-- dump date 20120504_140348 -- class Genbank::misc_feature -- table misc_feature_note -- id note 632348000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 632348000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 632348000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348000004 Walker A motif; other site 632348000005 ATP binding site [chemical binding]; other site 632348000006 Walker B motif; other site 632348000007 arginine finger; other site 632348000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 632348000009 DnaA box-binding interface [nucleotide binding]; other site 632348000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 632348000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 632348000012 putative DNA binding surface [nucleotide binding]; other site 632348000013 dimer interface [polypeptide binding]; other site 632348000014 beta-clamp/clamp loader binding surface; other site 632348000015 beta-clamp/translesion DNA polymerase binding surface; other site 632348000016 recombination protein F; Reviewed; Region: recF; PRK00064 632348000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348000018 Walker A/P-loop; other site 632348000019 ATP binding site [chemical binding]; other site 632348000020 Q-loop/lid; other site 632348000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348000022 ABC transporter signature motif; other site 632348000023 Walker B; other site 632348000024 D-loop; other site 632348000025 H-loop/switch region; other site 632348000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 632348000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000028 ATP binding site [chemical binding]; other site 632348000029 Mg2+ binding site [ion binding]; other site 632348000030 G-X-G motif; other site 632348000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 632348000032 anchoring element; other site 632348000033 dimer interface [polypeptide binding]; other site 632348000034 ATP binding site [chemical binding]; other site 632348000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 632348000036 active site 632348000037 putative metal-binding site [ion binding]; other site 632348000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 632348000039 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 632348000040 Fic/DOC family; Region: Fic; cl00960 632348000041 DNA gyrase subunit A; Validated; Region: PRK05560 632348000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 632348000043 CAP-like domain; other site 632348000044 active site 632348000045 primary dimer interface [polypeptide binding]; other site 632348000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632348000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632348000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632348000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632348000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632348000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632348000052 Beta propeller domain; Region: Beta_propel; pfam09826 632348000053 S-layer homology domain; Region: SLH; pfam00395 632348000054 S-layer homology domain; Region: SLH; pfam00395 632348000055 S-layer homology domain; Region: SLH; pfam00395 632348000056 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 632348000057 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000058 Interdomain contacts; other site 632348000059 Cytokine receptor motif; other site 632348000060 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632348000061 metal ion-dependent adhesion site (MIDAS); other site 632348000062 Bacterial SH3 domain; Region: SH3_3; cl02551 632348000063 RHS Repeat; Region: RHS_repeat; cl11982 632348000064 RHS Repeat; Region: RHS_repeat; cl11982 632348000065 RHS Repeat; Region: RHS_repeat; cl11982 632348000066 RHS Repeat; Region: RHS_repeat; cl11982 632348000067 RHS Repeat; Region: RHS_repeat; cl11982 632348000068 RHS Repeat; Region: RHS_repeat; cl11982 632348000069 RHS Repeat; Region: RHS_repeat; cl11982 632348000070 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 632348000071 RHS Repeat; Region: RHS_repeat; cl11982 632348000072 RHS Repeat; Region: RHS_repeat; cl11982 632348000073 RHS Repeat; Region: RHS_repeat; cl11982 632348000074 RHS Repeat; Region: RHS_repeat; cl11982 632348000075 RHS Repeat; Region: RHS_repeat; cl11982 632348000076 RHS Repeat; Region: RHS_repeat; cl11982 632348000077 RHS Repeat; Region: RHS_repeat; cl11982 632348000078 RHS Repeat; Region: RHS_repeat; cl11982 632348000079 RHS Repeat; Region: RHS_repeat; cl11982 632348000080 RHS Repeat; Region: RHS_repeat; cl11982 632348000081 RHS Repeat; Region: RHS_repeat; cl11982 632348000082 RHS Repeat; Region: RHS_repeat; cl11982 632348000083 RHS Repeat; Region: RHS_repeat; cl11982 632348000084 RHS Repeat; Region: RHS_repeat; cl11982 632348000085 RHS Repeat; Region: RHS_repeat; cl11982 632348000086 RHS Repeat; Region: RHS_repeat; cl11982 632348000087 RHS Repeat; Region: RHS_repeat; cl11982 632348000088 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 632348000089 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 632348000090 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632348000091 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 632348000092 Family description; Region: UvrD_C_2; cl15862 632348000093 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 632348000094 SOS regulatory protein LexA; Region: lexA; TIGR00498 632348000095 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632348000096 Catalytic site [active] 632348000097 peroxiredoxin; Provisional; Region: PRK13189 632348000098 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 632348000099 dimer interface [polypeptide binding]; other site 632348000100 decamer (pentamer of dimers) interface [polypeptide binding]; other site 632348000101 catalytic triad [active] 632348000102 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 632348000103 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 632348000104 Family description; Region: UvrD_C_2; cl15862 632348000105 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 632348000106 homodimer interface [polypeptide binding]; other site 632348000107 putative active site [active] 632348000108 catalytic site [active] 632348000109 PHF5-like protein; Region: PHF5; pfam03660 632348000110 hypothetical protein; Provisional; Region: PRK13795 632348000111 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632348000112 Active Sites [active] 632348000113 4Fe-4S binding domain; Region: Fer4; cl02805 632348000114 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 632348000115 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 632348000116 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632348000117 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632348000118 catalytic residue [active] 632348000119 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 632348000120 putative active site [active] 632348000121 catalytic site [active] 632348000122 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 632348000123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632348000124 ATP binding site [chemical binding]; other site 632348000125 putative Mg++ binding site [ion binding]; other site 632348000126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348000127 nucleotide binding region [chemical binding]; other site 632348000128 ATP-binding site [chemical binding]; other site 632348000129 Protein of unknown function DUF262; Region: DUF262; cl14890 632348000130 Protein of unknown function DUF262; Region: DUF262; cl14890 632348000131 KWG Leptospira; Region: KWG; pfam07656 632348000132 LemA family; Region: LemA; cl00742 632348000133 Repair protein; Region: Repair_PSII; cl01535 632348000134 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 632348000135 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 632348000136 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 632348000137 GDP-binding site [chemical binding]; other site 632348000138 ACT binding site; other site 632348000139 IMP binding site; other site 632348000140 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348000141 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348000142 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 632348000143 Walker A/P-loop; other site 632348000144 ATP binding site [chemical binding]; other site 632348000145 Q-loop/lid; other site 632348000146 ABC transporter signature motif; other site 632348000147 Walker B; other site 632348000148 D-loop; other site 632348000149 H-loop/switch region; other site 632348000150 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348000151 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348000152 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 632348000153 Walker A/P-loop; other site 632348000154 ATP binding site [chemical binding]; other site 632348000155 Q-loop/lid; other site 632348000156 ABC transporter signature motif; other site 632348000157 Walker B; other site 632348000158 D-loop; other site 632348000159 H-loop/switch region; other site 632348000160 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 632348000161 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632348000162 active site 632348000163 catalytic tetrad [active] 632348000164 Integral membrane protein DUF95; Region: DUF95; cl00572 632348000165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348000166 O-Antigen ligase; Region: Wzy_C; cl04850 632348000167 O-Antigen ligase; Region: Wzy_C; cl04850 632348000168 TPR repeat; Region: TPR_11; pfam13414 632348000169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632348000170 binding surface 632348000171 TPR motif; other site 632348000172 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632348000173 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348000174 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 632348000175 putative ADP-binding pocket [chemical binding]; other site 632348000176 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 632348000177 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632348000178 active site 632348000179 O-Antigen ligase; Region: Wzy_C; cl04850 632348000180 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 632348000181 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 632348000182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632348000183 active site 632348000184 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 632348000185 MatE; Region: MatE; cl10513 632348000186 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 632348000187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348000188 UDP-galactopyranose mutase; Region: GLF; pfam03275 632348000189 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 632348000190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348000191 Bacterial sugar transferase; Region: Bac_transf; cl00939 632348000192 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 632348000193 Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907 632348000194 ADP-ribose binding site [chemical binding]; other site 632348000195 CTP synthetase; Validated; Region: pyrG; PRK05380 632348000196 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 632348000197 Catalytic site [active] 632348000198 active site 632348000199 UTP binding site [chemical binding]; other site 632348000200 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 632348000201 active site 632348000202 putative oxyanion hole; other site 632348000203 catalytic triad [active] 632348000204 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632348000205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000206 active site 632348000207 phosphorylation site [posttranslational modification] 632348000208 intermolecular recognition site; other site 632348000209 dimerization interface [polypeptide binding]; other site 632348000210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632348000211 DNA binding site [nucleotide binding] 632348000212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 632348000213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348000214 dimerization interface [polypeptide binding]; other site 632348000215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 632348000216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632348000217 dimer interface [polypeptide binding]; other site 632348000218 phosphorylation site [posttranslational modification] 632348000219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000220 ATP binding site [chemical binding]; other site 632348000221 Mg2+ binding site [ion binding]; other site 632348000222 G-X-G motif; other site 632348000223 YycH protein; Region: YycI; cl02015 632348000224 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348000225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000226 dimer interface [polypeptide binding]; other site 632348000227 conserved gate region; other site 632348000228 ABC-ATPase subunit interface; other site 632348000229 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000231 dimer interface [polypeptide binding]; other site 632348000232 conserved gate region; other site 632348000233 putative PBP binding loops; other site 632348000234 ABC-ATPase subunit interface; other site 632348000235 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348000236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348000237 dimerization interface [polypeptide binding]; other site 632348000238 Histidine kinase; Region: His_kinase; pfam06580 632348000239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000240 ATP binding site [chemical binding]; other site 632348000241 Mg2+ binding site [ion binding]; other site 632348000242 G-X-G motif; other site 632348000243 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632348000244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000245 active site 632348000246 phosphorylation site [posttranslational modification] 632348000247 intermolecular recognition site; other site 632348000248 dimerization interface [polypeptide binding]; other site 632348000249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000251 S-layer homology domain; Region: SLH; pfam00395 632348000252 S-layer homology domain; Region: SLH; pfam00395 632348000253 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 632348000254 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 632348000255 active site 632348000256 catalytic residues [active] 632348000257 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348000258 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348000259 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632348000260 putative metal binding site [ion binding]; other site 632348000261 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348000262 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348000263 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348000264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632348000265 Histidine kinase; Region: His_kinase; pfam06580 632348000266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000267 ATP binding site [chemical binding]; other site 632348000268 Mg2+ binding site [ion binding]; other site 632348000269 G-X-G motif; other site 632348000270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000271 active site 632348000272 phosphorylation site [posttranslational modification] 632348000273 intermolecular recognition site; other site 632348000274 dimerization interface [polypeptide binding]; other site 632348000275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000276 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348000277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000278 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348000279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348000280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000281 dimer interface [polypeptide binding]; other site 632348000282 conserved gate region; other site 632348000283 putative PBP binding loops; other site 632348000284 ABC-ATPase subunit interface; other site 632348000285 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000287 dimer interface [polypeptide binding]; other site 632348000288 conserved gate region; other site 632348000289 putative PBP binding loops; other site 632348000290 ABC-ATPase subunit interface; other site 632348000291 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 632348000292 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000293 sugar binding site [chemical binding]; other site 632348000294 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 632348000295 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 632348000296 Ca binding site [ion binding]; other site 632348000297 Ca binding site (active) [ion binding]; other site 632348000298 ligand binding site [chemical binding]; other site 632348000299 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348000300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348000301 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 632348000302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000303 dimer interface [polypeptide binding]; other site 632348000304 conserved gate region; other site 632348000305 putative PBP binding loops; other site 632348000306 ABC-ATPase subunit interface; other site 632348000307 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000309 dimer interface [polypeptide binding]; other site 632348000310 conserved gate region; other site 632348000311 putative PBP binding loops; other site 632348000312 ABC-ATPase subunit interface; other site 632348000313 maltose phosphorylase; Provisional; Region: PRK13807 632348000314 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632348000315 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632348000316 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 632348000317 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 632348000318 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632348000319 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632348000320 beta-phosphoglucomutase; Region: bPGM; TIGR01990 632348000321 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 632348000322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348000323 motif II; other site 632348000324 S-layer homology domain; Region: SLH; pfam00395 632348000325 S-layer homology domain; Region: SLH; pfam00395 632348000326 S-layer homology domain; Region: SLH; pfam00395 632348000327 Fibronectin type III-like domain; Region: Fn3-like; cl15273 632348000328 Fibronectin type III-like domain; Region: Fn3-like; cl15273 632348000329 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 632348000330 putative ligand binding site [chemical binding]; other site 632348000331 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 632348000332 putative metal binding site [ion binding]; other site 632348000333 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 632348000334 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 632348000335 Right handed beta helix region; Region: Beta_helix; pfam13229 632348000336 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 632348000337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632348000338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632348000339 Histidine kinase; Region: His_kinase; pfam06580 632348000340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000341 ATP binding site [chemical binding]; other site 632348000342 Mg2+ binding site [ion binding]; other site 632348000343 G-X-G motif; other site 632348000344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000345 Response regulator receiver domain; Region: Response_reg; pfam00072 632348000346 active site 632348000347 phosphorylation site [posttranslational modification] 632348000348 intermolecular recognition site; other site 632348000349 dimerization interface [polypeptide binding]; other site 632348000350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000351 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348000352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000353 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348000354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348000355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000356 dimer interface [polypeptide binding]; other site 632348000357 conserved gate region; other site 632348000358 putative PBP binding loops; other site 632348000359 ABC-ATPase subunit interface; other site 632348000360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000362 dimer interface [polypeptide binding]; other site 632348000363 conserved gate region; other site 632348000364 putative PBP binding loops; other site 632348000365 ABC-ATPase subunit interface; other site 632348000366 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 632348000367 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 632348000368 dimer interface [polypeptide binding]; other site 632348000369 active site 632348000370 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 632348000371 dimer interface [polypeptide binding]; other site 632348000372 active site 632348000373 Response regulator receiver domain; Region: Response_reg; pfam00072 632348000374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000375 active site 632348000376 phosphorylation site [posttranslational modification] 632348000377 intermolecular recognition site; other site 632348000378 dimerization interface [polypeptide binding]; other site 632348000379 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348000380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000381 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348000382 dimerization interface [polypeptide binding]; other site 632348000383 Histidine kinase; Region: His_kinase; pfam06580 632348000384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000385 ATP binding site [chemical binding]; other site 632348000386 Mg2+ binding site [ion binding]; other site 632348000387 G-X-G motif; other site 632348000388 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632348000389 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 632348000390 active site 632348000391 substrate binding site [chemical binding]; other site 632348000392 metal binding site [ion binding]; metal-binding site 632348000393 Putative carbohydrate binding domain; Region: CBM_X; cl05621 632348000394 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 632348000395 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 632348000396 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 632348000397 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 632348000398 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 632348000399 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 632348000400 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 632348000401 putative active site [active] 632348000402 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 632348000403 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 632348000404 active site 632348000405 dimer interface [polypeptide binding]; other site 632348000406 Response regulator receiver domain; Region: Response_reg; pfam00072 632348000407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000408 active site 632348000409 phosphorylation site [posttranslational modification] 632348000410 intermolecular recognition site; other site 632348000411 dimerization interface [polypeptide binding]; other site 632348000412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348000413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632348000415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632348000416 Histidine kinase; Region: His_kinase; pfam06580 632348000417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000418 ATP binding site [chemical binding]; other site 632348000419 Mg2+ binding site [ion binding]; other site 632348000420 G-X-G motif; other site 632348000421 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348000422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348000423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000424 dimer interface [polypeptide binding]; other site 632348000425 conserved gate region; other site 632348000426 putative PBP binding loops; other site 632348000427 ABC-ATPase subunit interface; other site 632348000428 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000430 dimer interface [polypeptide binding]; other site 632348000431 conserved gate region; other site 632348000432 putative PBP binding loops; other site 632348000433 ABC-ATPase subunit interface; other site 632348000434 S-layer homology domain; Region: SLH; pfam00395 632348000435 S-layer homology domain; Region: SLH; pfam00395 632348000436 S-layer homology domain; Region: SLH; pfam00395 632348000437 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000438 Interdomain contacts; other site 632348000439 Cytokine receptor motif; other site 632348000440 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 632348000441 active site 632348000442 catalytic residues [active] 632348000443 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 632348000444 PKC phosphorylation site [posttranslational modification]; other site 632348000445 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000446 Interdomain contacts; other site 632348000447 Cytokine receptor motif; other site 632348000448 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000449 Interdomain contacts; other site 632348000450 Cytokine receptor motif; other site 632348000451 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 632348000452 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632348000453 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 632348000454 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000455 sugar binding site [chemical binding]; other site 632348000456 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632348000457 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000458 sugar binding site [chemical binding]; other site 632348000459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632348000460 DNA binding residues [nucleotide binding] 632348000461 dimerization interface [polypeptide binding]; other site 632348000462 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000463 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 632348000464 sugar binding site [chemical binding]; other site 632348000465 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000466 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 632348000467 sugar binding site [chemical binding]; other site 632348000468 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632348000469 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000470 Interdomain contacts; other site 632348000471 Cytokine receptor motif; other site 632348000472 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632348000473 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000474 sugar binding site [chemical binding]; other site 632348000475 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000476 sugar binding site [chemical binding]; other site 632348000477 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 632348000478 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000479 sugar binding site [chemical binding]; other site 632348000480 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 632348000481 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 632348000482 Ca binding site [ion binding]; other site 632348000483 ligand binding site I [chemical binding]; other site 632348000484 homodimer interface [polypeptide binding]; other site 632348000485 ligand binding site II [chemical binding]; other site 632348000486 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000487 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 632348000488 sugar binding site [chemical binding]; other site 632348000489 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000490 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 632348000491 sugar binding site [chemical binding]; other site 632348000492 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000493 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 632348000494 sugar binding site [chemical binding]; other site 632348000495 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 632348000496 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 632348000497 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348000498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348000500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348000501 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348000502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000503 ABC-ATPase subunit interface; other site 632348000504 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000506 dimer interface [polypeptide binding]; other site 632348000507 conserved gate region; other site 632348000508 putative PBP binding loops; other site 632348000509 ABC-ATPase subunit interface; other site 632348000510 beta-D-glucuronidase; Provisional; Region: PRK10150 632348000511 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 632348000512 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632348000513 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348000514 S-layer homology domain; Region: SLH; pfam00395 632348000515 S-layer homology domain; Region: SLH; pfam00395 632348000516 S-layer homology domain; Region: SLH; pfam00395 632348000517 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000518 Interdomain contacts; other site 632348000519 Cytokine receptor motif; other site 632348000520 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 632348000521 active site 632348000522 catalytic residues [active] 632348000523 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 632348000524 PKC phosphorylation site [posttranslational modification]; other site 632348000525 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000526 Interdomain contacts; other site 632348000527 Cytokine receptor motif; other site 632348000528 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000529 Interdomain contacts; other site 632348000530 Cytokine receptor motif; other site 632348000531 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 632348000532 PKC phosphorylation site [posttranslational modification]; other site 632348000533 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000534 Interdomain contacts; other site 632348000535 Cytokine receptor motif; other site 632348000536 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000537 Cytokine receptor motif; other site 632348000538 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632348000539 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348000540 sugar binding site [chemical binding]; other site 632348000541 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 632348000542 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 632348000543 active site 632348000544 Protein of unknown function DUF72; Region: DUF72; cl00777 632348000545 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 632348000546 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 632348000547 putative ligand binding site [chemical binding]; other site 632348000548 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632348000549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000550 active site 632348000551 phosphorylation site [posttranslational modification] 632348000552 intermolecular recognition site; other site 632348000553 dimerization interface [polypeptide binding]; other site 632348000554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632348000557 Histidine kinase; Region: His_kinase; pfam06580 632348000558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000559 ATP binding site [chemical binding]; other site 632348000560 Mg2+ binding site [ion binding]; other site 632348000561 G-X-G motif; other site 632348000562 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632348000563 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 632348000564 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 632348000565 putative ligand binding site [chemical binding]; other site 632348000566 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 632348000567 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 632348000568 Walker A/P-loop; other site 632348000569 ATP binding site [chemical binding]; other site 632348000570 Q-loop/lid; other site 632348000571 ABC transporter signature motif; other site 632348000572 Walker B; other site 632348000573 D-loop; other site 632348000574 H-loop/switch region; other site 632348000575 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 632348000576 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632348000577 TM-ABC transporter signature motif; other site 632348000578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348000579 dimerization interface [polypeptide binding]; other site 632348000580 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632348000581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348000582 dimer interface [polypeptide binding]; other site 632348000583 putative CheW interface [polypeptide binding]; other site 632348000584 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 632348000585 ABC-2 type transporter; Region: ABC2_membrane; cl11417 632348000586 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632348000587 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348000588 Walker A/P-loop; other site 632348000589 ATP binding site [chemical binding]; other site 632348000590 Q-loop/lid; other site 632348000591 ABC transporter signature motif; other site 632348000592 Walker B; other site 632348000593 D-loop; other site 632348000594 H-loop/switch region; other site 632348000595 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632348000596 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 632348000597 Walker A/P-loop; other site 632348000598 ATP binding site [chemical binding]; other site 632348000599 Q-loop/lid; other site 632348000600 ABC transporter signature motif; other site 632348000601 Walker B; other site 632348000602 D-loop; other site 632348000603 H-loop/switch region; other site 632348000604 Predicted transcriptional regulators [Transcription]; Region: COG1725 632348000605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348000606 DNA-binding site [nucleotide binding]; DNA binding site 632348000607 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 632348000608 nucleoside/Zn binding site; other site 632348000609 dimer interface [polypeptide binding]; other site 632348000610 catalytic motif [active] 632348000611 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632348000612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632348000613 Pectinesterase; Region: Pectinesterase; cl01911 632348000614 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632348000615 Helix-turn-helix domains; Region: HTH; cl00088 632348000616 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 632348000617 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 632348000618 D-xylulose kinase; Region: XylB; TIGR01312 632348000619 N- and C-terminal domain interface [polypeptide binding]; other site 632348000620 putative active site [active] 632348000621 catalytic site [active] 632348000622 metal binding site [ion binding]; metal-binding site 632348000623 putative xylulose binding site [chemical binding]; other site 632348000624 putative ATP binding site [chemical binding]; other site 632348000625 putative homodimer interface [polypeptide binding]; other site 632348000626 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 632348000627 hypothetical protein; Provisional; Region: PRK08185 632348000628 intersubunit interface [polypeptide binding]; other site 632348000629 active site 632348000630 zinc binding site [ion binding]; other site 632348000631 Na+ binding site [ion binding]; other site 632348000632 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632348000633 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632348000634 glyoxylate reductase; Reviewed; Region: PRK13243 632348000635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348000636 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632348000637 Helix-turn-helix domains; Region: HTH; cl00088 632348000638 Bacterial transcriptional regulator; Region: IclR; pfam01614 632348000639 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 632348000640 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 632348000641 active site 632348000642 intersubunit interface [polypeptide binding]; other site 632348000643 catalytic residue [active] 632348000644 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 632348000645 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632348000646 substrate binding site [chemical binding]; other site 632348000647 ATP binding site [chemical binding]; other site 632348000648 KduI/IolB family; Region: KduI; cl01508 632348000649 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 632348000650 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 632348000651 NADP binding site [chemical binding]; other site 632348000652 homodimer interface [polypeptide binding]; other site 632348000653 active site 632348000654 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 632348000655 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 632348000656 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 632348000657 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 632348000658 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 632348000659 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348000660 Interdomain contacts; other site 632348000661 Cytokine receptor motif; other site 632348000662 glycerate dehydrogenase; Provisional; Region: PRK06932 632348000663 Pectate lyase; Region: Pec_lyase_C; cl01593 632348000664 Pectinesterase; Region: Pectinesterase; cl01911 632348000665 MG2 domain; Region: A2M_N; pfam01835 632348000666 S-layer homology domain; Region: SLH; pfam00395 632348000667 S-layer homology domain; Region: SLH; pfam00395 632348000668 S-layer homology domain; Region: SLH; pfam00395 632348000669 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632348000670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348000671 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 632348000672 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 632348000673 active site 632348000674 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348000675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348000676 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000678 dimer interface [polypeptide binding]; other site 632348000679 conserved gate region; other site 632348000680 putative PBP binding loops; other site 632348000681 ABC-ATPase subunit interface; other site 632348000682 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000684 dimer interface [polypeptide binding]; other site 632348000685 conserved gate region; other site 632348000686 putative PBP binding loops; other site 632348000687 ABC-ATPase subunit interface; other site 632348000688 Response regulator receiver domain; Region: Response_reg; pfam00072 632348000689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000690 active site 632348000691 phosphorylation site [posttranslational modification] 632348000692 intermolecular recognition site; other site 632348000693 dimerization interface [polypeptide binding]; other site 632348000694 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348000695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000696 Histidine kinase; Region: His_kinase; pfam06580 632348000697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000698 ATP binding site [chemical binding]; other site 632348000699 Mg2+ binding site [ion binding]; other site 632348000700 G-X-G motif; other site 632348000701 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 632348000702 active site 632348000703 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 632348000704 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 632348000705 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632348000706 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348000707 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 632348000708 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 632348000709 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 632348000710 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 632348000711 ABC-2 type transporter; Region: ABC2_membrane; cl11417 632348000712 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 632348000713 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 632348000714 Walker A/P-loop; other site 632348000715 ATP binding site [chemical binding]; other site 632348000716 Q-loop/lid; other site 632348000717 ABC transporter signature motif; other site 632348000718 Walker B; other site 632348000719 D-loop; other site 632348000720 H-loop/switch region; other site 632348000721 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 632348000722 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 632348000723 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 632348000724 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 632348000725 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 632348000726 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632348000727 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 632348000728 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 632348000729 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 632348000730 Cupin domain; Region: Cupin_2; cl09118 632348000731 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 632348000732 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 632348000733 putative active site [active] 632348000734 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632348000735 4Fe-4S binding domain; Region: Fer4; cl02805 632348000736 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632348000737 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 632348000738 active site 632348000739 FMN binding site [chemical binding]; other site 632348000740 substrate binding site [chemical binding]; other site 632348000741 3Fe-4S cluster binding site [ion binding]; other site 632348000742 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 632348000743 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 632348000744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632348000745 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 632348000746 putative subunit interface; other site 632348000747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348000748 Zn2+ binding site [ion binding]; other site 632348000749 Mg2+ binding site [ion binding]; other site 632348000750 L-lactate permease; Region: Lactate_perm; cl00701 632348000751 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632348000752 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 632348000753 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 632348000754 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 632348000755 Fibronectin type III-like domain; Region: Fn3-like; cl15273 632348000756 Transposase domain (DUF772); Region: DUF772; cl15789 632348000757 Transposase domain (DUF772); Region: DUF772; cl15789 632348000758 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 632348000759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348000760 FeS/SAM binding site; other site 632348000761 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 632348000762 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348000763 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348000764 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348000765 Walker A/P-loop; other site 632348000766 ATP binding site [chemical binding]; other site 632348000767 Q-loop/lid; other site 632348000768 ABC transporter signature motif; other site 632348000769 Walker B; other site 632348000770 D-loop; other site 632348000771 H-loop/switch region; other site 632348000772 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348000773 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348000774 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 632348000775 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348000776 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632348000777 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 632348000778 FtsX-like permease family; Region: FtsX; cl15850 632348000779 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348000780 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 632348000781 Walker A/P-loop; other site 632348000782 ATP binding site [chemical binding]; other site 632348000783 Q-loop/lid; other site 632348000784 ABC transporter signature motif; other site 632348000785 Walker B; other site 632348000786 D-loop; other site 632348000787 H-loop/switch region; other site 632348000788 S-layer homology domain; Region: SLH; pfam00395 632348000789 S-layer homology domain; Region: SLH; pfam00395 632348000790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348000791 DNA-binding site [nucleotide binding]; DNA binding site 632348000792 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632348000793 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 632348000794 Walker A/P-loop; other site 632348000795 ATP binding site [chemical binding]; other site 632348000796 Q-loop/lid; other site 632348000797 ABC transporter signature motif; other site 632348000798 Walker B; other site 632348000799 D-loop; other site 632348000800 H-loop/switch region; other site 632348000801 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632348000802 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348000803 Walker A/P-loop; other site 632348000804 ATP binding site [chemical binding]; other site 632348000805 Q-loop/lid; other site 632348000806 ABC transporter signature motif; other site 632348000807 Walker B; other site 632348000808 D-loop; other site 632348000809 H-loop/switch region; other site 632348000810 ABC-2 type transporter; Region: ABC2_membrane; cl11417 632348000811 TraX protein; Region: TraX; cl05434 632348000812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632348000813 Probable transposase; Region: OrfB_IS605; pfam01385 632348000814 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632348000815 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632348000816 active site 632348000817 NTP binding site [chemical binding]; other site 632348000818 metal binding triad [ion binding]; metal-binding site 632348000819 antibiotic binding site [chemical binding]; other site 632348000820 Protein of unknown function DUF86; Region: DUF86; cl01031 632348000821 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 632348000822 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 632348000823 FMN binding site [chemical binding]; other site 632348000824 active site 632348000825 catalytic residues [active] 632348000826 substrate binding site [chemical binding]; other site 632348000827 S-layer homology domain; Region: SLH; pfam00395 632348000828 S-layer homology domain; Region: SLH; pfam00395 632348000829 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 632348000830 C-terminal peptidase (prc); Region: prc; TIGR00225 632348000831 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 632348000832 protein binding site [polypeptide binding]; other site 632348000833 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 632348000834 Catalytic dyad [active] 632348000835 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 632348000836 rod shape-determining protein Mbl; Provisional; Region: PRK13928 632348000837 Cell division protein FtsA; Region: FtsA; cl11496 632348000838 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 632348000839 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 632348000840 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 632348000841 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 632348000842 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 632348000843 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 632348000844 Rod binding protein; Region: Rod-binding; cl01626 632348000845 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632348000846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348000847 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632348000848 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632348000849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348000850 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 632348000851 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 632348000852 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632348000853 active site 632348000854 catalytic tetrad [active] 632348000855 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632348000856 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632348000857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348000858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000859 dimer interface [polypeptide binding]; other site 632348000860 conserved gate region; other site 632348000861 putative PBP binding loops; other site 632348000862 ABC-ATPase subunit interface; other site 632348000863 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348000864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348000865 dimer interface [polypeptide binding]; other site 632348000866 conserved gate region; other site 632348000867 ABC-ATPase subunit interface; other site 632348000868 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348000869 Helix-turn-helix domain; Region: HTH_18; pfam12833 632348000870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348000871 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632348000872 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 632348000873 TPP-binding site [chemical binding]; other site 632348000874 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 632348000875 PYR/PP interface [polypeptide binding]; other site 632348000876 dimer interface [polypeptide binding]; other site 632348000877 TPP binding site [chemical binding]; other site 632348000878 Membrane transport protein; Region: Mem_trans; cl09117 632348000879 H+ Antiporter protein; Region: 2A0121; TIGR00900 632348000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348000881 putative substrate translocation pore; other site 632348000882 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 632348000883 active site 632348000884 catalytic triad [active] 632348000885 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 632348000886 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 632348000887 active site 632348000888 substrate binding site [chemical binding]; other site 632348000889 metal binding site [ion binding]; metal-binding site 632348000890 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 632348000891 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 632348000892 glutaminase active site [active] 632348000893 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 632348000894 dimer interface [polypeptide binding]; other site 632348000895 active site 632348000896 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 632348000897 dimer interface [polypeptide binding]; other site 632348000898 active site 632348000899 Helix-turn-helix domains; Region: HTH; cl00088 632348000900 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 632348000901 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 632348000902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632348000903 non-specific DNA binding site [nucleotide binding]; other site 632348000904 salt bridge; other site 632348000905 sequence-specific DNA binding site [nucleotide binding]; other site 632348000906 DNA polymerase IV; Reviewed; Region: PRK03103 632348000907 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 632348000908 active site 632348000909 DNA binding site [nucleotide binding] 632348000910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632348000911 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632348000912 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632348000913 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632348000914 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348000915 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348000916 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632348000917 carboxyltransferase (CT) interaction site; other site 632348000918 biotinylation site [posttranslational modification]; other site 632348000919 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348000920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632348000921 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632348000922 FtsX-like permease family; Region: FtsX; cl15850 632348000923 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 632348000924 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 632348000925 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 632348000926 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 632348000927 Walker A/P-loop; other site 632348000928 ATP binding site [chemical binding]; other site 632348000929 Q-loop/lid; other site 632348000930 ABC transporter signature motif; other site 632348000931 Walker B; other site 632348000932 D-loop; other site 632348000933 H-loop/switch region; other site 632348000934 Nitrogen regulatory protein P-II; Region: P-II; cl00412 632348000935 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 632348000936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348000937 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 632348000938 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 632348000939 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 632348000940 Histidine kinase; Region: His_kinase; pfam06580 632348000941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000942 ATP binding site [chemical binding]; other site 632348000943 Mg2+ binding site [ion binding]; other site 632348000944 G-X-G motif; other site 632348000945 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 632348000946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000947 active site 632348000948 phosphorylation site [posttranslational modification] 632348000949 intermolecular recognition site; other site 632348000950 dimerization interface [polypeptide binding]; other site 632348000951 LytTr DNA-binding domain; Region: LytTR; cl04498 632348000952 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 632348000953 Carbon starvation protein CstA; Region: CstA; pfam02554 632348000954 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 632348000955 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 632348000956 active site 632348000957 substrate binding site [chemical binding]; other site 632348000958 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 632348000959 FMN binding site [chemical binding]; other site 632348000960 putative catalytic residues [active] 632348000961 Iron permease FTR1 family; Region: FTR1; cl00475 632348000962 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 632348000963 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 632348000964 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 632348000965 Ligand Binding Site [chemical binding]; other site 632348000966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 632348000967 Transposase; Region: DDE_Tnp_ISL3; pfam01610 632348000968 YcfA-like protein; Region: YcfA; cl00752 632348000969 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 632348000970 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 632348000971 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632348000972 trehalose synthase; Region: treS_nterm; TIGR02456 632348000973 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 632348000974 Ca binding site [ion binding]; other site 632348000975 active site 632348000976 catalytic site [active] 632348000977 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 632348000978 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 