-- dump date 20120504_132834 -- class Genbank::misc_feature -- table misc_feature_note -- id note 511051000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 511051000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 511051000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051000004 Walker A motif; other site 511051000005 ATP binding site [chemical binding]; other site 511051000006 Walker B motif; other site 511051000007 arginine finger; other site 511051000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 511051000009 DnaA box-binding interface [nucleotide binding]; other site 511051000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 511051000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 511051000012 putative DNA binding surface [nucleotide binding]; other site 511051000013 dimer interface [polypeptide binding]; other site 511051000014 beta-clamp/clamp loader binding surface; other site 511051000015 beta-clamp/translesion DNA polymerase binding surface; other site 511051000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 511051000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000018 Walker A/P-loop; other site 511051000019 ATP binding site [chemical binding]; other site 511051000020 Q-loop/lid; other site 511051000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000022 ABC transporter signature motif; other site 511051000023 Walker B; other site 511051000024 D-loop; other site 511051000025 H-loop/switch region; other site 511051000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 511051000027 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 511051000028 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511051000029 homodimer interface [polypeptide binding]; other site 511051000030 substrate-cofactor binding pocket; other site 511051000031 catalytic residue [active] 511051000032 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 511051000033 PAS domain S-box; Region: sensory_box; TIGR00229 511051000034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511051000035 putative active site [active] 511051000036 heme pocket [chemical binding]; other site 511051000037 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000038 metal binding site [ion binding]; metal-binding site 511051000039 active site 511051000040 I-site; other site 511051000041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 511051000042 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 511051000043 Clp amino terminal domain; Region: Clp_N; pfam02861 511051000044 Clp amino terminal domain; Region: Clp_N; pfam02861 511051000045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051000046 Walker A motif; other site 511051000047 ATP binding site [chemical binding]; other site 511051000048 Walker B motif; other site 511051000049 arginine finger; other site 511051000050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051000051 Walker A motif; other site 511051000052 ATP binding site [chemical binding]; other site 511051000053 Walker B motif; other site 511051000054 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511051000055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 511051000056 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 511051000057 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 511051000058 metal binding triad [ion binding]; metal-binding site 511051000059 HEPN domain; Region: HEPN; cl00824 511051000060 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 511051000061 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051000062 dimer interface [polypeptide binding]; other site 511051000063 PYR/PP interface [polypeptide binding]; other site 511051000064 TPP binding site [chemical binding]; other site 511051000065 substrate binding site [chemical binding]; other site 511051000066 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511051000067 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 511051000068 TPP-binding site; other site 511051000069 4Fe-4S binding domain; Region: Fer4; cl02805 511051000070 Cation efflux family; Region: Cation_efflux; cl00316 511051000071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511051000072 Coenzyme A binding pocket [chemical binding]; other site 511051000073 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 511051000074 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000075 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051000076 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511051000077 Cation efflux family; Region: Cation_efflux; cl00316 511051000078 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 511051000079 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 511051000080 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 511051000081 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 511051000082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000083 FeS/SAM binding site; other site 511051000084 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 511051000085 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 511051000086 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511051000087 homodimer interface [polypeptide binding]; other site 511051000088 NAD binding pocket [chemical binding]; other site 511051000089 ATP binding pocket [chemical binding]; other site 511051000090 Mg binding site [ion binding]; other site 511051000091 active-site loop [active] 511051000092 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 511051000093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000094 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 511051000095 golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522 511051000096 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511051000097 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511051000098 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511051000099 Helix-turn-helix domains; Region: HTH; cl00088 511051000100 3H domain; Region: 3H; pfam02829 511051000101 benzoate transport; Region: 2A0115; TIGR00895 511051000102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000104 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000105 Uncharacterized conserved protein [Function unknown]; Region: COG2014 511051000106 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 511051000107 Domain of unknown function (DUF364); Region: DUF364; pfam04016 511051000108 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000109 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 511051000110 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 511051000111 intersubunit interface [polypeptide binding]; other site 511051000112 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 511051000113 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511051000114 Walker A/P-loop; other site 511051000115 ATP binding site [chemical binding]; other site 511051000116 Q-loop/lid; other site 511051000117 ABC transporter signature motif; other site 511051000118 Walker B; other site 511051000119 D-loop; other site 511051000120 H-loop/switch region; other site 511051000121 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511051000122 ABC-ATPase subunit interface; other site 511051000123 dimer interface [polypeptide binding]; other site 511051000124 putative PBP binding regions; other site 511051000125 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 511051000126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000127 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051000128 putative substrate translocation pore; other site 511051000129 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051000130 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051000131 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 511051000132 NlpC/P60 family; Region: NLPC_P60; cl11438 511051000133 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051000134 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051000135 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 511051000136 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 511051000137 BNR repeat-like domain; Region: BNR_2; pfam13088 511051000138 VPS10 domain; Region: VPS10; smart00602 511051000139 NlpC/P60 family; Region: NLPC_P60; cl11438 511051000140 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511051000141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051000142 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051000143 DNA binding residues [nucleotide binding] 511051000144 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511051000145 IHF dimer interface [polypeptide binding]; other site 511051000146 IHF - DNA interface [nucleotide binding]; other site 511051000147 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511051000148 P-loop; other site 511051000149 Magnesium ion binding site [ion binding]; other site 511051000150 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511051000151 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511051000152 Magnesium ion binding site [ion binding]; other site 511051000153 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511051000154 IHF dimer interface [polypeptide binding]; other site 511051000155 IHF - DNA interface [nucleotide binding]; other site 511051000156 Initiator Replication protein; Region: Rep_3; cl03080 511051000157 Domain of unknown function (DUF239); Region: DUF239; pfam03080 511051000158 beta-galactosidase; Provisional; Region: PLN03059 511051000159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000160 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 511051000161 Walker A/P-loop; other site 511051000162 ATP binding site [chemical binding]; other site 511051000163 Q-loop/lid; other site 511051000164 ABC transporter signature motif; other site 511051000165 Walker B; other site 511051000166 D-loop; other site 511051000167 H-loop/switch region; other site 511051000168 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511051000169 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 511051000170 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511051000171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511051000172 Helix-turn-helix domains; Region: HTH; cl00088 511051000173 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 511051000174 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 511051000175 putative NADP binding site [chemical binding]; other site 511051000176 putative substrate binding site [chemical binding]; other site 511051000177 active site 511051000178 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511051000179 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 511051000180 Walker A/P-loop; other site 511051000181 ATP binding site [chemical binding]; other site 511051000182 Q-loop/lid; other site 511051000183 ABC transporter signature motif; other site 511051000184 Walker B; other site 511051000185 D-loop; other site 511051000186 H-loop/switch region; other site 511051000187 TOBE domain; Region: TOBE_2; cl01440 511051000188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000189 dimer interface [polypeptide binding]; other site 511051000190 conserved gate region; other site 511051000191 putative PBP binding loops; other site 511051000192 ABC-ATPase subunit interface; other site 511051000193 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 511051000194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000195 FeS/SAM binding site; other site 511051000196 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 511051000197 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511051000198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000199 Walker A/P-loop; other site 511051000200 ATP binding site [chemical binding]; other site 511051000201 Q-loop/lid; other site 511051000202 ABC transporter signature motif; other site 511051000203 Walker B; other site 511051000204 D-loop; other site 511051000205 H-loop/switch region; other site 511051000206 potential frameshift: common BLAST hit: gi|20807599|ref|NP_622770.1| ABC-type multidrug transport system, permease component 511051000207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000208 Radical SAM superfamily; Region: Radical_SAM; pfam04055 511051000209 FeS/SAM binding site; other site 511051000210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000211 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051000212 putative substrate translocation pore; other site 511051000213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000214 FeS/SAM binding site; other site 511051000215 HTH-like domain; Region: HTH_21; pfam13276 511051000216 Integrase core domain; Region: rve; cl01316 511051000217 Integrase core domain; Region: rve_3; cl15866 511051000218 YcaO-like family; Region: YcaO; pfam02624 511051000219 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 511051000220 bacteriocin biosynthesis cyclodehydratase, SagC family; Region: cyclo_dehy_ocin; TIGR03603 511051000221 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 511051000222 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 511051000223 putative FMN binding site [chemical binding]; other site 511051000224 NADPH bind site [chemical binding]; other site 511051000225 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511051000226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000227 Walker A/P-loop; other site 511051000228 ATP binding site [chemical binding]; other site 511051000229 Q-loop/lid; other site 511051000230 ABC transporter signature motif; other site 511051000231 Walker B; other site 511051000232 D-loop; other site 511051000233 H-loop/switch region; other site 511051000234 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 511051000235 active site 511051000236 CAAX protease self-immunity; Region: Abi; cl00558 511051000237 Integrase core domain; Region: rve_3; cl15866 511051000238 Transposase domain (DUF772); Region: DUF772; pfam05598 511051000239 glucose-6-phosphate 1-dehydrogenase; Region: PLN02539 511051000240 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511051000241 DDE superfamily endonuclease; Region: DDE_4; cl15789 511051000242 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051000243 DDE superfamily endonuclease; Region: DDE_4; cl15789 511051000244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000245 FeS/SAM binding site; other site 511051000246 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051000247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511051000249 dimerization interface [polypeptide binding]; other site 511051000250 putative DNA binding site [nucleotide binding]; other site 511051000251 putative Zn2+ binding site [ion binding]; other site 511051000252 Predicted integral membrane protein [Function unknown]; Region: COG5658 511051000253 SdpI/YhfL protein family; Region: SdpI; pfam13630 511051000254 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 511051000255 SdpI/YhfL protein family; Region: SdpI; pfam13630 511051000256 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511051000257 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511051000258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000259 Walker A/P-loop; other site 511051000260 ATP binding site [chemical binding]; other site 511051000261 Q-loop/lid; other site 511051000262 ABC transporter signature motif; other site 511051000263 Walker B; other site 511051000264 D-loop; other site 511051000265 H-loop/switch region; other site 511051000266 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 511051000267 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000268 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051000270 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511051000271 PAS domain; Region: PAS_10; pfam13596 511051000272 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511051000273 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051000274 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511051000275 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 511051000276 putative active site [active] 511051000277 putative metal binding site [ion binding]; other site 511051000278 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 511051000279 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 511051000280 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511051000281 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511051000282 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511051000283 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511051000284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051000285 dimer interface [polypeptide binding]; other site 511051000286 phosphorylation site [posttranslational modification] 511051000287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051000288 ATP binding site [chemical binding]; other site 511051000289 Mg2+ binding site [ion binding]; other site 511051000290 G-X-G motif; other site 511051000291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511051000292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051000293 active site 511051000294 phosphorylation site [posttranslational modification] 511051000295 intermolecular recognition site; other site 511051000296 dimerization interface [polypeptide binding]; other site 511051000297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511051000298 DNA binding site [nucleotide binding] 511051000299 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 511051000300 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 511051000301 active site 511051000302 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 511051000303 NlpC/P60 family; Region: NLPC_P60; cl11438 511051000304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000305 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 511051000306 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 511051000307 DXD motif; other site 511051000308 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 511051000309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000310 dimer interface [polypeptide binding]; other site 511051000311 conserved gate region; other site 511051000312 putative PBP binding loops; other site 511051000313 ABC-ATPase subunit interface; other site 511051000314 NMT1/THI5 like; Region: NMT1; pfam09084 511051000315 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 511051000316 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 511051000317 Walker A/P-loop; other site 511051000318 ATP binding site [chemical binding]; other site 511051000319 Q-loop/lid; other site 511051000320 ABC transporter signature motif; other site 511051000321 Walker B; other site 511051000322 D-loop; other site 511051000323 H-loop/switch region; other site 511051000324 VPS10 domain; Region: VPS10; smart00602 511051000325 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 511051000326 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000327 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000328 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 511051000329 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 511051000330 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000331 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 511051000332 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000333 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000334 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 511051000335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000336 FeS/SAM binding site; other site 511051000337 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051000338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000339 putative substrate translocation pore; other site 511051000340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000341 Chromate transporter; Region: Chromate_transp; pfam02417 511051000342 Chromate transporter; Region: Chromate_transp; pfam02417 511051000343 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511051000344 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 511051000345 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 511051000346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 511051000347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051000348 Walker A motif; other site 511051000349 ATP binding site [chemical binding]; other site 511051000350 Walker B motif; other site 511051000351 arginine finger; other site 511051000352 Helix-turn-helix domains; Region: HTH; cl00088 511051000353 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 511051000354 trimer interface [polypeptide binding]; other site 511051000355 putative Zn binding site [ion binding]; other site 511051000356 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 511051000357 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 511051000358 tetramer interface [polypeptide binding]; other site 511051000359 TPP-binding site [chemical binding]; other site 511051000360 heterodimer interface [polypeptide binding]; other site 511051000361 phosphorylation loop region [posttranslational modification] 511051000362 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 511051000363 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 511051000364 alpha subunit interface [polypeptide binding]; other site 511051000365 TPP binding site [chemical binding]; other site 511051000366 heterodimer interface [polypeptide binding]; other site 511051000367 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511051000368 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 511051000369 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511051000370 E3 interaction surface; other site 511051000371 lipoyl attachment site [posttranslational modification]; other site 511051000372 e3 binding domain; Region: E3_binding; pfam02817 511051000373 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 511051000374 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000375 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000376 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 511051000377 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 511051000378 DctM-like transporters; Region: DctM; pfam06808 511051000379 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 511051000380 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511051000381 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 511051000382 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 511051000383 dimer interface [polypeptide binding]; other site 511051000384 active site 511051000385 CoA binding pocket [chemical binding]; other site 511051000386 Acyl transferase domain; Region: Acyl_transf_1; cl08282 511051000387 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 511051000388 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 511051000389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051000390 NAD(P) binding site [chemical binding]; other site 511051000391 active site 511051000392 Phosphopantetheine attachment site; Region: PP-binding; cl09936 511051000393 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 511051000394 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 511051000395 dimer interface [polypeptide binding]; other site 511051000396 active site 511051000397 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 511051000398 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 511051000399 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051000400 dimer interface [polypeptide binding]; other site 511051000401 PYR/PP interface [polypeptide binding]; other site 511051000402 TPP binding site [chemical binding]; other site 511051000403 substrate binding site [chemical binding]; other site 511051000404 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11866 511051000405 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511051000406 TPP-binding site [chemical binding]; other site 511051000407 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 511051000408 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 511051000409 diiron binding motif [ion binding]; other site 511051000410 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 511051000411 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 511051000412 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 511051000413 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 511051000414 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 511051000415 metal-binding site [ion binding] 511051000416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511051000417 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511051000418 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 511051000419 putative homodimer interface [polypeptide binding]; other site 511051000420 putative homotetramer interface [polypeptide binding]; other site 511051000421 putative allosteric switch controlling residues; other site 511051000422 putative metal binding site [ion binding]; other site 511051000423 putative homodimer-homodimer interface [polypeptide binding]; other site 511051000424 Short C-terminal domain; Region: SHOCT; cl01373 511051000425 potential frameshift: common BLAST hit: gi|320159705|ref|YP_004172929.1| amidohydrolase family protein 511051000426 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051000427 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 511051000428 active site 511051000429 Protein of unknown function (DUF541); Region: SIMPL; cl01077 511051000430 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051000431 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 511051000432 S-layer homology domain; Region: SLH; pfam00395 511051000433 S-layer homology domain; Region: SLH; pfam00395 511051000434 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 511051000435 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 511051000436 active site 511051000437 metal binding site [ion binding]; metal-binding site 511051000438 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511051000439 Thymidylate synthase complementing protein; Region: Thy1; cl03630 511051000440 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 511051000441 ATP cone domain; Region: ATP-cone; pfam03477 511051000442 Class III ribonucleotide reductase; Region: RNR_III; cd01675 511051000443 effector binding site; other site 511051000444 active site 511051000445 Zn binding site [ion binding]; other site 511051000446 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511051000447 IHF dimer interface [polypeptide binding]; other site 511051000448 IHF - DNA interface [nucleotide binding]; other site 511051000449 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 511051000450 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 511051000451 putative ligand binding site [chemical binding]; other site 511051000452 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 511051000453 TM-ABC transporter signature motif; other site 511051000454 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 511051000455 TM-ABC transporter signature motif; other site 511051000456 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 511051000457 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 511051000458 Walker A/P-loop; other site 511051000459 ATP binding site [chemical binding]; other site 511051000460 Q-loop/lid; other site 511051000461 ABC transporter signature motif; other site 511051000462 Walker B; other site 511051000463 D-loop; other site 511051000464 H-loop/switch region; other site 511051000465 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 511051000466 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 511051000467 Walker A/P-loop; other site 511051000468 ATP binding site [chemical binding]; other site 511051000469 Q-loop/lid; other site 511051000470 ABC transporter signature motif; other site 511051000471 Walker B; other site 511051000472 D-loop; other site 511051000473 H-loop/switch region; other site 511051000474 GatB domain; Region: GatB_Yqey; cl11497 511051000475 Acetokinase family; Region: Acetate_kinase; cl01029 511051000476 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 511051000477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000478 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 511051000479 4Fe-4S binding domain; Region: Fer4; cl02805 511051000480 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 511051000481 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051000482 dimer interface [polypeptide binding]; other site 511051000483 PYR/PP interface [polypeptide binding]; other site 511051000484 TPP binding site [chemical binding]; other site 511051000485 substrate binding site [chemical binding]; other site 511051000486 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511051000487 TPP-binding site [chemical binding]; other site 511051000488 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 511051000489 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 511051000490 Cupin domain; Region: Cupin_2; cl09118 511051000491 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 511051000492 classical (c) SDRs; Region: SDR_c; cd05233 511051000493 NAD(P) binding site [chemical binding]; other site 511051000494 active site 511051000495 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 511051000496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051000497 active site 511051000498 metal binding site [ion binding]; metal-binding site 511051000499 DNA binding site [nucleotide binding] 511051000500 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 511051000501 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511051000502 catalytic residue [active] 511051000503 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051000504 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 511051000505 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000506 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 511051000507 MPT binding site; other site 511051000508 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051000509 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 511051000510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051000511 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 511051000512 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 511051000513 phosphate binding site [ion binding]; other site 511051000514 4Fe-4S binding domain; Region: Fer4; cl02805 511051000515 4Fe-4S binding domain; Region: Fer4; cl02805 511051000516 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 511051000517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 511051000518 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511051000519 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 511051000520 Ligand binding site; other site 511051000521 metal-binding site 511051000522 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 511051000523 XdhC Rossmann domain; Region: XdhC_C; pfam13478 511051000524 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 511051000525 FAD binding domain; Region: FAD_binding_4; pfam01565 511051000526 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 511051000527 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 511051000528 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 511051000529 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511051000530 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 511051000531 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 511051000532 active site 511051000533 putative substrate binding pocket [chemical binding]; other site 511051000534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000535 