 271848008370 pyruvate kinase; Provisional; Region: PRK05826 271848008371 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848008372 domain interfaces; other site 271848008373 active site 271848008374 hypothetical protein; Provisional; Region: PRK08185 271848008375 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 271848008376 intersubunit interface [polypeptide binding]; other site 271848008377 active site 271848008378 zinc binding site [ion binding]; other site 271848008379 Na+ binding site [ion binding]; other site 271848008380 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 271848008381 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 271848008382 ATP binding site [chemical binding]; other site 271848008383 active site 271848008384 substrate binding site [chemical binding]; other site 271848008385 AIR carboxylase; Region: AIRC; cl00310 271848008386 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 271848008387 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848008388 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 271848008389 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 271848008390 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 271848008391 active site 271848008392 catalytic triad [active] 271848008393 oxyanion hole [active] 271848008394 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 271848008395 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 271848008396 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848008397 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 271848008398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008399 active site 271848008400 phosphorylation site [posttranslational modification] 271848008401 intermolecular recognition site; other site 271848008402 dimerization interface [polypeptide binding]; other site 271848008403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848008404 DNA binding site [nucleotide binding] 271848008405 sensor protein QseC; Provisional; Region: PRK10337 271848008406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848008407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848008408 ATP binding site [chemical binding]; other site 271848008409 Mg2+ binding site [ion binding]; other site 271848008410 G-X-G motif; other site 271848008411 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271848008412 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271848008413 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848008414 protein binding site [polypeptide binding]; other site 271848008415 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848008416 protein binding site [polypeptide binding]; other site 271848008417 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 271848008418 Domain of unknown function (DUF427); Region: DUF427; cl00998 271848008419 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 271848008420 hydrophobic ligand binding site; other site 271848008421 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 271848008422 Helix-turn-helix domains; Region: HTH; cl00088 271848008423 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 271848008424 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 271848008425 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848008426 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848008427 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 271848008428 Protein export membrane protein; Region: SecD_SecF; cl14618 271848008429 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 271848008430 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 271848008431 xanthine permease; Region: pbuX; TIGR03173 271848008432 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 271848008433 N- and C-terminal domain interface [polypeptide binding]; other site 271848008434 active site 271848008435 MgATP binding site [chemical binding]; other site 271848008436 catalytic site [active] 271848008437 metal binding site [ion binding]; metal-binding site 271848008438 carbohydrate binding site [chemical binding]; other site 271848008439 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848008440 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848008441 conserved cys residue [active] 271848008442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848008443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848008444 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 271848008445 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 271848008446 substrate binding site [chemical binding]; other site 271848008447 catalytic Zn binding site [ion binding]; other site 271848008448 NAD binding site [chemical binding]; other site 271848008449 structural Zn binding site [ion binding]; other site 271848008450 dimer interface [polypeptide binding]; other site 271848008451 Predicted esterase [General function prediction only]; Region: COG0627 271848008452 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848008453 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 271848008454 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 271848008455 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848008456 Walker A/P-loop; other site 271848008457 ATP binding site [chemical binding]; other site 271848008458 Q-loop/lid; other site 271848008459 ABC transporter signature motif; other site 271848008460 Walker B; other site 271848008461 D-loop; other site 271848008462 H-loop/switch region; other site 271848008463 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 271848008464 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 271848008465 metal binding site [ion binding]; metal-binding site 271848008466 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 271848008467 metal binding site 2 [ion binding]; metal-binding site 271848008468 putative DNA binding helix; other site 271848008469 metal binding site 1 [ion binding]; metal-binding site 271848008470 dimer interface [polypeptide binding]; other site 271848008471 structural Zn2+ binding site [ion binding]; other site 271848008472 sorbitol dehydrogenase; Provisional; Region: PRK07067 271848008473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008474 NAD(P) binding site [chemical binding]; other site 271848008475 active site 271848008476 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 271848008477 substrate binding site [chemical binding]; other site 271848008478 ATP binding site [chemical binding]; other site 271848008479 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 271848008480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848008481 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 271848008482 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 271848008483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848008484 dimer interface [polypeptide binding]; other site 271848008485 conserved gate region; other site 271848008486 putative PBP binding loops; other site 271848008487 ABC-ATPase subunit interface; other site 271848008488 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 271848008489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848008490 dimer interface [polypeptide binding]; other site 271848008491 conserved gate region; other site 271848008492 putative PBP binding loops; other site 271848008493 ABC-ATPase subunit interface; other site 271848008494 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 271848008495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848008496 active site 271848008497 motif I; other site 271848008498 motif II; other site 271848008499 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 271848008500 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 271848008501 Walker A/P-loop; other site 271848008502 ATP binding site [chemical binding]; other site 271848008503 Q-loop/lid; other site 271848008504 ABC transporter signature motif; other site 271848008505 Walker B; other site 271848008506 D-loop; other site 271848008507 H-loop/switch region; other site 271848008508 TOBE domain; Region: TOBE_2; cl01440 271848008509 TOBE domain; Region: TOBE_2; cl01440 271848008510 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848008511 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 271848008512 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 271848008513 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 271848008514 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 271848008515 N- and C-terminal domain interface [polypeptide binding]; other site 271848008516 active site 271848008517 catalytic site [active] 271848008518 metal binding site [ion binding]; metal-binding site 271848008519 xylulose binding site [chemical binding]; other site 271848008520 putative ATP binding site [chemical binding]; other site 271848008521 homodimer interface [polypeptide binding]; other site 271848008522 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 271848008523 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 271848008524 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 271848008525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848008526 Helix-turn-helix domains; Region: HTH; cl00088 271848008527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848008528 dimerization interface [polypeptide binding]; other site 271848008529 benzoylformate decarboxylase; Reviewed; Region: PRK07092 271848008530 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848008531 PYR/PP interface [polypeptide binding]; other site 271848008532 dimer interface [polypeptide binding]; other site 271848008533 TPP binding site [chemical binding]; other site 271848008534 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271848008535 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 271848008536 TPP-binding site [chemical binding]; other site 271848008537 dimer interface [polypeptide binding]; other site 271848008538 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 271848008539 NAD(P) binding site [chemical binding]; other site 271848008540 catalytic residues [active] 271848008541 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 271848008542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008543 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 271848008544 benzoate transport; Region: 2A0115; TIGR00895 271848008545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008546 putative substrate translocation pore; other site 271848008547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008548 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 271848008549 kynureninase; Region: kynureninase; TIGR01814 271848008550 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848008551 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848008552 catalytic residue [active] 271848008553 Putative cyclase; Region: Cyclase; cl00814 271848008554 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848008555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848008556 putative DNA binding site [nucleotide binding]; other site 271848008557 putative Zn2+ binding site [ion binding]; other site 271848008558 AsnC family; Region: AsnC_trans_reg; pfam01037 271848008559 Flavin Reductases; Region: FlaRed; cl00801 271848008560 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 271848008561 Protein of unknown function DUF72; Region: DUF72; cl00777 271848008562 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 271848008563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848008564 S-adenosylmethionine binding site [chemical binding]; other site 271848008565 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 271848008566 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271848008567 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 271848008568 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 271848008569 putative ATP binding site [chemical binding]; other site 271848008570 putative substrate interface [chemical binding]; other site 271848008571 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 271848008572 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 271848008573 Pirin-related protein [General function prediction only]; Region: COG1741 271848008574 Cupin domain; Region: Cupin_2; cl09118 271848008575 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 271848008576 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 271848008577 EamA-like transporter family; Region: EamA; cl01037 271848008578 AMIN domain; Region: AMIN; pfam11741 271848008579 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 271848008580 active site 271848008581 metal binding site [ion binding]; metal-binding site 271848008582 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 271848008583 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 271848008584 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 271848008585 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 271848008586 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 271848008587 DNA binding site [nucleotide binding] 271848008588 active site 271848008589 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 271848008590 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 271848008591 active site 271848008592 Int/Topo IB signature motif; other site 271848008593 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 271848008594 AMP-binding enzyme; Region: AMP-binding; cl15778 271848008595 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 271848008596 putative deacylase active site [active] 271848008597 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 271848008598 Protein of unknown function (DUF520); Region: DUF520; cl00723 271848008599 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 271848008600 FAD binding domain; Region: FAD_binding_4; pfam01565 271848008601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 271848008602 ornithine carbamoyltransferase; Provisional; Region: PRK00779 271848008603 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271848008604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008605 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 271848008606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848008607 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848008608 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 271848008609 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 271848008610 Uncharacterized conserved protein [Function unknown]; Region: COG2912 271848008611 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 271848008612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008613 NAD(P) binding site [chemical binding]; other site 271848008614 active site 271848008615 adenylate kinase; Reviewed; Region: adk; PRK00279 271848008616 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 271848008617 AMP-binding site [chemical binding]; other site 271848008618 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 271848008619 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 271848008620 Ligand binding site; other site 271848008621 oligomer interface; other site 271848008622 Trm112p-like protein; Region: Trm112p; cl01066 271848008623 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 271848008624 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 271848008625 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 271848008626 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 271848008627 generic binding surface II; other site 271848008628 generic binding surface I; other site 271848008629 superoxide dismutase; Provisional; Region: PRK10543 271848008630 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 271848008631 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 271848008632 Chromate transporter; Region: Chromate_transp; pfam02417 271848008633 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 271848008634 Chromate transporter; Region: Chromate_transp; pfam02417 271848008635 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848008636 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848008637 ligand binding site [chemical binding]; other site 271848008638 flexible hinge region; other site 271848008639 Helix-turn-helix domains; Region: HTH; cl00088 271848008640 Protein of unknown function (DUF962); Region: DUF962; cl01879 271848008641 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 271848008642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008643 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 271848008644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848008645 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848008646 putative transporter; Provisional; Region: PRK10504 271848008647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008648 putative substrate translocation pore; other site 271848008649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008650 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 271848008651 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 271848008652 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 271848008653 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 271848008654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848008655 DNA-binding site [nucleotide binding]; DNA binding site 271848008656 UTRA domain; Region: UTRA; cl01230 271848008657 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848008658 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 271848008659 active site 271848008660 catalytic tetrad [active] 271848008661 elongation factor G; Reviewed; Region: PRK00007 271848008662 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 271848008663 G1 box; other site 271848008664 putative GEF interaction site [polypeptide binding]; other site 271848008665 GTP/Mg2+ binding site [chemical binding]; other site 271848008666 Switch I region; other site 271848008667 G2 box; other site 271848008668 G3 box; other site 271848008669 Switch II region; other site 271848008670 G4 box; other site 271848008671 G5 box; other site 271848008672 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 271848008673 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 271848008674 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 271848008675 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 271848008676 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 271848008677 pseudouridine synthase; Region: TIGR00093 271848008678 active site 271848008679 isocitrate dehydrogenase; Validated; Region: PRK07362 271848008680 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 271848008681 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 271848008682 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848008683 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848008684 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 271848008685 DNA-binding site [nucleotide binding]; DNA binding site 271848008686 RNA-binding motif; other site 271848008687 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 271848008688 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 271848008689 Clp amino terminal domain; Region: Clp_N; pfam02861 271848008690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848008691 Walker A motif; other site 271848008692 ATP binding site [chemical binding]; other site 271848008693 Walker B motif; other site 271848008694 arginine finger; other site 271848008695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848008696 Walker A motif; other site 271848008697 ATP binding site [chemical binding]; other site 271848008698 Walker B motif; other site 271848008699 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848008700 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 271848008701 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 271848008702 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 271848008703 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 271848008704 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 271848008705 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 271848008706 trimer interface [polypeptide binding]; other site 271848008707 active site 271848008708 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 271848008709 Flavoprotein; Region: Flavoprotein; cl08021 271848008710 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 271848008711 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 271848008712 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 271848008713 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848008714 active site 271848008715 HIGH motif; other site 271848008716 nucleotide binding site [chemical binding]; other site 271848008717 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271848008718 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 271848008719 active site 271848008720 KMSKS motif; other site 271848008721 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 271848008722 tRNA binding surface [nucleotide binding]; other site 271848008723 anticodon binding site; other site 271848008724 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 271848008725 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 271848008726 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 271848008727 active site 271848008728 Riboflavin kinase; Region: Flavokinase; cl03312 271848008729 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 271848008730 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 271848008731 active site 271848008732 substrate binding site [chemical binding]; other site 271848008733 cosubstrate binding site; other site 271848008734 catalytic site [active] 271848008735 16S rRNA methyltransferase B; Provisional; Region: PRK14901 271848008736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848008737 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 271848008738 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271848008739 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848008740 Di-iron ligands [ion binding]; other site 271848008741 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848008742 Quinolinate synthetase A protein; Region: NadA; cl00420 271848008743 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 271848008744 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 271848008745 dimerization interface [polypeptide binding]; other site 271848008746 active site 271848008747 L-aspartate oxidase; Provisional; Region: PRK09077 271848008748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008749 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 271848008750 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 271848008751 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 271848008752 hypothetical protein; Reviewed; Region: PRK00024 271848008753 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 271848008754 MPN+ (JAMM) motif; other site 271848008755 Zinc-binding site [ion binding]; other site 271848008756 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 271848008757 LytB protein; Region: LYTB; cl00507 271848008758 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 271848008759 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848008760 TM-ABC transporter signature motif; other site 271848008761 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848008762 TM-ABC transporter signature motif; other site 271848008763 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848008764 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 271848008765 Walker A/P-loop; other site 271848008766 ATP binding site [chemical binding]; other site 271848008767 Q-loop/lid; other site 271848008768 ABC transporter signature motif; other site 271848008769 Walker B; other site 271848008770 D-loop; other site 271848008771 H-loop/switch region; other site 271848008772 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848008773 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271848008774 Walker A/P-loop; other site 271848008775 ATP binding site [chemical binding]; other site 271848008776 Q-loop/lid; other site 271848008777 ABC transporter signature motif; other site 271848008778 Walker B; other site 271848008779 D-loop; other site 271848008780 H-loop/switch region; other site 271848008781 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 271848008782 Uncharacterized conserved protein [Function unknown]; Region: COG5634 271848008783 putative acetyltransferase; Provisional; Region: PRK03624 271848008784 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848008785 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 271848008786 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848008787 inhibitor-cofactor binding pocket; inhibition site 271848008788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848008789 catalytic residue [active] 271848008790 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 271848008791 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848008792 catalytic loop [active] 271848008793 iron binding site [ion binding]; other site 271848008794 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 271848008795 FAD binding pocket [chemical binding]; other site 271848008796 FAD binding motif [chemical binding]; other site 271848008797 phosphate binding motif [ion binding]; other site 271848008798 beta-alpha-beta structure motif; other site 271848008799 NAD binding pocket [chemical binding]; other site 271848008800 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848008801 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 271848008802 putative NAD(P) binding site [chemical binding]; other site 271848008803 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 271848008804 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 271848008805 active site 271848008806 uracil binding [chemical binding]; other site 271848008807 Bacterial Ig-like domain; Region: Big_5; cl01012 271848008808 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848008809 Helix-turn-helix domains; Region: HTH; cl00088 271848008810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848008811 dimerization interface [polypeptide binding]; other site 271848008812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848008813 Helix-turn-helix domains; Region: HTH; cl00088 271848008814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848008815 dimerization interface [polypeptide binding]; other site 271848008816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848008817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 271848008818 MOSC domain; Region: MOSC; pfam03473 271848008819 3-alpha domain; Region: 3-alpha; pfam03475 271848008820 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848008821 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 271848008822 inhibitor site; inhibition site 271848008823 active site 271848008824 dimer interface [polypeptide binding]; other site 271848008825 catalytic residue [active] 271848008826 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 271848008827 intersubunit interface [polypeptide binding]; other site 271848008828 active site 271848008829 Zn2+ binding site [ion binding]; other site 271848008830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848008831 non-specific DNA binding site [nucleotide binding]; other site 271848008832 salt bridge; other site 271848008833 sequence-specific DNA binding site [nucleotide binding]; other site 271848008834 Cupin domain; Region: Cupin_2; cl09118 271848008835 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848008836 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 271848008837 dimerization interface [polypeptide binding]; other site 271848008838 substrate binding pocket [chemical binding]; other site 271848008839 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 271848008840 DctM-like transporters; Region: DctM; pfam06808 271848008841 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 271848008842 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 271848008843 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848008844 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848008845 DNA binding site [nucleotide binding] 271848008846 domain linker motif; other site 271848008847 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 271848008848 dimerization interface [polypeptide binding]; other site 271848008849 ligand binding site [chemical binding]; other site 271848008850 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 271848008851 Helix-turn-helix domains; Region: HTH; cl00088 271848008852 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 271848008853 substrate binding site [chemical binding]; other site 271848008854 dimerization interface [polypeptide binding]; other site 271848008855 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 271848008856 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848008857 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848008858 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 271848008859 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848008860 Active Sites [active] 271848008861 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 271848008862 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848008863 Active Sites [active] 271848008864 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 271848008865 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 271848008866 CysD dimerization site [polypeptide binding]; other site 271848008867 G1 box; other site 271848008868 putative GEF interaction site [polypeptide binding]; other site 271848008869 GTP/Mg2+ binding site [chemical binding]; other site 271848008870 Switch I region; other site 271848008871 G2 box; other site 271848008872 G3 box; other site 271848008873 Switch II region; other site 271848008874 G4 box; other site 271848008875 G5 box; other site 271848008876 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 271848008877 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 271848008878 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271848008879 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 271848008880 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 271848008881 putative active site [active] 271848008882 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 271848008883 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 271848008884 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 271848008885 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 271848008886 multifunctional aminopeptidase A; Provisional; Region: PRK00913 271848008887 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 271848008888 interface (dimer of trimers) [polypeptide binding]; other site 271848008889 Substrate-binding/catalytic site; other site 271848008890 Zn-binding sites [ion binding]; other site 271848008891 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 271848008892 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 271848008893 Cytochrome c; Region: Cytochrom_C; cl11414 271848008894 Dehydratase family; Region: ILVD_EDD; cl00340 271848008895 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 271848008896 Helix-turn-helix domains; Region: HTH; cl00088 271848008897 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 271848008898 putative dimerization interface [polypeptide binding]; other site 271848008899 putative substrate binding pocket [chemical binding]; other site 271848008900 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 271848008901 Protein of unknown function (DUF541); Region: SIMPL; cl01077 271848008902 EVE domain; Region: EVE; cl00728 271848008903 Cell division protein ZapA; Region: ZapA; cl01146 271848008904 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 271848008905 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 271848008906 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848008907 N-terminal plug; other site 271848008908 ligand-binding site [chemical binding]; other site 271848008909 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 271848008910 dimer interface [polypeptide binding]; other site 271848008911 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 271848008912 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 271848008913 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271848008914 Walker A/P-loop; other site 271848008915 ATP binding site [chemical binding]; other site 271848008916 Q-loop/lid; other site 271848008917 ABC transporter signature motif; other site 271848008918 Walker B; other site 271848008919 D-loop; other site 271848008920 H-loop/switch region; other site 271848008921 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 271848008922 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 271848008923 putative dimer interface [polypeptide binding]; other site 271848008924 active site pocket [active] 271848008925 putative cataytic base [active] 271848008926 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 271848008927 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 271848008928 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 271848008929 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 271848008930 cobalamin binding residues [chemical binding]; other site 271848008931 putative BtuC binding residues; other site 271848008932 dimer interface [polypeptide binding]; other site 271848008933 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 271848008934 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848008935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848008936 catalytic residue [active] 271848008937 CobD/Cbib protein; Region: CobD_Cbib; cl00561 271848008938 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 271848008939 homotrimer interface [polypeptide binding]; other site 271848008940 Walker A motif; other site 271848008941 GTP binding site [chemical binding]; other site 271848008942 Walker B motif; other site 271848008943 cobyric acid synthase; Provisional; Region: PRK00784 271848008944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848008945 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 271848008946 catalytic triad [active] 271848008947 DoxX; Region: DoxX; cl00976 271848008948 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271848008949 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848008950 P-loop; other site 271848008951 Magnesium ion binding site [ion binding]; other site 271848008952 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 271848008953 tetramerization interface [polypeptide binding]; other site 271848008954 active site 271848008955 pantoate--beta-alanine ligase; Region: panC; TIGR00018 271848008956 Pantoate-beta-alanine ligase; Region: PanC; cd00560 271848008957 active site 271848008958 ATP-binding site [chemical binding]; other site 271848008959 pantoate-binding site; other site 271848008960 HXXH motif; other site 271848008961 ScpA/B protein; Region: ScpA_ScpB; cl00598 271848008962 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 271848008963 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 271848008964 Surface antigen; Region: Bac_surface_Ag; cl03097 271848008965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 271848008966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 271848008967 Family of unknown function (DUF490); Region: DUF490; pfam04357 271848008968 O-methyltransferase; Region: Methyltransf_2; pfam00891 271848008969 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 271848008970 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 271848008971 active site 271848008972 HIGH motif; other site 271848008973 KMSKS motif; other site 271848008974 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 271848008975 tRNA binding surface [nucleotide binding]; other site 271848008976 anticodon binding site; other site 271848008977 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 271848008978 dimer interface [polypeptide binding]; other site 271848008979 putative tRNA-binding site [nucleotide binding]; other site 271848008980 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848008981 ligand binding site [chemical binding]; other site 271848008982 Domain of unknown function DUF59; Region: DUF59; cl00941 271848008983 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 271848008984 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 271848008985 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 271848008986 E-class dimer interface [polypeptide binding]; other site 271848008987 P-class dimer interface [polypeptide binding]; other site 271848008988 active site 271848008989 Cu2+ binding site [ion binding]; other site 271848008990 Zn2+ binding site [ion binding]; other site 271848008991 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 271848008992 trimer interface [polypeptide binding]; other site 271848008993 active site 271848008994 arginine decarboxylase; Provisional; Region: PRK15029 271848008995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 271848008996 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848008997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848008998 catalytic residue [active] 271848008999 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 271848009000 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 271848009001 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 271848009002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848009003 motif II; other site 271848009004 argininosuccinate lyase; Provisional; Region: PRK00855 271848009005 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 271848009006 active sites [active] 271848009007 tetramer interface [polypeptide binding]; other site 271848009008 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 271848009009 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 271848009010 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 271848009011 PapC C-terminal domain; Region: PapC_C; pfam13953 271848009012 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 271848009013 Spore Coat Protein U domain; Region: SCPU; cl02253 271848009014 Spore Coat Protein U domain; Region: SCPU; cl02253 271848009015 Spore Coat Protein U domain; Region: SCPU; cl02253 271848009016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848009017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848009018 S-adenosylmethionine binding site [chemical binding]; other site 271848009019 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 271848009020 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 271848009021 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 271848009022 domain interfaces; other site 271848009023 active site 271848009024 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 271848009025 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 271848009026 active site 271848009027 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 271848009028 hemY protein; Region: hemY_coli; TIGR00540 271848009029 HemY protein N-terminus; Region: HemY_N; pfam07219 271848009030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271848009031 TPR motif; other site 271848009032 binding surface 271848009033 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 271848009034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009035 putative substrate translocation pore; other site 271848009036 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 271848009037 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848009038 putative NAD(P) binding site [chemical binding]; other site 271848009039 active site 271848009040 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848009041 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 271848009042 NAD(P) binding site [chemical binding]; other site 271848009043 catalytic residues [active] 271848009044 catalytic residues [active] 271848009045 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 271848009046 dimer interface [polypeptide binding]; other site 271848009047 substrate binding site [chemical binding]; other site 271848009048 metal binding sites [ion binding]; metal-binding site 271848009049 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 271848009050 GIY-YIG motif/motif A; other site 271848009051 putative active site [active] 271848009052 putative metal binding site [ion binding]; other site 271848009053 putative transporter; Provisional; Region: PRK10504 271848009054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009055 putative substrate translocation pore; other site 271848009056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009057 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848009058 Protein of unknown function, DUF482; Region: DUF482; pfam04339 271848009059 NAD synthetase; Provisional; Region: PRK13981 271848009060 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 271848009061 multimer interface [polypeptide binding]; other site 271848009062 active site 271848009063 catalytic triad [active] 271848009064 protein interface 1 [polypeptide binding]; other site 271848009065 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 271848009066 homodimer interface [polypeptide binding]; other site 271848009067 NAD binding pocket [chemical binding]; other site 271848009068 ATP binding pocket [chemical binding]; other site 271848009069 Mg binding site [ion binding]; other site 271848009070 active-site loop [active] 271848009071 Nitrogen regulatory protein P-II; Region: P-II; cl00412 271848009072 Nitrogen regulatory protein P-II; Region: P-II; smart00938 271848009073 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848009074 trimer interface [polypeptide binding]; other site 271848009075 eyelet of channel; other site 271848009076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848009077 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 271848009078 putative substrate binding pocket [chemical binding]; other site 271848009079 dimerization interface [polypeptide binding]; other site 271848009080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848009081 Coenzyme A binding pocket [chemical binding]; other site 271848009082 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 271848009083 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 271848009084 Walker A/P-loop; other site 271848009085 ATP binding site [chemical binding]; other site 271848009086 Q-loop/lid; other site 271848009087 ABC transporter signature motif; other site 271848009088 Walker B; other site 271848009089 D-loop; other site 271848009090 H-loop/switch region; other site 271848009091 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848009092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848009093 dimer interface [polypeptide binding]; other site 271848009094 conserved gate region; other site 271848009095 putative PBP binding loops; other site 271848009096 ABC-ATPase subunit interface; other site 271848009097 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848009098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848009099 dimer interface [polypeptide binding]; other site 271848009100 conserved gate region; other site 271848009101 putative PBP binding loops; other site 271848009102 ABC-ATPase subunit interface; other site 271848009103 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 271848009104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848009105 substrate binding pocket [chemical binding]; other site 271848009106 membrane-bound complex binding site; other site 271848009107 hinge residues; other site 271848009108 Pirin-related protein [General function prediction only]; Region: COG1741 271848009109 Cupin domain; Region: Cupin_2; cl09118 271848009110 osmolarity response regulator; Provisional; Region: ompR; PRK09468 271848009111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848009112 active site 271848009113 phosphorylation site [posttranslational modification] 271848009114 intermolecular recognition site; other site 271848009115 dimerization interface [polypeptide binding]; other site 271848009116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848009117 DNA binding site [nucleotide binding] 271848009118 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 271848009119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848009120 dimer interface [polypeptide binding]; other site 271848009121 phosphorylation site [posttranslational modification] 271848009122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848009123 ATP binding site [chemical binding]; other site 271848009124 Mg2+ binding site [ion binding]; other site 271848009125 G-X-G motif; other site 271848009126 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 271848009127 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 271848009128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848009129 dimer interface [polypeptide binding]; other site 271848009130 conserved gate region; other site 271848009131 putative PBP binding loops; other site 271848009132 ABC-ATPase subunit interface; other site 271848009133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848009134 dimer interface [polypeptide binding]; other site 271848009135 conserved gate region; other site 271848009136 putative PBP binding loops; other site 271848009137 ABC-ATPase subunit interface; other site 271848009138 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271848009139 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 271848009140 Walker A/P-loop; other site 271848009141 ATP binding site [chemical binding]; other site 271848009142 Q-loop/lid; other site 271848009143 ABC transporter signature motif; other site 271848009144 Walker B; other site 271848009145 D-loop; other site 271848009146 H-loop/switch region; other site 271848009147 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 271848009148 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 271848009149 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 271848009150 active site 271848009151 homotetramer interface [polypeptide binding]; other site 271848009152 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848009153 AAA domain; Region: AAA_28; pfam13521 271848009154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009155 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848009156 putative substrate translocation pore; other site 271848009157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009158 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 271848009159 substrate binding site [chemical binding]; other site 271848009160 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178 271848009161 secondary substrate binding site; other site 271848009162 primary substrate binding site; other site 271848009163 inhibition loop; other site 271848009164 dimerization interface [polypeptide binding]; other site 271848009165 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 271848009166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848009167 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848009168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848009169 Walker A motif; other site 271848009170 ATP binding site [chemical binding]; other site 271848009171 Walker B motif; other site 271848009172 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271848009173 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848009174 hypothetical protein; Region: PHA00662 271848009175 hypothetical protein; Region: PHA00661 271848009176 hypothetical protein; Region: PHA00661 271848009177 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848009178 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848009179 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 271848009180 catalytic residue [active] 271848009181 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848009182 MULE transposase domain; Region: MULE; pfam10551 271848009183 integrase; Provisional; Region: PRK09692 271848009184 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 271848009185 active site 271848009186 Int/Topo IB signature motif; other site 271848009187 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423 271848009188 putative active site [active] 271848009189 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 271848009190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848009191 Walker A motif; other site 271848009192 ATP binding site [chemical binding]; other site 271848009193 Walker B motif; other site 271848009194 arginine finger; other site 271848009195 Helix-turn-helix domains; Region: HTH; cl00088 271848009196 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 271848009197 Rubredoxin; Region: Rubredoxin; pfam00301 271848009198 iron binding site [ion binding]; other site 271848009199 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 271848009200 ABC transporter ATPase component; Reviewed; Region: PRK11147 271848009201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848009202 Walker A/P-loop; other site 271848009203 ATP binding site [chemical binding]; other site 271848009204 Q-loop/lid; other site 271848009205 ABC transporter signature motif; other site 271848009206 Walker B; other site 271848009207 D-loop; other site 271848009208 H-loop/switch region; other site 271848009209 ABC transporter; Region: ABC_tran_2; pfam12848 271848009210 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271848009211 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 271848009212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848009213 ATP binding site [chemical binding]; other site 271848009214 Mg2+ binding site [ion binding]; other site 271848009215 G-X-G motif; other site 271848009216 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 271848009217 anchoring element; other site 271848009218 dimer interface [polypeptide binding]; other site 271848009219 ATP binding site [chemical binding]; other site 271848009220 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 271848009221 active site 271848009222 metal binding site [ion binding]; metal-binding site 271848009223 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 271848009224 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 271848009225 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 271848009226 CAP-like domain; other site 271848009227 active site 271848009228 primary dimer interface [polypeptide binding]; other site 271848009229 Copper resistance protein D; Region: CopD; cl00563 271848009230 Helix-turn-helix domains; Region: HTH; cl00088 271848009231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848009232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848009233 dimerization interface [polypeptide binding]; other site 271848009234 Predicted membrane protein [Function unknown]; Region: COG4125 271848009235 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 271848009236 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 271848009237 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 271848009238 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 271848009239 Chromate transporter; Region: Chromate_transp; pfam02417 271848009240 Chromate transporter; Region: Chromate_transp; pfam02417 271848009241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848009242 metal binding site [ion binding]; metal-binding site 271848009243 active site 271848009244 I-site; other site 271848009245 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848009246 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 271848009247 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 271848009248 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 271848009249 homotrimer interaction site [polypeptide binding]; other site 271848009250 putative active site [active] 271848009251 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 271848009252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848009253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848009254 homodimer interface [polypeptide binding]; other site 271848009255 catalytic residue [active] 271848009256 EamA-like transporter family; Region: EamA; cl01037 271848009257 EamA-like transporter family; Region: EamA; cl01037 271848009258 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848009259 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848009260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848009261 DNA-binding site [nucleotide binding]; DNA binding site 271848009262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848009263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848009264 homodimer interface [polypeptide binding]; other site 271848009265 catalytic residue [active] 271848009266 heat shock protein 90; Provisional; Region: PRK05218 271848009267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848009268 ATP binding site [chemical binding]; other site 271848009269 Mg2+ binding site [ion binding]; other site 271848009270 G-X-G motif; other site 271848009271 UTRA domain; Region: UTRA; cl01230 271848009272 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 271848009273 putative active site [active] 271848009274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848009275 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 271848009276 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 271848009277 Na binding site [ion binding]; other site 271848009278 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 271848009279 dimer interface [polypeptide binding]; other site 271848009280 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848009281 transaldolase-like protein; Provisional; Region: PTZ00411 271848009282 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 271848009283 active site 271848009284 dimer interface [polypeptide binding]; other site 271848009285 catalytic residue [active] 271848009286 benzoate transporter; Region: benE; TIGR00843 271848009287 Benzoate membrane transport protein; Region: BenE; pfam03594 271848009288 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271848009289 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848009290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848009291 Walker A motif; other site 271848009292 ATP binding site [chemical binding]; other site 271848009293 Walker B motif; other site 271848009294 arginine finger; other site 271848009295 Cytochrome c; Region: Cytochrom_C; cl11414 271848009296 Cytochrome c; Region: Cytochrom_C; cl11414 271848009297 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 271848009298 EamA-like transporter family; Region: EamA; cl01037 271848009299 EamA-like transporter family; Region: EamA; cl01037 271848009300 endonuclease III; Provisional; Region: PRK10702 271848009301 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271848009302 minor groove reading motif; other site 271848009303 helix-hairpin-helix signature motif; other site 271848009304 substrate binding pocket [chemical binding]; other site 271848009305 active site 271848009306 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 271848009307 ferredoxin; Provisional; Region: PRK06991 271848009308 Putative Fe-S cluster; Region: FeS; pfam04060 271848009309 4Fe-4S binding domain; Region: Fer4; cl02805 271848009310 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 271848009311 Helix-turn-helix domains; Region: HTH; cl00088 271848009312 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 271848009313 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 271848009314 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 271848009315 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 271848009316 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 271848009317 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 271848009318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848009319 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 271848009320 META domain; Region: META; cl01245 271848009321 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 271848009322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848009323 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848009324 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 271848009325 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271848009326 DEAD-like helicases superfamily; Region: DEXDc; smart00487 271848009327 ATP binding site [chemical binding]; other site 271848009328 Mg++ binding site [ion binding]; other site 271848009329 motif III; other site 271848009330 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848009331 nucleotide binding region [chemical binding]; other site 271848009332 ATP-binding site [chemical binding]; other site 271848009333 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848009334 active site 271848009335 HIGH motif; other site 271848009336 nucleotide binding site [chemical binding]; other site 271848009337 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848009338 KMSKS motif; other site 271848009339 rhodanese superfamily protein; Provisional; Region: PRK05320 271848009340 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 271848009341 active site residue [active] 271848009342 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 271848009343 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 271848009344 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 271848009345 generic binding surface II; other site 271848009346 generic binding surface I; other site 271848009347 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 271848009348 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271848009349 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 271848009350 Walker A/P-loop; other site 271848009351 ATP binding site [chemical binding]; other site 271848009352 Q-loop/lid; other site 271848009353 ABC transporter signature motif; other site 271848009354 Walker B; other site 271848009355 D-loop; other site 271848009356 H-loop/switch region; other site 271848009357 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 271848009358 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271848009359 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848009360 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848009361 putative active site [active] 271848009362 O-Antigen ligase; Region: Wzy_C; cl04850 271848009363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848009364 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 271848009365 putative ADP-binding