632348000979 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 632348000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348000981 S-adenosylmethionine binding site [chemical binding]; other site 632348000982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632348000983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348000984 active site 632348000985 phosphorylation site [posttranslational modification] 632348000986 intermolecular recognition site; other site 632348000987 dimerization interface [polypeptide binding]; other site 632348000988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632348000989 DNA binding site [nucleotide binding] 632348000990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632348000991 dimer interface [polypeptide binding]; other site 632348000992 phosphorylation site [posttranslational modification] 632348000993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348000994 ATP binding site [chemical binding]; other site 632348000995 Mg2+ binding site [ion binding]; other site 632348000996 G-X-G motif; other site 632348000997 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632348000998 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632348000999 FtsX-like permease family; Region: FtsX; cl15850 632348001000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348001001 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 632348001002 Walker A/P-loop; other site 632348001003 ATP binding site [chemical binding]; other site 632348001004 Q-loop/lid; other site 632348001005 ABC transporter signature motif; other site 632348001006 Walker B; other site 632348001007 D-loop; other site 632348001008 H-loop/switch region; other site 632348001009 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 632348001010 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348001011 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632348001012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001013 Nucleoside recognition; Region: Gate; cl00486 632348001014 Nucleoside recognition; Region: Gate; cl00486 632348001015 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 632348001016 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 632348001017 B12 binding site [chemical binding]; other site 632348001018 cobalt ligand [ion binding]; other site 632348001019 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 632348001020 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 632348001021 intersubunit interface [polypeptide binding]; other site 632348001022 active site 632348001023 Zn2+ binding site [ion binding]; other site 632348001024 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 632348001025 maltodextrin glucosidase; Provisional; Region: PRK10785 632348001026 homodimer interface [polypeptide binding]; other site 632348001027 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 632348001028 active site 632348001029 homodimer interface [polypeptide binding]; other site 632348001030 catalytic site [active] 632348001031 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 632348001032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001033 dimer interface [polypeptide binding]; other site 632348001034 conserved gate region; other site 632348001035 putative PBP binding loops; other site 632348001036 ABC-ATPase subunit interface; other site 632348001037 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 632348001038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001039 dimer interface [polypeptide binding]; other site 632348001040 conserved gate region; other site 632348001041 putative PBP binding loops; other site 632348001042 ABC-ATPase subunit interface; other site 632348001043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632348001044 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 632348001045 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348001046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632348001047 DNA binding site [nucleotide binding] 632348001048 domain linker motif; other site 632348001049 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 632348001050 putative dimerization interface [polypeptide binding]; other site 632348001051 putative ligand binding site [chemical binding]; other site 632348001052 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 632348001053 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348001054 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 632348001055 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 632348001056 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 632348001057 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 632348001058 Beta-galactosidase, domain 2; Region: BetaGal_dom2; cl11086 632348001059 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 632348001060 active site 632348001061 MoxR-like ATPases [General function prediction only]; Region: COG0714 632348001062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348001063 Walker A motif; other site 632348001064 ATP binding site [chemical binding]; other site 632348001065 Walker B motif; other site 632348001066 arginine finger; other site 632348001067 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 632348001068 dimer interface [polypeptide binding]; other site 632348001069 substrate binding site [chemical binding]; other site 632348001070 metal binding site [ion binding]; metal-binding site 632348001071 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 632348001072 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 632348001073 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 632348001074 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348001075 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632348001076 DNA binding site [nucleotide binding] 632348001077 domain linker motif; other site 632348001078 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632348001079 Domain of unknown function (DUF377); Region: DUF377; pfam04041 632348001080 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 632348001081 active site 632348001082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348001083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348001084 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348001085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001086 dimer interface [polypeptide binding]; other site 632348001087 conserved gate region; other site 632348001088 putative PBP binding loops; other site 632348001089 ABC-ATPase subunit interface; other site 632348001090 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348001091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001092 dimer interface [polypeptide binding]; other site 632348001093 conserved gate region; other site 632348001094 ABC-ATPase subunit interface; other site 632348001095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632348001096 Histidine kinase; Region: His_kinase; pfam06580 632348001097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348001098 ATP binding site [chemical binding]; other site 632348001099 Mg2+ binding site [ion binding]; other site 632348001100 G-X-G motif; other site 632348001101 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632348001102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348001103 active site 632348001104 phosphorylation site [posttranslational modification] 632348001105 intermolecular recognition site; other site 632348001106 dimerization interface [polypeptide binding]; other site 632348001107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348001108 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 632348001109 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 632348001110 THF binding site; other site 632348001111 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 632348001112 substrate binding site [chemical binding]; other site 632348001113 THF binding site; other site 632348001114 zinc-binding site [ion binding]; other site 632348001115 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632348001116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348001117 S-adenosylmethionine binding site [chemical binding]; other site 632348001118 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 632348001119 YokU-like protein; Region: YokU; cl15819 632348001120 RRXRR protein; Region: RRXRR; pfam14239 632348001121 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 632348001122 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 632348001123 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 632348001124 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632348001125 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632348001126 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632348001127 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 632348001128 putative peptidoglycan binding site; other site 632348001129 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 632348001130 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632348001131 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632348001132 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632348001133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348001134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632348001135 DNA binding site [nucleotide binding] 632348001136 domain linker motif; other site 632348001137 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 632348001138 dimerization interface [polypeptide binding]; other site 632348001139 ligand binding site [chemical binding]; other site 632348001140 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348001141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348001142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348001143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001144 dimer interface [polypeptide binding]; other site 632348001145 conserved gate region; other site 632348001146 putative PBP binding loops; other site 632348001147 ABC-ATPase subunit interface; other site 632348001148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348001149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001150 dimer interface [polypeptide binding]; other site 632348001151 conserved gate region; other site 632348001152 putative PBP binding loops; other site 632348001153 ABC-ATPase subunit interface; other site 632348001154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348001155 dimerization interface [polypeptide binding]; other site 632348001156 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632348001157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348001158 dimer interface [polypeptide binding]; other site 632348001159 putative CheW interface [polypeptide binding]; other site 632348001160 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348001161 dimer interface [polypeptide binding]; other site 632348001162 putative CheW interface [polypeptide binding]; other site 632348001163 Cache domain; Region: Cache_1; pfam02743 632348001164 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632348001165 oxaloacetate decarboxylase; Provisional; Region: PRK12331 632348001166 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 632348001167 active site 632348001168 catalytic residues [active] 632348001169 metal binding site [ion binding]; metal-binding site 632348001170 homodimer binding site [polypeptide binding]; other site 632348001171 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 632348001172 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 632348001173 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632348001174 carboxyltransferase (CT) interaction site; other site 632348001175 biotinylation site [posttranslational modification]; other site 632348001176 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 632348001177 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348001178 dimerization interface [polypeptide binding]; other site 632348001179 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632348001180 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348001181 dimer interface [polypeptide binding]; other site 632348001182 putative CheW interface [polypeptide binding]; other site 632348001183 S-layer homology domain; Region: SLH; pfam00395 632348001184 Bacterial Ig-like domain; Region: Big_5; cl01012 632348001185 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 632348001186 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 632348001187 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632348001188 E3 interaction surface; other site 632348001189 lipoyl attachment site [posttranslational modification]; other site 632348001190 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348001191 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348001192 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348001193 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348001194 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 632348001195 Walker A/P-loop; other site 632348001196 ATP binding site [chemical binding]; other site 632348001197 Q-loop/lid; other site 632348001198 ABC transporter signature motif; other site 632348001199 Walker B; other site 632348001200 D-loop; other site 632348001201 H-loop/switch region; other site 632348001202 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632348001203 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632348001204 FtsX-like permease family; Region: FtsX; cl15850 632348001205 S-layer homology domain; Region: SLH; pfam00395 632348001206 S-layer homology domain; Region: SLH; pfam00395 632348001207 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632348001208 putative active site [active] 632348001209 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 632348001210 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 632348001211 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632348001212 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 632348001213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001214 FOG: CBS domain [General function prediction only]; Region: COG0517 632348001215 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 632348001216 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 632348001217 Walker A motif; other site 632348001218 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 632348001219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 632348001220 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 632348001221 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632348001222 metal-binding site [ion binding] 632348001223 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632348001224 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632348001225 metal-binding site [ion binding] 632348001226 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632348001227 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 632348001228 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632348001229 metal-binding site [ion binding] 632348001230 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 632348001231 Protein of unknown function DUF86; Region: DUF86; cl01031 632348001232 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632348001233 active site 632348001234 NTP binding site [chemical binding]; other site 632348001235 metal binding triad [ion binding]; metal-binding site 632348001236 antibiotic binding site [chemical binding]; other site 632348001237 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 632348001238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348001239 FeS/SAM binding site; other site 632348001240 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 632348001241 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 632348001242 Chain length determinant protein; Region: Wzz; cl15801 632348001243 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 632348001244 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 632348001245 Nucleotide binding site [chemical binding]; other site 632348001246 DTAP/Switch II; other site 632348001247 Switch I; other site 632348001248 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 632348001249 S-layer homology domain; Region: SLH; pfam00395 632348001250 S-layer homology domain; Region: SLH; pfam00395 632348001251 S-layer homology domain; Region: SLH; pfam00395 632348001252 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 632348001253 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 632348001254 NADP-binding site; other site 632348001255 homotetramer interface [polypeptide binding]; other site 632348001256 substrate binding site [chemical binding]; other site 632348001257 homodimer interface [polypeptide binding]; other site 632348001258 active site 632348001259 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 632348001260 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 632348001261 NADP binding site [chemical binding]; other site 632348001262 active site 632348001263 putative substrate binding site [chemical binding]; other site 632348001264 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 632348001265 Bacterial sugar transferase; Region: Bac_transf; cl00939 632348001266 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 632348001267 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 632348001268 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632348001269 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 632348001270 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 632348001271 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 632348001272 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 632348001273 active site 632348001274 NAD binding site [chemical binding]; other site 632348001275 metal binding site [ion binding]; metal-binding site 632348001276 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 632348001277 active site 632348001278 metal-binding site 632348001279 VanZ like family; Region: VanZ; cl01971 632348001280 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632348001281 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 632348001282 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 632348001283 Walker A/P-loop; other site 632348001284 ATP binding site [chemical binding]; other site 632348001285 Q-loop/lid; other site 632348001286 ABC transporter signature motif; other site 632348001287 Walker B; other site 632348001288 D-loop; other site 632348001289 H-loop/switch region; other site 632348001290 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 632348001291 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632348001292 Helix-turn-helix domains; Region: HTH; cl00088 632348001293 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 632348001294 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 632348001295 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 632348001296 Walker A/P-loop; other site 632348001297 ATP binding site [chemical binding]; other site 632348001298 Q-loop/lid; other site 632348001299 ABC transporter signature motif; other site 632348001300 Walker B; other site 632348001301 D-loop; other site 632348001302 H-loop/switch region; other site 632348001303 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 632348001304 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632348001305 TM-ABC transporter signature motif; other site 632348001306 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 632348001307 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632348001308 ligand binding site [chemical binding]; other site 632348001309 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632348001310 hypothetical protein; Provisional; Region: PRK09956 632348001311 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632348001312 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 632348001313 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 632348001314 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632348001315 active site 632348001316 HIGH motif; other site 632348001317 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632348001318 active site 632348001319 KMSKS motif; other site 632348001320 serine O-acetyltransferase; Region: cysE; TIGR01172 632348001321 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 632348001322 trimer interface [polypeptide binding]; other site 632348001323 active site 632348001324 substrate binding site [chemical binding]; other site 632348001325 CoA binding site [chemical binding]; other site 632348001326 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 632348001327 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 632348001328 active site 632348001329 HIGH motif; other site 632348001330 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 632348001331 KMSKS motif; other site 632348001332 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 632348001333 tRNA binding surface [nucleotide binding]; other site 632348001334 anticodon binding site; other site 632348001335 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 632348001336 Transposase IS200 like; Region: Y1_Tnp; cl00848 632348001337 Protein of unknown function (DUF421); Region: DUF421; cl00990 632348001338 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 632348001339 putative active site pocket [active] 632348001340 dimerization interface [polypeptide binding]; other site 632348001341 putative catalytic residue [active] 632348001342 Helix-turn-helix domains; Region: HTH; cl00088 632348001343 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 632348001344 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 632348001345 putative active site [active] 632348001346 metal binding site [ion binding]; metal-binding site 632348001347 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348001348 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348001349 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348001350 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 632348001351 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 632348001352 putative ligand binding site [chemical binding]; other site 632348001353 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 632348001354 Ca binding site [ion binding]; other site 632348001355 carbohydrate binding site [chemical binding]; other site 632348001356 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 632348001357 S-layer homology domain; Region: SLH; pfam00395 632348001358 S-layer homology domain; Region: SLH; pfam00395 632348001359 Amino acid permease; Region: AA_permease_2; pfam13520 632348001360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 632348001361 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 632348001362 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 632348001363 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632348001364 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632348001365 metal binding site [ion binding]; metal-binding site 632348001366 active site 632348001367 I-site; other site 632348001368 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632348001369 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348001370 dimer interface [polypeptide binding]; other site 632348001371 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 632348001372 putative CheW interface [polypeptide binding]; other site 632348001373 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632348001374 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348001375 dimer interface [polypeptide binding]; other site 632348001376 putative CheW interface [polypeptide binding]; other site 632348001377 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632348001378 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632348001379 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632348001380 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 632348001381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348001382 active site 632348001383 phosphorylation site [posttranslational modification] 632348001384 intermolecular recognition site; other site 632348001385 dimerization interface [polypeptide binding]; other site 632348001386 CheB methylesterase; Region: CheB_methylest; pfam01339 632348001387 Response regulator receiver domain; Region: Response_reg; pfam00072 632348001388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348001389 active site 632348001390 phosphorylation site [posttranslational modification] 632348001391 intermolecular recognition site; other site 632348001392 dimerization interface [polypeptide binding]; other site 632348001393 Chemotaxis phosphatase CheX; Region: CheX; cl15816 632348001394 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 632348001395 Chemotaxis phosphatase CheX; Region: CheX; cl15816 632348001396 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 632348001397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001398 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 632348001399 putative binding surface; other site 632348001400 active site 632348001401 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 632348001402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632348001403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348001404 ATP binding site [chemical binding]; other site 632348001405 G-X-G motif; other site 632348001406 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632348001407 ribulokinase; Provisional; Region: PRK04123 632348001408 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 632348001409 putative N- and C-terminal domain interface [polypeptide binding]; other site 632348001410 putative active site [active] 632348001411 putative MgATP binding site [chemical binding]; other site 632348001412 catalytic site [active] 632348001413 metal binding site [ion binding]; metal-binding site 632348001414 carbohydrate binding site [chemical binding]; other site 632348001415 homodimer interface [polypeptide binding]; other site 632348001416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348001417 DNA-binding site [nucleotide binding]; DNA binding site 632348001418 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348001419 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 632348001420 putative dimerization interface [polypeptide binding]; other site 632348001421 putative ligand binding site [chemical binding]; other site 632348001422 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 632348001423 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 632348001424 intersubunit interface [polypeptide binding]; other site 632348001425 active site 632348001426 Zn2+ binding site [ion binding]; other site 632348001427 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 632348001428 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 632348001429 active site 632348001430 catalytic residues [active] 632348001431 metal binding site [ion binding]; metal-binding site 632348001432 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 632348001433 4Fe-4S binding domain; Region: Fer4; cl02805 632348001434 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 632348001435 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 632348001436 glutamine binding [chemical binding]; other site 632348001437 catalytic triad [active] 632348001438 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 632348001439 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 632348001440 chorismate binding enzyme; Region: Chorismate_bind; cl10555 632348001441 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 632348001442 substrate-cofactor binding pocket; other site 632348001443 homodimer interface [polypeptide binding]; other site 632348001444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348001445 catalytic residue [active] 632348001446 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 632348001447 4Fe-4S binding domain; Region: Fer4_5; pfam12801 632348001448 FMN-binding domain; Region: FMN_bind; cl01081 632348001449 ApbE family; Region: ApbE; cl00643 632348001450 Helix-turn-helix domains; Region: HTH; cl00088 632348001451 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632348001452 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348001453 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_3; cd09321 632348001454 gating phenylalanine in ion channel; other site 632348001455 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 632348001456 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 632348001457 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632348001458 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 632348001459 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 632348001460 Potassium binding sites [ion binding]; other site 632348001461 Cesium cation binding sites [ion binding]; other site 632348001462 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 632348001463 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 632348001464 substrate-cofactor binding pocket; other site 632348001465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348001466 catalytic residue [active] 632348001467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001468 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632348001469 NAD(P) binding site [chemical binding]; other site 632348001470 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348001471 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632348001472 DNA binding site [nucleotide binding] 632348001473 domain linker motif; other site 632348001474 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 632348001475 putative dimerization interface [polypeptide binding]; other site 632348001476 putative ligand binding site [chemical binding]; other site 632348001477 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632348001478 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348001479 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 632348001480 Predicted methyltransferases [General function prediction only]; Region: COG1568 632348001481 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 632348001482 Uncharacterized conserved protein [Function unknown]; Region: COG0585 632348001483 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 632348001484 active site 632348001485 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 632348001486 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632348001487 active site 632348001488 NTP binding site [chemical binding]; other site 632348001489 metal binding triad [ion binding]; metal-binding site 632348001490 antibiotic binding site [chemical binding]; other site 632348001491 Protein of unknown function DUF86; Region: DUF86; cl01031 632348001492 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 632348001493 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 632348001494 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348001495 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 632348001496 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632348001497 ABC-ATPase subunit interface; other site 632348001498 dimer interface [polypeptide binding]; other site 632348001499 putative PBP binding regions; other site 632348001500 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 632348001501 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 632348001502 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632348001503 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 632348001504 intersubunit interface [polypeptide binding]; other site 632348001505 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632348001506 metal binding site 2 [ion binding]; metal-binding site 632348001507 putative DNA binding helix; other site 632348001508 metal binding site 1 [ion binding]; metal-binding site 632348001509 dimer interface [polypeptide binding]; other site 632348001510 structural Zn2+ binding site [ion binding]; other site 632348001511 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632348001512 dimerization interface [polypeptide binding]; other site 632348001513 putative DNA binding site [nucleotide binding]; other site 632348001514 putative Zn2+ binding site [ion binding]; other site 632348001515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348001516 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632348001517 FeS/SAM binding site; other site 632348001518 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 632348001519 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 632348001520 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 632348001521 hypothetical protein; Reviewed; Region: PRK09588 632348001522 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 632348001523 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 632348001524 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 632348001525 DNA topoisomerase I; Validated; Region: PRK05582 632348001526 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 632348001527 active site 632348001528 interdomain interaction site; other site 632348001529 putative metal-binding site [ion binding]; other site 632348001530 nucleotide binding site [chemical binding]; other site 632348001531 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 632348001532 domain I; other site 632348001533 DNA binding groove [nucleotide binding] 632348001534 phosphate binding site [ion binding]; other site 632348001535 domain II; other site 632348001536 domain III; other site 632348001537 nucleotide binding site [chemical binding]; other site 632348001538 catalytic site [active] 632348001539 domain IV; other site 632348001540 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 632348001541 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 632348001542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001543 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 632348001544 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 632348001545 active site 632348001546 HslU subunit interaction site [polypeptide binding]; other site 632348001547 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 632348001548 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348001549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348001550 Walker A motif; other site 632348001551 ATP binding site [chemical binding]; other site 632348001552 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348001553 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 632348001554 transcriptional repressor CodY; Validated; Region: PRK04158 632348001555 CodY GAF-like domain; Region: CodY; pfam06018 632348001556 Helix-turn-helix domains; Region: HTH; cl00088 632348001557 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 632348001558 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 632348001559 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 632348001560 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 632348001561 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 632348001562 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 632348001563 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 632348001564 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 632348001565 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 632348001566 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 632348001567 FliG C-terminal domain; Region: FliG_C; pfam01706 632348001568 Plant ATP synthase F0; Region: YMF19; cl07975 632348001569 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 632348001570 Flagellar assembly protein FliH; Region: FliH; pfam02108 632348001571 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 632348001572 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 632348001573 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 632348001574 Walker A motif/ATP binding site; other site 632348001575 Walker B motif; other site 632348001576 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 632348001577 MgtE intracellular N domain; Region: MgtE_N; cl15244 632348001578 MgtE intracellular N domain; Region: MgtE_N; cl15244 632348001579 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 632348001580 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 632348001581 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 632348001582 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 632348001583 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 632348001584 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 632348001585 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 632348001586 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 632348001587 Flagellar protein (FlbD); Region: FlbD; cl00683 632348001588 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 632348001589 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 632348001590 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 632348001591 flagellar motor switch protein; Validated; Region: PRK08119 632348001592 Chemotaxis phosphatase CheX; Region: CheX; cl15816 632348001593 Chemotaxis phosphatase CheX; Region: CheX; cl15816 632348001594 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 632348001595 Response regulator receiver domain; Region: Response_reg; pfam00072 632348001596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348001597 active site 632348001598 phosphorylation site [posttranslational modification] 632348001599 intermolecular recognition site; other site 632348001600 dimerization interface [polypeptide binding]; other site 632348001601 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 632348001602 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 632348001603 FliP family; Region: FliP; cl00593 632348001604 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 632348001605 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 632348001606 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 632348001607 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 632348001608 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 632348001609 FHIPEP family; Region: FHIPEP; pfam00771 632348001610 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 632348001611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348001612 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 632348001613 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 632348001614 P-loop; other site 632348001615 Flagellar protein YcgR; Region: YcgR_2; pfam12945 632348001616 PilZ domain; Region: PilZ; cl01260 632348001617 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 632348001618 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 632348001619 putative binding surface; other site 632348001620 active site 632348001621 P2 response regulator binding domain; Region: P2; pfam07194 632348001622 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 632348001623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348001624 ATP binding site [chemical binding]; other site 632348001625 Mg2+ binding site [ion binding]; other site 632348001626 G-X-G motif; other site 632348001627 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 632348001628 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632348001629 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 632348001630 Chemotaxis phosphatase CheX; Region: CheX; cl15816 632348001631 Chemotaxis phosphatase CheX; Region: CheX; cl15816 632348001632 Chemotaxis phosphatase CheX; Region: CheX; cl15816 632348001633 CheD chemotactic sensory transduction; Region: CheD; cl00810 632348001634 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 632348001635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348001636 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632348001637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348001638 DNA binding residues [nucleotide binding] 632348001639 Protein of unknown function (DUF342); Region: DUF342; pfam03961 632348001640 Cupin domain; Region: Cupin_2; cl09118 632348001641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348001642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348001643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348001644 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 632348001645 oligomerisation interface [polypeptide binding]; other site 632348001646 mobile loop; other site 632348001647 roof hairpin; other site 632348001648 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 632348001649 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 632348001650 ring oligomerisation interface [polypeptide binding]; other site 632348001651 ATP/Mg binding site [chemical binding]; other site 632348001652 stacking interactions; other site 632348001653 hinge regions; other site 632348001654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348001655 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 632348001656 active site 632348001657 motif I; other site 632348001658 motif II; other site 632348001659 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 632348001660 Uncharacterized conserved protein [Function unknown]; Region: COG2006 632348001661 Domain of unknown function (DUF362); Region: DUF362; pfam04015 632348001662 4Fe-4S binding domain; Region: Fer4; cl02805 632348001663 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 632348001664 4Fe-4S binding domain; Region: Fer4; cl02805 632348001665 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 632348001666 Chemotaxis phosphatase CheX; Region: CheX; cl15816 632348001667 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 632348001668 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 632348001669 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 632348001670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348001671 FeS/SAM binding site; other site 632348001672 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 632348001673 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 632348001674 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 632348001675 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 632348001676 homodimer interface [polypeptide binding]; other site 632348001677 oligonucleotide binding site [chemical binding]; other site 632348001678 elongation factor P; Validated; Region: PRK00529 632348001679 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 632348001680 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 632348001681 RNA binding site [nucleotide binding]; other site 632348001682 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 632348001683 RNA binding site [nucleotide binding]; other site 632348001684 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 632348001685 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632348001686 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632348001687 catalytic residue [active] 632348001688 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 632348001689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001690 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 632348001691 putative L-serine binding site [chemical binding]; other site 632348001692 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 632348001693 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 632348001694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348001695 motif II; other site 632348001696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348001697 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 632348001698 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632348001699 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 632348001700 putative substrate binding site [chemical binding]; other site 632348001701 putative ATP binding site [chemical binding]; other site 632348001702 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 632348001703 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 632348001704 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 632348001705 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 632348001706 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 632348001707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 632348001708 ribonuclease R; Region: RNase_R; TIGR02063 632348001709 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632348001710 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632348001711 RNB domain; Region: RNB; pfam00773 632348001712 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 632348001713 RNA binding site [nucleotide binding]; other site 632348001714 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 632348001715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348001716 Walker A motif; other site 632348001717 ATP binding site [chemical binding]; other site 632348001718 Walker B motif; other site 632348001719 arginine finger; other site 632348001720 Uncharacterized conserved protein [Function unknown]; Region: COG2006 632348001721 Domain of unknown function (DUF362); Region: DUF362; pfam04015 632348001722 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 632348001723 30S subunit binding site; other site 632348001724 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 632348001725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348001726 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 632348001727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348001728 nucleotide binding region [chemical binding]; other site 632348001729 ATP-binding site [chemical binding]; other site 632348001730 peptide chain release factor 2; Validated; Region: prfB; PRK00578 632348001731 RF-1 domain; Region: RF-1; cl02875 632348001732 RF-1 domain; Region: RF-1; cl02875 632348001733 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632348001734 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 632348001735 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 632348001736 substrate binding site [chemical binding]; other site 632348001737 ligand binding site [chemical binding]; other site 632348001738 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 632348001739 substrate binding site [chemical binding]; other site 632348001740 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 632348001741 tartrate dehydrogenase; Provisional; Region: PRK08194 632348001742 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 632348001743 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632348001744 active site 632348001745 catalytic tetrad [active] 632348001746 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632348001747 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 632348001748 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 632348001749 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632348001750 dimer interface [polypeptide binding]; other site 632348001751 ssDNA binding site [nucleotide binding]; other site 632348001752 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632348001753 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 632348001754 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 632348001755 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348001756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001757 dimer interface [polypeptide binding]; other site 632348001758 conserved gate region; other site 632348001759 ABC-ATPase subunit interface; other site 632348001760 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348001761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001762 dimer interface [polypeptide binding]; other site 632348001763 conserved gate region; other site 632348001764 putative PBP binding loops; other site 632348001765 ABC-ATPase subunit interface; other site 632348001766 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348001767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348001768 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632348001769 Walker A motif; other site 632348001770 ATP binding site [chemical binding]; other site 632348001771 Walker B motif; other site 632348001772 arginine finger; other site 632348001773 Integrase core domain; Region: rve; cl01316 632348001774 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 632348001775 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 632348001776 phosphate binding site [ion binding]; other site 632348001777 4Fe-4S binding domain; Region: Fer4; cl02805 632348001778 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 632348001779 4Fe-4S binding domain; Region: Fer4; cl02805 632348001780 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 632348001781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001782 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632348001783 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 632348001784 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632348001785 catalytic Zn binding site [ion binding]; other site 632348001786 structural Zn binding site [ion binding]; other site 632348001787 tetramer interface [polypeptide binding]; other site 632348001788 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632348001789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001790 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 632348001791 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 632348001792 metal binding site [ion binding]; metal-binding site 632348001793 active site 632348001794 S-layer homology domain; Region: SLH; pfam00395 632348001795 S-layer homology domain; Region: SLH; pfam00395 632348001796 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348001797 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348001798 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348001799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348001800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001801 putative PBP binding loops; other site 632348001802 dimer interface [polypeptide binding]; other site 632348001803 ABC-ATPase subunit interface; other site 632348001804 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348001805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001806 dimer interface [polypeptide binding]; other site 632348001807 conserved gate region; other site 632348001808 putative PBP binding loops; other site 632348001809 ABC-ATPase subunit interface; other site 632348001810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632348001811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348001812 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 632348001813 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 632348001814 active site 632348001815 catalytic triad [active] 632348001816 oxyanion hole [active] 632348001817 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348001818 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632348001819 DNA binding site [nucleotide binding] 632348001820 domain linker motif; other site 632348001821 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632348001822 dimerization interface [polypeptide binding]; other site 632348001823 ligand binding site [chemical binding]; other site 632348001824 hypothetical protein; Provisional; Region: PRK08185 632348001825 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 632348001826 intersubunit interface [polypeptide binding]; other site 632348001827 active site 632348001828 zinc binding site [ion binding]; other site 632348001829 Na+ binding site [ion binding]; other site 632348001830 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 632348001831 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 632348001832 putative NAD(P) binding site [chemical binding]; other site 632348001833 catalytic Zn binding site [ion binding]; other site 632348001834 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 632348001835 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 632348001836 putative active site [active] 632348001837 metal binding site [ion binding]; metal-binding site 632348001838 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 632348001839 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 632348001840 N- and C-terminal domain interface [polypeptide binding]; other site 632348001841 putative active site [active] 632348001842 catalytic site [active] 632348001843 metal binding site [ion binding]; metal-binding site 632348001844 putative xylulose binding site [chemical binding]; other site 632348001845 putative ATP binding site [chemical binding]; other site 632348001846 putative homodimer interface [polypeptide binding]; other site 632348001847 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 632348001848 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632348001849 Helix-turn-helix domains; Region: HTH; cl00088 632348001850 Integrase core domain; Region: rve; cl01316 632348001851 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 632348001852 magnesium-transporting ATPase; Provisional; Region: PRK15122 632348001853 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632348001854 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 632348001855 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 632348001856 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 632348001857 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 632348001858 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348001859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348001860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348001861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348001862 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348001863 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 632348001864 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 632348001865 active site 632348001866 homotrimer interface [polypeptide binding]; other site 632348001867 catalytic site [active] 632348001868 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 632348001869 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348001870 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632348001871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 632348001872 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 632348001873 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 632348001874 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 632348001875 alpha-galactosidase; Provisional; Region: PRK15076 632348001876 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 632348001877 NAD binding site [chemical binding]; other site 632348001878 sugar binding site [chemical binding]; other site 632348001879 divalent metal binding site [ion binding]; other site 632348001880 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 632348001881 dimer interface [polypeptide binding]; other site 632348001882 putative alpha-glucosidase; Provisional; Region: PRK10658 632348001883 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 632348001884 putative active site [active] 632348001885 putative catalytic site [active] 632348001886 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348001887 Carboxylesterase family; Region: COesterase; pfam00135 632348001888 substrate binding pocket [chemical binding]; other site 632348001889 catalytic triad [active] 632348001890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 632348001891 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632348001892 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 632348001893 inhibitor binding site; inhibition site 632348001894 catalytic Zn binding site [ion binding]; other site 632348001895 structural Zn binding site [ion binding]; other site 632348001896 NADP binding site [chemical binding]; other site 632348001897 tetramer interface [polypeptide binding]; other site 632348001898 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 632348001899 substrate binding site [chemical binding]; other site 632348001900 Mn binding site [ion binding]; other site 632348001901 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 632348001902 Glycerate kinase family; Region: Gly_kinase; cl00841 632348001903 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 632348001904 23S rRNA interface [nucleotide binding]; other site 632348001905 L3 interface [polypeptide binding]; other site 632348001906 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 632348001907 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 