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 511051000536 Walker A/P-loop; other site 511051000537 ATP binding site [chemical binding]; other site 511051000538 Q-loop/lid; other site 511051000539 ABC transporter signature motif; other site 511051000540 Walker B; other site 511051000541 D-loop; other site 511051000542 H-loop/switch region; other site 511051000543 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511051000544 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511051000545 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051000546 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051000547 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000548 Interdomain contacts; other site 511051000549 Cytokine receptor motif; other site 511051000550 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000551 Interdomain contacts; other site 511051000552 Cytokine receptor motif; other site 511051000553 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000554 Interdomain contacts; other site 511051000555 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 511051000556 Cytokine receptor motif; other site 511051000557 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000558 Interdomain contacts; other site 511051000559 Cytokine receptor motif; other site 511051000560 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000561 Interdomain contacts; other site 511051000562 Cytokine receptor motif; other site 511051000563 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000564 Interdomain contacts; other site 511051000565 Cytokine receptor motif; other site 511051000566 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000567 Interdomain contacts; other site 511051000568 Cytokine receptor motif; other site 511051000569 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000570 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 511051000571 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 511051000572 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 511051000573 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000574 Acetokinase family; Region: Acetate_kinase; cl01029 511051000575 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000576 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000577 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000578 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000579 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000580 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000581 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000582 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000583 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000584 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000585 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000586 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051000587 S-layer homology domain; Region: SLH; pfam00395 511051000588 S-layer homology domain; Region: SLH; pfam00395 511051000589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511051000590 dimerization interface [polypeptide binding]; other site 511051000591 putative DNA binding site [nucleotide binding]; other site 511051000592 putative Zn2+ binding site [ion binding]; other site 511051000593 DGC domain; Region: DGC; cl01742 511051000594 hydrolase; alpha/beta fold family protein; Region: PLN02385 511051000595 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511051000596 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 511051000597 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 511051000598 dimer interface [polypeptide binding]; other site 511051000599 catalytic triad [active] 511051000600 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 511051000601 putative FMN binding site [chemical binding]; other site 511051000602 Isochorismatase family; Region: Isochorismatase; pfam00857 511051000603 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511051000604 catalytic triad [active] 511051000605 conserved cis-peptide bond; other site 511051000606 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 511051000607 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 511051000608 Ligand Binding Site [chemical binding]; other site 511051000609 TIGR00269 family protein; Region: TIGR00269 511051000610 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 511051000611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 511051000612 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 511051000613 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000614 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000615 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 511051000616 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 511051000617 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000618 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 511051000619 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 511051000620 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000621 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000622 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 511051000623 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 511051000624 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 511051000625 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 511051000626 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 511051000627 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 511051000628 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 511051000629 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 511051000630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000631 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 511051000632 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511051000633 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 511051000634 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 511051000635 Arginine repressor [Transcription]; Region: ArgR; COG1438 511051000636 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511051000637 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511051000638 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 511051000639 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 511051000640 ANP binding site [chemical binding]; other site 511051000641 Substrate Binding Site II [chemical binding]; other site 511051000642 Substrate Binding Site I [chemical binding]; other site 511051000643 Lyase; Region: Lyase_1; pfam00206 511051000644 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 511051000645 active sites [active] 511051000646 tetramer interface [polypeptide binding]; other site 511051000647 S-layer homology domain; Region: SLH; pfam00395 511051000648 S-layer homology domain; Region: SLH; pfam00395 511051000649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511051000650 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 511051000651 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 511051000652 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 511051000653 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 511051000654 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 511051000655 potential frameshift: common BLAST hit: gi|298675969|ref|YP_003727719.1| cobyrinic acid ac-diamide synthase 511051000656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000657 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 511051000658 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 511051000659 switch II; other site 511051000660 NlpC/P60 family; Region: NLPC_P60; cl11438 511051000661 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 511051000662 dimer interface [polypeptide binding]; other site 511051000663 catalytic triad [active] 511051000664 diaminopimelate decarboxylase; Region: lysA; TIGR01048 511051000665 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 511051000666 active site 511051000667 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511051000668 substrate binding site [chemical binding]; other site 511051000669 catalytic residues [active] 511051000670 dimer interface [polypeptide binding]; other site 511051000671 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 511051000672 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 511051000673 active site 511051000674 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511051000675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511051000676 DNA-binding site [nucleotide binding]; DNA binding site 511051000677 UTRA domain; Region: UTRA; cl01230 511051000678 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 511051000679 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 511051000680 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 511051000681 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 511051000682 putative active site [active] 511051000683 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 511051000684 S-layer homology domain; Region: SLH; pfam00395 511051000685 S-layer homology domain; Region: SLH; pfam00395 511051000686 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 511051000687 peptide binding site [polypeptide binding]; other site 511051000688 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511051000689 dimer interface [polypeptide binding]; other site 511051000690 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511051000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000692 dimer interface [polypeptide binding]; other site 511051000693 conserved gate region; other site 511051000694 putative PBP binding loops; other site 511051000695 ABC-ATPase subunit interface; other site 511051000696 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 511051000697 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 511051000698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000699 dimer interface [polypeptide binding]; other site 511051000700 conserved gate region; other site 511051000701 putative PBP binding loops; other site 511051000702 ABC-ATPase subunit interface; other site 511051000703 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 511051000704 AP (apurinic/apyrimidinic) site pocket; other site 511051000705 Metal-binding active site; metal-binding site 511051000706 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 511051000707 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511051000708 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 511051000709 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 511051000710 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511051000711 dimer interface [polypeptide binding]; other site 511051000712 active site 511051000713 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511051000714 dimer interface [polypeptide binding]; other site 511051000715 active site 511051000716 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 511051000717 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 511051000718 active site 511051000719 dimer interface [polypeptide binding]; other site 511051000720 Protein of unknown function (DUF422); Region: DUF422; cl00991 511051000721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051000722 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 511051000723 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 511051000724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000725 Walker A/P-loop; other site 511051000726 ATP binding site [chemical binding]; other site 511051000727 Q-loop/lid; other site 511051000728 ABC transporter signature motif; other site 511051000729 Walker B; other site 511051000730 D-loop; other site 511051000731 H-loop/switch region; other site 511051000732 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 511051000733 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 511051000734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511051000735 PAS domain; Region: PAS_9; pfam13426 511051000736 putative active site [active] 511051000737 heme pocket [chemical binding]; other site 511051000738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000739 metal binding site [ion binding]; metal-binding site 511051000740 active site 511051000741 I-site; other site 511051000742 Protein of unknown function (DUF996); Region: DUF996; cl00970 511051000743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000744 metal binding site [ion binding]; metal-binding site 511051000745 active site 511051000746 I-site; other site 511051000747 Cation efflux family; Region: Cation_efflux; cl00316 511051000748 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511051000749 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 511051000750 putative dimer interface [polypeptide binding]; other site 511051000751 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 511051000752 16S/18S rRNA binding site [nucleotide binding]; other site 511051000753 S13e-L30e interaction site [polypeptide binding]; other site 511051000754 25S rRNA binding site [nucleotide binding]; other site 511051000755 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 511051000756 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 511051000757 RNase E interface [polypeptide binding]; other site 511051000758 trimer interface [polypeptide binding]; other site 511051000759 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 511051000760 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 511051000761 RNase E interface [polypeptide binding]; other site 511051000762 trimer interface [polypeptide binding]; other site 511051000763 active site 511051000764 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 511051000765 putative nucleic acid binding region [nucleotide binding]; other site 511051000766 G-X-X-G motif; other site 511051000767 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511051000768 RNA binding site [nucleotide binding]; other site 511051000769 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511051000770 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 511051000771 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511051000772 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 511051000773 Fe-S cluster binding site [ion binding]; other site 511051000774 active site 511051000775 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 511051000776 Protein export membrane protein; Region: SecD_SecF; cl14618 511051000777 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 511051000778 Protein export membrane protein; Region: SecD_SecF; cl14618 511051000779 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051000780 active site 511051000781 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511051000782 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511051000783 synthetase active site [active] 511051000784 NTP binding site [chemical binding]; other site 511051000785 metal binding site [ion binding]; metal-binding site 511051000786 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 511051000787 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 511051000788 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511051000789 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 511051000790 dimerization interface [polypeptide binding]; other site 511051000791 putative tRNAtyr binding site [nucleotide binding]; other site 511051000792 putative active site [active] 511051000793 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 511051000794 catalytic triad [active] 511051000795 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 511051000796 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051000797 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 511051000798 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 511051000799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511051000800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051000801 Zn2+ binding site [ion binding]; other site 511051000802 Mg2+ binding site [ion binding]; other site 511051000803 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 511051000804 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 511051000805 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 511051000806 replicative DNA helicase; Region: DnaB; TIGR00665 511051000807 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 511051000808 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 511051000809 Walker A motif; other site 511051000810 ATP binding site [chemical binding]; other site 511051000811 Walker B motif; other site 511051000812 DNA binding loops [nucleotide binding] 511051000813 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 511051000814 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 511051000815 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 511051000816 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 511051000817 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511051000818 dimer interface [polypeptide binding]; other site 511051000819 ssDNA binding site [nucleotide binding]; other site 511051000820 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511051000821 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 511051000822 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 511051000823 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 511051000824 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 511051000825 trimer interface [polypeptide binding]; other site 511051000826 putative metal binding site [ion binding]; other site 511051000827 Protein of unknown function (DUF554); Region: DUF554; cl00784 511051000828 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511051000829 catalytic core [active] 511051000830 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511051000831 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 511051000832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051000833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051000834 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 511051000835 Protein of unknown function DUF45; Region: DUF45; cl00636 511051000836 hypothetical protein; Reviewed; Region: PRK00024 511051000837 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 511051000838 MPN+ (JAMM) motif; other site 511051000839 Zinc-binding site [ion binding]; other site 511051000840 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 511051000841 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 511051000842 MoaE homodimer interface [polypeptide binding]; other site 511051000843 MoaD interaction [polypeptide binding]; other site 511051000844 active site residues [active] 511051000845 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 511051000846 MoaE interaction surface [polypeptide binding]; other site 511051000847 MoeB interaction surface [polypeptide binding]; other site 511051000848 thiocarboxylated glycine; other site 511051000849 Predicted integral membrane protein [Function unknown]; Region: COG5658 511051000850 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 511051000851 SdpI/YhfL protein family; Region: SdpI; pfam13630 511051000852 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 511051000853 hypothetical protein; Provisional; Region: PRK08185 511051000854 intersubunit interface [polypeptide binding]; other site 511051000855 active site 511051000856 zinc binding site [ion binding]; other site 511051000857 Na+ binding site [ion binding]; other site 511051000858 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 511051000859 transmembrane helices; other site 511051000860 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 511051000861 DNA-binding site [nucleotide binding]; DNA binding site 511051000862 RNA-binding motif; other site 511051000863 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 511051000864 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 511051000865 substrate-cofactor binding pocket; other site 511051000866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051000867 catalytic residue [active] 511051000868 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051000869 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051000870 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051000871 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 511051000872 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 511051000873 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511051000874 DXD motif; other site 511051000875 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511051000876 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 511051000877 Walker A/P-loop; other site 511051000878 ATP binding site [chemical binding]; other site 511051000879 Q-loop/lid; other site 511051000880 ABC transporter signature motif; other site 511051000881 Walker B; other site 511051000882 D-loop; other site 511051000883 H-loop/switch region; other site 511051000884 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 511051000885 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511051000886 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 511051000887 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000888 VID27 cytoplasmic protein; Region: VID27; pfam08553 511051000889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000890 metal binding site [ion binding]; metal-binding site 511051000891 active site 511051000892 I-site; other site 511051000893 Protein of unknown function (DUF812); Region: DUF812; pfam05667 511051000894 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 511051000895 GAF domain; Region: GAF; cl15785 511051000896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000897 metal binding site [ion binding]; metal-binding site 511051000898 active site 511051000899 I-site; other site 511051000900 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 511051000901 GAF domain; Region: GAF; cl15785 511051000902 HDOD domain; Region: HDOD; pfam08668 511051000903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051000904 Zn2+ binding site [ion binding]; other site 511051000905 Mg2+ binding site [ion binding]; other site 511051000906 GTP-binding protein YchF; Reviewed; Region: PRK09601 511051000907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000908 G1 box; other site 511051000909 GTP/Mg2+ binding site [chemical binding]; other site 511051000910 G2 box; other site 511051000911 Switch I region; other site 511051000912 G3 box; other site 511051000913 Switch II region; other site 511051000914 G4 box; other site 511051000915 G5 box; other site 511051000916 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 511051000917 YtxH-like protein; Region: YtxH; cl02079 511051000918 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 511051000919 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 511051000920 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 511051000921 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511051000922 helix-hairpin-helix signature motif; other site 511051000923 substrate binding pocket [chemical binding]; other site 511051000924 active site 511051000925 dipeptidase PepV; Reviewed; Region: PRK07318 511051000926 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 511051000927 active site 511051000928 metal binding site [ion binding]; metal-binding site 511051000929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051000930 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 511051000931 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 511051000932 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 511051000933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511051000934 OsmC-like protein; Region: OsmC; cl00767 511051000935 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051000936 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 511051000937 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511051000938 active site 511051000939 HIGH motif; other site 511051000940 nucleotide binding site [chemical binding]; other site 511051000941 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 511051000942 active site 511051000943 KMSKS motif; other site 511051000944 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 511051000945 tRNA binding surface [nucleotide binding]; other site 511051000946 anticodon binding site; other site 511051000947 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 511051000948 Cation transport protein; Region: TrkH; cl10514 511051000949 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 511051000950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051000951 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 511051000952 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 511051000953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511051000954 motif II; other site 511051000955 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 511051000956 active sites [active] 511051000957 tetramer interface [polypeptide binding]; other site 511051000958 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 511051000959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051000960 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 511051000961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000962 dimer interface [polypeptide binding]; other site 511051000963 conserved gate region; other site 511051000964 putative PBP binding loops; other site 511051000965 ABC-ATPase subunit interface; other site 511051000966 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 511051000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000968 dimer interface [polypeptide binding]; other site 511051000969 conserved gate region; other site 511051000970 putative PBP binding loops; other site 511051000971 ABC-ATPase subunit interface; other site 511051000972 exonuclease SbcC; Region: sbcc; TIGR00618 511051000973 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000974 Walker A/P-loop; other site 511051000975 ATP binding site [chemical binding]; other site 511051000976 exonuclease SbcC; Region: sbcc; TIGR00618 511051000977 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000978 ABC transporter signature motif; other site 511051000979 Walker B; other site 511051000980 D-loop; other site 511051000981 H-loop/switch region; other site 511051000982 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 511051000983 PSP1 C-terminal conserved region; Region: PSP1; cl00770 511051000984 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 511051000985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051000986 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 511051000987 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 511051000988 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 511051000989 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 511051000990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051000991 Acetokinase family; Region: Acetate_kinase; cl01029 511051000992 acetate kinase; Region: ackA; TIGR00016 511051000993 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 511051000994 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 511051000995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051000996 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511051000997 DsrE/DsrF-like family; Region: DrsE; cl00672 511051000998 DsrE/DsrF-like family; Region: DrsE; cl00672 511051000999 DsrE/DsrF-like family; Region: DrsE; cl00672 511051001000 putative inner membrane protein; Provisional; Region: PRK11099 511051001001 Sulphur transport; Region: Sulf_transp; cl01018 511051001002 Sulphur transport; Region: Sulf_transp; cl01018 511051001003 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 511051001004 CPxP motif; other site 511051001005 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 511051001006 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 511051001007 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 511051001008 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 511051001009 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 511051001010 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 511051001011 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 511051001012 NADH dehydrogenase subunit N; Validated; Region: PRK08377 511051001013 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 511051001014 NADH dehydrogenase subunit M; Validated; Region: PRK08668 511051001015 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 511051001016 NADH dehydrogenase; Region: NADHdh; cl00469 511051001017 NADH dehydrogenase subunit B; Validated; Region: PRK06411 511051001018 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 511051001019 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 511051001020 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 511051001021 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 511051001022 putative oxidoreductase; Provisional; Region: PRK13984 511051001023 4Fe-4S binding domain; Region: Fer4; cl02805 511051001024 4Fe-4S binding domain; Region: Fer4; cl02805 511051001025 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051001026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051001027 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 511051001028 protein-splicing catalytic site; other site 511051001029 thioester formation/cholesterol transfer; other site 511051001030 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 511051001031 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 511051001032 dihydropteroate synthase; Region: DHPS; TIGR01496 511051001033 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 511051001034 substrate binding pocket [chemical binding]; other site 511051001035 dimer interface [polypeptide binding]; other site 511051001036 inhibitor binding site; inhibition site 511051001037 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 511051001038 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 511051001039 catalytic center binding site [active] 511051001040 ATP binding site [chemical binding]; other site 511051001041 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 511051001042 putative catalytic site [active] 511051001043 putative phosphate binding site [ion binding]; other site 511051001044 active site 511051001045 metal binding site A [ion binding]; metal-binding site 511051001046 DNA binding site [nucleotide binding] 511051001047 putative AP binding site [nucleotide binding]; other site 511051001048 putative metal binding site B [ion binding]; other site 511051001049 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 511051001050 active site 511051001051 dimerization interface [polypeptide binding]; other site 511051001052 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511051001053 Domain of unknown function (DUF348); Region: DUF348; pfam03990 511051001054 G5 domain; Region: G5; pfam07501 511051001055 3D domain; Region: 3D; cl01439 511051001056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 511051001057 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511051001058 lipoyl attachment site [posttranslational modification]; other site 511051001059 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 511051001060 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 511051001061 tetramer interface [polypeptide binding]; other site 511051001062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001063 catalytic residue [active] 511051001064 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 511051001065 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 511051001066 tetramer interface [polypeptide binding]; other site 