pocket [chemical binding]; other site 271848009366 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848009367 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848009368 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848009369 putative active site [active] 271848009370 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 271848009371 putative metal binding site; other site 271848009372 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 271848009373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848009374 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848009375 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 271848009376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848009377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848009378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848009379 dimerization interface [polypeptide binding]; other site 271848009380 Helix-turn-helix domains; Region: HTH; cl00088 271848009381 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848009382 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848009383 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 271848009384 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 271848009385 Pectinacetylesterase; Region: PAE; pfam03283 271848009386 xanthine permease; Region: pbuX; TIGR03173 271848009387 ribonuclease G; Provisional; Region: PRK11712 271848009388 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 271848009389 homodimer interface [polypeptide binding]; other site 271848009390 oligonucleotide binding site [chemical binding]; other site 271848009391 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 271848009392 putative active site [active] 271848009393 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 271848009394 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 271848009395 Oligomerisation domain; Region: Oligomerisation; cl00519 271848009396 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 271848009397 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 271848009398 active site 271848009399 (T/H)XGH motif; other site 271848009400 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 271848009401 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 271848009402 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 271848009403 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848009404 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 271848009405 Transcriptional regulator; Region: Transcrip_reg; cl00361 271848009406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848009407 active site 271848009408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848009409 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 271848009410 putative NAD(P) binding site [chemical binding]; other site 271848009411 putative active site [active] 271848009412 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 271848009413 active site 271848009414 dimer interfaces [polypeptide binding]; other site 271848009415 catalytic residues [active] 271848009416 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 271848009417 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 271848009418 NADP binding site [chemical binding]; other site 271848009419 dimer interface [polypeptide binding]; other site 271848009420 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 271848009421 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 271848009422 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848009423 K+-transporting ATPase, c chain; Region: KdpC; cl00944 271848009424 sensor protein KdpD; Provisional; Region: PRK10490 271848009425 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 271848009426 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 271848009427 Ligand Binding Site [chemical binding]; other site 271848009428 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 271848009429 GAF domain; Region: GAF; cl15785 271848009430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848009431 dimer interface [polypeptide binding]; other site 271848009432 phosphorylation site [posttranslational modification] 271848009433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848009434 ATP binding site [chemical binding]; other site 271848009435 Mg2+ binding site [ion binding]; other site 271848009436 G-X-G motif; other site 271848009437 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 271848009438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848009439 active site 271848009440 phosphorylation site [posttranslational modification] 271848009441 intermolecular recognition site; other site 271848009442 dimerization interface [polypeptide binding]; other site 271848009443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848009444 DNA binding site [nucleotide binding] 271848009445 Domain of unknown function (DUF333); Region: DUF333; pfam03891 271848009446 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 271848009447 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 271848009448 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 271848009449 FtsX-like permease family; Region: FtsX; cl15850 271848009450 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 271848009451 apolar tunnel; other site 271848009452 heme binding site [chemical binding]; other site 271848009453 dimerization interface [polypeptide binding]; other site 271848009454 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 271848009455 amidase; Provisional; Region: PRK07042 271848009456 Amidase; Region: Amidase; cl11426 271848009457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009458 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848009459 putative substrate translocation pore; other site 271848009460 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 271848009461 short chain dehydrogenase; Provisional; Region: PRK06123 271848009462 classical (c) SDRs; Region: SDR_c; cd05233 271848009463 NAD(P) binding site [chemical binding]; other site 271848009464 active site 271848009465 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271848009466 Helix-turn-helix domains; Region: HTH; cl00088 271848009467 Bacterial transcriptional repressor; Region: TetR; pfam13972 271848009468 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 271848009469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848009470 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 271848009471 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848009472 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 271848009473 putative active site [active] 271848009474 putative metal binding site [ion binding]; other site 271848009475 RDD family; Region: RDD; cl00746 271848009476 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 271848009477 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 271848009478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848009479 RNA polymerase factor sigma-70; Validated; Region: PRK09047 271848009480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848009481 DNA binding residues [nucleotide binding] 271848009482 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 271848009483 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848009484 PYR/PP interface [polypeptide binding]; other site 271848009485 dimer interface [polypeptide binding]; other site 271848009486 TPP binding site [chemical binding]; other site 271848009487 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271848009488 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 271848009489 TPP-binding site [chemical binding]; other site 271848009490 dimer interface [polypeptide binding]; other site 271848009491 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 271848009492 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 271848009493 putative valine binding site [chemical binding]; other site 271848009494 dimer interface [polypeptide binding]; other site 271848009495 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 271848009496 ketol-acid reductoisomerase; Provisional; Region: PRK05479 271848009497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848009498 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 271848009499 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 271848009500 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 271848009501 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 271848009502 2-isopropylmalate synthase; Validated; Region: PRK00915 271848009503 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 271848009504 active site 271848009505 catalytic residues [active] 271848009506 metal binding site [ion binding]; metal-binding site 271848009507 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 271848009508 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 271848009509 Sulfate transporter family; Region: Sulfate_transp; cl15842 271848009510 Sulfate transporter family; Region: Sulfate_transp; cl15842 271848009511 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 271848009512 active site clefts [active] 271848009513 zinc binding site [ion binding]; other site 271848009514 dimer interface [polypeptide binding]; other site 271848009515 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271848009516 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 271848009517 putative ligand binding site [chemical binding]; other site 271848009518 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 271848009519 16S/18S rRNA binding site [nucleotide binding]; other site 271848009520 S13e-L30e interaction site [polypeptide binding]; other site 271848009521 25S rRNA binding site [nucleotide binding]; other site 271848009522 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 271848009523 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 271848009524 RNase E interface [polypeptide binding]; other site 271848009525 trimer interface [polypeptide binding]; other site 271848009526 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 271848009527 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 271848009528 RNase E interface [polypeptide binding]; other site 271848009529 trimer interface [polypeptide binding]; other site 271848009530 active site 271848009531 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 271848009532 putative nucleic acid binding region [nucleotide binding]; other site 271848009533 G-X-X-G motif; other site 271848009534 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 271848009535 RNA binding site [nucleotide binding]; other site 271848009536 domain interface; other site 271848009537 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 271848009538 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 271848009539 NAD(P) binding site [chemical binding]; other site 271848009540 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 271848009541 substrate binding site [chemical binding]; other site 271848009542 dimer interface [polypeptide binding]; other site 271848009543 catalytic triad [active] 271848009544 Preprotein translocase SecG subunit; Region: SecG; cl09123 271848009545 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 271848009546 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 271848009547 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 271848009548 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 271848009549 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 271848009550 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 271848009551 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 271848009552 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 271848009553 putative dimer interface [polypeptide binding]; other site 271848009554 [2Fe-2S] cluster binding site [ion binding]; other site 271848009555 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 271848009556 SLBB domain; Region: SLBB; pfam10531 271848009557 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 271848009558 NADH dehydrogenase subunit G; Validated; Region: PRK09129 271848009559 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848009560 catalytic loop [active] 271848009561 iron binding site [ion binding]; other site 271848009562 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 271848009563 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 271848009564 NADH dehydrogenase; Region: NADHdh; cl00469 271848009565 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 271848009566 4Fe-4S binding domain; Region: Fer4; cl02805 271848009567 4Fe-4S binding domain; Region: Fer4; cl02805 271848009568 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 271848009569 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 271848009570 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 271848009571 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 271848009572 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 271848009573 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 271848009574 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 271848009575 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 271848009576 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 271848009577 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 271848009578 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 271848009579 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 271848009580 dimer interface [polypeptide binding]; other site 271848009581 ADP-ribose binding site [chemical binding]; other site 271848009582 active site 271848009583 nudix motif; other site 271848009584 metal binding site [ion binding]; metal-binding site 271848009585 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 271848009586 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 271848009587 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 271848009588 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 271848009589 FAD binding site [chemical binding]; other site 271848009590 substrate binding site [chemical binding]; other site 271848009591 catalytic base [active] 271848009592 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 271848009593 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271848009594 active site 271848009595 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 271848009596 putative active site [active] 271848009597 putative catalytic site [active] 271848009598 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 271848009599 putative active site [active] 271848009600 putative catalytic site [active] 271848009601 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848009602 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 271848009603 FAD binding site [chemical binding]; other site 271848009604 substrate binding site [chemical binding]; other site 271848009605 catalytic base [active] 271848009606 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 271848009607 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 271848009608 putative active site [active] 271848009609 putative substrate binding site [chemical binding]; other site 271848009610 ATP binding site [chemical binding]; other site 271848009611 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 271848009612 catalytic core [active] 271848009613 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 271848009614 enoyl-CoA hydratase; Provisional; Region: PRK07511 271848009615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848009616 substrate binding site [chemical binding]; other site 271848009617 oxyanion hole (OAH) forming residues; other site 271848009618 trimer interface [polypeptide binding]; other site 271848009619 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848009620 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 271848009621 C-terminal domain interface [polypeptide binding]; other site 271848009622 GSH binding site (G-site) [chemical binding]; other site 271848009623 dimer interface [polypeptide binding]; other site 271848009624 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 271848009625 putative N-terminal domain interface [polypeptide binding]; other site 271848009626 putative dimer interface [polypeptide binding]; other site 271848009627 putative substrate binding pocket (H-site) [chemical binding]; other site 271848009628 methionine aminotransferase; Validated; Region: PRK09082 271848009629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848009630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848009631 homodimer interface [polypeptide binding]; other site 271848009632 catalytic residue [active] 271848009633 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 271848009634 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 271848009635 Protein of unknown function (DUF328); Region: DUF328; cl01143 271848009636 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 271848009637 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 271848009638 putative active site [active] 271848009639 Zn binding site [ion binding]; other site 271848009640 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 271848009641 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848009642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848009643 active site 271848009644 phosphorylation site [posttranslational modification] 271848009645 intermolecular recognition site; other site 271848009646 dimerization interface [polypeptide binding]; other site 271848009647 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848009648 DNA binding residues [nucleotide binding] 271848009649 dimerization interface [polypeptide binding]; other site 271848009650 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 271848009651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848009652 Helix-turn-helix domains; Region: HTH; cl00088 271848009653 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848009654 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848009655 MULE transposase domain; Region: MULE; pfam10551 271848009656 Integrase core domain; Region: rve; cl01316 271848009657 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848009658 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 271848009659 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 271848009660 putative [4Fe-4S] binding site [ion binding]; other site 271848009661 putative molybdopterin cofactor binding site [chemical binding]; other site 271848009662 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 271848009663 putative molybdopterin cofactor binding site; other site 271848009664 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 271848009665 AMP-binding enzyme; Region: AMP-binding; cl15778 271848009666 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848009667 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848009668 trimer interface [polypeptide binding]; other site 271848009669 eyelet of channel; other site 271848009670 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 271848009671 diiron binding motif [ion binding]; other site 271848009672 cell division protein MraZ; Reviewed; Region: PRK00326 271848009673 MraZ protein; Region: MraZ; pfam02381 271848009674 MraZ protein; Region: MraZ; pfam02381 271848009675 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 271848009676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848009677 Septum formation initiator; Region: DivIC; cl11433 271848009678 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 271848009679 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 271848009680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848009681 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 271848009682 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848009683 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848009684 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271848009685 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 271848009686 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848009687 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848009688 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 271848009689 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 271848009690 Mg++ binding site [ion binding]; other site 271848009691 putative catalytic motif [active] 271848009692 putative substrate binding site [chemical binding]; other site 271848009693 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 271848009694 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848009695 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848009696 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 271848009697 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 271848009698 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 271848009699 active site 271848009700 homodimer interface [polypeptide binding]; other site 271848009701 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 271848009702 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271848009703 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848009704 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848009705 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 271848009706 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 271848009707 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848009708 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 271848009709 Cell division protein FtsQ; Region: FtsQ; pfam03799 271848009710 cell division protein FtsA; Region: ftsA; TIGR01174 271848009711 Cell division protein FtsA; Region: FtsA; cl11496 271848009712 Cell division protein FtsA; Region: FtsA; cl11496 271848009713 cell division protein FtsZ; Validated; Region: PRK09330 271848009714 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 271848009715 nucleotide binding site [chemical binding]; other site 271848009716 SulA interaction site; other site 271848009717 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 271848009718 catalytic triad [active] 271848009719 dimer interface [polypeptide binding]; other site 271848009720 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 271848009721 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 271848009722 Protein of unknown function (DUF721); Region: DUF721; cl02324 271848009723 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 271848009724 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 271848009725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848009726 nucleotide binding region [chemical binding]; other site 271848009727 ATP-binding site [chemical binding]; other site 271848009728 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 271848009729 SEC-C motif; Region: SEC-C; pfam02810 271848009730 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 271848009731 heterotetramer interface [polypeptide binding]; other site 271848009732 active site pocket [active] 271848009733 cleavage site 271848009734 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 271848009735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848009736 Walker A motif; other site 271848009737 ATP binding site [chemical binding]; other site 271848009738 Walker B motif; other site 271848009739 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 271848009740 active site 271848009741 8-oxo-dGMP binding site [chemical binding]; other site 271848009742 nudix motif; other site 271848009743 metal binding site [ion binding]; metal-binding site 271848009744 Domain of unknown function (DUF329); Region: DUF329; cl01144 271848009745 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 271848009746 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 271848009747 CoA-binding site [chemical binding]; other site 271848009748 ATP-binding [chemical binding]; other site 271848009749 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 271848009750 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 271848009751 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 271848009752 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848009753 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848009754 Type II/IV secretion system protein; Region: T2SE; pfam00437 271848009755 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 271848009756 Walker A motif; other site 271848009757 ATP binding site [chemical binding]; other site 271848009758 Walker B motif; other site 271848009759 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 271848009760 Domain of unknown function DUF21; Region: DUF21; pfam01595 271848009761 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 271848009762 Transporter associated domain; Region: CorC_HlyC; cl08393 271848009763 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 271848009764 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 271848009765 substrate binding pocket [chemical binding]; other site 271848009766 chain length determination region; other site 271848009767 substrate-Mg2+ binding site; other site 271848009768 catalytic residues [active] 271848009769 aspartate-rich region 1; other site 271848009770 active site lid residues [active] 271848009771 aspartate-rich region 2; other site 271848009772 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 271848009773 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 271848009774 GTPase CgtA; Reviewed; Region: obgE; PRK12298 271848009775 GTP1/OBG; Region: GTP1_OBG; pfam01018 271848009776 Obg GTPase; Region: Obg; cd01898 271848009777 G1 box; other site 271848009778 GTP/Mg2+ binding site [chemical binding]; other site 271848009779 Switch I region; other site 271848009780 G2 box; other site 271848009781 G3 box; other site 271848009782 Switch II region; other site 271848009783 G4 box; other site 271848009784 G5 box; other site 271848009785 gamma-glutamyl kinase; Provisional; Region: PRK05429 271848009786 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 271848009787 nucleotide binding site [chemical binding]; other site 271848009788 homotetrameric interface [polypeptide binding]; other site 271848009789 putative phosphate binding site [ion binding]; other site 271848009790 putative allosteric binding site; other site 271848009791 PUA domain; Region: PUA; cl00607 271848009792 CNP1-like family; Region: CNP1; pfam08750 271848009793 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 271848009794 putative active site [active] 271848009795 Ap4A binding site [chemical binding]; other site 271848009796 nudix motif; other site 271848009797 putative metal binding site [ion binding]; other site 271848009798 prolyl-tRNA synthetase; Provisional; Region: PRK09194 271848009799 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 271848009800 dimer interface [polypeptide binding]; other site 271848009801 motif 1; other site 271848009802 active site 271848009803 motif 2; other site 271848009804 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 271848009805 putative deacylase active site [active] 271848009806 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 271848009807 active site 271848009808 motif 3; other site 271848009809 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 271848009810 anticodon binding site; other site 271848009811 MarC family integral membrane protein; Region: MarC; cl00919 271848009812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848009813 active site 271848009814 signal recognition particle protein; Provisional; Region: PRK10867 271848009815 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 271848009816 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 271848009817 P loop; other site 271848009818 GTP binding site [chemical binding]; other site 271848009819 Signal peptide binding domain; Region: SRP_SPB; pfam02978 271848009820 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 271848009821 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271848009822 amidase catalytic site [active] 271848009823 Zn binding residues [ion binding]; other site 271848009824 substrate binding site [chemical binding]; other site 271848009825 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 271848009826 ATP cone domain; Region: ATP-cone; pfam03477 271848009827 Class I ribonucleotide reductase; Region: RNR_I; cd01679 271848009828 active site 271848009829 dimer interface [polypeptide binding]; other site 271848009830 catalytic residues [active] 271848009831 effector binding site; other site 271848009832 R2 peptide binding site; other site 271848009833 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 271848009834 dimer interface [polypeptide binding]; other site 271848009835 putative radical transfer pathway; other site 271848009836 diiron center [ion binding]; other site 271848009837 tyrosyl radical; other site 271848009838 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 271848009839 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848009840 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 271848009841 substrate binding site [chemical binding]; other site 271848009842 ATP binding site [chemical binding]; other site 271848009843 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 271848009844 dimer interface [polypeptide binding]; other site 271848009845 catalytic triad [active] 271848009846 peroxidatic and resolving cysteines [active] 271848009847 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 271848009848 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 271848009849 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 271848009850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848009851 S-adenosylmethionine binding site [chemical binding]; other site 271848009852 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 271848009853 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848009854 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848009855 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 271848009856 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 271848009857 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271848009858 carboxyltransferase (CT) interaction site; other site 271848009859 biotinylation site [posttranslational modification]; other site 271848009860 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 271848009861 active site 271848009862 trimer interface [polypeptide binding]; other site 271848009863 dimer interface [polypeptide binding]; other site 271848009864 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271848009865 catalytic residues [active] 271848009866 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 271848009867 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271848009868 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848009869 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848009870 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 271848009871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848009872 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 271848009873 RNB domain; Region: RNB; pfam00773 271848009874 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 271848009875 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 271848009876 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 271848009877 shikimate binding site; other site 271848009878 NAD(P) binding site [chemical binding]; other site 271848009879 Transglycosylase; Region: Transgly; cl07896 271848009880 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 271848009881 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 271848009882 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848009883 Helix-turn-helix domains; Region: HTH; cl00088 271848009884 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848009885 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 271848009886 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 271848009887 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 271848009888 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 271848009889 active site 271848009890 intersubunit interface [polypeptide binding]; other site 271848009891 catalytic residue [active] 271848009892 classical (c) SDRs; Region: SDR_c; cd05233 271848009893 NAD(P) binding site [chemical binding]; other site 271848009894 active site 271848009895 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 271848009896 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 271848009897 ligand binding site [chemical binding]; other site 271848009898 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 271848009899 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 271848009900 Walker A/P-loop; other site 271848009901 ATP binding site [chemical binding]; other site 271848009902 Q-loop/lid; other site 271848009903 ABC transporter signature motif; other site 271848009904 Walker B; other site 271848009905 D-loop; other site 271848009906 H-loop/switch region; other site 271848009907 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 271848009908 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848009909 TM-ABC transporter signature motif; other site 271848009910 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848009911 classical (c) SDRs; Region: SDR_c; cd05233 271848009912 NAD(P) binding site [chemical binding]; other site 271848009913 active site 271848009914 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 271848009915 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 271848009916 active site 271848009917 catalytic residues [active] 271848009918 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 271848009919 active site 271848009920 dimer interface [polypeptide binding]; other site 271848009921 Competence-damaged protein; Region: CinA; cl00666 271848009922 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 271848009923 tetramer interfaces [polypeptide binding]; other site 271848009924 binuclear metal-binding site [ion binding]; other site 271848009925 thiamine monophosphate kinase; Provisional; Region: PRK05731 271848009926 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 271848009927 ATP binding site [chemical binding]; other site 271848009928 dimerization interface [polypeptide binding]; other site 271848009929 malic enzyme; Reviewed; Region: PRK12862 271848009930 Malic enzyme, N-terminal domain; Region: malic; pfam00390 271848009931 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 271848009932 putative NAD(P) binding site [chemical binding]; other site 271848009933 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 271848009934 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 271848009935 active site 271848009936 barstar interaction site; other site 271848009937 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 271848009938 putative RNAase interaction site [polypeptide binding]; other site 271848009939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 271848009940 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 271848009941 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 271848009942 putative dimer interface [polypeptide binding]; other site 271848009943 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848009944 spermidine synthase; Provisional; Region: PRK00811 271848009945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848009946 transketolase; Reviewed; Region: PRK12753 271848009947 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 271848009948 TPP-binding site [chemical binding]; other site 271848009949 dimer interface [polypeptide binding]; other site 271848009950 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271848009951 PYR/PP interface [polypeptide binding]; other site 271848009952 dimer interface [polypeptide binding]; other site 271848009953 TPP binding site [chemical binding]; other site 271848009954 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848009955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848009956 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 271848009957 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 271848009958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009959 cyanate hydratase; Validated; Region: PRK02866 271848009960 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 271848009961 oligomer interface [polypeptide binding]; other site 271848009962 active site 271848009963 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 271848009964 active site clefts [active] 271848009965 zinc binding site [ion binding]; other site 271848009966 dimer interface [polypeptide binding]; other site 271848009967 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 271848009968 Helix-turn-helix domains; Region: HTH; cl00088 271848009969 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 271848009970 dimerization interface [polypeptide binding]; other site 271848009971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848009972 DNA-binding site [nucleotide binding]; DNA binding site 271848009973 FCD domain; Region: FCD; cl11656 271848009974 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 271848009975 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 271848009976 allantoicase; Provisional; Region: PRK13257 271848009977 Allantoicase repeat; Region: Allantoicase; pfam03561 271848009978 Allantoicase repeat; Region: Allantoicase; pfam03561 271848009979 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 271848009980 ferric uptake regulator; Provisional; Region: fur; PRK09462 271848009981 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 271848009982 metal binding site 2 [ion binding]; metal-binding site 271848009983 putative DNA binding helix; other site 271848009984 metal binding site 1 [ion binding]; metal-binding site 271848009985 dimer interface [polypeptide binding]; other site 271848009986 structural Zn2+ binding site [ion binding]; other site 271848009987 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 271848009988 dihydrodipicolinate reductase; Provisional; Region: PRK00048 271848009989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848009990 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 271848009991 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271848009992 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271848009993 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 271848009994 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 271848009995 HIGH motif; other site 271848009996 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271848009997 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848009998 active site 271848009999 KMSKS motif; other site 271848010000 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 271848010001 tRNA binding surface [nucleotide binding]; other site 271848010002 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 271848010003 Lipopolysaccharide-assembly; Region: LptE; cl01125 271848010004 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 271848010005 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 271848010006 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 271848010007 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 271848010008 putative catalytic cysteine [active] 271848010009 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 271848010010 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 271848010011 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848010012 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848010013 putative active site [active] 271848010014 Dehydratase family; Region: ILVD_EDD; cl00340 271848010015 6-phosphogluconate dehydratase; Region: edd; TIGR01196 271848010016 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 271848010017 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 271848010018 active site 271848010019 intersubunit interface [polypeptide binding]; other site 271848010020 catalytic residue [active] 271848010021 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 271848010022 GntP family permease; Region: GntP_permease; pfam02447 271848010023 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 271848010024 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 271848010025 ATP-binding site [chemical binding]; other site 271848010026 Gluconate-6-phosphate binding site [chemical binding]; other site 271848010027 adenylosuccinate lyase; Provisional; Region: PRK09285 271848010028 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 271848010029 tetramer interface [polypeptide binding]; other site 271848010030 active site 271848010031 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 271848010032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848010034 Helix-turn-helix domains; Region: HTH; cl00088 271848010035 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848010036 dimerization interface [polypeptide binding]; other site 271848010037 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 271848010038 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 271848010039 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 271848010040 NAD(P) binding site [chemical binding]; other site 271848010041 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 271848010042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848010043 substrate binding pocket [chemical binding]; other site 271848010044 membrane-bound complex binding site; other site 271848010045 hinge residues; other site 271848010046 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848010047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848010048 dimer interface [polypeptide binding]; other site 271848010049 conserved gate region; other site 271848010050 putative PBP binding loops; other site 271848010051 ABC-ATPase subunit interface; other site 271848010052 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848010053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848010054 dimer interface [polypeptide binding]; other site 271848010055 conserved gate region; other site 271848010056 putative PBP binding loops; other site 271848010057 ABC-ATPase subunit interface; other site 271848010058 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 271848010059 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 271848010060 Walker A/P-loop; other site 271848010061 ATP binding site [chemical binding]; other site 271848010062 Q-loop/lid; other site 271848010063 ABC transporter signature motif; other site 271848010064 Walker B; other site 271848010065 D-loop; other site 271848010066 H-loop/switch region; other site 271848010067 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 271848010068 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 271848010069 putative active site [active] 271848010070 putative dimer interface [polypeptide binding]; other site 271848010071 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 271848010072 active site 271848010073 substrate binding pocket [chemical binding]; other site 271848010074 dimer interface [polypeptide binding]; other site 271848010075 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 271848010076 OsmC-like protein; Region: OsmC; cl00767 271848010077 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 271848010078 23S rRNA interface [nucleotide binding]; other site 271848010079 L3 interface [polypeptide binding]; other site 271848010080 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 271848010081 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 271848010082 Cupin domain; Region: Cupin_2; cl09118 271848010083 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848010084 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 271848010085 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 271848010086 C-terminal domain interface [polypeptide binding]; other site 271848010087 GSH binding site (G-site) [chemical binding]; other site 271848010088 dimer interface [polypeptide binding]; other site 271848010089 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 271848010090 N-terminal domain interface [polypeptide binding]; other site 271848010091 dimer interface [polypeptide binding]; other site 271848010092 substrate binding pocket (H-site) [chemical binding]; other site 271848010093 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 271848010094 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 271848010095 C-terminal domain interface [polypeptide binding]; other site 271848010096 GSH binding site (G-site) [chemical binding]; other site 271848010097 dimer interface [polypeptide binding]; other site 271848010098 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 271848010099 N-terminal domain interface [polypeptide binding]; other site 271848010100 dimer interface [polypeptide binding]; other site 271848010101 substrate binding pocket (H-site) [chemical binding]; other site 271848010102 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 271848010103 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 271848010104 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 271848010105 active site 271848010106 HIGH motif; other site 271848010107 dimer interface [polypeptide binding]; other site 271848010108 KMSKS motif; other site 271848010109 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848010110 RNA binding surface [nucleotide binding]; other site 271848010111 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 271848010112 putative active site [active] 271848010113 dimerization interface [polypeptide binding]; other site 271848010114 putative tRNAtyr binding site [nucleotide binding]; other site 271848010115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271848010116 catalytic core [active] 271848010117 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 271848010118 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 271848010119 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 271848010120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848010121 Walker A motif; other site 271848010122 ATP binding site [chemical binding]; other site 271848010123 Walker B motif; other site 271848010124 arginine finger; other site 271848010125 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 271848010126 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 271848010127 RuvA N terminal domain; Region: RuvA_N; pfam01330 271848010128 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 271848010129 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 271848010130 active site 271848010131 putative DNA-binding cleft [nucleotide binding]; other site 271848010132 dimer interface [polypeptide binding]; other site 271848010133 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 271848010134 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 271848010135 purine monophosphate binding site [chemical binding]; other site 271848010136 dimer interface [polypeptide binding]; other site 271848010137 putative catalytic residues [active] 271848010138 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 271848010139 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 271848010140 Helix-turn-helix domains; Region: HTH; cl00088 271848010141 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 271848010142 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 271848010143 FMN binding site [chemical binding]; other site 271848010144 active site 271848010145 catalytic residues [active] 271848010146 substrate binding site [chemical binding]; other site 271848010147 hypothetical protein; Provisional; Region: PRK06996 271848010148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010149 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 271848010150 proline aminopeptidase P II; Provisional; Region: PRK10879 271848010151 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 271848010152 active site 271848010153 putative glutathione S-transferase; Provisional; Region: PRK10357 271848010154 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 271848010155 putative C-terminal domain interface [polypeptide binding]; other site 271848010156 putative GSH binding site (G-site) [chemical binding]; other site 271848010157 putative dimer interface [polypeptide binding]; other site 271848010158 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 271848010159 dimer interface [polypeptide binding]; other site 271848010160 N-terminal domain interface [polypeptide binding]; other site 271848010161 putative substrate binding pocket (H-site) [chemical binding]; other site 271848010162 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 271848010163 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 271848010164 active site 271848010165 FMN binding site [chemical binding]; other site 271848010166 substrate binding site [chemical binding]; other site 271848010167 3Fe-4S cluster binding site [ion binding]; other site 271848010168 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 271848010169 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 271848010170 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 271848010171 nudix motif; other site 271848010172 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 271848010173 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 271848010174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010175 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 271848010176 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 271848010177 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 271848010178 Helix-turn-helix domains; Region: HTH; cl00088 271848010179 WYL domain; Region: WYL; cl14852 271848010180 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 271848010181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848010182 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 271848010183 THUMP domain; Region: THUMP; cl12076 271848010184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848010185 Site-specific recombinase; Region: SpecificRecomb; cl15411 271848010186 Protein of unknown function (DUF330); Region: DUF330; cl01135 271848010187 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 271848010188 mce related protein; Region: MCE; pfam02470 271848010189 mce related protein; Region: MCE; pfam02470 271848010190 Paraquat-inducible protein A; Region: PqiA; pfam04403 271848010191 Paraquat-inducible protein A; Region: PqiA; pfam04403 271848010192 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271848010193 YceI-like domain; Region: YceI; cl01001 271848010194 YceI-like domain; Region: YceI; cl01001 271848010195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010196 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848010197 putative substrate translocation pore; other site 271848010198 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 271848010199 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 271848010200 Protein export membrane protein; Region: SecD_SecF; cl14618 271848010201 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 271848010202 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 271848010203 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 271848010204 Protein export membrane protein; Region: SecD_SecF; cl14618 271848010205 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 271848010206 Preprotein translocase subunit; Region: YajC; cl00806 271848010207 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 271848010208 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 271848010209 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 271848010210 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 271848010211 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 271848010212 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 271848010213 generic binding surface II; other site 271848010214 ssDNA binding site; other site 271848010215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848010216 ATP binding site [chemical binding]; other site 271848010217 putative Mg++ binding site [ion binding]; other site 271848010218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848010219 nucleotide binding region [chemical binding]; other site 271848010220 ATP-binding site [chemical binding]; other site 271848010221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848010222 Helix-turn-helix domains; Region: HTH; cl00088 271848010223 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 271848010224 dimerization interface [polypeptide binding]; other site 271848010225 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 271848010226 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 271848010227 dimer interface [polypeptide binding]; other site 271848010228 active site 271848010229 heme binding site [chemical binding]; other site 271848010230 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 271848010231 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 271848010232 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 271848010233 dimerization interface [polypeptide binding]; other site 271848010234 DPS ferroxidase diiron center [ion binding]; other site 271848010235 ion pore; other site 271848010236 UbiA prenyltransferase family; Region: UbiA; cl00337 271848010237 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 271848010238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010239 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 271848010240 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848010241 catalytic residue [active] 271848010242 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 271848010243 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271848010244 Cysteine-rich domain; Region: CCG; pfam02754 271848010245 Cysteine-rich domain; Region: CCG; pfam02754 271848010246 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 271848010247 FAD binding domain; Region: FAD_binding_4; pfam01565 271848010248 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 271848010249 FAD binding domain; Region: FAD_binding_4; pfam01565 271848010250 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 271848010251 FAD binding domain; Region: FAD_binding_4; pfam01565 271848010252 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 271848010253 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 271848010254 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 271848010255 heme-binding site [chemical binding]; other site 271848010256 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 271848010257 FAD binding pocket [chemical binding]; other site 271848010258 FAD binding motif [chemical binding]; other site 271848010259 phosphate binding motif [ion binding]; other site 271848010260 beta-alpha-beta structure motif; other site 271848010261 NAD binding pocket [chemical binding]; other site 271848010262 Heme binding pocket [chemical binding]; other site 271848010263 NeuB family; Region: NeuB; cl00496 271848010264 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271848010265 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 271848010266 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 271848010267 Predicted amidohydrolase [General function prediction only]; Region: COG0388 271848010268 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 271848010269 putative active site [active] 271848010270 catalytic triad [active] 271848010271 dimer interface [polypeptide binding]; other site 271848010272 TIGR02099 family protein; Region: TIGR02099 271848010273 AsmA-like C-terminal region; Region: AsmA_2; cl15864 271848010274 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271848010275 metal binding triad; other site 271848010276 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271848010277 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271848010278 metal binding triad; other site 271848010279 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271848010280 recombination and repair protein; Provisional; Region: PRK10869 271848010281 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 271848010282 Walker A/P-loop; other site 271848010283 ATP binding site [chemical binding]; other site 271848010284 Q-loop/lid; other site 271848010285 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 271848010286 ABC transporter signature motif; other site 271848010287 Walker B; other site 271848010288 D-loop; other site 271848010289 H-loop/switch region; other site 271848010290 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 271848010291 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 271848010292 Helix-turn-helix domains; Region: HTH; cl00088 271848010293 ferrochelatase; Reviewed; Region: hemH; PRK00035 271848010294 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 271848010295 C-terminal domain interface [polypeptide binding]; other site 271848010296 active site 271848010297 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 271848010298 active site 271848010299 N-terminal domain interface [polypeptide binding]; other site 271848010300 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848010301 RNA binding surface [nucleotide binding]; other site 271848010302 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 271848010303 dimer interface [polypeptide binding]; other site 271848010304 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 271848010305 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271848010306 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 271848010307 chaperone protein DnaJ; Provisional; Region: PRK10767 271848010308 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271848010309 HSP70 interaction site [polypeptide binding]; other site 271848010310 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 271848010311 Zn binding sites [ion binding]; other site 271848010312 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 271848010313 dimer interface [polypeptide binding]; other site 271848010314 chorismate binding enzyme; Region: Chorismate_bind; cl10555 271848010315 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 271848010316 homodimer interface [polypeptide binding]; other site 271848010317 substrate-cofactor binding pocket; other site 271848010318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848010319 catalytic residue [active] 271848010320 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 271848010321 oligomerization interface [polypeptide binding]; other site 271848010322 active site 271848010323 metal binding site [ion binding]; metal-binding site 271848010324 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 271848010325 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 271848010326 