632348001908 Nitrogen regulatory protein P-II; Region: P-II; cl00412 632348001909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348001910 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632348001911 DNA repair protein RadA; Provisional; Region: PRK11823 632348001912 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 632348001913 Walker A motif/ATP binding site; other site 632348001914 ATP binding site [chemical binding]; other site 632348001915 Walker B motif; other site 632348001916 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 632348001917 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 632348001918 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 632348001919 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 632348001920 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 632348001921 Uncharacterized conserved protein [Function unknown]; Region: COG1284 632348001922 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 632348001923 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 632348001924 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 632348001925 TPP-binding site [chemical binding]; other site 632348001926 dimer interface [polypeptide binding]; other site 632348001927 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 632348001928 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632348001929 PYR/PP interface [polypeptide binding]; other site 632348001930 dimer interface [polypeptide binding]; other site 632348001931 TPP binding site [chemical binding]; other site 632348001932 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632348001933 Cupin domain; Region: Cupin_2; cl09118 632348001934 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 632348001935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348001936 putative alpha-glucosidase; Provisional; Region: PRK10658 632348001937 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 632348001938 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 632348001939 active site 632348001940 homotrimer interface [polypeptide binding]; other site 632348001941 catalytic site [active] 632348001942 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 632348001943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348001944 dimerization interface [polypeptide binding]; other site 632348001945 Histidine kinase; Region: His_kinase; pfam06580 632348001946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348001947 ATP binding site [chemical binding]; other site 632348001948 Mg2+ binding site [ion binding]; other site 632348001949 G-X-G motif; other site 632348001950 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632348001951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348001952 active site 632348001953 phosphorylation site [posttranslational modification] 632348001954 intermolecular recognition site; other site 632348001955 dimerization interface [polypeptide binding]; other site 632348001956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348001957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348001958 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348001959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001960 dimer interface [polypeptide binding]; other site 632348001961 conserved gate region; other site 632348001962 ABC-ATPase subunit interface; other site 632348001963 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348001964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348001965 dimer interface [polypeptide binding]; other site 632348001966 conserved gate region; other site 632348001967 ABC-ATPase subunit interface; other site 632348001968 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348001969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348001970 MgtC family; Region: MgtC; pfam02308 632348001971 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 632348001972 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 632348001973 homodimer interface [polypeptide binding]; other site 632348001974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348001975 catalytic residue [active] 632348001976 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 632348001977 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 632348001978 dimerization interface [polypeptide binding]; other site 632348001979 active site 632348001980 metal binding site [ion binding]; metal-binding site 632348001981 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 632348001982 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 632348001983 DNA replication protein DnaC; Validated; Region: PRK06835 632348001984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348001985 Walker A motif; other site 632348001986 ATP binding site [chemical binding]; other site 632348001987 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 632348001988 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 632348001989 Thymidylate synthase complementing protein; Region: Thy1; cl03630 632348001990 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 632348001991 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 632348001992 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 632348001993 YacP-like NYN domain; Region: NYN_YacP; cl01491 632348001994 RNA polymerase factor sigma-70; Validated; Region: PRK08295 632348001995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348001996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 632348001997 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632348001998 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 632348001999 active site 632348002000 substrate binding site [chemical binding]; other site 632348002001 metal binding site [ion binding]; metal-binding site 632348002002 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 632348002003 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 632348002004 ATP-grasp domain; Region: ATP-grasp_4; cl03087 632348002005 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 632348002006 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 632348002007 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 632348002008 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 632348002009 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 632348002010 active site 632348002011 HIGH motif; other site 632348002012 KMSK motif region; other site 632348002013 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 632348002014 tRNA binding surface [nucleotide binding]; other site 632348002015 anticodon binding site; other site 632348002016 AMP-binding enzyme; Region: AMP-binding; cl15778 632348002017 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632348002018 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 632348002019 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632348002020 active site 632348002021 FMN binding site [chemical binding]; other site 632348002022 substrate binding site [chemical binding]; other site 632348002023 3Fe-4S cluster binding site [ion binding]; other site 632348002024 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 632348002025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348002026 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348002027 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348002029 dimer interface [polypeptide binding]; other site 632348002030 conserved gate region; other site 632348002031 ABC-ATPase subunit interface; other site 632348002032 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348002033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348002034 dimer interface [polypeptide binding]; other site 632348002035 ABC-ATPase subunit interface; other site 632348002036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348002037 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 632348002038 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 632348002039 Int/Topo IB signature motif; other site 632348002040 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632348002041 DNA-binding interface [nucleotide binding]; DNA binding site 632348002042 PrgI family protein; Region: PrgI; pfam12666 632348002043 AAA-like domain; Region: AAA_10; pfam12846 632348002044 Domain of unknown function DUF87; Region: DUF87; pfam01935 632348002045 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 632348002046 Predicted ATPase [General function prediction only]; Region: COG5293 632348002047 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 632348002048 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632348002049 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 632348002050 IHF dimer interface [polypeptide binding]; other site 632348002051 IHF - DNA interface [nucleotide binding]; other site 632348002052 plasmid segregation protein ParM; Provisional; Region: PRK13917 632348002053 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 632348002054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348002055 Walker A motif; other site 632348002056 ATP binding site [chemical binding]; other site 632348002057 Walker B motif; other site 632348002058 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 632348002059 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632348002060 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632348002061 RNA binding site [nucleotide binding]; other site 632348002062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348002063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632348002064 Probable transposase; Region: OrfB_IS605; pfam01385 632348002065 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632348002066 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 632348002067 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 632348002068 RNA/DNA hybrid binding site [nucleotide binding]; other site 632348002069 active site 632348002070 REJ domain; Region: REJ; pfam02010 632348002071 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 632348002072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348002073 Walker A motif; other site 632348002074 ATP binding site [chemical binding]; other site 632348002075 Walker B motif; other site 632348002076 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 632348002077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348002078 S-adenosylmethionine binding site [chemical binding]; other site 632348002079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632348002080 active site 632348002081 SAF domain; Region: SAF; cl00555 632348002082 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632348002083 dimer interface [polypeptide binding]; other site 632348002084 ssDNA binding site [nucleotide binding]; other site 632348002085 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632348002086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348002087 Zn2+ binding site [ion binding]; other site 632348002088 Mg2+ binding site [ion binding]; other site 632348002089 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 632348002090 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 632348002091 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632348002092 catalytic residue [active] 632348002093 Peptidase family M23; Region: Peptidase_M23; pfam01551 632348002094 Helix-turn-helix domains; Region: HTH; cl00088 632348002095 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 632348002096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632348002097 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 632348002098 active site 632348002099 DNA binding site [nucleotide binding] 632348002100 Int/Topo IB signature motif; other site 632348002101 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632348002102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632348002103 Probable transposase; Region: OrfB_IS605; pfam01385 632348002104 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632348002105 RecT family; Region: RecT; cl04285 632348002106 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 632348002107 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 632348002108 MPN+ (JAMM) motif; other site 632348002109 Zinc-binding site [ion binding]; other site 632348002110 Uncharacterized protein conserved in bacteria (DUF2321); Region: DUF2321; pfam10083 632348002111 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632348002112 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 632348002113 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 632348002114 NAD binding site [chemical binding]; other site 632348002115 sugar binding site [chemical binding]; other site 632348002116 divalent metal binding site [ion binding]; other site 632348002117 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 632348002118 dimer interface [polypeptide binding]; other site 632348002119 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632348002120 putative active site [active] 632348002121 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 632348002122 Ferritin-like domain; Region: Ferritin; pfam00210 632348002123 ferroxidase diiron center [ion binding]; other site 632348002124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348002125 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 632348002126 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 632348002127 oligomerization interface [polypeptide binding]; other site 632348002128 active site 632348002129 metal binding site [ion binding]; metal-binding site 632348002130 pantoate--beta-alanine ligase; Region: panC; TIGR00018 632348002131 Pantoate-beta-alanine ligase; Region: PanC; cd00560 632348002132 active site 632348002133 ATP-binding site [chemical binding]; other site 632348002134 pantoate-binding site; other site 632348002135 HXXH motif; other site 632348002136 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 632348002137 tetramerization interface [polypeptide binding]; other site 632348002138 active site 632348002139 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 632348002140 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 632348002141 Coat F domain; Region: Coat_F; cl15836 632348002142 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 632348002143 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 632348002144 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 632348002145 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632348002146 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632348002147 DNA interaction; other site 632348002148 Metal-binding active site; metal-binding site 632348002149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348002150 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632348002151 FeS/SAM binding site; other site 632348002152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348002153 FeS/SAM binding site; other site 632348002154 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 632348002155 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 632348002156 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 632348002157 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 632348002158 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348002159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348002160 Walker A/P-loop; other site 632348002161 ATP binding site [chemical binding]; other site 632348002162 Q-loop/lid; other site 632348002163 ABC transporter signature motif; other site 632348002164 Walker B; other site 632348002165 D-loop; other site 632348002166 H-loop/switch region; other site 632348002167 aspartate kinase; Reviewed; Region: PRK06635 632348002168 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 632348002169 putative catalytic residues [active] 632348002170 putative nucleotide binding site [chemical binding]; other site 632348002171 putative aspartate binding site [chemical binding]; other site 632348002172 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 632348002173 putative allosteric regulatory site; other site 632348002174 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 632348002175 putative allosteric regulatory residue; other site 632348002176 homoserine kinase; Provisional; Region: PRK01212 632348002177 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632348002178 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632348002179 homoserine dehydrogenase; Provisional; Region: PRK06349 632348002180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348002181 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 632348002182 hypothetical protein; Provisional; Region: PRK04435 632348002183 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 632348002184 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 632348002185 Spore germination protein; Region: Spore_permease; cl15802 632348002186 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 632348002187 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 632348002188 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 632348002189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348002190 active site 632348002191 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 632348002192 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 632348002193 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 632348002194 synthetase active site [active] 632348002195 NTP binding site [chemical binding]; other site 632348002196 metal binding site [ion binding]; metal-binding site 632348002197 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 632348002198 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 632348002199 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 632348002200 putative active site [active] 632348002201 dimerization interface [polypeptide binding]; other site 632348002202 putative tRNAtyr binding site [nucleotide binding]; other site 632348002203 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348002204 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 632348002205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348002206 FeS/SAM binding site; other site 632348002207 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632348002208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348002209 FeS/SAM binding site; other site 632348002210 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 632348002211 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 632348002212 active site 632348002213 homodimer interface [polypeptide binding]; other site 632348002214 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 632348002215 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348002216 Interdomain contacts; other site 632348002217 Cytokine receptor motif; other site 632348002218 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632348002219 Interdomain contacts; other site 632348002220 Cytokine receptor motif; other site 632348002221 S-layer homology domain; Region: SLH; pfam00395 632348002222 S-layer homology domain; Region: SLH; pfam00395 632348002223 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632348002224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632348002225 substrate binding pocket [chemical binding]; other site 632348002226 membrane-bound complex binding site; other site 632348002227 hinge residues; other site 632348002228 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632348002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348002230 dimer interface [polypeptide binding]; other site 632348002231 conserved gate region; other site 632348002232 putative PBP binding loops; other site 632348002233 ABC-ATPase subunit interface; other site 632348002234 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632348002235 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 632348002236 Walker A/P-loop; other site 632348002237 ATP binding site [chemical binding]; other site 632348002238 Q-loop/lid; other site 632348002239 ABC transporter signature motif; other site 632348002240 Walker B; other site 632348002241 D-loop; other site 632348002242 H-loop/switch region; other site 632348002243 EamA-like transporter family; Region: EamA; cl01037 632348002244 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 632348002245 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348002246 Beta-Casp domain; Region: Beta-Casp; cl12567 632348002247 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632348002248 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 632348002249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 632348002250 Transposase; Region: DDE_Tnp_ISL3; pfam01610 632348002251 2-ketoisovalerate ferredoxin oxidoreductase subunit delta; Reviewed; Region: vorD; PRK09623 632348002252 4Fe-4S binding domain; Region: Fer4; cl02805 632348002253 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 632348002254 ADP/pyrophosphate binding site [chemical binding]; other site 632348002255 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 632348002256 Membrane transport protein; Region: Mem_trans; cl09117 632348002257 Low molecular weight phosphatase family; Region: LMWPc; cd00115 632348002258 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 632348002259 active site 632348002260 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632348002261 dimerization interface [polypeptide binding]; other site 632348002262 putative DNA binding site [nucleotide binding]; other site 632348002263 putative Zn2+ binding site [ion binding]; other site 632348002264 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632348002265 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 632348002266 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 632348002267 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632348002268 sporulation sigma factor SigK; Reviewed; Region: PRK05803 632348002269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348002270 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 632348002271 CHC2 zinc finger; Region: zf-CHC2; cl15369 632348002272 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 632348002273 active site 632348002274 metal binding site [ion binding]; metal-binding site 632348002275 interdomain interaction site; other site 632348002276 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348002277 Walker A motif; other site 632348002278 ATP binding site [chemical binding]; other site 632348002279 Walker B motif; other site 632348002280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632348002281 non-specific DNA binding site [nucleotide binding]; other site 632348002282 salt bridge; other site 632348002283 sequence-specific DNA binding site [nucleotide binding]; other site 632348002284 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632348002285 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632348002286 active site 632348002287 DNA binding site [nucleotide binding] 632348002288 Int/Topo IB signature motif; other site 632348002289 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348002290 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 632348002291 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 632348002292 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 632348002293 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 632348002294 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 632348002295 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 632348002296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348002297 FeS/SAM binding site; other site 632348002298 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 632348002299 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 632348002300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348002301 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 632348002302 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 632348002303 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 632348002304 Competence protein; Region: Competence; cl00471 632348002305 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348002306 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 632348002307 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 632348002308 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 632348002309 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 632348002310 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 632348002311 NAD binding site [chemical binding]; other site 632348002312 dimer interface [polypeptide binding]; other site 632348002313 substrate binding site [chemical binding]; other site 632348002314 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632348002315 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632348002316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348002317 dimer interface [polypeptide binding]; other site 632348002318 conserved gate region; other site 632348002319 putative PBP binding loops; other site 632348002320 ABC-ATPase subunit interface; other site 632348002321 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 632348002322 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 632348002323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348002324 dimer interface [polypeptide binding]; other site 632348002325 conserved gate region; other site 632348002326 putative PBP binding loops; other site 632348002327 ABC-ATPase subunit interface; other site 632348002328 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 632348002329 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 632348002330 Walker A/P-loop; other site 632348002331 ATP binding site [chemical binding]; other site 632348002332 Q-loop/lid; other site 632348002333 ABC transporter signature motif; other site 632348002334 Walker B; other site 632348002335 D-loop; other site 632348002336 H-loop/switch region; other site 632348002337 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632348002338 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 632348002339 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 632348002340 Walker A/P-loop; other site 632348002341 ATP binding site [chemical binding]; other site 632348002342 Q-loop/lid; other site 632348002343 ABC transporter signature motif; other site 632348002344 Walker B; other site 632348002345 D-loop; other site 632348002346 H-loop/switch region; other site 632348002347 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632348002348 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 632348002349 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 632348002350 peptide binding site [polypeptide binding]; other site 632348002351 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632348002352 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 632348002353 metal binding site [ion binding]; metal-binding site 632348002354 dimer interface [polypeptide binding]; other site 632348002355 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632348002356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348002357 DNA-binding site [nucleotide binding]; DNA binding site 632348002358 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632348002359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348002360 homodimer interface [polypeptide binding]; other site 632348002361 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 632348002362 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 632348002363 active site 632348002364 multimer interface [polypeptide binding]; other site 632348002365 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 632348002366 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 632348002367 predicted active site [active] 632348002368 catalytic triad [active] 632348002369 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 632348002370 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 632348002371 putative carbohydrate kinase; Provisional; Region: PRK10565 632348002372 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 632348002373 putative substrate binding site [chemical binding]; other site 632348002374 putative ATP binding site [chemical binding]; other site 632348002375 alanine racemase; Reviewed; Region: alr; PRK00053 632348002376 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 632348002377 active site 632348002378 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632348002379 dimer interface [polypeptide binding]; other site 632348002380 substrate binding site [chemical binding]; other site 632348002381 catalytic residues [active] 632348002382 PemK-like protein; Region: PemK; cl00995 632348002383 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 632348002384 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632348002385 catalytic residues [active] 632348002386 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348002387 lipoyl-biotinyl attachment site [posttranslational modification]; other site 632348002388 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632348002389 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632348002390 intersubunit interface [polypeptide binding]; other site 632348002391 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632348002392 ABC-ATPase subunit interface; other site 632348002393 dimer interface [polypeptide binding]; other site 632348002394 putative PBP binding regions; other site 632348002395 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632348002396 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632348002397 Walker A/P-loop; other site 632348002398 ATP binding site [chemical binding]; other site 632348002399 Q-loop/lid; other site 632348002400 ABC transporter signature motif; other site 632348002401 Walker B; other site 632348002402 D-loop; other site 632348002403 H-loop/switch region; other site 632348002404 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 632348002405 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 632348002406 Bacterial SH3 domain; Region: SH3_3; cl02551 632348002407 Bacterial SH3 domain; Region: SH3_3; cl02551 632348002408 NlpC/P60 family; Region: NLPC_P60; cl11438 632348002409 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 632348002410 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 632348002411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348002412 active site 632348002413 motif I; other site 632348002414 motif II; other site 632348002415 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 632348002416 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 632348002417 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632348002418 shikimate binding site; other site 632348002419 NAD(P) binding site [chemical binding]; other site 632348002420 Response regulator receiver domain; Region: Response_reg; pfam00072 632348002421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348002422 active site 632348002423 phosphorylation site [posttranslational modification] 632348002424 intermolecular recognition site; other site 632348002425 dimerization interface [polypeptide binding]; other site 632348002426 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 632348002427 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 632348002428 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 632348002429 Walker A motif; other site 632348002430 ATP binding site [chemical binding]; other site 632348002431 Walker B motif; other site 632348002432 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 632348002433 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348002434 Walker A motif; other site 632348002435 ATP binding site [chemical binding]; other site 632348002436 Walker B motif; other site 632348002437 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 632348002438 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 632348002439 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 632348002440 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 632348002441 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 632348002442 Late competence development protein ComFB; Region: ComFB; pfam10719 632348002443 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 632348002444 NHL repeat; Region: NHL; pfam01436 632348002445 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 632348002446 NHL repeat; Region: NHL; pfam01436 632348002447 NHL repeat; Region: NHL; pfam01436 632348002448 NHL repeat; Region: NHL; pfam01436 632348002449 endoglucanase; Region: PLN02420 632348002450 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 632348002451 Cellulose binding domain; Region: CBM_3; cl03026 632348002452 Cellulose binding domain; Region: CBM_3; cl03026 632348002453 Cellulose binding domain; Region: CBM_3; cl03026 632348002454 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 632348002455 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348002456 Cellulose binding domain; Region: CBM_3; cl03026 632348002457 Cellulose binding domain; Region: CBM_3; cl03026 632348002458 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 632348002459 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 632348002460 Cellulose binding domain; Region: CBM_3; cl03026 632348002461 Cellulose binding domain; Region: CBM_3; cl03026 632348002462 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 632348002463 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348002464 Cellulose binding domain; Region: CBM_3; cl03026 632348002465 Cellulose binding domain; Region: CBM_3; cl03026 632348002466 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348002467 potential frameshift: common BLAST hit: gi|302872300|ref|YP_003840936.1| Cellulase., Mannan endo-1,4-beta-mannosidase 632348002468 endoglucanase; Region: PLN02420 632348002469 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 632348002470 Cellulose binding domain; Region: CBM_3; cl03026 632348002471 Cellulose binding domain; Region: CBM_3; cl03026 632348002472 Cellulose binding domain; Region: CBM_3; cl03026 632348002473 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348002474 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 632348002475 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 632348002476 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 632348002477 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 632348002478 PPIC-type PPIASE domain; Region: Rotamase; cl08278 632348002479 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 632348002480 Asp-box motif; other site 632348002481 catalytic site [active] 632348002482 Cellulose binding domain; Region: CBM_3; cl03026 632348002483 Cellulose binding domain; Region: CBM_3; cl03026 632348002484 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 632348002485 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348002486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348002487 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 632348002488 Pectate lyase; Region: Pectate_lyase; pfam03211 632348002489 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 632348002490 metal binding site [ion binding]; metal-binding site 632348002491 active site 632348002492 Cellulose binding domain; Region: CBM_3; cl03026 632348002493 Integrase core domain; Region: rve; cl01316 632348002494 Double zinc ribbon; Region: DZR; pfam12773 632348002495 cyclase homology domain; Region: CHD; cd07302 632348002496 nucleotidyl binding site; other site 632348002497 metal binding site [ion binding]; metal-binding site 632348002498 dimer interface [polypeptide binding]; other site 632348002499 Predicted ATPase [General function prediction only]; Region: COG3899 632348002500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348002501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 632348002502 binding surface 632348002503 TPR motif; other site 632348002504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632348002505 GAF domain; Region: GAF; cl15785 632348002506 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632348002507 metal binding site [ion binding]; metal-binding site 632348002508 active site 632348002509 I-site; other site 632348002510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348002511 GAF domain; Region: GAF; cl15785 632348002512 S-layer homology domain; Region: SLH; pfam00395 632348002513 S-layer homology domain; Region: SLH; pfam00395 632348002514 S-layer homology domain; Region: SLH; pfam00395 632348002515 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 632348002516 Fe-S cluster binding site [ion binding]; other site 632348002517 active site 632348002518 acetylornithine aminotransferase; Provisional; Region: PRK02627 632348002519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632348002520 inhibitor-cofactor binding pocket; inhibition site 632348002521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348002522 catalytic residue [active] 632348002523 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 632348002524 Bacitracin resistance protein BacA; Region: BacA; cl00858 632348002525 UGMP family protein; Validated; Region: PRK09604 632348002526 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 632348002527 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 632348002528 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 632348002529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348002530 Zn2+ binding site [ion binding]; other site 632348002531 Mg2+ binding site [ion binding]; other site 632348002532 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 632348002533 elongation factor G; Reviewed; Region: PRK12740 632348002534 G1 box; other site 632348002535 putative GEF interaction site [polypeptide binding]; other site 632348002536 GTP/Mg2+ binding site [chemical binding]; other site 632348002537 Switch I region; other site 632348002538 G2 box; other site 632348002539 G3 box; other site 632348002540 Switch II region; other site 632348002541 G4 box; other site 632348002542 G5 box; other site 632348002543 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 632348002544 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 632348002545 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 632348002546 Probable zinc-binding domain; Region: zf-trcl; pfam13451 632348002547 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 632348002548 NodB motif; other site 632348002549 active site 632348002550 catalytic site [active] 632348002551 Zn binding site [ion binding]; other site 632348002552 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 632348002553 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 632348002554 UvrB/uvrC motif; Region: UVR; pfam02151 632348002555 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 632348002556 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 632348002557 ADP binding site [chemical binding]; other site 632348002558 phosphagen binding site; other site 632348002559 substrate specificity loop; other site 632348002560 Clp protease ATP binding subunit; Region: clpC; CHL00095 632348002561 Clp amino terminal domain; Region: Clp_N; pfam02861 632348002562 Clp amino terminal domain; Region: Clp_N; pfam02861 632348002563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348002564 Walker A motif; other site 632348002565 ATP binding site [chemical binding]; other site 632348002566 Walker B motif; other site 632348002567 arginine finger; other site 632348002568 UvrB/uvrC motif; Region: UVR; pfam02151 632348002569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348002570 Walker A motif; other site 632348002571 ATP binding site [chemical binding]; other site 632348002572 Walker B motif; other site 632348002573 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 632348002574 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 632348002575 active site 632348002576 ADP/pyrophosphate binding site [chemical binding]; other site 632348002577 dimerization interface [polypeptide binding]; other site 632348002578 allosteric effector site; other site 632348002579 fructose-1,6-bisphosphate binding site; other site 632348002580 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 632348002581 Domain of unknown function (DUF814); Region: DUF814; pfam05670 632348002582 O-Antigen ligase; Region: Wzy_C; cl04850 632348002583 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 632348002584 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 632348002585 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348002586 putative homodimer interface [polypeptide binding]; other site 632348002587 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 632348002588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348002589 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632348002590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348002591 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 632348002592 rRNA interaction site [nucleotide binding]; other site 632348002593 S8 interaction site; other site 632348002594 putative laminin-1 binding site; other site 632348002595 elongation factor Ts; Reviewed; Region: tsf; PRK12332 632348002596 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 632348002597 Elongation factor TS; Region: EF_TS; pfam00889 632348002598 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 632348002599 putative nucleotide binding site [chemical binding]; other site 632348002600 uridine monophosphate binding site [chemical binding]; other site 632348002601 homohexameric interface [polypeptide binding]; other site 632348002602 ribosome recycling factor; Reviewed; Region: frr; PRK00083 632348002603 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 632348002604 hinge region; other site 632348002605 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 632348002606 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 632348002607 catalytic residue [active] 632348002608 putative FPP diphosphate binding site; other site 632348002609 putative FPP binding hydrophobic cleft; other site 632348002610 dimer interface [polypeptide binding]; other site 632348002611 putative IPP diphosphate binding site; other site 632348002612 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 632348002613 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 632348002614 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 632348002615 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 632348002616 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 632348002617 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 632348002618 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 632348002619 active site 632348002620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 632348002621 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 632348002622 putative substrate binding region [chemical binding]; other site 632348002623 GcpE protein; Region: GcpE; pfam04551 632348002624 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 632348002625 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 632348002626 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 632348002627 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 632348002628 Ligand binding site; other site 632348002629 Putative Catalytic site; other site 632348002630 DXD motif; other site 632348002631 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 632348002632 DNA polymerase III PolC; Validated; Region: polC; PRK00448 632348002633 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 632348002634 generic binding surface II; other site 632348002635 generic binding surface I; other site 632348002636 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 632348002637 active site 632348002638 catalytic site [active] 632348002639 substrate binding site [chemical binding]; other site 632348002640 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 632348002641 Thiamine pyrophosphokinase; Region: TPK; cd07995 632348002642 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 632348002643 active site 632348002644 dimerization interface [polypeptide binding]; other site 632348002645 thiamine binding site [chemical binding]; other site 632348002646 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 632348002647 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632348002648 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 632348002649 Walker A/P-loop; other site 632348002650 ATP binding site [chemical binding]; other site 632348002651 Q-loop/lid; other site 632348002652 ABC transporter signature motif; other site 632348002653 Walker B; other site 632348002654 D-loop; other site 632348002655 H-loop/switch region; other site 632348002656 TOBE domain; Region: TOBE_2; cl01440 632348002657 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 632348002658 Helix-turn-helix domains; Region: HTH; cl00088 632348002659 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 632348002660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348002661 Walker A/P-loop; other site 632348002662 ATP binding site [chemical binding]; other site 632348002663 Q-loop/lid; other site 632348002664 ABC transporter signature motif; other site 632348002665 Walker B; other site 632348002666 D-loop; other site 632348002667 H-loop/switch region; other site 632348002668 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 632348002669 FtsX-like permease family; Region: FtsX; cl15850 632348002670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 632348002671 Peptidase family M23; Region: Peptidase_M23; pfam01551 632348002672 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 632348002673 protein binding site [polypeptide binding]; other site 632348002674 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 632348002675 Catalytic dyad [active] 632348002676 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632348002677 Peptidase family M23; Region: Peptidase_M23; pfam01551 632348002678 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 632348002679 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632348002680 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 632348002681 germination protein YpeB; Region: spore_YpeB; TIGR02889 632348002682 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632348002683 Germination protease; Region: Peptidase_A25; cl04057 632348002684 stage II sporulation protein P; Region: spore_II_P; TIGR02867 632348002685 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 632348002686 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 632348002687 active site 632348002688 Int/Topo IB signature motif; other site 632348002689 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632348002690 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 632348002691 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 632348002692 catalytic triad [active] 632348002693 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 632348002694 ligand binding site [chemical binding]; other site 632348002695 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632348002696 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 632348002697 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 632348002698 Walker A/P-loop; other site 632348002699 ATP binding site [chemical binding]; other site 632348002700 Q-loop/lid; other site 632348002701 ABC transporter signature motif; other site 632348002702 Walker B; other site 632348002703 D-loop; other site 632348002704 H-loop/switch region; other site 632348002705 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 632348002706 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 632348002707 TM-ABC transporter signature motif; other site 632348002708 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 632348002709 TM-ABC transporter signature motif; other site 632348002710 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632348002711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348002712 DNA-binding site [nucleotide binding]; DNA binding site 632348002713 UTRA domain; Region: UTRA; cl01230 632348002714 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 632348002715 active site 632348002716 catalytic motif [active] 632348002717 Zn binding site [ion binding]; other site 632348002718 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 632348002719 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 632348002720 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 632348002721 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 632348002722 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 632348002723 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 632348002724 intersubunit interface [polypeptide binding]; other site 632348002725 active site 632348002726 catalytic residue [active] 632348002727 Sulfatase; Region: Sulfatase; cl10460 632348002728 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 632348002729 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632348002730 Response regulator receiver domain; Region: Response_reg; pfam00072 632348002731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348002732 active site 632348002733 phosphorylation site [posttranslational modification] 632348002734 intermolecular recognition site; other site 632348002735 dimerization interface [polypeptide binding]; other site 632348002736 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 632348002737 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 632348002738 putative binding surface; other site 632348002739 active site 632348002740 P2 response regulator binding domain; Region: P2; pfam07194 632348002741 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 632348002742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348002743 ATP binding site [chemical binding]; other site 632348002744 Mg2+ binding site [ion binding]; other site 632348002745 G-X-G motif; other site 632348002746 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 632348002747 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 632348002748 putative CheA interaction surface; other site 632348002749 CHASE3 domain; Region: CHASE3; cl05000 632348002750 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 632348002751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348002752 dimerization interface [polypeptide binding]; other site 632348002753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632348002754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348002755 dimer interface [polypeptide binding]; other site 632348002756 putative CheW interface [polypeptide binding]; other site 632348002757 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 632348002758 YtxC-like family; Region: YtxC; cl08500 632348002759 Helix-turn-helix domains; Region: HTH; cl00088 632348002760 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 632348002761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348002762 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 632348002763 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632348002764 protein binding site [polypeptide binding]; other site 632348002765 putative ATPase RIL; Provisional; Region: PRK13409 632348002766 4Fe-4S binding domain; Region: Fer4; cl02805 632348002767 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632348002768 putative homodimer interface [polypeptide binding]; other site 632348002769 putative homotetramer interface [polypeptide binding]; other site 632348002770 putative allosteric switch controlling residues; other site 632348002771 putative metal binding site [ion binding]; other site 632348002772 putative homodimer-homodimer interface [polypeptide binding]; other site 632348002773 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 632348002774 B12 binding site [chemical binding]; other site 632348002775 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 632348002776 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 632348002777 FeS/SAM binding site; other site 632348002778 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 632348002779 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 632348002780 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 632348002781 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 632348002782 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 632348002783 oligomer interface [polypeptide binding]; other site 632348002784 putative active site [active] 632348002785 metal binding site [ion binding]; metal-binding site 632348002786 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632348002787 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 632348002788 active site 632348002789 substrate binding site [chemical binding]; other site 632348002790 metal binding site [ion binding]; metal-binding site 632348002791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632348002792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348002793 active site 632348002794 phosphorylation site [posttranslational modification] 632348002795 intermolecular recognition site; other site 632348002796 dimerization interface [polypeptide binding]; other site 632348002797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632348002798 DNA binding site [nucleotide binding] 632348002799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632348002800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632348002801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632348002802 dimer interface [polypeptide binding]; other site 632348002803 phosphorylation site [posttranslational modification] 632348002804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348002805 ATP binding site [chemical binding]; other site 632348002806 Mg2+ binding site [ion binding]; other site 632348002807 G-X-G motif; other site 632348002808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348002809 Zn2+ binding site [ion binding]; other site 632348002810 Mg2+ binding site [ion binding]; other site 632348002811 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348002812 Zn2+ binding site [ion binding]; other site 632348002813 Mg2+ binding site [ion binding]; other site 632348002814 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 632348002815 Ferritin-like domain; Region: Ferritin; pfam00210 632348002816 dinuclear metal binding motif [ion binding]; other site 632348002817 Rubrerythrin [Energy production and conversion]; Region: COG1592 632348002818 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 632348002819 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 632348002820 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 632348002821 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 632348002822 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 632348002823 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 632348002824 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 632348002825 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 632348002826 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 632348002827 putative translocon binding site; other site 632348002828 protein-rRNA interface [nucleotide binding]; other site 632348002829 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 632348002830 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 632348002831 G-X-X-G motif; other site 632348002832 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 632348002833 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 632348002834 23S rRNA interface [nucleotide binding]; other site 632348002835 5S rRNA interface [nucleotide binding]; other site 632348002836 putative antibiotic binding site [chemical binding]; other site 632348002837 L25 interface [polypeptide binding]; other site 632348002838 L27 interface [polypeptide binding]; other site 632348002839 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 632348002840 23S rRNA interface [nucleotide binding]; other site 632348002841 putative translocon interaction site; other site 632348002842 signal recognition particle (SRP54) interaction site; other site 632348002843 L23 interface [polypeptide binding]; other site 632348002844 trigger factor interaction site; other site 632348002845 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 632348002846 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 632348002847 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 632348002848 KOW motif; Region: KOW; cl00354 632348002849 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 