511051001067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001068 catalytic residue [active] 511051001069 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 511051001070 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 511051001071 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 511051001072 active site 511051001073 HIGH motif; other site 511051001074 KMSK motif region; other site 511051001075 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511051001076 tRNA binding surface [nucleotide binding]; other site 511051001077 anticodon binding site; other site 511051001078 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 511051001079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511051001080 active site 511051001081 O-Antigen ligase; Region: Wzy_C; cl04850 511051001082 O-Antigen ligase; Region: Wzy_C; cl04850 511051001083 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 511051001084 putative homodimer interface [polypeptide binding]; other site 511051001085 integral membrane protein MviN; Region: mviN; TIGR01695 511051001086 MatE; Region: MatE; cl10513 511051001087 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 511051001088 cytidylate kinase; Provisional; Region: cmk; PRK00023 511051001089 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 511051001090 CMP-binding site; other site 511051001091 The sites determining sugar specificity; other site 511051001092 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511051001093 putative acyl-acceptor binding pocket; other site 511051001094 LytB protein; Region: LYTB; cl00507 511051001095 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 511051001096 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 511051001097 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 511051001098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511051001099 active site 511051001100 catalytic tetrad [active] 511051001101 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051001102 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 511051001103 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 511051001104 FeoA domain; Region: FeoA; cl00838 511051001105 FeoA domain; Region: FeoA; cl00838 511051001106 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 511051001107 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 511051001108 G1 box; other site 511051001109 GTP/Mg2+ binding site [chemical binding]; other site 511051001110 Switch I region; other site 511051001111 G2 box; other site 511051001112 G3 box; other site 511051001113 Switch II region; other site 511051001114 G4 box; other site 511051001115 G5 box; other site 511051001116 Nucleoside recognition; Region: Gate; cl00486 511051001117 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 511051001118 Nucleoside recognition; Region: Gate; cl00486 511051001119 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511051001120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051001121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001122 dimer interface [polypeptide binding]; other site 511051001123 conserved gate region; other site 511051001124 putative PBP binding loops; other site 511051001125 ABC-ATPase subunit interface; other site 511051001126 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051001127 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 511051001128 Walker A/P-loop; other site 511051001129 ATP binding site [chemical binding]; other site 511051001130 Q-loop/lid; other site 511051001131 ABC transporter signature motif; other site 511051001132 Walker B; other site 511051001133 D-loop; other site 511051001134 H-loop/switch region; other site 511051001135 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 511051001136 putative MPT binding site; other site 511051001137 Domain of unknown function (DUF364); Region: DUF364; pfam04016 511051001138 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 511051001139 integral membrane protein MviN; Region: mviN; TIGR01695 511051001140 TIGR00159 family protein; Region: TIGR00159 511051001141 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 511051001142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 511051001143 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 511051001144 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511051001145 active site 511051001146 DNA binding site [nucleotide binding] 511051001147 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 511051001148 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 511051001149 RNA binding site [nucleotide binding]; other site 511051001150 active site 511051001151 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 511051001152 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511051001153 active site 511051001154 Riboflavin kinase; Region: Flavokinase; cl03312 511051001155 Protein of unknown function DUF262; Region: DUF262; cl14890 511051001156 Protein of unknown function DUF262; Region: DUF262; cl14890 511051001157 HsdM N-terminal domain; Region: HsdM_N; pfam12161 511051001158 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 511051001159 probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316 511051001160 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511051001161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051001162 peptidase; Reviewed; Region: PRK13004 511051001163 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 511051001164 putative metal binding site [ion binding]; other site 511051001165 putative dimer interface [polypeptide binding]; other site 511051001166 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 511051001167 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511051001168 putative substrate binding site [chemical binding]; other site 511051001169 nucleotide binding site [chemical binding]; other site 511051001170 nucleotide binding site [chemical binding]; other site 511051001171 homodimer interface [polypeptide binding]; other site 511051001172 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 511051001173 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 511051001174 motif 1; other site 511051001175 active site 511051001176 motif 2; other site 511051001177 motif 3; other site 511051001178 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 511051001179 Sec34-like family; Region: Sec34; pfam04136 511051001180 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 511051001181 YceG-like family; Region: YceG; pfam02618 511051001182 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 511051001183 dimerization interface [polypeptide binding]; other site 511051001184 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 511051001185 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 511051001186 Threonine dehydrogenase; Region: TDH; cd05281 511051001187 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 511051001188 structural Zn binding site [ion binding]; other site 511051001189 catalytic Zn binding site [ion binding]; other site 511051001190 tetramer interface [polypeptide binding]; other site 511051001191 NADP binding site [chemical binding]; other site 511051001192 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 511051001193 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 511051001194 substrate-cofactor binding pocket; other site 511051001195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001196 catalytic residue [active] 511051001197 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 511051001198 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 511051001199 Substrate binding site; other site 511051001200 Mg++ binding site; other site 511051001201 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 511051001202 active site 511051001203 substrate binding site [chemical binding]; other site 511051001204 CoA binding site [chemical binding]; other site 511051001205 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 511051001206 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511051001207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051001208 active site 511051001209 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 511051001210 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 511051001211 5S rRNA interface [nucleotide binding]; other site 511051001212 CTC domain interface [polypeptide binding]; other site 511051001213 L16 interface [polypeptide binding]; other site 511051001214 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 511051001215 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051001216 putative active site [active] 511051001217 metal binding site [ion binding]; metal-binding site 511051001218 homodimer binding site [polypeptide binding]; other site 511051001219 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 511051001220 metal binding triad [ion binding]; metal-binding site 511051001221 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 511051001222 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 511051001223 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511051001224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001225 FeS/SAM binding site; other site 511051001226 TRAM domain; Region: TRAM; cl01282 511051001227 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 511051001228 ScpA/B protein; Region: ScpA_ScpB; cl00598 511051001229 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 511051001230 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 511051001231 active site 511051001232 HIGH motif; other site 511051001233 dimer interface [polypeptide binding]; other site 511051001234 KMSKS motif; other site 511051001235 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 511051001236 active site 511051001237 putative substrate binding region [chemical binding]; other site 511051001238 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051001239 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 511051001240 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 511051001241 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511051001242 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 511051001243 spermine synthase; Region: PLN02823 511051001244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051001245 S-adenosylmethionine binding site [chemical binding]; other site 511051001246 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 511051001247 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 511051001248 active site 511051001249 putative substrate binding pocket [chemical binding]; other site 511051001250 Thiamine pyrophosphokinase; Region: TPK; cd07995 511051001251 active site 511051001252 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 511051001253 dimerization interface [polypeptide binding]; other site 511051001254 thiamine binding site [chemical binding]; other site 511051001255 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 511051001256 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051001257 active site 511051001258 metal binding site [ion binding]; metal-binding site 511051001259 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511051001260 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 511051001261 active site 511051001262 intersubunit interactions; other site 511051001263 catalytic residue [active] 511051001264 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 511051001265 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 511051001266 TPP-binding site [chemical binding]; other site 511051001267 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 511051001268 PYR/PP interface [polypeptide binding]; other site 511051001269 dimer interface [polypeptide binding]; other site 511051001270 TPP binding site [chemical binding]; other site 511051001271 Haemolysin-III related; Region: HlyIII; cl03831 511051001272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051001273 S-adenosylmethionine binding site [chemical binding]; other site 511051001274 Domain of unknown function DUF77; Region: DUF77; cl00307 511051001275 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 511051001276 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 511051001277 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 511051001278 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511051001279 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 511051001280 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 511051001281 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051001282 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051001283 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 511051001284 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511051001285 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 511051001286 Walker A/P-loop; other site 511051001287 ATP binding site [chemical binding]; other site 511051001288 Q-loop/lid; other site 511051001289 ABC transporter signature motif; other site 511051001290 Walker B; other site 511051001291 D-loop; other site 511051001292 H-loop/switch region; other site 511051001293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001294 dimer interface [polypeptide binding]; other site 511051001295 conserved gate region; other site 511051001296 putative PBP binding loops; other site 511051001297 ABC-ATPase subunit interface; other site 511051001298 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051001299 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511051001300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511051001301 substrate binding pocket [chemical binding]; other site 511051001302 membrane-bound complex binding site; other site 511051001303 hinge residues; other site 511051001304 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 511051001305 active site 511051001306 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511051001307 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511051001308 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 511051001309 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051001310 RmuC family; Region: RmuC; pfam02646 511051001311 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051001312 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511051001313 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511051001314 active site 511051001315 catalytic site [active] 511051001316 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511051001317 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511051001318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051001319 Walker A/P-loop; other site 511051001320 ATP binding site [chemical binding]; other site 511051001321 Q-loop/lid; other site 511051001322 ABC transporter signature motif; other site 511051001323 Walker B; other site 511051001324 D-loop; other site 511051001325 H-loop/switch region; other site 511051001326 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511051001327 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 511051001328 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511051001329 Walker A/P-loop; other site 511051001330 ATP binding site [chemical binding]; other site 511051001331 Q-loop/lid; other site 511051001332 ABC transporter signature motif; other site 511051001333 Walker B; other site 511051001334 D-loop; other site 511051001335 H-loop/switch region; other site 511051001336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001337 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 511051001338 FeS/SAM binding site; other site 511051001339 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 511051001340 short chain dehydrogenase; Provisional; Region: PRK06197 511051001341 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 511051001342 putative NAD(P) binding site [chemical binding]; other site 511051001343 active site 511051001344 Protein of unknown function (DUF541); Region: SIMPL; cl01077 511051001345 threonine synthase; Validated; Region: PRK06260 511051001346 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 511051001347 homodimer interface [polypeptide binding]; other site 511051001348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001349 catalytic residue [active] 511051001350 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 511051001351 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 511051001352 putative catalytic residues [active] 511051001353 nucleotide binding site [chemical binding]; other site 511051001354 aspartate binding site [chemical binding]; other site 511051001355 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 511051001356 dimer interface [polypeptide binding]; other site 511051001357 putative threonine allosteric regulatory site; other site 511051001358 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 511051001359 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 511051001360 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 511051001361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051001362 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 511051001363 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 511051001364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511051001365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001366 homodimer interface [polypeptide binding]; other site 511051001367 catalytic residue [active] 511051001368 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 511051001369 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 511051001370 intersubunit interface [polypeptide binding]; other site 511051001371 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 511051001372 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 511051001373 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511051001374 ABC-ATPase subunit interface; other site 511051001375 dimer interface [polypeptide binding]; other site 511051001376 putative PBP binding regions; other site 511051001377 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 511051001378 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 511051001379 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511051001380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001381 FeS/SAM binding site; other site 511051001382 TRAM domain; Region: TRAM; cl01282 511051001383 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 511051001384 active site 511051001385 tetramer interface; other site 511051001386 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 511051001387 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 511051001388 putative active site [active] 511051001389 putative metal binding site [ion binding]; other site 511051001390 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 511051001391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051001392 oligomerization interface [polypeptide binding]; other site 511051001393 active site 511051001394 NAD+ binding site [chemical binding]; other site 511051001395 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 511051001396 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 511051001397 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 511051001398 homodimer interface [polypeptide binding]; other site 511051001399 NADP binding site [chemical binding]; other site 511051001400 substrate binding site [chemical binding]; other site 511051001401 HerA helicase [Replication, recombination, and repair]; Region: COG0433 511051001402 Domain of unknown function DUF87; Region: DUF87; pfam01935 511051001403 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 511051001404 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051001405 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051001406 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051001407 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 511051001408 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 511051001409 putative carbohydrate kinase; Provisional; Region: PRK10565 511051001410 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 511051001411 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 511051001412 putative substrate binding site [chemical binding]; other site 511051001413 putative ATP binding site [chemical binding]; other site 511051001414 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 511051001415 Predicted methyltransferases [General function prediction only]; Region: COG1568 511051001416 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 511051001417 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 511051001418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051001419 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 511051001420 Divergent PAP2 family; Region: DUF212; cl00855 511051001421 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 511051001422 EamA-like transporter family; Region: EamA; cl01037 511051001423 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 511051001424 EamA-like transporter family; Region: EamA; cl01037 511051001425 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 511051001426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051001427 Signal peptide binding domain; Region: SRP_SPB; pfam02978 511051001428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511051001429 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 511051001430 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 511051001431 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511051001432 P loop; other site 511051001433 GTP binding site [chemical binding]; other site 511051001434 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 511051001435 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 511051001436 dimerization interface [polypeptide binding]; other site 511051001437 active site 511051001438 metal binding site [ion binding]; metal-binding site 511051001439 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054 511051001440 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 511051001441 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 511051001442 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 511051001443 HIGH motif; other site 511051001444 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511051001445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511051001446 active site 511051001447 KMSKS motif; other site 511051001448 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 511051001449 tRNA binding surface [nucleotide binding]; other site 511051001450 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 511051001451 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 511051001452 glutaminase active site [active] 511051001453 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511051001454 dimer interface [polypeptide binding]; other site 511051001455 active site 511051001456 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511051001457 dimer interface [polypeptide binding]; other site 511051001458 active site 511051001459 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 511051001460 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 511051001461 active site 511051001462 substrate binding site [chemical binding]; other site 511051001463 metal binding site [ion binding]; metal-binding site 511051001464 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051001465 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 511051001466 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 511051001467 GAF domain; Region: GAF; cl15785 511051001468 Histidine kinase; Region: His_kinase; pfam06580 511051001469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051001470 ATP binding site [chemical binding]; other site 511051001471 Mg2+ binding site [ion binding]; other site 511051001472 G-X-G motif; other site 511051001473 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 511051001474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051001475 active site 511051001476 phosphorylation site [posttranslational modification] 511051001477 intermolecular recognition site; other site 511051001478 dimerization interface [polypeptide binding]; other site 511051001479 LytTr DNA-binding domain; Region: LytTR; cl04498 511051001480 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 511051001481 Carbon starvation protein CstA; Region: CstA; pfam02554 511051001482 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 511051001483 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 511051001484 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 511051001485 P loop; other site 511051001486 Nucleotide binding site [chemical binding]; other site 511051001487 DTAP/Switch II; other site 511051001488 Switch I; other site 511051001489 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051001490 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 511051001491 active site 511051001492 metal binding site [ion binding]; metal-binding site 511051001493 Amino acid permease; Region: AA_permease_2; pfam13520 511051001494 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 511051001495 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511051001496 inhibitor-cofactor binding pocket; inhibition site 511051001497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001498 catalytic residue [active] 511051001499 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 511051001500 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: COG2117 511051001501 Ligand Binding Site [chemical binding]; other site 511051001502 Domain of unknown function (DUF814); Region: DUF814; pfam05670 511051001503 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 511051001504 active site 511051001505 dimer interface [polypeptide binding]; other site 511051001506 catalytic nucleophile [active] 511051001507 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 511051001508 Zn binding site [ion binding]; other site 511051001509 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 511051001510 PhoU domain; Region: PhoU; pfam01895 511051001511 PhoU domain; Region: PhoU; pfam01895 511051001512 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 511051001513 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 511051001514 Walker A/P-loop; other site 511051001515 ATP binding site [chemical binding]; other site 511051001516 Q-loop/lid; other site 511051001517 ABC transporter signature motif; other site 511051001518 Walker B; other site 511051001519 D-loop; other site 511051001520 H-loop/switch region; other site 511051001521 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 511051001522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001523 dimer interface [polypeptide binding]; other site 511051001524 conserved gate region; other site 511051001525 putative PBP binding loops; other site 511051001526 ABC-ATPase subunit interface; other site 511051001527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001528 dimer interface [polypeptide binding]; other site 511051001529 conserved gate region; other site 511051001530 putative PBP binding loops; other site 511051001531 ABC-ATPase subunit interface; other site 511051001532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051001533 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511051001534 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 511051001535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051001536 dimer interface [polypeptide binding]; other site 511051001537 phosphorylation site [posttranslational modification] 511051001538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051001539 ATP binding site [chemical binding]; other site 511051001540 Mg2+ binding site [ion binding]; other site 511051001541 G-X-G motif; other site 511051001542 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511051001543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051001544 active site 511051001545 phosphorylation site [posttranslational modification] 511051001546 intermolecular recognition site; other site 511051001547 dimerization interface [polypeptide binding]; other site 511051001548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511051001549 DNA binding site [nucleotide binding] 511051001550 Protein of unknown function (DUF763); Region: DUF763; cl00620 511051001551 Uncharacterized conserved protein [Function unknown]; Region: COG1739 511051001552 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 511051001553 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 511051001554 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 511051001555 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 511051001556 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 511051001557 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 511051001558 EamA-like transporter family; Region: EamA; cl01037 511051001559 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 511051001560 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 511051001561 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511051001562 Catalytic site [active] 511051001563 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 511051001564 RNA/DNA hybrid binding site [nucleotide binding]; other site 511051001565 active site 511051001566 Restriction endonuclease; Region: Mrr_cat; cl00516 511051001567 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511051001568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051001569 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511051001570 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 511051001571 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 511051001572 putative active site [active] 511051001573 putative metal binding site [ion binding]; other site 511051001574 LexA repressor; Validated; Region: PRK00215 511051001575 Helix-turn-helix domains; Region: HTH; cl00088 511051001576 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511051001577 Catalytic site [active] 511051001578 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511051001579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001580 AAA-like domain; Region: AAA_10; pfam12846 511051001581 Walker A motif; other site 511051001582 ATP binding site [chemical binding]; other site 511051001583 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511051001584 catalytic triad [active] 511051001585 conserved cis-peptide bond; other site 511051001586 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 511051001587 catalytic triad [active] 511051001588 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 511051001589 putative active site pocket [active] 511051001590 cleavage site 511051001591 OPT oligopeptide transporter protein; Region: OPT; cl14607 511051001592 OPT oligopeptide transporter protein; Region: OPT; cl14607 511051001593 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 511051001594 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 511051001595 nucleotide binding pocket [chemical binding]; other site 511051001596 K-X-D-G motif; other site 511051001597 catalytic site [active] 511051001598 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 511051001599 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 511051001600 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 511051001601 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 511051001602 Dimer interface [polypeptide binding]; other site 511051001603 BRCT sequence motif; other site 511051001604 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 511051001605 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 511051001606 Amidase; Region: Amidase; cl11426 511051001607 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 