Substrate-binding site [chemical binding]; other site 271848010327 Substrate specificity [chemical binding]; other site 271848010328 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 271848010329 catalytic center binding site [active] 271848010330 ATP binding site [chemical binding]; other site 271848010331 poly(A) polymerase; Region: pcnB; TIGR01942 271848010332 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 271848010333 active site 271848010334 NTP binding site [chemical binding]; other site 271848010335 metal binding triad [ion binding]; metal-binding site 271848010336 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 271848010337 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 271848010338 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 271848010339 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848010340 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848010341 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 271848010342 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 271848010343 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 271848010344 dimerization interface [polypeptide binding]; other site 271848010345 putative ATP binding site [chemical binding]; other site 271848010346 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848010347 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848010348 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 271848010349 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 271848010350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848010351 ATP binding site [chemical binding]; other site 271848010352 Mg2+ binding site [ion binding]; other site 271848010353 G-X-G motif; other site 271848010354 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 271848010355 ATP binding site [chemical binding]; other site 271848010356 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 271848010357 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271848010358 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271848010359 TIGR03442 family protein; Region: TIGR03442 271848010360 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 271848010361 putative active site [active] 271848010362 putative dimer interface [polypeptide binding]; other site 271848010363 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 271848010364 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 271848010365 Substrate binding site; other site 271848010366 Cupin domain; Region: Cupin_2; cl09118 271848010367 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 271848010368 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848010369 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 271848010370 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848010371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848010372 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848010373 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848010374 digalactosyldiacylglycerol synthase; Region: PLN02846 271848010375 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848010376 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 271848010377 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 271848010378 NADP-binding site; other site 271848010379 homotetramer interface [polypeptide binding]; other site 271848010380 substrate binding site [chemical binding]; other site 271848010381 homodimer interface [polypeptide binding]; other site 271848010382 active site 271848010383 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 271848010384 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 271848010385 NADP-binding site; other site 271848010386 homotetramer interface [polypeptide binding]; other site 271848010387 substrate binding site [chemical binding]; other site 271848010388 homodimer interface [polypeptide binding]; other site 271848010389 active site 271848010390 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848010391 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848010392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848010393 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 271848010394 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 271848010395 Walker A/P-loop; other site 271848010396 ATP binding site [chemical binding]; other site 271848010397 Q-loop/lid; other site 271848010398 ABC transporter signature motif; other site 271848010399 Walker B; other site 271848010400 D-loop; other site 271848010401 H-loop/switch region; other site 271848010402 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848010403 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 271848010404 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 271848010405 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 271848010406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010407 NAD(P) binding site [chemical binding]; other site 271848010408 active site 271848010409 Sulfatase; Region: Sulfatase; cl10460 271848010410 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848010411 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848010412 active site 271848010413 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848010414 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848010415 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 271848010416 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848010417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848010418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010419 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 271848010420 Enoylreductase; Region: PKS_ER; smart00829 271848010421 NAD(P) binding site [chemical binding]; other site 271848010422 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 271848010423 putative NADP binding site [chemical binding]; other site 271848010424 active site 271848010425 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848010426 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 271848010427 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 271848010428 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 271848010429 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848010430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848010431 catalytic residue [active] 271848010432 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848010433 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 271848010434 putative carbohydrate binding site [chemical binding]; other site 271848010435 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 271848010436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848010437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848010438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848010439 CoA-binding domain; Region: CoA_binding_3; pfam13727 271848010440 Bacterial sugar transferase; Region: Bac_transf; cl00939 271848010441 polysaccharide export protein Wza; Provisional; Region: PRK15078 271848010442 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848010443 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271848010444 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 271848010445 active site 271848010446 Chain length determinant protein; Region: Wzz; cl15801 271848010447 tyrosine kinase; Provisional; Region: PRK11519 271848010448 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region; Region: Glyco_transf_54; pfam04666 271848010449 Chain length determinant protein; Region: Wzz; cl15801 271848010450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848010451 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 271848010452 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 271848010453 trimer interface [polypeptide binding]; other site 271848010454 active site 271848010455 substrate binding site [chemical binding]; other site 271848010456 CoA binding site [chemical binding]; other site 271848010457 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848010458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848010459 NeuB family; Region: NeuB; cl00496 271848010460 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271848010461 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848010462 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 271848010463 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 271848010464 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 271848010465 putative active site [active] 271848010466 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 271848010467 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 271848010468 active site 271848010469 tetramer interface; other site 271848010470 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 271848010471 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 271848010472 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848010473 putative di-iron ligands [ion binding]; other site 271848010474 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 271848010475 Proline dehydrogenase; Region: Pro_dh; cl03282 271848010476 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 271848010477 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848010478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848010479 catalytic residue [active] 271848010480 EamA-like transporter family; Region: EamA; cl01037 271848010481 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271848010482 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 271848010483 Tetratricopeptide repeat; Region: TPR_6; pfam13174 271848010484 Tetratricopeptide repeat; Region: TPR_6; pfam13174 271848010485 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 271848010486 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848010487 ligand binding site [chemical binding]; other site 271848010488 translocation protein TolB; Provisional; Region: tolB; PRK02889 271848010489 TolB amino-terminal domain; Region: TolB_N; cl00639 271848010490 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271848010491 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271848010492 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271848010493 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271848010494 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 271848010495 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271848010496 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271848010497 active site 271848010498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010499 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 271848010500 NAD(P) binding site [chemical binding]; other site 271848010501 active site 271848010502 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 271848010503 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 271848010504 dimer interface [polypeptide binding]; other site 271848010505 active site 271848010506 glycine-pyridoxal phosphate binding site [chemical binding]; other site 271848010507 folate binding site [chemical binding]; other site 271848010508 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 271848010509 ATP cone domain; Region: ATP-cone; pfam03477 271848010510 Type II transport protein GspH; Region: GspH; pfam12019 271848010511 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 271848010512 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 271848010513 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 271848010514 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 271848010515 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 271848010516 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 271848010517 dimer interface [polypeptide binding]; other site 271848010518 decamer (pentamer of dimers) interface [polypeptide binding]; other site 271848010519 catalytic triad [active] 271848010520 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 271848010521 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848010522 FAD binding site [chemical binding]; other site 271848010523 substrate binding pocket [chemical binding]; other site 271848010524 catalytic base [active] 271848010525 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848010526 Helix-turn-helix domains; Region: HTH; cl00088 271848010527 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 271848010528 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 271848010529 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848010530 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 271848010531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010532 benzoate transport; Region: 2A0115; TIGR00895 271848010533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010534 putative substrate translocation pore; other site 271848010535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010536 Cupin domain; Region: Cupin_2; cl09118 271848010537 fumarylacetoacetase; Region: PLN02856 271848010538 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 271848010539 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848010540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010541 putative substrate translocation pore; other site 271848010542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010543 putative substrate translocation pore; other site 271848010544 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 271848010545 putative FMN binding site [chemical binding]; other site 271848010546 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 271848010547 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271848010548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848010550 Helix-turn-helix domains; Region: HTH; cl00088 271848010551 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848010552 putative effector binding pocket; other site 271848010553 dimerization interface [polypeptide binding]; other site 271848010554 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 271848010555 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848010556 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848010557 catalytic residue [active] 271848010558 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848010559 EamA-like transporter family; Region: EamA; cl01037 271848010560 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271848010561 EamA-like transporter family; Region: EamA; cl01037 271848010562 major facilitator superfamily transporter; Provisional; Region: PRK05122 271848010563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010564 putative substrate translocation pore; other site 271848010565 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 271848010566 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 271848010567 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 271848010568 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 271848010569 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 271848010570 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 271848010571 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271848010572 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271848010573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848010574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 271848010575 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 271848010576 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848010577 N-terminal plug; other site 271848010578 ligand-binding site [chemical binding]; other site 271848010579 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 271848010580 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271848010581 Walker A/P-loop; other site 271848010582 ATP binding site [chemical binding]; other site 271848010583 Q-loop/lid; other site 271848010584 ABC transporter signature motif; other site 271848010585 Walker B; other site 271848010586 D-loop; other site 271848010587 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 271848010588 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 271848010589 putative ligand binding residues [chemical binding]; other site 271848010590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 271848010591 ABC-ATPase subunit interface; other site 271848010592 dimer interface [polypeptide binding]; other site 271848010593 putative PBP binding regions; other site 271848010594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848010595 Helix-turn-helix domains; Region: HTH; cl00088 271848010596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848010597 dimerization interface [polypeptide binding]; other site 271848010598 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 271848010599 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 271848010600 putative catalytic residue [active] 271848010601 NMT1-like family; Region: NMT1_2; cl15260 271848010602 BON domain; Region: BON; cl02771 271848010603 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 271848010604 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 271848010605 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 271848010606 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 271848010607 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848010608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010609 putative substrate translocation pore; other site 271848010610 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 271848010611 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 271848010612 putative active site [active] 271848010613 catalytic site [active] 271848010614 putative metal binding site [ion binding]; other site 271848010615 LysE type translocator; Region: LysE; cl00565 271848010616 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848010617 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 271848010618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848010619 non-specific DNA binding site [nucleotide binding]; other site 271848010620 salt bridge; other site 271848010621 sequence-specific DNA binding site [nucleotide binding]; other site 271848010622 Cupin domain; Region: Cupin_2; cl09118 271848010623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848010624 Helix-turn-helix domains; Region: HTH; cl00088 271848010625 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 271848010626 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 271848010627 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 271848010628 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 271848010629 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 271848010630 putative NAD(P) binding site [chemical binding]; other site 271848010631 Helix-turn-helix domains; Region: HTH; cl00088 271848010632 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848010633 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848010634 Integrase core domain; Region: rve; cl01316 271848010635 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848010636 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848010637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848010638 Helix-turn-helix domains; Region: HTH; cl00088 271848010639 Predicted transcriptional regulator [Transcription]; Region: COG2378 271848010640 WYL domain; Region: WYL; cl14852 271848010641 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 271848010642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848010643 Family description; Region: UvrD_C_2; cl15862 271848010644 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 271848010645 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 271848010646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848010647 motif II; other site 271848010648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848010649 Helix-turn-helix domains; Region: HTH; cl00088 271848010650 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848010651 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848010652 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848010653 Integrase core domain; Region: rve; cl01316 271848010654 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848010655 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848010656 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848010657 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848010658 Integrase core domain; Region: rve; cl01316 271848010659 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848010660 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848010661 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848010662 Integrase core domain; Region: rve; cl01316 271848010663 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848010664 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848010665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848010666 Helix-turn-helix domains; Region: HTH; cl00088 271848010667 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848010668 HTH-like domain; Region: HTH_21; pfam13276 271848010669 Integrase core domain; Region: rve; cl01316 271848010670 Integrase core domain; Region: rve_3; cl15866 271848010671 Helix-turn-helix domains; Region: HTH; cl00088 271848010672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848010673 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 271848010674 oligomerisation interface [polypeptide binding]; other site 271848010675 mobile loop; other site 271848010676 roof hairpin; other site 271848010677 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 271848010678 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 271848010679 ring oligomerisation interface [polypeptide binding]; other site 271848010680 ATP/Mg binding site [chemical binding]; other site 271848010681 stacking interactions; other site 271848010682 hinge regions; other site 271848010683 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 271848010684 dimer interface [polypeptide binding]; other site 271848010685 substrate binding site [chemical binding]; other site 271848010686 ATP binding site [chemical binding]; other site 271848010687 Rubredoxin [Energy production and conversion]; Region: COG1773 271848010688 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 271848010689 iron binding site [ion binding]; other site 271848010690 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 271848010691 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 271848010692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848010693 active site 271848010694 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 271848010695 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271848010696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010697 dihydroorotase; Provisional; Region: PRK07627 271848010698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848010699 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 271848010700 active site 271848010701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271848010702 putative acyl-acceptor binding pocket; other site 271848010703 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 271848010704 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 271848010705 active site 271848010706 metal binding site [ion binding]; metal-binding site 271848010707 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 271848010708 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 271848010709 NAD binding site [chemical binding]; other site 271848010710 substrate binding site [chemical binding]; other site 271848010711 homodimer interface [polypeptide binding]; other site 271848010712 active site 271848010713 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 271848010714 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 271848010715 substrate binding site; other site 271848010716 tetramer interface; other site 271848010717 Cupin domain; Region: Cupin_2; cl09118 271848010718 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 271848010719 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 271848010720 NADP binding site [chemical binding]; other site 271848010721 active site 271848010722 putative substrate binding site [chemical binding]; other site 271848010723 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848010724 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 271848010725 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 271848010726 Walker A/P-loop; other site 271848010727 ATP binding site [chemical binding]; other site 271848010728 Q-loop/lid; other site 271848010729 ABC transporter signature motif; other site 271848010730 Walker B; other site 271848010731 D-loop; other site 271848010732 H-loop/switch region; other site 271848010733 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 271848010734 putative carbohydrate binding site [chemical binding]; other site 271848010735 OpgC protein; Region: OpgC_C; cl00792 271848010736 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271848010737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848010738 extended (e) SDRs; Region: SDR_e; cd08946 271848010739 NAD(P) binding site [chemical binding]; other site 271848010740 active site 271848010741 substrate binding site [chemical binding]; other site 271848010742 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 271848010743 Probable Catalytic site; other site 271848010744 metal-binding site 271848010745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848010746 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848010747 active site 271848010748 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271848010749 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 271848010750 Probable Catalytic site; other site 271848010751 metal-binding site 271848010752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848010753 active site 271848010754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848010755 active site 271848010756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848010757 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848010758 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 271848010759 putative NAD(P) binding site [chemical binding]; other site 271848010760 active site 271848010761 putative substrate binding site [chemical binding]; other site 271848010762 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 271848010763 Mg++ binding site [ion binding]; other site 271848010764 putative catalytic motif [active] 271848010765 putative substrate binding site [chemical binding]; other site 271848010766 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 271848010767 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 271848010768 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 271848010769 NAD(P) binding site [chemical binding]; other site 271848010770 homodimer interface [polypeptide binding]; other site 271848010771 substrate binding site [chemical binding]; other site 271848010772 active site 271848010773 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 271848010774 Mg++ binding site [ion binding]; other site 271848010775 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 271848010776 putative catalytic motif [active] 271848010777 UDP-glucose 4-epimerase; Region: PLN02240 271848010778 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 271848010779 NAD binding site [chemical binding]; other site 271848010780 homodimer interface [polypeptide binding]; other site 271848010781 active site 271848010782 substrate binding site [chemical binding]; other site 271848010783 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 271848010784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848010785 putative ADP-binding pocket [chemical binding]; other site 271848010786 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271848010787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848010788 active site 271848010789 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 271848010790 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 271848010791 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 271848010792 active site 271848010793 substrate binding site [chemical binding]; other site 271848010794 metal binding site [ion binding]; metal-binding site 271848010795 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848010796 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 271848010797 putative active site [active] 271848010798 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 271848010799 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 271848010800 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 271848010801 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848010802 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 271848010803 UreF; Region: UreF; pfam01730 271848010804 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 271848010805 dimer interface [polypeptide binding]; other site 271848010806 catalytic residues [active] 271848010807 urease subunit alpha; Reviewed; Region: ureC; PRK13207 271848010808 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 271848010809 subunit interactions [polypeptide binding]; other site 271848010810 active site 271848010811 flap region; other site 271848010812 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 271848010813 gamma-beta subunit interface [polypeptide binding]; other site 271848010814 alpha-beta subunit interface [polypeptide binding]; other site 271848010815 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 271848010816 alpha-gamma subunit interface [polypeptide binding]; other site 271848010817 beta-gamma subunit interface [polypeptide binding]; other site 271848010818 UreD urease accessory protein; Region: UreD; cl00530 271848010819 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 271848010820 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271848010821 Walker A/P-loop; other site 271848010822 ATP binding site [chemical binding]; other site 271848010823 Q-loop/lid; other site 271848010824 ABC transporter signature motif; other site 271848010825 Walker B; other site 271848010826 D-loop; other site 271848010827 H-loop/switch region; other site 271848010828 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 271848010829 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 271848010830 Walker A/P-loop; other site 271848010831 ATP binding site [chemical binding]; other site 271848010832 Q-loop/lid; other site 271848010833 ABC transporter signature motif; other site 271848010834 Walker B; other site 271848010835 D-loop; other site 271848010836 H-loop/switch region; other site 271848010837 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 271848010838 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848010839 TM-ABC transporter signature motif; other site 271848010840 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848010841 TM-ABC transporter signature motif; other site 271848010842 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271848010843 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 271848010844 putative ligand binding site [chemical binding]; other site 271848010845 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 271848010846 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848010847 inhibitor-cofactor binding pocket; inhibition site 271848010848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848010849 catalytic residue [active] 271848010850 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848010851 active site residue [active] 271848010852 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 271848010853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848010854 S-adenosylmethionine binding site [chemical binding]; other site 271848010855 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 271848010856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848010857 FeS/SAM binding site; other site 271848010858 HemN C-terminal domain; Region: HemN_C; pfam06969 271848010859 Flagellin N-methylase; Region: FliB; cl00497 271848010860 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 271848010861 Bacitracin resistance protein BacA; Region: BacA; cl00858 271848010862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848010863 S-adenosylmethionine binding site [chemical binding]; other site 271848010864 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 271848010865 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 271848010866 NADP binding site [chemical binding]; other site 271848010867 dimer interface [polypeptide binding]; other site 271848010868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848010869 Helix-turn-helix domains; Region: HTH; cl00088 271848010870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848010871 dimerization interface [polypeptide binding]; other site 271848010872 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 271848010873 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848010874 active site 271848010875 catalytic triad [active] 271848010876 calcium binding site [ion binding]; other site 271848010877 CrcB-like protein; Region: CRCB; cl09114 271848010878 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 271848010879 YGGT family; Region: YGGT; cl00508 271848010880 YGGT family; Region: YGGT; cl00508 271848010881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010882 haloacid dehalogenase-like hydrolase; Provisional; Region: PLN03243 271848010883 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 271848010884 serine racemase; Region: PLN02970 271848010885 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271848010886 tetramer interface [polypeptide binding]; other site 271848010887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848010888 catalytic residue [active] 271848010889 LysE type translocator; Region: LysE; cl00565 271848010890 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 271848010891 murein transglycosylase C; Provisional; Region: mltC; PRK11671 271848010892 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271848010893 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848010894 catalytic residue [active] 271848010895 aminotransferase; Validated; Region: PRK07337 271848010896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848010897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848010898 homodimer interface [polypeptide binding]; other site 271848010899 catalytic residue [active] 271848010900 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 271848010901 putative RNA binding site [nucleotide binding]; other site 271848010902 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 271848010903 homopentamer interface [polypeptide binding]; other site 271848010904 active site 271848010905 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 271848010906 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 271848010907 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 271848010908 dimerization interface [polypeptide binding]; other site 271848010909 active site 271848010910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848010911 nucleotide binding region [chemical binding]; other site 271848010912 ATP-binding site [chemical binding]; other site 271848010913 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848010914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848010915 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848010916 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848010917 HTH-like domain; Region: HTH_21; pfam13276 271848010918 Integrase core domain; Region: rve; cl01316 271848010919 Integrase core domain; Region: rve_3; cl15866 271848010920 Helix-turn-helix domains; Region: HTH; cl00088 271848010921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848010922 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848010923 Fic/DOC family; Region: Fic; cl00960 271848010924 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 271848010925 Lumazine binding domain; Region: Lum_binding; pfam00677 271848010926 Lumazine binding domain; Region: Lum_binding; pfam00677 271848010927 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 271848010928 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 271848010929 catalytic motif [active] 271848010930 Zn binding site [ion binding]; other site 271848010931 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 271848010932 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 271848010933 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848010934 inhibitor-cofactor binding pocket; inhibition site 271848010935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848010936 catalytic residue [active] 271848010937 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 271848010938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010939 putative substrate translocation pore; other site 271848010940 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 271848010941 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 271848010942 Walker A/P-loop; other site 271848010943 ATP binding site [chemical binding]; other site 271848010944 Q-loop/lid; other site 271848010945 ABC transporter signature motif; other site 271848010946 Walker B; other site 271848010947 D-loop; other site 271848010948 H-loop/switch region; other site 271848010949 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848010950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848010951 dimer interface [polypeptide binding]; other site 271848010952 conserved gate region; other site 271848010953 putative PBP binding loops; other site 271848010954 ABC-ATPase subunit interface; other site 271848010955 cystine transporter subunit; Provisional; Region: PRK11260 271848010956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848010957 substrate binding pocket [chemical binding]; other site 271848010958 membrane-bound complex binding site; other site 271848010959 hinge residues; other site 271848010960 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 271848010961 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 271848010962 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848010963 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848010964 putative active site [active] 271848010965 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 271848010966 putative active site [active] 271848010967 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 271848010968 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 271848010969 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 271848010970 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 271848010971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848010972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848010973 dimer interface [polypeptide binding]; other site 271848010974 conserved gate region; other site 271848010975 putative PBP binding loops; other site 271848010976 ABC-ATPase subunit interface; other site 271848010977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848010978 dimer interface [polypeptide binding]; other site 271848010979 conserved gate region; other site 271848010980 putative PBP binding loops; other site 271848010981 ABC-ATPase subunit interface; other site 271848010982 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 271848010983 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 271848010984 Walker A/P-loop; other site 271848010985 ATP binding site [chemical binding]; other site 271848010986 Q-loop/lid; other site 271848010987 ABC transporter signature motif; other site 271848010988 Walker B; other site 271848010989 D-loop; other site 271848010990 H-loop/switch region; other site 271848010991 Predicted membrane protein [Function unknown]; Region: COG2860 271848010992 UPF0126 domain; Region: UPF0126; pfam03458 271848010993 UPF0126 domain; Region: UPF0126; pfam03458 271848010994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 271848010995 Smr domain; Region: Smr; cl02619 271848010996 thioredoxin reductase; Provisional; Region: PRK10262 271848010997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848010998 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 271848010999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848011000 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 271848011001 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 271848011002 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 271848011003 recombination factor protein RarA; Reviewed; Region: PRK13342 271848011004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848011005 Walker A motif; other site 271848011006 ATP binding site [chemical binding]; other site 271848011007 Walker B motif; other site 271848011008 arginine finger; other site 271848011009 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 271848011010 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 271848011011 seryl-tRNA synthetase; Provisional; Region: PRK05431 271848011012 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 271848011013 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 271848011014 dimer interface [polypeptide binding]; other site 271848011015 active site 271848011016 motif 1; other site 271848011017 motif 2; other site 271848011018 motif 3; other site 271848011019 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848011020 septum formation inhibitor; Reviewed; Region: PRK01973 271848011021 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 271848011022 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 271848011023 cell division inhibitor MinD; Provisional; Region: PRK10818 271848011024 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 271848011025 Switch I; other site 271848011026 Switch II; other site 271848011027 Septum formation topological specificity factor MinE; Region: MinE; cl00538 271848011028 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 271848011029 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 271848011030 putative ion selectivity filter; other site 271848011031 putative pore gating glutamate residue; other site 271848011032 putative H+/Cl- coupling transport residue; other site 271848011033 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848011034 putative active site [active] 271848011035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011036 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848011037 putative substrate translocation pore; other site 271848011038 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 271848011039 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 271848011040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848011041 FeS/SAM binding site; other site 271848011042 HemN C-terminal domain; Region: HemN_C; pfam06969 271848011043 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 271848011044 active site 271848011045 dimerization interface [polypeptide binding]; other site 271848011046 ribonuclease PH; Reviewed; Region: rph; PRK00173 271848011047 Ribonuclease PH; Region: RNase_PH_bact; cd11362 271848011048 hexamer interface [polypeptide binding]; other site 271848011049 active site 271848011050 hypothetical protein; Provisional; Region: PRK11820 271848011051 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 271848011052 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 271848011053 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 271848011054 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 271848011055 catalytic site [active] 271848011056 G-X2-G-X-G-K; other site 271848011057 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 271848011058 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 271848011059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271848011060 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 271848011061 synthetase active site [active] 271848011062 NTP binding site [chemical binding]; other site 271848011063 metal binding site [ion binding]; metal-binding site 271848011064 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 271848011065 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 271848011066 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 271848011067 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 271848011068 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 271848011069 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848011070 trimer interface [polypeptide binding]; other site 271848011071 eyelet of channel; other site 271848011072 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 271848011073 DNA-binding site [nucleotide binding]; DNA binding site 271848011074 RNA-binding motif; other site 271848011075 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 271848011076 active site 271848011077 catalytic site [active] 271848011078 substrate binding site [chemical binding]; other site 271848011079 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 271848011080 GIY-YIG motif/motif A; other site 271848011081 active site 271848011082 catalytic site [active] 271848011083 putative DNA binding site [nucleotide binding]; other site 271848011084 metal binding site [ion binding]; metal-binding site 271848011085 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 271848011086 Chorismate mutase type II; Region: CM_2; cl00693 271848011087 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 271848011088 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 271848011089 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848011090 N-terminal plug; other site 271848011091 ligand-binding site [chemical binding]; other site 271848011092 BNR repeat-like domain; Region: BNR_2; pfam13088 271848011093 BNR repeat-like domain; Region: BNR_2; pfam13088 271848011094 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271848011095 catalytic residues [active] 271848011096 fructose-1,6-bisphosphatase family protein; Region: PLN02628 271848011097 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 271848011098 AMP binding site [chemical binding]; other site 271848011099 metal binding site [ion binding]; metal-binding site 271848011100 active site 271848011101 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 271848011102 Helix-turn-helix domains; Region: HTH; cl00088 271848011103 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 271848011104 putative dimerization interface [polypeptide binding]; other site 271848011105 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 271848011106 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 271848011107 THF binding site; other site 271848011108 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 271848011109 substrate binding site [chemical binding]; other site 271848011110 THF binding site; other site 271848011111 zinc-binding site [ion binding]; other site 271848011112 aminopeptidase N; Provisional; Region: pepN; PRK14015 271848011113 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 271848011114 active site 271848011115 Zn binding site [ion binding]; other site 271848011116 Predicted membrane protein [Function unknown]; Region: COG2119 271848011117 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 271848011118 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 271848011119 guanine deaminase; Provisional; Region: PRK09228 271848011120 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848011121 active site 271848011122 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 271848011123 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 271848011124 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 271848011125 active site 271848011126 purine riboside binding site [chemical binding]; other site 271848011127 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 271848011128 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 271848011129 XdhC Rossmann domain; Region: XdhC_C; pfam13478 271848011130 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 271848011131 amidase; Provisional; Region: PRK07056 271848011132 Amidase; Region: Amidase; cl11426 271848011133 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 271848011134 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 271848011135 catalytic triad [active] 271848011136 citrate-proton symporter; Provisional; Region: PRK15075 271848011137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011138 putative substrate translocation pore; other site 271848011139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848011140 TPR motif; other site 271848011141 binding surface 271848011142 TPR repeat; Region: TPR_11; pfam13414 271848011143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848011144 binding surface 271848011145 TPR motif; other site 271848011146 TPR repeat; Region: TPR_11; pfam13414 271848011147 Tetratricopeptide repeat; Region: TPR_12; pfam13424 271848011148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848011149 binding surface 271848011150 TPR motif; other site 271848011151 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848011152 hypothetical protein; Provisional; Region: PRK06184 271848011153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011154 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 271848011155 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 271848011156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848011157 catalytic loop [active] 271848011158 iron binding site [ion binding]; other site 271848011159 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 271848011160 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271848011161 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 271848011162 [4Fe-4S] binding site [ion binding]; other site 271848011163 molybdopterin cofactor binding site; other site 271848011164 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 271848011165 molybdopterin cofactor binding site; other site 271848011166 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 271848011167 putative dimer interface [polypeptide binding]; other site 271848011168 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 271848011169 SLBB domain; Region: SLBB; pfam10531 271848011170 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 271848011171 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 271848011172 putative dimer interface [polypeptide binding]; other site 271848011173 [2Fe-2S] cluster binding site [ion binding]; other site 271848011174 Helix-turn-helix domains; Region: HTH; cl00088 271848011175 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 271848011176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848011177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848011178 phosphoglycolate phosphatase; Provisional; Region: PRK13222 271848011179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848011180 motif II; other site 271848011181 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 271848011182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848011183 S-adenosylmethionine binding site [chemical binding]; other site 271848011184 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848011185 ligand binding site [chemical binding]; other site 271848011186 DNA gyrase subunit A; Validated; Region: PRK05560 271848011187 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 271848011188 CAP-like domain; other site 271848011189 active site 271848011190 primary dimer interface [polypeptide binding]; other site 271848011191 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011192 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011193 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011195 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011196 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011197 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 271848011198 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 271848011199 homodimer interface [polypeptide binding]; other site 271848011200 substrate-cofactor binding pocket; other site 271848011201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011202 catalytic residue [active] 271848011203 Chorismate mutase type II; Region: CM_2; cl00693 271848011204 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 271848011205 Prephenate dehydratase; Region: PDT; pfam00800 271848011206 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 271848011207 putative L-Phe binding site [chemical binding]; other site 271848011208 bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK11861 271848011209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011210 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 271848011211 hinge; other site 271848011212 active site 271848011213 cytidylate kinase; Provisional; Region: cmk; PRK00023 271848011214 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 271848011215 CMP-binding site; other site 271848011216 The sites determining sugar specificity; other site 271848011217 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 271848011218 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 271848011219 RNA binding site [nucleotide binding]; other site 271848011220 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 271848011221 RNA binding site [nucleotide binding]; other site 271848011222 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 271848011223 RNA binding site [nucleotide binding]; other site 271848011224 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 271848011225 RNA binding site [nucleotide binding]; other site 271848011226 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 271848011227 RNA binding site [nucleotide binding]; other site 271848011228 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 271848011229 RNA binding site [nucleotide binding]; other site 271848011230 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271848011231 IHF dimer interface [polypeptide binding]; other site 271848011232 IHF - DNA interface [nucleotide binding]; other site 271848011233 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 271848011234 tetratricopeptide repeat protein; Provisional; Region: PRK11788 271848011235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848011236 binding surface 271848011237 TPR motif; other site 271848011238 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 271848011239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011240 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 271848011241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011242 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 271848011243 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848011244 putative ribose interaction site [chemical binding]; other site 271848011245 putative ADP binding site [chemical binding]; other site 271848011246 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 271848011247 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 271848011248 NADP binding site [chemical binding]; other site 271848011249 homopentamer interface [polypeptide binding]; other site 271848011250 substrate binding site [chemical binding]; other site 271848011251 active site 271848011252 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 271848011253 cysteine synthase B; Region: cysM; TIGR01138 271848011254 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 271848011255 dimer interface [polypeptide binding]; other site 271848011256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011257 catalytic residue [active] 271848011258 Transglycosylase SLT domain; Region: SLT_2; pfam13406 271848011259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271848011260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848011261 catalytic residue [active] 271848011262 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 271848011263 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 271848011264 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 271848011265 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848011266 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 271848011267 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 271848011268 Walker A/P-loop; other site 271848011269 ATP binding site [chemical binding]; other site 271848011270 Q-loop/lid; other site 271848011271 ABC transporter signature motif; other site 271848011272 Walker B; other site 271848011273 D-loop; other site 271848011274 H-loop/switch region; other site 271848011275 NIL domain; Region: NIL; cl09633 271848011276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848011277 dimer interface [polypeptide binding]; other site 271848011278 conserved gate region; other site 271848011279 ABC-ATPase subunit interface; other site 271848011280 NMT1-like family; Region: NMT1_2; cl15260 271848011281 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 271848011282 Ligand binding site [chemical binding]; other site 271848011283 Electron transfer flavoprotein domain; Region: ETF; pfam01012 271848011284 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 271848011285 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 271848011286 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 271848011287 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 271848011288 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 271848011289 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848011290 active site 271848011291 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 271848011292 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 271848011293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848011294 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 271848011295 Helix-turn-helix domains; Region: HTH; cl00088 271848011296 AsnC family; Region: AsnC_trans_reg; pfam01037 271848011297 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 271848011298 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 271848011299 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 271848011300 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 271848011301 RimM N-terminal domain; Region: RimM; pfam01782 271848011302 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 271848011303 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 271848011304 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 271848011305 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 271848011306 putative active site [active] 271848011307 putative CoA binding site [chemical binding]; other site 271848011308 nudix motif; other site 271848011309 metal binding site [ion binding]; metal-binding site 271848011310 CobD/Cbib protein; Region: CobD_Cbib; cl00561 271848011311 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 271848011312 GTPase RsgA; Reviewed; Region: PRK00098 271848011313 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 271848011314 RNA binding site [nucleotide binding]; other site 271848011315 homodimer interface [polypeptide binding]; other site 271848011316 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 271848011317 GTPase/Zn-binding domain interface [polypeptide binding]; other site 271848011318 GTP/Mg2+ binding site [chemical binding]; other site 271848011319 G4 box; other site 271848011320 G5 box; other site 271848011321 G1 box; other site 271848011322 Switch I region; other site 271848011323 G2 box; other site 271848011324 G3 box; other site 271848011325 Switch II region; other site 271848011326 Peptidase family M48; Region: Peptidase_M48; cl12018 271848011327 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 271848011328 catalytic site [active] 271848011329 putative active site [active] 271848011330 putative substrate binding site [chemical binding]; other site 271848011331 dimer interface [polypeptide binding]; other site 271848011332 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 271848011333 MPT binding site; other site 271848011334 trimer interface [polypeptide binding]; other site 271848011335 Protein of unknown function (DUF615); Region: DUF615; cl01147 271848011336 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 271848011337 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 271848011338 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 271848011339 folate binding site [chemical binding]; other site 271848011340 NADP+ binding site [chemical binding]; other site 271848011341 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848011342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848011343 Walker A motif; other site 271848011344 ATP binding site [chemical binding]; other site 271848011345 Walker B motif; other site 271848011346 arginine finger; other site 271848011347 Helix-turn-helix domains; Region: HTH; cl00088 271848011348 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848011349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848011350 Walker A motif; other site 271848011351 ATP binding site [chemical binding]; other site 271848011352 Walker B motif; other site 271848011353 arginine finger; other site 271848011354 Helix-turn-helix domains; Region: HTH; cl00088 271848011355 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 271848011356 dimerization interface [polypeptide binding]; other site 271848011357 active site 271848011358 FecR protein; Region: FecR; pfam04773 271848011359 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 271848011360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848011361 dimerization interface [polypeptide binding]; other site 271848011362 putative DNA binding site [nucleotide binding]; other site 271848011363 putative Zn2+ binding site [ion binding]; other site 271848011364 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 271848011365 fumarate hydratase; Reviewed; Region: fumC; PRK00485 271848011366 Class II fumarases; Region: Fumarase_classII; cd01362 271848011367 active site 271848011368 tetramer interface [polypeptide binding]; other site 271848011369 putative efflux protein, MATE family; Region: matE; TIGR00797 271848011370 MatE; Region: MatE; cl10513 271848011371 MatE; Region: MatE; cl10513 271848011372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 271848011373 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 271848011374 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 271848011375 AzlC protein; Region: AzlC; cl00570 271848011376 Cupin domain; Region: Cupin_2; cl09118 271848011377 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848011378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 271848011379 CreA protein; Region: CreA; pfam05981 271848011380 Ferredoxin [Energy production and conversion]; Region: COG1146 271848011381 4Fe-4S binding domain; Region: Fer4; cl02805 271848011382 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 271848011383 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 271848011384 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 271848011385 active site 271848011386 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 271848011387 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 271848011388 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271848011389 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 271848011390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011391 RmuC family; Region: RmuC; pfam02646 271848011392 putative acetyltransferase; Provisional; Region: PRK03624 271848011393 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848011394 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 271848011395 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 271848011396 dimer interface [polypeptide binding]; other site 271848011397 putative functional site; other site 271848011398 putative MPT binding site; other site 271848011399 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 271848011400 GTP binding site; other site 271848011401 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 271848011402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848011403 FeS/SAM binding site; other site 271848011404 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 271848011405 ribonuclease E; Reviewed; Region: rne; PRK10811 271848011406 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 271848011407 homodimer interface [polypeptide binding]; other site 271848011408 oligonucleotide binding site [chemical binding]; other site 271848011409 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 271848011410 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 271848011411 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 271848011412 active site 271848011413 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 271848011414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848011415 motif II; other site 271848011416 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848011417 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 271848011418 iron-sulfur cluster [ion binding]; other site 271848011419 [2Fe-2S] cluster binding site [ion binding]; other site 271848011420 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 271848011421 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 271848011422 tandem repeat interface [polypeptide binding]; other site 271848011423 oligomer interface [polypeptide binding]; other site 271848011424 active site residues [active] 271848011425 Predicted methyltransferases [General function prediction only]; Region: COG0313 271848011426 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 271848011427 active site 271848011428 dimer interface [polypeptide binding]; other site 271848011429 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 271848011430 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 271848011431 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 271848011432 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 271848011433 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 271848011434 dimer interface [polypeptide binding]; other site 271848011435 active site 271848011436 CoA binding pocket [chemical binding]; other site 271848011437 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848011438 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848011439 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 271848011440 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 271848011441 NAD(P) binding site [chemical binding]; other site 271848011442 homotetramer interface [polypeptide binding]; other site 271848011443 homodimer interface [polypeptide binding]; other site 271848011444 active site 271848011445 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848011446 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 271848011447 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 271848011448 dimer interface [polypeptide binding]; other site 271848011449 active site 271848011450 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 271848011451 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848011452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848011453 DNA binding residues [nucleotide binding] 271848011454 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 271848011455 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 271848011456 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 271848011457 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271848011458 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271848011459 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848011460 protein binding site [polypeptide binding]; other site 271848011461 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848011462 protein binding site [polypeptide binding]; other site 271848011463 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271848011464 GTP-binding protein LepA; Provisional; Region: PRK05433 271848011465 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 271848011466 G1 box; other site 271848011467 putative GEF interaction site [polypeptide binding]; other site 271848011468 GTP/Mg2+ binding site [chemical binding]; other site 271848011469 Switch I region; other site 271848011470 G2 box; other site 271848011471 G3 box; other site 271848011472 Switch II region; other site 271848011473 G4 box; other site 271848011474 G5 box; other site 271848011475 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 271848011476 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 271848011477 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 271848011478 signal peptidase I; Provisional; Region: PRK10861 271848011479 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 271848011480 Catalytic site [active] 271848011481 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 271848011482 ribonuclease III; Provisional; Region: PRK14718 271848011483 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 271848011484 dimerization interface [polypeptide binding]; other site 271848011485 active site 271848011486 metal binding site [ion binding]; metal-binding site 271848011487 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 271848011488 GTPase Era; Reviewed; Region: era; PRK00089 271848011489 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 271848011490 G1 box; other site 271848011491 GTP/Mg2+ binding site [chemical binding]; other site 271848011492 Switch I region; other site 271848011493 G2 box; other site 271848011494 Switch II region; other site 271848011495 G3 box; other site 271848011496 G4 box; other site 271848011497 G5 box; other site 271848011498 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 271848011499 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 271848011500 Recombination protein O N terminal; Region: RecO_N; cl15812 271848011501 Recombination protein O C terminal; Region: RecO_C; pfam02565 271848011502 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 271848011503 active site 271848011504 hydrophilic channel; other site 271848011505 dimerization interface [polypeptide binding]; other site 271848011506 catalytic residues [active] 271848011507 active site lid [active] 271848011508 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 271848011509 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 271848011510 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848011511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848011512 active site 271848011513 phosphorylation site [posttranslational modification] 271848011514 intermolecular recognition site; other site 271848011515 dimerization interface [polypeptide binding]; other site 271848011516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848011517 Walker A motif; other site 271848011518 ATP binding site [chemical binding]; other site 271848011519 Walker B motif; other site 271848011520 Helix-turn-helix domains; Region: HTH; cl00088 271848011521 elongation factor P; Validated; Region: PRK00529 271848011522 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 271848011523 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 271848011524 RNA binding site [nucleotide binding]; other site 271848011525 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 271848011526 RNA binding site [nucleotide binding]; other site 271848011527 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 271848011528 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 271848011529 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 271848011530 GIY-YIG motif/motif A; other site 271848011531 active site 271848011532 catalytic site [active] 271848011533 putative DNA binding site [nucleotide binding]; other site 271848011534 metal binding site [ion binding]; metal-binding site 271848011535 UvrB/uvrC motif; Region: UVR; pfam02151 271848011536 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 271848011537 ERCC4-type nuclease [DNA replication, recombination, and repair]; Region: MUS81; COG1948 271848011538 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 271848011539 MULE transposase domain; Region: MULE; pfam10551 271848011540 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848011541 GAF domain; Region: GAF; cl15785 271848011542 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848011543 Helix-turn-helix domains; Region: HTH; cl00088 271848011544 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 271848011545 putative effector binding pocket; other site 271848011546 putative dimerization interface [polypeptide binding]; other site 271848011547 Pirin-related protein [General function prediction only]; Region: COG1741 271848011548 Cupin domain; Region: Cupin_2; cl09118 271848011549 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 271848011550 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848011551 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 271848011552 Protein of unknown function (DUF461); Region: DUF461; cl01071 271848011553 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271848011554 Cu(I) binding site [ion binding]; other site 271848011555 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848011556 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 271848011557 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 271848011558 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 271848011559 active site 271848011560 homotetramer interface [polypeptide binding]; other site 271848011561 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848011562 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848011563 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848011564 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848011565 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 271848011566 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271848011567 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 271848011568 Walker A/P-loop; other site 271848011569 ATP binding site [chemical binding]; other site 271848011570 Q-loop/lid; other site 271848011571 ABC transporter signature motif; other site 271848011572 Walker B; other site 271848011573 D-loop; other site 271848011574 H-loop/switch region; other site 271848011575 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 271848011576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848011577 putative ADP-binding pocket [chemical binding]; other site 271848011578 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 271848011579 FAD dependent oxidoreductase; Region: DAO; pfam01266 271848011580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011582 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848011583 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848011584 dimerization interface [polypeptide binding]; other site 271848011585 ligand binding site [chemical binding]; other site 271848011586 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 271848011587 Phosphoesterase family; Region: Phosphoesterase; cl15450 271848011588 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848011589 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848011590 pyridoxamine kinase; Validated; Region: PRK05756 271848011591 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 271848011592 dimer interface [polypeptide binding]; other site 271848011593 pyridoxal binding site [chemical binding]; other site 271848011594 ATP binding site [chemical binding]; other site 271848011595 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848011596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848011597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848011598 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 271848011599 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 271848011600 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 271848011601 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 271848011602 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 271848011603 ligand binding site; other site 271848011604 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 271848011605 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 271848011606 B12 binding site [chemical binding]; other site 271848011607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848011608 FeS/SAM binding site; other site 271848011609 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 271848011610 putative active site [active] 271848011611 YdjC motif; other site 271848011612 Mg binding site [ion binding]; other site 271848011613 putative homodimer interface [polypeptide binding]; other site 271848011614 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 271848011615 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 271848011616 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848011617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848011618 dimer interface [polypeptide binding]; other site 271848011619 conserved gate region; other site 271848011620 putative PBP binding loops; other site 271848011621 ABC-ATPase subunit interface; other site 271848011622 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848011623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848011624 dimer interface [polypeptide binding]; other site 271848011625 conserved gate region; other site 271848011626 putative PBP binding loops; other site 271848011627 ABC-ATPase subunit interface; other site 271848011628 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 271848011629 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 271848011630 Walker A/P-loop; other site 271848011631 ATP binding site [chemical binding]; other site 271848011632 Q-loop/lid; other site 271848011633 ABC transporter signature motif; other site 271848011634 Walker B; other site 271848011635 D-loop; other site 271848011636 H-loop/switch region; other site 271848011637 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848011638 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848011639 conserved cys residue [active] 271848011640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848011641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848011642 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 271848011643 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848011644 inhibitor-cofactor binding pocket; inhibition site 271848011645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011646 catalytic residue [active] 271848011647 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 271848011648 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 271848011649 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848011650 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 271848011651 NAD(P) binding site [chemical binding]; other site 271848011652 catalytic residues [active] 271848011653 Succinylarginine dihydrolase; Region: AstB; cl01511 271848011654 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 271848011655 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 271848011656 active site 271848011657 Zn binding site [ion binding]; other site 271848011658 glutathionine S-transferase; Provisional; Region: PRK10542 271848011659 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 271848011660 C-terminal domain interface [polypeptide binding]; other site 271848011661 GSH binding site (G-site) [chemical binding]; other site 271848011662 dimer interface [polypeptide binding]; other site 271848011663 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 271848011664 dimer interface [polypeptide binding]; other site 271848011665 N-terminal domain interface [polypeptide binding]; other site 271848011666 substrate binding pocket (H-site) [chemical binding]; other site 271848011667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848011668 Helix-turn-helix domains; Region: HTH; cl00088 271848011669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848011670 dimerization interface [polypeptide binding]; other site 271848011671 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 271848011672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848011673 substrate binding pocket [chemical binding]; other site 271848011674 membrane-bound complex binding site; other site 271848011675 hinge residues; other site 271848011676 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 271848011677 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848011678 putative di-iron ligands [ion binding]; other site 271848011679 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 271848011680 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 271848011681 Subunit I/III interface [polypeptide binding]; other site 271848011682 Subunit III/IV interface [polypeptide binding]; other site 271848011683 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 271848011684 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 271848011685 D-pathway; other site 271848011686 Putative ubiquinol binding site [chemical binding]; other site 271848011687 Low-spin heme (heme b) binding site [chemical binding]; other site 271848011688 Putative water exit pathway; other site 271848011689 Binuclear center (heme o3/CuB) [ion binding]; other site 271848011690 K-pathway; other site 271848011691 Putative proton exit pathway; other site 271848011692 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 271848011693 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848011694 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 271848011695 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 271848011696 Predicted transcriptional regulator [Transcription]; Region: COG1959 271848011697 Helix-turn-helix domains; Region: HTH; cl00088 271848011698 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 271848011699 Domain of unknown function DUF59; Region: DUF59; cl00941 271848011700 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 271848011701 trimerization site [polypeptide binding]; other site 271848011702 active site 271848011703 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 271848011704 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 271848011705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848011706 catalytic residue [active] 271848011707 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 271848011708 FeS assembly ATPase SufC; Region: sufC; TIGR01978 271848011709 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 271848011710 Walker A/P-loop; other site 271848011711 ATP binding site [chemical binding]; other site 271848011712 Q-loop/lid; other site 271848011713 ABC transporter signature motif; other site 271848011714 Walker B; other site 271848011715 D-loop; other site 271848011716 H-loop/switch region; other site 271848011717 putative ABC transporter; Region: ycf24; CHL00085 271848011718 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 271848011719 NnrS protein; Region: NnrS; cl01258 271848011720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848011721 dimerization interface [polypeptide binding]; other site 271848011722 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848011723 dimer interface [polypeptide binding]; other site 271848011724 putative CheW interface [polypeptide binding]; other site 271848011725 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 271848011726 HemN C-terminal domain; Region: HemN_C; pfam06969 271848011727 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848011728 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848011729 ligand binding site [chemical binding]; other site 271848011730 flexible hinge region; other site 271848011731 Helix-turn-helix domains; Region: HTH; cl00088 271848011732 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 271848011733 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 271848011734 FMN binding site [chemical binding]; other site 271848011735 substrate binding site [chemical binding]; other site 271848011736 putative catalytic residue [active] 271848011737 Peptidase family U32; Region: Peptidase_U32; cl03113 271848011738 Peptidase family U32; Region: Peptidase_U32; cl03113 271848011739 SCP-2 sterol transfer family; Region: SCP2; cl01225 271848011740 DGC domain; Region: DGC; cl01742 271848011741 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 271848011742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848011743 FeS/SAM binding site; other site 271848011744 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 271848011745 Class III ribonucleotide reductase; Region: RNR_III; cd01675 271848011746 effector binding site; other site 271848011747 active site 271848011748 Zn binding site [ion binding]; other site 271848011749 NnrS protein; Region: NnrS; cl01258 271848011750 Domain of unknown function DUF59; Region: DUF59; cl00941 271848011751 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 271848011752 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 271848011753 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 271848011754 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848011755 Di-iron ligands [ion binding]; other site 271848011756 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 271848011757 DNA photolyase; Region: DNA_photolyase; pfam00875 271848011758 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 271848011759 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 271848011760 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 271848011761 ligand-binding site [chemical binding]; other site 271848011762 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848011763 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848011764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848011765 DNA binding residues [nucleotide binding] 271848011766 dimerization interface [polypeptide binding]; other site 271848011767 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 271848011768 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271848011769 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 271848011770 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 271848011771 active sites [active] 271848011772 tetramer interface [polypeptide binding]; other site 271848011773 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 271848011774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848011775 DNA-binding site [nucleotide binding]; DNA binding site 271848011776 UTRA domain; Region: UTRA; cl01230 271848011777 urocanate hydratase; Provisional; Region: PRK05414 271848011778 HutD; Region: HutD; cl01532 271848011779 imidazolonepropionase; Validated; Region: PRK09356 271848011780 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 271848011781 active site 271848011782 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 271848011783 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 271848011784 active site 271848011785 N-formylglutamate amidohydrolase; Region: FGase; cl01522 271848011786 Peptidase C26; Region: Peptidase_C26; pfam07722 271848011787 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 271848011788 catalytic triad [active] 271848011789 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 271848011790 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 271848011791 putative aminotransferase; Validated; Region: PRK07480 271848011792 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848011793 inhibitor-cofactor binding pocket; inhibition site 271848011794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011795 catalytic residue [active] 271848011796 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848011797 Helix-turn-helix domains; Region: HTH; cl00088 271848011798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848011799 dimerization interface [polypeptide binding]; other site 271848011800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848011801 active site 271848011802 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848011803 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848011804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011805 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848011806 putative substrate translocation pore; other site 271848011807 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 271848011808 N-acetylglutamate synthase; Validated; Region: PRK05279 271848011809 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 271848011810 putative feedback inhibition sensing region; other site 271848011811 putative nucleotide binding site [chemical binding]; other site 271848011812 putative substrate binding site [chemical binding]; other site 271848011813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848011814 Coenzyme A binding pocket [chemical binding]; other site 271848011815 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 271848011816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848011817 ATP binding site [chemical binding]; other site 271848011818 putative Mg++ binding site [ion binding]; other site 271848011819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848011820 nucleotide binding region [chemical binding]; other site 271848011821 ATP-binding site [chemical binding]; other site 271848011822 Helicase associated domain (HA2); Region: HA2; cl04503 271848011823 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 271848011824 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 271848011825 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 271848011826 Uncharacterized conserved protein [Function unknown]; Region: COG3391 271848011827 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 271848011828 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 271848011829 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 271848011830 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 271848011831 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 271848011832 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 271848011833 putative MPT binding site; other site 271848011834 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 271848011835 active site residue [active] 271848011836 glutamine synthetase; Provisional; Region: glnA; PRK09469 271848011837 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 271848011838 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 271848011839 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 271848011840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848011841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848011842 dimer interface [polypeptide binding]; other site 271848011843 phosphorylation site [posttranslational modification] 271848011844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848011845 ATP binding site [chemical binding]; other site 271848011846 Mg2+ binding site [ion binding]; other site 271848011847 G-X-G motif; other site 271848011848 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 271848011849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848011850 active site 271848011851 phosphorylation site [posttranslational modification] 271848011852 intermolecular recognition site; other site 271848011853 dimerization interface [polypeptide binding]; other site 271848011854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848011855 Walker A motif; other site 271848011856 ATP binding site [chemical binding]; other site 271848011857 Walker B motif; other site 271848011858 arginine finger; other site 271848011859 Helix-turn-helix domains; Region: HTH; cl00088 271848011860 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 271848011861 putative catalytic site [active] 271848011862 putative phosphate binding site [ion binding]; other site 271848011863 active site 271848011864 metal binding site A [ion binding]; metal-binding site 271848011865 DNA binding site [nucleotide binding] 271848011866 putative AP binding site [nucleotide binding]; other site 271848011867 putative metal binding site B [ion binding]; other site 271848011868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848011869 transcriptional regulator NarL; Provisional; Region: PRK10651 271848011870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848011871 active site 271848011872 phosphorylation site [posttranslational modification] 271848011873 intermolecular recognition site; other site 271848011874 dimerization interface [polypeptide binding]; other site 271848011875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848011876 DNA binding residues [nucleotide binding] 271848011877 dimerization interface [polypeptide binding]; other site 271848011878 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 271848011879 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 271848011880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848011881 dimerization interface [polypeptide binding]; other site 271848011882 GAF domain; Region: GAF; cl15785 271848011883 Histidine kinase; Region: HisKA_3; pfam07730 271848011884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 271848011885 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 271848011886 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 271848011887 nitrate reductase, beta subunit; Region: narH; TIGR01660 271848011888 4Fe-4S binding domain; Region: Fer4; cl02805 271848011889 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 271848011890 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 271848011891 [4Fe-4S] binding site [ion binding]; other site 271848011892 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848011893 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848011894 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848011895 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 271848011896 molybdopterin cofactor binding site; other site 271848011897 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 271848011898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011899 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 271848011900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011901 putative substrate translocation pore; other site 271848011902 OpgC protein; Region: OpgC_C; cl00792 271848011903 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271848011904 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 271848011905 active site 271848011906 catalytic triad [active] 271848011907 oxyanion hole [active] 271848011908 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 271848011909 active site 271848011910 DNA polymerase IV; Validated; Region: PRK02406 271848011911 DNA binding site [nucleotide binding] 271848011912 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 271848011913 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 271848011914 active site 271848011915 Zn binding site [ion binding]; other site 271848011916 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 271848011917 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 271848011918 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 271848011919 homodimer interface [polypeptide binding]; other site 271848011920 NADP binding site [chemical binding]; other site 271848011921 substrate binding site [chemical binding]; other site 271848011922 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 271848011923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848011924 active site 271848011925 phosphorylation site [posttranslational modification] 271848011926 intermolecular recognition site; other site 271848011927 dimerization interface [polypeptide binding]; other site 271848011928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848011929 DNA binding residues [nucleotide binding] 271848011930 dimerization interface [polypeptide binding]; other site 271848011931 CHASE domain; Region: CHASE; cl01369 271848011932 PAS domain S-box; Region: sensory_box; TIGR00229 271848011933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848011934 putative active site [active] 271848011935 heme pocket [chemical binding]; other site 271848011936 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 271848011937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848011938 dimer interface [polypeptide binding]; other site 271848011939 phosphorylation site [posttranslational modification] 271848011940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848011941 ATP binding site [chemical binding]; other site 271848011942 Mg2+ binding site [ion binding]; other site 271848011943 G-X-G motif; other site 271848011944 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 271848011945 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 271848011946 dimer interface [polypeptide binding]; other site 271848011947 TPP-binding site [chemical binding]; other site 271848011948 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 271848011949 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 271848011950 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848011951 E3 interaction surface; other site 271848011952 lipoyl attachment site [posttranslational modification]; other site 271848011953 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848011954 E3 interaction surface; other site 271848011955 lipoyl attachment site [posttranslational modification]; other site 271848011956 e3 binding domain; Region: E3_binding; pfam02817 271848011957 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 271848011958 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848011959 E3 interaction surface; other site 271848011960 lipoyl attachment site [posttranslational modification]; other site 271848011961 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 271848011962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848011964 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271848011965 Phasin protein; Region: Phasin_2; cl11491 271848011966 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 271848011967 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848011968 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848011969 Helix-turn-helix domains; Region: HTH; cl00088 271848011970 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848011971 Cysteine-rich domain; Region: CCG; pfam02754 271848011972 Cysteine-rich domain; Region: CCG; pfam02754 271848011973 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 271848011974 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 271848011975 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271848011976 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271848011977 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 271848011978 active site 271848011979 Helix-turn-helix domains; Region: HTH; cl00088 271848011980 Rrf2 family protein; Region: rrf2_super; TIGR00738 271848011981 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848011982 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 271848011983 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848011984 catalytic residue [active] 271848011985 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 271848011986 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 271848011987 trimerization site [polypeptide binding]; other site 271848011988 active site 271848011989 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 271848011990 co-chaperone HscB; Provisional; Region: hscB; PRK03578 271848011991 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271848011992 HSP70 interaction site [polypeptide binding]; other site 271848011993 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 271848011994 chaperone protein HscA; Provisional; Region: hscA; PRK05183 271848011995 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 271848011996 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848011997 catalytic loop [active] 271848011998 iron binding site [ion binding]; other site 271848011999 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 271848012000 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 271848012001 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 271848012002 dimer interface [polypeptide binding]; other site 271848012003 putative anticodon binding site; other site 271848012004 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 271848012005 motif 1; other site 271848012006 active site 271848012007 motif 2; other site 271848012008 motif 3; other site 271848012009 peptide chain release factor 2; Validated; Region: prfB; PRK00578 271848012010 RF-1 domain; Region: RF-1; cl02875 271848012011 RF-1 domain; Region: RF-1; cl02875 271848012012 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 271848012013 DHH family; Region: DHH; pfam01368 271848012014 DHHA1 domain; Region: DHHA1; pfam02272 271848012015 Sulfatase; Region: Sulfatase; cl10460 271848012016 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 271848012017 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271848012018 FtsX-like permease family; Region: FtsX; cl15850 271848012019 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 271848012020 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271848012021 Walker A/P-loop; other site 271848012022 ATP binding site [chemical binding]; other site 271848012023 Q-loop/lid; other site 271848012024 ABC transporter signature motif; other site 271848012025 Walker B; other site 271848012026 D-loop; other site 271848012027 H-loop/switch region; other site 271848012028 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 271848012029 active site 271848012030 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 271848012031 Competence protein; Region: Competence; cl00471 271848012032 Competence protein; Region: Competence; cl00471 271848012033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848012034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848012035 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741 271848012036 nucleophilic elbow; other site 271848012037 catalytic triad; other site 271848012038 CTP synthetase; Validated; Region: pyrG; PRK05380 271848012039 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 271848012040 Catalytic site [active] 271848012041 active site 271848012042 UTP binding site [chemical binding]; other site 271848012043 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 271848012044 active site 271848012045 putative oxyanion hole; other site 271848012046 catalytic triad [active] 271848012047 NeuB family; Region: NeuB; cl00496 271848012048 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271848012049 enolase; Provisional; Region: eno; PRK00077 271848012050 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 271848012051 dimer interface [polypeptide binding]; other site 271848012052 metal binding site [ion binding]; metal-binding site 271848012053 substrate binding pocket [chemical binding]; other site 271848012054 Septum formation initiator; Region: DivIC; cl11433 271848012055 Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281 271848012056 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 271848012057 dimerization interface [polypeptide binding]; other site 271848012058 domain crossover interface; other site 271848012059 redox-dependent activation switch; other site 271848012060 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 271848012061 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 271848012062 trimer interface [polypeptide binding]; other site 271848012063 putative metal binding site [ion binding]; other site 271848012064 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 271848012065 dinuclear metal binding motif [ion binding]; other site 271848012066 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 271848012067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848012068 nucleophilic elbow; other site 271848012069 catalytic triad; other site 271848012070 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 271848012071 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 271848012072 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 271848012073 active site 271848012074 putative substrate binding region [chemical binding]; other site 271848012075 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 271848012076 active site 271848012077 HIGH motif; other site 271848012078 dimer interface [polypeptide binding]; other site 271848012079 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848012080 active site 271848012081 KMSKS motif; other site 271848012082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848012083 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 271848012084 dihydrodipicolinate synthase; Region: dapA; TIGR00674 271848012085 dimer interface [polypeptide binding]; other site 271848012086 active site 271848012087 catalytic residue [active] 271848012088 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 271848012089 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848012090 Uncharacterized conserved protein [Function unknown]; Region: COG2850 271848012091 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 271848012092 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 271848012093 MutS domain I; Region: MutS_I; pfam01624 271848012094 MutS domain II; Region: MutS_II; pfam05188 271848012095 MutS family domain IV; Region: MutS_IV; pfam05190 271848012096 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 271848012097 Walker A/P-loop; other site 271848012098 ATP binding site [chemical binding]; other site 271848012099 Q-loop/lid; other site 271848012100 ABC transporter signature motif; other site 271848012101 Walker B; other site 271848012102 D-loop; other site 271848012103 H-loop/switch region; other site 271848012104 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848012105 active site 271848012106 DNA binding site [nucleotide binding] 271848012107 Int/Topo IB signature motif; other site 271848012108 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 271848012109 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848012110 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 271848012111 catalytic residue [active] 271848012112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848012113 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848012114 PAAR motif; Region: PAAR_motif; cl15808 271848012115 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 271848012116 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848012117 HTH-like domain; Region: HTH_21; pfam13276 271848012118 Integrase core domain; Region: rve; cl01316 271848012119 Integrase core domain; Region: rve_3; cl15866 271848012120 Helix-turn-helix domains; Region: HTH; cl00088 271848012121 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 271848012122 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 271848012123 active site 271848012124 dimerization interface [polypeptide binding]; other site 271848012125 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 271848012126 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 271848012127 serine O-acetyltransferase; Region: cysE; TIGR01172 271848012128 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 271848012129 trimer interface [polypeptide binding]; other site 271848012130 active site 271848012131 substrate binding site [chemical binding]; other site 271848012132 CoA binding site [chemical binding]; other site 271848012133 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848012134 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 271848012135 putative active site [active] 271848012136 putative metal binding site [ion binding]; other site 271848012137 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 271848012138 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 271848012139 substrate binding site [chemical binding]; other site 271848012140 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 271848012141 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 271848012142 substrate binding site [chemical binding]; other site 271848012143 TPR repeat; Region: TPR_11; pfam13414 271848012144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848012145 binding surface 271848012146 TPR motif; other site 271848012147 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 271848012148 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 271848012149 active site 271848012150 HIGH motif; other site 271848012151 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 271848012152 KMSKS motif; other site 271848012153 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 271848012154 tRNA binding surface [nucleotide binding]; other site 271848012155 anticodon binding site; other site 271848012156 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271848012157 endonuclease III; Region: ENDO3c; smart00478 271848012158 minor groove reading motif; other site 271848012159 helix-hairpin-helix signature motif; other site 271848012160 substrate binding pocket [chemical binding]; other site 271848012161 active site 271848012162 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848012163 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 271848012164 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 271848012165 Ligand Binding Site [chemical binding]; other site 271848012166 TilS substrate binding domain; Region: TilS; pfam09179 271848012167 B3/4 domain; Region: B3_4; cl11458 271848012168 aspartate kinase; Reviewed; Region: PRK06635 271848012169 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 271848012170 putative nucleotide binding site [chemical binding]; other site 271848012171 putative catalytic residues [active] 271848012172 putative Mg ion binding site [ion binding]; other site 271848012173 putative aspartate binding site [chemical binding]; other site 271848012174 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 271848012175 putative allosteric regulatory site; other site 271848012176 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 271848012177 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 271848012178 active site 271848012179 catalytic triad [active] 271848012180 oxyanion hole [active] 271848012181 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 271848012182 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 271848012183 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 271848012184 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848012185 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848012186 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 271848012187 ligand-binding site [chemical binding]; other site 271848012188 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848012189 AMP-binding enzyme; Region: AMP-binding; cl15778 271848012190 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848012191 Transmembrane secretion effector; Region: MFS_3; pfam05977 271848012192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848012193 putative substrate translocation pore; other site 271848012194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 271848012195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848012196 peptide synthase; Provisional; Region: PRK12316 271848012197 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848012198 AMP-binding enzyme; Region: AMP-binding; cl15778 271848012199 AMP-binding enzyme; Region: AMP-binding; cl15778 271848012200 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848012201 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 271848012202 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848012203 AMP-binding enzyme; Region: AMP-binding; cl15778 271848012204 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848012205 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848012206 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 271848012207 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 271848012208 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848012209 active site 271848012210 iron coordination sites [ion binding]; other site 271848012211 substrate binding pocket [chemical binding]; other site 271848012212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848012213 S-adenosylmethionine binding site [chemical binding]; other site 271848012214 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848012215 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 271848012216 TPP-binding site [chemical binding]; other site 271848012217 dimer interface [polypeptide binding]; other site 271848012218 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 271848012219 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271848012220 PYR/PP interface [polypeptide binding]; other site 271848012221 dimer interface [polypeptide binding]; other site 271848012222 TPP binding site [chemical binding]; other site 271848012223 OpgC protein; Region: OpgC_C; cl00792 271848012224 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271848012225 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848012226 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 271848012227 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848012228 catalytic residue [active] 271848012229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848012230 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848012231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848012232 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 271848012233 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848012234 Active Sites [active] 271848012235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848012236 G1 box; other site 271848012237 GTP/Mg2+ binding site [chemical binding]; other site 271848012238 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 271848012239 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 271848012240 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 271848012241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012242 catalytic residue [active] 271848012243 dimer interface [polypeptide binding]; other site 271848012244 argininosuccinate lyase; Provisional; Region: PRK02186 271848012245 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848012246 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 271848012247 tetramer interface [polypeptide binding]; other site 271848012248 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 271848012249 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 271848012250 active site 271848012251 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 271848012252 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 271848012253 putative [Fe4-S4] binding site [ion binding]; other site 271848012254 putative molybdopterin cofactor binding site [chemical binding]; other site 271848012255 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848012256 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 271848012257 putative molybdopterin cofactor binding site; other site 271848012258 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 271848012259 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 271848012260 NAD binding site [chemical binding]; other site 271848012261 homotetramer interface [polypeptide binding]; other site 271848012262 homodimer interface [polypeptide binding]; other site 271848012263 substrate binding site [chemical binding]; other site 271848012264 active site 271848012265 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 271848012266 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 271848012267 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 271848012268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848012269 dimer interface [polypeptide binding]; other site 271848012270 conserved gate region; other site 271848012271 putative PBP binding loops; other site 271848012272 ABC-ATPase subunit interface; other site 271848012273 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 271848012274 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 271848012275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848012276 dimer interface [polypeptide binding]; other site 271848012277 conserved gate region; other site 271848012278 putative PBP binding loops; other site 271848012279 ABC-ATPase subunit interface; other site 271848012280 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 271848012281 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848012282 Walker A/P-loop; other site 271848012283 ATP binding site [chemical binding]; other site 271848012284 Q-loop/lid; other site 271848012285 ABC transporter signature motif; other site 271848012286 Walker B; other site 271848012287 D-loop; other site 271848012288 H-loop/switch region; other site 271848012289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848012290 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 271848012291 Walker A/P-loop; other site 271848012292 ATP binding site [chemical binding]; other site 271848012293 Q-loop/lid; other site 271848012294 ABC transporter signature motif; other site 271848012295 Walker B; other site 271848012296 D-loop; other site 271848012297 H-loop/switch region; other site 271848012298 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848012299 NlpC/P60 family; Region: NLPC_P60; cl11438 271848012300 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 271848012301 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 271848012302 active site 