632348002850 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 632348002851 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 632348002852 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 632348002853 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 632348002854 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 632348002855 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 632348002856 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 632348002857 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 632348002858 23S rRNA interface [nucleotide binding]; other site 632348002859 5S rRNA interface [nucleotide binding]; other site 632348002860 L27 interface [polypeptide binding]; other site 632348002861 L5 interface [polypeptide binding]; other site 632348002862 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 632348002863 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 632348002864 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 632348002865 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 632348002866 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 632348002867 SecY translocase; Region: SecY; pfam00344 632348002868 adenylate kinase; Reviewed; Region: adk; PRK00279 632348002869 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 632348002870 AMP-binding site [chemical binding]; other site 632348002871 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 632348002872 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 632348002873 active site 632348002874 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 632348002875 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 632348002876 rRNA binding site [nucleotide binding]; other site 632348002877 predicted 30S ribosome binding site; other site 632348002878 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 632348002879 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 632348002880 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 632348002881 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 632348002882 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 632348002883 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 632348002884 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632348002885 RNA binding surface [nucleotide binding]; other site 632348002886 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 632348002887 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 632348002888 alphaNTD homodimer interface [polypeptide binding]; other site 632348002889 alphaNTD - beta interaction site [polypeptide binding]; other site 632348002890 alphaNTD - beta' interaction site [polypeptide binding]; other site 632348002891 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 632348002892 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 632348002893 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 632348002894 Helix-turn-helix domains; Region: HTH; cl00088 632348002895 Rrf2 family protein; Region: rrf2_super; TIGR00738 632348002896 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632348002897 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 632348002898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632348002899 catalytic residue [active] 632348002900 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 632348002901 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 632348002902 trimerization site [polypeptide binding]; other site 632348002903 active site 632348002904 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 632348002905 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 632348002906 Ligand Binding Site [chemical binding]; other site 632348002907 histidinol-phosphatase; Provisional; Region: PRK05588 632348002908 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 632348002909 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 632348002910 active site 632348002911 NTP binding site [chemical binding]; other site 632348002912 metal binding triad [ion binding]; metal-binding site 632348002913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 632348002914 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 632348002915 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 632348002916 4Fe-4S binding domain; Region: Fer4; cl02805 632348002917 4Fe-4S binding domain; Region: Fer4; cl02805 632348002918 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 632348002919 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 632348002920 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632348002921 dimer interface [polypeptide binding]; other site 632348002922 PYR/PP interface [polypeptide binding]; other site 632348002923 TPP binding site [chemical binding]; other site 632348002924 substrate binding site [chemical binding]; other site 632348002925 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632348002926 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 632348002927 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 632348002928 TPP-binding site [chemical binding]; other site 632348002929 putative dimer interface [polypeptide binding]; other site 632348002930 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 632348002931 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632348002932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348002933 Walker A/P-loop; other site 632348002934 ATP binding site [chemical binding]; other site 632348002935 Q-loop/lid; other site 632348002936 ABC transporter signature motif; other site 632348002937 Walker B; other site 632348002938 D-loop; other site 632348002939 H-loop/switch region; other site 632348002940 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 632348002941 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 632348002942 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 632348002943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348002944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348002945 DNA binding residues [nucleotide binding] 632348002946 shikimate kinase; Reviewed; Region: aroK; PRK00131 632348002947 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 632348002948 ADP binding site [chemical binding]; other site 632348002949 magnesium binding site [ion binding]; other site 632348002950 putative shikimate binding site; other site 632348002951 AP endonuclease family 2; Region: AP2Ec; smart00518 632348002952 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632348002953 DNA interaction; other site 632348002954 Metal-binding active site; metal-binding site 632348002955 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 632348002956 trimer interface [polypeptide binding]; other site 632348002957 active site 632348002958 dimer interface [polypeptide binding]; other site 632348002959 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 632348002960 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 632348002961 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 632348002962 active site 632348002963 chorismate binding enzyme; Region: Chorismate_bind; cl10555 632348002964 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 632348002965 Glutamine amidotransferase class-I; Region: GATase; pfam00117 632348002966 glutamine binding [chemical binding]; other site 632348002967 catalytic triad [active] 632348002968 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 632348002969 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 632348002970 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 632348002971 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 632348002972 active site 632348002973 ribulose/triose binding site [chemical binding]; other site 632348002974 phosphate binding site [ion binding]; other site 632348002975 substrate (anthranilate) binding pocket [chemical binding]; other site 632348002976 product (indole) binding pocket [chemical binding]; other site 632348002977 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 632348002978 active site 632348002979 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 632348002980 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 632348002981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348002982 catalytic residue [active] 632348002983 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 632348002984 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 632348002985 substrate binding site [chemical binding]; other site 632348002986 active site 632348002987 catalytic residues [active] 632348002988 heterodimer interface [polypeptide binding]; other site 632348002989 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 632348002990 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 632348002991 Walker A/P-loop; other site 632348002992 ATP binding site [chemical binding]; other site 632348002993 Q-loop/lid; other site 632348002994 ABC transporter signature motif; other site 632348002995 Walker B; other site 632348002996 D-loop; other site 632348002997 H-loop/switch region; other site 632348002998 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 632348002999 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 632348003000 Walker A/P-loop; other site 632348003001 ATP binding site [chemical binding]; other site 632348003002 Q-loop/lid; other site 632348003003 ABC transporter signature motif; other site 632348003004 Walker B; other site 632348003005 D-loop; other site 632348003006 H-loop/switch region; other site 632348003007 Cobalt transport protein; Region: CbiQ; cl00463 632348003008 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 632348003009 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 632348003010 dimerization interface 3.5A [polypeptide binding]; other site 632348003011 active site 632348003012 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 632348003013 putative active site [active] 632348003014 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632348003015 anti sigma factor interaction site; other site 632348003016 regulatory phosphorylation site [posttranslational modification]; other site 632348003017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632348003018 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 632348003019 sporulation sigma factor SigF; Validated; Region: PRK05572 632348003020 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348003021 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632348003022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348003023 DNA binding residues [nucleotide binding] 632348003024 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 632348003025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348003026 active site 632348003027 flagellar operon protein TIGR03826; Region: YvyF 632348003028 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 632348003029 FlgN protein; Region: FlgN; cl09176 632348003030 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 632348003031 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 632348003032 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 632348003033 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 632348003034 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 632348003035 Protein of unknown function DUF86; Region: DUF86; cl01031 632348003036 FliW protein; Region: FliW; cl00740 632348003037 Global regulator protein family; Region: CsrA; cl00670 632348003038 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 632348003039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348003040 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632348003041 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632348003042 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632348003043 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632348003044 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632348003045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348003046 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 632348003047 ATP binding site [chemical binding]; other site 632348003048 putative Mg++ binding site [ion binding]; other site 632348003049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348003050 nucleotide binding region [chemical binding]; other site 632348003051 ATP-binding site [chemical binding]; other site 632348003052 flagellin; Provisional; Region: PRK12804 632348003053 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 632348003054 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 632348003055 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632348003056 active site 632348003057 Tetratricopeptide repeat; Region: TPR_16; pfam13432 632348003058 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 632348003059 putative homodimer interface [polypeptide binding]; other site 632348003060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 632348003061 active site 632348003062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348003063 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632348003064 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 632348003065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348003066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348003067 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632348003068 FeS/SAM binding site; other site 632348003069 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 632348003070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348003071 FeS/SAM binding site; other site 632348003072 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 632348003073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348003074 FeS/SAM binding site; other site 632348003075 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 632348003076 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 632348003077 substrate binding site; other site 632348003078 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 632348003079 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 632348003080 NAD binding site [chemical binding]; other site 632348003081 homotetramer interface [polypeptide binding]; other site 632348003082 homodimer interface [polypeptide binding]; other site 632348003083 substrate binding site [chemical binding]; other site 632348003084 active site 632348003085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348003086 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 632348003087 NAD(P) binding site [chemical binding]; other site 632348003088 active site 632348003089 Cupin domain; Region: Cupin_2; cl09118 632348003090 EcoRII C terminal; Region: EcoRII-C; pfam09019 632348003091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348003092 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632348003093 active site 632348003094 NTP binding site [chemical binding]; other site 632348003095 metal binding triad [ion binding]; metal-binding site 632348003096 FlaG protein; Region: FlaG; cl00591 632348003097 flagellar capping protein; Validated; Region: fliD; PRK07737 632348003098 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 632348003099 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 632348003100 Flagellar protein FliS; Region: FliS; cl00654 632348003101 FlgN protein; Region: FlgN; cl09176 632348003102 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 632348003103 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 632348003104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348003105 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 632348003106 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 632348003107 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 632348003108 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 632348003109 nucleotide binding site [chemical binding]; other site 632348003110 homotetrameric interface [polypeptide binding]; other site 632348003111 putative phosphate binding site [ion binding]; other site 632348003112 putative allosteric binding site; other site 632348003113 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 632348003114 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 632348003115 putative catalytic cysteine [active] 632348003116 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632348003117 active site 632348003118 NTP binding site [chemical binding]; other site 632348003119 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 632348003120 metal binding triad [ion binding]; metal-binding site 632348003121 metal binding triad [ion binding]; metal-binding site 632348003122 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 632348003123 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 632348003124 Walker A/P-loop; other site 632348003125 ATP binding site [chemical binding]; other site 632348003126 Q-loop/lid; other site 632348003127 ABC transporter signature motif; other site 632348003128 Walker B; other site 632348003129 D-loop; other site 632348003130 H-loop/switch region; other site 632348003131 Smr domain; Region: Smr; cl02619 632348003132 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 632348003133 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 632348003134 Catalytic site [active] 632348003135 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 632348003136 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 632348003137 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 632348003138 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 632348003139 active site 632348003140 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 632348003141 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 632348003142 active site 632348003143 catalytic residues [active] 632348003144 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 632348003145 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 632348003146 Ligand Binding Site [chemical binding]; other site 632348003147 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 632348003148 AIR carboxylase; Region: AIRC; cl00310 632348003149 GTP-binding protein YchF; Reviewed; Region: PRK09601 632348003150 YchF GTPase; Region: YchF; cd01900 632348003151 G1 box; other site 632348003152 GTP/Mg2+ binding site [chemical binding]; other site 632348003153 Switch I region; other site 632348003154 G2 box; other site 632348003155 Switch II region; other site 632348003156 G3 box; other site 632348003157 G4 box; other site 632348003158 G5 box; other site 632348003159 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 632348003160 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 632348003161 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632348003162 catalytic residue [active] 632348003163 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 632348003164 Heme NO binding; Region: HNOB; cl15268 632348003165 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632348003166 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348003167 dimer interface [polypeptide binding]; other site 632348003168 putative CheW interface [polypeptide binding]; other site 632348003169 EamA-like transporter family; Region: EamA; cl01037 632348003170 Cupin domain; Region: Cupin_2; cl09118 632348003171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348003172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348003173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348003174 Protein of unknown function (DUF541); Region: SIMPL; cl01077 632348003175 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632348003176 catalytic residues [active] 632348003177 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632348003178 putative homodimer interface [polypeptide binding]; other site 632348003179 putative homotetramer interface [polypeptide binding]; other site 632348003180 putative allosteric switch controlling residues; other site 632348003181 putative metal binding site [ion binding]; other site 632348003182 putative homodimer-homodimer interface [polypeptide binding]; other site 632348003183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348003184 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 632348003185 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 632348003186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348003187 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 632348003188 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 632348003189 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 632348003190 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 632348003191 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 632348003192 nucleotide binding pocket [chemical binding]; other site 632348003193 K-X-D-G motif; other site 632348003194 catalytic site [active] 632348003195 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 632348003196 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 632348003197 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 632348003198 Dimer interface [polypeptide binding]; other site 632348003199 BRCT sequence motif; other site 632348003200 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 632348003201 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632348003202 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 632348003203 active site 632348003204 ATP binding site [chemical binding]; other site 632348003205 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 632348003206 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 632348003207 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632348003208 dimer interface [polypeptide binding]; other site 632348003209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348003210 catalytic residue [active] 632348003211 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 632348003212 hypothetical protein; Provisional; Region: PRK04328 632348003213 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348003214 Walker A motif; other site 632348003215 ATP binding site [chemical binding]; other site 632348003216 Walker B motif; other site 632348003217 Peptidase family M48; Region: Peptidase_M48; cl12018 632348003218 Peptidase family M48; Region: Peptidase_M48; cl12018 632348003219 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 632348003220 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632348003221 DNA binding residues [nucleotide binding] 632348003222 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 632348003223 catalytic residues [active] 632348003224 catalytic nucleophile [active] 632348003225 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632348003226 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632348003227 Restriction endonuclease; Region: Mrr_cat; cl00516 632348003228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632348003229 ATP binding site [chemical binding]; other site 632348003230 putative Mg++ binding site [ion binding]; other site 632348003231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348003232 nucleotide binding region [chemical binding]; other site 632348003233 ATP-binding site [chemical binding]; other site 632348003234 Protein of unknown function (DUF499); Region: DUF499; pfam04465 632348003235 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 632348003236 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 632348003237 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 632348003238 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 632348003239 putative active site [active] 632348003240 catalytic site [active] 632348003241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632348003242 ATP binding site [chemical binding]; other site 632348003243 putative Mg++ binding site [ion binding]; other site 632348003244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348003245 nucleotide binding region [chemical binding]; other site 632348003246 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 632348003247 AAA domain; Region: AAA_23; pfam13476 632348003248 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 632348003249 ABC transporter signature motif; other site 632348003250 Walker B; other site 632348003251 D-loop; other site 632348003252 H-loop/switch region; other site 632348003253 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 632348003254 active site 632348003255 metal binding site [ion binding]; metal-binding site 632348003256 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 632348003257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348003258 Walker A motif; other site 632348003259 ATP binding site [chemical binding]; other site 632348003260 Walker B motif; other site 632348003261 arginine finger; other site 632348003262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632348003263 binding surface 632348003264 TPR motif; other site 632348003265 TPR repeat; Region: TPR_11; pfam13414 632348003266 TPR repeat; Region: TPR_11; pfam13414 632348003267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 632348003268 binding surface 632348003269 TPR motif; other site 632348003270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348003271 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 632348003272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348003273 Walker A motif; other site 632348003274 ATP binding site [chemical binding]; other site 632348003275 Walker B motif; other site 632348003276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632348003277 Helix-turn-helix domains; Region: HTH; cl00088 632348003278 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348003279 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 632348003280 Walker A/P-loop; other site 632348003281 ATP binding site [chemical binding]; other site 632348003282 Q-loop/lid; other site 632348003283 ABC transporter signature motif; other site 632348003284 Walker B; other site 632348003285 D-loop; other site 632348003286 H-loop/switch region; other site 632348003287 FtsX-like permease family; Region: FtsX; cl15850 632348003288 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 632348003289 FtsX-like permease family; Region: FtsX; cl15850 632348003290 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632348003291 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 632348003292 Walker A/P-loop; other site 632348003293 ATP binding site [chemical binding]; other site 632348003294 Q-loop/lid; other site 632348003295 ABC transporter signature motif; other site 632348003296 Walker B; other site 632348003297 D-loop; other site 632348003298 H-loop/switch region; other site 632348003299 Putative zinc-finger; Region: zf-HC2; cl15806 632348003300 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 632348003301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348003302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348003303 DNA binding residues [nucleotide binding] 632348003304 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632348003305 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 632348003306 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 632348003307 putative FMN binding site [chemical binding]; other site 632348003308 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 632348003309 Flavin Reductases; Region: FlaRed; cl00801 632348003310 FeoA domain; Region: FeoA; cl00838 632348003311 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 632348003312 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 632348003313 G1 box; other site 632348003314 GTP/Mg2+ binding site [chemical binding]; other site 632348003315 Switch I region; other site 632348003316 G2 box; other site 632348003317 G3 box; other site 632348003318 Switch II region; other site 632348003319 G4 box; other site 632348003320 G5 box; other site 632348003321 Nucleoside recognition; Region: Gate; cl00486 632348003322 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 632348003323 Nucleoside recognition; Region: Gate; cl00486 632348003324 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632348003325 metal binding site 2 [ion binding]; metal-binding site 632348003326 putative DNA binding helix; other site 632348003327 metal binding site 1 [ion binding]; metal-binding site 632348003328 dimer interface [polypeptide binding]; other site 632348003329 structural Zn2+ binding site [ion binding]; other site 632348003330 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 632348003331 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 632348003332 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 632348003333 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 632348003334 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 632348003335 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 632348003336 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 632348003337 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 632348003338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348003339 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632348003340 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 632348003341 active site 632348003342 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 632348003343 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 632348003344 putative active site [active] 632348003345 putative metal binding site [ion binding]; other site 632348003346 GTP-binding protein LepA; Provisional; Region: PRK05433 632348003347 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 632348003348 G1 box; other site 632348003349 putative GEF interaction site [polypeptide binding]; other site 632348003350 GTP/Mg2+ binding site [chemical binding]; other site 632348003351 Switch I region; other site 632348003352 G2 box; other site 632348003353 G3 box; other site 632348003354 Switch II region; other site 632348003355 G4 box; other site 632348003356 G5 box; other site 632348003357 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 632348003358 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 632348003359 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 632348003360 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 632348003361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348003362 FeS/SAM binding site; other site 632348003363 HemN C-terminal domain; Region: HemN_C; pfam06969 632348003364 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 632348003365 Helix-turn-helix domains; Region: HTH; cl00088 632348003366 HrcA protein C terminal domain; Region: HrcA; pfam01628 632348003367 heat shock protein GrpE; Provisional; Region: PRK14140 632348003368 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 632348003369 dimer interface [polypeptide binding]; other site 632348003370 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 632348003371 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 632348003372 chaperone protein DnaJ; Provisional; Region: PRK14277 632348003373 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632348003374 HSP70 interaction site [polypeptide binding]; other site 632348003375 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 632348003376 substrate binding site [polypeptide binding]; other site 632348003377 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 632348003378 Zn binding sites [ion binding]; other site 632348003379 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 632348003380 dimer interface [polypeptide binding]; other site 632348003381 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 632348003382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348003383 S-adenosylmethionine binding site [chemical binding]; other site 632348003384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 632348003385 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 632348003386 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632348003387 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 632348003388 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632348003389 catalytic residue [active] 632348003390 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 632348003391 THUMP domain; Region: THUMP; cl12076 632348003392 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 632348003393 Ligand Binding Site [chemical binding]; other site 632348003394 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 632348003395 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 632348003396 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 632348003397 active site 632348003398 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 632348003399 ornithine carbamoyltransferase; Provisional; Region: PRK00779 632348003400 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 632348003401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348003402 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 632348003403 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632348003404 ATP-grasp domain; Region: ATP-grasp_4; cl03087 632348003405 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 632348003406 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632348003407 ATP-grasp domain; Region: ATP-grasp_4; cl03087 632348003408 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 632348003409 substrate binding site [chemical binding]; other site 632348003410 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 632348003411 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 632348003412 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 632348003413 catalytic site [active] 632348003414 subunit interface [polypeptide binding]; other site 632348003415 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 632348003416 active site 632348003417 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 632348003418 dimer interface [polypeptide binding]; other site 632348003419 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 632348003420 Ligand Binding Site [chemical binding]; other site 632348003421 Molecular Tunnel; other site 632348003422 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 632348003423 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632348003424 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632348003425 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632348003426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348003427 DNA-binding site [nucleotide binding]; DNA binding site 632348003428 FCD domain; Region: FCD; cl11656 632348003429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632348003430 active site 632348003431 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 632348003432 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 632348003433 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 632348003434 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 632348003435 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 632348003436 putative homodimer interface [polypeptide binding]; other site 632348003437 KOW motif; Region: KOW; cl00354 632348003438 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 632348003439 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 632348003440 23S rRNA interface [nucleotide binding]; other site 632348003441 L7/L12 interface [polypeptide binding]; other site 632348003442 putative thiostrepton binding site; other site 632348003443 L25 interface [polypeptide binding]; other site 632348003444 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 632348003445 mRNA/rRNA interface [nucleotide binding]; other site 632348003446 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 632348003447 23S rRNA interface [nucleotide binding]; other site 632348003448 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 632348003449 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 632348003450 core dimer interface [polypeptide binding]; other site 632348003451 peripheral dimer interface [polypeptide binding]; other site 632348003452 L10 interface [polypeptide binding]; other site 632348003453 L11 interface [polypeptide binding]; other site 632348003454 putative EF-Tu interaction site [polypeptide binding]; other site 632348003455 putative EF-G interaction site [polypeptide binding]; other site 632348003456 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348003457 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348003458 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 632348003459 Walker A/P-loop; other site 632348003460 ATP binding site [chemical binding]; other site 632348003461 Q-loop/lid; other site 632348003462 ABC transporter signature motif; other site 632348003463 Walker B; other site 632348003464 D-loop; other site 632348003465 H-loop/switch region; other site 632348003466 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348003467 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348003468 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348003469 Walker A/P-loop; other site 632348003470 ATP binding site [chemical binding]; other site 632348003471 Q-loop/lid; other site 632348003472 ABC transporter signature motif; other site 632348003473 Walker B; other site 632348003474 D-loop; other site 632348003475 H-loop/switch region; other site 632348003476 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 632348003477 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 632348003478 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632348003479 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 632348003480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348003481 motif II; other site 632348003482 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 632348003483 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 632348003484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632348003485 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632348003486 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 632348003487 active site residue [active] 632348003488 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 632348003489 substrate binding site; other site 632348003490 dimer interface; other site 632348003491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348003492 AAA domain; Region: AAA_32; pfam13654 632348003493 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348003494 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348003495 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 632348003496 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 632348003497 putative FMN binding site [chemical binding]; other site 632348003498 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 632348003499 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 632348003500 GAF domain; Region: GAF_2; pfam13185 632348003501 GAF domain; Region: GAF; cl15785 632348003502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632348003503 metal binding site [ion binding]; metal-binding site 632348003504 active site 632348003505 I-site; other site 632348003506 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 632348003507 ATP cone domain; Region: ATP-cone; pfam03477 632348003508 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 632348003509 putative dimer interface [polypeptide binding]; other site 632348003510 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 632348003511 Clp amino terminal domain; Region: Clp_N; pfam02861 632348003512 Clp amino terminal domain; Region: Clp_N; pfam02861 632348003513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348003514 Walker A motif; other site 632348003515 ATP binding site [chemical binding]; other site 632348003516 Walker B motif; other site 632348003517 arginine finger; other site 632348003518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348003519 Walker A motif; other site 632348003520 ATP binding site [chemical binding]; other site 632348003521 Walker B motif; other site 632348003522 arginine finger; other site 632348003523 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 632348003524 AMP-binding enzyme; Region: AMP-binding; cl15778 632348003525 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 632348003526 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 632348003527 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632348003528 dimer interface [polypeptide binding]; other site 632348003529 PYR/PP interface [polypeptide binding]; other site 632348003530 TPP binding site [chemical binding]; other site 632348003531 substrate binding site [chemical binding]; other site 632348003532 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 632348003533 TPP-binding site; other site 632348003534 4Fe-4S binding domain; Region: Fer4; cl02805 632348003535 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 632348003536 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 632348003537 AMP-binding enzyme; Region: AMP-binding; cl15778 632348003538 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 632348003539 ACT domain-containing protein [General function prediction only]; Region: COG4747 632348003540 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 632348003541 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 632348003542 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632348003543 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 632348003544 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632348003545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348003546 FeS/SAM binding site; other site 632348003547 TRAM domain; Region: TRAM; cl01282 632348003548 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 632348003549 MutS domain I; Region: MutS_I; pfam01624 632348003550 MutS domain II; Region: MutS_II; pfam05188 632348003551 MutS family domain IV; Region: MutS_IV; pfam05190 632348003552 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 632348003553 Walker A/P-loop; other site 632348003554 ATP binding site [chemical binding]; other site 632348003555 Q-loop/lid; other site 632348003556 ABC transporter signature motif; other site 632348003557 Walker B; other site 632348003558 D-loop; other site 632348003559 H-loop/switch region; other site 632348003560 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 632348003561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348003562 ATP binding site [chemical binding]; other site 632348003563 Mg2+ binding site [ion binding]; other site 632348003564 G-X-G motif; other site 632348003565 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 632348003566 ATP binding site [chemical binding]; other site 632348003567 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 632348003568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348003569 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 632348003570 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 632348003571 Sm1 motif; other site 632348003572 D1 - D2 interaction site; other site 632348003573 D3 - B interaction site; other site 632348003574 Hfq - Hfq interaction site; other site 632348003575 RNA binding pocket [nucleotide binding]; other site 632348003576 Sm2 motif; other site 632348003577 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 632348003578 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632348003579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632348003580 catalytic residue [active] 632348003581 LexA repressor; Validated; Region: PRK00215 632348003582 Helix-turn-helix domains; Region: HTH; cl00088 632348003583 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632348003584 Catalytic site [active] 632348003585 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 632348003586 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 632348003587 Acetokinase family; Region: Acetate_kinase; cl01029 632348003588 propionate/acetate kinase; Provisional; Region: PRK12379 632348003589 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 632348003590 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 632348003591 non-heme iron binding site [ion binding]; other site 632348003592 dimer interface [polypeptide binding]; other site 632348003593 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 632348003594 non-heme iron binding site [ion binding]; other site 632348003595 dimer interface [polypeptide binding]; other site 632348003596 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 632348003597 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632348003598 active site 632348003599 HIGH motif; other site 632348003600 nucleotide binding site [chemical binding]; other site 632348003601 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632348003602 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 632348003603 active site 632348003604 KMSKS motif; other site 632348003605 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 632348003606 tRNA binding surface [nucleotide binding]; other site 632348003607 anticodon binding site; other site 632348003608 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 632348003609 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632348003610 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632348003611 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 632348003612 active site 632348003613 intersubunit interactions; other site 632348003614 catalytic residue [active] 632348003615 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 632348003616 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 632348003617 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632348003618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348003619 active site 632348003620 phosphorylation site [posttranslational modification] 632348003621 intermolecular recognition site; other site 632348003622 dimerization interface [polypeptide binding]; other site 632348003623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632348003624 DNA binding site [nucleotide binding] 632348003625 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 632348003626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632348003627 dimer interface [polypeptide binding]; other site 632348003628 phosphorylation site [posttranslational modification] 632348003629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348003630 ATP binding site [chemical binding]; other site 632348003631 Mg2+ binding site [ion binding]; other site 632348003632 G-X-G motif; other site 632348003633 Phosphate transporter family; Region: PHO4; cl00396 632348003634 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 632348003635 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 632348003636 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 632348003637 Walker A/P-loop; other site 632348003638 ATP binding site [chemical binding]; other site 632348003639 Q-loop/lid; other site 632348003640 ABC transporter signature motif; other site 632348003641 Walker B; other site 632348003642 D-loop; other site 632348003643 H-loop/switch region; other site 632348003644 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 632348003645 PhoU domain; Region: PhoU; pfam01895 632348003646 PhoU domain; Region: PhoU; pfam01895 632348003647 QueT transporter; Region: QueT; cl01932 632348003648 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 632348003649 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 632348003650 dimer interface [polypeptide binding]; other site 632348003651 motif 1; other site 632348003652 active site 632348003653 motif 2; other site 632348003654 motif 3; other site 632348003655 ATP phosphoribosyltransferase; Region: HisG; cl15266 632348003656 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 632348003657 histidinol dehydrogenase; Region: hisD; TIGR00069 632348003658 NAD binding site [chemical binding]; other site 632348003659 dimerization interface [polypeptide binding]; other site 632348003660 product binding site; other site 632348003661 substrate binding site [chemical binding]; other site 632348003662 zinc binding site [ion binding]; other site 632348003663 catalytic residues [active] 632348003664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632348003665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348003666 homodimer interface [polypeptide binding]; other site 632348003667 catalytic residue [active] 632348003668 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 632348003669 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 632348003670 putative active site pocket [active] 632348003671 4-fold oligomerization interface [polypeptide binding]; other site 632348003672 metal binding residues [ion binding]; metal-binding site 632348003673 3-fold/trimer interface [polypeptide binding]; other site 632348003674 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 632348003675 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 632348003676 putative active site [active] 632348003677 oxyanion strand; other site 632348003678 catalytic triad [active] 632348003679 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 632348003680 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 632348003681 catalytic residues [active] 632348003682 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 632348003683 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 632348003684 substrate binding site [chemical binding]; other site 632348003685 glutamase interaction surface [polypeptide binding]; other site 632348003686 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 632348003687 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 632348003688 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 632348003689 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 632348003690 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 632348003691 Substrate binding site; other site 632348003692 Cupin domain; Region: Cupin_2; cl09118 632348003693 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 632348003694 MatE; Region: MatE; cl10513 632348003695 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 632348003696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632348003697 Coenzyme A binding pocket [chemical binding]; other site 632348003698 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 632348003699 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632348003700 minor groove reading motif; other site 632348003701 helix-hairpin-helix signature motif; other site 632348003702 substrate binding pocket [chemical binding]; other site 632348003703 active site 632348003704 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 632348003705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 632348003706 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 632348003707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 632348003708 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 632348003709 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 632348003710 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 632348003711 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 632348003712 putative ATP binding site [chemical binding]; other site 632348003713 putative substrate interface [chemical binding]; other site 632348003714 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 632348003715 NodB motif; other site 632348003716 active site 632348003717 catalytic site [active] 632348003718 metal binding site [ion binding]; metal-binding site 632348003719 single-stranded DNA-binding protein; Provisional; Region: PRK05813 632348003720 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632348003721 dimer interface [polypeptide binding]; other site 632348003722 ssDNA binding site [nucleotide binding]; other site 632348003723 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632348003724 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 632348003725 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 632348003726 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 632348003727 dimerization interface [polypeptide binding]; other site 632348003728 putative ATP binding site [chemical binding]; other site 632348003729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632348003730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348003731 active site 632348003732 phosphorylation site [posttranslational modification] 632348003733 intermolecular recognition site; other site 632348003734 dimerization interface [polypeptide binding]; other site 632348003735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632348003736 DNA binding site [nucleotide binding] 632348003737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632348003738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348003739 dimerization interface [polypeptide binding]; other site 632348003740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632348003741 dimer interface [polypeptide binding]; other site 632348003742 phosphorylation site [posttranslational modification] 632348003743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348003744 ATP binding site [chemical binding]; other site 632348003745 Mg2+ binding site [ion binding]; other site 632348003746 G-X-G motif; other site 632348003747 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 632348003748 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 632348003749 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632348003750 protein binding site [polypeptide binding]; other site 632348003751 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 632348003752 Sulfate transporter family; Region: Sulfate_transp; cl15842 632348003753 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 632348003754 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 632348003755 ATP binding site [chemical binding]; other site 632348003756 active site 632348003757 substrate binding site [chemical binding]; other site 632348003758 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 632348003759 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 632348003760 putative active site [active] 632348003761 catalytic triad [active] 632348003762 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 632348003763 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 632348003764 dimerization interface [polypeptide binding]; other site 632348003765 ATP binding site [chemical binding]; other site 632348003766 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 632348003767 dimerization interface [polypeptide binding]; other site 632348003768 ATP binding site [chemical binding]; other site 632348003769 amidophosphoribosyltransferase; Provisional; Region: PRK05793 632348003770 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 632348003771 active site 632348003772 tetramer interface [polypeptide binding]; other site 632348003773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348003774 active site 632348003775 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 632348003776 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 632348003777 dimerization interface [polypeptide binding]; other site 632348003778 putative ATP binding site [chemical binding]; other site 632348003779 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 632348003780 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 632348003781 active site 632348003782 substrate binding site [chemical binding]; other site 632348003783 cosubstrate binding site; other site 632348003784 catalytic site [active] 632348003785 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 632348003786 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 632348003787 purine monophosphate binding site [chemical binding]; other site 632348003788 dimer interface [polypeptide binding]; other site 632348003789 putative catalytic residues [active] 632348003790 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 632348003791 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 632348003792 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 632348003793 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 632348003794 ATP-grasp domain; Region: ATP-grasp_4; cl03087 632348003795 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 632348003796 Rubredoxin; Region: Rubredoxin; pfam00301 632348003797 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 632348003798 iron binding site [ion binding]; other site 632348003799 DNA polymerase I; Provisional; Region: PRK05755 632348003800 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 632348003801 active site 632348003802 metal binding site 1 [ion binding]; metal-binding site 632348003803 putative 5' ssDNA interaction