511051001608 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 511051001609 GatB domain; Region: GatB_Yqey; cl11497 511051001610 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 511051001611 putative FMN binding site [chemical binding]; other site 511051001612 LemA family; Region: LemA; cl00742 511051001613 Peptidase family M48; Region: Peptidase_M48; cl12018 511051001614 Survival protein SurE; Region: SurE; cl00448 511051001615 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 511051001616 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511051001617 active site 511051001618 glutamine synthetase, type I; Region: GlnA; TIGR00653 511051001619 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 511051001620 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 511051001621 asparagine synthetase A; Reviewed; Region: PRK06462 511051001622 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 511051001623 motif 1; other site 511051001624 dimer interface [polypeptide binding]; other site 511051001625 active site 511051001626 motif 2; other site 511051001627 motif 3; other site 511051001628 Domain of unknown function DUF20; Region: UPF0118; pfam01594 511051001629 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 511051001630 DNA gyrase subunit A; Validated; Region: PRK05560 511051001631 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 511051001632 CAP-like domain; other site 511051001633 active site 511051001634 primary dimer interface [polypeptide binding]; other site 511051001635 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001636 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001637 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001638 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001639 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001640 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 511051001641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051001642 Mg2+ binding site [ion binding]; other site 511051001643 G-X-G motif; other site 511051001644 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511051001645 anchoring element; other site 511051001646 dimer interface [polypeptide binding]; other site 511051001647 ATP binding site [chemical binding]; other site 511051001648 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511051001649 active site 511051001650 putative metal-binding site [ion binding]; other site 511051001651 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511051001652 Clp protease ATP binding subunit; Region: clpC; CHL00095 511051001653 Clp amino terminal domain; Region: Clp_N; pfam02861 511051001654 Clp amino terminal domain; Region: Clp_N; pfam02861 511051001655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001656 Walker A motif; other site 511051001657 ATP binding site [chemical binding]; other site 511051001658 Walker B motif; other site 511051001659 arginine finger; other site 511051001660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001661 Walker A motif; other site 511051001662 ATP binding site [chemical binding]; other site 511051001663 Walker B motif; other site 511051001664 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511051001665 GTP-binding protein LepA; Provisional; Region: PRK05433 511051001666 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 511051001667 G1 box; other site 511051001668 putative GEF interaction site [polypeptide binding]; other site 511051001669 GTP/Mg2+ binding site [chemical binding]; other site 511051001670 Switch I region; other site 511051001671 G2 box; other site 511051001672 G3 box; other site 511051001673 Switch II region; other site 511051001674 G4 box; other site 511051001675 G5 box; other site 511051001676 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 511051001677 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 511051001678 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 511051001679 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 511051001680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001681 FeS/SAM binding site; other site 511051001682 HemN C-terminal domain; Region: HemN_C; pfam06969 511051001683 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051001684 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 511051001685 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 511051001686 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 511051001687 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 511051001688 phosphate binding site [ion binding]; other site 511051001689 putative substrate binding pocket [chemical binding]; other site 511051001690 dimer interface [polypeptide binding]; other site 511051001691 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 511051001692 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 511051001693 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 511051001694 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 511051001695 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 511051001696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051001697 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 511051001698 Phosphoglycerate kinase; Region: PGK; pfam00162 511051001699 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 511051001700 substrate binding site [chemical binding]; other site 511051001701 hinge regions; other site 511051001702 ADP binding site [chemical binding]; other site 511051001703 catalytic site [active] 511051001704 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051001705 Preprotein translocase SecG subunit; Region: SecG; cl09123 511051001706 potential protein location (hypothetical protein CSE_06520 [Caldisericum exile AZM16c01]) that overlaps RNA (tRNA-F) 511051001707 potential frameshift: common BLAST hit: gi|20808813|ref|NP_623984.1| major facilitator superfamily permease 511051001708 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051001709 Transmembrane secretion effector; Region: MFS_3; pfam05977 511051001710 Chromate transporter; Region: Chromate_transp; pfam02417 511051001711 Chromate transporter; Region: Chromate_transp; pfam02417 511051001712 Chromate transporter; Region: Chromate_transp; pfam02417 511051001713 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051001714 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051001715 Uncharacterized conserved protein [Function unknown]; Region: COG1572 511051001716 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511051001717 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 511051001718 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051001719 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 511051001720 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 511051001721 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 511051001722 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 511051001723 active site 511051001724 homotetramer interface [polypeptide binding]; other site 511051001725 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511051001726 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 511051001727 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 511051001728 active site 511051001729 metal-binding site [ion binding] 511051001730 nucleotide-binding site [chemical binding]; other site 511051001731 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 511051001732 putative ligand binding pocket/active site [active] 511051001733 putative metal binding site [ion binding]; other site 511051001734 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 511051001735 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 511051001736 putative active site [active] 511051001737 putative metal binding site [ion binding]; other site 511051001738 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 511051001739 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511051001740 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 511051001741 active site 511051001742 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 511051001743 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 511051001744 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511051001745 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 511051001746 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511051001747 catalytic loop [active] 511051001748 iron binding site [ion binding]; other site 511051001749 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511051001750 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 511051001751 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 511051001752 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 511051001753 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 511051001754 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 511051001755 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511051001756 RNA binding site [nucleotide binding]; other site 511051001757 Septum formation initiator; Region: DivIC; cl11433 511051001758 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 511051001759 4Fe-4S binding domain; Region: Fer4; cl02805 511051001760 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 511051001761 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 511051001762 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 511051001763 4Fe-4S binding domain; Region: Fer4; cl02805 511051001764 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 511051001765 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051001766 dimer interface [polypeptide binding]; other site 511051001767 PYR/PP interface [polypeptide binding]; other site 511051001768 TPP binding site [chemical binding]; other site 511051001769 substrate binding site [chemical binding]; other site 511051001770 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511051001771 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 511051001772 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 511051001773 TPP-binding site [chemical binding]; other site 511051001774 putative dimer interface [polypeptide binding]; other site 511051001775 Plasmodium yoelii subtelomeric domain PYST-C2; Region: PYST-C2; TIGR01604 511051001776 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 511051001777 Rhomboid family; Region: Rhomboid; cl11446 511051001778 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 511051001779 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 511051001780 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 511051001781 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 511051001782 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 511051001783 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511051001784 HSP70 interaction site [polypeptide binding]; other site 511051001785 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 511051001786 substrate binding site [polypeptide binding]; other site 511051001787 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 511051001788 Zn binding sites [ion binding]; other site 511051001789 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 511051001790 dimer interface [polypeptide binding]; other site 511051001791 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 511051001792 pyruvate kinase; Provisional; Region: PRK05826 511051001793 domain interfaces; other site 511051001794 active site 511051001795 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 511051001796 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 511051001797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051001798 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051001799 putative substrate translocation pore; other site 511051001800 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 511051001801 MatE; Region: MatE; cl10513 511051001802 MatE; Region: MatE; cl10513 511051001803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051001804 Zn2+ binding site [ion binding]; other site 511051001805 Mg2+ binding site [ion binding]; other site 511051001806 hypothetical protein; Provisional; Region: PRK08609 511051001807 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 511051001808 active site 511051001809 primer binding site [nucleotide binding]; other site 511051001810 NTP binding site [chemical binding]; other site 511051001811 metal binding triad [ion binding]; metal-binding site 511051001812 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051001813 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511051001814 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 511051001815 substrate binding site [chemical binding]; other site 511051001816 ATP binding site [chemical binding]; other site 511051001817 excinuclease ABC subunit B; Provisional; Region: PRK05298 511051001818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051001819 ATP binding site [chemical binding]; other site 511051001820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051001821 nucleotide binding region [chemical binding]; other site 511051001822 ATP-binding site [chemical binding]; other site 511051001823 Ultra-violet resistance protein B; Region: UvrB; pfam12344 511051001824 UvrB/uvrC motif; Region: UVR; pfam02151 511051001825 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 511051001826 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 511051001827 active site 511051001828 nucleophile elbow; other site 511051001829 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 511051001830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511051001831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001832 homodimer interface [polypeptide binding]; other site 511051001833 catalytic residue [active] 511051001834 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 511051001835 Moco binding site; other site 511051001836 metal coordination site [ion binding]; other site 511051001837 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 511051001838 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511051001839 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 511051001840 hypothetical protein; Reviewed; Region: PRK09588 511051001841 endonuclease IV; Provisional; Region: PRK01060 511051001842 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 511051001843 AP (apurinic/apyrimidinic) site pocket; other site 511051001844 DNA interaction; other site 511051001845 Metal-binding active site; metal-binding site 511051001846 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 511051001847 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511051001848 catalytic residue [active] 511051001849 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 511051001850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001851 FeS/SAM binding site; other site 511051001852 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 511051001853 membrane protein FdrA; Validated; Region: PRK06091 511051001854 CoA-ligase; Region: Ligase_CoA; cl02894 511051001855 membrane protein FdrA; Validated; Region: PRK06091 511051001856 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 511051001857 Putative cyclase; Region: Cyclase; cl00814 511051001858 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 511051001859 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 511051001860 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 511051001861 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 511051001862 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511051001863 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 511051001864 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 511051001865 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511051001866 xanthine permease; Region: pbuX; TIGR03173 511051001867 trigger factor; Provisional; Region: tig; PRK01490 511051001868 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 511051001869 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 511051001870 Clp protease; Region: CLP_protease; pfam00574 511051001871 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 511051001872 oligomer interface [polypeptide binding]; other site 511051001873 active site residues [active] 511051001874 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 511051001875 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 511051001876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001877 Walker A motif; other site 511051001878 ATP binding site [chemical binding]; other site 511051001879 Walker B motif; other site 511051001880 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511051001881 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 511051001882 Found in ATP-dependent protease La (LON); Region: LON; smart00464 511051001883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001884 Walker A motif; other site 511051001885 ATP binding site [chemical binding]; other site 511051001886 Walker B motif; other site 511051001887 arginine finger; other site 511051001888 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 511051001889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511051001890 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 511051001891 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 511051001892 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511051001893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001894 FeS/SAM binding site; other site 511051001895 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 511051001896 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 511051001897 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 511051001898 recombinase A; Provisional; Region: recA; PRK09354 511051001899 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 511051001900 hexamer interface [polypeptide binding]; other site 511051001901 Walker A motif; other site 511051001902 ATP binding site [chemical binding]; other site 511051001903 Walker B motif; other site 511051001904 RecX family; Region: RecX; cl00936 511051001905 phosphodiesterase; Provisional; Region: PRK12704 511051001906 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511051001907 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 511051001908 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 511051001909 GIY-YIG motif/motif A; other site 511051001910 active site 511051001911 catalytic site [active] 511051001912 putative DNA binding site [nucleotide binding]; other site 511051001913 metal binding site [ion binding]; metal-binding site 511051001914 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 511051001915 Membrane protein of unknown function; Region: DUF360; cl00850 511051001916 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 511051001917 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 511051001918 HflX GTPase family; Region: HflX; cd01878 511051001919 G1 box; other site 511051001920 GTP/Mg2+ binding site [chemical binding]; other site 511051001921 Switch I region; other site 511051001922 G2 box; other site 511051001923 G3 box; other site 511051001924 Switch II region; other site 511051001925 G4 box; other site 511051001926 G5 box; other site 511051001927 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 511051001928 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 511051001929 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 511051001930 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 511051001931 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051001932 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051001933 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 511051001934 putative ligand binding site [chemical binding]; other site 511051001935 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051001936 Helix-turn-helix domains; Region: HTH; cl00088 511051001937 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511051001938 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 511051001939 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 511051001940 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 511051001941 dimer interface [polypeptide binding]; other site 511051001942 anticodon binding site; other site 511051001943 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 511051001944 homodimer interface [polypeptide binding]; other site 511051001945 motif 1; other site 511051001946 active site 511051001947 motif 2; other site 511051001948 GAD domain; Region: GAD; pfam02938 511051001949 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 511051001950 motif 3; other site 511051001951 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 511051001952 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 511051001953 dimer interface [polypeptide binding]; other site 511051001954 motif 1; other site 511051001955 active site 511051001956 motif 2; other site 511051001957 motif 3; other site 511051001958 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 511051001959 anticodon binding site; other site 511051001960 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 511051001961 dinuclear metal binding motif [ion binding]; other site 511051001962 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 511051001963 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 511051001964 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 511051001965 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 511051001966 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 511051001967 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 511051001968 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511051001969 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511051001970 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511051001971 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511051001972 hinge; other site 511051001973 active site 511051001974 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 511051001975 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 511051001976 active site 511051001977 homodimer interface [polypeptide binding]; other site 511051001978 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 511051001979 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 511051001980 Mg++ binding site [ion binding]; other site 511051001981 putative catalytic motif [active] 511051001982 substrate binding site [chemical binding]; other site 511051001983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051001984 active site 511051001985 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 511051001986 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 511051001987 dimer interface [polypeptide binding]; other site 511051001988 active site 511051001989 glycine-pyridoxal phosphate binding site [chemical binding]; other site 511051001990 folate binding site [chemical binding]; other site 511051001991 comF family protein; Region: comF; TIGR00201 511051001992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051001993 active site 511051001994 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 511051001995 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 511051001996 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 511051001997 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 511051001998 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 511051001999 NAD(P) binding site [chemical binding]; other site 511051002000 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 511051002001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002002 urocanate hydratase; Provisional; Region: PRK05414 511051002003 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 511051002004 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511051002005 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511051002006 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511051002007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511051002008 motif II; other site 511051002009 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511051002010 Ubiquitin-like proteins; Region: UBQ; cl00155 511051002011 charged pocket; other site 511051002012 hydrophobic patch; other site 511051002013 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051002014 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051002015 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051002016 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 511051002017 thymidylate kinase; Validated; Region: tmk; PRK00698 511051002018 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 511051002019 TMP-binding site; other site 511051002020 ATP-binding site [chemical binding]; other site 511051002021 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 511051002022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051002023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002024 Walker A motif; other site 511051002025 Walker A/P-loop; other site 511051002026 ATP binding site [chemical binding]; other site 511051002027 ATP binding site [chemical binding]; other site 511051002028 Walker B motif; other site 511051002029 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 511051002030 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 511051002031 Substrate-binding site [chemical binding]; other site 511051002032 Substrate specificity [chemical binding]; other site 511051002033 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 511051002034 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 511051002035 SurA N-terminal domain; Region: SurA_N_3; cl07813 511051002036 PPIC-type PPIASE domain; Region: Rotamase; cl08278 511051002037 PPIC-type PPIASE domain; Region: Rotamase; cl08278 511051002038 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511051002039 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511051002040 Sulfatase; Region: Sulfatase; cl10460 511051002041 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 511051002042 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 511051002043 Y-family of DNA polymerases; Region: PolY; cl12025 511051002044 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 511051002045 ssDNA binding site; other site 511051002046 generic binding surface II; other site 511051002047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051002048 ATP binding site [chemical binding]; other site 511051002049 putative Mg++ binding site [ion binding]; other site 511051002050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051002051 nucleotide binding region [chemical binding]; other site 511051002052 ATP-binding site [chemical binding]; other site 511051002053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051002054 S-adenosylmethionine binding site [chemical binding]; other site 511051002055 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 511051002056 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 511051002057 dimer interface [polypeptide binding]; other site 511051002058 putative functional site; other site 511051002059 putative MPT binding site; other site 511051002060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051002061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051002062 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051002063 putative substrate translocation pore; other site 511051002064 MoxR-like ATPases [General function prediction only]; Region: COG0714 511051002065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002066 Walker A motif; other site 511051002067 ATP binding site [chemical binding]; other site 511051002068 Walker B motif; other site 511051002069 arginine finger; other site 511051002070 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 511051002071 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 511051002072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511051002073 dimerization interface [polypeptide binding]; other site 511051002074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051002075 dimer interface [polypeptide binding]; other site 511051002076 phosphorylation site [posttranslational modification] 511051002077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051002078 ATP binding site [chemical binding]; other site 511051002079 Mg2+ binding site [ion binding]; other site 511051002080 G-X-G motif; other site 511051002081 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 511051002082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051002083 active site 511051002084 phosphorylation site [posttranslational modification] 511051002085 intermolecular recognition site; other site 511051002086 dimerization interface [polypeptide binding]; other site 511051002087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511051002088 DNA binding site [nucleotide binding] 511051002089 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511051002090 elongation factor P; Validated; Region: PRK00529 511051002091 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 511051002092 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 511051002093 RNA binding site [nucleotide binding]; other site 511051002094 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 511051002095 RNA binding site [nucleotide binding]; other site 511051002096 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 511051002097 putative RNA binding site [nucleotide binding]; other site 511051002098 Acylphosphatase; Region: Acylphosphatase; cl00551 511051002099 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 511051002100 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511051002101 substrate binding pocket [chemical binding]; other site 511051002102 chain length determination region; other site 511051002103 substrate-Mg2+ binding site; other site 511051002104 catalytic residues [active] 511051002105 aspartate-rich region 1; other site 511051002106 active site lid residues [active] 511051002107 aspartate-rich region 2; other site 511051002108 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 511051002109 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 511051002110 TPP-binding site; other site 511051002111 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 511051002112 PYR/PP interface [polypeptide binding]; other site 511051002113 dimer interface [polypeptide binding]; other site 511051002114 TPP binding site [chemical binding]; other site 511051002115 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511051002116 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 511051002117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511051002118 RNA binding surface [nucleotide binding]; other site 511051002119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 511051002120 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 511051002121 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 511051002122 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 511051002123 Walker A/P-loop; other site 511051002124 ATP binding site [chemical binding]; other site 511051002125 Q-loop/lid; other site 511051002126 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 511051002127 ABC transporter signature motif; other site 511051002128 Walker B; other site 511051002129 D-loop; other site 511051002130 H-loop/switch region; other site 511051002131 Acetokinase family; Region: Acetate_kinase; cl01029 511051002132 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 511051002133 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 511051002134 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 511051002135 RNA binding site [nucleotide binding]; other site 511051002136 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 511051002137 RNA binding site [nucleotide binding]; other site 511051002138 