271848012303 nucleophile elbow; other site 271848012304 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 271848012305 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 271848012306 active site 271848012307 HIGH motif; other site 271848012308 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 271848012309 active site 271848012310 KMSKS motif; other site 271848012311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848012312 Coenzyme A binding pocket [chemical binding]; other site 271848012313 Cupin domain; Region: Cupin_2; cl09118 271848012314 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848012315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848012316 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 271848012317 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 271848012318 putative active site pocket [active] 271848012319 dimerization interface [polypeptide binding]; other site 271848012320 putative catalytic residue [active] 271848012321 malate synthase A; Region: malate_syn_A; TIGR01344 271848012322 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 271848012323 active site 271848012324 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 271848012325 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848012326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848012327 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848012328 putative effector binding pocket; other site 271848012329 dimerization interface [polypeptide binding]; other site 271848012330 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848012331 Ligand Binding Site [chemical binding]; other site 271848012332 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 271848012333 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 271848012334 tetramer interface [polypeptide binding]; other site 271848012335 active site 271848012336 Mg2+/Mn2+ binding site [ion binding]; other site 271848012337 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271848012338 DEAD-like helicases superfamily; Region: DEXDc; smart00487 271848012339 ATP binding site [chemical binding]; other site 271848012340 Mg++ binding site [ion binding]; other site 271848012341 motif III; other site 271848012342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848012343 nucleotide binding region [chemical binding]; other site 271848012344 ATP-binding site [chemical binding]; other site 271848012345 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 271848012346 acyl-CoA binding pocket [chemical binding]; other site 271848012347 CoA binding site [chemical binding]; other site 271848012348 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 271848012349 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 271848012350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848012351 Coenzyme A binding pocket [chemical binding]; other site 271848012352 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 271848012353 Fe-S cluster binding site [ion binding]; other site 271848012354 active site 271848012355 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 271848012356 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 271848012357 dimer interface [polypeptide binding]; other site 271848012358 substrate binding site [chemical binding]; other site 271848012359 ATP binding site [chemical binding]; other site 271848012360 lysophospholipid transporter LplT; Provisional; Region: PRK11195 271848012361 alanine racemase; Reviewed; Region: dadX; PRK03646 271848012362 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 271848012363 active site 271848012364 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848012365 substrate binding site [chemical binding]; other site 271848012366 catalytic residues [active] 271848012367 dimer interface [polypeptide binding]; other site 271848012368 DNA repair protein RadA; Provisional; Region: PRK11823 271848012369 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 271848012370 Walker A motif/ATP binding site; other site 271848012371 ATP binding site [chemical binding]; other site 271848012372 Walker B motif; other site 271848012373 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271848012374 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 271848012375 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 271848012376 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271848012377 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271848012378 ABC transporter; Region: ABC_tran_2; pfam12848 271848012379 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271848012380 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 271848012381 catalytic residues [active] 271848012382 dimer interface [polypeptide binding]; other site 271848012383 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 271848012384 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 271848012385 putative active site [active] 271848012386 catalytic site [active] 271848012387 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 271848012388 putative active site [active] 271848012389 catalytic site [active] 271848012390 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 271848012391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848012392 S-adenosylmethionine binding site [chemical binding]; other site 271848012393 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 271848012394 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 271848012395 metal binding site [ion binding]; metal-binding site 271848012396 dimer interface [polypeptide binding]; other site 271848012397 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 271848012398 ArsC family; Region: ArsC; pfam03960 271848012399 putative catalytic residues [active] 271848012400 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 271848012401 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 271848012402 trimer interface [polypeptide binding]; other site 271848012403 active site 271848012404 substrate binding site [chemical binding]; other site 271848012405 CoA binding site [chemical binding]; other site 271848012406 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 271848012407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848012408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012409 homodimer interface [polypeptide binding]; other site 271848012410 catalytic residue [active] 271848012411 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 271848012412 EamA-like transporter family; Region: EamA; cl01037 271848012413 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271848012414 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 271848012415 Walker A/P-loop; other site 271848012416 ATP binding site [chemical binding]; other site 271848012417 Q-loop/lid; other site 271848012418 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 271848012419 Q-loop/lid; other site 271848012420 ABC transporter signature motif; other site 271848012421 Walker B; other site 271848012422 D-loop; other site 271848012423 H-loop/switch region; other site 271848012424 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 271848012425 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 271848012426 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 271848012427 nucleotide binding pocket [chemical binding]; other site 271848012428 K-X-D-G motif; other site 271848012429 catalytic site [active] 271848012430 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 271848012431 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 271848012432 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 271848012433 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 271848012434 Dimer interface [polypeptide binding]; other site 271848012435 BRCT sequence motif; other site 271848012436 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 271848012437 active site 271848012438 catalytic residues [active] 271848012439 metal binding site [ion binding]; metal-binding site 271848012440 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 271848012441 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848012442 RNA binding surface [nucleotide binding]; other site 271848012443 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 271848012444 active site 271848012445 PII uridylyl-transferase; Provisional; Region: PRK03059 271848012446 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271848012447 metal binding triad; other site 271848012448 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271848012449 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271848012450 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 271848012451 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 271848012452 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 271848012453 active site 271848012454 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 271848012455 rRNA interaction site [nucleotide binding]; other site 271848012456 S8 interaction site; other site 271848012457 putative laminin-1 binding site; other site 271848012458 elongation factor Ts; Provisional; Region: tsf; PRK09377 271848012459 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 271848012460 Elongation factor TS; Region: EF_TS; pfam00889 271848012461 Elongation factor TS; Region: EF_TS; pfam00889 271848012462 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 271848012463 putative nucleotide binding site [chemical binding]; other site 271848012464 uridine monophosphate binding site [chemical binding]; other site 271848012465 homohexameric interface [polypeptide binding]; other site 271848012466 ribosome recycling factor; Reviewed; Region: frr; PRK00083 271848012467 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 271848012468 hinge region; other site 271848012469 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 271848012470 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 271848012471 catalytic residue [active] 271848012472 putative FPP diphosphate binding site; other site 271848012473 putative FPP binding hydrophobic cleft; other site 271848012474 dimer interface [polypeptide binding]; other site 271848012475 putative IPP diphosphate binding site; other site 271848012476 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 271848012477 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 271848012478 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 271848012479 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 271848012480 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 271848012481 zinc metallopeptidase RseP; Provisional; Region: PRK10779 271848012482 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 271848012483 active site 271848012484 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 271848012485 protein binding site [polypeptide binding]; other site 271848012486 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 271848012487 putative substrate binding region [chemical binding]; other site 271848012488 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 271848012489 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271848012490 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271848012491 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271848012492 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271848012493 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271848012494 Surface antigen; Region: Bac_surface_Ag; cl03097 271848012495 periplasmic chaperone; Provisional; Region: PRK10780 271848012496 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 271848012497 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 271848012498 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 271848012499 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 271848012500 trimer interface [polypeptide binding]; other site 271848012501 active site 271848012502 UDP-GlcNAc binding site [chemical binding]; other site 271848012503 lipid binding site [chemical binding]; lipid-binding site 271848012504 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 271848012505 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 271848012506 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 271848012507 active site 271848012508 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 271848012509 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 271848012510 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 271848012511 RNA/DNA hybrid binding site [nucleotide binding]; other site 271848012512 active site 271848012513 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 271848012514 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 271848012515 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 271848012516 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848012517 peptidase domain interface [polypeptide binding]; other site 271848012518 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848012519 active site 271848012520 catalytic triad [active] 271848012521 calcium binding site [ion binding]; other site 271848012522 Phytochelatin synthase; Region: Phytochelatin; pfam05023 271848012523 phosphoenolpyruvate synthase; Validated; Region: PRK06464 271848012524 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 271848012525 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 271848012526 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 271848012527 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 271848012528 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 271848012529 SmpB-tmRNA interface; other site 271848012530 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 271848012531 putative coenzyme Q binding site [chemical binding]; other site 271848012532 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 271848012533 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 271848012534 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 271848012535 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271848012536 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 271848012537 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271848012538 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 271848012539 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 271848012540 active site 271848012541 GMP synthase; Reviewed; Region: guaA; PRK00074 271848012542 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 271848012543 AMP/PPi binding site [chemical binding]; other site 271848012544 candidate oxyanion hole; other site 271848012545 catalytic triad [active] 271848012546 potential glutamine specificity residues [chemical binding]; other site 271848012547 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 271848012548 ATP Binding subdomain [chemical binding]; other site 271848012549 Ligand Binding sites [chemical binding]; other site 271848012550 Dimerization subdomain; other site 271848012551 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 271848012552 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 271848012553 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 271848012554 nucleoside/Zn binding site; other site 271848012555 dimer interface [polypeptide binding]; other site 271848012556 catalytic motif [active] 271848012557 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 271848012558 dimer interface [polypeptide binding]; other site 271848012559 catalytic triad [active] 271848012560 Transcriptional regulators [Transcription]; Region: GntR; COG1802 271848012561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848012562 DNA-binding site [nucleotide binding]; DNA binding site 271848012563 FCD domain; Region: FCD; cl11656 271848012564 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 271848012565 Na binding site [ion binding]; other site 271848012566 putative substrate binding site [chemical binding]; other site 271848012567 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 271848012568 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 271848012569 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 271848012570 active site 271848012571 catalytic site [active] 271848012572 tetramer interface [polypeptide binding]; other site 271848012573 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 271848012574 allantoicase; Provisional; Region: PRK13257 271848012575 Allantoicase repeat; Region: Allantoicase; pfam03561 271848012576 Allantoicase repeat; Region: Allantoicase; pfam03561 271848012577 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 271848012578 Predicted membrane protein [Function unknown]; Region: COG3748 271848012579 Protein of unknown function (DUF989); Region: DUF989; pfam06181 271848012580 Cytochrome c; Region: Cytochrom_C; cl11414 271848012581 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 271848012582 active site 271848012583 homotetramer interface [polypeptide binding]; other site 271848012584 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 271848012585 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 271848012586 active site 271848012587 putative substrate binding pocket [chemical binding]; other site 271848012588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848012589 Helix-turn-helix domains; Region: HTH; cl00088 271848012590 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 271848012591 putative substrate binding pocket [chemical binding]; other site 271848012592 putative dimerization interface [polypeptide binding]; other site 271848012593 Dodecin; Region: Dodecin; cl01328 271848012594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848012595 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271848012596 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271848012597 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848012598 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 271848012599 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 271848012600 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271848012601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848012602 TPR motif; other site 271848012603 PspA/IM30 family; Region: PspA_IM30; pfam04012 271848012604 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848012605 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 271848012606 Transglycosylase; Region: Transgly; cl07896 271848012607 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848012608 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 271848012609 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 271848012610 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271848012611 tetramer interface [polypeptide binding]; other site 271848012612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012613 catalytic residue [active] 271848012614 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 271848012615 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 271848012616 metal binding site [ion binding]; metal-binding site 271848012617 putative dimer interface [polypeptide binding]; other site 271848012618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848012619 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 271848012620 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 271848012621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848012622 ATP binding site [chemical binding]; other site 271848012623 putative Mg++ binding site [ion binding]; other site 271848012624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848012625 nucleotide binding region [chemical binding]; other site 271848012626 ATP-binding site [chemical binding]; other site 271848012627 TRCF domain; Region: TRCF; cl04088 271848012628 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 271848012629 substrate binding site; other site 271848012630 dimer interface; other site 271848012631 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 271848012632 homotrimer interaction site [polypeptide binding]; other site 271848012633 zinc binding site [ion binding]; other site 271848012634 CDP-binding sites; other site 271848012635 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 271848012636 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848012637 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 271848012638 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 271848012639 dimer interface [polypeptide binding]; other site 271848012640 decamer (pentamer of dimers) interface [polypeptide binding]; other site 271848012641 catalytic triad [active] 271848012642 peroxidatic and resolving cysteines [active] 271848012643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848012644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848012645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848012646 dimer interface [polypeptide binding]; other site 271848012647 phosphorylation site [posttranslational modification] 271848012648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848012649 ATP binding site [chemical binding]; other site 271848012650 Mg2+ binding site [ion binding]; other site 271848012651 G-X-G motif; other site 271848012652 osmolarity response regulator; Provisional; Region: ompR; PRK09468 271848012653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848012654 active site 271848012655 phosphorylation site [posttranslational modification] 271848012656 intermolecular recognition site; other site 271848012657 dimerization interface [polypeptide binding]; other site 271848012658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848012659 DNA binding site [nucleotide binding] 271848012660 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 271848012661 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 271848012662 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 271848012663 active site lid residues [active] 271848012664 substrate binding pocket [chemical binding]; other site 271848012665 catalytic residues [active] 271848012666 substrate-Mg2+ binding site; other site 271848012667 aspartate-rich region 1; other site 271848012668 aspartate-rich region 2; other site 271848012669 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848012670 PAAR motif; Region: PAAR_motif; cl15808 271848012671 MEKHLA domain; Region: MEKHLA; pfam08670 271848012672 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 271848012673 PLD-like domain; Region: PLDc_2; pfam13091 271848012674 putative active site [active] 271848012675 catalytic site [active] 271848012676 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 271848012677 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848012678 trimer interface [polypeptide binding]; other site 271848012679 eyelet of channel; other site 271848012680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848012681 dimerization interface [polypeptide binding]; other site 271848012682 DNA binding residues [nucleotide binding] 271848012683 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 271848012684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848012685 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 271848012686 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848012687 Helix-turn-helix domains; Region: HTH; cl00088 271848012688 Helix-turn-helix domains; Region: HTH; cl00088 271848012689 Glycerate kinase family; Region: Gly_kinase; cl00841 271848012690 trigger factor; Provisional; Region: tig; PRK01490 271848012691 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 271848012692 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 271848012693 Clp protease; Region: CLP_protease; pfam00574 271848012694 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 271848012695 oligomer interface [polypeptide binding]; other site 271848012696 active site residues [active] 271848012697 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 271848012698 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 271848012699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848012700 Walker A motif; other site 271848012701 ATP binding site [chemical binding]; other site 271848012702 Walker B motif; other site 271848012703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848012704 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 271848012705 Found in ATP-dependent protease La (LON); Region: LON; smart00464 271848012706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848012707 Walker A motif; other site 271848012708 ATP binding site [chemical binding]; other site 271848012709 Walker B motif; other site 271848012710 arginine finger; other site 271848012711 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 271848012712 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 271848012713 30S subunit binding site; other site 271848012714 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848012715 periplasmic folding chaperone; Provisional; Region: PRK10788 271848012716 SurA N-terminal domain; Region: SurA_N_3; cl07813 271848012717 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271848012718 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 271848012719 active site 271848012720 catalytic triad [active] 271848012721 oxyanion hole [active] 271848012722 switch loop; other site 271848012723 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 271848012724 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 271848012725 Walker A/P-loop; other site 271848012726 ATP binding site [chemical binding]; other site 271848012727 Q-loop/lid; other site 271848012728 ABC transporter signature motif; other site 271848012729 Walker B; other site 271848012730 D-loop; other site 271848012731 H-loop/switch region; other site 271848012732 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 271848012733 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 271848012734 active site 271848012735 dimer interface [polypeptide binding]; other site 271848012736 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 271848012737 dimer interface [polypeptide binding]; other site 271848012738 active site 271848012739 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 271848012740 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 271848012741 putative substrate binding site [chemical binding]; other site 271848012742 putative ATP binding site [chemical binding]; other site 271848012743 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 271848012744 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 271848012745 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 271848012746 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 271848012747 dimerization interface [polypeptide binding]; other site 271848012748 ATP binding site [chemical binding]; other site 271848012749 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 271848012750 dimerization interface [polypeptide binding]; other site 271848012751 ATP binding site [chemical binding]; other site 271848012752 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 271848012753 putative active site [active] 271848012754 catalytic triad [active] 271848012755 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 271848012756 PPIC-type PPIASE domain; Region: Rotamase; cl08278 271848012757 BolA-like protein; Region: BolA; cl00386 271848012758 Intracellular septation protein A; Region: IspA; cl01098 271848012759 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 271848012760 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 271848012761 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 271848012762 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 271848012763 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 271848012764 AMP-binding enzyme; Region: AMP-binding; cl15778 271848012765 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848012766 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848012767 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 271848012768 substrate binding site [chemical binding]; other site 271848012769 oxyanion hole (OAH) forming residues; other site 271848012770 trimer interface [polypeptide binding]; other site 271848012771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848012772 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848012773 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848012774 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 271848012775 catalytic triad [active] 271848012776 metal binding site [ion binding]; metal-binding site 271848012777 conserved cis-peptide bond; other site 271848012778 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 271848012779 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848012780 dimer interface [polypeptide binding]; other site 271848012781 active site 271848012782 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 271848012783 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848012784 CoenzymeA binding site [chemical binding]; other site 271848012785 subunit interaction site [polypeptide binding]; other site 271848012786 PHB binding site; other site 271848012787 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 271848012788 Prostaglandin dehydrogenases; Region: PGDH; cd05288 271848012789 NAD(P) binding site [chemical binding]; other site 271848012790 substrate binding site [chemical binding]; other site 271848012791 dimer interface [polypeptide binding]; other site 271848012792 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848012793 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848012794 substrate binding pocket [chemical binding]; other site 271848012795 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848012796 NRDE protein; Region: NRDE; cl01315 271848012797 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 271848012798 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 271848012799 YceG-like family; Region: YceG; pfam02618 271848012800 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 271848012801 dimerization interface [polypeptide binding]; other site 271848012802 thymidylate kinase; Validated; Region: tmk; PRK00698 271848012803 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 271848012804 TMP-binding site; other site 271848012805 ATP-binding site [chemical binding]; other site 271848012806 DNA polymerase III subunit delta'; Validated; Region: PRK06964 271848012807 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848012808 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 271848012809 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848012810 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 271848012811 active site 271848012812 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 271848012813 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 271848012814 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 271848012815 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271848012816 Predicted ATPase [General function prediction only]; Region: COG4637 271848012817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848012818 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 271848012819 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848012820 putative ADP-binding pocket [chemical binding]; other site 271848012821 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 271848012822 Domain of unknown function DUF221; Region: DUF221; pfam02714 271848012823 psiF repeat; Region: PsiF_repeat; pfam07769 271848012824 psiF repeat; Region: PsiF_repeat; pfam07769 271848012825 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 271848012826 active site 271848012827 homodimer interface [polypeptide binding]; other site 271848012828 homotetramer interface [polypeptide binding]; other site 271848012829 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 271848012830 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848012831 tartronate semialdehyde reductase; Provisional; Region: PRK15059 271848012832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848012833 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 271848012834 glyoxylate carboligase; Provisional; Region: PRK11269 271848012835 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848012836 PYR/PP interface [polypeptide binding]; other site 271848012837 dimer interface [polypeptide binding]; other site 271848012838 TPP binding site [chemical binding]; other site 271848012839 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271848012840 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 271848012841 TPP-binding site [chemical binding]; other site 271848012842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848012843 Helix-turn-helix domains; Region: HTH; cl00088 271848012844 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848012845 putative effector binding pocket; other site 271848012846 dimerization interface [polypeptide binding]; other site 271848012847 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848012848 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848012849 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848012850 active site 271848012851 metal binding site [ion binding]; metal-binding site 271848012852 RNA polymerase sigma factor; Provisional; Region: PRK12533 271848012853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848012854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848012855 DNA binding residues [nucleotide binding] 271848012856 Putative zinc-finger; Region: zf-HC2; cl15806 271848012857 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 271848012858 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 271848012859 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 271848012860 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 271848012861 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 271848012862 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 271848012863 replicative DNA helicase; Provisional; Region: PRK07004 271848012864 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 271848012865 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 271848012866 Walker A motif; other site 271848012867 ATP binding site [chemical binding]; other site 271848012868 Walker B motif; other site 271848012869 DNA binding loops [nucleotide binding] 271848012870 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 271848012871 Phosphate transporter family; Region: PHO4; cl00396 271848012872 NlpC/P60 family; Region: NLPC_P60; cl11438 271848012873 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 271848012874 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 271848012875 putative active site [active] 271848012876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848012877 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271848012878 catalytic triad [active] 271848012879 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 271848012880 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 271848012881 putative active site [active] 271848012882 putative catalytic site [active] 271848012883 putative Zn binding site [ion binding]; other site 271848012884 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 271848012885 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 271848012886 NAD binding site [chemical binding]; other site 271848012887 substrate binding site [chemical binding]; other site 271848012888 active site 271848012889 putative formyltransferase; Provisional; Region: PRK06988 271848012890 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 271848012891 active site 271848012892 substrate binding site [chemical binding]; other site 271848012893 cosubstrate binding site; other site 271848012894 catalytic site [active] 271848012895 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 271848012896 active site 271848012897 hexamer interface [polypeptide binding]; other site 271848012898 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 271848012899 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 271848012900 Ligand binding site; other site 271848012901 Putative Catalytic site; other site 271848012902 DXD motif; other site 271848012903 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 271848012904 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271848012905 inhibitor-cofactor binding pocket; inhibition site 271848012906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012907 catalytic residue [active] 271848012908 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 271848012909 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 271848012910 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 271848012911 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 271848012912 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 271848012913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848012914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012915 homodimer interface [polypeptide binding]; other site 271848012916 catalytic residue [active] 271848012917 homoserine dehydrogenase; Provisional; Region: PRK06349 271848012918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848012919 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 271848012920 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 271848012921 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 271848012922 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 271848012923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012924 catalytic residue [active] 271848012925 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 271848012926 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 271848012927 dimer interface [polypeptide binding]; other site 271848012928 putative functional site; other site 271848012929 putative MPT binding site; other site 271848012930 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 271848012931 MoaE interaction surface [polypeptide binding]; other site 271848012932 MoeB interaction surface [polypeptide binding]; other site 271848012933 thiocarboxylated glycine; other site 271848012934 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 271848012935 MoaE homodimer interface [polypeptide binding]; other site 271848012936 MoaD interaction [polypeptide binding]; other site 271848012937 active site residues [active] 271848012938 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 271848012939 apolar tunnel; other site 271848012940 heme binding site [chemical binding]; other site 271848012941 dimerization interface [polypeptide binding]; other site 271848012942 Helix-turn-helix domains; Region: HTH; cl00088 271848012943 Rrf2 family protein; Region: rrf2_super; TIGR00738 271848012944 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 271848012945 Clp amino terminal domain; Region: Clp_N; pfam02861 271848012946 Clp amino terminal domain; Region: Clp_N; pfam02861 271848012947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848012948 Walker A motif; other site 271848012949 ATP binding site [chemical binding]; other site 271848012950 Walker B motif; other site 271848012951 arginine finger; other site 271848012952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848012953 Walker A motif; other site 271848012954 ATP binding site [chemical binding]; other site 271848012955 Walker B motif; other site 271848012956 arginine finger; other site 271848012957 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848012958 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 271848012959 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 271848012960 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 271848012961 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 271848012962 DNA binding residues [nucleotide binding] 271848012963 putative dimer interface [polypeptide binding]; other site 271848012964 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848012965 lipoyl synthase; Provisional; Region: PRK12928 271848012966 multidrug efflux protein; Reviewed; Region: PRK01766 271848012967 MatE; Region: MatE; cl10513 271848012968 MatE; Region: MatE; cl10513 271848012969 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 271848012970 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 271848012971 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 271848012972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848012973 putative substrate translocation pore; other site 271848012974 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848012975 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 271848012976 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271848012977 DNA binding residues [nucleotide binding] 271848012978 transcription termination factor Rho; Provisional; Region: rho; PRK09376 271848012979 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 271848012980 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 271848012981 RNA binding site [nucleotide binding]; other site 271848012982 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 271848012983 multimer interface [polypeptide binding]; other site 271848012984 Walker A motif; other site 271848012985 ATP binding site [chemical binding]; other site 271848012986 Walker B motif; other site 271848012987 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848012988 catalytic residues [active] 271848012989 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 271848012990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848012991 Walker A motif; other site 271848012992 ATP binding site [chemical binding]; other site 271848012993 Walker B motif; other site 271848012994 arginine finger; other site 271848012995 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 271848012996 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 271848012997 recombination protein RecR; Reviewed; Region: recR; PRK00076 271848012998 RecR protein; Region: RecR; pfam02132 271848012999 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 271848013000 putative active site [active] 271848013001 putative metal-binding site [ion binding]; other site 271848013002 tetramer interface [polypeptide binding]; other site 271848013003 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848013004 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848013005 Survival protein SurE; Region: SurE; cl00448 271848013006 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 271848013007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848013008 S-adenosylmethionine binding site [chemical binding]; other site 271848013009 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848013010 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 271848013011 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 271848013012 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271848013013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848013014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848013015 DNA binding residues [nucleotide binding] 271848013016 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 271848013017 active site 271848013018 catalytic site [active] 271848013019 substrate binding site [chemical binding]; other site 271848013020 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 271848013021 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 271848013022 putative catalytic site [active] 271848013023 putative metal binding site [ion binding]; other site 271848013024 putative phosphate binding site [ion binding]; other site 271848013025 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 271848013026 putative catalytic site [active] 271848013027 putative phosphate binding site [ion binding]; other site 271848013028 putative metal binding site [ion binding]; other site 271848013029 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 271848013030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848013031 YccA-like proteins; Region: YccA_like; cd10433 271848013032 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 271848013033 active site 271848013034 multimer interface [polypeptide binding]; other site 271848013035 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 271848013036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848013037 FeS/SAM binding site; other site 271848013038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848013039 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 271848013040 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 271848013041 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 271848013042 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 271848013043 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 271848013044 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 271848013045 dimer interface [polypeptide binding]; other site 271848013046 motif 1; other site 271848013047 active site 271848013048 motif 2; other site 271848013049 motif 3; other site 271848013050 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 271848013051 anticodon binding site; other site 271848013052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 271848013053 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 271848013054 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 271848013055 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 271848013056 Trp docking motif [polypeptide binding]; other site 271848013057 active site 271848013058 GTP-binding protein Der; Reviewed; Region: PRK00093 271848013059 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 271848013060 G1 box; other site 271848013061 GTP/Mg2+ binding site [chemical binding]; other site 271848013062 Switch I region; other site 271848013063 G2 box; other site 271848013064 Switch II region; other site 271848013065 G3 box; other site 271848013066 G4 box; other site 271848013067 G5 box; other site 271848013068 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 271848013069 G1 box; other site 271848013070 GTP/Mg2+ binding site [chemical binding]; other site 271848013071 Switch I region; other site 271848013072 G2 box; other site 271848013073 G3 box; other site 271848013074 Switch II region; other site 271848013075 G4 box; other site 271848013076 G5 box; other site 271848013077 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 271848013078 Sm1 motif; other site 271848013079 intra - hexamer interaction site; other site 271848013080 inter - hexamer interaction site [polypeptide binding]; other site 271848013081 nucleotide binding pocket [chemical binding]; other site 271848013082 Sm2 motif; other site 271848013083 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 271848013084 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 271848013085 HflX GTPase family; Region: HflX; cd01878 271848013086 G1 box; other site 271848013087 GTP/Mg2+ binding site [chemical binding]; other site 271848013088 Switch I region; other site 271848013089 G2 box; other site 271848013090 G3 box; other site 271848013091 Switch II region; other site 271848013092 G4 box; other site 271848013093 G5 box; other site 271848013094 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 271848013095 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 271848013096 HflK protein; Region: hflK; TIGR01933 271848013097 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 271848013098 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 271848013099 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 271848013100 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 271848013101 dimer interface [polypeptide binding]; other site 271848013102 motif 1; other site 271848013103 active site 271848013104 motif 2; other site 271848013105 motif 3; other site 271848013106 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 271848013107 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 271848013108 GDP-binding site [chemical binding]; other site 271848013109 ACT binding site; other site 271848013110 IMP binding site; other site 271848013111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848013112 active site 271848013113 K+ potassium transporter; Region: K_trans; cl15781 271848013114 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 271848013115 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 271848013116 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 271848013117 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 271848013118 RNA binding site [nucleotide binding]; other site 271848013119 Protein of unknown function (DUF465); Region: DUF465; cl01070 271848013120 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 271848013121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013123 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 271848013124 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 271848013125 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848013126 RNA binding surface [nucleotide binding]; other site 271848013127 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 271848013128 active site 271848013129 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 271848013130 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 271848013131 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 271848013132 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 271848013133 putative acyltransferase; Provisional; Region: PRK05790 271848013134 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848013135 dimer interface [polypeptide binding]; other site 271848013136 active site 271848013137 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 271848013138 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 271848013139 NAD(P) binding site [chemical binding]; other site 271848013140 homotetramer interface [polypeptide binding]; other site 271848013141 homodimer interface [polypeptide binding]; other site 271848013142 active site 271848013143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 271848013144 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 271848013145 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 271848013146 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 271848013147 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 271848013148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848013149 FeS/SAM binding site; other site 271848013150 TRAM domain; Region: TRAM; cl01282 271848013151 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848013152 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 271848013153 substrate binding site [chemical binding]; other site 271848013154 ATP binding site [chemical binding]; other site 271848013155 beta-ketothiolase; Provisional; Region: PRK09051 271848013156 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848013157 dimer interface [polypeptide binding]; other site 271848013158 active site 271848013159 cystathionine beta-lyase; Provisional; Region: PRK07050 271848013160 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848013161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848013162 catalytic residue [active] 271848013163 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 271848013164 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 271848013165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848013166 motif II; other site 271848013167 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 271848013168 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 271848013169 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013170 Walker A/P-loop; other site 271848013171 ATP binding site [chemical binding]; other site 271848013172 Q-loop/lid; other site 271848013173 ABC transporter signature motif; other site 271848013174 Walker B; other site 271848013175 D-loop; other site 271848013176 H-loop/switch region; other site 271848013177 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 271848013178 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 271848013179 AsmA-like C-terminal region; Region: AsmA_2; cl15864 271848013180 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 271848013181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013182 Walker A/P-loop; other site 271848013183 ATP binding site [chemical binding]; other site 271848013184 Q-loop/lid; other site 271848013185 ABC transporter signature motif; other site 271848013186 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271848013187 Walker B; other site 271848013188 D-loop; other site 271848013189 H-loop/switch region; other site 271848013190 ABC transporter; Region: ABC_tran_2; pfam12848 271848013191 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271848013192 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848013193 trimer interface [polypeptide binding]; other site 271848013194 eyelet of channel; other site 271848013195 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 271848013196 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848013197 NAD binding site [chemical binding]; other site 271848013198 catalytic residues [active] 271848013199 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 271848013200 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 271848013201 FMN binding site [chemical binding]; other site 271848013202 substrate binding site [chemical binding]; other site 271848013203 putative catalytic residue [active] 271848013204 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 271848013205 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 271848013206 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 271848013207 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 271848013208 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 271848013209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848013210 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 271848013211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013212 Walker A/P-loop; other site 271848013213 ATP binding site [chemical binding]; other site 271848013214 Q-loop/lid; other site 271848013215 ABC transporter signature motif; other site 271848013216 Walker B; other site 271848013217 D-loop; other site 271848013218 H-loop/switch region; other site 271848013219 TOBE domain; Region: TOBE_2; cl01440 271848013220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013221 dimer interface [polypeptide binding]; other site 271848013222 conserved gate region; other site 271848013223 putative PBP binding loops; other site 271848013224 ABC-ATPase subunit interface; other site 271848013225 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 271848013226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013227 dimer interface [polypeptide binding]; other site 271848013228 conserved gate region; other site 271848013229 putative PBP binding loops; other site 271848013230 ABC-ATPase subunit interface; other site 271848013231 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 271848013232 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 271848013233 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 271848013234 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848013235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848013236 PAS fold; Region: PAS_4; pfam08448 271848013237 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 271848013238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013239 Walker A motif; other site 271848013240 ATP binding site [chemical binding]; other site 271848013241 Walker B motif; other site 271848013242 arginine finger; other site 271848013243 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 271848013244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848013245 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848013246 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271848013247 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848013248 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848013249 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848013250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848013251 Helix-turn-helix domains; Region: HTH; cl00088 271848013252 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 271848013253 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 271848013254 Cl- selectivity filter; other site 271848013255 Cl- binding residues [ion binding]; other site 271848013256 pore gating glutamate residue; other site 271848013257 dimer interface [polypeptide binding]; other site 271848013258 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 271848013259 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 271848013260 Helix-turn-helix domains; Region: HTH; cl00088 271848013261 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 271848013262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848013263 dimerization interface [polypeptide binding]; other site 271848013264 SdpI/YhfL protein family; Region: SdpI; pfam13630 271848013265 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848013266 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 271848013267 substrate binding site [chemical binding]; other site 271848013268 ATP binding site [chemical binding]; other site 271848013269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848013270 D-galactonate transporter; Region: 2A0114; TIGR00893 271848013271 putative substrate translocation pore; other site 271848013272 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 271848013273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013274 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848013275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848013276 DNA binding site [nucleotide binding] 271848013277 domain linker motif; other site 271848013278 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 271848013279 putative ligand binding site [chemical binding]; other site 271848013280 putative dimerization interface [polypeptide binding]; other site 271848013281 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 271848013282 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 271848013283 PGDYG protein; Region: PGDYG; pfam14083 271848013284 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848013285 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 271848013286 Helix-turn-helix domains; Region: HTH; cl00088 271848013287 AsnC family; Region: AsnC_trans_reg; pfam01037 271848013288 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 271848013289 Double zinc ribbon; Region: DZR; pfam12773 271848013290 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 271848013291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013292 AAA domain; Region: AAA_33; pfam13671 