site; other site 632348003804 metal binding site 3; metal-binding site 632348003805 metal binding site 2 [ion binding]; metal-binding site 632348003806 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 632348003807 putative DNA binding site [nucleotide binding]; other site 632348003808 putative metal binding site [ion binding]; other site 632348003809 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 632348003810 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 632348003811 active site 632348003812 DNA binding site [nucleotide binding] 632348003813 catalytic site [active] 632348003814 dephospho-CoA kinase; Region: TIGR00152 632348003815 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 632348003816 CoA-binding site [chemical binding]; other site 632348003817 ATP-binding [chemical binding]; other site 632348003818 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 632348003819 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632348003820 catalytic residue [active] 632348003821 excinuclease ABC subunit B; Provisional; Region: PRK05298 632348003822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632348003823 ATP binding site [chemical binding]; other site 632348003824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348003825 nucleotide binding region [chemical binding]; other site 632348003826 ATP-binding site [chemical binding]; other site 632348003827 Ultra-violet resistance protein B; Region: UvrB; pfam12344 632348003828 UvrB/uvrC motif; Region: UVR; pfam02151 632348003829 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 632348003830 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 632348003831 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 632348003832 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 632348003833 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 632348003834 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 632348003835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348003836 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 632348003837 Membrane transport protein; Region: Mem_trans; cl09117 632348003838 GMP synthase; Reviewed; Region: guaA; PRK00074 632348003839 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 632348003840 AMP/PPi binding site [chemical binding]; other site 632348003841 candidate oxyanion hole; other site 632348003842 catalytic triad [active] 632348003843 potential glutamine specificity residues [chemical binding]; other site 632348003844 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 632348003845 ATP Binding subdomain [chemical binding]; other site 632348003846 Ligand Binding sites [chemical binding]; other site 632348003847 Dimerization subdomain; other site 632348003848 ATP synthase A chain; Region: ATP-synt_A; cl00413 632348003849 ATP synthase subunit C; Region: ATP-synt_C; cl00466 632348003850 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 632348003851 Plant ATP synthase F0; Region: YMF19; cl07975 632348003852 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 632348003853 Plant ATP synthase F0; Region: YMF19; cl07975 632348003854 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 632348003855 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 632348003856 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 632348003857 beta subunit interaction interface [polypeptide binding]; other site 632348003858 Walker A motif; other site 632348003859 ATP binding site [chemical binding]; other site 632348003860 Walker B motif; other site 632348003861 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 632348003862 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 632348003863 ATP synthase; Region: ATP-synt; cl00365 632348003864 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 632348003865 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 632348003866 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 632348003867 alpha subunit interaction interface [polypeptide binding]; other site 632348003868 Walker A motif; other site 632348003869 ATP binding site [chemical binding]; other site 632348003870 Walker B motif; other site 632348003871 inhibitor binding site; inhibition site 632348003872 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 632348003873 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 632348003874 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632348003875 HSP70 interaction site [polypeptide binding]; other site 632348003876 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 632348003877 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632348003878 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 632348003879 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632348003880 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 632348003881 trimer interface [polypeptide binding]; other site 632348003882 active site 632348003883 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 632348003884 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632348003885 Helix-turn-helix domains; Region: HTH; cl00088 632348003886 Helix-turn-helix domains; Region: HTH; cl00088 632348003887 hypothetical protein; Validated; Region: PRK07682 632348003888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632348003889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348003890 homodimer interface [polypeptide binding]; other site 632348003891 catalytic residue [active] 632348003892 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632348003893 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 632348003894 active site 632348003895 GTPase Era; Reviewed; Region: era; PRK00089 632348003896 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 632348003897 G1 box; other site 632348003898 GTP/Mg2+ binding site [chemical binding]; other site 632348003899 Switch I region; other site 632348003900 G2 box; other site 632348003901 Switch II region; other site 632348003902 G3 box; other site 632348003903 G4 box; other site 632348003904 G5 box; other site 632348003905 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 632348003906 Recombination protein O N terminal; Region: RecO_N; cl15812 632348003907 DNA repair protein RecO; Region: reco; TIGR00613 632348003908 Recombination protein O C terminal; Region: RecO_C; pfam02565 632348003909 glycyl-tRNA synthetase; Provisional; Region: PRK04173 632348003910 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 632348003911 dimer interface [polypeptide binding]; other site 632348003912 motif 1; other site 632348003913 active site 632348003914 motif 2; other site 632348003915 motif 3; other site 632348003916 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 632348003917 anticodon binding site; other site 632348003918 pyruvate phosphate dikinase; Provisional; Region: PRK09279 632348003919 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 632348003920 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 632348003921 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 632348003922 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 632348003923 Predicted transcriptional regulator [Transcription]; Region: COG3388 632348003924 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 632348003925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348003926 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 632348003927 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 632348003928 bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962 632348003929 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 632348003930 substrate binding site [chemical binding]; other site 632348003931 hinge regions; other site 632348003932 ADP binding site [chemical binding]; other site 632348003933 catalytic site [active] 632348003934 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 632348003935 substrate binding site [chemical binding]; other site 632348003936 dimer interface [polypeptide binding]; other site 632348003937 catalytic triad [active] 632348003938 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 632348003939 Sulfatase; Region: Sulfatase; cl10460 632348003940 enolase; Provisional; Region: eno; PRK00077 632348003941 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 632348003942 dimer interface [polypeptide binding]; other site 632348003943 metal binding site [ion binding]; metal-binding site 632348003944 substrate binding pocket [chemical binding]; other site 632348003945 Glucuronate isomerase; Region: UxaC; cl00829 632348003946 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 632348003947 putative active site [active] 632348003948 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 632348003949 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632348003950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632348003951 active site 632348003952 DNA binding site [nucleotide binding] 632348003953 Int/Topo IB signature motif; other site 632348003954 Uncharacterized conserved protein [Function unknown]; Region: COG1751 632348003955 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 632348003956 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 632348003957 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 632348003958 putative ligand binding site [chemical binding]; other site 632348003959 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 632348003960 TM-ABC transporter signature motif; other site 632348003961 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 632348003962 TM-ABC transporter signature motif; other site 632348003963 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 632348003964 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 632348003965 Walker A/P-loop; other site 632348003966 ATP binding site [chemical binding]; other site 632348003967 Q-loop/lid; other site 632348003968 ABC transporter signature motif; other site 632348003969 Walker B; other site 632348003970 D-loop; other site 632348003971 H-loop/switch region; other site 632348003972 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 632348003973 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 632348003974 Walker A/P-loop; other site 632348003975 ATP binding site [chemical binding]; other site 632348003976 Q-loop/lid; other site 632348003977 ABC transporter signature motif; other site 632348003978 Walker B; other site 632348003979 D-loop; other site 632348003980 H-loop/switch region; other site 632348003981 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 632348003982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348003983 Walker A/P-loop; other site 632348003984 ATP binding site [chemical binding]; other site 632348003985 Q-loop/lid; other site 632348003986 ABC transporter signature motif; other site 632348003987 Walker B; other site 632348003988 D-loop; other site 632348003989 H-loop/switch region; other site 632348003990 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 632348003991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348003992 active site 632348003993 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632348003994 catalytic core [active] 632348003995 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 632348003996 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 632348003997 heterodimer interface [polypeptide binding]; other site 632348003998 active site 632348003999 FMN binding site [chemical binding]; other site 632348004000 homodimer interface [polypeptide binding]; other site 632348004001 substrate binding site [chemical binding]; other site 632348004002 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 632348004003 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 632348004004 FAD binding pocket [chemical binding]; other site 632348004005 FAD binding motif [chemical binding]; other site 632348004006 phosphate binding motif [ion binding]; other site 632348004007 beta-alpha-beta structure motif; other site 632348004008 NAD binding pocket [chemical binding]; other site 632348004009 Iron coordination center [ion binding]; other site 632348004010 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 632348004011 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632348004012 ATP-grasp domain; Region: ATP-grasp_4; cl03087 632348004013 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 632348004014 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632348004015 ATP-grasp domain; Region: ATP-grasp_4; cl03087 632348004016 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 632348004017 IMP binding site; other site 632348004018 dimer interface [polypeptide binding]; other site 632348004019 interdomain contacts; other site 632348004020 partial ornithine binding site; other site 632348004021 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 632348004022 active site 632348004023 dimer interface [polypeptide binding]; other site 632348004024 dihydroorotase; Validated; Region: pyrC; PRK09357 632348004025 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 632348004026 active site 632348004027 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 632348004028 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 632348004029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004030 uracil transporter; Provisional; Region: PRK10720 632348004031 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 632348004032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348004033 active site 632348004034 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 632348004035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632348004036 RNA binding surface [nucleotide binding]; other site 632348004037 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 632348004038 active site 632348004039 lipoprotein signal peptidase; Provisional; Region: PRK14787 632348004040 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 632348004041 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632348004042 metal ion-dependent adhesion site (MIDAS); other site 632348004043 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 632348004044 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632348004045 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 632348004046 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 632348004047 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 632348004048 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632348004049 Helix-turn-helix domains; Region: HTH; cl00088 632348004050 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 632348004051 active site 632348004052 dimer interface [polypeptide binding]; other site 632348004053 metal binding site [ion binding]; metal-binding site 632348004054 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 632348004055 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 632348004056 HIGH motif; other site 632348004057 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632348004058 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 632348004059 active site 632348004060 KMSKS motif; other site 632348004061 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 632348004062 tRNA binding surface [nucleotide binding]; other site 632348004063 anticodon binding site; other site 632348004064 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 632348004065 DivIVA protein; Region: DivIVA; pfam05103 632348004066 DivIVA domain; Region: DivI1A_domain; TIGR03544 632348004067 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 632348004068 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632348004069 RNA binding surface [nucleotide binding]; other site 632348004070 YGGT family; Region: YGGT; cl00508 632348004071 Protein of unknown function (DUF552); Region: DUF552; cl00775 632348004072 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 632348004073 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632348004074 catalytic residue [active] 632348004075 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 632348004076 PHP-associated; Region: PHP_C; pfam13263 632348004077 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 632348004078 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 632348004079 dimer interface [polypeptide binding]; other site 632348004080 ADP-ribose binding site [chemical binding]; other site 632348004081 active site 632348004082 nudix motif; other site 632348004083 metal binding site [ion binding]; metal-binding site 632348004084 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 632348004085 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 632348004086 RNA/DNA hybrid binding site [nucleotide binding]; other site 632348004087 active site 632348004088 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 632348004089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004090 stage V sporulation protein B; Region: spore_V_B; TIGR02900 632348004091 MatE; Region: MatE; cl10513 632348004092 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 632348004093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348004094 active site 632348004095 phosphorylation site [posttranslational modification] 632348004096 intermolecular recognition site; other site 632348004097 dimerization interface [polypeptide binding]; other site 632348004098 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 632348004099 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 632348004100 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 632348004101 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 632348004102 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 632348004103 Walker A/P-loop; other site 632348004104 ATP binding site [chemical binding]; other site 632348004105 Q-loop/lid; other site 632348004106 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 632348004107 Q-loop/lid; other site 632348004108 ABC transporter signature motif; other site 632348004109 Walker B; other site 632348004110 D-loop; other site 632348004111 H-loop/switch region; other site 632348004112 arginine repressor; Provisional; Region: argR; PRK00441 632348004113 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 632348004114 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 632348004115 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 632348004116 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 632348004117 nucleotide binding site/active site [active] 632348004118 HIT family signature motif; other site 632348004119 catalytic residue [active] 632348004120 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 632348004121 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 632348004122 motif 1; other site 632348004123 active site 632348004124 motif 2; other site 632348004125 motif 3; other site 632348004126 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 632348004127 DHHA1 domain; Region: DHHA1; pfam02272 632348004128 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 632348004129 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 632348004130 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 632348004131 LytB protein; Region: LYTB; cl00507 632348004132 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 632348004133 RNA binding site [nucleotide binding]; other site 632348004134 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632348004135 RNA binding site [nucleotide binding]; other site 632348004136 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632348004137 RNA binding site [nucleotide binding]; other site 632348004138 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632348004139 putative acyl-acceptor binding pocket; other site 632348004140 cytidylate kinase; Provisional; Region: cmk; PRK00023 632348004141 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 632348004142 CMP-binding site; other site 632348004143 The sites determining sugar specificity; other site 632348004144 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 632348004145 homotrimer interaction site [polypeptide binding]; other site 632348004146 active site 632348004147 HutP; Region: HutP; cl07944 632348004148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632348004149 catalytic core [active] 632348004150 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 632348004151 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 632348004152 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 632348004153 putative active site [active] 632348004154 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 632348004155 oxaloacetate decarboxylase; Provisional; Region: PRK12331 632348004156 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 632348004157 active site 632348004158 catalytic residues [active] 632348004159 metal binding site [ion binding]; metal-binding site 632348004160 homodimer binding site [polypeptide binding]; other site 632348004161 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 632348004162 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632348004163 carboxyltransferase (CT) interaction site; other site 632348004164 biotinylation site [posttranslational modification]; other site 632348004165 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 632348004166 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 632348004167 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 632348004168 Arginase family; Region: Arginase; cl00306 632348004169 spermidine synthase; Provisional; Region: PRK00811 632348004170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348004171 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 632348004172 Mg++ binding site [ion binding]; other site 632348004173 putative catalytic motif [active] 632348004174 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632348004175 active site 632348004176 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 632348004177 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 632348004178 Thiamine pyrophosphokinase; Region: TPK; cl08415 632348004179 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 632348004180 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 632348004181 active site 632348004182 dimer interfaces [polypeptide binding]; other site 632348004183 catalytic residues [active] 632348004184 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 632348004185 Septum formation topological specificity factor MinE; Region: MinE; cl00538 632348004186 septum site-determining protein MinD; Region: minD_bact; TIGR01968 632348004187 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 632348004188 P-loop; other site 632348004189 ADP binding residues [chemical binding]; other site 632348004190 Switch I; other site 632348004191 Switch II; other site 632348004192 septum formation inhibitor; Reviewed; Region: minC; PRK00513 632348004193 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 632348004194 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 632348004195 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632348004196 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 632348004197 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632348004198 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 632348004199 rod shape-determining protein MreC; Provisional; Region: PRK13922 632348004200 rod shape-determining protein MreC; Region: MreC; pfam04085 632348004201 rod shape-determining protein MreB; Provisional; Region: PRK13927 632348004202 Cell division protein FtsA; Region: FtsA; cl11496 632348004203 Maf-like protein; Region: Maf; pfam02545 632348004204 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 632348004205 active site 632348004206 dimer interface [polypeptide binding]; other site 632348004207 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 632348004208 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632348004209 catalytic loop [active] 632348004210 iron binding site [ion binding]; other site 632348004211 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 632348004212 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 632348004213 4Fe-4S binding domain; Region: Fer4; cl02805 632348004214 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 632348004215 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 632348004216 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 632348004217 dimer interface [polypeptide binding]; other site 632348004218 [2Fe-2S] cluster binding site [ion binding]; other site 632348004219 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 632348004220 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 632348004221 SLBB domain; Region: SLBB; pfam10531 632348004222 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 632348004223 4Fe-4S binding domain; Region: Fer4; cl02805 632348004224 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632348004225 4Fe-4S binding domain; Region: Fer4; cl02805 632348004226 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 632348004227 dimer interface [polypeptide binding]; other site 632348004228 [2Fe-2S] cluster binding site [ion binding]; other site 632348004229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348004230 ATP binding site [chemical binding]; other site 632348004231 Mg2+ binding site [ion binding]; other site 632348004232 G-X-G motif; other site 632348004233 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 632348004234 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 632348004235 putative dimer interface [polypeptide binding]; other site 632348004236 [2Fe-2S] cluster binding site [ion binding]; other site 632348004237 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 632348004238 DRTGG domain; Region: DRTGG; cl12147 632348004239 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 632348004240 4Fe-4S binding domain; Region: Fer4; cl02805 632348004241 4Fe-4S binding domain; Region: Fer4; cl02805 632348004242 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 632348004243 Putative Fe-S cluster; Region: FeS; pfam04060 632348004244 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 632348004245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348004246 ATP binding site [chemical binding]; other site 632348004247 Mg2+ binding site [ion binding]; other site 632348004248 G-X-G motif; other site 632348004249 DRTGG domain; Region: DRTGG; cl12147 632348004250 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 632348004251 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632348004252 RNA binding surface [nucleotide binding]; other site 632348004253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 632348004254 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 632348004255 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 632348004256 TPP-binding site; other site 632348004257 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632348004258 PYR/PP interface [polypeptide binding]; other site 632348004259 dimer interface [polypeptide binding]; other site 632348004260 TPP binding site [chemical binding]; other site 632348004261 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632348004262 Divergent PAP2 family; Region: DUF212; cl00855 632348004263 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 632348004264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348004265 Family description; Region: UvrD_C_2; cl15862 632348004266 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 632348004267 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 632348004268 putative tRNA-binding site [nucleotide binding]; other site 632348004269 B3/4 domain; Region: B3_4; cl11458 632348004270 tRNA synthetase B5 domain; Region: B5; cl08394 632348004271 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 632348004272 dimer interface [polypeptide binding]; other site 632348004273 motif 1; other site 632348004274 motif 3; other site 632348004275 motif 2; other site 632348004276 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 632348004277 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 632348004278 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 632348004279 dimer interface [polypeptide binding]; other site 632348004280 motif 1; other site 632348004281 active site 632348004282 motif 2; other site 632348004283 motif 3; other site 632348004284 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 632348004285 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632348004286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348004287 FeS/SAM binding site; other site 632348004288 TRAM domain; Region: TRAM; cl01282 632348004289 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 632348004290 regulatory protein interface [polypeptide binding]; other site 632348004291 regulatory phosphorylation site [posttranslational modification]; other site 632348004292 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 632348004293 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 632348004294 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 632348004295 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 632348004296 Tetramer interface [polypeptide binding]; other site 632348004297 active site 632348004298 FMN-binding site [chemical binding]; other site 632348004299 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 632348004300 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348004301 Beta-Casp domain; Region: Beta-Casp; cl12567 632348004302 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632348004303 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 632348004304 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 632348004305 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 632348004306 active site 632348004307 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 632348004308 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 632348004309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348004310 Zn2+ binding site [ion binding]; other site 632348004311 Mg2+ binding site [ion binding]; other site 632348004312 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 632348004313 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348004314 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 632348004315 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 632348004316 YabP family; Region: YabP; cl06766 632348004317 GatB domain; Region: GatB_Yqey; cl11497 632348004318 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 632348004319 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632348004320 active site 632348004321 pyruvate kinase; Provisional; Region: PRK06354 632348004322 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 632348004323 domain interfaces; other site 632348004324 active site 632348004325 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 632348004326 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 632348004327 active site 632348004328 ADP/pyrophosphate binding site [chemical binding]; other site 632348004329 dimerization interface [polypeptide binding]; other site 632348004330 allosteric effector site; other site 632348004331 fructose-1,6-bisphosphate binding site; other site 632348004332 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 632348004333 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 632348004334 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 632348004335 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 632348004336 generic binding surface II; other site 632348004337 generic binding surface I; other site 632348004338 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632348004339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348004340 Zn2+ binding site [ion binding]; other site 632348004341 Mg2+ binding site [ion binding]; other site 632348004342 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 632348004343 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 632348004344 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 632348004345 SLBB domain; Region: SLBB; pfam10531 632348004346 comEA protein; Region: comE; TIGR01259 632348004347 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 632348004348 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 632348004349 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 632348004350 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 632348004351 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 632348004352 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 632348004353 HIGH motif; other site 632348004354 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632348004355 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 632348004356 active site 632348004357 KMSKS motif; other site 632348004358 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 632348004359 tRNA binding surface [nucleotide binding]; other site 632348004360 Oligomerisation domain; Region: Oligomerisation; cl00519 632348004361 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 632348004362 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 632348004363 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348004364 Zn2+ binding site [ion binding]; other site 632348004365 Mg2+ binding site [ion binding]; other site 632348004366 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 632348004367 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 632348004368 active site 632348004369 (T/H)XGH motif; other site 632348004370 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 632348004371 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 632348004372 ANP binding site [chemical binding]; other site 632348004373 Substrate Binding Site II [chemical binding]; other site 632348004374 Substrate Binding Site I [chemical binding]; other site 632348004375 argininosuccinate lyase; Provisional; Region: PRK00855 632348004376 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 632348004377 active sites [active] 632348004378 tetramer interface [polypeptide binding]; other site 632348004379 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 632348004380 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 632348004381 5S rRNA interface [nucleotide binding]; other site 632348004382 CTC domain interface [polypeptide binding]; other site 632348004383 L16 interface [polypeptide binding]; other site 632348004384 Protein of unknown function, DUF624; Region: DUF624; cl02369 632348004385 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 632348004386 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 632348004387 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632348004388 O-Antigen ligase; Region: Wzy_C; cl04850 632348004389 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632348004390 putative trimer interface [polypeptide binding]; other site 632348004391 putative CoA binding site [chemical binding]; other site 632348004392 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 632348004393 putative trimer interface [polypeptide binding]; other site 632348004394 putative active site [active] 632348004395 putative substrate binding site [chemical binding]; other site 632348004396 putative CoA binding site [chemical binding]; other site 632348004397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632348004398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004399 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 632348004400 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 632348004401 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632348004402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004403 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 632348004404 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 632348004405 inhibitor-cofactor binding pocket; inhibition site 632348004406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348004407 catalytic residue [active] 632348004408 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348004409 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 632348004410 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 632348004411 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 632348004412 Ligand binding site [chemical binding]; other site 632348004413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632348004414 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 632348004415 FAD binding site [chemical binding]; other site 632348004416 homotetramer interface [polypeptide binding]; other site 632348004417 substrate binding pocket [chemical binding]; other site 632348004418 catalytic base [active] 632348004419 hypothetical protein; Provisional; Region: PRK13670 632348004420 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632348004421 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 632348004422 active site 632348004423 nucleophile elbow; other site 632348004424 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 632348004425 Plant ATP synthase F0; Region: YMF19; cl07975 632348004426 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 632348004427 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 632348004428 active site 632348004429 (T/H)XGH motif; other site 632348004430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348004431 S-adenosylmethionine binding site [chemical binding]; other site 632348004432 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632348004433 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 632348004434 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 632348004435 ssDNA binding site; other site 632348004436 generic binding surface II; other site 632348004437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632348004438 ATP binding site [chemical binding]; other site 632348004439 putative Mg++ binding site [ion binding]; other site 632348004440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348004441 nucleotide binding region [chemical binding]; other site 632348004442 ATP-binding site [chemical binding]; other site 632348004443 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 632348004444 DAK2 domain; Region: Dak2; cl03685 632348004445 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 632348004446 Asp23 family; Region: Asp23; cl00574 632348004447 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 632348004448 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 632348004449 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 632348004450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632348004451 RNA binding surface [nucleotide binding]; other site 632348004452 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 632348004453 active site 632348004454 uracil binding [chemical binding]; other site 632348004455 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 632348004456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 632348004457 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 632348004458 PUA domain; Region: PUA; cl00607 632348004459 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 632348004460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348004461 S-adenosylmethionine binding site [chemical binding]; other site 632348004462 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 632348004463 nudix motif; other site 632348004464 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 632348004465 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 632348004466 GTP binding site; other site 632348004467 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 632348004468 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 632348004469 putative [4Fe-4S] binding site [ion binding]; other site 632348004470 putative molybdopterin cofactor binding site [chemical binding]; other site 632348004471 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 632348004472 molybdopterin cofactor binding site; other site 632348004473 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 632348004474 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 632348004475 dimerization interface [polypeptide binding]; other site 632348004476 active site 632348004477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004478 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 632348004479 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632348004480 Quinolinate synthetase A protein; Region: NadA; cl00420 632348004481 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 632348004482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632348004483 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632348004484 active site 632348004485 catalytic tetrad [active] 632348004486 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632348004487 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632348004488 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 632348004489 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632348004490 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 632348004491 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 632348004492 ribosomal protein L20; Region: rpl20; CHL00068 632348004493 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 632348004494 23S rRNA binding site [nucleotide binding]; other site 632348004495 L21 binding site [polypeptide binding]; other site 632348004496 L13 binding site [polypeptide binding]; other site 632348004497 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 632348004498 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 632348004499 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 632348004500 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 632348004501 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 632348004502 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 632348004503 Ligand Binding Site [chemical binding]; other site 632348004504 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 632348004505 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632348004506 inhibitor-cofactor binding pocket; inhibition site 632348004507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348004508 catalytic residue [active] 632348004509 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 632348004510 dimer interface [polypeptide binding]; other site 632348004511 active site 632348004512 Schiff base residues; other site 632348004513 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 632348004514 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 632348004515 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 632348004516 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 632348004517 active site 632348004518 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 632348004519 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 632348004520 domain interfaces; other site 632348004521 active site 632348004522 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 632348004523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004524 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 632348004525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004526 NAD(P) binding pocket [chemical binding]; other site 632348004527 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 632348004528 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 632348004529 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 632348004530 CysD dimerization site [polypeptide binding]; other site 632348004531 G1 box; other site 632348004532 putative GEF interaction site [polypeptide binding]; other site 632348004533 GTP/Mg2+ binding site [chemical binding]; other site 632348004534 Switch I region; other site 632348004535 G2 box; other site 632348004536 G3 box; other site 632348004537 Switch II region; other site 632348004538 G4 box; other site 632348004539 G5 box; other site 632348004540 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 632348004541 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 632348004542 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 632348004543 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632348004544 Active Sites [active] 632348004545 Ferredoxin [Energy production and conversion]; Region: COG1146 632348004546 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632348004547 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 632348004548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004549 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632348004550 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 632348004551 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632348004552 homodimer interface [polypeptide binding]; other site 632348004553 substrate-cofactor binding pocket; other site 632348004554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348004555 catalytic residue [active] 632348004556 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 632348004557 CPxP motif; other site 632348004558 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 632348004559 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 632348004560 4Fe-4S binding domain; Region: Fer4; cl02805 632348004561 4Fe-4S binding domain; Region: Fer4; cl02805 632348004562 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 632348004563 MPN+ (JAMM) motif; other site 632348004564 Zinc-binding site [ion binding]; other site 632348004565 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 632348004566 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 632348004567 ATP binding site [chemical binding]; other site 632348004568 substrate interface [chemical binding]; other site 632348004569 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 632348004570 thiS-thiF/thiG interaction site; other site 632348004571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348004572 dimer interface [polypeptide binding]; other site 632348004573 conserved gate region; other site 632348004574 putative PBP binding loops; other site 632348004575 ABC-ATPase subunit interface; other site 632348004576 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 632348004577 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 632348004578 Walker A/P-loop; other site 632348004579 ATP binding site [chemical binding]; other site 632348004580 Q-loop/lid; other site 632348004581 ABC transporter signature motif; other site 632348004582 Walker B; other site 632348004583 D-loop; other site 632348004584 H-loop/switch region; other site 632348004585 NMT1-like family; Region: NMT1_2; cl15260 632348004586 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 632348004587 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 632348004588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348004589 putative substrate translocation pore; other site 632348004590 AIR carboxylase; Region: AIRC; cl00310 632348004591 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 632348004592 ATP-grasp domain; Region: ATP-grasp_4; cl03087 632348004593 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 632348004594 hybrid cluster protein; Provisional; Region: PRK05290 632348004595 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632348004596 ACS interaction site; other site 632348004597 CODH interaction site; other site 632348004598 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 632348004599 hybrid metal cluster; other site 632348004600 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 632348004601 4Fe-4S binding domain; Region: Fer4; cl02805 632348004602 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 632348004603 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 632348004604 ligand binding site [chemical binding]; other site 632348004605 flexible hinge region; other site 632348004606 Helix-turn-helix domains; Region: HTH; cl00088 632348004607 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 632348004608 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 632348004609 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 632348004610 P loop; other site 632348004611 GTP binding site [chemical binding]; other site 632348004612 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 632348004613 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 632348004614 Walker A/P-loop; other site 632348004615 ATP binding site [chemical binding]; other site 632348004616 Q-loop/lid; other site 632348004617 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 632348004618 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 632348004619 ABC transporter signature motif; other site 632348004620 Walker B; other site 632348004621 D-loop; other site 632348004622 H-loop/switch region; other site 632348004623 NlpC/P60 family; Region: NLPC_P60; cl11438 632348004624 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632348004625 dimer interface [polypeptide binding]; other site 632348004626 catalytic residue [active] 632348004627 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 632348004628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348004629 dimer interface [polypeptide binding]; other site 632348004630 conserved gate region; other site 632348004631 putative PBP binding loops; other site 632348004632 ABC-ATPase subunit interface; other site 632348004633 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 632348004634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348004635 dimer interface [polypeptide binding]; other site 632348004636 conserved gate region; other site 632348004637 putative PBP binding loops; other site 632348004638 ABC-ATPase subunit interface; other site 632348004639 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632348004640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348004641 dimerization interface [polypeptide binding]; other site 632348004642 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 632348004643 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348004644 FeS/SAM binding site; other site 632348004645 ribonuclease III; Reviewed; Region: rnc; PRK00102 632348004646 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 632348004647 dimerization interface [polypeptide binding]; other site 632348004648 active site 632348004649 metal binding site [ion binding]; metal-binding site 632348004650 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 632348004651 dsRNA binding site [nucleotide binding]; other site 632348004652 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 632348004653 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 632348004654 dimer interface [polypeptide binding]; other site 632348004655 active site 632348004656 Phosphopantetheine attachment site; Region: PP-binding; cl09936 632348004657 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 632348004658 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 632348004659 NAD(P) binding site [chemical binding]; other site 632348004660 homotetramer interface [polypeptide binding]; other site 632348004661 homodimer interface [polypeptide binding]; other site 632348004662 active site 632348004663 Acyl transferase domain; Region: Acyl_transf_1; cl08282 632348004664 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 632348004665 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 632348004666 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 632348004667 dimer interface [polypeptide binding]; other site 632348004668 active site 632348004669 CoA binding pocket [chemical binding]; other site 632348004670 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 632348004671 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 632348004672 Helix-turn-helix domains; Region: HTH; cl00088 632348004673 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 632348004674 active site 1 [active] 632348004675 active site 2 [active] 632348004676 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 632348004677 active site 632348004678 tetramer interface; other site 632348004679 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 632348004680 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 632348004681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004682 NAD(P) binding site [chemical binding]; other site 632348004683 active site 632348004684 recombination protein RecR; Reviewed; Region: recR; PRK00076 632348004685 RecR protein; Region: RecR; pfam02132 632348004686 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 632348004687 putative active site [active] 632348004688 putative metal-binding site [ion binding]; other site 632348004689 tetramer interface [polypeptide binding]; other site 632348004690 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 632348004691 exonuclease SbcC; Region: sbcc; TIGR00618 632348004692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348004693 Walker A/P-loop; other site 632348004694 ATP binding site [chemical binding]; other site 632348004695 exonuclease SbcC; Region: sbcc; TIGR00618 632348004696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348004697 ABC transporter signature motif; other site 632348004698 Walker B; other site 632348004699 D-loop; other site 632348004700 H-loop/switch region; other site 632348004701 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 632348004702 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 632348004703 active site 632348004704 metal binding site [ion binding]; metal-binding site 632348004705 DNA binding site [nucleotide binding] 632348004706 HerA helicase [Replication, recombination, and repair]; Region: COG0433 632348004707 Domain of unknown function DUF87; Region: DUF87; pfam01935 632348004708 NurA domain; Region: NurA; cl09134 632348004709 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 632348004710 homotrimer interaction site [polypeptide binding]; other site 632348004711 zinc binding site [ion binding]; other site 632348004712 CDP-binding sites; other site 632348004713 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 632348004714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004715 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 632348004716 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 632348004717 dihydrodipicolinate synthase; Region: dapA; TIGR00674 632348004718 dimer interface [polypeptide binding]; other site 632348004719 active site 632348004720 catalytic residue [active] 632348004721 dihydrodipicolinate reductase; Provisional; Region: PRK00048 632348004722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004723 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 632348004724 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 632348004725 putative allosteric regulatory site; other site 632348004726 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 632348004727 putative allosteric regulatory residue; other site 632348004728 reverse gyrase; Reviewed; Region: PRK09401 632348004729 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348004730 TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove; Region: TOPRIM_TopoIA_RevGyr; cd03361 632348004731 active site 632348004732 putative interdomain interaction site [polypeptide binding]; other site 632348004733 putative metal-binding site [ion binding]; other site 632348004734 putative nucleotide binding site [chemical binding]; other site 632348004735 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 632348004736 domain I; other site 632348004737 DNA binding groove [nucleotide binding] 632348004738 phosphate binding site [ion binding]; other site 632348004739 domain II; other site 632348004740 domain III; other site 632348004741 nucleotide binding site [chemical binding]; other site 632348004742 catalytic site [active] 632348004743 domain IV; other site 632348004744 Cache domain; Region: Cache_2; cl07034 632348004745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 632348004746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348004747 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348004748 dimer interface [polypeptide binding]; other site 632348004749 putative CheW interface [polypeptide binding]; other site 632348004750 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 632348004751 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 632348004752 tetramer interface [polypeptide binding]; other site 632348004753 active site 632348004754 aspartate aminotransferase; Provisional; Region: PRK05764 632348004755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632348004756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348004757 homodimer interface [polypeptide binding]; other site 632348004758 catalytic