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 511051002139 RNA binding site [nucleotide binding]; other site 511051002140 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511051002141 RNA binding site [nucleotide binding]; other site 511051002142 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511051002143 Phosphopantetheine attachment site; Region: PP-binding; cl09936 511051002144 prolyl-tRNA synthetase; Provisional; Region: PRK09194 511051002145 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 511051002146 dimer interface [polypeptide binding]; other site 511051002147 motif 1; other site 511051002148 active site 511051002149 motif 2; other site 511051002150 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 511051002151 putative deacylase active site [active] 511051002152 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 511051002153 active site 511051002154 motif 3; other site 511051002155 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 511051002156 anticodon binding site; other site 511051002157 Competence-damaged protein; Region: CinA; cl00666 511051002158 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 511051002159 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 511051002160 active site 511051002161 ADP/pyrophosphate binding site [chemical binding]; other site 511051002162 dimerization interface [polypeptide binding]; other site 511051002163 allosteric effector site; other site 511051002164 fructose-1,6-bisphosphate binding site; other site 511051002165 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 511051002166 active site 511051002167 ADP/pyrophosphate binding site [chemical binding]; other site 511051002168 dimerization interface [polypeptide binding]; other site 511051002169 allosteric effector site; other site 511051002170 fructose-1,6-bisphosphate binding site; other site 511051002171 sensory histidine kinase AtoS; Provisional; Region: PRK11360 511051002172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 511051002173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 511051002174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051002175 dimer interface [polypeptide binding]; other site 511051002176 phosphorylation site [posttranslational modification] 511051002177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051002178 ATP binding site [chemical binding]; other site 511051002179 Mg2+ binding site [ion binding]; other site 511051002180 G-X-G motif; other site 511051002181 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 511051002182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051002183 active site 511051002184 phosphorylation site [posttranslational modification] 511051002185 intermolecular recognition site; other site 511051002186 dimerization interface [polypeptide binding]; other site 511051002187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002188 Walker A motif; other site 511051002189 ATP binding site [chemical binding]; other site 511051002190 Walker B motif; other site 511051002191 arginine finger; other site 511051002192 Helix-turn-helix domains; Region: HTH; cl00088 511051002193 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 511051002194 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 511051002195 metal binding site [ion binding]; metal-binding site 511051002196 dimer interface [polypeptide binding]; other site 511051002197 KWG Leptospira; Region: KWG; pfam07656 511051002198 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 511051002199 rRNA interaction site [nucleotide binding]; other site 511051002200 S8 interaction site; other site 511051002201 putative laminin-1 binding site; other site 511051002202 elongation factor Ts; Reviewed; Region: tsf; PRK12332 511051002203 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 511051002204 Elongation factor TS; Region: EF_TS; pfam00889 511051002205 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 511051002206 putative nucleotide binding site [chemical binding]; other site 511051002207 uridine monophosphate binding site [chemical binding]; other site 511051002208 homohexameric interface [polypeptide binding]; other site 511051002209 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 511051002210 hinge region; other site 511051002211 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 511051002212 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 511051002213 catalytic residue [active] 511051002214 putative FPP diphosphate binding site; other site 511051002215 putative FPP binding hydrophobic cleft; other site 511051002216 dimer interface [polypeptide binding]; other site 511051002217 putative IPP diphosphate binding site; other site 511051002218 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 511051002219 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 511051002220 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 511051002221 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 511051002222 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 511051002223 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 511051002224 active site 511051002225 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 511051002226 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511051002227 putative substrate binding region [chemical binding]; other site 511051002228 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 511051002229 GcpE protein; Region: GcpE; pfam04551 511051002230 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 511051002231 NurA domain; Region: NurA; cl09134 511051002232 Protein of unknown function (DUF401); Region: DUF401; cl00830 511051002233 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 511051002234 active site 511051002235 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 511051002236 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 511051002237 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 511051002238 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051002239 ATP binding site [chemical binding]; other site 511051002240 putative Mg++ binding site [ion binding]; other site 511051002241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051002242 nucleotide binding region [chemical binding]; other site 511051002243 ATP-binding site [chemical binding]; other site 511051002244 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 511051002245 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 511051002246 substrate binding site [chemical binding]; other site 511051002247 dimer interface [polypeptide binding]; other site 511051002248 catalytic triad [active] 511051002249 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 511051002250 active site 511051002251 catalytic motif [active] 511051002252 Zn binding site [ion binding]; other site 511051002253 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 511051002254 Domain of unknown function DUF21; Region: DUF21; pfam01595 511051002255 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511051002256 Transporter associated domain; Region: CorC_HlyC; cl08393 511051002257 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 511051002258 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 511051002259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051002260 Zn2+ binding site [ion binding]; other site 511051002261 Mg2+ binding site [ion binding]; other site 511051002262 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 511051002263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051002264 antiporter inner membrane protein; Provisional; Region: PRK11670 511051002265 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 511051002266 Walker A motif; other site 511051002267 Predicted transcriptional regulator [Transcription]; Region: COG1959 511051002268 Helix-turn-helix domains; Region: HTH; cl00088 511051002269 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 511051002270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051002271 S-adenosylmethionine binding site [chemical binding]; other site 511051002272 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 511051002273 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 511051002274 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 511051002275 peptidase T; Region: peptidase-T; TIGR01882 511051002276 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 511051002277 metal binding site [ion binding]; metal-binding site 511051002278 dimer interface [polypeptide binding]; other site 511051002279 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 511051002280 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 511051002281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051002282 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511051002283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051002284 DNA binding residues [nucleotide binding] 511051002285 DNA primase; Validated; Region: dnaG; PRK05667 511051002286 CHC2 zinc finger; Region: zf-CHC2; cl15369 511051002287 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 511051002288 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 511051002289 active site 511051002290 metal binding site [ion binding]; metal-binding site 511051002291 interdomain interaction site; other site 511051002292 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 511051002293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511051002294 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 511051002295 pyruvate phosphate dikinase; Provisional; Region: PRK09279 511051002296 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 511051002297 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 511051002298 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 511051002299 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 511051002300 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511051002301 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 511051002302 motif 1; other site 511051002303 dimer interface [polypeptide binding]; other site 511051002304 active site 511051002305 motif 2; other site 511051002306 motif 3; other site 511051002307 Recombination protein O N terminal; Region: RecO_N; cl15812 511051002308 DNA repair protein RecO; Region: reco; TIGR00613 511051002309 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511051002310 intersubunit interface [polypeptide binding]; other site 511051002311 active site 511051002312 catalytic residue [active] 511051002313 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 511051002314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002315 Walker A motif; other site 511051002316 ATP binding site [chemical binding]; other site 511051002317 Walker B motif; other site 511051002318 arginine finger; other site 511051002319 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 511051002320 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 511051002321 recombination protein RecR; Reviewed; Region: recR; PRK00076 511051002322 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 511051002323 RecR protein; Region: RecR; pfam02132 511051002324 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 511051002325 putative active site [active] 511051002326 putative metal-binding site [ion binding]; other site 511051002327 tetramer interface [polypeptide binding]; other site 511051002328 enolase; Provisional; Region: eno; PRK00077 511051002329 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 511051002330 dimer interface [polypeptide binding]; other site 511051002331 metal binding site [ion binding]; metal-binding site 511051002332 substrate binding pocket [chemical binding]; other site 511051002333 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 511051002334 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 511051002335 DNA binding site [nucleotide binding] 511051002336 catalytic residue [active] 511051002337 H2TH interface [polypeptide binding]; other site 511051002338 putative catalytic residues [active] 511051002339 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 511051002340 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511051002341 SLBB domain; Region: SLBB; pfam10531 511051002342 comEA protein; Region: comE; TIGR01259 511051002343 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 511051002344 Competence protein; Region: Competence; cl00471 511051002345 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 511051002346 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 511051002347 trimerization site [polypeptide binding]; other site 511051002348 active site 511051002349 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 511051002350 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 511051002351 active site 511051002352 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 511051002353 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051002354 active site 511051002355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051002356 Walker A motif; other site 511051002357 ATP binding site [chemical binding]; other site 511051002358 Walker B motif; other site 511051002359 Predicted transcriptional regulators [Transcription]; Region: COG1318 511051002360 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 511051002361 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 511051002362 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 511051002363 dimer interface [polypeptide binding]; other site 511051002364 putative functional site; other site 511051002365 putative MPT binding site; other site 511051002366 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 511051002367 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 511051002368 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 511051002369 Ligand Binding Site [chemical binding]; other site 511051002370 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 511051002371 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 511051002372 putative active site [active] 511051002373 substrate binding site [chemical binding]; other site 511051002374 putative cosubstrate binding site; other site 511051002375 catalytic site [active] 511051002376 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 511051002377 substrate binding site [chemical binding]; other site 511051002378 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 511051002379 active site 511051002380 catalytic residues [active] 511051002381 metal binding site [ion binding]; metal-binding site 511051002382 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 511051002383 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 511051002384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051002385 S-adenosylmethionine binding site [chemical binding]; other site 511051002386 peptide chain release factor 1; Validated; Region: prfA; PRK00591 511051002387 RF-1 domain; Region: RF-1; cl02875 511051002388 RF-1 domain; Region: RF-1; cl02875 511051002389 thymidine kinase; Provisional; Region: PRK04296 511051002390 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 511051002391 transcription termination factor Rho; Provisional; Region: PRK12608 511051002392 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 511051002393 RNA binding site [nucleotide binding]; other site 511051002394 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051002395 Walker A motif; other site 511051002396 ATP binding site [chemical binding]; other site 511051002397 Walker B motif; other site 511051002398 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 511051002399 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 511051002400 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 511051002401 Ligand Binding Site [chemical binding]; other site 511051002402 B3/4 domain; Region: B3_4; cl11458 511051002403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051002404 active site 511051002405 FtsH Extracellular; Region: FtsH_ext; pfam06480 511051002406 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 511051002407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002408 Walker A motif; other site 511051002409 ATP binding site [chemical binding]; other site 511051002410 Walker B motif; other site 511051002411 arginine finger; other site 511051002412 Peptidase family M41; Region: Peptidase_M41; pfam01434 511051002413 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 511051002414 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511051002415 minor groove reading motif; other site 511051002416 helix-hairpin-helix signature motif; other site 511051002417 substrate binding pocket [chemical binding]; other site 511051002418 active site 511051002419 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 511051002420 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 511051002421 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 511051002422 transmembrane helices; other site 511051002423 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511051002424 Ligand Binding Site [chemical binding]; other site 511051002425 GTPase Era; Reviewed; Region: era; PRK00089 511051002426 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 511051002427 G1 box; other site 511051002428 GTP/Mg2+ binding site [chemical binding]; other site 511051002429 Switch I region; other site 511051002430 G2 box; other site 511051002431 Switch II region; other site 511051002432 G3 box; other site 511051002433 G4 box; other site 511051002434 G5 box; other site 511051002435 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 511051002436 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 511051002437 homotrimer interaction site [polypeptide binding]; other site 511051002438 putative active site [active] 511051002439 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511051002440 Ligand Binding Site [chemical binding]; other site 511051002441 Bacitracin resistance protein BacA; Region: BacA; cl00858 511051002442 intracellular protease, PfpI family; Region: PfpI; TIGR01382 511051002443 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 511051002444 proposed catalytic triad [active] 511051002445 conserved cys residue [active] 511051002446 Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907 511051002447 ADP-ribose binding site [chemical binding]; other site 511051002448 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 511051002449 RNA/DNA hybrid binding site [nucleotide binding]; other site 511051002450 active site 511051002451 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 511051002452 NHL repeat; Region: NHL; pfam01436 511051002453 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 511051002454 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 511051002455 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051002456 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051002457 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 511051002458 putative active site [active] 511051002459 catalytic triad [active] 511051002460 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 511051002461 putative integrin binding motif; other site 511051002462 PA/protease domain interface [polypeptide binding]; other site 511051002463 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 511051002464 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 511051002465 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 511051002466 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 511051002467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511051002468 motif II; other site 511051002469 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 511051002470 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 511051002471 active site 511051002472 NAD binding site [chemical binding]; other site 511051002473 metal binding site [ion binding]; metal-binding site 511051002474 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 511051002475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051002476 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 511051002477 diiron binding motif [ion binding]; other site 511051002478 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051002479 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 511051002480 diiron binding motif [ion binding]; other site 511051002481 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 511051002482 Rubredoxin; Region: Rubredoxin; pfam00301 511051002483 iron binding site [ion binding]; other site 511051002484 Rubrerythrin [Energy production and conversion]; Region: COG1592 511051002485 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 511051002486 binuclear metal center [ion binding]; other site 511051002487 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 511051002488 iron binding site [ion binding]; other site 511051002489 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 511051002490 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 511051002491 ATP binding site [chemical binding]; other site 511051002492 substrate interface [chemical binding]; other site 511051002493 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 511051002494 Ubiquitin-like proteins; Region: UBQ; cl00155 511051002495 charged pocket; other site 511051002496 hydrophobic patch; other site 511051002497 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 511051002498 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 511051002499 trimerization site [polypeptide binding]; other site 511051002500 active site 511051002501 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511051002502 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 511051002503 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511051002504 catalytic residue [active] 511051002505 Domain of unknown function DUF59; Region: DUF59; cl00941 511051002506 Uncharacterized conserved protein [Function unknown]; Region: COG2461 511051002507 Family of unknown function (DUF438); Region: DUF438; pfam04282 511051002508 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 511051002509 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 511051002510 threonine synthase; Validated; Region: PRK06260 511051002511 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 511051002512 homodimer interface [polypeptide binding]; other site 511051002513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051002514 catalytic residue [active] 511051002515 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 511051002516 putative ligand binding site [chemical binding]; other site 511051002517 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 511051002518 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 511051002519 Walker A/P-loop; other site 511051002520 ATP binding site [chemical binding]; other site 511051002521 Q-loop/lid; other site 511051002522 ABC transporter signature motif; other site 511051002523 Walker B; other site 511051002524 D-loop; other site 511051002525 H-loop/switch region; other site 511051002526 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 511051002527 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051002528 TM-ABC transporter signature motif; other site 511051002529 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051002530 TM-ABC transporter signature motif; other site 511051002531 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051002532 allantoinase; Region: allantoinase; TIGR03178 511051002533 active site 511051002534 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 511051002535 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051002536 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 511051002537 active site 511051002538 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051002539 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 511051002540 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 511051002541 active site 511051002542 putative substrate binding pocket [chemical binding]; other site 511051002543 Protein of unknown function (DUF503); Region: DUF503; cl00669 511051002544 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 511051002545 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 511051002546 Walker A/P-loop; other site 511051002547 ATP binding site [chemical binding]; other site 511051002548 Q-loop/lid; other site 511051002549 ABC transporter signature motif; other site 511051002550 Walker B; other site 511051002551 D-loop; other site 511051002552 H-loop/switch region; other site 511051002553 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051002554 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051002555 ADP-glucose phosphorylase; Region: PLN02643 511051002556 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 511051002557 dimer interface [polypeptide binding]; other site 511051002558 active site 511051002559 glycogen synthase; Provisional; Region: glgA; PRK00654 511051002560 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 511051002561 ADP-binding pocket [chemical binding]; other site 511051002562 homodimer interface [polypeptide binding]; other site 511051002563 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 511051002564 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 511051002565 active site 511051002566 substrate binding site [chemical binding]; other site 511051002567 metal binding site [ion binding]; metal-binding site 511051002568 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 511051002569 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 511051002570 active site 511051002571 dimer interface [polypeptide binding]; other site 511051002572 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 511051002573 dimer interface [polypeptide binding]; other site 511051002574 active site 511051002575 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 511051002576 C-terminal peptidase (prc); Region: prc; TIGR00225 511051002577 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 511051002578 protein binding site [polypeptide binding]; other site 511051002579 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 511051002580 Catalytic dyad [active] 511051002581 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 511051002582 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511051002583 catalytic site [active] 511051002584 G-X2-G-X-G-K; other site 511051002585 probable DNA repair protein; Region: TIGR03623 511051002586 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511051002587 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 511051002588 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 511051002589 CoA-binding site [chemical binding]; other site 511051002590 ATP-binding [chemical binding]; other site 511051002591 DNA polymerase I; Provisional; Region: PRK05755 511051002592 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 511051002593 active site 511051002594 metal binding site 1 [ion binding]; metal-binding site 511051002595 putative 5' ssDNA interaction site; other site 511051002596 metal binding site 3; metal-binding site 511051002597 metal binding site 2 [ion binding]; metal-binding site 511051002598 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 511051002599 putative DNA binding site [nucleotide binding]; other site 511051002600 putative metal binding site [ion binding]; other site 511051002601 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 511051002602 active site 511051002603 substrate binding site [chemical binding]; other site 511051002604 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 511051002605 active site 511051002606 DNA binding site [nucleotide binding] 511051002607 catalytic site [active] 511051002608 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 511051002609 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 511051002610 active site 511051002611 NAD binding site [chemical binding]; other site 511051002612 metal binding site [ion binding]; metal-binding site 511051002613 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 511051002614 Sporulation and spore germination; Region: Germane; cl11253 511051002615 Domain of unknown function DUF59; Region: DUF59; cl00941 511051002616 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 511051002617 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 511051002618 inhibitor site; inhibition site 511051002619 active site 511051002620 dimer interface [polypeptide binding]; other site 511051002621 catalytic residue [active] 511051002622 Protein of unknown function DUF89; Region: DUF89; cl15397 511051002623 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 511051002624 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511051002625 peptide binding site [polypeptide binding]; other site 511051002626 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511051002627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051002628 dimer interface [polypeptide binding]; other site 511051002629 conserved gate region; other site 511051002630 putative PBP binding loops; other site 511051002631 ABC-ATPase subunit interface; other site 511051002632 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 511051002633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051002634 dimer interface [polypeptide binding]; other site 511051002635 conserved gate region; other site 511051002636 putative PBP binding loops; other site 511051002637 ABC-ATPase subunit interface; other site 511051002638 QueT transporter; Region: QueT; cl01932 511051002639 Predicted amidohydrolase [General function prediction only]; Region: COG0388 511051002640 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 511051002641 active site 511051002642 catalytic triad [active] 511051002643 dimer interface [polypeptide binding]; other site 511051002644 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511051002645 homodimer interface [polypeptide binding]; other site 511051002646 NAD synthase; Region: NAD_synthase; pfam02540 511051002647 NAD binding pocket [chemical binding]; other site 511051002648 ATP binding pocket [chemical binding]; other site 511051002649 Mg binding site [ion binding]; other site 511051002650 active-site loop [active] 511051002651 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 511051002652 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 511051002653 active site 511051002654 metal binding site [ion binding]; metal-binding site 511051002655 homotetramer interface [polypeptide binding]; other site 511051002656 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 511051002657 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 511051002658 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 511051002659 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511051002660 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511051002661 oligomer interface [polypeptide binding]; other site 511051002662 active site 511051002663 metal binding site [ion binding]; metal-binding site 511051002664 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511051002665 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511051002666 oligomer interface [polypeptide binding]; other site 511051002667 active site 511051002668 metal binding site [ion binding]; metal-binding site 511051002669 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511051002670 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511051002671 oligomer interface [polypeptide binding]; other site 511051002672 active site 511051002673 metal binding site [ion binding]; metal-binding site 511051002674 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 511051002675 active site 511051002676 multimer interface [polypeptide binding]; other site 511051002677 