271848013293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013294 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 271848013295 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 271848013296 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 271848013297 YCII-related domain; Region: YCII; cl00999 271848013298 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 271848013299 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 271848013300 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271848013301 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 271848013302 FMN-binding domain; Region: FMN_bind; cl01081 271848013303 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 271848013304 4Fe-4S binding domain; Region: Fer4_5; pfam12801 271848013305 4Fe-4S binding domain; Region: Fer4_5; pfam12801 271848013306 Cytochrome c; Region: Cytochrom_C; cl11414 271848013307 NosL; Region: NosL; cl01769 271848013308 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848013309 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848013310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013311 Walker A/P-loop; other site 271848013312 ATP binding site [chemical binding]; other site 271848013313 Q-loop/lid; other site 271848013314 ABC transporter signature motif; other site 271848013315 Walker B; other site 271848013316 D-loop; other site 271848013317 H-loop/switch region; other site 271848013318 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 271848013319 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 271848013320 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 271848013321 nitrous-oxide reductase; Validated; Region: PRK02888 271848013322 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848013323 ApbE family; Region: ApbE; cl00643 271848013324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848013325 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 271848013326 Walker A/P-loop; other site 271848013327 ATP binding site [chemical binding]; other site 271848013328 Q-loop/lid; other site 271848013329 ABC transporter signature motif; other site 271848013330 Walker B; other site 271848013331 D-loop; other site 271848013332 H-loop/switch region; other site 271848013333 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848013334 dihydroxyacetone kinase; Provisional; Region: PRK14479 271848013335 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 271848013336 DAK2 domain; Region: Dak2; cl03685 271848013337 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 271848013338 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 271848013339 hydrophobic ligand binding site; other site 271848013340 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 271848013341 iron-sulfur cluster [ion binding]; other site 271848013342 [2Fe-2S] cluster binding site [ion binding]; other site 271848013343 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271848013344 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 271848013345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013346 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 271848013347 putative alcohol dehydrogenase; Provisional; Region: PRK09860 271848013348 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 271848013349 dimer interface [polypeptide binding]; other site 271848013350 active site 271848013351 metal binding site [ion binding]; metal-binding site 271848013352 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 271848013353 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 271848013354 active site 271848013355 catalytic residues [active] 271848013356 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 271848013357 putative dimerization interface [polypeptide binding]; other site 271848013358 putative ligand binding site [chemical binding]; other site 271848013359 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848013360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848013361 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 271848013362 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 271848013363 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 271848013364 putative ligand binding site [chemical binding]; other site 271848013365 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 271848013366 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 271848013367 Walker A/P-loop; other site 271848013368 ATP binding site [chemical binding]; other site 271848013369 Q-loop/lid; other site 271848013370 ABC transporter signature motif; other site 271848013371 Walker B; other site 271848013372 D-loop; other site 271848013373 H-loop/switch region; other site 271848013374 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 271848013375 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848013376 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848013377 TM-ABC transporter signature motif; other site 271848013378 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 271848013379 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 271848013380 putative ligand binding site [chemical binding]; other site 271848013381 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848013382 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 271848013383 Walker A/P-loop; other site 271848013384 ATP binding site [chemical binding]; other site 271848013385 Q-loop/lid; other site 271848013386 ABC transporter signature motif; other site 271848013387 Walker B; other site 271848013388 D-loop; other site 271848013389 H-loop/switch region; other site 271848013390 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 271848013391 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848013392 TM-ABC transporter signature motif; other site 271848013393 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848013394 TM-ABC transporter signature motif; other site 271848013395 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848013396 MULE transposase domain; Region: MULE; pfam10551 271848013397 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 271848013398 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848013399 MULE transposase domain; Region: MULE; pfam10551 271848013400 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848013401 Transposase domain (DUF772); Region: DUF772; pfam05598 271848013402 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848013403 Helix-turn-helix domains; Region: HTH; cl00088 271848013404 Winged helix-turn helix; Region: HTH_29; pfam13551 271848013405 Helix-turn-helix domains; Region: HTH; cl00088 271848013406 Lipoxygenase; Region: Lipoxygenase; pfam00305 271848013407 short chain dehydrogenase; Validated; Region: PRK05855 271848013408 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848013409 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848013410 peptidase domain interface [polypeptide binding]; other site 271848013411 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848013412 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848013413 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 271848013414 peptide synthase; Provisional; Region: PRK12316 271848013415 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 271848013416 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013417 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 271848013418 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 271848013419 putative active site [active] 271848013420 putative substrate binding site [chemical binding]; other site 271848013421 ATP binding site [chemical binding]; other site 271848013422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848013423 active site 271848013424 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848013425 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848013426 active site 271848013427 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848013428 NADH(P)-binding; Region: NAD_binding_10; pfam13460 271848013429 putative NADP binding site [chemical binding]; other site 271848013430 active site 271848013431 peptide synthase; Provisional; Region: PRK12316 271848013432 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013433 peptide synthase; Provisional; Region: PRK12467 271848013434 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848013435 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013436 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013437 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013438 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013439 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013440 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 271848013441 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013442 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013443 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848013444 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848013445 active site 271848013446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013447 NAD(P) binding site [chemical binding]; other site 271848013448 active site 271848013449 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013450 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848013451 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848013452 active site 271848013453 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848013454 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 271848013455 putative NADP binding site [chemical binding]; other site 271848013456 active site 271848013457 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013458 acyl-CoA synthetase; Validated; Region: PRK05850 271848013459 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013460 Condensation domain; Region: Condensation; pfam00668 271848013461 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848013462 Nonribosomal peptide synthase; Region: NRPS; pfam08415 271848013463 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013464 acyl-CoA synthetase; Validated; Region: PRK06178 271848013465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848013466 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848013467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848013468 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848013469 trimer interface [polypeptide binding]; other site 271848013470 eyelet of channel; other site 271848013471 Cupin domain; Region: Cupin_2; cl09118 271848013472 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848013473 EamA-like transporter family; Region: EamA; cl01037 271848013474 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848013475 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 271848013476 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848013477 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848013478 dimer interface [polypeptide binding]; other site 271848013479 putative CheW interface [polypeptide binding]; other site 271848013480 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 271848013481 AMP-binding domain protein; Validated; Region: PRK07529 271848013482 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013483 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 271848013484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848013485 S-adenosylmethionine binding site [chemical binding]; other site 271848013486 NMT1-like family; Region: NMT1_2; cl15260 271848013487 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 271848013488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848013489 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 271848013490 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 271848013491 Walker A/P-loop; other site 271848013492 ATP binding site [chemical binding]; other site 271848013493 Q-loop/lid; other site 271848013494 ABC transporter signature motif; other site 271848013495 Walker B; other site 271848013496 D-loop; other site 271848013497 H-loop/switch region; other site 271848013498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848013499 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 271848013500 Amidinotransferase; Region: Amidinotransf; cl12043 271848013501 ornithine carbamoyltransferase; Validated; Region: PRK02102 271848013502 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271848013503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013504 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 271848013505 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 271848013506 putative substrate binding site [chemical binding]; other site 271848013507 nucleotide binding site [chemical binding]; other site 271848013508 nucleotide binding site [chemical binding]; other site 271848013509 homodimer interface [polypeptide binding]; other site 271848013510 short chain dehydrogenase; Provisional; Region: PRK09291 271848013511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013512 NAD(P) binding site [chemical binding]; other site 271848013513 active site 271848013514 Domain of unknown function (DUF336); Region: DUF336; cl01249 271848013515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848013516 Helix-turn-helix domains; Region: HTH; cl00088 271848013517 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 271848013518 putative effector binding pocket; other site 271848013519 putative dimerization interface [polypeptide binding]; other site 271848013520 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 271848013521 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 271848013522 C-terminal domain interface [polypeptide binding]; other site 271848013523 GSH binding site (G-site) [chemical binding]; other site 271848013524 dimer interface [polypeptide binding]; other site 271848013525 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 271848013526 dimer interface [polypeptide binding]; other site 271848013527 N-terminal domain interface [polypeptide binding]; other site 271848013528 Helix-turn-helix domains; Region: HTH; cl00088 271848013529 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848013530 putative cyanate transporter; Provisional; Region: cynX; PRK09705 271848013531 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 271848013532 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271848013533 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 271848013534 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 271848013535 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 271848013536 CbiD; Region: CbiD; cl00828 271848013537 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271848013538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848013539 precorrin-3B synthase; Region: CobG; TIGR02435 271848013540 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848013541 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 271848013542 Precorrin-8X methylmutase; Region: CbiC; pfam02570 271848013543 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271848013544 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 271848013545 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 271848013546 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 271848013547 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 271848013548 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 271848013549 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 271848013550 active site 271848013551 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 271848013552 chitin/cellulose binding site [chemical binding]; other site 271848013553 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 271848013554 chitin/cellulose binding site [chemical binding]; other site 271848013555 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 271848013556 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848013557 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 271848013558 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271848013559 metal ion-dependent adhesion site (MIDAS); other site 271848013560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013561 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848013562 Walker A motif; other site 271848013563 ATP binding site [chemical binding]; other site 271848013564 Walker B motif; other site 271848013565 arginine finger; other site 271848013566 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 271848013567 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 271848013568 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 271848013569 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 271848013570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013571 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 271848013572 High-affinity nickel-transport protein; Region: NicO; cl00964 271848013573 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 271848013574 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 271848013575 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 271848013576 homodimer interface [polypeptide binding]; other site 271848013577 Walker A motif; other site 271848013578 ATP binding site [chemical binding]; other site 271848013579 hydroxycobalamin binding site [chemical binding]; other site 271848013580 Walker B motif; other site 271848013581 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 271848013582 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 271848013583 catalytic triad [active] 271848013584 Inclusion body protein; Region: PixA; pfam12306 271848013585 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 271848013586 catalytic site [active] 271848013587 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 271848013588 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848013589 N-terminal plug; other site 271848013590 ligand-binding site [chemical binding]; other site 271848013591 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 271848013592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013593 peptide synthase; Provisional; Region: PRK12467 271848013594 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848013595 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848013596 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013597 peptide synthase; Validated; Region: PRK05691 271848013598 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013599 peptide synthase; Provisional; Region: PRK12467 271848013600 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848013601 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013602 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013603 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013604 peptide synthase; Provisional; Region: PRK12316 271848013605 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848013606 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013607 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013608 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 271848013609 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013610 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848013611 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 271848013612 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 271848013613 Walker A/P-loop; other site 271848013614 ATP binding site [chemical binding]; other site 271848013615 Q-loop/lid; other site 271848013616 ABC transporter signature motif; other site 271848013617 Walker B; other site 271848013618 D-loop; other site 271848013619 H-loop/switch region; other site 271848013620 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 271848013621 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 271848013622 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 271848013623 siderophore binding site; other site 271848013624 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 271848013625 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 271848013626 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 271848013627 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 271848013628 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 271848013629 ABC-ATPase subunit interface; other site 271848013630 dimer interface [polypeptide binding]; other site 271848013631 putative PBP binding regions; other site 271848013632 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 271848013633 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271848013634 Walker A/P-loop; other site 271848013635 ATP binding site [chemical binding]; other site 271848013636 Q-loop/lid; other site 271848013637 ABC transporter signature motif; other site 271848013638 Walker B; other site 271848013639 D-loop; other site 271848013640 H-loop/switch region; other site 271848013641 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848013642 MbtH-like protein; Region: MbtH; cl01279 271848013643 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 271848013644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848013645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 271848013646 short chain dehydrogenase; Provisional; Region: PRK07060 271848013647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013648 NAD(P) binding site [chemical binding]; other site 271848013649 active site 271848013650 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 271848013651 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 271848013652 N- and C-terminal domain interface [polypeptide binding]; other site 271848013653 putative active site [active] 271848013654 catalytic site [active] 271848013655 metal binding site [ion binding]; metal-binding site 271848013656 putative xylulose binding site [chemical binding]; other site 271848013657 putative ATP binding site [chemical binding]; other site 271848013658 putative homodimer interface [polypeptide binding]; other site 271848013659 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 271848013660 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 271848013661 NAD(P) binding site [chemical binding]; other site 271848013662 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848013663 TM-ABC transporter signature motif; other site 271848013664 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848013665 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 271848013666 Walker A/P-loop; other site 271848013667 ATP binding site [chemical binding]; other site 271848013668 Q-loop/lid; other site 271848013669 ABC transporter signature motif; other site 271848013670 Walker B; other site 271848013671 D-loop; other site 271848013672 H-loop/switch region; other site 271848013673 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 271848013674 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 271848013675 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848013676 putative ligand binding site [chemical binding]; other site 271848013677 Cupin domain; Region: Cupin_2; cl09118 271848013678 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848013679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848013680 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 271848013681 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 271848013682 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271848013683 Ligand Binding Site [chemical binding]; other site 271848013684 Molecular Tunnel; other site 271848013685 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 271848013686 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013687 Walker A/P-loop; other site 271848013688 ATP binding site [chemical binding]; other site 271848013689 Q-loop/lid; other site 271848013690 ABC transporter signature motif; other site 271848013691 Walker B; other site 271848013692 D-loop; other site 271848013693 H-loop/switch region; other site 271848013694 Fimbrial protein; Region: Fimbrial; cl01416 271848013695 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 271848013696 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 271848013697 multidrug efflux protein; Reviewed; Region: PRK09577 271848013698 Protein export membrane protein; Region: SecD_SecF; cl14618 271848013699 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 271848013700 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848013701 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848013702 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 271848013703 Helix-turn-helix domains; Region: HTH; cl00088 271848013704 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 271848013705 Peptidase family M23; Region: Peptidase_M23; pfam01551 271848013706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013707 dimer interface [polypeptide binding]; other site 271848013708 conserved gate region; other site 271848013709 putative PBP binding loops; other site 271848013710 ABC-ATPase subunit interface; other site 271848013711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013712 dimer interface [polypeptide binding]; other site 271848013713 conserved gate region; other site 271848013714 putative PBP binding loops; other site 271848013715 ABC-ATPase subunit interface; other site 271848013716 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848013717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848013718 substrate binding pocket [chemical binding]; other site 271848013719 membrane-bound complex binding site; other site 271848013720 hinge residues; other site 271848013721 TadE-like protein; Region: TadE; cl10688 271848013722 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 271848013723 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848013724 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848013725 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 271848013726 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 271848013727 ATP binding site [chemical binding]; other site 271848013728 Walker A motif; other site 271848013729 hexamer interface [polypeptide binding]; other site 271848013730 Walker B motif; other site 271848013731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 271848013732 active site 271848013733 phosphorylation site [posttranslational modification] 271848013734 intermolecular recognition site; other site 271848013735 dimerization interface [polypeptide binding]; other site 271848013736 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 271848013737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013738 Type IV pili component [Cell motility and secretion]; Region: COG5461; cl02279 271848013739 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 271848013740 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 271848013741 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848013742 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 271848013743 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 271848013744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013745 Walker A/P-loop; other site 271848013746 ATP binding site [chemical binding]; other site 271848013747 Q-loop/lid; other site 271848013748 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 271848013749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848013750 putative substrate translocation pore; other site 271848013751 SpoVR family protein; Provisional; Region: PRK11767 271848013752 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 271848013753 Uncharacterized conserved protein [Function unknown]; Region: COG2718 271848013754 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271848013755 PrkA family serine protein kinase; Provisional; Region: PRK15455 271848013756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013757 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 271848013758 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 271848013759 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 271848013760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848013761 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848013762 dimer interface [polypeptide binding]; other site 271848013763 putative CheW interface [polypeptide binding]; other site 271848013764 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848013765 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 271848013766 substrate binding site [chemical binding]; other site 271848013767 dimer interface [polypeptide binding]; other site 271848013768 ATP binding site [chemical binding]; other site 271848013769 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848013770 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848013771 DNA binding site [nucleotide binding] 271848013772 domain linker motif; other site 271848013773 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271848013774 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848013775 TM-ABC transporter signature motif; other site 271848013776 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848013777 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 271848013778 Walker A/P-loop; other site 271848013779 ATP binding site [chemical binding]; other site 271848013780 Q-loop/lid; other site 271848013781 ABC transporter signature motif; other site 271848013782 Walker B; other site 271848013783 D-loop; other site 271848013784 H-loop/switch region; other site 271848013785 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 271848013786 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 271848013787 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848013788 ligand binding site [chemical binding]; other site 271848013789 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 271848013790 Helix-turn-helix domains; Region: HTH; cl00088 271848013791 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 271848013792 substrate binding site [chemical binding]; other site 271848013793 dimerization interface [polypeptide binding]; other site 271848013794 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 271848013795 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 271848013796 Walker A/P-loop; other site 271848013797 ATP binding site [chemical binding]; other site 271848013798 Q-loop/lid; other site 271848013799 ABC transporter signature motif; other site 271848013800 Walker B; other site 271848013801 D-loop; other site 271848013802 H-loop/switch region; other site 271848013803 TOBE-like domain; Region: TOBE_3; pfam12857 271848013804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013805 dimer interface [polypeptide binding]; other site 271848013806 conserved gate region; other site 271848013807 putative PBP binding loops; other site 271848013808 ABC-ATPase subunit interface; other site 271848013809 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 271848013810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013811 dimer interface [polypeptide binding]; other site 271848013812 conserved gate region; other site 271848013813 putative PBP binding loops; other site 271848013814 ABC-ATPase subunit interface; other site 271848013815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848013816 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271848013817 LexA repressor; Validated; Region: PRK00215 271848013818 Helix-turn-helix domains; Region: HTH; cl00088 271848013819 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 271848013820 Catalytic site [active] 271848013821 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 271848013822 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848013823 Ligand Binding Site [chemical binding]; other site 271848013824 nodulation ABC transporter NodI; Provisional; Region: PRK13537 271848013825 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 271848013826 Walker A/P-loop; other site 271848013827 ATP binding site [chemical binding]; other site 271848013828 Q-loop/lid; other site 271848013829 ABC transporter signature motif; other site 271848013830 Walker B; other site 271848013831 D-loop; other site 271848013832 H-loop/switch region; other site 271848013833 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848013834 Predicted permease; Region: DUF318; pfam03773 271848013835 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 271848013836 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848013837 active site 271848013838 catalytic tetrad [active] 271848013839 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848013840 CoenzymeA binding site [chemical binding]; other site 271848013841 subunit interaction site [polypeptide binding]; other site 271848013842 PHB binding site; other site 271848013843 Helix-turn-helix domains; Region: HTH; cl00088 271848013844 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 271848013845 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 271848013846 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 271848013847 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 271848013848 FMN binding site [chemical binding]; other site 271848013849 active site 271848013850 catalytic residues [active] 271848013851 substrate binding site [chemical binding]; other site 271848013852 TOBE domain; Region: TOBE_2; cl01440 271848013853 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271848013854 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 271848013855 Walker A/P-loop; other site 271848013856 ATP binding site [chemical binding]; other site 271848013857 Q-loop/lid; other site 271848013858 ABC transporter signature motif; other site 271848013859 Walker B; other site 271848013860 D-loop; other site 271848013861 H-loop/switch region; other site 271848013862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013863 dimer interface [polypeptide binding]; other site 271848013864 conserved gate region; other site 271848013865 putative PBP binding loops; other site 271848013866 ABC-ATPase subunit interface; other site 271848013867 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 271848013868 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 271848013869 active site 271848013870 dimer interface [polypeptide binding]; other site 271848013871 non-prolyl cis peptide bond; other site 271848013872 insertion regions; other site 271848013873 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 271848013874 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848013875 substrate binding site [chemical binding]; other site 271848013876 oxyanion hole (OAH) forming residues; other site 271848013877 trimer interface [polypeptide binding]; other site 271848013878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 271848013879 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 271848013880 Domain of unknown function (DUF336); Region: DUF336; cl01249 271848013881 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 271848013882 nudix motif; other site 271848013883 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848013884 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 271848013885 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 271848013886 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848013887 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 271848013888 quinone interaction residues [chemical binding]; other site 271848013889 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 271848013890 active site 271848013891 catalytic residues [active] 271848013892 FMN binding site [chemical binding]; other site 271848013893 substrate binding site [chemical binding]; other site 271848013894 cystine transporter subunit; Provisional; Region: PRK11260 271848013895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848013896 substrate binding pocket [chemical binding]; other site 271848013897 membrane-bound complex binding site; other site 271848013898 hinge residues; other site 271848013899 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848013900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013901 dimer interface [polypeptide binding]; other site 271848013902 conserved gate region; other site 271848013903 putative PBP binding loops; other site 271848013904 ABC-ATPase subunit interface; other site 271848013905 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271848013906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848013907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848013908 DNA-binding site [nucleotide binding]; DNA binding site 271848013909 FCD domain; Region: FCD; cl11656 271848013910 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 271848013911 tetramer (dimer of dimers) interface [polypeptide binding]; other site 271848013912 active site 271848013913 dimer interface [polypeptide binding]; other site 271848013914 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 271848013915 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271848013916 amidase catalytic site [active] 271848013917 Zn binding residues [ion binding]; other site 271848013918 substrate binding site [chemical binding]; other site 271848013919 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 271848013920 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 271848013921 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 271848013922 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 271848013923 ribonuclease R; Region: RNase_R; TIGR02063 271848013924 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 271848013925 RNB domain; Region: RNB; pfam00773 271848013926 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 271848013927 RNA binding site [nucleotide binding]; other site 271848013928 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848013929 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848013930 dimer interface [polypeptide binding]; other site 271848013931 putative CheW interface [polypeptide binding]; other site 271848013932 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 271848013933 metal binding site [ion binding]; metal-binding site 271848013934 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 271848013935 Sulfate transporter family; Region: Sulfate_transp; cl15842 271848013936 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 271848013937 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 271848013938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 271848013939 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848013940 putative sialic acid transporter; Region: 2A0112; TIGR00891 271848013941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848013942 putative substrate translocation pore; other site 271848013943 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 271848013944 Helix-turn-helix domains; Region: HTH; cl00088 271848013945 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 271848013946 AMP-binding enzyme; Region: AMP-binding; cl15778 271848013947 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848013948 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 271848013949 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 271848013950 Sm1 motif; other site 271848013951 D1 - D2 interaction site; other site 271848013952 D3 - B interaction site; other site 271848013953 Hfq - Hfq interaction site; other site 271848013954 RNA binding pocket [nucleotide binding]; other site 271848013955 Sm2 motif; other site 271848013956 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 271848013957 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848013958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013959 Walker A motif; other site 271848013960 ATP binding site [chemical binding]; other site 271848013961 Walker B motif; other site 271848013962 arginine finger; other site 271848013963 Helix-turn-helix domains; Region: HTH; cl00088 271848013964 Predicted membrane protein [Function unknown]; Region: COG4655 271848013965 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 271848013966 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 271848013967 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 271848013968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271848013969 TPR motif; other site 271848013970 binding surface 271848013971 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848013972 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 271848013973 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 271848013974 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 271848013975 ATP binding site [chemical binding]; other site 271848013976 Walker A motif; other site 271848013977 hexamer interface [polypeptide binding]; other site 271848013978 Walker B motif; other site 271848013979 Response regulator receiver domain; Region: Response_reg; pfam00072 271848013980 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 271848013981 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 271848013982 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 271848013983 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848013984 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 271848013985 TadE-like protein; Region: TadE; cl10688 271848013986 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 271848013987 Flp/Fap pilin component; Region: Flp_Fap; cl01585 271848013988 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 271848013989 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271848013990 Surface antigen; Region: Bac_surface_Ag; cl03097 271848013991 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 271848013992 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848013993 Predicted ATPase [General function prediction only]; Region: COG1485 271848013994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848013995 Walker A/P-loop; other site 271848013996 ATP binding site [chemical binding]; other site 271848013997 Q-loop/lid; other site 271848013998 Walker B; other site 271848013999 D-loop; other site 271848014000 H-loop/switch region; other site 271848014001 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 271848014002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848014003 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271848014004 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 271848014005 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848014006 E3 interaction surface; other site 271848014007 lipoyl attachment site [posttranslational modification]; other site 271848014008 e3 binding domain; Region: E3_binding; pfam02817 271848014009 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 271848014010 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 271848014011 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 271848014012 TPP-binding site [chemical binding]; other site 271848014013 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 271848014014 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 271848014015 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 271848014016 G1 box; other site 271848014017 putative GEF interaction site [polypeptide binding]; other site 271848014018 GTP/Mg2+ binding site [chemical binding]; other site 271848014019 Switch I region; other site 271848014020 G2 box; other site 271848014021 G3 box; other site 271848014022 Switch II region; other site 271848014023 G4 box; other site 271848014024 G5 box; other site 271848014025 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 271848014026 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 271848014027 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848014028 Helix-turn-helix domains; Region: HTH; cl00088 271848014029 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848014030 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 271848014031 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848014032 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848014033 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848014034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014035 putative substrate translocation pore; other site 271848014036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014037 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 271848014038 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 271848014039 RNA binding site [nucleotide binding]; other site 271848014040 active site 271848014041 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 271848014042 Ribosome-binding factor A; Region: RBFA; cl00542 271848014043 translation initiation factor IF-2; Validated; Region: infB; PRK05306 271848014044 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 271848014045 translation initiation factor IF-2; Region: IF-2; TIGR00487 271848014046 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 271848014047 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 271848014048 G1 box; other site 271848014049 putative GEF interaction site [polypeptide binding]; other site 271848014050 GTP/Mg2+ binding site [chemical binding]; other site 271848014051 Switch I region; other site 271848014052 G2 box; other site 271848014053 G3 box; other site 271848014054 Switch II region; other site 271848014055 G4 box; other site 271848014056 G5 box; other site 271848014057 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 271848014058 Translation-initiation factor 2; Region: IF-2; pfam11987 271848014059 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 271848014060 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 271848014061 NusA N-terminal domain; Region: NusA_N; pfam08529 271848014062 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 271848014063 RNA binding site [nucleotide binding]; other site 271848014064 homodimer interface [polypeptide binding]; other site 271848014065 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 271848014066 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 271848014067 G-X-X-G motif; other site 271848014068 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 271848014069 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 271848014070 ribosome maturation protein RimP; Reviewed; Region: PRK00092 271848014071 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 271848014072 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 271848014073 Sm1 motif; other site 271848014074 predicted subunit interaction site [polypeptide binding]; other site 271848014075 RNA binding pocket [nucleotide binding]; other site 271848014076 Sm2 motif; other site 271848014077 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 271848014078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848014079 RNA binding surface [nucleotide binding]; other site 271848014080 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 271848014081 probable active site [active] 271848014082 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 271848014083 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 271848014084 Helix-turn-helix domains; Region: HTH; cl00088 271848014085 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 271848014086 putative dimerization interface [polypeptide binding]; other site 271848014087 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848014088 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 271848014089 putative active site [active] 271848014090 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 271848014091 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 271848014092 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 271848014093 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 271848014094 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 271848014095 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 271848014096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848014097 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848014098 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848014099 HTH-like domain; Region: HTH_21; pfam13276 271848014100 Integrase core domain; Region: rve; cl01316 271848014101 Integrase core domain; Region: rve_3; cl15866 271848014102 Helix-turn-helix domains; Region: HTH; cl00088 271848014103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848014104 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271848014105 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 271848014106 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271848014107 DNA binding residues [nucleotide binding] 271848014108 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271848014109 IHF dimer interface [polypeptide binding]; other site 271848014110 IHF - DNA interface [nucleotide binding]; other site 271848014111 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 271848014112 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 271848014113 putative tRNA-binding site [nucleotide binding]; other site 271848014114 B3/4 domain; Region: B3_4; cl11458 271848014115 tRNA synthetase B5 domain; Region: B5; cl08394 271848014116 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 271848014117 dimer interface [polypeptide binding]; other site 271848014118 motif 1; other site 271848014119 motif 3; other site 271848014120 motif 2; other site 271848014121 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 271848014122 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 271848014123 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 271848014124 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 271848014125 dimer interface [polypeptide binding]; other site 271848014126 motif 1; other site 271848014127 active site 271848014128 motif 2; other site 271848014129 motif 3; other site 271848014130 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 271848014131 23S rRNA binding site [nucleotide binding]; other site 271848014132 L21 binding site [polypeptide binding]; other site 271848014133 L13 binding site [polypeptide binding]; other site 271848014134 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 271848014135 translation initiation factor IF-3; Region: infC; TIGR00168 271848014136 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 271848014137 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 271848014138 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 271848014139 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 271848014140 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 271848014141 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 271848014142 active site 271848014143 dimer interface [polypeptide binding]; other site 271848014144 motif 1; other site 271848014145 motif 2; other site 271848014146 motif 3; other site 271848014147 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 271848014148 anticodon binding site; other site 271848014149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 271848014150 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 271848014151 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 271848014152 synthetase active site [active] 271848014153 NTP binding site [chemical binding]; other site 271848014154 metal binding site [ion binding]; metal-binding site 271848014155 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 271848014156 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 271848014157 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 271848014158 homotrimer interaction site [polypeptide binding]; other site 271848014159 putative active site [active] 271848014160 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848014161 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 271848014162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014163 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 271848014164 transcriptional regulator; Provisional; Region: PRK10632 271848014165 Helix-turn-helix domains; Region: HTH; cl00088 271848014166 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848014167 putative effector binding pocket; other site 271848014168 dimerization interface [polypeptide binding]; other site 271848014169 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 271848014170 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 271848014171 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 271848014172 short chain dehydrogenase; Provisional; Region: PRK07041 271848014173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014174 NAD(P) binding site [chemical binding]; other site 271848014175 active site 271848014176 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 271848014177 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 271848014178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848014179 PAS domain; Region: PAS_9; pfam13426 271848014180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848014181 DNA binding residues [nucleotide binding] 271848014182 dimerization interface [polypeptide binding]; other site 271848014183 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271848014184 active site 271848014185 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 271848014186 classical (c) SDRs; Region: SDR_c; cd05233 271848014187 NAD(P) binding site [chemical binding]; other site 271848014188 active site 271848014189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014190 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 271848014191 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 271848014192 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 271848014193 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 271848014194 Tetramer interface [polypeptide binding]; other site 271848014195 active site 271848014196 FMN-binding site [chemical binding]; other site 271848014197 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 271848014198 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271848014199 putative acyl-acceptor binding pocket; other site 271848014200 FOG: CBS domain [General function prediction only]; Region: COG0517 271848014201 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 271848014202 Protein of unknown function (DUF962); Region: DUF962; cl01879 271848014203 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 271848014204 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271848014205 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 271848014206 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848014207 FAD binding domain; Region: FAD_binding_4; pfam01565 271848014208 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848014209 active site 271848014210 metal binding site [ion binding]; metal-binding site 271848014211 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848014212 transcriptional regulator; Provisional; Region: PRK10632 271848014213 Helix-turn-helix domains; Region: HTH; cl00088 271848014214 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848014215 putative effector binding pocket; other site 271848014216 dimerization interface [polypeptide binding]; other site 271848014217 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848014218 Fusaric acid resistance protein family; Region: FUSC; pfam04632 271848014219 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 271848014220 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 271848014221 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 271848014222 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848014223 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848014224 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848014225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848014226 dimer interface [polypeptide binding]; other site 271848014227 putative CheW interface [polypeptide binding]; other site 271848014228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014229 putative substrate translocation pore; other site 271848014230 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 271848014231 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 271848014232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848014233 Family description; Region: UvrD_C_2; cl15862 271848014234 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 271848014235 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 271848014236 HIGH motif; other site 271848014237 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271848014238 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 271848014239 active site 271848014240 KMSKS motif; other site 271848014241 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 271848014242 tRNA binding surface [nucleotide binding]; other site 271848014243 anticodon binding site; other site 271848014244 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 271848014245 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 271848014246 active site 271848014247 tetramer interface; other site 271848014248 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 271848014249 CHASE2 domain; Region: CHASE2; cl01732 271848014250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 271848014251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271848014252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848014253 ATP binding site [chemical binding]; other site 271848014254 Mg2+ binding site [ion binding]; other site 271848014255 G-X-G motif; other site 271848014256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 271848014257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848014258 FecR protein; Region: FecR; pfam04773 271848014259 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848014260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848014261 active site 271848014262 phosphorylation site [posttranslational modification] 271848014263 intermolecular recognition site; other site 271848014264 dimerization interface [polypeptide binding]; other site 271848014265 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848014266 DNA binding site [nucleotide binding] 271848014267 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 271848014268 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 271848014269 CPxP motif; other site 271848014270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014271 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 271848014272 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271848014273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014274 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 271848014275 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848014276 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848014277 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848014278 putative active site [active] 271848014279 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 271848014280 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848014281 