residue [active] 632348004759 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 632348004760 active site 632348004761 dimer interface [polypeptide binding]; other site 632348004762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348004763 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348004764 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 632348004765 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 632348004766 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632348004767 homodimer interface [polypeptide binding]; other site 632348004768 substrate-cofactor binding pocket; other site 632348004769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348004770 catalytic residue [active] 632348004771 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 632348004772 KWG Leptospira; Region: KWG; pfam07656 632348004773 KWG Leptospira; Region: KWG; pfam07656 632348004774 KWG Leptospira; Region: KWG; pfam07656 632348004775 KWG Leptospira; Region: KWG; pfam07656 632348004776 GTPase CgtA; Reviewed; Region: obgE; PRK12297 632348004777 GTP1/OBG; Region: GTP1_OBG; pfam01018 632348004778 Obg GTPase; Region: Obg; cd01898 632348004779 G1 box; other site 632348004780 GTP/Mg2+ binding site [chemical binding]; other site 632348004781 Switch I region; other site 632348004782 G2 box; other site 632348004783 G3 box; other site 632348004784 Switch II region; other site 632348004785 G4 box; other site 632348004786 G5 box; other site 632348004787 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 632348004788 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 632348004789 Protein of unknown function (DUF464); Region: DUF464; cl01080 632348004790 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 632348004791 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 632348004792 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 632348004793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348004794 Walker A motif; other site 632348004795 ATP binding site [chemical binding]; other site 632348004796 Walker B motif; other site 632348004797 arginine finger; other site 632348004798 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 632348004799 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 632348004800 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 632348004801 active site 632348004802 putative DNA-binding cleft [nucleotide binding]; other site 632348004803 dimer interface [polypeptide binding]; other site 632348004804 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 632348004805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632348004806 Coenzyme A binding pocket [chemical binding]; other site 632348004807 alpha-galactosidase; Provisional; Region: PRK15076 632348004808 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 632348004809 NAD binding site [chemical binding]; other site 632348004810 sugar binding site [chemical binding]; other site 632348004811 divalent metal binding site [ion binding]; other site 632348004812 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 632348004813 dimer interface [polypeptide binding]; other site 632348004814 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 632348004815 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 632348004816 Predicted transcriptional regulator [Transcription]; Region: COG4189 632348004817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632348004818 dimerization interface [polypeptide binding]; other site 632348004819 putative DNA binding site [nucleotide binding]; other site 632348004820 putative Zn2+ binding site [ion binding]; other site 632348004821 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 632348004822 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 632348004823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 632348004824 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 632348004825 VanW like protein; Region: VanW; pfam04294 632348004826 G5 domain; Region: G5; pfam07501 632348004827 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 632348004828 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632348004829 TPP-binding site [chemical binding]; other site 632348004830 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 632348004831 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632348004832 dimer interface [polypeptide binding]; other site 632348004833 PYR/PP interface [polypeptide binding]; other site 632348004834 TPP binding site [chemical binding]; other site 632348004835 substrate binding site [chemical binding]; other site 632348004836 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632348004837 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632348004838 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 632348004839 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 632348004840 dimerization interface [polypeptide binding]; other site 632348004841 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 632348004842 ATP binding site [chemical binding]; other site 632348004843 Hydrogenase formation hypA family; Region: HypD; cl12072 632348004844 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 632348004845 HupF/HypC family; Region: HupF_HypC; cl00394 632348004846 Acylphosphatase; Region: Acylphosphatase; cl00551 632348004847 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 632348004848 HypF finger; Region: zf-HYPF; pfam07503 632348004849 HypF finger; Region: zf-HYPF; pfam07503 632348004850 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 632348004851 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348004852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348004853 G4 box; other site 632348004854 G5 box; other site 632348004855 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 632348004856 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 632348004857 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 632348004858 4Fe-4S binding domain; Region: Fer4; cl02805 632348004859 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 632348004860 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 632348004861 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 632348004862 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 632348004863 NADH dehydrogenase; Region: NADHdh; cl00469 632348004864 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 632348004865 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 632348004866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348004867 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 632348004868 active site 632348004869 motif I; other site 632348004870 motif II; other site 632348004871 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 632348004872 AMIN domain; Region: AMIN; pfam11741 632348004873 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632348004874 active site 632348004875 metal binding site [ion binding]; metal-binding site 632348004876 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 632348004877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348004878 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 632348004879 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 632348004880 feedback inhibition sensing region; other site 632348004881 homohexameric interface [polypeptide binding]; other site 632348004882 nucleotide binding site [chemical binding]; other site 632348004883 N-acetyl-L-glutamate binding site [chemical binding]; other site 632348004884 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 632348004885 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 632348004886 Low molecular weight phosphatase family; Region: LMWPc; cd00115 632348004887 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 632348004888 active site 632348004889 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 632348004890 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 632348004891 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 632348004892 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 632348004893 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 632348004894 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 632348004895 ligand binding site [chemical binding]; other site 632348004896 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 632348004897 flagellar motor protein MotA; Validated; Region: PRK08124 632348004898 peptide chain release factor 1; Validated; Region: prfA; PRK00591 632348004899 RF-1 domain; Region: RF-1; cl02875 632348004900 RF-1 domain; Region: RF-1; cl02875 632348004901 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 632348004902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348004903 S-adenosylmethionine binding site [chemical binding]; other site 632348004904 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 632348004905 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 632348004906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348004907 putative substrate translocation pore; other site 632348004908 Protease prsW family; Region: PrsW-protease; cl15823 632348004909 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 632348004910 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 632348004911 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632348004912 minor groove reading motif; other site 632348004913 helix-hairpin-helix signature motif; other site 632348004914 substrate binding pocket [chemical binding]; other site 632348004915 active site 632348004916 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632348004917 active site 632348004918 metal binding site [ion binding]; metal-binding site 632348004919 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 632348004920 transcription termination factor Rho; Provisional; Region: PRK12608 632348004921 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632348004922 RNA binding site [nucleotide binding]; other site 632348004923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348004924 Walker A motif; other site 632348004925 ATP binding site [chemical binding]; other site 632348004926 Walker B motif; other site 632348004927 Malic enzyme, N-terminal domain; Region: malic; pfam00390 632348004928 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 632348004929 putative NAD(P) binding site [chemical binding]; other site 632348004930 recombination factor protein RarA; Reviewed; Region: PRK13342 632348004931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348004932 Walker A motif; other site 632348004933 ATP binding site [chemical binding]; other site 632348004934 Walker B motif; other site 632348004935 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 632348004936 arginine finger; other site 632348004937 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 632348004938 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 632348004939 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 632348004940 dimer interface [polypeptide binding]; other site 632348004941 active site 632348004942 glycine-pyridoxal phosphate binding site [chemical binding]; other site 632348004943 folate binding site [chemical binding]; other site 632348004944 Uncharacterized conserved protein [Function unknown]; Region: COG2966 632348004945 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 632348004946 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 632348004947 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 632348004948 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 632348004949 RNase E interface [polypeptide binding]; other site 632348004950 trimer interface [polypeptide binding]; other site 632348004951 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 632348004952 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 632348004953 RNase E interface [polypeptide binding]; other site 632348004954 trimer interface [polypeptide binding]; other site 632348004955 active site 632348004956 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 632348004957 putative nucleic acid binding region [nucleotide binding]; other site 632348004958 G-X-X-G motif; other site 632348004959 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 632348004960 RNA binding site [nucleotide binding]; other site 632348004961 domain interface; other site 632348004962 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 632348004963 16S/18S rRNA binding site [nucleotide binding]; other site 632348004964 S13e-L30e interaction site [polypeptide binding]; other site 632348004965 25S rRNA binding site [nucleotide binding]; other site 632348004966 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 632348004967 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 632348004968 active site 632348004969 Riboflavin kinase; Region: Flavokinase; cl03312 632348004970 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 632348004971 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 632348004972 RNA binding site [nucleotide binding]; other site 632348004973 active site 632348004974 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 632348004975 DHH family; Region: DHH; pfam01368 632348004976 DHHA1 domain; Region: DHHA1; pfam02272 632348004977 Ribosome-binding factor A; Region: RBFA; cl00542 632348004978 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 632348004979 translation initiation factor IF-2; Validated; Region: infB; PRK05306 632348004980 translation initiation factor IF-2; Region: IF-2; TIGR00487 632348004981 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 632348004982 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 632348004983 G1 box; other site 632348004984 putative GEF interaction site [polypeptide binding]; other site 632348004985 GTP/Mg2+ binding site [chemical binding]; other site 632348004986 Switch I region; other site 632348004987 G2 box; other site 632348004988 G3 box; other site 632348004989 Switch II region; other site 632348004990 G4 box; other site 632348004991 G5 box; other site 632348004992 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 632348004993 Translation-initiation factor 2; Region: IF-2; pfam11987 632348004994 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 632348004995 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 632348004996 putative RNA binding cleft [nucleotide binding]; other site 632348004997 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 632348004998 NusA N-terminal domain; Region: NusA_N; pfam08529 632348004999 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 632348005000 RNA binding site [nucleotide binding]; other site 632348005001 homodimer interface [polypeptide binding]; other site 632348005002 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 632348005003 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 632348005004 G-X-X-G motif; other site 632348005005 ribosome maturation protein RimP; Reviewed; Region: PRK00092 632348005006 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 632348005007 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 632348005008 Sm1 motif; other site 632348005009 D1 - D2 interaction site; other site 632348005010 D3 - B interaction site; other site 632348005011 Hfq - Hfq interaction site; other site 632348005012 RNA binding pocket [nucleotide binding]; other site 632348005013 Sm2 motif; other site 632348005014 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 632348005015 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 632348005016 substrate binding site [chemical binding]; other site 632348005017 hexamer interface [polypeptide binding]; other site 632348005018 metal binding site [ion binding]; metal-binding site 632348005019 GTPase RsgA; Reviewed; Region: PRK00098 632348005020 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 632348005021 RNA binding site [nucleotide binding]; other site 632348005022 homodimer interface [polypeptide binding]; other site 632348005023 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 632348005024 GTP/Mg2+ binding site [chemical binding]; other site 632348005025 G4 box; other site 632348005026 G5 box; other site 632348005027 G1 box; other site 632348005028 Switch I region; other site 632348005029 G2 box; other site 632348005030 G3 box; other site 632348005031 Switch II region; other site 632348005032 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632348005033 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632348005034 active site 632348005035 ATP binding site [chemical binding]; other site 632348005036 substrate binding site [chemical binding]; other site 632348005037 activation loop (A-loop); other site 632348005038 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632348005039 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632348005040 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632348005041 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632348005042 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 632348005043 Protein phosphatase 2C; Region: PP2C; pfam00481 632348005044 active site 632348005045 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 632348005046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348005047 FeS/SAM binding site; other site 632348005048 16S rRNA methyltransferase B; Provisional; Region: PRK14902 632348005049 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 632348005050 putative RNA binding site [nucleotide binding]; other site 632348005051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348005052 S-adenosylmethionine binding site [chemical binding]; other site 632348005053 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 632348005054 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 632348005055 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 632348005056 putative active site [active] 632348005057 substrate binding site [chemical binding]; other site 632348005058 putative cosubstrate binding site; other site 632348005059 catalytic site [active] 632348005060 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 632348005061 substrate binding site [chemical binding]; other site 632348005062 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 632348005063 active site 632348005064 catalytic residues [active] 632348005065 metal binding site [ion binding]; metal-binding site 632348005066 primosome assembly protein PriA; Validated; Region: PRK05580 632348005067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632348005068 ATP binding site [chemical binding]; other site 632348005069 putative Mg++ binding site [ion binding]; other site 632348005070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348005071 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 632348005072 Flavoprotein; Region: Flavoprotein; cl08021 632348005073 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 632348005074 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 632348005075 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 632348005076 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 632348005077 catalytic site [active] 632348005078 G-X2-G-X-G-K; other site 632348005079 Domain of unknown function (DUF370); Region: DUF370; cl00898 632348005080 hypothetical protein; Provisional; Region: PRK11820 632348005081 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 632348005082 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 632348005083 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 632348005084 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 632348005085 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 632348005086 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 632348005087 Protein of unknown function DUF89; Region: DUF89; cl15397 632348005088 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632348005089 putative active site [active] 632348005090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005091 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 632348005092 Protein of unknown function (DUF421); Region: DUF421; cl00990 632348005093 AMP-binding enzyme; Region: AMP-binding; cl15778 632348005094 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632348005095 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 632348005096 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 632348005097 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632348005098 dimer interface [polypeptide binding]; other site 632348005099 PYR/PP interface [polypeptide binding]; other site 632348005100 TPP binding site [chemical binding]; other site 632348005101 substrate binding site [chemical binding]; other site 632348005102 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 632348005103 TPP-binding site; other site 632348005104 4Fe-4S binding domain; Region: Fer4; cl02805 632348005105 stage V sporulation protein T; Region: spore_V_T; TIGR02851 632348005106 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 632348005107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632348005108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348005109 putative substrate translocation pore; other site 632348005110 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 632348005111 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 632348005112 substrate binding pocket [chemical binding]; other site 632348005113 chain length determination region; other site 632348005114 substrate-Mg2+ binding site; other site 632348005115 catalytic residues [active] 632348005116 aspartate-rich region 1; other site 632348005117 active site lid residues [active] 632348005118 aspartate-rich region 2; other site 632348005119 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 632348005120 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 632348005121 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 632348005122 generic binding surface II; other site 632348005123 generic binding surface I; other site 632348005124 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 632348005125 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 632348005126 Asp23 family; Region: Asp23; cl00574 632348005127 Asp23 family; Region: Asp23; cl00574 632348005128 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 632348005129 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 632348005130 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 632348005131 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 632348005132 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 632348005133 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 632348005134 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 632348005135 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 632348005136 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 632348005137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348005138 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 632348005139 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632348005140 putative active site [active] 632348005141 metal binding site [ion binding]; metal-binding site 632348005142 homodimer binding site [polypeptide binding]; other site 632348005143 phosphodiesterase; Provisional; Region: PRK12704 632348005144 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 632348005145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 632348005146 recombinase A; Provisional; Region: recA; PRK09354 632348005147 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 632348005148 hexamer interface [polypeptide binding]; other site 632348005149 Walker A motif; other site 632348005150 ATP binding site [chemical binding]; other site 632348005151 Walker B motif; other site 632348005152 competence damage-inducible protein A; Provisional; Region: PRK00549 632348005153 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 632348005154 putative MPT binding site; other site 632348005155 Competence-damaged protein; Region: CinA; cl00666 632348005156 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 632348005157 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 632348005158 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632348005159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348005160 FeS/SAM binding site; other site 632348005161 TRAM domain; Region: TRAM; cl01282 632348005162 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 632348005163 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 632348005164 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 632348005165 homodimer interface [polypeptide binding]; other site 632348005166 NADP binding site [chemical binding]; other site 632348005167 substrate binding site [chemical binding]; other site 632348005168 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 632348005169 hypothetical protein; Provisional; Region: PRK00955 632348005170 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 632348005171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348005172 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 632348005173 Flavoprotein; Region: Flavoprotein; cl08021 632348005174 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 632348005175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005176 NAD(P) binding pocket [chemical binding]; other site 632348005177 Restriction endonuclease; Region: Mrr_cat; cl00516 632348005178 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 632348005179 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 632348005180 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 632348005181 RNA/DNA hybrid binding site [nucleotide binding]; other site 632348005182 active site 632348005183 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 632348005184 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 632348005185 GTP/Mg2+ binding site [chemical binding]; other site 632348005186 G4 box; other site 632348005187 G5 box; other site 632348005188 G1 box; other site 632348005189 Switch I region; other site 632348005190 G2 box; other site 632348005191 G3 box; other site 632348005192 Switch II region; other site 632348005193 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 632348005194 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 632348005195 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 632348005196 RimM N-terminal domain; Region: RimM; pfam01782 632348005197 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 632348005198 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 632348005199 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 632348005200 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 632348005201 signal recognition particle protein; Provisional; Region: PRK10867 632348005202 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 632348005203 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 632348005204 P loop; other site 632348005205 GTP binding site [chemical binding]; other site 632348005206 Signal peptide binding domain; Region: SRP_SPB; pfam02978 632348005207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 632348005208 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 632348005209 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 632348005210 Walker A/P-loop; other site 632348005211 ATP binding site [chemical binding]; other site 632348005212 Q-loop/lid; other site 632348005213 ABC transporter signature motif; other site 632348005214 Walker B; other site 632348005215 D-loop; other site 632348005216 H-loop/switch region; other site 632348005217 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348005218 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632348005219 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348005220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348005221 DNA-binding site [nucleotide binding]; DNA binding site 632348005222 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632348005223 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005224 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632348005225 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632348005226 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005227 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005228 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632348005229 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005230 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005231 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632348005232 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005233 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632348005234 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005235 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632348005236 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005237 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632348005238 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 632348005239 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 632348005240 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632348005241 HIGH motif; other site 632348005242 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 632348005243 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632348005244 active site 632348005245 HIGH motif; other site 632348005246 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632348005247 active site 632348005248 KMSKS motif; other site 632348005249 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 632348005250 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 632348005251 NAD binding site [chemical binding]; other site 632348005252 homodimer interface [polypeptide binding]; other site 632348005253 active site 632348005254 substrate binding site [chemical binding]; other site 632348005255 galactokinase; Provisional; Region: PRK05322 632348005256 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 632348005257 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632348005258 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632348005259 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 632348005260 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 632348005261 dimer interface [polypeptide binding]; other site 632348005262 active site 632348005263 Sensory domain found in PocR; Region: PocR; pfam10114 632348005264 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 632348005265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348005266 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348005267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348005268 Protein of unknown function (DUF523); Region: DUF523; cl00733 632348005269 Predicted GTPase [General function prediction only]; Region: COG0218 632348005270 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 632348005271 G1 box; other site 632348005272 GTP/Mg2+ binding site [chemical binding]; other site 632348005273 Switch I region; other site 632348005274 G2 box; other site 632348005275 G3 box; other site 632348005276 Switch II region; other site 632348005277 G4 box; other site 632348005278 G5 box; other site 632348005279 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 632348005280 Found in ATP-dependent protease La (LON); Region: LON; smart00464 632348005281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348005282 Walker A motif; other site 632348005283 ATP binding site [chemical binding]; other site 632348005284 Walker B motif; other site 632348005285 arginine finger; other site 632348005286 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 632348005287 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 632348005288 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632348005289 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632348005290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632348005291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005292 Predicted dehydrogenase [General function prediction only]; Region: COG0579 632348005293 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 632348005294 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632348005295 1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181 632348005296 dimer interface [polypeptide binding]; other site 632348005297 active site 632348005298 metal binding site [ion binding]; metal-binding site 632348005299 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 632348005300 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 632348005301 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348005302 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348005303 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 632348005304 Walker A/P-loop; other site 632348005305 ATP binding site [chemical binding]; other site 632348005306 Q-loop/lid; other site 632348005307 ABC transporter signature motif; other site 632348005308 Walker B; other site 632348005309 D-loop; other site 632348005310 H-loop/switch region; other site 632348005311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348005312 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 632348005313 Walker A/P-loop; other site 632348005314 ATP binding site [chemical binding]; other site 632348005315 Q-loop/lid; other site 632348005316 ABC transporter signature motif; other site 632348005317 Walker B; other site 632348005318 D-loop; other site 632348005319 H-loop/switch region; other site 632348005320 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 632348005321 active site 632348005322 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 632348005323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348005324 FeS/SAM binding site; other site 632348005325 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 632348005326 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 632348005327 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 632348005328 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 632348005329 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 632348005330 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 632348005331 NlpC/P60 family; Region: NLPC_P60; cl11438 632348005332 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 632348005333 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 632348005334 active site 632348005335 HIGH motif; other site 632348005336 dimer interface [polypeptide binding]; other site 632348005337 KMSKS motif; other site 632348005338 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632348005339 RNA binding surface [nucleotide binding]; other site 632348005340 integral membrane protein MviN; Region: mviN; TIGR01695 632348005341 MatE; Region: MatE; cl10513 632348005342 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 632348005343 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 632348005344 active site 632348005345 putative substrate binding pocket [chemical binding]; other site 632348005346 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 632348005347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005348 oligomerization interface [polypeptide binding]; other site 632348005349 active site 632348005350 NAD+ binding site [chemical binding]; other site 632348005351 replicative DNA helicase; Region: DnaB; TIGR00665 632348005352 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 632348005353 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 632348005354 Walker A motif; other site 632348005355 ATP binding site [chemical binding]; other site 632348005356 Walker B motif; other site 632348005357 DNA binding loops [nucleotide binding] 632348005358 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 632348005359 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 632348005360 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 632348005361 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 632348005362 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 632348005363 DHH family; Region: DHH; pfam01368 632348005364 DHHA1 domain; Region: DHHA1; pfam02272 632348005365 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 632348005366 prephenate dehydratase; Provisional; Region: PRK11898 632348005367 Prephenate dehydratase; Region: PDT; pfam00800 632348005368 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 632348005369 putative L-Phe binding site [chemical binding]; other site 632348005370 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 632348005371 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 632348005372 TPP-binding site [chemical binding]; other site 632348005373 putative dimer interface [polypeptide binding]; other site 632348005374 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 632348005375 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632348005376 dimer interface [polypeptide binding]; other site 632348005377 PYR/PP interface [polypeptide binding]; other site 632348005378 TPP binding site [chemical binding]; other site 632348005379 substrate binding site [chemical binding]; other site 632348005380 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 632348005381 4Fe-4S binding domain; Region: Fer4; cl02805 632348005382 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 632348005383 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 632348005384 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 632348005385 seryl-tRNA synthetase; Provisional; Region: PRK05431 632348005386 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 632348005387 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 632348005388 dimer interface [polypeptide binding]; other site 632348005389 active site 632348005390 motif 1; other site 632348005391 motif 2; other site 632348005392 motif 3; other site 632348005393 Protein of unknown function DUF45; Region: DUF45; cl00636 632348005394 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632348005395 active site 632348005396 NTP binding site [chemical binding]; other site 632348005397 metal binding triad [ion binding]; metal-binding site 632348005398 antibiotic binding site [chemical binding]; other site 632348005399 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 632348005400 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 632348005401 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 632348005402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632348005403 Probable transposase; Region: OrfB_IS605; pfam01385 632348005404 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632348005405 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632348005406 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 632348005407 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632348005408 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 632348005409 Walker A/P-loop; other site 632348005410 ATP binding site [chemical binding]; other site 632348005411 Q-loop/lid; other site 632348005412 ABC transporter signature motif; other site 632348005413 Walker B; other site 632348005414 D-loop; other site 632348005415 H-loop/switch region; other site 632348005416 Cobalt transport protein; Region: CbiQ; cl00463 632348005417 PDGLE domain; Region: PDGLE; cl07986 632348005418 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 632348005419 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 632348005420 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632348005421 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348005422 mannonate dehydratase; Provisional; Region: PRK03906 632348005423 mannonate dehydratase; Region: uxuA; TIGR00695 632348005424 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 632348005425 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 632348005426 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 632348005427 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 632348005428 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 632348005429 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 632348005430 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632348005431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348005432 active site 632348005433 phosphorylation site [posttranslational modification] 632348005434 intermolecular recognition site; other site 632348005435 dimerization interface [polypeptide binding]; other site 632348005436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348005437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348005438 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632348005439 Histidine kinase; Region: His_kinase; pfam06580 632348005440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348005441 ATP binding site [chemical binding]; other site 632348005442 Mg2+ binding site [ion binding]; other site 632348005443 G-X-G motif; other site 632348005444 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348005445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348005446 dimer interface [polypeptide binding]; other site 632348005447 ABC-ATPase subunit interface; other site 632348005448 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348005449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348005450 dimer interface [polypeptide binding]; other site 632348005451 conserved gate region; other site 632348005452 ABC-ATPase subunit interface; other site 632348005453 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632348005454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348005455 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 632348005456 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348005457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348005458 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 632348005459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632348005460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348005461 homodimer interface [polypeptide binding]; other site 632348005462 catalytic residue [active] 632348005463 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 632348005464 NeuB family; Region: NeuB; cl00496 632348005465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005466 Prephenate dehydrogenase; Region: PDH; pfam02153 632348005467 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 632348005468 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 632348005469 hinge; other site 632348005470 active site 632348005471 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632348005472 Helix-turn-helix domains; Region: HTH; cl00088 632348005473 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 632348005474 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 632348005475 N- and C-terminal domain interface [polypeptide binding]; other site 632348005476 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 632348005477 active site 632348005478 catalytic site [active] 632348005479 metal binding site [ion binding]; metal-binding site 632348005480 ATP binding site [chemical binding]; other site 632348005481 carbohydrate binding site [chemical binding]; other site 632348005482 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 632348005483 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 632348005484 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 632348005485 active site 632348005486 metal binding site [ion binding]; metal-binding site 632348005487 homotetramer interface [polypeptide binding]; other site 632348005488 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 632348005489 active site 632348005490 dimerization interface [polypeptide binding]; other site 632348005491 ribonuclease PH; Reviewed; Region: rph; PRK00173 632348005492 Ribonuclease PH; Region: RNase_PH_bact; cd11362 632348005493 hexamer interface [polypeptide binding]; other site 632348005494 active site 632348005495 Sporulation and spore germination; Region: Germane; cl11253 632348005496 Sporulation and spore germination; Region: Germane; cl11253 632348005497 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 632348005498 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 632348005499 Mg++ binding site [ion binding]; other site 632348005500 putative catalytic motif [active] 632348005501 substrate binding site [chemical binding]; other site 632348005502 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 632348005503 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 632348005504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005505 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 632348005506 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 632348005507 MPT binding site; other site 632348005508 trimer interface [polypeptide binding]; other site 632348005509 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 632348005510 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 632348005511 trimer interface [polypeptide binding]; other site 632348005512 dimer interface [polypeptide binding]; other site 632348005513 putative active site [active] 632348005514 MOSC domain; Region: MOSC; pfam03473 632348005515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348005516 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632348005517 FeS/SAM binding site; other site 632348005518 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 632348005519 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 632348005520 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 632348005521 dimer interface [polypeptide binding]; other site 632348005522 putative functional site; other site 632348005523 putative MPT binding site; other site 632348005524 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 632348005525 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 632348005526 dimer interface [polypeptide binding]; other site 632348005527 putative functional site; other site 632348005528 putative MPT binding site; other site 632348005529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348005530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348005531 Walker A/P-loop; other site 632348005532 ATP binding site [chemical binding]; other site 632348005533 Q-loop/lid; other site 632348005534 ABC transporter signature motif; other site 632348005535 Walker B; other site 632348005536 D-loop; other site 632348005537 H-loop/switch region; other site 632348005538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348005539 dimer interface [polypeptide binding]; other site 632348005540 conserved gate region; other site 632348005541 putative PBP binding loops; other site 632348005542 ABC-ATPase subunit interface; other site 632348005543 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 632348005544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348005545 hypothetical protein; Provisional; Region: PRK08328 632348005546 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 632348005547 ATP binding site [chemical binding]; other site 632348005548 substrate interface [chemical binding]; other site 632348005549 Ubiquitin-like proteins; Region: UBQ; cl00155 632348005550 charged pocket; other site 632348005551 hydrophobic patch; other site 632348005552 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 632348005553 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 632348005554 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 632348005555 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 632348005556 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 632348005557 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 632348005558 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 632348005559 Transcriptional regulator; Region: Transcrip_reg; cl00361 632348005560 stage V sporulation protein B; Region: spore_V_B; TIGR02900 632348005561 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 632348005562 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 632348005563 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 632348005564 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 632348005565 active site 632348005566 Ap6A binding site [chemical binding]; other site 632348005567 nudix motif; other site 632348005568 metal binding site [ion binding]; metal-binding site 632348005569 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 632348005570 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 632348005571 HflX GTPase family; Region: HflX; cd01878 632348005572 G1 box; other site 632348005573 GTP/Mg2+ binding site [chemical binding]; other site 632348005574 Switch I region; other site 632348005575 G2 box; other site 632348005576 G3 box; other site 632348005577 Switch II region; other site 632348005578 G4 box; other site 632348005579 G5 box; other site 632348005580 elongation factor Tu; Reviewed; Region: PRK00049 632348005581 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 632348005582 G1 box; other site 632348005583 GEF interaction site [polypeptide binding]; other site 632348005584 GTP/Mg2+ binding site [chemical binding]; other site 632348005585 Switch I region; other site 632348005586 G2 box; other site 632348005587 G3 box; other site 632348005588 Switch II region; other site 632348005589 G4 box; other site 632348005590 G5 box; other site 632348005591 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 632348005592 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 632348005593 Antibiotic Binding Site [chemical binding]; other site 632348005594 elongation factor G; Reviewed; Region: PRK00007 632348005595 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 632348005596 G1 box; other site 632348005597 putative GEF interaction site [polypeptide binding]; other site 632348005598 GTP/Mg2+ binding site [chemical binding]; other site 632348005599 Switch I region; other site 632348005600 G2 box; other site 632348005601 G3 box; other site 632348005602 Switch II region; other site 632348005603 G4 box; other site 632348005604 G5 box; other site 632348005605 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 632348005606 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 632348005607 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 632348005608 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 632348005609 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 632348005610 S17 interaction site [polypeptide binding]; other site 632348005611 S8 interaction site; other site 632348005612 16S rRNA interaction site [nucleotide binding]; other site 632348005613 streptomycin interaction site [chemical binding]; other site 632348005614 23S rRNA interaction site [nucleotide binding]; other site 632348005615 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 632348005616 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 632348005617 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 632348005618 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 632348005619 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 632348005620 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 632348005621 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 632348005622 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 632348005623 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 632348005624 G-loop; other site 632348005625 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 632348005626 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 632348005627 DNA binding site [nucleotide binding] 632348005628 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 632348005629 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 632348005630 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 632348005631 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 632348005632 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 632348005633 RPB1 interaction site [polypeptide binding]; other site 632348005634 RPB10 interaction site [polypeptide binding]; other site 632348005635 RPB11 interaction site [polypeptide binding]; other site 632348005636 RPB3 interaction site [polypeptide binding]; other site 632348005637 RPB12 interaction site [polypeptide binding]; other site 632348005638 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 632348005639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348005640 active site 632348005641 phosphorylation site [posttranslational modification] 632348005642 intermolecular recognition site; other site 632348005643 CheB methylesterase; Region: CheB_methylest; pfam01339 632348005644 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 632348005645 active site 632348005646 metal binding site [ion binding]; metal-binding site 632348005647 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 632348005648 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 632348005649 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 632348005650 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 632348005651 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 632348005652 active site 632348005653 dimer interface [polypeptide binding]; other site 632348005654 motif 1; other site 632348005655 motif 2; other site 632348005656 motif 3; other site 632348005657 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 632348005658 anticodon binding site; other site 632348005659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632348005660 binding surface 632348005661 TPR motif; other site 632348005662 Tetratricopeptide repeat; Region: TPR_16; pfam13432 632348005663 TPR repeat; Region: TPR_11; pfam13414 632348005664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632348005665 binding surface 632348005666 TPR motif; other site 632348005667 Divergent AAA domain; Region: AAA_4; pfam04326 632348005668 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 632348005669 CHASE4 domain; Region: CHASE4; cl01308 632348005670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348005671 Zn2+ binding site [ion binding]; other site 632348005672 Mg2+ binding site [ion binding]; other site 632348005673 Peptidase family M23; Region: Peptidase_M23; pfam01551 632348005674 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 632348005675 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 632348005676 ScpA/B protein; Region: ScpA_ScpB; cl00598 632348005677 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 632348005678 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 632348005679 active site 632348005680 HIGH motif; other site 632348005681 dimer interface [polypeptide binding]; other site 632348005682 KMSKS motif; other site 632348005683 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 632348005684 active site 632348005685 putative substrate binding region [chemical binding]; other site 632348005686 diaminopimelate decarboxylase; Region: lysA; TIGR01048 632348005687 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 632348005688 active site 632348005689 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632348005690 substrate binding site [chemical binding]; other site 632348005691 catalytic residues [active] 632348005692 dimer interface [polypeptide binding]; other site 632348005693 AMP-binding domain protein; Validated; Region: PRK08315 632348005694 AMP-binding enzyme; Region: AMP-binding; cl15778 632348005695 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632348005696 sporulation sigma factor SigG; Reviewed; Region: PRK08215 632348005697 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348005698 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632348005699 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348005700 DNA binding residues [nucleotide binding] 632348005701 sporulation sigma factor SigE; Reviewed; Region: PRK08301 632348005702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348005703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348005704 DNA binding residues [nucleotide binding] 632348005705 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 632348005706 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 632348005707 cell division protein FtsZ; Validated; Region: PRK09330 632348005708 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 632348005709 nucleotide binding site [chemical binding]; other site 632348005710 SulA interaction site; other site 632348005711 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 632348005712 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 632348005713 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 632348005714 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 632348005715 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632348005716 