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 511051002678 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 511051002679 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 511051002680 Walker A/P-loop; other site 511051002681 ATP binding site [chemical binding]; other site 511051002682 Q-loop/lid; other site 511051002683 ABC transporter signature motif; other site 511051002684 Walker B; other site 511051002685 D-loop; other site 511051002686 H-loop/switch region; other site 511051002687 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 511051002688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 511051002689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 511051002690 TIGR04076 family protein; Region: TIGR04076 511051002691 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 511051002692 PLD-like domain; Region: PLDc_2; pfam13091 511051002693 putative active site [active] 511051002694 putative catalytic site [active] 511051002695 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051002696 PLD-like domain; Region: PLDc_2; pfam13091 511051002697 putative active site [active] 511051002698 catalytic site [active] 511051002699 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 511051002700 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 511051002701 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 511051002702 B12 binding site [chemical binding]; other site 511051002703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051002704 FeS/SAM binding site; other site 511051002705 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511051002706 Septum formation topological specificity factor MinE; Region: MinE; cl00538 511051002707 septum site-determining protein MinD; Region: minD_bact; TIGR01968 511051002708 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 511051002709 Switch I; other site 511051002710 Switch II; other site 511051002711 septum formation inhibitor; Reviewed; Region: minC; PRK00513 511051002712 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 511051002713 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 511051002714 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511051002715 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511051002716 rod shape-determining protein MreC; Provisional; Region: PRK13922 511051002717 rod shape-determining protein MreC; Region: MreC; pfam04085 511051002718 rod shape-determining protein MreB; Provisional; Region: PRK13927 511051002719 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 511051002720 ATP binding site [chemical binding]; other site 511051002721 profilin binding site; other site 511051002722 Maf-like protein; Region: Maf; pfam02545 511051002723 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 511051002724 active site 511051002725 dimer interface [polypeptide binding]; other site 511051002726 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 511051002727 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 511051002728 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 511051002729 ApbE family; Region: ApbE; cl00643 511051002730 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 511051002731 putative oxidoreductase; Provisional; Region: PRK12831 511051002732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002734 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 511051002735 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 511051002736 FAD binding pocket [chemical binding]; other site 511051002737 FAD binding motif [chemical binding]; other site 511051002738 phosphate binding motif [ion binding]; other site 511051002739 beta-alpha-beta structure motif; other site 511051002740 NAD binding pocket [chemical binding]; other site 511051002741 Iron coordination center [ion binding]; other site 511051002742 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511051002743 active site 511051002744 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 511051002745 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 511051002746 active site 511051002747 HIGH motif; other site 511051002748 KMSKS motif; other site 511051002749 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 511051002750 tRNA binding surface [nucleotide binding]; other site 511051002751 anticodon binding site; other site 511051002752 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 511051002753 dimer interface [polypeptide binding]; other site 511051002754 putative tRNA-binding site [nucleotide binding]; other site 511051002755 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 511051002756 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 511051002757 Oligomerisation domain; Region: Oligomerisation; cl00519 511051002758 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 511051002759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051002761 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 511051002762 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 511051002763 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 511051002764 catalytic residues [active] 511051002765 ornithine carbamoyltransferase; Provisional; Region: PRK00779 511051002766 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511051002767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002768 Predicted GTPase [General function prediction only]; Region: COG2403 511051002769 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051002770 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 511051002771 active site 511051002772 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 511051002773 putative ligand binding pocket/active site [active] 511051002774 putative metal binding site [ion binding]; other site 511051002775 AMMECR1; Region: AMMECR1; cl00911 511051002776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051002777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051002778 putative substrate translocation pore; other site 511051002779 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511051002780 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511051002781 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 511051002782 Walker A/P-loop; other site 511051002783 ATP binding site [chemical binding]; other site 511051002784 Q-loop/lid; other site 511051002785 ABC transporter signature motif; other site 511051002786 Walker B; other site 511051002787 D-loop; other site 511051002788 H-loop/switch region; other site 511051002789 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511051002790 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511051002791 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051002792 Walker A/P-loop; other site 511051002793 ATP binding site [chemical binding]; other site 511051002794 Q-loop/lid; other site 511051002795 ABC transporter signature motif; other site 511051002796 Walker B; other site 511051002797 D-loop; other site 511051002798 H-loop/switch region; other site 511051002799 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 511051002800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002802 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511051002803 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 511051002804 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 511051002805 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 511051002806 Asp23 family; Region: Asp23; cl00574 511051002807 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 511051002808 DAK2 domain; Region: Dak2; cl03685 511051002809 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511051002810 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 511051002811 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511051002812 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 511051002813 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511051002814 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 511051002815 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 511051002816 DHH family; Region: DHH; pfam01368 511051002817 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 511051002818 FOG: CBS domain [General function prediction only]; Region: COG0517 511051002819 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511051002820 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 511051002821 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 511051002822 active site 511051002823 NTP binding site [chemical binding]; other site 511051002824 metal binding triad [ion binding]; metal-binding site 511051002825 MoxR-like ATPases [General function prediction only]; Region: COG0714 511051002826 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051002827 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 511051002828 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 511051002829 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 511051002830 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 511051002831 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 511051002832 catalytic residues [active] 511051002833 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511051002834 catalytic residues [active] 511051002835 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511051002836 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 511051002837 substrate binding site [chemical binding]; other site 511051002838 hexamer interface [polypeptide binding]; other site 511051002839 metal binding site [ion binding]; metal-binding site 511051002840 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511051002841 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511051002842 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511051002843 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 511051002844 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 511051002845 active site 511051002846 (T/H)XGH motif; other site 511051002847 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 511051002848 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 511051002849 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 511051002850 putative dimer interface [polypeptide binding]; other site 511051002851 putative anticodon binding site; other site 511051002852 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 511051002853 homodimer interface [polypeptide binding]; other site 511051002854 motif 1; other site 511051002855 motif 2; other site 511051002856 active site 511051002857 motif 3; other site 511051002858 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 511051002859 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 511051002860 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 511051002861 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 511051002862 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 511051002863 active site 511051002864 Zn binding site [ion binding]; other site 511051002865 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511051002866 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 511051002867 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 511051002868 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511051002869 active site 511051002870 DNA binding site [nucleotide binding] 511051002871 Int/Topo IB signature motif; other site 511051002872 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 511051002873 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 511051002874 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 511051002875 active site 511051002876 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 511051002877 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511051002878 active site 511051002879 catalytic site [active] 511051002880 substrate binding site [chemical binding]; other site 511051002881 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 511051002882 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051002883 Walker A/P-loop; other site 511051002884 ATP binding site [chemical binding]; other site 511051002885 Q-loop/lid; other site 511051002886 ABC transporter signature motif; other site 511051002887 Walker B; other site 511051002888 D-loop; other site 511051002889 H-loop/switch region; other site 511051002890 Smr domain; Region: Smr; cl02619 511051002891 hypothetical protein; Provisional; Region: PRK08609 511051002892 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 511051002893 metal binding triad [ion binding]; metal-binding site 511051002894 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 511051002895 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511051002896 putative tRNA-binding site [nucleotide binding]; other site 511051002897 B3/4 domain; Region: B3_4; cl11458 511051002898 tRNA synthetase B5 domain; Region: B5; cl08394 511051002899 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 511051002900 dimer interface [polypeptide binding]; other site 511051002901 motif 1; other site 511051002902 motif 3; other site 511051002903 motif 2; other site 511051002904 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 511051002905 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 511051002906 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 511051002907 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 511051002908 dimer interface [polypeptide binding]; other site 511051002909 motif 1; other site 511051002910 active site 511051002911 motif 2; other site 511051002912 motif 3; other site 511051002913 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 511051002914 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 511051002915 transmembrane helices; other site 511051002916 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 511051002917 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 511051002918 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 511051002919 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511051002920 TPP-binding site [chemical binding]; other site 511051002921 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 511051002922 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051002923 dimer interface [polypeptide binding]; other site 511051002924 PYR/PP interface [polypeptide binding]; other site 511051002925 TPP binding site [chemical binding]; other site 511051002926 substrate binding site [chemical binding]; other site 511051002927 Ferredoxin [Energy production and conversion]; Region: COG1146 511051002928 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 511051002929 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 511051002930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002931 CoA-ligase; Region: Ligase_CoA; cl02894 511051002932 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 511051002933 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511051002934 CoA-ligase; Region: Ligase_CoA; cl02894 511051002935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 511051002936 YheO-like PAS domain; Region: PAS_6; pfam08348 511051002937 Helix-turn-helix domains; Region: HTH; cl00088 511051002938 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 511051002939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002940 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 511051002941 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 511051002942 4Fe-4S binding domain; Region: Fer4; cl02805 511051002943 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 511051002944 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 511051002945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051002946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051002947 Integrase core domain; Region: rve; cl01316 511051002948 NlpC/P60 family; Region: NLPC_P60; cl11438 511051002949 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 511051002950 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 511051002951 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 511051002952 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 511051002953 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 511051002954 active site 511051002955 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 511051002956 active site 511051002957 DNA polymerase IV; Validated; Region: PRK02406 511051002958 DNA binding site [nucleotide binding] 511051002959 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 511051002960 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511051002961 carboxyltransferase (CT) interaction site; other site 511051002962 biotinylation site [posttranslational modification]; other site 511051002963 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 511051002964 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 511051002965 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 511051002966 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511051002967 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 511051002968 MPT binding site; other site 511051002969 trimer interface [polypeptide binding]; other site 511051002970 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 511051002971 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 511051002972 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 511051002973 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511051002974 protein binding site [polypeptide binding]; other site 511051002975 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 511051002976 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 511051002977 iron binding site [ion binding]; other site 511051002978 S-adenosylmethionine synthetase; Validated; Region: PRK05250 511051002979 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 511051002980 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 511051002981 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 511051002982 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 511051002983 Flavoprotein; Region: Flavoprotein; cl08021 511051002984 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 511051002985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511051002986 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 511051002987 active site 511051002988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 511051002989 B-cell receptor-associated protein 31-like; Region: Bap31; cl02219 511051002990 Peptidase family M23; Region: Peptidase_M23; pfam01551 511051002991 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 511051002992 FtsX-like permease family; Region: FtsX; cl15850 511051002993 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 511051002994 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 511051002995 Walker A/P-loop; other site 511051002996 ATP binding site [chemical binding]; other site 511051002997 Q-loop/lid; other site 511051002998 ABC transporter signature motif; other site 511051002999 Walker B; other site 511051003000 D-loop; other site 511051003001 H-loop/switch region; other site 511051003002 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511051003003 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511051003004 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 511051003005 peptide chain release factor 2; Validated; Region: prfB; PRK00578 511051003006 RF-1 domain; Region: RF-1; cl02875 511051003007 RF-1 domain; Region: RF-1; cl02875 511051003008 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 511051003009 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 511051003010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051003011 nucleotide binding region [chemical binding]; other site 511051003012 ATP-binding site [chemical binding]; other site 511051003013 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 511051003014 30S subunit binding site; other site 511051003015 alanine racemase; Reviewed; Region: alr; PRK00053 511051003016 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 511051003017 active site 511051003018 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511051003019 dimer interface [polypeptide binding]; other site 511051003020 substrate binding site [chemical binding]; other site 511051003021 catalytic residues [active] 511051003022 Survival protein SurE; Region: SurE; cl00448 511051003023 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 511051003024 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 511051003025 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 511051003026 active site 511051003027 Competence protein A; Region: Competence_A; pfam11104 511051003028 Cell division protein FtsA; Region: FtsA; cl11496 511051003029 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 511051003030 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 511051003031 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 511051003032 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 511051003033 Ribosome-binding factor A; Region: RBFA; cl00542 511051003034 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 511051003035 DHH family; Region: DHH; pfam01368 511051003036 DHHA1 domain; Region: DHHA1; pfam02272 511051003037 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 511051003038 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 511051003039 tandem repeat interface [polypeptide binding]; other site 511051003040 oligomer interface [polypeptide binding]; other site 511051003041 active site residues [active] 511051003042 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 511051003043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051003044 Family description; Region: UvrD_C_2; cl15862 511051003045 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 511051003046 CoenzymeA binding site [chemical binding]; other site 511051003047 subunit interaction site [polypeptide binding]; other site 511051003048 PHB binding site; other site 511051003049 Transglycosylase; Region: Transgly; cl07896 511051003050 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 511051003051 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511051003052 seryl-tRNA synthetase; Provisional; Region: PRK05431 511051003053 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 511051003054 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 511051003055 dimer interface [polypeptide binding]; other site 511051003056 active site 511051003057 motif 1; other site 511051003058 motif 2; other site 511051003059 motif 3; other site 511051003060 Sulfatase; Region: Sulfatase; cl10460 511051003061 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 511051003062 EamA-like transporter family; Region: EamA; cl01037 511051003063 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 511051003064 EamA-like transporter family; Region: EamA; cl01037 511051003065 Protein of unknown function DUF72; Region: DUF72; cl00777 511051003066 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 511051003067 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 511051003068 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 511051003069 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 511051003070 MOFRL family; Region: MOFRL; pfam05161 511051003071 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 511051003072 active site 511051003073 multimer interface [polypeptide binding]; other site 511051003074 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 511051003075 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 511051003076 predicted active site [active] 511051003077 catalytic triad [active] 511051003078 Transcriptional regulator; Region: Transcrip_reg; cl00361 511051003079 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 511051003080 active site 511051003081 putative DNA-binding cleft [nucleotide binding]; other site 511051003082 dimer interface [polypeptide binding]; other site 511051003083 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 511051003084 RuvA N terminal domain; Region: RuvA_N; pfam01330 511051003085 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 511051003086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051003087 Walker A motif; other site 511051003088 ATP binding site [chemical binding]; other site 511051003089 Walker B motif; other site 511051003090 arginine finger; other site 511051003091 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 511051003092 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 511051003093 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 511051003094 ligand binding site; other site 511051003095 oligomer interface; other site 511051003096 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 511051003097 dimer interface [polypeptide binding]; other site 511051003098 N-terminal domain interface [polypeptide binding]; other site 511051003099 sulfate 1 binding site; other site 511051003100 Uncharacterized conserved protein [Function unknown]; Region: COG1543 511051003101 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 511051003102 active site 511051003103 substrate binding site [chemical binding]; other site 511051003104 catalytic site [active] 511051003105 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 511051003106 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511051003107 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 511051003108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 511051003109 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 511051003110 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 511051003111 core dimer interface [polypeptide binding]; other site 511051003112 peripheral dimer interface [polypeptide binding]; other site 511051003113 L10 interface [polypeptide binding]; other site 511051003114 L11 interface [polypeptide binding]; other site 511051003115 putative EF-Tu interaction site [polypeptide binding]; other site 511051003116 putative EF-G interaction site [polypeptide binding]; other site 511051003117 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 511051003118 23S rRNA interface [nucleotide binding]; other site 511051003119 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 511051003120 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 511051003121 mRNA/rRNA interface [nucleotide binding]; other site 511051003122 Ribosomal protein L11/L12; Region: RL11; smart00649 511051003123 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 511051003124 putative thiostrepton binding site; other site 511051003125 23S rRNA interface [nucleotide binding]; other site 511051003126 L7/L12 interface [polypeptide binding]; other site 511051003127 L25 interface [polypeptide binding]; other site 511051003128 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 511051003129 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 511051003130 putative homodimer interface [polypeptide binding]; other site 511051003131 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 511051003132 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 511051003133 elongation factor Tu; Reviewed; Region: PRK00049 511051003134 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511051003135 G1 box; other site 511051003136 GEF interaction site [polypeptide binding]; other site 511051003137 GTP/Mg2+ binding site [chemical binding]; other site 511051003138 Switch I region; other site 511051003139 G2 box; other site 511051003140 G3 box; other site 511051003141 Switch II region; other site 511051003142 G4 box; other site 511051003143 G5 box; other site 511051003144 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511051003145 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511051003146 Antibiotic Binding Site [chemical binding]; other site 511051003147 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511051003148 RNA polymerase factor sigma-70; Validated; Region: PRK08295 511051003149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511051003150 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 511051003151 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 511051003152 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 511051003153 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 511051003154 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511051003155 active site 511051003156 HIGH motif; other site 511051003157 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511051003158 KMSKS motif; other site 511051003159 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511051003160 tRNA binding surface [nucleotide binding]; other site 511051003161 anticodon binding site; other site 511051003162 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511051003163 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511051003164 active site 511051003165 HIGH motif; other site 511051003166 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511051003167 active site 511051003168 KMSKS motif; other site 511051003169 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 511051003170 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 511051003171 23S rRNA interface [nucleotide binding]; other site 511051003172 L3 interface [polypeptide binding]; other site 511051003173 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 511051003174 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 511051003175 active site 511051003176 Cobalt transport protein; Region: CbiQ; cl00463 511051003177 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511051003178 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511051003179 Walker A/P-loop; other site 511051003180 ATP binding site [chemical binding]; other site 511051003181 Q-loop/lid; other site 511051003182 ABC transporter signature motif; other site 511051003183 Walker B; other site 511051003184 D-loop; other site 511051003185 H-loop/switch region; other site 511051003186 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 511051003187 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511051003188 Walker A/P-loop; other site 511051003189 ATP binding site [chemical binding]; other site 511051003190 Q-loop/lid; other site 511051003191 ABC transporter signature motif; other site 511051003192 Walker B; other site 511051003193 D-loop; other site 511051003194 H-loop/switch region; other site 511051003195 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 511051003196 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 511051003197 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 511051003198 alphaNTD - beta interaction site [polypeptide binding]; other site 511051003199 alphaNTD homodimer interface [polypeptide binding]; other site 511051003200 alphaNTD - beta' interaction site [polypeptide binding]; other site 511051003201 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 511051003202 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 511051003203 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 511051003204 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511051003205 RNA binding surface [nucleotide binding]; other site 511051003206 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 511051003207 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 511051003208 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 511051003209 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 511051003210 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 511051003211 rRNA binding site [nucleotide binding]; other site 511051003212 predicted 30S ribosome binding site; other site 511051003213 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 511051003214 active site 511051003215 adenylate kinase; Reviewed; Region: adk; PRK00279 511051003216 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 511051003217 AMP-binding site [chemical binding]; other site 511051003218 