putative ligand binding site [chemical binding]; other site 271848014282 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848014283 TM-ABC transporter signature motif; other site 271848014284 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848014285 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 271848014286 Walker A/P-loop; other site 271848014287 ATP binding site [chemical binding]; other site 271848014288 Q-loop/lid; other site 271848014289 ABC transporter signature motif; other site 271848014290 Walker B; other site 271848014291 D-loop; other site 271848014292 H-loop/switch region; other site 271848014293 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848014294 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 271848014295 substrate binding site [chemical binding]; other site 271848014296 ATP binding site [chemical binding]; other site 271848014297 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 271848014298 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 271848014299 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848014300 PYR/PP interface [polypeptide binding]; other site 271848014301 dimer interface [polypeptide binding]; other site 271848014302 TPP binding site [chemical binding]; other site 271848014303 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271848014304 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 271848014305 TPP-binding site [chemical binding]; other site 271848014306 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 271848014307 KduI/IolB family; Region: KduI; cl01508 271848014308 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848014309 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271848014310 Walker A/P-loop; other site 271848014311 ATP binding site [chemical binding]; other site 271848014312 Q-loop/lid; other site 271848014313 ABC transporter signature motif; other site 271848014314 Walker B; other site 271848014315 D-loop; other site 271848014316 H-loop/switch region; other site 271848014317 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848014318 TM-ABC transporter signature motif; other site 271848014319 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848014320 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 271848014321 Walker A/P-loop; other site 271848014322 ATP binding site [chemical binding]; other site 271848014323 Q-loop/lid; other site 271848014324 ABC transporter signature motif; other site 271848014325 Walker B; other site 271848014326 D-loop; other site 271848014327 H-loop/switch region; other site 271848014328 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848014329 TM-ABC transporter signature motif; other site 271848014330 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271848014331 active site 271848014332 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 271848014333 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 271848014334 putative active site [active] 271848014335 metal binding site [ion binding]; metal-binding site 271848014336 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 271848014337 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 271848014338 nudix motif; other site 271848014339 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271848014340 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271848014341 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848014342 protein binding site [polypeptide binding]; other site 271848014343 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848014344 protein binding site [polypeptide binding]; other site 271848014345 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 271848014346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848014347 Helix-turn-helix domains; Region: HTH; cl00088 271848014348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848014349 dimerization interface [polypeptide binding]; other site 271848014350 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 271848014351 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 271848014352 motif 1; other site 271848014353 active site 271848014354 motif 2; other site 271848014355 motif 3; other site 271848014356 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 271848014357 DHHA1 domain; Region: DHHA1; pfam02272 271848014358 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848014359 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848014360 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 271848014361 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848014362 active site 271848014363 HIGH motif; other site 271848014364 nucleotide binding site [chemical binding]; other site 271848014365 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 271848014366 KMSKS motif; other site 271848014367 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 271848014368 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 271848014369 nudix motif; other site 271848014370 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 271848014371 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 271848014372 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 271848014373 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 271848014374 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 271848014375 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 271848014376 Phosphoesterase family; Region: Phosphoesterase; cl15450 271848014377 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 271848014378 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 271848014379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014380 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 271848014381 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 271848014382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848014383 S-adenosylmethionine binding site [chemical binding]; other site 271848014384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848014385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848014386 active site 271848014387 phosphorylation site [posttranslational modification] 271848014388 intermolecular recognition site; other site 271848014389 dimerization interface [polypeptide binding]; other site 271848014390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848014391 DNA binding residues [nucleotide binding] 271848014392 dimerization interface [polypeptide binding]; other site 271848014393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848014394 dimer interface [polypeptide binding]; other site 271848014395 phosphorylation site [posttranslational modification] 271848014396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848014397 ATP binding site [chemical binding]; other site 271848014398 Mg2+ binding site [ion binding]; other site 271848014399 G-X-G motif; other site 271848014400 Response regulator receiver domain; Region: Response_reg; pfam00072 271848014401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848014402 active site 271848014403 phosphorylation site [posttranslational modification] 271848014404 intermolecular recognition site; other site 271848014405 dimerization interface [polypeptide binding]; other site 271848014406 Spore Coat Protein U domain; Region: SCPU; cl02253 271848014407 Spore Coat Protein U domain; Region: SCPU; cl02253 271848014408 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 271848014409 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 271848014410 PapC C-terminal domain; Region: PapC_C; pfam13953 271848014411 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 271848014412 Spore Coat Protein U domain; Region: SCPU; cl02253 271848014413 Spore Coat Protein U domain; Region: SCPU; cl02253 271848014414 Spore Coat Protein U domain; Region: SCPU; cl02253 271848014415 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848014416 Helix-turn-helix domains; Region: HTH; cl00088 271848014417 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 271848014418 dimerization interface [polypeptide binding]; other site 271848014419 substrate binding pocket [chemical binding]; other site 271848014420 benzoate transport; Region: 2A0115; TIGR00895 271848014421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014422 putative substrate translocation pore; other site 271848014423 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848014424 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848014425 active site 271848014426 H-NS histone family; Region: Histone_HNS; pfam00816 271848014427 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848014428 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 271848014429 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 271848014430 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848014431 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848014432 Integrase core domain; Region: rve; cl01316 271848014433 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848014434 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848014435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848014436 Helix-turn-helix domains; Region: HTH; cl00088 271848014437 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848014438 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848014439 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848014440 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848014441 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848014442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 271848014443 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848014444 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848014445 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848014446 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848014447 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 271848014448 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 271848014449 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848014450 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848014451 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 271848014452 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 271848014453 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848014454 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848014455 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848014456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 271848014457 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848014458 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848014459 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848014460 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848014461 PAAR motif; Region: PAAR_motif; cl15808 271848014462 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848014463 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848014464 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 271848014465 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848014466 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 271848014467 Interdomain contacts; other site 271848014468 Cytokine receptor motif; other site 271848014469 H-NS histone family; Region: Histone_HNS; pfam00816 271848014470 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848014471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014472 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848014473 putative substrate translocation pore; other site 271848014474 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848014475 Helix-turn-helix domains; Region: HTH; cl00088 271848014476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848014477 dimerization interface [polypeptide binding]; other site 271848014478 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848014479 active site 271848014480 DNA binding site [nucleotide binding] 271848014481 Int/Topo IB signature motif; other site 271848014482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 271848014483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848014484 Coenzyme A binding pocket [chemical binding]; other site 271848014485 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848014486 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 271848014487 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 271848014488 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 271848014489 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 271848014490 putative active site [active] 271848014491 putative metal-binding site [ion binding]; other site 271848014492 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 271848014493 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 271848014494 Surface antigen; Region: Bac_surface_Ag; cl03097 271848014495 haemagglutination activity domain; Region: Haemagg_act; cl05436 271848014496 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 271848014497 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 271848014498 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 271848014499 Domain of unknown function (DUF932); Region: DUF932; cl12129 271848014500 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 271848014501 Methyltransferase domain; Region: Methyltransf_27; pfam13708 271848014502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848014503 non-specific DNA binding site [nucleotide binding]; other site 271848014504 salt bridge; other site 271848014505 sequence-specific DNA binding site [nucleotide binding]; other site 271848014506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848014507 S-adenosylmethionine binding site [chemical binding]; other site 271848014508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848014509 non-specific DNA binding site [nucleotide binding]; other site 271848014510 salt bridge; other site 271848014511 sequence-specific DNA binding site [nucleotide binding]; other site 271848014512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 271848014513 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848014514 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848014515 Integrase core domain; Region: rve; cl01316 271848014516 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848014517 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848014518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848014519 Helix-turn-helix domains; Region: HTH; cl00088 271848014520 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 271848014521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848014522 ATP binding site [chemical binding]; other site 271848014523 Mg2+ binding site [ion binding]; other site 271848014524 G-X-G motif; other site 271848014525 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271848014526 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 271848014527 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848014528 ATP binding site [chemical binding]; other site 271848014529 putative Mg++ binding site [ion binding]; other site 271848014530 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 271848014531 Abortive infection C-terminus; Region: Abi_C; pfam14355 271848014532 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 271848014533 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271848014534 HsdM N-terminal domain; Region: HsdM_N; pfam12161 271848014535 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 271848014536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848014537 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848014538 HTH-like domain; Region: HTH_21; pfam13276 271848014539 Integrase core domain; Region: rve; cl01316 271848014540 Integrase core domain; Region: rve_3; cl15866 271848014541 Helix-turn-helix domains; Region: HTH; cl00088 271848014542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848014543 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 271848014544 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 271848014545 catalytic residues [active] 271848014546 catalytic nucleophile [active] 271848014547 Recombinase; Region: Recombinase; pfam07508 271848014548 ParB-like nuclease domain; Region: ParBc; cl02129 271848014549 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848014550 MULE transposase domain; Region: MULE; pfam10551 271848014551 Bacitracin resistance protein BacA; Region: BacA; cl00858 271848014552 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 271848014553 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 271848014554 active site 271848014555 catalytic residues [active] 271848014556 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848014557 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 271848014558 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 271848014559 AMP-binding enzyme; Region: AMP-binding; cl15778 271848014560 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848014561 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 271848014562 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 271848014563 MatE; Region: MatE; cl10513 271848014564 MatE; Region: MatE; cl10513 271848014565 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848014566 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 271848014567 catalytic core [active] 271848014568 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 271848014569 Sec24-related protein; Provisional; Region: PTZ00395 271848014570 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 271848014571 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 271848014572 polyphosphate kinase; Provisional; Region: PRK05443 271848014573 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 271848014574 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 271848014575 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271848014576 putative active site [active] 271848014577 catalytic site [active] 271848014578 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 271848014579 putative domain interface [polypeptide binding]; other site 271848014580 putative active site [active] 271848014581 catalytic site [active] 271848014582 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271848014583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848014584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848014585 dimer interface [polypeptide binding]; other site 271848014586 phosphorylation site [posttranslational modification] 271848014587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848014588 ATP binding site [chemical binding]; other site 271848014589 Mg2+ binding site [ion binding]; other site 271848014590 G-X-G motif; other site 271848014591 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 271848014592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848014593 active site 271848014594 phosphorylation site [posttranslational modification] 271848014595 intermolecular recognition site; other site 271848014596 dimerization interface [polypeptide binding]; other site 271848014597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848014598 DNA binding site [nucleotide binding] 271848014599 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 271848014600 PhoU domain; Region: PhoU; pfam01895 271848014601 PhoU domain; Region: PhoU; pfam01895 271848014602 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 271848014603 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 271848014604 Walker A/P-loop; other site 271848014605 ATP binding site [chemical binding]; other site 271848014606 Q-loop/lid; other site 271848014607 ABC transporter signature motif; other site 271848014608 Walker B; other site 271848014609 D-loop; other site 271848014610 H-loop/switch region; other site 271848014611 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 271848014612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014613 dimer interface [polypeptide binding]; other site 271848014614 conserved gate region; other site 271848014615 putative PBP binding loops; other site 271848014616 ABC-ATPase subunit interface; other site 271848014617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014618 dimer interface [polypeptide binding]; other site 271848014619 conserved gate region; other site 271848014620 putative PBP binding loops; other site 271848014621 ABC-ATPase subunit interface; other site 271848014622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848014623 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 271848014624 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 271848014625 active site 271848014626 substrate binding site [chemical binding]; other site 271848014627 metal binding site [ion binding]; metal-binding site 271848014628 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 271848014629 dihydropteroate synthase; Region: DHPS; TIGR01496 271848014630 substrate binding pocket [chemical binding]; other site 271848014631 dimer interface [polypeptide binding]; other site 271848014632 inhibitor binding site; inhibition site 271848014633 FtsH Extracellular; Region: FtsH_ext; pfam06480 271848014634 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 271848014635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848014636 Walker A motif; other site 271848014637 ATP binding site [chemical binding]; other site 271848014638 Walker B motif; other site 271848014639 arginine finger; other site 271848014640 Peptidase family M41; Region: Peptidase_M41; pfam01434 271848014641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848014642 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 271848014643 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 271848014644 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 271848014645 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 271848014646 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 271848014647 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 271848014648 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 271848014649 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848014650 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848014651 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 271848014652 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848014653 ATP-grasp domain; Region: ATP-grasp_4; cl03087 271848014654 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 271848014655 IMP binding site; other site 271848014656 dimer interface [polypeptide binding]; other site 271848014657 interdomain contacts; other site 271848014658 partial ornithine binding site; other site 271848014659 LysE type translocator; Region: LysE; cl00565 271848014660 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 271848014661 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 271848014662 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 271848014663 catalytic site [active] 271848014664 subunit interface [polypeptide binding]; other site 271848014665 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848014666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848014667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848014668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014669 putative substrate translocation pore; other site 271848014670 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 271848014671 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 271848014672 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848014673 catalytic residue [active] 271848014674 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 271848014675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848014676 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 271848014677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848014678 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 271848014679 RNA/DNA hybrid binding site [nucleotide binding]; other site 271848014680 active site 271848014681 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 271848014682 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 271848014683 active site 271848014684 catalytic site [active] 271848014685 substrate binding site [chemical binding]; other site 271848014686 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 271848014687 proline/glycine betaine transporter; Provisional; Region: PRK10642 271848014688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014689 putative substrate translocation pore; other site 271848014690 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 271848014691 C-terminal domain interface [polypeptide binding]; other site 271848014692 GSH binding site (G-site) [chemical binding]; other site 271848014693 dimer interface [polypeptide binding]; other site 271848014694 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 271848014695 N-terminal domain interface [polypeptide binding]; other site 271848014696 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 271848014697 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271848014698 putative active site [active] 271848014699 catalytic site [active] 271848014700 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848014701 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 271848014702 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 271848014703 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 271848014704 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848014705 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 271848014706 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 271848014707 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 271848014708 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 271848014709 Malonate transporter MadL subunit; Region: MadL; cl04273 271848014710 Helix-turn-helix domains; Region: HTH; cl00088 271848014711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848014712 dimerization interface [polypeptide binding]; other site 271848014713 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 271848014714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014715 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848014716 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 271848014717 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 271848014718 active site 271848014719 substrate-binding site [chemical binding]; other site 271848014720 metal-binding site [ion binding] 271848014721 GTP binding site [chemical binding]; other site 271848014722 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 271848014723 putative dimer interface [polypeptide binding]; other site 271848014724 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 271848014725 putative dimer interface [polypeptide binding]; other site 271848014726 GSCFA family; Region: GSCFA; pfam08885 271848014727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848014728 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 271848014729 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 271848014730 short chain dehydrogenase; Provisional; Region: PRK12744 271848014731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014732 NAD(P) binding site [chemical binding]; other site 271848014733 active site 271848014734 transcriptional regulator; Provisional; Region: PRK10632 271848014735 Helix-turn-helix domains; Region: HTH; cl00088 271848014736 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 271848014737 putative effector binding pocket; other site 271848014738 putative dimerization interface [polypeptide binding]; other site 271848014739 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 271848014740 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 271848014741 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271848014742 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 271848014743 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 271848014744 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 271848014745 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848014746 metal binding site [ion binding]; metal-binding site 271848014747 active site 271848014748 I-site; other site 271848014749 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848014750 trimer interface [polypeptide binding]; other site 271848014751 eyelet of channel; other site 271848014752 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848014753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848014754 DNA binding site [nucleotide binding] 271848014755 domain linker motif; other site 271848014756 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 271848014757 putative dimerization interface [polypeptide binding]; other site 271848014758 putative ligand binding site [chemical binding]; other site 271848014759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848014760 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 271848014761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848014762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848014763 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 271848014764 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848014765 Walker A/P-loop; other site 271848014766 ATP binding site [chemical binding]; other site 271848014767 Q-loop/lid; other site 271848014768 ABC transporter signature motif; other site 271848014769 Walker B; other site 271848014770 D-loop; other site 271848014771 H-loop/switch region; other site 271848014772 TOBE domain; Region: TOBE_2; cl01440 271848014773 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 271848014774 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848014775 active site 271848014776 metal binding site [ion binding]; metal-binding site 271848014777 hexamer interface [polypeptide binding]; other site 271848014778 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848014779 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848014780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014781 EamA-like transporter family; Region: EamA; cl01037 271848014782 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 271848014783 Moco binding site; other site 271848014784 metal coordination site [ion binding]; other site 271848014785 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 271848014786 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 271848014787 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 271848014788 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 271848014789 ThiC-associated domain; Region: ThiC-associated; pfam13667 271848014790 ThiC family; Region: ThiC; cl08031 271848014791 EamA-like transporter family; Region: EamA; cl01037 271848014792 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271848014793 EamA-like transporter family; Region: EamA; cl01037 271848014794 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848014795 RF-1 domain; Region: RF-1; cl02875 271848014796 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 271848014797 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848014798 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 271848014799 Family description; Region: UvrD_C_2; cl15862 271848014800 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 271848014801 Family description; Region: UvrD_C_2; cl15862 271848014802 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 271848014803 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 271848014804 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 271848014805 Predicted membrane protein [Function unknown]; Region: COG1289 271848014806 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 271848014807 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 271848014808 putative proline-specific permease; Provisional; Region: proY; PRK10580 271848014809 Spore germination protein; Region: Spore_permease; cl15802 271848014810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848014811 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 271848014812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014813 dimer interface [polypeptide binding]; other site 271848014814 conserved gate region; other site 271848014815 putative PBP binding loops; other site 271848014816 ABC-ATPase subunit interface; other site 271848014817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848014818 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 271848014819 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 271848014820 Walker A/P-loop; other site 271848014821 ATP binding site [chemical binding]; other site 271848014822 Q-loop/lid; other site 271848014823 ABC transporter signature motif; other site 271848014824 Walker B; other site 271848014825 D-loop; other site 271848014826 H-loop/switch region; other site 271848014827 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848014828 Helix-turn-helix domains; Region: HTH; cl00088 271848014829 AsnC family; Region: AsnC_trans_reg; pfam01037 271848014830 Cysteine dioxygenase type I; Region: CDO_I; cl15835 271848014831 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 271848014832 NADH(P)-binding; Region: NAD_binding_10; pfam13460 271848014833 NAD binding site [chemical binding]; other site 271848014834 putative active site [active] 271848014835 substrate binding site [chemical binding]; other site 271848014836 Predicted transcriptional regulator [Transcription]; Region: COG1959 271848014837 Helix-turn-helix domains; Region: HTH; cl00088 271848014838 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 271848014839 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848014840 Helix-turn-helix domains; Region: HTH; cl00088 271848014841 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848014842 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 271848014843 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848014844 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848014845 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 271848014846 Protein export membrane protein; Region: SecD_SecF; cl14618 271848014847 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 271848014848 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 271848014849 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 271848014850 NADH(P)-binding; Region: NAD_binding_10; pfam13460 271848014851 NAD(P) binding site [chemical binding]; other site 271848014852 putative active site [active] 271848014853 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271848014854 catalytic triad [active] 271848014855 PAS domain; Region: PAS_9; pfam13426 271848014856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848014857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848014858 metal binding site [ion binding]; metal-binding site 271848014859 active site 271848014860 I-site; other site 271848014861 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848014862 HDOD domain; Region: HDOD; pfam08668 271848014863 Cytochrome c; Region: Cytochrom_C; cl11414 271848014864 Cytochrome c; Region: Cytochrom_C; cl11414 271848014865 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 271848014866 Low-spin heme binding site [chemical binding]; other site 271848014867 Subunit I/II interface [polypeptide binding]; other site 271848014868 Putative Q-pathway; other site 271848014869 Putative D-pathway homolog; other site 271848014870 Putative alternate electron transfer pathway; other site 271848014871 Putative water exit pathway; other site 271848014872 Binuclear center (active site) [active] 271848014873 Putative K-pathway homolog; other site 271848014874 Putative proton exit pathway; other site 271848014875 Subunit I/IIa interface [polypeptide binding]; other site 271848014876 Electron transfer pathway; other site 271848014877 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 271848014878 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848014879 Cytochrome c; Region: Cytochrom_C; cl11414 271848014880 Cytochrome c; Region: Cytochrom_C; cl11414 271848014881 Cytochrome c; Region: Cytochrom_C; cl11414 271848014882 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 271848014883 catalytic motif [active] 271848014884 Catalytic residue [active] 271848014885 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 271848014886 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 271848014887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 271848014888 Histidine kinase; Region: HisKA_3; pfam07730 271848014889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848014890 ATP binding site [chemical binding]; other site 271848014891 Mg2+ binding site [ion binding]; other site 271848014892 G-X-G motif; other site 271848014893 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848014894 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 271848014895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014896 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 271848014897 L-serine binding site [chemical binding]; other site 271848014898 ACT domain interface; other site 271848014899 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848014900 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848014901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848014902 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848014903 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 271848014904 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 271848014905 active site 271848014906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848014907 Helix-turn-helix domains; Region: HTH; cl00088 271848014908 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848014909 Integrase core domain; Region: rve; cl01316 271848014910 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848014911 MULE transposase domain; Region: MULE; pfam10551 271848014912 Integrase core domain; Region: rve; cl01316 271848014913 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848014914 enoyl-CoA hydratase; Provisional; Region: PRK05862 271848014915 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848014916 substrate binding site [chemical binding]; other site 271848014917 oxyanion hole (OAH) forming residues; other site 271848014918 trimer interface [polypeptide binding]; other site 271848014919 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848014920 NAD(P) binding site [chemical binding]; other site 271848014921 catalytic residues [active] 271848014922 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 271848014923 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848014924 dimer interface [polypeptide binding]; other site 271848014925 active site 271848014926 enoyl-CoA hydratase; Provisional; Region: PRK08140 271848014927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848014928 substrate binding site [chemical binding]; other site 271848014929 oxyanion hole (OAH) forming residues; other site 271848014930 trimer interface [polypeptide binding]; other site 271848014931 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848014932 CoenzymeA binding site [chemical binding]; other site 271848014933 subunit interaction site [polypeptide binding]; other site 271848014934 PHB binding site; other site 271848014935 AMP-binding enzyme; Region: AMP-binding; cl15778 271848014936 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 271848014937 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 271848014938 MltA specific insert domain; Region: MltA; cl08398 271848014939 3D domain; Region: 3D; cl01439 271848014940 Protein of unknown function (DUF525); Region: DUF525; cl01119 271848014941 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 271848014942 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 271848014943 substrate binding site [chemical binding]; other site 271848014944 hexamer interface [polypeptide binding]; other site 271848014945 metal binding site [ion binding]; metal-binding site 271848014946 phosphoglycolate phosphatase; Provisional; Region: PRK13222 271848014947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848014948 motif II; other site 271848014949 anthranilate synthase component I; Provisional; Region: PRK13565 271848014950 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 271848014951 chorismate binding enzyme; Region: Chorismate_bind; cl10555 271848014952 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 271848014953 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 271848014954 glutamine binding [chemical binding]; other site 271848014955 catalytic triad [active] 271848014956 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 271848014957 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271848014958 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 271848014959 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 271848014960 active site 271848014961 ribulose/triose binding site [chemical binding]; other site 271848014962 phosphate binding site [ion binding]; other site 271848014963 substrate (anthranilate) binding pocket [chemical binding]; other site 271848014964 product (indole) binding pocket [chemical binding]; other site 271848014965 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 271848014966 putative active site [active] 271848014967 putative metal binding residues [ion binding]; other site 271848014968 signature motif; other site 271848014969 putative triphosphate binding site [ion binding]; other site 271848014970 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 271848014971 ligand binding site [chemical binding]; other site 271848014972 active site 271848014973 UGI interface [polypeptide binding]; other site 271848014974 catalytic site [active] 271848014975 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271848014976 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 271848014977 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848014978 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 271848014979 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 271848014980 dimerization domain [polypeptide binding]; other site 271848014981 dimer interface [polypeptide binding]; other site 271848014982 catalytic residues [active] 271848014983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014984 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 271848014985 GTP-binding protein YchF; Reviewed; Region: PRK09601 271848014986 YchF GTPase; Region: YchF; cd01900 271848014987 G1 box; other site 271848014988 GTP/Mg2+ binding site [chemical binding]; other site 271848014989 Switch I region; other site 271848014990 G2 box; other site 271848014991 Switch II region; other site 271848014992 G3 box; other site 271848014993 G4 box; other site 271848014994 G5 box; other site 271848014995 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 271848014996 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 271848014997 Spore germination protein; Region: Spore_permease; cl15802 271848014998 Protein of unknown function (DUF419); Region: DUF419; cl15265 271848014999 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 271848015000 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 271848015001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015002 Walker A/P-loop; other site 271848015003 ATP binding site [chemical binding]; other site 271848015004 Q-loop/lid; other site 271848015005 ABC transporter signature motif; other site 271848015006 Walker B; other site 271848015007 D-loop; other site 271848015008 H-loop/switch region; other site 271848015009 ABC transporter; Region: ABC_tran_2; pfam12848 271848015010 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 271848015011 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 271848015012 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848015013 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 271848015014 catalytic triad [active] 271848015015 conserved cis-peptide bond; other site 271848015016 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 271848015017 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 271848015018 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 271848015019 active site 271848015020 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 271848015021 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 271848015022 tRNA; other site 271848015023 putative tRNA binding site [nucleotide binding]; other site 271848015024 putative NADP binding site [chemical binding]; other site 271848015025 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 271848015026 peptide chain release factor 1; Validated; Region: prfA; PRK00591 271848015027 RF-1 domain; Region: RF-1; cl02875 271848015028 RF-1 domain; Region: RF-1; cl02875 271848015029 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 271848015030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848015031 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 271848015032 putative GSH binding site [chemical binding]; other site 271848015033 catalytic residues [active] 271848015034 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 271848015035 Flavoprotein; Region: Flavoprotein; cl08021 271848015036 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 271848015037 putative active site [active] 271848015038 metal binding site [ion binding]; metal-binding site 271848015039 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 271848015040 Spore germination protein; Region: Spore_permease; cl15802 271848015041 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 271848015042 DNA-binding site [nucleotide binding]; DNA binding site 271848015043 RNA-binding motif; other site 271848015044 putative chaperone; Provisional; Region: PRK11678 271848015045 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 271848015046 putative FMN binding site [chemical binding]; other site 271848015047 D-galactonate transporter; Region: 2A0114; TIGR00893 271848015048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015049 putative substrate translocation pore; other site 271848015050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848015051 Helix-turn-helix domains; Region: HTH; cl00088 271848015052 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 271848015053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848015054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848015055 S-adenosylmethionine binding site [chemical binding]; other site 271848015056 Late embryogenesis abundant protein; Region: LEA_2; cl12118 271848015057 Peptidase family M1; Region: Peptidase_M1; pfam01433 271848015058 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848015059 Zn binding site [ion binding]; other site 271848015060 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 271848015061 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848015062 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848015063 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 271848015064 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39C; cd02419 271848015065 putative active site [active] 271848015066 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271848015067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015068 Walker A/P-loop; other site 271848015069 ATP binding site [chemical binding]; other site 271848015070 Q-loop/lid; other site 271848015071 ABC transporter signature motif; other site 271848015072 Walker B; other site 271848015073 D-loop; other site 271848015074 H-loop/switch region; other site 271848015075 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 271848015076 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 271848015077 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 271848015078 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 271848015079 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 271848015080 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848015081 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848015082 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271848015083 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 271848015084 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 271848015085 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848015086 ligand binding site [chemical binding]; other site 271848015087 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271848015088 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848015089 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848015090 Clp amino terminal domain; Region: Clp_N; pfam02861 271848015091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848015092 Walker A motif; other site 271848015093 ATP binding site [chemical binding]; other site 271848015094 Walker B motif; other site 271848015095 arginine finger; other site 271848015096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848015097 Walker A motif; other site 271848015098 ATP binding site [chemical binding]; other site 271848015099 Walker B motif; other site 271848015100 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 271848015101 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 271848015102 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848015103 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848015104 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848015105 Protein of unknown function (DUF796); Region: DUF796; cl01226 271848015106 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 271848015107 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848015108 Protein of unknown function (DUF770); Region: DUF770; cl01402 271848015109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848015110 TPR motif; other site 271848015111 binding surface 271848015112 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 271848015113 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 271848015114 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848015115 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 271848015116 Integrase core domain; Region: rve; cl01316 271848015117 Stringent starvation protein B; Region: SspB; cl01120 271848015118 stringent starvation protein A; Provisional; Region: sspA; PRK09481 271848015119 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 271848015120 C-terminal domain interface [polypeptide binding]; other site 271848015121 putative GSH binding site (G-site) [chemical binding]; other site 271848015122 dimer interface [polypeptide binding]; other site 271848015123 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 271848015124 dimer interface [polypeptide binding]; other site 271848015125 N-terminal domain interface [polypeptide binding]; other site 271848015126 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 271848015127 cytochrome b; Provisional; Region: CYTB; MTH00145 271848015128 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 271848015129 Qi binding site; other site 271848015130 intrachain domain interface; other site 271848015131 interchain domain interface [polypeptide binding]; other site 271848015132 heme bH binding site [chemical binding]; other site 271848015133 heme bL binding site [chemical binding]; other site 271848015134 Qo binding site; other site 271848015135 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 271848015136 interchain domain interface [polypeptide binding]; other site 271848015137 intrachain domain interface; other site 271848015138 Qi binding site; other site 271848015139 Qo binding site; other site 271848015140 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 271848015141 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 271848015142 [2Fe-2S] cluster binding site [ion binding]; other site 271848015143 Uncharacterized conserved protein [Function unknown]; Region: COG0327 271848015144 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 271848015145 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 271848015146 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 271848015147 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848015148 protein binding site [polypeptide binding]; other site 271848015149 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 271848015150 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 271848015151 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 271848015152 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 271848015153 nucleotide binding site/active site [active] 271848015154 HIT family signature motif; other site 271848015155 catalytic residue [active] 271848015156 Predicted membrane protein [Function unknown]; Region: COG3671 271848015157 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 271848015158 metal binding site [ion binding]; metal-binding site 271848015159 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 271848015160 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 271848015161 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 271848015162 substrate binding site [chemical binding]; other site 271848015163 glutamase interaction surface [polypeptide binding]; other site 271848015164 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 271848015165 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 271848015166 catalytic residues [active] 271848015167 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 271848015168 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 271848015169 putative active site [active] 271848015170 oxyanion strand; other site 271848015171 catalytic triad [active] 271848015172 MarC family integral membrane protein; Region: MarC; cl00919 271848015173 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 271848015174 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 271848015175 putative active site pocket [active] 271848015176 4-fold oligomerization interface [polypeptide binding]; other site 271848015177 metal binding residues [ion binding]; metal-binding site 271848015178 3-fold/trimer interface [polypeptide binding]; other site 271848015179 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 271848015180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848015181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848015182 homodimer interface [polypeptide binding]; other site 271848015183 catalytic residue [active] 271848015184 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 271848015185 histidinol dehydrogenase; Region: hisD; TIGR00069 271848015186 NAD binding site [chemical binding]; other site 271848015187 dimerization interface [polypeptide binding]; other site 271848015188 product binding site; other site 271848015189 substrate binding site [chemical binding]; other site 271848015190 zinc binding site [ion binding]; other site 271848015191 catalytic residues [active] 271848015192 ATP phosphoribosyltransferase; Region: HisG; cl15266 271848015193 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 271848015194 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 271848015195 hinge; other site 271848015196 active site 271848015197 BolA-like protein; Region: BolA; cl00386 271848015198 ABC-2 type transporter; Region: ABC2_membrane; cl11417 271848015199 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848015200 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 271848015201 Walker A/P-loop; other site 271848015202 ATP binding site [chemical binding]; other site 271848015203 Q-loop/lid; other site 271848015204 ABC transporter signature motif; other site 271848015205 Walker B; other site 271848015206 D-loop; other site 271848015207 H-loop/switch region; other site 271848015208 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 271848015209 anti sigma factor interaction site; other site 271848015210 regulatory phosphorylation site [posttranslational modification]; other site 271848015211 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 271848015212 VacJ like lipoprotein; Region: VacJ; cl01073 271848015213 mce related protein; Region: MCE; pfam02470 271848015214 Permease; Region: Permease; cl00510 271848015215 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 271848015216 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 271848015217 Walker A/P-loop; other site 271848015218 ATP binding site [chemical binding]; other site 271848015219 Q-loop/lid; other site 271848015220 ABC transporter signature motif; other site 271848015221 Walker B; other site 271848015222 D-loop; other site 271848015223 H-loop/switch region; other site 271848015224 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 271848015225 thiamine phosphate binding site [chemical binding]; other site 271848015226 active site 271848015227 pyrophosphate binding site [ion binding]; other site 271848015228 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 271848015229 ThiS interaction site; other site 271848015230 putative active site [active] 271848015231 tetramer interface [polypeptide binding]; other site 271848015232 Ubiquitin-like proteins; Region: UBQ; cl00155 271848015233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848015234 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 271848015235 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 271848015236 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 271848015237 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 271848015238 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 271848015239 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 271848015240 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 271848015241 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 271848015242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848015243 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 271848015244 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 271848015245 active site 271848015246 dimer interface [polypeptide binding]; other site 271848015247 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 271848015248 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 271848015249 active site 271848015250 FMN binding site [chemical binding]; other site 271848015251 substrate binding site [chemical binding]; other site 271848015252 3Fe-4S cluster binding site [ion binding]; other site 271848015253 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 271848015254 domain interface; other site 271848015255 Transposase IS200 like; Region: Y1_Tnp; cl00848 271848015256 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 271848015257 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 271848015258 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 271848015259 active site 271848015260 catalytic site [active] 271848015261 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 271848015262 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 271848015263 Walker A/P-loop; other site 271848015264 ATP binding site [chemical binding]; other site 271848015265 Q-loop/lid; other site 271848015266 ABC transporter signature motif; other site 271848015267 Walker B; other site 271848015268 D-loop; other site 271848015269 H-loop/switch region; other site 271848015270 TOBE domain; Region: TOBE_2; cl01440 271848015271 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 271848015272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848015273 dimer interface [polypeptide binding]; other site 271848015274 conserved gate region; other site 271848015275 putative PBP binding loops; other site 271848015276 ABC-ATPase subunit interface; other site 271848015277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848015278 dimer interface [polypeptide binding]; other site 271848015279 conserved gate region; other site 271848015280 putative PBP binding loops; other site 271848015281 ABC-ATPase subunit interface; other site 271848015282 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 271848015283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848015284 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 271848015285 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271848015286 Zn2+ binding site [ion binding]; other site 271848015287 Mg2+ binding site [ion binding]; other site 271848015288 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 271848015289 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 271848015290 active site 271848015291 dimer interface [polypeptide binding]; other site 271848015292 metal binding site [ion binding]; metal-binding site 271848015293 shikimate kinase; Reviewed; Region: aroK; PRK00131 271848015294 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 271848015295 ADP binding site [chemical binding]; other site 271848015296 magnesium binding site [ion binding]; other site 271848015297 putative shikimate binding site; other site 271848015298 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 271848015299 Secretin and TonB N terminus short domain; Region: STN; cl06624 271848015300 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848015301 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848015302 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 271848015303 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 271848015304 Transglycosylase; Region: Transgly; cl07896 271848015305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 271848015306 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 271848015307 putative iron binding site [ion binding]; other site 271848015308 diaminopimelate decarboxylase; Region: lysA; TIGR01048 271848015309 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 271848015310 active site 271848015311 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848015312 substrate binding site [chemical binding]; other site 271848015313 catalytic residues [active] 271848015314 dimer interface [polypeptide binding]; other site 271848015315 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 271848015316 TMAO/DMSO reductase; Reviewed; Region: PRK05363 271848015317 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 271848015318 Moco binding site; other site 271848015319 metal coordination site [ion binding]; other site 271848015320 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 271848015321 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 271848015322 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 271848015323 Cytochrome c; Region: Cytochrom_C; cl11414 271848015324 Cytochrome c; Region: Cytochrom_C; cl11414 271848015325 Predicted GTPase [General function prediction only]; Region: COG0218 271848015326 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 271848015327 G1 box; other site 271848015328 GTP/Mg2+ binding site [chemical binding]; other site 271848015329 Switch I region; other site 271848015330 G2 box; other site 271848015331 G3 box; other site 271848015332 Switch II region; other site 271848015333 G4 box; other site 271848015334 G5 box; other site 271848015335 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 271848015336 dimer interface [polypeptide binding]; other site 271848015337 active site 271848015338 aspartate-rich active site metal binding site; other site 271848015339 allosteric magnesium binding site [ion binding]; other site 271848015340 Schiff base residues; other site 271848015341 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 271848015342 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 271848015343 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 271848015344 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 271848015345 DsbD alpha interface [polypeptide binding]; other site 271848015346 catalytic residues [active] 271848015347 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 271848015348 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 271848015349 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 271848015350 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 271848015351 alphaNTD homodimer interface [polypeptide binding]; other site 271848015352 alphaNTD - beta interaction site [polypeptide binding]; other site 271848015353 alphaNTD - beta' interaction site [polypeptide binding]; other site 271848015354 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 271848015355 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 271848015356 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 271848015357 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848015358 RNA binding surface [nucleotide binding]; other site 271848015359 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 271848015360 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 271848015361 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 271848015362 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 271848015363 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 271848015364 rRNA binding site [nucleotide binding]; other site 271848015365 predicted 30S ribosome binding site; other site 271848015366 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 271848015367 SecY translocase; Region: SecY; pfam00344 271848015368 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 271848015369 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 271848015370 23S rRNA binding site [nucleotide binding]; other site 271848015371 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 271848015372 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 271848015373 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 271848015374 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 271848015375 5S rRNA interface [nucleotide binding]; other site 271848015376 L27 interface [polypeptide binding]; other site 271848015377 23S rRNA interface [nucleotide binding]; other site 271848015378 L5 interface [polypeptide binding]; other site 271848015379 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 271848015380 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 271848015381 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 271848015382 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 271848015383 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 271848015384 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 271848015385 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 271848015386 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 271848015387 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 271848015388 KOW motif; Region: KOW; cl00354 271848015389 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 271848015390 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 271848015391 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 271848015392 23S rRNA interface [nucleotide binding]; other site 271848015393 putative translocon interaction site; other site 271848015394 signal recognition particle (SRP54) interaction site; other site 271848015395 L23 interface [polypeptide binding]; other site 271848015396 trigger factor interaction site; other site 271848015397 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 271848015398 23S rRNA interface [nucleotide binding]; other site 271848015399 5S rRNA interface [nucleotide binding]; other site 271848015400 putative antibiotic binding site [chemical binding]; other site 271848015401 L25 interface [polypeptide binding]; other site 271848015402 L27 interface [polypeptide binding]; other site 271848015403 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 271848015404 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 271848015405 G-X-X-G motif; other site 271848015406 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 271848015407 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 271848015408 putative translocon binding site; other site 271848015409 protein-rRNA interface [nucleotide binding]; other site 271848015410 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 271848015411 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 271848015412 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 271848015413 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 271848015414 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 271848015415 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 271848015416 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 271848015417 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 271848015418 elongation factor Tu; Reviewed; Region: PRK00049 271848015419 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 271848015420 G1 box; other site 271848015421 GEF interaction site [polypeptide binding]; other site 271848015422 GTP/Mg2+ binding site [chemical binding]; other site 271848015423 Switch I region; other site 271848015424 G2 box; other site 271848015425 G3 box; other site 271848015426 Switch II region; other site 271848015427 G4 box; other site 271848015428 G5 box; other site 271848015429 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 271848015430 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 271848015431 Antibiotic Binding Site [chemical binding]; other site 271848015432 elongation factor G; Reviewed; Region: PRK00007 271848015433 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 271848015434 G1 box; other site 271848015435 putative GEF interaction site [polypeptide binding]; other site 271848015436 GTP/Mg2+ binding site [chemical binding]; other site 271848015437 Switch I region; other site 271848015438 G2 box; other site 271848015439 G3 box; other site 271848015440 Switch II region; other site 271848015441 G4 box; other site 271848015442 G5 box; other site 271848015443 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 271848015444 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 271848015445 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 271848015446 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 271848015447 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 271848015448 S17 interaction site [polypeptide binding]; other site 271848015449 S8 interaction site; other site 271848015450 16S rRNA interaction site [nucleotide binding]; other site 271848015451 streptomycin interaction site [chemical binding]; other site 271848015452 23S rRNA interaction site [nucleotide binding]; other site 271848015453 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 271848015454 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 271848015455 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848015456 ATP binding site [chemical binding]; other site 271848015457 putative Mg++ binding site [ion binding]; other site 271848015458 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848015459 nucleotide binding region [chemical binding]; other site 271848015460 ATP-binding site [chemical binding]; other site 271848015461 RQC domain; Region: RQC; cl09632 271848015462 HRDC domain; Region: HRDC; cl02578 271848015463 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 271848015464 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 271848015465 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 271848015466 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 271848015467 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 271848015468 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 271848015469 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 271848015470 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 271848015471 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 271848015472 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 271848015473 DNA binding site [nucleotide binding] 271848015474 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 271848015475 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 271848015476 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 271848015477 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 271848015478 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 271848015479 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 271848015480 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 271848015481 RPB11 interaction site [polypeptide binding]; other site 271848015482 RPB12 interaction site [polypeptide binding]; other site 271848015483 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 271848015484 RPB3 interaction site [polypeptide binding]; other site 271848015485 RPB1 interaction site [polypeptide binding]; other site 271848015486 RPB11 interaction site [polypeptide binding]; other site 271848015487 RPB10 interaction site [polypeptide binding]; other site 271848015488 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 271848015489 peripheral dimer interface [polypeptide binding]; other site 271848015490 core dimer interface [polypeptide binding]; other site 271848015491 L10 interface [polypeptide binding]; other site 271848015492 L11 interface [polypeptide binding]; other site 271848015493 putative EF-Tu interaction site [polypeptide binding]; other site 271848015494 putative EF-G interaction site [polypeptide binding]; other site 271848015495 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 271848015496 23S rRNA interface [nucleotide binding]; other site 271848015497 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 271848015498 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 271848015499 mRNA/rRNA interface [nucleotide binding]; other site 271848015500 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 271848015501 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 271848015502 23S rRNA interface [nucleotide binding]; other site 271848015503 L7/L12 interface [polypeptide binding]; other site 271848015504 putative thiostrepton binding site; other site 271848015505 L25 interface [polypeptide binding]; other site 271848015506 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 271848015507 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 271848015508 putative homodimer interface [polypeptide binding]; other site 271848015509 KOW motif; Region: KOW; cl00354 271848015510 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 271848015511 elongation factor Tu; Reviewed; Region: PRK00049 271848015512 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 271848015513 G1 box; other site 271848015514 GEF interaction site [polypeptide binding]; other site 271848015515 GTP/Mg2+ binding site [chemical binding]; other site 271848015516 Switch I region; other site 271848015517 G2 box; other site 271848015518 G3 box; other site 271848015519 Switch II region; other site 271848015520 G4 box; other site 271848015521 G5 box; other site 271848015522 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 271848015523 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 271848015524 Antibiotic Binding Site [chemical binding]; other site 271848015525 Integrase core domain; Region: rve; cl01316 271848015526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848015527 Helix-turn-helix domains; Region: HTH; cl00088 271848015528 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848015529 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 271848015530 active site 271848015531 catalytic triad [active] 271848015532 oxyanion hole [active] 271848015533 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 271848015534 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 271848015535 Phenylacetic acid degradation B; Region: PaaB; cl01371 271848015536 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 271848015537 Domain of unknown function DUF59; Region: DUF59; cl00941 271848015538 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 271848015539 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 271848015540 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 271848015541 FAD binding pocket [chemical binding]; other site 271848015542 FAD binding motif [chemical binding]; other site 271848015543 phosphate binding motif [ion binding]; other site 271848015544 beta-alpha-beta structure motif; other site 271848015545 NAD(p) ribose binding residues [chemical binding]; other site 271848015546 NAD binding pocket [chemical binding]; other site 271848015547 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 271848015548 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848015549 catalytic loop [active] 271848015550 iron binding site [ion binding]; other site 271848015551 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 271848015552 Protein of unknown function; Region: DUF3658; pfam12395 271848015553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848015554 Helix-turn-helix domains; Region: HTH; cl00088 271848015555 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 271848015556 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848015557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848015558 putative DNA binding site [nucleotide binding]; other site 271848015559 putative Zn2+ binding site [ion binding]; other site 271848015560 AsnC family; Region: AsnC_trans_reg; pfam01037 271848015561 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 271848015562 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 271848015563 dimer interface [polypeptide binding]; other site 271848015564 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 271848015565 active site 271848015566 Fe binding site [ion binding]; other site 271848015567 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 271848015568 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 271848015569 dimer interface [polypeptide binding]; other site 271848015570 PYR/PP interface [polypeptide binding]; other site 271848015571 TPP binding site [chemical binding]; other site 271848015572 substrate binding site [chemical binding]; other site 271848015573 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 271848015574 TPP-binding site; other site 271848015575 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 271848015576 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 271848015577 Malic enzyme, N-terminal domain; Region: malic; pfam00390 271848015578 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 271848015579 putative NAD(P) binding site [chemical binding]; other site 271848015580 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 271848015581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848015582 active site 271848015583 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 271848015584 substrate binding site [chemical binding]; other site 271848015585 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 271848015586 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 271848015587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848015588 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 271848015589 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 271848015590 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 271848015591 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271848015592 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848015593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848015594 Helix-turn-helix domains; Region: HTH; cl00088 271848015595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848015596 dimerization interface [polypeptide binding]; other site 271848015597 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848015598 LysE type translocator; Region: LysE; cl00565 271848015599 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271848015600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848015601 Ubiquitin-like proteins; Region: UBQ; cl00155 271848015602 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 271848015603 Protein of unknown function DUF82; Region: DUF82; pfam01927 271848015604 putative proline-specific permease; Provisional; Region: proY; PRK10580 271848015605 Spore germination protein; Region: Spore_permease; cl15802 271848015606 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848015607 MULE transposase domain; Region: MULE; pfam10551 271848015608 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848015609 active site 271848015610 DNA binding site [nucleotide binding] 271848015611 Int/Topo IB signature motif; other site 271848015612 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 271848015613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848015614 non-specific DNA binding site [nucleotide binding]; other site 271848015615 salt bridge; other site 271848015616 sequence-specific DNA binding site [nucleotide binding]; other site 271848015617 multiple promoter invertase; Provisional; Region: mpi; PRK13413 271848015618 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 271848015619 catalytic residues [active] 271848015620 catalytic nucleophile [active] 271848015621 Presynaptic Site I dimer interface [polypeptide binding]; other site 271848015622 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 271848015623 Synaptic Flat tetramer interface [polypeptide binding]; other site 271848015624 Synaptic Site I dimer interface [polypeptide binding]; other site 271848015625 DNA binding site [nucleotide binding] 271848015626 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848015627 DNA-binding interface [nucleotide binding]; DNA binding site 271848015628 AAA domain; Region: AAA_21; pfam13304 271848015629 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 271848015630 ABC transporter signature motif; other site 271848015631 Walker B; other site 271848015632 D-loop; other site 271848015633 H-loop/switch region; other site 271848015634 Uncharacterized conserved protein [Function unknown]; Region: COG4983 271848015635 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 271848015636 AAA domain; Region: AAA_25; pfam13481 271848015637 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015638 Walker A motif; other site 271848015639 ATP binding site [chemical binding]; other site 271848015640 Walker B motif; other site 271848015641 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848015642 MULE transposase domain; Region: MULE; pfam10551 271848015643 Predicted helicase [General function prediction only]; Region: COG4889 271848015644 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848015645 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848015646 Integrase core domain; Region: rve; cl01316 271848015647 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848015648 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 271848015649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848015650 Helix-turn-helix domains; Region: HTH; cl00088 271848015651 Restriction endonuclease; Region: Mrr_cat; cl00516 271848015652 Predicted helicase [General function prediction only]; Region: COG4889 271848015653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848015654 ATP binding site [chemical binding]; other site 271848015655 putative Mg++ binding site [ion binding]; other site 271848015656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015657 Cytochrome c; Region: Cytochrom_C; cl11414 271848015658 outer membrane lipoprotein; Provisional; Region: PRK11023 271848015659 BON domain; Region: BON; cl02771 271848015660 BON domain; Region: BON; cl02771 271848015661 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 271848015662 dimer interface [polypeptide binding]; other site 271848015663 active site 271848015664 Restriction endonuclease; Region: Mrr_cat; cl00516 271848015665 Predicted methyltransferases [General function prediction only]; Region: COG0313 271848015666 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 271848015667 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848015668 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 271848015669 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848015670 Helix-turn-helix domains; Region: HTH; cl00088 271848015671 AsnC family; Region: AsnC_trans_reg; pfam01037 271848015672 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 271848015673 Cation efflux family; Region: Cation_efflux; cl00316 271848015674 H-NS histone family; Region: Histone_HNS; pfam00816 271848015675 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848015676 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271848015677 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848015678 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848015679 dimerization interface [polypeptide binding]; other site 271848015680 ligand binding site [chemical binding]; other site 271848015681 Nitronate monooxygenase; Region: NMO; pfam03060 271848015682 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 271848015683 FMN binding site [chemical binding]; other site 271848015684 substrate binding site [chemical binding]; other site 271848015685 putative catalytic residue [active] 271848015686 Dienelactone hydrolase family; Region: DLH; pfam01738 271848015687 amidase; Provisional; Region: PRK07869 271848015688 Amidase; Region: Amidase; cl11426 271848015689 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271848015690 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848015691 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 271848015692 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 271848015693 FAD binding site [chemical binding]; other site 271848015694 Membrane protein of unknown function; Region: DUF360; cl00850 271848015695 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 271848015696 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 271848015697 oligomerization interface [polypeptide binding]; other site 271848015698 active site 271848015699 NAD+ binding site [chemical binding]; other site 271848015700 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 271848015701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848015702 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271848015703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848015704 DNA binding residues [nucleotide binding] 271848015705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015706 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 271848015707 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 271848015708 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015709 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 271848015710 FHIPEP family; Region: FHIPEP; pfam00771 271848015711 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 271848015712 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271848015713 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 271848015714 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 271848015715 dimer interface [polypeptide binding]; other site 271848015716 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 271848015717 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 271848015718 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 271848015719 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 271848015720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848015721 active site 271848015722 phosphorylation site [posttranslational modification] 271848015723 intermolecular recognition site; other site 271848015724 dimerization interface [polypeptide binding]; other site 271848015725 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271848015726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848015727 active site 271848015728 phosphorylation site [posttranslational modification] 271848015729 intermolecular recognition site; other site 271848015730 dimerization interface [polypeptide binding]; other site 271848015731 CheB methylesterase; Region: CheB_methylest; pfam01339 271848015732 CheD chemotactic sensory transduction; Region: CheD; cl00810 271848015733 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 271848015734 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271848015735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848015736 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 271848015737 dimer interface [polypeptide binding]; other site 271848015738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848015739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848015740 dimer interface [polypeptide binding]; other site 271848015741 putative CheW interface [polypeptide binding]; other site 271848015742 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 271848015743 putative CheA interaction surface; other site 271848015744 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271848015745 putative binding surface; other site 271848015746 active site 271848015747 CheY binding; Region: CheY-binding; pfam09078 271848015748 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 271848015749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848015750 ATP binding site [chemical binding]; other site 271848015751 Mg2+ binding site [ion binding]; other site 271848015752 G-X-G motif; other site 271848015753 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 271848015754 Response regulator receiver domain; Region: Response_reg; pfam00072 271848015755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848015756 active site 271848015757 phosphorylation site [posttranslational modification] 271848015758 intermolecular recognition site; other site 271848015759 dimerization interface [polypeptide binding]; other site 271848015760 flagellar motor protein MotB; Validated; Region: motB; PRK09041 271848015761 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 271848015762 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848015763 ligand binding site [chemical binding]; other site 271848015764 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 271848015765 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 271848015766 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 271848015767 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 271848015768 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 271848015769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848015770 putative ADP-binding pocket [chemical binding]; other site 271848015771 H-NS histone family; Region: Histone_HNS; pfam00816 271848015772 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 271848015773 amphipathic channel; other site 271848015774 Asn-Pro-Ala signature motifs; other site 271848015775 putative hydrolase; Provisional; Region: PRK10976 271848015776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848015777 active site 271848015778 motif I; other site 271848015779 motif II; other site 271848015780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848015781 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 271848015782 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 271848015783 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 271848015784 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848015785 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848015786 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 271848015787 flagellin; Reviewed; Region: PRK08869 271848015788 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271848015789 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 271848015790 flagellar capping protein; Validated; Region: fliD; PRK08724 271848015791 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 271848015792 Flagellar protein FliT; Region: FliT; cl05125 271848015793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848015794 LysE type translocator; Region: LysE; cl00565 271848015795 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 271848015796 Phosphoesterase family; Region: Phosphoesterase; cl15450 271848015797 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 271848015798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 271848015799 TolB amino-terminal domain; Region: TolB_N; cl00639 271848015800 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 271848015801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 271848015802 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 271848015803 Cache domain; Region: Cache_1; pfam02743 271848015804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848015805 dimerization interface [polypeptide binding]; other site 271848015806 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848015807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848015808 dimer interface [polypeptide binding]; other site 271848015809 putative CheW interface [polypeptide binding]; other site 271848015810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848015811 TPR motif; other site 271848015812 binding surface 271848015813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848015814 binding surface 271848015815 TPR motif; other site 271848015816 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271848015817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848015818 TPR motif; other site 271848015819 binding surface 271848015820 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 271848015821 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 271848015822 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271848015823 inhibitor-cofactor binding pocket; inhibition site 271848015824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848015825 catalytic residue [active] 271848015826 WbqC-like protein family; Region: WbqC; pfam08889 271848015827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 271848015828 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 271848015829 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 271848015830 putative trimer interface [polypeptide binding]; other site 271848015831 putative CoA binding site [chemical binding]; other site 271848015832 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 271848015833 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 271848015834 trimer interface [polypeptide binding]; other site 271848015835 active site 271848015836 substrate binding site [chemical binding]; other site 271848015837 CoA binding site [chemical binding]; other site 271848015838 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848015839 FAD binding domain; Region: FAD_binding_4; pfam01565 271848015840 Berberine and berberine like; Region: BBE; pfam08031 271848015841 Chitin binding domain; Region: Chitin_bind_3; cl03871 271848015842 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848015843 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848015844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848015845 putative acetyltransferase; Provisional; Region: PRK03624 271848015846 Coenzyme A binding pocket [chemical binding]; other site 271848015847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848015848 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 271848015849 H-NS histone family; Region: Histone_HNS; pfam00816 271848015850 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 271848015851 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848015852 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848015853 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848015854 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848015855 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848015856 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 271848015857 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 271848015858 PAAR motif; Region: PAAR_motif; cl15808 271848015859 Integrase core domain; Region: rve; cl01316 271848015860 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 271848015861 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 271848015862 multiple promoter invertase; Provisional; Region: mpi; PRK13413 271848015863 catalytic residues [active] 271848015864 catalytic nucleophile [active] 271848015865 Presynaptic Site I dimer interface [polypeptide binding]; other site 271848015866 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 271848015867 Synaptic Flat tetramer interface [polypeptide binding]; other site 271848015868 Synaptic Site I dimer interface [polypeptide binding]; other site 271848015869 DNA binding site [nucleotide binding] 271848015870 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848015871 DNA-binding interface [nucleotide binding]; DNA binding site 271848015872 integrase; Provisional; Region: PRK09692 271848015873 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 271848015874 active site 271848015875 Int/Topo IB signature motif; other site 271848015876 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 271848015877 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 271848015878 trmE is a tRNA modification GTPase; Region: trmE; cd04164 271848015879 G1 box; other site 271848015880 GTP/Mg2+ binding site [chemical binding]; other site 271848015881 Switch I region; other site 271848015882 G2 box; other site 271848015883 Switch II region; other site 271848015884 G3 box; other site 271848015885 G4 box; other site 271848015886 G5 box; other site 271848015887 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 271848015888 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 271848015889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848015890 sequence-specific DNA binding site [nucleotide binding]; other site 271848015891 salt bridge; other site 271848015892 membrane protein insertase; Provisional; Region: PRK01318 271848015893 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 271848015894 Haemolytic domain; Region: Haemolytic; cl00506 271848015895 Ribonuclease P; Region: Ribonuclease_P; cl00457 271848015896 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 271848015897 DnaA N-terminal domain; Region: DnaA_N; pfam11638 271848015898 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 271848015899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848015900 Walker A motif; other site 271848015901 ATP binding site [chemical binding]; other site 271848015902 Walker B motif; other site 271848015903 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015904 arginine finger; other site 271848015905 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 271848015906 DnaA box-binding interface [nucleotide binding]; other site 271848015907 DNA polymerase III subunit beta; Validated; Region: PRK05643 271848015908 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 271848015909 putative DNA binding surface [nucleotide binding]; other site 271848015910 dimer interface [polypeptide binding]; other site 271848015911 beta-clamp/clamp loader binding surface; other site 271848015912 beta-clamp/translesion DNA polymerase binding surface; other site 271848015913 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 271848015914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848015915 ATP binding site [chemical binding]; other site 271848015916 Mg2+ binding site [ion binding]; other site 271848015917 G-X-G motif; other site 271848015918 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 271848015919 anchoring element; other site 271848015920 dimer interface [polypeptide binding]; other site 271848015921 ATP binding site [chemical binding]; other site 271848015922 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 271848015923 active site 271848015924 putative metal-binding site [ion binding]; other site 271848015925 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 271848015926 TIR domain; Region: TIR_2; cl15770 271848015927 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 271848015928 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848015929 MULE transposase domain; Region: MULE; pfam10551 271848015930 Helix-turn-helix domains; Region: HTH; cl00088 271848015931 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848015932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015933 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 271848015934 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848015935 NAD(P) binding site [chemical binding]; other site 271848015936 catalytic residues [active] 271848015937 transcriptional regulator EutR; Provisional; Region: PRK10130 271848015938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848015939 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848015940 thiamine pyrophosphate protein; Validated; Region: PRK08199 271848015941 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848015942 PYR/PP interface [polypeptide binding]; other site 271848015943 dimer interface [polypeptide binding]; other site 271848015944 TPP binding site [chemical binding]; other site 271848015945 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 271848015946 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 271848015947 TPP-binding site [chemical binding]; other site 271848015948 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 271848015949 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 271848015950 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 271848015951 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 271848015952 glycine dehydrogenase; Provisional; Region: PRK05367 271848015953 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 271848015954 tetramer interface [polypeptide binding]; other site 271848015955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848015956 catalytic residue [active] 271848015957 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 271848015958 tetramer interface [polypeptide binding]; other site 271848015959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848015960 catalytic residue [active] 271848015961 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 271848015962 lipoyl attachment site [posttranslational modification]; other site 271848015963 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 271848015964 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 271848015965 putative oxidoreductase; Provisional; Region: PRK11579 271848015966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848015967 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 271848015968 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 271848015969 active site 271848015970 catalytic triad [active] 271848015971 oxyanion hole [active] 271848015972 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 271848015973 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015974 Family description; Region: UvrD_C_2; cl15862 271848015975 Cytochrome c; Region: Cytochrom_C; cl11414 271848015976 Cytochrome c; Region: Cytochrom_C; cl11414 271848015977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848015978 non-specific DNA binding site [nucleotide binding]; other site 271848015979 salt bridge; other site 271848015980 sequence-specific DNA binding site [nucleotide binding]; other site 271848015981 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 271848015982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848015983 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848015984 type II secretion system protein D; Region: type_II_gspD; TIGR02517 271848015985 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848015986 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848015987 DDE superfamily endonuclease; Region: DDE_4; cl15789 271848015988 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848015989 active site 271848015990 DNA binding site [nucleotide binding] 271848015991 Int/Topo IB signature motif; other site 271848015992 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 271848015993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848015994 non-specific DNA binding site [nucleotide binding]; other site 271848015995 salt bridge; other site 271848015996 sequence-specific DNA binding site [nucleotide binding]; other site 271848015997 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848015998 active site 271848015999 DNA binding site [nucleotide binding] 271848016000 Int/Topo IB signature motif; other site 271848016001 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848016002 MULE transposase domain; Region: MULE; pfam10551 271848016003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848016004 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 271848016005 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 271848016006 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 271848016007 ethanolamine permease; Region: 2A0305; TIGR00908 271848016008 Spore germination protein; Region: Spore_permease; cl15802 271848016009 OpgC protein; Region: OpgC_C; cl00792 271848016010 Conserved TM helix; Region: TM_helix; pfam05552 271848016011 Conserved TM helix; Region: TM_helix; pfam05552 271848016012 Conserved TM helix; Region: TM_helix; pfam05552 271848016013 Double zinc ribbon; Region: DZR; pfam12773 271848016014 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271848016015 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 271848016016 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848016017 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 271848016018 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 271848016019 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 271848016020 DNA binding residues [nucleotide binding] 271848016021 dimer interface [polypeptide binding]; other site 271848016022 putative metal binding site [ion binding]; other site 271848016023 Helix-turn-helix domains; Region: HTH; cl00088 271848016024 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 271848016025 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 271848016026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848016027 substrate binding pocket [chemical binding]; other site 271848016028 membrane-bound complex binding site; other site 271848016029 hinge residues; other site 271848016030 putative aminotransferase; Provisional; Region: PRK12414 271848016031 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848016032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848016033 homodimer interface [polypeptide binding]; other site 271848016034 catalytic residue [active] 271848016035 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 271848016036 Helix-turn-helix domains; Region: HTH; cl00088 271848016037 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 271848016038 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848016039 active site 271848016040 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 271848016041 AMP-binding enzyme; Region: AMP-binding; cl15778 271848016042 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848016043 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848016044 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848016045 dimerization interface [polypeptide binding]; other site 271848016046 ligand binding site [chemical binding]; other site 271848016047 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 271848016048 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 271848016049 Proline dehydrogenase; Region: Pro_dh; cl03282 271848016050 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 271848016051 Glutamate binding site [chemical binding]; other site 271848016052 NAD binding site [chemical binding]; other site 271848016053 catalytic residues [active] 271848016054 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848016055 primosome assembly protein PriA; Validated; Region: PRK05580 271848016056 primosome assembly protein PriA; Validated; Region: PRK05580 271848016057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848016058 ATP binding site [chemical binding]; other site 271848016059 putative Mg++ binding site [ion binding]; other site 271848016060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 271848016061 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 271848016062 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 271848016063 substrate binding site [chemical binding]; other site 271848016064 active site 271848016065 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848016066 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848016067 substrate binding pocket [chemical binding]; other site 271848016068 membrane-bound complex binding site; other site 271848016069 hinge residues; other site 271848016070 AMP-binding domain protein; Validated; Region: PRK08315 271848016071 AMP-binding enzyme; Region: AMP-binding; cl15778 271848016072 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848016073 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 271848016074 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 271848016075 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 271848016076 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 271848016077 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271848016078 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 271848016079 alpha subunit interaction interface [polypeptide binding]; other site 271848016080 Walker A motif; other site 271848016081 ATP binding site [chemical binding]; other site 271848016082 Walker B motif; other site 271848016083 inhibitor binding site; inhibition site 271848016084 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271848016085 ATP synthase; Region: ATP-synt; cl00365 271848016086 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 271848016087 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 271848016088 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 271848016089 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 271848016090 beta subunit interaction interface [polypeptide binding]; other site 271848016091 Walker A motif; other site 271848016092 ATP binding site [chemical binding]; other site 271848016093 Walker B motif; other site 271848016094 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271848016095 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 271848016096 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 271848016097 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 271848016098 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 271848016099 ATP synthase subunit C; Region: ATP-synt_C; cl00466 271848016100 ATP synthase A chain; Region: ATP-synt_A; cl00413 271848016101 ATP synthase I chain; Region: ATP_synt_I; cl09170 271848016102 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 271848016103 transmembrane helices; other site 271848016104 ParB-like partition proteins; Region: parB_part; TIGR00180 271848016105 ParB-like nuclease domain; Region: ParBc; cl02129 271848016106 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271848016107 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848016108 P-loop; other site 271848016109 Magnesium ion binding site [ion binding]; other site 271848016110 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848016111 Magnesium ion binding site [ion binding]; other site 271848016112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848016113 S-adenosylmethionine binding site [chemical binding]; other site 271848016114 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 271848016115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848016116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848016117 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 271848016118 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848016119 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271848016120 Walker A/P-loop; other site 271848016121 ATP binding site [chemical binding]; other site 271848016122 Q-loop/lid; other site 271848016123 ABC transporter signature motif; other site 271848016124 Walker B; other site 271848016125 D-loop; other site 271848016126 H-loop/switch region; other site 271848016127 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848016128 TM-ABC transporter signature motif; other site 271848016129 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848016130 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 271848016131 Walker A/P-loop; other site 271848016132 ATP binding site [chemical binding]; other site 271848016133 Q-loop/lid; other site 271848016134 ABC transporter signature motif; other site 271848016135 Walker B; other site 271848016136 D-loop; other site 271848016137 H-loop/switch region; other site 271848016138 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848016139 TM-ABC transporter signature motif; other site 271848016140 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848016141 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 271848016142 putative ligand binding site [chemical binding]; other site 271848016143 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271848016144 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848016145 TM-ABC transporter signature motif; other site 271848016146 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848016147 TM-ABC transporter signature motif; other site 271848016148 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271848016149 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 271848016150 putative ligand binding site [chemical binding]; other site 271848016151 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848016152 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 271848016153 Walker A/P-loop; other site 271848016154 ATP binding site [chemical binding]; other site 271848016155 Q-loop/lid; other site 271848016156 ABC transporter signature motif; other site 271848016157 Walker B; other site 271848016158 D-loop; other site 271848016159 H-loop/switch region; other site 271848016160 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848016161 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 271848016162 Walker A/P-loop; other site 271848016163 ATP binding site [chemical binding]; other site 271848016164 Q-loop/lid; other site 271848016165 ABC transporter signature motif; other site 271848016166 Walker B; other site 271848016167 D-loop; other site 271848016168 H-loop/switch region; other site 271848016169 choline dehydrogenase; Validated; Region: PRK02106 271848016170 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848016171 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 271848016172 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848016173 tetrameric interface [polypeptide binding]; other site 271848016174 NAD binding site [chemical binding]; other site 271848016175 catalytic residues [active] 271848016176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848016177 Helix-turn-helix domains; Region: HTH; cl00088 271848016178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848016179 dimerization interface [polypeptide binding]; other site 271848016180 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 271848016181 putative active site [active] 271848016182 putative metal binding residues [ion binding]; other site 271848016183 signature motif; other site 271848016184 putative triphosphate binding site [ion binding]; other site 271848016185 dimer interface [polypeptide binding]; other site 271848016186 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848016187 Helix-turn-helix domains; Region: HTH; cl00088 271848016188 AsnC family; Region: AsnC_trans_reg; pfam01037 271848016189 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 271848016190 cofactor binding site; other site 271848016191 metal binding site [ion binding]; metal-binding site 271848016192 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 271848016193 aromatic arch; other site 271848016194 DCoH dimer interaction site [polypeptide binding]; other site 271848016195 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 271848016196 DCoH tetramer interaction site [polypeptide binding]; other site 271848016197 substrate binding site [chemical binding]; other site 271848016198 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 271848016199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848016200 active site 271848016201 phosphorylation site [posttranslational modification] 271848016202 intermolecular recognition site; other site 271848016203 dimerization interface [polypeptide binding]; other site 271848016204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848016205 DNA binding site [nucleotide binding] 271848016206 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271848016207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848016208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848016209 dimer interface [polypeptide binding]; other site 271848016210 phosphorylation site [posttranslational modification] 271848016211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848016212 ATP binding site [chemical binding]; other site 271848016213 Mg2+ binding site [ion binding]; other site 271848016214 G-X-G motif; other site 271848016215 SET domain; Region: SET; cl02566 271848016216 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 271848016217 active site 271848016218 FMN binding site [chemical binding]; other site 271848016219 substrate binding site [chemical binding]; other site 271848016220 homotetramer interface [polypeptide binding]; other site 271848016221 catalytic residue [active] 271848016222 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 271848016223 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 271848016224 catalytic triad [active] 271848016225 Transcriptional regulators [Transcription]; Region: MarR; COG1846 271848016226 Helix-turn-helix domains; Region: HTH; cl00088