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632348005717 hinge; other site 632348005718 active site 632348005719 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 632348005720 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 632348005721 active site 632348005722 homodimer interface [polypeptide binding]; other site 632348005723 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 632348005724 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 632348005725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632348005727 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632348005728 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 632348005729 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 632348005730 Mg++ binding site [ion binding]; other site 632348005731 putative catalytic motif [active] 632348005732 putative substrate binding site [chemical binding]; other site 632348005733 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632348005734 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 632348005735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632348005736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632348005737 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 632348005738 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632348005739 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632348005740 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632348005741 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 632348005742 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 632348005743 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632348005744 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 632348005745 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 632348005746 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 632348005747 Septum formation initiator; Region: DivIC; cl11433 632348005748 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 632348005749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005750 cell division protein MraZ; Reviewed; Region: PRK00326 632348005751 MraZ protein; Region: MraZ; pfam02381 632348005752 MraZ protein; Region: MraZ; pfam02381 632348005753 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 632348005754 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 632348005755 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632348005756 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632348005757 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632348005758 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 632348005759 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632348005760 active site 632348005761 NTP binding site [chemical binding]; other site 632348005762 metal binding triad [ion binding]; metal-binding site 632348005763 antibiotic binding site [chemical binding]; other site 632348005764 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 632348005765 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 632348005766 GatB domain; Region: GatB_Yqey; cl11497 632348005767 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632348005768 Amidase; Region: Amidase; cl11426 632348005769 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 632348005770 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348005771 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 632348005772 Walker A/P-loop; other site 632348005773 ATP binding site [chemical binding]; other site 632348005774 Q-loop/lid; other site 632348005775 ABC transporter signature motif; other site 632348005776 Walker B; other site 632348005777 D-loop; other site 632348005778 H-loop/switch region; other site 632348005779 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 632348005780 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 632348005781 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 632348005782 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 632348005783 dimerization interface [polypeptide binding]; other site 632348005784 domain crossover interface; other site 632348005785 redox-dependent activation switch; other site 632348005786 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 632348005787 DNA-binding site [nucleotide binding]; DNA binding site 632348005788 RNA-binding motif; other site 632348005789 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 632348005790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348005791 S-adenosylmethionine binding site [chemical binding]; other site 632348005792 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 632348005793 GTP-binding protein Der; Reviewed; Region: PRK00093 632348005794 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 632348005795 G1 box; other site 632348005796 GTP/Mg2+ binding site [chemical binding]; other site 632348005797 Switch I region; other site 632348005798 G2 box; other site 632348005799 Switch II region; other site 632348005800 G3 box; other site 632348005801 G4 box; other site 632348005802 G5 box; other site 632348005803 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 632348005804 G1 box; other site 632348005805 GTP/Mg2+ binding site [chemical binding]; other site 632348005806 Switch I region; other site 632348005807 G2 box; other site 632348005808 G3 box; other site 632348005809 Switch II region; other site 632348005810 G4 box; other site 632348005811 G5 box; other site 632348005812 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 632348005813 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632348005814 Protein of unknown function (DUF512); Region: DUF512; pfam04459 632348005815 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 632348005816 substrate binding pocket [chemical binding]; other site 632348005817 dimer interface [polypeptide binding]; other site 632348005818 inhibitor binding site; inhibition site 632348005819 Protein of unknown function (DUF402); Region: DUF402; cl00979 632348005820 sporulation sigma factor SigK; Reviewed; Region: PRK05803 632348005821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348005822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348005823 DNA binding residues [nucleotide binding] 632348005824 putative protease; Provisional; Region: PRK15452 632348005825 Peptidase family U32; Region: Peptidase_U32; cl03113 632348005826 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 632348005827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005828 YceG-like family; Region: YceG; pfam02618 632348005829 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 632348005830 dimerization interface [polypeptide binding]; other site 632348005831 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 632348005832 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 632348005833 G1 box; other site 632348005834 putative GEF interaction site [polypeptide binding]; other site 632348005835 GTP/Mg2+ binding site [chemical binding]; other site 632348005836 Switch I region; other site 632348005837 G2 box; other site 632348005838 G3 box; other site 632348005839 Switch II region; other site 632348005840 G4 box; other site 632348005841 G5 box; other site 632348005842 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 632348005843 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 632348005844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348005845 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632348005846 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348005847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348005848 dimer interface [polypeptide binding]; other site 632348005849 conserved gate region; other site 632348005850 putative PBP binding loops; other site 632348005851 ABC-ATPase subunit interface; other site 632348005852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348005853 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 632348005854 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 632348005855 active site 632348005856 catalytic site [active] 632348005857 metal binding site [ion binding]; metal-binding site 632348005858 dimer interface [polypeptide binding]; other site 632348005859 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 632348005860 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632348005861 active site 632348005862 metal binding site [ion binding]; metal-binding site 632348005863 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 632348005864 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 632348005865 active site 632348005866 metal binding site [ion binding]; metal-binding site 632348005867 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 632348005868 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 632348005869 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 632348005870 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 632348005871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348005872 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632348005873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348005874 DNA binding residues [nucleotide binding] 632348005875 DNA primase; Validated; Region: dnaG; PRK05667 632348005876 CHC2 zinc finger; Region: zf-CHC2; cl15369 632348005877 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 632348005878 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 632348005879 active site 632348005880 metal binding site [ion binding]; metal-binding site 632348005881 interdomain interaction site; other site 632348005882 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 632348005883 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 632348005884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348005885 Zn2+ binding site [ion binding]; other site 632348005886 Mg2+ binding site [ion binding]; other site 632348005887 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 632348005888 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 632348005889 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 632348005890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348005891 Walker A motif; other site 632348005892 ATP binding site [chemical binding]; other site 632348005893 Walker B motif; other site 632348005894 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 632348005895 Clp protease; Region: CLP_protease; pfam00574 632348005896 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 632348005897 oligomer interface [polypeptide binding]; other site 632348005898 active site residues [active] 632348005899 trigger factor; Provisional; Region: tig; PRK01490 632348005900 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 632348005901 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 632348005902 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 632348005903 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 632348005904 hexamer (dimer of trimers) interface [polypeptide binding]; other site 632348005905 substrate binding site [chemical binding]; other site 632348005906 trimer interface [polypeptide binding]; other site 632348005907 Mn binding site [ion binding]; other site 632348005908 L-rhamnose isomerase; Provisional; Region: PRK01076 632348005909 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 632348005910 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632348005911 Helix-turn-helix domains; Region: HTH; cl00088 632348005912 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 632348005913 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 632348005914 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 632348005915 tetramer interface [polypeptide binding]; other site 632348005916 TPP-binding site [chemical binding]; other site 632348005917 heterodimer interface [polypeptide binding]; other site 632348005918 phosphorylation loop region [posttranslational modification] 632348005919 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 632348005920 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 632348005921 alpha subunit interface [polypeptide binding]; other site 632348005922 TPP binding site [chemical binding]; other site 632348005923 heterodimer interface [polypeptide binding]; other site 632348005924 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632348005925 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 632348005926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632348005928 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632348005929 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 632348005930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632348005931 E3 interaction surface; other site 632348005932 lipoyl attachment site [posttranslational modification]; other site 632348005933 e3 binding domain; Region: E3_binding; pfam02817 632348005934 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 632348005935 lipoyl synthase; Provisional; Region: PRK05481 632348005936 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 632348005937 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 632348005938 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632348005939 putative NAD(P) binding site [chemical binding]; other site 632348005940 catalytic Zn binding site [ion binding]; other site 632348005941 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 632348005942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348005943 NAD(P) binding site [chemical binding]; other site 632348005944 active site 632348005945 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 632348005946 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 632348005947 intersubunit interface [polypeptide binding]; other site 632348005948 active site 632348005949 Zn2+ binding site [ion binding]; other site 632348005950 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 632348005951 intersubunit interface [polypeptide binding]; other site 632348005952 active site 632348005953 Zn2+ binding site [ion binding]; other site 632348005954 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 632348005955 intersubunit interface [polypeptide binding]; other site 632348005956 active site 632348005957 Zn2+ binding site [ion binding]; other site 632348005958 L-type amino acid transporter; Region: 2A0308; TIGR00911 632348005959 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632348005960 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 632348005961 Protein of unknown function (DUF964); Region: DUF964; cl01483 632348005962 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 632348005963 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 632348005964 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 632348005965 DHH family; Region: DHH; pfam01368 632348005966 DHHA1 domain; Region: DHHA1; pfam02272 632348005967 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 632348005968 S-adenosylmethionine synthetase; Validated; Region: PRK05250 632348005969 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 632348005970 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 632348005971 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 632348005972 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 632348005973 putative active site [active] 632348005974 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 632348005975 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 632348005976 Domain of unknown function (DUF377); Region: DUF377; pfam04041 632348005977 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 632348005978 active site 632348005979 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 632348005980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348005981 Walker A/P-loop; other site 632348005982 ATP binding site [chemical binding]; other site 632348005983 Q-loop/lid; other site 632348005984 ABC transporter signature motif; other site 632348005985 Walker B; other site 632348005986 D-loop; other site 632348005987 H-loop/switch region; other site 632348005988 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 632348005989 VanZ like family; Region: VanZ; cl01971 632348005990 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 632348005991 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632348005992 PYR/PP interface [polypeptide binding]; other site 632348005993 dimer interface [polypeptide binding]; other site 632348005994 TPP binding site [chemical binding]; other site 632348005995 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 632348005996 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632348005997 TPP-binding site [chemical binding]; other site 632348005998 dimer interface [polypeptide binding]; other site 632348005999 Dehydratase family; Region: ILVD_EDD; cl00340 632348006000 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 632348006001 homodimer interface [polypeptide binding]; other site 632348006002 substrate-cofactor binding pocket; other site 632348006003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348006004 catalytic residue [active] 632348006005 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 632348006006 metal binding site [ion binding]; metal-binding site 632348006007 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 632348006008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 632348006009 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 632348006010 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 632348006011 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 632348006012 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 632348006013 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 632348006014 dimer interface [polypeptide binding]; other site 632348006015 putative anticodon binding site; other site 632348006016 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 632348006017 motif 1; other site 632348006018 active site 632348006019 motif 2; other site 632348006020 motif 3; other site 632348006021 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 632348006022 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 632348006023 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 632348006024 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 632348006025 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 632348006026 MgtE intracellular N domain; Region: MgtE_N; cl15244 632348006027 FOG: CBS domain [General function prediction only]; Region: COG0517 632348006028 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 632348006029 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 632348006030 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 632348006031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348006032 catalytic residue [active] 632348006033 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 632348006034 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 632348006035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348006036 hypothetical protein; Provisional; Region: PRK08582 632348006037 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 632348006038 RNA binding site [nucleotide binding]; other site 632348006039 Septum formation initiator; Region: DivIC; cl11433 632348006040 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 632348006041 YabP family; Region: YabP; cl06766 632348006042 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632348006043 RNA binding surface [nucleotide binding]; other site 632348006044 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 632348006045 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 632348006046 IHF dimer interface [polypeptide binding]; other site 632348006047 IHF - DNA interface [nucleotide binding]; other site 632348006048 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 632348006049 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 632348006050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 632348006051 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 632348006052 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 632348006053 FAD binding pocket [chemical binding]; other site 632348006054 FAD binding motif [chemical binding]; other site 632348006055 phosphate binding motif [ion binding]; other site 632348006056 beta-alpha-beta structure motif; other site 632348006057 NAD binding pocket [chemical binding]; other site 632348006058 Iron coordination center [ion binding]; other site 632348006059 putative oxidoreductase; Provisional; Region: PRK12831 632348006060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348006061 glutamine synthetase, type I; Region: GlnA; TIGR00653 632348006062 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 632348006063 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632348006064 FtsH Extracellular; Region: FtsH_ext; pfam06480 632348006065 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 632348006066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348006067 Walker A motif; other site 632348006068 ATP binding site [chemical binding]; other site 632348006069 Walker B motif; other site 632348006070 arginine finger; other site 632348006071 Peptidase family M41; Region: Peptidase_M41; pfam01434 632348006072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348006073 active site 632348006074 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 632348006075 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 632348006076 Ligand Binding Site [chemical binding]; other site 632348006077 B3/4 domain; Region: B3_4; cl11458 632348006078 SurA N-terminal domain; Region: SurA_N_3; cl07813 632348006079 PPIC-type PPIASE domain; Region: Rotamase; cl08278 632348006080 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 632348006081 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 632348006082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632348006083 ATP binding site [chemical binding]; other site 632348006084 putative Mg++ binding site [ion binding]; other site 632348006085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348006086 nucleotide binding region [chemical binding]; other site 632348006087 ATP-binding site [chemical binding]; other site 632348006088 TRCF domain; Region: TRCF; cl04088 632348006089 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 632348006090 putative active site [active] 632348006091 catalytic residue [active] 632348006092 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 632348006093 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 632348006094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348006095 active site 632348006096 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 632348006097 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 632348006098 Substrate binding site; other site 632348006099 Mg++ binding site; other site 632348006100 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 632348006101 active site 632348006102 substrate binding site [chemical binding]; other site 632348006103 CoA binding site [chemical binding]; other site 632348006104 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 632348006105 catalytic motif [active] 632348006106 Zn binding site [ion binding]; other site 632348006107 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348006108 active site 632348006109 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 632348006110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348006111 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632348006112 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632348006113 hinge; other site 632348006114 active site 632348006115 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 632348006116 active site 632348006117 catalytic triad [active] 632348006118 dimer interface [polypeptide binding]; other site 632348006119 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 632348006120 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 632348006121 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348006122 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632348006123 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 632348006124 Protein export membrane protein; Region: SecD_SecF; cl14618 632348006125 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 632348006126 Protein export membrane protein; Region: SecD_SecF; cl14618 632348006127 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 632348006128 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 632348006129 trimer interface [polypeptide binding]; other site 632348006130 putative metal binding site [ion binding]; other site 632348006131 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 632348006132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348006133 FeS/SAM binding site; other site 632348006134 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 632348006135 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 632348006136 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 632348006137 hypothetical protein; Provisional; Region: PRK08185 632348006138 intersubunit interface [polypeptide binding]; other site 632348006139 active site 632348006140 zinc binding site [ion binding]; other site 632348006141 Na+ binding site [ion binding]; other site 632348006142 putative hydrolase; Validated; Region: PRK09248 632348006143 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 632348006144 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 632348006145 dimer interface [polypeptide binding]; other site 632348006146 active site 632348006147 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 632348006148 dimer interface [polypeptide binding]; other site 632348006149 active site 632348006150 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348006151 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348006152 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 632348006153 Helix-turn-helix domains; Region: HTH; cl00088 632348006154 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632348006155 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 632348006156 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348006157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348006158 dimer interface [polypeptide binding]; other site 632348006159 conserved gate region; other site 632348006160 putative PBP binding loops; other site 632348006161 ABC-ATPase subunit interface; other site 632348006162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348006163 dimer interface [polypeptide binding]; other site 632348006164 conserved gate region; other site 632348006165 putative PBP binding loops; other site 632348006166 ABC-ATPase subunit interface; other site 632348006167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348006168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348006169 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 632348006170 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632348006171 minor groove reading motif; other site 632348006172 helix-hairpin-helix signature motif; other site 632348006173 substrate binding pocket [chemical binding]; other site 632348006174 active site 632348006175 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 632348006176 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 632348006177 carbohydrate binding site [chemical binding]; other site 632348006178 pullulanase, type I; Region: pulA_typeI; TIGR02104 632348006179 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 632348006180 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 632348006181 Ca binding site [ion binding]; other site 632348006182 active site 632348006183 catalytic site [active] 632348006184 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 632348006185 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632348006186 S-layer homology domain; Region: SLH; pfam00395 632348006187 S-layer homology domain; Region: SLH; pfam00395 632348006188 S-layer homology domain; Region: SLH; pfam00395 632348006189 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 632348006190 sugar binding site [chemical binding]; other site 632348006191 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 632348006192 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 632348006193 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 632348006194 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348006195 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 632348006196 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348006197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348006198 dimer interface [polypeptide binding]; other site 632348006199 conserved gate region; other site 632348006200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348006201 ABC-ATPase subunit interface; other site 632348006202 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348006203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348006204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632348006205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348006206 dimerization interface [polypeptide binding]; other site 632348006207 Histidine kinase; Region: His_kinase; pfam06580 632348006208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348006209 ATP binding site [chemical binding]; other site 632348006210 Mg2+ binding site [ion binding]; other site 632348006211 G-X-G motif; other site 632348006212 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632348006213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348006214 active site 632348006215 phosphorylation site [posttranslational modification] 632348006216 intermolecular recognition site; other site 632348006217 dimerization interface [polypeptide binding]; other site 632348006218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348006219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348006220 Helix-turn-helix domains; Region: HTH; cl00088 632348006221 Arginase family; Region: Arginase; cl00306 632348006222 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 632348006223 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632348006224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348006225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632348006226 putative substrate translocation pore; other site 632348006227 Response regulator receiver domain; Region: Response_reg; pfam00072 632348006228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348006229 active site 632348006230 phosphorylation site [posttranslational modification] 632348006231 intermolecular recognition site; other site 632348006232 dimerization interface [polypeptide binding]; other site 632348006233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348006234 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632348006235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348006236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632348006237 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348006238 dimerization interface [polypeptide binding]; other site 632348006239 Histidine kinase; Region: His_kinase; pfam06580 632348006240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348006241 ATP binding site [chemical binding]; other site 632348006242 Mg2+ binding site [ion binding]; other site 632348006243 G-X-G motif; other site 632348006244 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348006245 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348006246 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348006247 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 632348006248 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348006249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348006250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348006251 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348006252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348006253 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348006254 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 632348006255 S-layer homology domain; Region: SLH; pfam00395 632348006256 S-layer homology domain; Region: SLH; pfam00395 632348006257 S-layer homology domain; Region: SLH; pfam00395 632348006258 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 632348006259 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 632348006260 dimer interface [polypeptide binding]; other site 632348006261 anticodon binding site; other site 632348006262 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 632348006263 homodimer interface [polypeptide binding]; other site 632348006264 motif 1; other site 632348006265 active site 632348006266 motif 2; other site 632348006267 GAD domain; Region: GAD; pfam02938 632348006268 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 632348006269 motif 3; other site 632348006270 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 632348006271 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 632348006272 dimer interface [polypeptide binding]; other site 632348006273 motif 1; other site 632348006274 active site 632348006275 motif 2; other site 632348006276 motif 3; other site 632348006277 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 632348006278 anticodon binding site; other site 632348006279 CrcB-like protein; Region: CRCB; cl09114 632348006280 CrcB-like protein; Region: CRCB; cl09114 632348006281 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 632348006282 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 632348006283 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 632348006284 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 632348006285 Cation efflux family; Region: Cation_efflux; cl00316 632348006286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 632348006287 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348006288 active site 632348006289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 632348006290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348006291 Response regulator receiver domain; Region: Response_reg; pfam00072 632348006292 active site 632348006293 phosphorylation site [posttranslational modification] 632348006294 intermolecular recognition site; other site 632348006295 dimerization interface [polypeptide binding]; other site 632348006296 Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: SerS; COG0172 632348006297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348006298 dimer interface [polypeptide binding]; other site 632348006299 putative CheW interface [polypeptide binding]; other site 632348006300 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 632348006301 putative binding surface; other site 632348006302 active site 632348006303 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632348006304 Response regulator receiver domain; Region: Response_reg; pfam00072 632348006305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348006306 active site 632348006307 phosphorylation site [posttranslational modification] 632348006308 intermolecular recognition site; other site 632348006309 dimerization interface [polypeptide binding]; other site 632348006310 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 632348006311 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 632348006312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348006313 S-adenosylmethionine binding site [chemical binding]; other site 632348006314 HEAT repeats; Region: HEAT_2; pfam13646 632348006315 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 632348006316 HEAT repeats; Region: HEAT_2; pfam13646 632348006317 protein binding surface [polypeptide binding]; other site 632348006318 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 632348006319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632348006320 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 632348006321 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 632348006322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348006323 active site 632348006324 phosphorylation site [posttranslational modification] 632348006325 intermolecular recognition site; other site 632348006326 dimerization interface [polypeptide binding]; other site 632348006327 CheB methylesterase; Region: CheB_methylest; pfam01339 632348006328 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 632348006329 putative CheA interaction surface; other site 632348006330 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348006331 dimer interface [polypeptide binding]; other site 632348006332 putative CheW interface [polypeptide binding]; other site 632348006333 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348006334 dimer interface [polypeptide binding]; other site 632348006335 putative CheW interface [polypeptide binding]; other site 632348006336 Putative cyclase; Region: Cyclase; cl00814 632348006337 prolyl-tRNA synthetase; Provisional; Region: PRK09194 632348006338 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 632348006339 dimer interface [polypeptide binding]; other site 632348006340 motif 1; other site 632348006341 active site 632348006342 motif 2; other site 632348006343 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 632348006344 putative deacylase active site [active] 632348006345 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 632348006346 active site 632348006347 motif 3; other site 632348006348 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 632348006349 anticodon binding site; other site 632348006350 Mechanosensitive ion channel; Region: MS_channel; pfam00924 632348006351 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 632348006352 catalytic triad [active] 632348006353 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632348006354 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 632348006355 ANTAR domain; Region: ANTAR; cl04297 632348006356 GAF domain; Region: GAF; cl15785 632348006357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632348006358 Zn2+ binding site [ion binding]; other site 632348006359 Mg2+ binding site [ion binding]; other site 632348006360 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 632348006361 N- and C-terminal domain interface [polypeptide binding]; other site 632348006362 D-xylulose kinase; Region: XylB; TIGR01312 632348006363 active site 632348006364 catalytic site [active] 632348006365 metal binding site [ion binding]; metal-binding site 632348006366 xylulose binding site [chemical binding]; other site 632348006367 putative ATP binding site [chemical binding]; other site 632348006368 homodimer interface [polypeptide binding]; other site 632348006369 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348006370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632348006371 DNA binding site [nucleotide binding] 632348006372 domain linker motif; other site 632348006373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632348006374 dimerization interface [polypeptide binding]; other site 632348006375 ligand binding site [chemical binding]; other site 632348006376 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 632348006377 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 632348006378 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 632348006379 catalytic motif [active] 632348006380 Zn binding site [ion binding]; other site 632348006381 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 632348006382 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 632348006383 Lumazine binding domain; Region: Lum_binding; pfam00677 632348006384 Lumazine binding domain; Region: Lum_binding; pfam00677 632348006385 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 632348006386 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 632348006387 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 632348006388 dimerization interface [polypeptide binding]; other site 632348006389 active site 632348006390 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 632348006391 homopentamer interface [polypeptide binding]; other site 632348006392 active site 632348006393 HEPN domain; Region: HEPN; cl00824 632348006394 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632348006395 active site 632348006396 NTP binding site [chemical binding]; other site 632348006397 metal binding triad [ion binding]; metal-binding site 632348006398 antibiotic binding site [chemical binding]; other site 632348006399 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 632348006400 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 632348006401 putative peptidoglycan binding site; other site 632348006402 Bacterial SH3 domain; Region: SH3_3; cl02551 632348006403 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 632348006404 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 632348006405 putative peptidoglycan binding site; other site 632348006406 hypothetical protein; Reviewed; Region: PRK00024 632348006407 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 632348006408 MPN+ (JAMM) motif; other site 632348006409 Zinc-binding site [ion binding]; other site 632348006410 glycogen branching enzyme; Provisional; Region: PRK12313 632348006411 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 632348006412 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 632348006413 active site 632348006414 catalytic site [active] 632348006415 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 632348006416 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 632348006417 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 632348006418 ligand binding site; other site 632348006419 oligomer interface; other site 632348006420 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 632348006421 dimer interface [polypeptide binding]; other site 632348006422 N-terminal domain interface [polypeptide binding]; other site 632348006423 sulfate 1 binding site; other site 632348006424 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 632348006425 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 632348006426 ligand binding site; other site 632348006427 oligomer interface; other site 632348006428 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 632348006429 dimer interface [polypeptide binding]; other site 632348006430 N-terminal domain interface [polypeptide binding]; other site 632348006431 sulfate 1 binding site; other site 632348006432 glycogen synthase; Provisional; Region: glgA; PRK00654 632348006433 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 632348006434 ADP-binding pocket [chemical binding]; other site 632348006435 homodimer interface [polypeptide binding]; other site 632348006436 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 632348006437 homodimer interface [polypeptide binding]; other site 632348006438 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 632348006439 active site pocket [active] 632348006440 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 632348006441 active site 632348006442 catalytic triad [active] 632348006443 oxyanion hole [active] 632348006444 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 632348006445 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 632348006446 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 632348006447 ATP cone domain; Region: ATP-cone; pfam03477 632348006448 Class III ribonucleotide reductase; Region: RNR_III; cd01675 632348006449 effector binding site; other site 632348006450 active site 632348006451 Zn binding site [ion binding]; other site 632348006452 glycine loop; other site 632348006453 4Fe-4S binding domain; Region: Fer4_5; pfam12801 632348006454 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632348006455 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 632348006456 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 632348006457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632348006458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632348006459 homodimer interface [polypeptide binding]; other site 632348006460 catalytic residue [active] 632348006461 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 632348006462 Type III pantothenate kinase; Region: Pan_kinase; cl09130 632348006463 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632348006464 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632348006465 active site 632348006466 ATP binding site [chemical binding]; other site 632348006467 substrate binding site [chemical binding]; other site 632348006468 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632348006469 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632348006470 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632348006471 substrate binding site [chemical binding]; other site 632348006472 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 632348006473 sensor protein ZraS; Provisional; Region: PRK10364 632348006474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348006475 ATP binding site [chemical binding]; other site 632348006476 Mg2+ binding site [ion binding]; other site 632348006477 G-X-G motif; other site 632348006478 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632348006479 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 632348006480 putative NAD(P) binding site [chemical binding]; other site 632348006481 catalytic Zn binding site [ion binding]; other site 632348006482 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 632348006483 active site 632348006484 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632348006485 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632348006486 G5 domain; Region: G5; pfam07501 632348006487 3D domain; Region: 3D; cl01439 632348006488 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 632348006489 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 632348006490 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 632348006491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632348006492 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632348006493 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632348006494 active site residue [active] 632348006495 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 632348006496 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 632348006497 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 632348006498 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 632348006499 active site 632348006500 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 632348006501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632348006502 metal binding site [ion binding]; metal-binding site 632348006503 active site 632348006504 I-site; other site 632348006505 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 632348006506 ATP-grasp domain; Region: ATP-grasp_4; cl03087 632348006507 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632348006508 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632348006509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348006510 DNA-binding site [nucleotide binding]; DNA binding site 632348006511 FCD domain; Region: FCD; cl11656 632348006512 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 632348006513 isocitrate dehydrogenase; Validated; Region: PRK06451 632348006514 aconitate hydratase; Validated; Region: PRK07229 632348006515 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 632348006516 substrate binding site [chemical binding]; other site 632348006517 ligand binding site [chemical binding]; other site 632348006518 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 632348006519 substrate binding site [chemical binding]; other site 632348006520 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 632348006521 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 632348006522 putative ligand binding site [chemical binding]; other site 632348006523 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 632348006524 active site 632348006525 catalytic residues [active] 632348006526 metal binding site [ion binding]; metal-binding site 632348006527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348006528 dimer interface [polypeptide binding]; other site 632348006529 conserved gate region; other site 632348006530 putative PBP binding loops; other site 632348006531 ABC-ATPase subunit interface; other site 632348006532 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632348006533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348006534 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 632348006535 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 632348006536 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 632348006537 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 632348006538 Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia. This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965 632348006539 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 632348006540 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 632348006541 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 632348006542 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632348006543 Nitrogen regulatory protein P-II; Region: P-II; cl00412 632348006544 Nitrogen regulatory protein P-II; Region: P-II; cl00412 632348006545 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632348006546 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 632348006547 nitrogenase iron protein; Region: nifH; TIGR01287 632348006548 Nucleotide-binding sites [chemical binding]; other site 632348006549 Walker A motif; other site 632348006550 Switch I region of nucleotide binding site; other site 632348006551 Fe4S4 binding sites [ion binding]; other site 632348006552 Switch II region of nucleotide binding site; other site 632348006553 Nitrogen regulatory protein P-II; Region: P-II; cl00412 632348006554 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632348006555 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 632348006556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 632348006557 Transposase; Region: DDE_Tnp_ISL3; pfam01610 632348006558 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 632348006559 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 632348006560 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 632348006561 active site 632348006562 catalytic residues [active] 632348006563 metal binding site [ion binding]; metal-binding site 632348006564 RmuC family; Region: RmuC; pfam02646 632348006565 PSP1 C-terminal conserved region; Region: PSP1; cl00770 632348006566 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 632348006567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348006568 Protein of unknown function (DUF327); Region: DUF327; cl00753 632348006569 Nitrogen regulatory protein P-II; Region: P-II; cl00412 632348006570 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 632348006571 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 632348006572 TMP-binding site; other site 632348006573 ATP-binding site [chemical binding]; other site 632348006574 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 632348006575 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632348006576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632348006577 catalytic residue [active] 632348006578 Fumarase C-terminus; Region: Fumerase_C; cl00795 632348006579 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 632348006580 4Fe-4S binding domain; Region: Fer4; cl02805 632348006581 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 632348006582 putative peptidoglycan binding site; other site 632348006583 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 632348006584 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 632348006585 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 632348006586 active site 632348006587 catalytic residues [active] 632348006588 metal binding site [ion binding]; metal-binding site 632348006589 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 632348006590 2-isopropylmalate synthase; Validated; Region: PRK00915 632348006591 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 632348006592 active site 632348006593 catalytic residues [active] 632348006594 metal binding site [ion binding]; metal-binding site 632348006595 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 632348006596 ketol-acid reductoisomerase; Provisional; Region: PRK05479 632348006597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348006598 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 632348006599 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 632348006600 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 632348006601 putative valine binding site [chemical binding]; other site 632348006602 dimer interface [polypeptide binding]; other site 632348006603 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 632348006604 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 632348006605 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632348006606 PYR/PP interface [polypeptide binding]; other site 632348006607 dimer interface [polypeptide binding]; other site 632348006608 TPP binding site [chemical binding]; other site 632348006609 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 632348006610 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632348006611 TPP-binding site [chemical binding]; other site 632348006612 dimer interface [polypeptide binding]; other site 632348006613 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632348006614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348006615 NAD(P) binding site [chemical binding]; other site 632348006616 active site 632348006617 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348006618 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 632348006619 active site 632348006620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632348006621 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 632348006622 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 632348006623 diiron binding motif [ion binding]; other site 632348006624 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 632348006625 Aspartase; Region: Aspartase; cd01357 632348006626 active sites [active] 632348006627 tetramer interface [polypeptide binding]; other site 632348006628 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 632348006629 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 632348006630 G1 box; other site 632348006631 GTP/Mg2+ binding site [chemical binding]; other site 632348006632 Switch I region; other site 632348006633 G2 box; other site 632348006634 Switch II region; other site 632348006635 G3 box; other site 632348006636 G4 box; other site 632348006637 G5 box; other site 632348006638 Protein of unknown function (DUF541); Region: SIMPL; cl01077 632348006639 Predicted acetyltransferase [General function prediction only]; Region: COG3393 632348006640 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 632348006641 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 632348006642 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 632348006643 catalytic site [active] 632348006644 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 632348006645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348006646 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348006647 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 632348006648 Walker A/P-loop; other site 632348006649 ATP binding site [chemical binding]; other site 632348006650 Q-loop/lid; other site 632348006651 ABC transporter signature motif; other site 632348006652 Walker B; other site 632348006653 D-loop; other site 632348006654 H-loop/switch region; other site 632348006655 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 632348006656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632348006657 active site 632348006658 catalytic tetrad [active] 632348006659 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632348006660 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 632348006661 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 632348006662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632348006663 ATP binding site [chemical binding]; other site 632348006664 putative Mg++ binding site [ion binding]; other site 632348006665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632348006666 nucleotide binding region [chemical binding]; other site 632348006667 ATP-binding site [chemical binding]; other site 632348006668 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 632348006669 SmpB-tmRNA interface; other site 632348006670 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 632348006671 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 632348006672 Bacterial sugar transferase; Region: Bac_transf; cl00939 632348006673 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632348006674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348006675 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 632348006676 Putative carbohydrate binding domain; Region: CBM_X; cl05621 632348006677 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 632348006678 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 632348006679 Putative carbohydrate binding domain; Region: CBM_X; cl05621 632348006680 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 632348006681 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 632348006682 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 632348006683 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 632348006684 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 632348006685 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 632348006686 active site 632348006687 Ca binding site [ion binding]; other site 632348006688 catalytic site [active] 632348006689 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 632348006690 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 632348006691 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 632348006692 DNA binding site [nucleotide binding] 632348006693 active site 632348006694 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 632348006695 TRAM domain; Region: TRAM; cl01282 632348006696 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 632348006697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 632348006698 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 632348006699 octamerization interface [polypeptide binding]; other site 632348006700 diferric-oxygen binding site [ion binding]; other site 632348006701 N-glycosyltransferase; Provisional; Region: PRK11204 632348006702 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 632348006703 DXD motif; other site 632348006704 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632348006705 HEAT repeats; Region: HEAT_2; pfam13646 632348006706 Response regulator receiver domain; Region: Response_reg; pfam00072 632348006707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348006708 active site 632348006709 phosphorylation site [posttranslational modification] 632348006710 intermolecular recognition site; other site 632348006711 dimerization interface [polypeptide binding]; other site 632348006712 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 632348006713 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 632348006714 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632348006715 pullulanase, type I; Region: pulA_typeI; TIGR02104 632348006716 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 632348006717 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 632348006718 Ca binding site [ion binding]; other site 632348006719 active site 632348006720 catalytic site [active] 632348006721 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632348006722 metal binding site [ion binding]; metal-binding site 632348006723 active site 632348006724 I-site; other site 632348006725 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632348006726 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 632348006727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632348006728 Coenzyme A binding pocket [chemical binding]; other site 632348006729 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 632348006730 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 632348006731 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 632348006732 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 632348006733 active site 632348006734 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 632348006735 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 632348006736 active site 632348006737 S-layer homology domain; Region: SLH; pfam00395 632348006738 S-layer homology domain; Region: SLH; pfam00395 632348006739 Bacterial Ig-like domain; Region: Big_5; cl01012 632348006740 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 632348006741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348006742 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632348006743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348006744 DNA binding residues [nucleotide binding] 632348006745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632348006746 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632348006747 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632348006748 anti sigma factor interaction site; other site 632348006749 regulatory phosphorylation site [posttranslational modification]; other site 632348006750 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 632348006751 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632348006752 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632348006753 DNA binding residues [nucleotide binding] 632348006754 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 632348006755 dipeptidase PepV; Reviewed; Region: PRK07318 632348006756 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 632348006757 active site 632348006758 metal binding site [ion binding]; metal-binding site 632348006759 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632348006760 active site 632348006761 metal binding site [ion binding]; metal-binding site 632348006762 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 632348006763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 632348006764 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 632348006765 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 632348006766 Domain of unknown function DUF20; Region: UPF0118; pfam01594 632348006767 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 632348006768 Peptidase family U32; Region: Peptidase_U32; cl03113 632348006769 Collagenase; Region: DUF3656; pfam12392 632348006770 Peptidase family U32; Region: Peptidase_U32; cl03113 632348006771 Sulfatase; Region: Sulfatase; cl10460 632348006772 Cell division protein ZapA; Region: ZapA; cl01146 632348006773 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 632348006774 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632348006775 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 632348006776 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632348006777 active site 632348006778 catalytic tetrad [active] 632348006779 Rubrerythrin [Energy production and conversion]; Region: COG1592 632348006780 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 632348006781 binuclear metal center [ion binding]; other site 632348006782 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 632348006783 iron binding site [ion binding]; other site 632348006784 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 632348006785 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 632348006786 Uncharacterized conserved protein [Function unknown]; Region: COG3461 632348006787 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 632348006788 catalytic residue [active] 632348006789 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348006790 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632348006791 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 632348006792 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632348006793 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632348006794 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 632348006795 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348006796 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632348006797 DNA binding site [nucleotide binding] 632348006798 domain linker motif; other site 632348006799 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632348006800 ligand binding site [chemical binding]; other site 632348006801 dimerization interface [polypeptide binding]; other site 632348006802 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348006803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348006804 dimer interface [polypeptide binding]; other site 632348006805 conserved gate region; other site 632348006806 putative PBP binding loops; other site 632348006807 ABC-ATPase subunit interface; other site 632348006808 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348006809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348006810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348006811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348006812 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 632348006813 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632348006814 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632348006815 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 632348006816 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 632348006817 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 632348006818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348006819 motif II; other site 632348006820 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 632348006821 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 632348006822 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 632348006823 Substrate binding site; other site 632348006824 Cupin domain; Region: Cupin_2; cl09118 632348006825 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 632348006826 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 632348006827 active site 632348006828 substrate-binding site [chemical binding]; other site 632348006829 metal-binding site [ion binding] 632348006830 GTP binding site [chemical binding]; other site 632348006831 DREV methyltransferase; Region: DREV; pfam05219 632348006832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632348006833 S-adenosylmethionine binding site [chemical binding]; other site 632348006834 Preprotein translocase subunit; Region: YajC; cl00806 632348006835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348006836 FeS/SAM binding site; other site 632348006837 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 632348006838 GtrA-like protein; Region: GtrA; cl00971 632348006839 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 632348006840 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 632348006841 Ligand binding site; other site 632348006842 Putative Catalytic site; other site 632348006843 DXD motif; other site 632348006844 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 632348006845 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 632348006846 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 632348006847 dimer interface [polypeptide binding]; other site 632348006848 substrate binding site [chemical binding]; other site 632348006849 ATP binding site [chemical binding]; other site 632348006850 ThiC family; Region: ThiC; cl08031 632348006851 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 632348006852 thiamine phosphate binding site [chemical binding]; other site 632348006853 active site 632348006854 pyrophosphate binding site [ion binding]; other site 632348006855 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 632348006856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348006857 ATP binding site [chemical binding]; other site 632348006858 substrate interface [chemical binding]; other site 632348006859 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 632348006860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348006861 FeS/SAM binding site; other site 632348006862 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 632348006863 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 632348006864 ThiS interaction site; other site 632348006865 putative active site [active] 632348006866 tetramer interface [polypeptide binding]; other site 632348006867 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 632348006868 thiS-thiF/thiG interaction site; other site 632348006869 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632348006870 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 632348006871 Predicted transcriptional regulators [Transcription]; Region: COG1725 632348006872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348006873 DNA-binding site [nucleotide binding]; DNA binding site 632348006874 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 632348006875 HPr kinase/phosphorylase; Provisional; Region: PRK05428 632348006876 DRTGG domain; Region: DRTGG; cl12147 632348006877 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 632348006878 Hpr binding site; other site 632348006879 active site 632348006880 homohexamer subunit interaction site [polypeptide binding]; other site 632348006881 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 632348006882 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 632348006883 GIY-YIG motif/motif A; other site 632348006884 active site 632348006885 catalytic site [active] 632348006886 putative DNA binding site [nucleotide binding]; other site 632348006887 metal binding site [ion binding]; metal-binding site 632348006888 UvrB/uvrC motif; Region: UVR; pfam02151 632348006889 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 632348006890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 632348006891 YbbR-like protein; Region: YbbR; pfam07949 632348006892 Uncharacterized conserved protein [Function unknown]; Region: COG1624 632348006893 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 632348006894 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 632348006895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348006896 FeS/SAM binding site; other site 632348006897 hypothetical protein; Provisional; Region: PRK03881 632348006898 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 632348006899 AMMECR1; Region: AMMECR1; cl00911 632348006900 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632348006901 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632348006902 DNA interaction; other site 632348006903 Metal-binding active site; metal-binding site 632348006904 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632348006905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348006906 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 632348006907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632348006908 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632348006909 DNA binding site [nucleotide binding] 632348006910 domain linker motif; other site 632348006911 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 632348006912 dimerization interface [polypeptide binding]; other site 632348006913 ligand binding site [chemical binding]; other site 632348006914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348006915 putative substrate translocation pore; other site 632348006916 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632348006917 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 632348006918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348006919 FeS/SAM binding site; other site 632348006920 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632348006921 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 632348006922 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 632348006923 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632348006924 Walker A/P-loop; other site 632348006925 ATP binding site [chemical binding]; other site 632348006926 Q-loop/lid; other site 632348006927 ABC transporter signature motif; other site 632348006928 Walker B; other site 632348006929 D-loop; other site 632348006930 H-loop/switch region; other site 632348006931 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 632348006932 putative active site [active] 632348006933 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632348006934 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348006935 Walker A/P-loop; other site 632348006936 ATP binding site [chemical binding]; other site 632348006937 Q-loop/lid; other site 632348006938 ABC transporter signature motif; other site 632348006939 Walker B; other site 632348006940 D-loop; other site 632348006941 H-loop/switch region; other site 632348006942 Guanylate-binding protein, C-terminal domain; Region: GBP_C; pfam02841 632348006943 ABC-2 type transporter; Region: ABC2_membrane; cl11417 632348006944 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 632348006945 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632348006946 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 632348006947 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 632348006948 putative active site [active] 632348006949 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348006950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348006951 Walker A/P-loop; other site 632348006952 ATP binding site [chemical binding]; other site 632348006953 Q-loop/lid; other site 632348006954 ABC transporter signature motif; other site 632348006955 Walker B; other site 632348006956 D-loop; other site 632348006957 H-loop/switch region; other site 632348006958 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 632348006959 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 632348006960 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 632348006961 FAD binding site [chemical binding]; other site 632348006962 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 632348006963 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 632348006964 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 632348006965 regulatory protein interface [polypeptide binding]; other site 632348006966 active site 632348006967 regulatory phosphorylation site [posttranslational modification]; other site 632348006968 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 632348006969 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 632348006970 Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048 632348006971 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 632348006972 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 632348006973 phosphate binding site [ion binding]; other site 632348006974 putative substrate binding pocket [chemical binding]; other site 632348006975 dimer interface [polypeptide binding]; other site 632348006976 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 632348006977 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 632348006978 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 632348006979 FAD binding domain; Region: FAD_binding_4; pfam01565 632348006980 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 632348006981 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 632348006982 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 632348006983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348006984 active site 632348006985 motif I; other site 632348006986 motif II; other site 632348006987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632348006988 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632348006989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632348006990 dimerization interface [polypeptide binding]; other site 632348006991 putative DNA binding site [nucleotide binding]; other site 632348006992 putative Zn2+ binding site [ion binding]; other site 632348006993 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632348006994 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 632348006995 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632348006996 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 632348006997 Bifunctional nuclease; Region: DNase-RNase; cl00553 632348006998 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 632348006999 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 632348007000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348007001 FeS/SAM binding site; other site 632348007002 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 632348007003 active site 632348007004 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 632348007005 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 632348007006 active site 632348007007 HIGH motif; other site 632348007008 KMSKS motif; other site 632348007009 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 632348007010 tRNA binding surface [nucleotide binding]; other site 632348007011 anticodon binding site; other site 632348007012 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 632348007013 dimer interface [polypeptide binding]; other site 632348007014 putative tRNA-binding site [nucleotide binding]; other site 632348007015 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 632348007016 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 632348007017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348007018 active site 632348007019 phosphorylation site [posttranslational modification] 632348007020 intermolecular recognition site; other site 632348007021 dimerization interface [polypeptide binding]; other site 632348007022 CheB methylesterase; Region: CheB_methylest; pfam01339 632348007023 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 632348007024 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 632348007025 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 632348007026 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 632348007027 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 632348007028 homodimer interaction site [polypeptide binding]; other site 632348007029 cofactor binding site; other site 632348007030 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632348007031 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632348007032 Walker A/P-loop; other site 632348007033 ATP binding site [chemical binding]; other site 632348007034 Q-loop/lid; other site 632348007035 ABC transporter signature motif; other site 632348007036 Walker B; other site 632348007037 D-loop; other site 632348007038 H-loop/switch region; other site 632348007039 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 632348007040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632348007041 dimer interface [polypeptide binding]; other site 632348007042 putative PBP binding regions; other site 632348007043 ABC-ATPase subunit interface; other site 632348007044 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632348007045 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 632348007046 putative metal binding site [ion binding]; other site 632348007047 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 632348007048 putative active site [active] 632348007049 TIGR02679 family protein; Region: TIGR02679 632348007050 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 632348007051 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 632348007052 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 632348007053 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 632348007054 TIGR02677 family protein; Region: TIGR02677 632348007055 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 632348007056 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 632348007057 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 632348007058 Stage II sporulation protein; Region: SpoIID; pfam08486 632348007059 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 632348007060 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 632348007061 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632348007062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348007063 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632348007064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348007065 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 632348007066 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 632348007067 Cation transport protein; Region: TrkH; cl10514 632348007068 VanZ like family; Region: VanZ; cl01971 632348007069 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348007070 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348007071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007072 Walker A/P-loop; other site 632348007073 ATP binding site [chemical binding]; other site 632348007074 Q-loop/lid; other site 632348007075 ABC transporter signature motif; other site 632348007076 Walker B; other site 632348007077 D-loop; other site 632348007078 H-loop/switch region; other site 632348007079 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348007080 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348007081 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 632348007082 Walker A/P-loop; other site 632348007083 ATP binding site [chemical binding]; other site 632348007084 Q-loop/lid; other site 632348007085 ABC transporter signature motif; other site 632348007086 Walker B; other site 632348007087 D-loop; other site 632348007088 H-loop/switch region; other site 632348007089 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 632348007090 Helix-turn-helix domains; Region: HTH; cl00088 632348007091 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348007092 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 632348007093 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 632348007094 active site 632348007095 Substrate binding site; other site 632348007096 Mg++ binding site; other site 632348007097 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632348007098 putative trimer interface [polypeptide binding]; other site 632348007099 putative CoA binding site [chemical binding]; other site 632348007100 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 632348007101 metal binding site [ion binding]; metal-binding site 632348007102 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632348007103 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632348007104 chloroplast Hsp70; Provisional; Region: PLN03184 632348007105 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 632348007106 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 632348007107 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 632348007108 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632348007109 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348007110 NAD synthetase; Provisional; Region: PRK13981 632348007111 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 632348007112 multimer interface [polypeptide binding]; other site 632348007113 active site 632348007114 catalytic triad [active] 632348007115 protein interface 1 [polypeptide binding]; other site 632348007116 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 632348007117 homodimer interface [polypeptide binding]; other site 632348007118 NAD binding pocket [chemical binding]; other site 632348007119 ATP binding pocket [chemical binding]; other site 632348007120 Mg binding site [ion binding]; other site 632348007121 active-site loop [active] 632348007122 SurA N-terminal domain; Region: SurA_N_3; cl07813 632348007123 stage II sporulation protein D; Region: spore_II_D; TIGR02870 632348007124 Stage II sporulation protein; Region: SpoIID; pfam08486 632348007125 stage II sporulation protein E; Region: spore_II_E; TIGR02865 632348007126 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 632348007127 phage shock protein A; Region: phageshock_pspA; TIGR02977 632348007128 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632348007129 putative active site [active] 632348007130 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 632348007131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348007132 NAD(P) binding site [chemical binding]; other site 632348007133 active site 632348007134 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 632348007135 catalytic center binding site [active] 632348007136 ATP binding site [chemical binding]; other site 632348007137 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 632348007138 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 632348007139 dihydropteroate synthase; Region: DHPS; TIGR01496 632348007140 substrate binding pocket [chemical binding]; other site 632348007141 dimer interface [polypeptide binding]; other site 632348007142 inhibitor binding site; inhibition site 632348007143 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 632348007144 Helix-turn-helix domains; Region: HTH; cl00088 632348007145 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 632348007146 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 632348007147 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632348007148 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632348007149 active site 632348007150 hinge; other site 632348007151 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632348007152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348007153 dimer interface [polypeptide binding]; other site 632348007154 putative CheW interface [polypeptide binding]; other site 632348007155 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348007156 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348007157 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 632348007158 Walker A/P-loop; other site 632348007159 ATP binding site [chemical binding]; other site 632348007160 Q-loop/lid; other site 632348007161 ABC transporter signature motif; other site 632348007162 Walker B; other site 632348007163 D-loop; other site 632348007164 H-loop/switch region; other site 632348007165 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348007166 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348007167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007168 Walker A/P-loop; other site 632348007169 ATP binding site [chemical binding]; other site 632348007170 Q-loop/lid; other site 632348007171 ABC transporter signature motif; other site 632348007172 Walker B; other site 632348007173 D-loop; other site 632348007174 H-loop/switch region; other site 632348007175 Helix-turn-helix domains; Region: HTH; cl00088 632348007176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632348007177 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 632348007178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348007179 FeS/SAM binding site; other site 632348007180 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 632348007181 Ligand Binding Site [chemical binding]; other site 632348007182 TIGR00269 family protein; Region: TIGR00269 632348007183 Ubiquitin-like proteins; Region: UBQ; cl00155 632348007184 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 632348007185 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 632348007186 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 632348007187 homotrimer interaction site [polypeptide binding]; other site 632348007188 putative active site [active] 632348007189 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 632348007190 Ligand Binding Site [chemical binding]; other site 632348007191 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 632348007192 putative peptidoglycan binding site; other site 632348007193 G5 domain; Region: G5; pfam07501 632348007194 Peptidase family M23; Region: Peptidase_M23; pfam01551 632348007195 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348007196 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348007197 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632348007198 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348007199 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 632348007200 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 632348007201 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348007202 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348007203 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 632348007204 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 632348007205 active site 632348007206 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632348007207 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 632348007208 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 632348007209 substrate binding site [chemical binding]; other site 632348007210 active site 632348007211 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 632348007212 metal binding site [ion binding]; metal-binding site 632348007213 ligand binding site [chemical binding]; other site 632348007214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348007215 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348007216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348007217 dimer interface [polypeptide binding]; other site 632348007218 conserved gate region; other site 632348007219 putative PBP binding loops; other site 632348007220 ABC-ATPase subunit interface; other site 632348007221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632348007222 Ubiquitin-activating enzyme e1 C-terminal domain; Region: UBA_e1_C; cl09615 632348007223 NHL repeat; Region: NHL; pfam01436 632348007224 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 632348007225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632348007226 binding surface 632348007227 Tetratricopeptide repeat; Region: TPR_16; pfam13432 632348007228 TPR motif; other site 632348007229 Yip1 domain; Region: Yip1; cl12048 632348007230 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632348007231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348007232 dimer interface [polypeptide binding]; other site 632348007233 conserved gate region; other site 632348007234 putative PBP binding loops; other site 632348007235 ABC-ATPase subunit interface; other site 632348007236 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632348007237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632348007238 dimer interface [polypeptide binding]; other site 632348007239 conserved gate region; other site 632348007240 putative PBP binding loops; other site 632348007241 ABC-ATPase subunit interface; other site 632348007242 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632348007243 putative metal binding site [ion binding]; other site 632348007244 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632348007245 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632348007246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348007247 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 632348007248 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 632348007249 Predicted methyltransferases [General function prediction only]; Region: COG0313 632348007250 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 632348007251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348007252 Response regulator receiver domain; Region: Response_reg; pfam00072 632348007253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348007254 active site 632348007255 phosphorylation site [posttranslational modification] 632348007256 intermolecular recognition site; other site 632348007257 dimerization interface [polypeptide binding]; other site 632348007258 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 632348007259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348007260 FeS/SAM binding site; other site 632348007261 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 632348007262 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 632348007263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 632348007264 active site 632348007265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632348007266 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 632348007267 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632348007268 DNA binding residues [nucleotide binding] 632348007269 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 632348007270 catalytic residues [active] 632348007271 catalytic nucleophile [active] 632348007272 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 632348007273 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 632348007274 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 632348007275 Ca binding site [ion binding]; other site 632348007276 active site 632348007277 catalytic site [active] 632348007278 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 632348007279 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632348007280 metal binding site 2 [ion binding]; metal-binding site 632348007281 putative DNA binding helix; other site 632348007282 metal binding site 1 [ion binding]; metal-binding site 632348007283 dimer interface [polypeptide binding]; other site 632348007284 structural Zn2+ binding site [ion binding]; other site 632348007285 Rubrerythrin [Energy production and conversion]; Region: COG1592 632348007286 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 632348007287 binuclear metal center [ion binding]; other site 632348007288 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 632348007289 iron binding site [ion binding]; other site 632348007290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348007291 Short C-terminal domain; Region: SHOCT; cl01373 632348007292 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 632348007293 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 632348007294 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 632348007295 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 632348007296 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 632348007297 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 632348007298 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 632348007299 dimerization domain swap beta strand [polypeptide binding]; other site 632348007300 regulatory protein interface [polypeptide binding]; other site 632348007301 active site 632348007302 regulatory phosphorylation site [posttranslational modification]; other site 632348007303 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 632348007304 active site 632348007305 P-loop; other site 632348007306 phosphorylation site [posttranslational modification] 632348007307 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 632348007308 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 632348007309 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 632348007310 active site 632348007311 phosphorylation site [posttranslational modification] 632348007312 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 632348007313 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 632348007314 putative substrate binding site [chemical binding]; other site 632348007315 putative ATP binding site [chemical binding]; other site 632348007316 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632348007317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632348007318 DNA-binding site [nucleotide binding]; DNA binding site 632348007319 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 632348007320 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 632348007321 homodimer interface [polypeptide binding]; other site 632348007322 active site 632348007323 catalytic site [active] 632348007324 maltose binding site 2 [chemical binding]; other site 632348007325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 632348007326 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 632348007327 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 632348007328 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 632348007329 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 632348007330 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 632348007331 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 632348007332 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 632348007333 CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cd09661 632348007334 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 632348007335 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 632348007336 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 632348007337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007338 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 632348007339 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 632348007340 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 632348007341 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 632348007342 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 632348007343 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 632348007344 NodB motif; other site 632348007345 putative active site [active] 632348007346 putative catalytic site [active] 632348007347 Zn binding site [ion binding]; other site 632348007348 SpoVG; Region: SpoVG; cl00915 632348007349 pur operon repressor; Provisional; Region: PRK09213 632348007350 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 632348007351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632348007352 active site 632348007353 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348007354 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348007355 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 632348007356 Walker A/P-loop; other site 632348007357 ATP binding site [chemical binding]; other site 632348007358 Q-loop/lid; other site 632348007359 ABC transporter signature motif; other site 632348007360 Walker B; other site 632348007361 D-loop; other site 632348007362 H-loop/switch region; other site 632348007363 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632348007364 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 632348007365 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007366 Walker A/P-loop; other site 632348007367 ATP binding site [chemical binding]; other site 632348007368 Q-loop/lid; other site 632348007369 ABC transporter signature motif; other site 632348007370 Walker B; other site 632348007371 D-loop; other site 632348007372 H-loop/switch region; other site 632348007373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632348007374 Helix-turn-helix domains; Region: HTH; cl00088 632348007375 Protein of unknown function (DUF554); Region: DUF554; cl00784 632348007376 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632348007377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007378 Walker A/P-loop; other site 632348007379 ATP binding site [chemical binding]; other site 632348007380 Q-loop/lid; other site 632348007381 ABC transporter signature motif; other site 632348007382 Walker B; other site 632348007383 D-loop; other site 632348007384 H-loop/switch region; other site 632348007385 ABC-2 type transporter; Region: ABC2_membrane; cl11417 632348007386 ABC-2 type transporter; Region: ABC2_membrane; cl11417 632348007387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632348007388 Histidine kinase; Region: HisKA_3; pfam07730 632348007389 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632348007390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348007391 active site 632348007392 phosphorylation site [posttranslational modification] 632348007393 intermolecular recognition site; other site 632348007394 dimerization interface [polypeptide binding]; other site 632348007395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632348007396 DNA binding residues [nucleotide binding] 632348007397 dimerization interface [polypeptide binding]; other site 632348007398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632348007399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632348007400 active site 632348007401 phosphorylation site [posttranslational modification] 632348007402 intermolecular recognition site; other site 632348007403 dimerization interface [polypeptide binding]; other site 632348007404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632348007405 DNA binding site [nucleotide binding] 632348007406 sensor kinase CusS; Provisional; Region: PRK09835 632348007407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 632348007408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632348007409 ATP binding site [chemical binding]; other site 632348007410 Mg2+ binding site [ion binding]; other site 632348007411 G-X-G motif; other site 632348007412 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632348007413 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 632348007414 Walker A/P-loop; other site 632348007415 ATP binding site [chemical binding]; other site 632348007416 Q-loop/lid; other site 632348007417 ABC transporter signature motif; other site 632348007418 Walker B; other site 632348007419 D-loop; other site 632348007420 H-loop/switch region; other site 632348007421 FtsX-like permease family; Region: FtsX; cl15850 632348007422 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 632348007423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632348007424 dimerization interface [polypeptide binding]; other site 632348007425 putative DNA binding site [nucleotide binding]; other site 632348007426 putative Zn2+ binding site [ion binding]; other site 632348007427 Predicted permease; Region: DUF318; pfam03773 632348007428 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 632348007429 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632348007430 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632348007431 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632348007432 DNA binding residues [nucleotide binding] 632348007433 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 632348007434 catalytic residues [active] 632348007435 catalytic nucleophile [active] 632348007436 Cupin domain; Region: Cupin_2; cl09118 632348007437 Helix-turn-helix domain; Region: HTH_18; pfam12833 632348007438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632348007439 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 632348007440 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 632348007441 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 632348007442 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632348007443 putative active site [active] 632348007444 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 632348007445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348007446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632348007447 putative substrate translocation pore; other site 632348007448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632348007449 biotin synthase; Provisional; Region: PRK07094 632348007450 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632348007451 FeS/SAM binding site; other site 632348007452 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 632348007453 Transglycosylase; Region: Transgly; cl07896 632348007454 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 632348007455 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 632348007456 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 632348007457 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 632348007458 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 632348007459 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 632348007460 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 632348007461 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632348007462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007463 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 632348007464 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 632348007465 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 632348007466 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 632348007467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632348007468 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632348007469 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 632348007470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348007471 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632348007472 Walker A motif; other site 632348007473 ATP binding site [chemical binding]; other site 632348007474 Walker B motif; other site 632348007475 arginine finger; other site 632348007476 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 632348007477 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 632348007478 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 632348007479 Archaeal ATPase; Region: Arch_ATPase; pfam01637 632348007480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007481 Helix-turn-helix domains; Region: HTH; cl00088 632348007482 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 632348007483 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 632348007484 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 632348007485 active site 632348007486 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632348007487 phosphopeptide binding site; other site 632348007488 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 632348007489 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 632348007490 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 632348007491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632348007492 Walker A motif; other site 632348007493 ATP binding site [chemical binding]; other site 632348007494 Walker B motif; other site 632348007495 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 632348007496 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632348007497 ATP binding site [chemical binding]; other site 632348007498 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632348007499 active site 632348007500 ATP binding site [chemical binding]; other site 632348007501 substrate binding site [chemical binding]; other site 632348007502 activation loop (A-loop); other site 632348007503 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 632348007504 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 632348007505 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 632348007506 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 632348007507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 632348007508 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 632348007509 Archaeal ATPase; Region: Arch_ATPase; pfam01637 632348007510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007511 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 632348007512 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 632348007513 Restriction endonuclease; Region: Mrr_cat; cl00516 632348007514 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 632348007515 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 632348007516 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 632348007517 active site 632348007518 intramembrane serine protease GlpG; Provisional; Region: PRK10907 632348007519 Rhomboid family; Region: Rhomboid; cl11446 632348007520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348007521 Domain of unknown function (DUF303); Region: DUF303; pfam03629 632348007522 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 632348007523 Domain of unknown function (DUF303); Region: DUF303; pfam03629 632348007524 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 632348007525 putative active site [active] 632348007526 putative metal binding site [ion binding]; other site 632348007527 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 632348007528 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 632348007529 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 632348007530 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 632348007531 DNA binding site [nucleotide binding] 632348007532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007533 Family description; Region: UvrD_C_2; cl15862 632348007534 YvrJ protein family; Region: YvrJ; pfam12841 632348007535 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 632348007536 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 632348007537 SpoVA protein; Region: SpoVA; cl04298 632348007538 stage V sporulation protein AD; Validated; Region: PRK08304 632348007539 stage V sporulation protein AD; Provisional; Region: PRK12404 632348007540 SpoVA protein; Region: SpoVA; cl04298 632348007541 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 632348007542 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632348007543 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632348007544 substrate binding pocket [chemical binding]; other site 632348007545 membrane-bound complex binding site; other site 632348007546 hinge residues; other site 632348007547 PAS domain S-box; Region: sensory_box; TIGR00229 632348007548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632348007549 putative active site [active] 632348007550 heme pocket [chemical binding]; other site 632348007551 PAS fold; Region: PAS_3; pfam08447 632348007552 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 632348007553 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632348007554 metal binding site [ion binding]; metal-binding site 632348007555 active site 632348007556 I-site; other site 632348007557 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632348007558 WYL domain; Region: WYL; cl14852 632348007559 WYL domain; Region: WYL; cl14852 632348007560 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632348007561 dimerization interface [polypeptide binding]; other site 632348007562 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632348007563 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632348007564 dimer interface [polypeptide binding]; other site 632348007565 putative CheW interface [polypeptide binding]; other site 632348007566 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 632348007567 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 632348007568 Colicin V production protein; Region: Colicin_V; cl00567 632348007569 sensory histidine kinase AtoS; Provisional; Region: PRK11360 632348007570 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 632348007571 ParB-like nuclease domain; Region: ParBc; cl02129 632348007572 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 632348007573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 632348007574 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632348007575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 632348007576 Bacterial Ig-like domain; Region: Big_5; cl01012 632348007577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632348007578 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632348007579 dimerization interface [polypeptide binding]; other site 632348007580 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 632348007581 dimer interface [polypeptide binding]; other site 632348007582 Alkaline phosphatase homologues; Region: alkPPc; smart00098 632348007583 active site 632348007584 ParB-like nuclease domain; Region: ParBc; cl02129 632348007585 ParB-like partition proteins; Region: parB_part; TIGR00180 632348007586 KorB domain; Region: KorB; pfam08535 632348007587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 632348007588 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 632348007589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632348007590 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 632348007591 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 632348007592 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 632348007593 trmE is a tRNA modification GTPase; Region: trmE; cd04164 632348007594 G1 box; other site 632348007595 GTP/Mg2+ binding site [chemical binding]; other site 632348007596 Switch I region; other site 632348007597 G2 box; other site 632348007598 Switch II region; other site 632348007599 G3 box; other site 632348007600 G4 box; other site 632348007601 G5 box; other site 632348007602 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 632348007603 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 632348007604 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 632348007605 G-X-X-G motif; other site 632348007606 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 632348007607 RxxxH motif; other site 632348007608 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 632348007609 Haemolytic domain; Region: Haemolytic; cl00506 632348007610 Ribonuclease P; Region: Ribonuclease_P; cl00457 632348007611 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 632348007612 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 632348007613 Spore germination protein; Region: Spore_permease; cl15802 632348007614 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194