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 511051003219 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 511051003220 SecY translocase; Region: SecY; pfam00344 511051003221 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 511051003222 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 511051003223 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 511051003224 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 511051003225 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 511051003226 23S rRNA interface [nucleotide binding]; other site 511051003227 5S rRNA interface [nucleotide binding]; other site 511051003228 L27 interface [polypeptide binding]; other site 511051003229 L5 interface [polypeptide binding]; other site 511051003230 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 511051003231 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511051003232 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511051003233 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 511051003234 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 511051003235 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 511051003236 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 511051003237 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 511051003238 KOW motif; Region: KOW; cl00354 511051003239 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 511051003240 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 511051003241 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 511051003242 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 511051003243 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 511051003244 23S rRNA interface [nucleotide binding]; other site 511051003245 putative translocon interaction site; other site 511051003246 signal recognition particle (SRP54) interaction site; other site 511051003247 L23 interface [polypeptide binding]; other site 511051003248 trigger factor interaction site; other site 511051003249 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 511051003250 23S rRNA interface [nucleotide binding]; other site 511051003251 5S rRNA interface [nucleotide binding]; other site 511051003252 putative antibiotic binding site [chemical binding]; other site 511051003253 L25 interface [polypeptide binding]; other site 511051003254 L27 interface [polypeptide binding]; other site 511051003255 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 511051003256 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 511051003257 G-X-X-G motif; other site 511051003258 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 511051003259 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 511051003260 putative translocon binding site; other site 511051003261 protein-rRNA interface [nucleotide binding]; other site 511051003262 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 511051003263 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 511051003264 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 511051003265 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 511051003266 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 511051003267 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 511051003268 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 511051003269 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 511051003270 elongation factor Tu; Reviewed; Region: PRK00049 511051003271 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511051003272 G1 box; other site 511051003273 GEF interaction site [polypeptide binding]; other site 511051003274 GTP/Mg2+ binding site [chemical binding]; other site 511051003275 Switch I region; other site 511051003276 G2 box; other site 511051003277 G3 box; other site 511051003278 Switch II region; other site 511051003279 G4 box; other site 511051003280 G5 box; other site 511051003281 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511051003282 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511051003283 Antibiotic Binding Site [chemical binding]; other site 511051003284 elongation factor G; Reviewed; Region: PRK00007 511051003285 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 511051003286 G1 box; other site 511051003287 putative GEF interaction site [polypeptide binding]; other site 511051003288 GTP/Mg2+ binding site [chemical binding]; other site 511051003289 Switch I region; other site 511051003290 G2 box; other site 511051003291 G3 box; other site 511051003292 Switch II region; other site 511051003293 G4 box; other site 511051003294 G5 box; other site 511051003295 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511051003296 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511051003297 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511051003298 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 511051003299 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 511051003300 S17 interaction site [polypeptide binding]; other site 511051003301 S8 interaction site; other site 511051003302 16S rRNA interaction site [nucleotide binding]; other site 511051003303 streptomycin interaction site [chemical binding]; other site 511051003304 23S rRNA interaction site [nucleotide binding]; other site 511051003305 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 511051003306 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 511051003307 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 511051003308 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 511051003309 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 511051003310 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 511051003311 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 511051003312 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 511051003313 G-loop; other site 511051003314 DNA binding site [nucleotide binding] 511051003315 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 511051003316 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 511051003317 elongation factor G; Reviewed; Region: PRK12740 511051003318 G1 box; other site 511051003319 putative GEF interaction site [polypeptide binding]; other site 511051003320 GTP/Mg2+ binding site [chemical binding]; other site 511051003321 Switch I region; other site 511051003322 G2 box; other site 511051003323 G3 box; other site 511051003324 Switch II region; other site 511051003325 G4 box; other site 511051003326 G5 box; other site 511051003327 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511051003328 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511051003329 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511051003330 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 511051003331 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 511051003332 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 511051003333 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 511051003334 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 511051003335 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511051003336 RPB10 interaction site [polypeptide binding]; other site 511051003337 RPB1 interaction site [polypeptide binding]; other site 511051003338 RPB11 interaction site [polypeptide binding]; other site 511051003339 RPB3 interaction site [polypeptide binding]; other site 511051003340 RPB12 interaction site [polypeptide binding]; other site 511051003341 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 511051003342 trimer interface [polypeptide binding]; other site 511051003343 dimer interface [polypeptide binding]; other site 511051003344 putative active site [active] 511051003345 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 511051003346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051003347 FeS/SAM binding site; other site 511051003348 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 511051003349 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 511051003350 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 511051003351 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 511051003352 Ligand binding site; other site 511051003353 Putative Catalytic site; other site 511051003354 DXD motif; other site 511051003355 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 511051003356 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 511051003357 putative acyl-acceptor binding pocket; other site 511051003358 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 511051003359 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511051003360 dimer interface [polypeptide binding]; other site 511051003361 ADP-ribose binding site [chemical binding]; other site 511051003362 active site 511051003363 nudix motif; other site 511051003364 metal binding site [ion binding]; metal-binding site 511051003365 ATP synthase subunit D; Region: ATP-synt_D; cl00613 511051003366 V-type ATP synthase subunit B; Provisional; Region: PRK04196 511051003367 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 511051003368 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 511051003369 Walker A motif homologous position; other site 511051003370 Walker B motif; other site 511051003371 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511051003372 V-type ATP synthase subunit A; Provisional; Region: PRK04192 511051003373 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 511051003374 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 511051003375 Walker A motif/ATP binding site; other site 511051003376 Walker B motif; other site 511051003377 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511051003378 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 511051003379 ATP synthase subunit C; Region: ATP-synt_C; cl00466 511051003380 V-type ATP synthase subunit K; Validated; Region: PRK06558 511051003381 V-type ATP synthase subunit I; Validated; Region: PRK05771 511051003382 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 511051003383 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 511051003384 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 511051003385 homodimer interface [polypeptide binding]; other site 511051003386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051003387 catalytic residue [active] 511051003388 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 511051003389 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 511051003390 Putative zinc ribbon domain; Region: DUF164; pfam02591 511051003391 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 511051003392 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 511051003393 Walker A/P-loop; other site 511051003394 ATP binding site [chemical binding]; other site 511051003395 Q-loop/lid; other site 511051003396 ABC transporter signature motif; other site 511051003397 Walker B; other site 511051003398 D-loop; other site 511051003399 H-loop/switch region; other site 511051003400 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511051003401 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 511051003402 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 511051003403 Walker A/P-loop; other site 511051003404 ATP binding site [chemical binding]; other site 511051003405 Q-loop/lid; other site 511051003406 ABC transporter signature motif; other site 511051003407 Walker B; other site 511051003408 D-loop; other site 511051003409 H-loop/switch region; other site 511051003410 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511051003411 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 511051003412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003413 dimer interface [polypeptide binding]; other site 511051003414 conserved gate region; other site 511051003415 putative PBP binding loops; other site 511051003416 ABC-ATPase subunit interface; other site 511051003417 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511051003418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003419 dimer interface [polypeptide binding]; other site 511051003420 conserved gate region; other site 511051003421 putative PBP binding loops; other site 511051003422 ABC-ATPase subunit interface; other site 511051003423 S-layer homology domain; Region: SLH; pfam00395 511051003424 S-layer homology domain; Region: SLH; pfam00395 511051003425 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 511051003426 peptide binding site [polypeptide binding]; other site 511051003427 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511051003428 dimer interface [polypeptide binding]; other site 511051003429 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 511051003430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051003431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051003432 DNA binding residues [nucleotide binding] 511051003433 HlyD family secretion protein; Region: HlyD_2; pfam12700 511051003434 cell division protein FtsZ; Validated; Region: PRK09330 511051003435 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 511051003436 nucleotide binding site [chemical binding]; other site 511051003437 SulA interaction site; other site 511051003438 cell division protein FtsA; Region: ftsA; TIGR01174 511051003439 Cell division protein FtsA; Region: FtsA; cl11496 511051003440 Cell division protein FtsA; Region: FtsA; cl11496 511051003441 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 511051003442 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 511051003443 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511051003444 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 511051003445 FAD binding domain; Region: FAD_binding_4; pfam01565 511051003446 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 511051003447 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 511051003448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003449 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003450 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 511051003451 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 511051003452 active site 511051003453 homodimer interface [polypeptide binding]; other site 511051003454 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511051003455 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 511051003456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003457 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003458 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 511051003459 Mg++ binding site [ion binding]; other site 511051003460 putative catalytic motif [active] 511051003461 putative substrate binding site [chemical binding]; other site 511051003462 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 511051003463 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511051003464 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003465 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003466 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 511051003467 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511051003468 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003469 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003470 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511051003471 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511051003472 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511051003473 Septum formation initiator; Region: DivIC; cl11433 511051003474 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 511051003475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 511051003476 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 511051003477 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 511051003478 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 511051003479 GTP binding site; other site 511051003480 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 511051003481 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 511051003482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511051003483 catalytic loop [active] 511051003484 iron binding site [ion binding]; other site 511051003485 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 511051003486 4Fe-4S binding domain; Region: Fer4; cl02805 511051003487 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 511051003488 [4Fe-4S] binding site [ion binding]; other site 511051003489 molybdopterin cofactor binding site; other site 511051003490 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 511051003491 molybdopterin cofactor binding site; other site 511051003492 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 511051003493 dimer interface [polypeptide binding]; other site 511051003494 [2Fe-2S] cluster binding site [ion binding]; other site 511051003495 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 511051003496 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 511051003497 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 511051003498 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 511051003499 putative dimer interface [polypeptide binding]; other site 511051003500 [2Fe-2S] cluster binding site [ion binding]; other site 511051003501 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 511051003502 dimer interface [polypeptide binding]; other site 511051003503 [2Fe-2S] cluster binding site [ion binding]; other site 511051003504 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 511051003505 SLBB domain; Region: SLBB; pfam10531 511051003506 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 511051003507 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 511051003508 dimer interface [polypeptide binding]; other site 511051003509 [2Fe-2S] cluster binding site [ion binding]; other site 511051003510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051003511 ATP binding site [chemical binding]; other site 511051003512 Mg2+ binding site [ion binding]; other site 511051003513 G-X-G motif; other site 511051003514 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 511051003515 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 511051003516 putative dimer interface [polypeptide binding]; other site 511051003517 [2Fe-2S] cluster binding site [ion binding]; other site 511051003518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511051003519 dimerization interface [polypeptide binding]; other site 511051003520 putative Zn2+ binding site [ion binding]; other site 511051003521 putative DNA binding site [nucleotide binding]; other site 511051003522 DRTGG domain; Region: DRTGG; cl12147 511051003523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 511051003524 DRTGG domain; Region: DRTGG; cl12147 511051003525 ferredoxin; Validated; Region: PRK07118 511051003526 Putative Fe-S cluster; Region: FeS; pfam04060 511051003527 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 511051003528 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 511051003529 FMN-binding domain; Region: FMN_bind; cl01081 511051003530 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 511051003531 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 511051003532 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 511051003533 SLBB domain; Region: SLBB; pfam10531 511051003534 Double zinc ribbon; Region: DZR; pfam12773 511051003535 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 511051003536 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 511051003537 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003538 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003539 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 511051003540 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511051003541 active site 511051003542 HIGH motif; other site 511051003543 nucleotide binding site [chemical binding]; other site 511051003544 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511051003545 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 511051003546 active site 511051003547 KMSKS motif; other site 511051003548 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 511051003549 tRNA binding surface [nucleotide binding]; other site 511051003550 anticodon binding site; other site 511051003551 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 511051003552 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 511051003553 trimer interface [polypeptide binding]; other site 511051003554 putative Zn binding site [ion binding]; other site 511051003555 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 511051003556 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 511051003557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511051003558 RNA binding surface [nucleotide binding]; other site 511051003559 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511051003560 active site 511051003561 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 511051003562 SmpB-tmRNA interface; other site 511051003563 Bacterial SH3 domain; Region: SH3_3; cl02551 511051003564 Bacterial SH3 domain; Region: SH3_3; cl02551 511051003565 Bacterial SH3 domain; Region: SH3_3; cl02551 511051003566 Bacterial SH3 domain; Region: SH3_3; cl02551 511051003567 AMIN domain; Region: AMIN; pfam11741 511051003568 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511051003569 active site 511051003570 metal binding site [ion binding]; metal-binding site 511051003571 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 511051003572 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 511051003573 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 511051003574 putative NAD(P) binding site [chemical binding]; other site 511051003575 putative substrate binding site [chemical binding]; other site 511051003576 catalytic Zn binding site [ion binding]; other site 511051003577 structural Zn binding site [ion binding]; other site 511051003578 UGMP family protein; Validated; Region: PRK09604 511051003579 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 511051003580 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 511051003581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511051003582 Coenzyme A binding pocket [chemical binding]; other site 511051003583 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 511051003584 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 511051003585 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 511051003586 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 511051003587 oligomerisation interface [polypeptide binding]; other site 511051003588 mobile loop; other site 511051003589 roof hairpin; other site 511051003590 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 511051003591 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 511051003592 ring oligomerisation interface [polypeptide binding]; other site 511051003593 ATP/Mg binding site [chemical binding]; other site 511051003594 stacking interactions; other site 511051003595 hinge regions; other site 511051003596 Integrase core domain; Region: rve; cl01316 511051003597 Helix-turn-helix domains; Region: HTH; cl00088 511051003598 Helix-turn-helix domains; Region: HTH; cl00088 511051003599 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511051003600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051003601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051003602 DNA binding residues [nucleotide binding] 511051003603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511051003604 TPR motif; other site 511051003605 binding surface 511051003606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511051003607 binding surface 511051003608 TPR motif; other site 511051003609 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 511051003610 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511051003611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 511051003612 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 511051003613 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511051003614 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511051003615 active site 511051003616 HIGH motif; other site 511051003617 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511051003618 active site 511051003619 KMSKS motif; other site 511051003620 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 511051003621 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 511051003622 Creatinine amidohydrolase; Region: Creatininase; cl00618 511051003623 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 511051003624 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 511051003625 Ferritin-like domain; Region: Ferritin; pfam00210 511051003626 ferroxidase diiron center [ion binding]; other site 511051003627 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 511051003628 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 511051003629 non-heme iron binding site [ion binding]; other site 511051003630 dimer interface [polypeptide binding]; other site 511051003631 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 511051003632 non-heme iron binding site [ion binding]; other site 511051003633 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 511051003634 non-heme iron binding site [ion binding]; other site 511051003635 tetramer interface [polypeptide binding]; other site 511051003636 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 511051003637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051003638 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511051003639 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 511051003640 homotrimer interaction site [polypeptide binding]; other site 511051003641 zinc binding site [ion binding]; other site 511051003642 CDP-binding sites; other site 511051003643 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 511051003644 substrate binding site; other site 511051003645 dimer interface; other site 511051003646 DNA repair protein RadA; Provisional; Region: PRK11823 511051003647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051003648 Walker A motif; other site 511051003649 ATP binding site [chemical binding]; other site 511051003650 Walker B motif; other site 511051003651 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 511051003652 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 511051003653 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 511051003654 dimer interface [polypeptide binding]; other site 511051003655 putative anticodon binding site; other site 511051003656 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 511051003657 motif 1; other site 511051003658 active site 511051003659 motif 2; other site 511051003660 motif 3; other site 511051003661 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511051003662 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511051003663 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511051003664 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 511051003665 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 511051003666 FMN binding site [chemical binding]; other site 511051003667 active site 511051003668 catalytic residues [active] 511051003669 substrate binding site [chemical binding]; other site 511051003670 Type III pantothenate kinase; Region: Pan_kinase; cl09130 511051003671 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 511051003672 intersubunit interface [polypeptide binding]; other site 511051003673 active site 511051003674 Zn2+ binding site [ion binding]; other site 511051003675 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051003676 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 511051003677 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 511051003678 oligomer interface [polypeptide binding]; other site 511051003679 putative active site [active] 511051003680 metal binding site [ion binding]; metal-binding site 511051003681 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051003682 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 511051003683 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 511051003684 G1 box; other site 511051003685 GTP/Mg2+ binding site [chemical binding]; other site 511051003686 G2 box; other site 511051003687 Switch I region; other site 511051003688 G3 box; other site 511051003689 Switch II region; other site 511051003690 G4 box; other site 511051003691 G5 box; other site 511051003692 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 511051003693 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 511051003694 ATP-binding site [chemical binding]; other site 511051003695 Sugar specificity; other site 511051003696 Pyrimidine base specificity; other site 511051003697 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051003698 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051003699 PLD-like domain; Region: PLDc_2; pfam13091 511051003700 putative active site [active] 511051003701 catalytic site [active] 511051003702 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051003703 PLD-like domain; Region: PLDc_2; pfam13091 511051003704 putative active site [active] 511051003705 catalytic site [active] 511051003706 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 511051003707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003708 dimer interface [polypeptide binding]; other site 511051003709 conserved gate region; other site 511051003710 putative PBP binding loops; other site 511051003711 ABC-ATPase subunit interface; other site 511051003712 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511051003713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003714 dimer interface [polypeptide binding]; other site 511051003715 conserved gate region; other site 511051003716 putative PBP binding loops; other site 511051003717 ABC-ATPase subunit interface; other site 511051003718 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051003719 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511051003720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051003721 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511051003722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051003723 Radical SAM superfamily; Region: Radical_SAM; pfam04055 511051003724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051003725 FeS/SAM binding site; other site 511051003726 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 511051003727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051003728 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 511051003729 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 511051003730 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 511051003731 ribosomal protein L20; Region: rpl20; CHL00068 511051003732 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 511051003733 23S rRNA binding site [nucleotide binding]; other site 511051003734 L21 binding site [polypeptide binding]; other site 511051003735 L13 binding site [polypeptide binding]; other site 511051003736 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 511051003737 translation initiation factor IF-3; Region: infC; TIGR00168 511051003738 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 511051003739 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 511051003740 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 511051003741 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 511051003742 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 511051003743 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 511051003744 active site 511051003745 dimer interface [polypeptide binding]; other site 511051003746 motif 1; other site 511051003747 motif 2; other site 511051003748 motif 3; other site 511051003749 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 511051003750 anticodon binding site; other site 511051003751 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 511051003752 Phosphate transporter family; Region: PHO4; cl00396 511051003753 DNA topoisomerase III; Validated; Region: PRK08173 511051003754 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 511051003755 active site 511051003756 putative interdomain interaction site [polypeptide binding]; other site 511051003757 putative metal-binding site [ion binding]; other site 511051003758 putative nucleotide binding site [chemical binding]; other site 511051003759 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511051003760 domain I; other site 511051003761 DNA binding groove [nucleotide binding] 511051003762 phosphate binding site [ion binding]; other site 511051003763 domain II; other site 511051003764 domain III; other site 511051003765 nucleotide binding site [chemical binding]; other site 511051003766 catalytic site [active] 511051003767 domain IV; other site 511051003768 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 511051003769 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 511051003770 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 511051003771 DNA-binding site [nucleotide binding]; DNA binding site 511051003772 RNA-binding motif; other site 511051003773 recombination factor protein RarA; Reviewed; Region: PRK13342 511051003774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051003775 Walker A motif; other site 511051003776 ATP binding site [chemical binding]; other site 511051003777 Walker B motif; other site 511051003778 arginine finger; other site 511051003779 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511051003780 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 511051003781 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 511051003782 active site 511051003783 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 511051003784 S-layer homology domain; Region: SLH; pfam00395 511051003785 S-layer homology domain; Region: SLH; pfam00395 511051003786 S-layer homology domain; Region: SLH; pfam00395 511051003787 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051003788 NAD-dependent deacetylase; Provisional; Region: PRK00481 511051003789 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 511051003790 NAD+ binding site [chemical binding]; other site 511051003791 substrate binding site [chemical binding]; other site 511051003792 Zn binding site [ion binding]; other site 511051003793 Tetratricopeptide repeat; Region: TPR_12; pfam13424 511051003794 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 511051003795 Tetratricopeptide repeat; Region: TPR_12; pfam13424 511051003796 KIF-1 binding protein C terminal; Region: KBP_C; pfam12309 511051003797 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 511051003798 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 511051003799 Walker A/P-loop; other site 511051003800 ATP binding site [chemical binding]; other site 511051003801 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 511051003802 ABC transporter signature motif; other site 511051003803 Walker B; other site 511051003804 D-loop; other site 511051003805 H-loop/switch region; other site 511051003806 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 511051003807 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 511051003808 Potassium binding sites [ion binding]; other site 511051003809 Cesium cation binding sites [ion binding]; other site 511051003810 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 511051003811 iron-sulfur cluster [ion binding]; other site 511051003812 [2Fe-2S] cluster binding site [ion binding]; other site 511051003813 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 511051003814 hydrophobic ligand binding site; other site 511051003815 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511051003816 endonuclease III; Region: ENDO3c; smart00478 511051003817 minor groove reading motif; other site 511051003818 helix-hairpin-helix signature motif; other site 511051003819 substrate binding pocket [chemical binding]; other site 511051003820 active site 511051003821 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 511051003822 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 511051003823 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 511051003824 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 511051003825 generic binding surface II; other site 511051003826 generic binding surface I; other site 511051003827 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 511051003828 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 511051003829 putative NAD(P) binding site [chemical binding]; other site 511051003830 putative active site [active] 511051003831 Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739 511051003832 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 511051003833 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 511051003834 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511051003835 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511051003836 catalytic residue [active] 511051003837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051003838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051003839 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 511051003840 EamA-like transporter family; Region: EamA; cl01037 511051003841 EamA-like transporter family; Region: EamA; cl01037 511051003842 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 511051003843 active site 511051003844 catalytic triad [active] 511051003845 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 511051003846 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 511051003847 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511051003848 translation initiation factor IF-2; Region: IF-2; TIGR00487 511051003849 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 511051003850 G1 box; other site 511051003851 putative GEF interaction site [polypeptide binding]; other site 511051003852 GTP/Mg2+ binding site [chemical binding]; other site 511051003853 Switch I region; other site 511051003854 G2 box; other site 511051003855 G3 box; other site 511051003856 Switch II region; other site 511051003857 G4 box; other site 511051003858 G5 box; other site 511051003859 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 511051003860 Translation-initiation factor 2; Region: IF-2; pfam11987 511051003861 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 511051003862 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 511051003863 NusA N-terminal domain; Region: NusA_N; pfam08529 511051003864 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 511051003865 RNA binding site [nucleotide binding]; other site 511051003866 homodimer interface [polypeptide binding]; other site 511051003867 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 511051003868 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511051003869 G-X-X-G motif; other site 511051003870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 511051003871 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 511051003872 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 511051003873 trimer interface [polypeptide binding]; other site 511051003874 active site 511051003875 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511051003876 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511051003877 Esterase/lipase [General function prediction only]; Region: COG1647 511051003878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051003879 S-adenosylmethionine binding site [chemical binding]; other site 511051003880 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 511051003881 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 511051003882 active site 511051003883 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 511051003884 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 511051003885 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 511051003886 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 511051003887 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 511051003888 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 511051003889 Walker A motif; other site 511051003890 ATP binding site [chemical binding]; other site 511051003891 Walker B motif; other site 511051003892 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 511051003893 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 511051003894 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 511051003895 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 511051003896 putative active site [active] 511051003897 catalytic residue [active] 511051003898 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 511051003899 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 511051003900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051003901 ATP binding site [chemical binding]; other site 511051003902 putative Mg++ binding site [ion binding]; other site 511051003903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051003904 nucleotide binding region [chemical binding]; other site 511051003905 ATP-binding site [chemical binding]; other site 511051003906 TRCF domain; Region: TRCF; cl04088 511051003907 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 511051003908 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 511051003909 homodimer interface [polypeptide binding]; other site 511051003910 metal binding site [ion binding]; metal-binding site 511051003911 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 511051003912 homodimer interface [polypeptide binding]; other site 511051003913 active site 511051003914 putative chemical substrate binding site [chemical binding]; other site 511051003915 metal binding site [ion binding]; metal-binding site 511051003916 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 511051003917 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 511051003918 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051003919 active site 511051003920 metal binding site [ion binding]; metal-binding site 511051003921 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 511051003922 active site 511051003923 dimerization interface [polypeptide binding]; other site 511051003924 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 511051003925 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 511051003926 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 511051003927 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511051003928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051003929 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 511051003930 putative active site; other site 511051003931 putative metal binding residues [ion binding]; other site 511051003932 signature motif; other site 511051003933 putative triphosphate binding site [ion binding]; other site 511051003934 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 511051003935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051003936 glutamate formiminotransferase; Region: FtcD; TIGR02024 511051003937 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 511051003938 Formiminotransferase domain; Region: FTCD; pfam02971 511051003939 imidazolonepropionase; Validated; Region: PRK09356 511051003940 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 511051003941 active site 511051003942 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 511051003943 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 511051003944 aspartate aminotransferase; Provisional; Region: PRK05764 511051003945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511051003946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051003947 homodimer interface [polypeptide binding]; other site 511051003948 catalytic residue [active] 511051003949 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511051003950 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 511051003951 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 511051003952 active site 511051003953 nucleophile elbow; other site 511051003954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051003955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051003956 putative substrate translocation pore; other site 511051003957 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 511051003958 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 511051003959 active site 511051003960 HIGH motif; other site 511051003961 dimer interface [polypeptide binding]; other site 511051003962 KMSKS motif; other site 511051003963 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511051003964 RNA binding surface [nucleotide binding]; other site 511051003965 ferric uptake regulator; Provisional; Region: fur; PRK09462 511051003966 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511051003967 metal binding site 2 [ion binding]; metal-binding site 511051003968 putative DNA binding helix; other site 511051003969 metal binding site 1 [ion binding]; metal-binding site 511051003970 dimer interface [polypeptide binding]; other site 511051003971 structural Zn2+ binding site [ion binding]; other site 511051003972 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 511051003973 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511051003974 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511051003975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003976 dimer interface [polypeptide binding]; other site 511051003977 conserved gate region; other site 511051003978 putative PBP binding loops; other site 511051003979 ABC-ATPase subunit interface; other site 511051003980 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511051003981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051003982 Walker A/P-loop; other site 511051003983 ATP binding site [chemical binding]; other site 511051003984 Q-loop/lid; other site 511051003985 ABC transporter signature motif; other site 511051003986 Walker B; other site 511051003987 D-loop; other site 511051003988 H-loop/switch region; other site 511051003989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003990 dimer interface [polypeptide binding]; other site 511051003991 conserved gate region; other site 511051003992 putative PBP binding loops; other site 511051003993 ABC-ATPase subunit interface; other site 511051003994 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511051003995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511051003996 substrate binding pocket [chemical binding]; other site 511051003997 membrane-bound complex binding site; other site 511051003998 hinge residues; other site 511051003999 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 511051004000 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051004001 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051004002 DNA binding residues [nucleotide binding] 511051004003 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511051004004 Sporulation and spore germination; Region: Germane; cl11253 511051004005 Sporulation and spore germination; Region: Germane; cl11253 511051004006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051004007 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 511051004008 active site 511051004009 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 511051004010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051004011 Walker A motif; other site 511051004012 ATP binding site [chemical binding]; other site 511051004013 Walker B motif; other site 511051004014 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 511051004015 MPT binding site; other site 511051004016 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 511051004017 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511051004018 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511051004019 photolyase PhrII; Region: phr2; TIGR00591 511051004020 DNA photolyase; Region: DNA_photolyase; pfam00875 511051004021 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 511051004022 Protein of unknown function (DUF523); Region: DUF523; cl00733 511051004023 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 511051004024 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 511051004025 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 511051004026 active site 511051004027 (T/H)XGH motif; other site 511051004028 GTPase CgtA; Reviewed; Region: obgE; PRK12297 511051004029 GTP1/OBG; Region: GTP1_OBG; pfam01018 511051004030 Obg GTPase; Region: Obg; cd01898 511051004031 G1 box; other site 511051004032 GTP/Mg2+ binding site [chemical binding]; other site 511051004033 Switch I region; other site 511051004034 G2 box; other site 511051004035 G3 box; other site 511051004036 Switch II region; other site 511051004037 G4 box; other site 511051004038 G5 box; other site 511051004039 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 511051004040 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 511051004041 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 511051004042 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004043 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511051004044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051004045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004046 dimer interface [polypeptide binding]; other site 511051004047 conserved gate region; other site 511051004048 putative PBP binding loops; other site 511051004049 ABC-ATPase subunit interface; other site 511051004050 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 511051004051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004052 putative PBP binding loops; other site 511051004053 ABC-ATPase subunit interface; other site 511051004054 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 511051004055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051004056 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 511051004057 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 511051004058 Metal-binding active site; metal-binding site 511051004059 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511051004060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051004061 Walker A/P-loop; other site 511051004062 ATP binding site [chemical binding]; other site 511051004063 Q-loop/lid; other site 511051004064 ABC transporter signature motif; other site 511051004065 Walker B; other site 511051004066 D-loop; other site 511051004067 H-loop/switch region; other site 511051004068 TOBE domain; Region: TOBE_2; cl01440 511051004069 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 511051004070 classical (c) SDRs; Region: SDR_c; cd05233 511051004071 NAD(P) binding site [chemical binding]; other site 511051004072 active site 511051004073 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511051004074 Helix-turn-helix domains; Region: HTH; cl00088 511051004075 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 511051004076 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 511051004077 active site 511051004078 dimerization interface [polypeptide binding]; other site 511051004079 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 511051004080 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 511051004081 active site 511051004082 metal binding site [ion binding]; metal-binding site 511051004083 amino acid transporter; Region: 2A0306; TIGR00909 511051004084 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 511051004085 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 511051004086 N- and C-terminal domain interface [polypeptide binding]; other site 511051004087 putative active site [active] 511051004088 catalytic site [active] 511051004089 metal binding site [ion binding]; metal-binding site 511051004090 putative xylulose binding site [chemical binding]; other site 511051004091 putative ATP binding site [chemical binding]; other site 511051004092 putative homodimer interface [polypeptide binding]; other site 511051004093 BtpA family; Region: BtpA; cl00440 511051004094 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 511051004095 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 511051004096 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511051004097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051004098 Walker A/P-loop; other site 511051004099 ATP binding site [chemical binding]; other site 511051004100 Q-loop/lid; other site 511051004101 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511051004102 ABC transporter; Region: ABC_tran_2; pfam12848 511051004103 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511051004104 serine O-acetyltransferase; Region: cysE; TIGR01172 511051004105 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 511051004106 trimer interface [polypeptide binding]; other site 511051004107 active site 511051004108 substrate binding site [chemical binding]; other site 511051004109 CoA binding site [chemical binding]; other site 511051004110 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 511051004111 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 511051004112 dimer interface [polypeptide binding]; other site 511051004113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051004114 catalytic residue [active] 511051004115 Sugar fermentation stimulation protein; Region: SfsA; cl00647 511051004116 Protein of unknown function DUF72; Region: DUF72; cl00777 511051004117 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 511051004118 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 511051004119 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 511051004120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004121 FeS/SAM binding site; other site 511051004122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051004123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511051004124 dimerization interface [polypeptide binding]; other site 511051004125 putative DNA binding site [nucleotide binding]; other site 511051004126 putative Zn2+ binding site [ion binding]; other site 511051004127 Protein of unknown function (DUF996); Region: DUF996; cl00970 511051004128 Protein of unknown function (DUF996); Region: DUF996; cl00970 511051004129 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 511051004130 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 511051004131 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 511051004132 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511051004133 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511051004134 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 511051004135 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 511051004136 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 511051004137 Uncharacterized conserved protein [Function unknown]; Region: COG1542 511051004138 Protein of unknown function (DUF505); Region: DUF505; pfam04458 511051004139 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051004140 Zn2+ binding site [ion binding]; other site 511051004141 Mg2+ binding site [ion binding]; other site 511051004142 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511051004143 amidase catalytic site [active] 511051004144 Zn binding residues [ion binding]; other site 511051004145 substrate binding site [chemical binding]; other site 511051004146 S-layer homology domain; Region: SLH; pfam00395 511051004147 YvrJ protein family; Region: YvrJ; pfam12841 511051004148 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 511051004149 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511051004150 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511051004151 substrate binding site [chemical binding]; other site 511051004152 dimer interface [polypeptide binding]; other site 511051004153 ATP binding site [chemical binding]; other site 511051004154 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 511051004155 active site 511051004156 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 511051004157 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 511051004158 ligand binding site [chemical binding]; other site 511051004159 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 511051004160 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 511051004161 Walker A/P-loop; other site 511051004162 ATP binding site [chemical binding]; other site 511051004163 Q-loop/lid; other site 511051004164 ABC transporter signature motif; other site 511051004165 Walker B; other site 511051004166 D-loop; other site 511051004167 H-loop/switch region; other site 511051004168 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 511051004169 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051004170 TM-ABC transporter signature motif; other site 511051004171 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051004172 TM-ABC transporter signature motif; other site 511051004173 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 511051004174 active site 511051004175 tetramer interface [polypeptide binding]; other site 511051004176 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 511051004177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051004178 Family description; Region: UvrD_C_2; cl15862 511051004179 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 511051004180 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 511051004181 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 511051004182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004183 FeS/SAM binding site; other site 511051004184 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 511051004185 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 511051004186 nucleotide binding site/active site [active] 511051004187 HIT family signature motif; other site 511051004188 catalytic residue [active] 511051004189 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 511051004190 Cl- selectivity filter; other site 511051004191 Cl- binding residues [ion binding]; other site 511051004192 pore gating glutamate residue; other site 511051004193 dimer interface [polypeptide binding]; other site 511051004194 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 511051004195 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 511051004196 Helix-turn-helix domains; Region: HTH; cl00088 511051004197 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 511051004198 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511051004199 DXD motif; other site 511051004200 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511051004201 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 511051004202 4Fe-4S binding domain; Region: Fer4_5; pfam12801 511051004203 Uncharacterized conserved protein [Function unknown]; Region: COG3461 511051004204 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 511051004205 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511051004206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511051004207 non-specific DNA binding site [nucleotide binding]; other site 511051004208 salt bridge; other site 511051004209 sequence-specific DNA binding site [nucleotide binding]; other site 511051004210 Domain of unknown function (DUF955); Region: DUF955; cl01076 511051004211 CTP synthetase; Validated; Region: pyrG; PRK05380 511051004212 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 511051004213 Catalytic site [active] 511051004214 active site 511051004215 UTP binding site [chemical binding]; other site 511051004216 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 511051004217 active site 511051004218 putative oxyanion hole; other site 511051004219 catalytic triad [active] 511051004220 short chain dehydrogenase; Validated; Region: PRK06182 511051004221 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 511051004222 NADP binding site [chemical binding]; other site 511051004223 active site 511051004224 steroid binding site; other site 511051004225 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 511051004226 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 511051004227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 511051004228 Predicted dehydrogenase [General function prediction only]; Region: COG0579 511051004229 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 511051004230 glycerol kinase; Provisional; Region: glpK; PRK00047 511051004231 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 511051004232 N- and C-terminal domain interface [polypeptide binding]; other site 511051004233 putative active site [active] 511051004234 putative MgATP binding site [chemical binding]; other site 511051004235 catalytic site [active] 511051004236 metal binding site [ion binding]; metal-binding site 511051004237 putative homotetramer interface [polypeptide binding]; other site 511051004238 putative glycerol binding site [chemical binding]; other site 511051004239 homodimer interface [polypeptide binding]; other site 511051004240 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511051004241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051004242 Walker A/P-loop; other site 511051004243 ATP binding site [chemical binding]; other site 511051004244 Q-loop/lid; other site 511051004245 ABC transporter signature motif; other site 511051004246 Walker B; other site 511051004247 D-loop; other site 511051004248 H-loop/switch region; other site 511051004249 TOBE domain; Region: TOBE_2; cl01440 511051004250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004251 dimer interface [polypeptide binding]; other site 511051004252 conserved gate region; other site 511051004253 putative PBP binding loops; other site 511051004254 ABC-ATPase subunit interface; other site 511051004255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 511051004256 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 511051004257 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511051004258 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511051004259 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 511051004260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051004261 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511051004262 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 511051004263 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 511051004264 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 511051004265 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 511051004266 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511051004267 dimerization domain swap beta strand [polypeptide binding]; other site 511051004268 regulatory protein interface [polypeptide binding]; other site 511051004269 active site 511051004270 regulatory phosphorylation site [posttranslational modification]; other site 511051004271 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511051004272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051004273 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 511051004274 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 511051004275 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 511051004276 active site 511051004277 P-loop; other site 511051004278 phosphorylation site [posttranslational modification] 511051004279 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511051004280 active site 511051004281 phosphorylation site [posttranslational modification] 511051004282 Helix-turn-helix domains; Region: HTH; cl00088 511051004283 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 511051004284 Helix-turn-helix domains; Region: HTH; cl00088 511051004285 PRD domain; Region: PRD; cl15445 511051004286 PRD domain; Region: PRD; cl15445 511051004287 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 511051004288 active site 511051004289 P-loop; other site 511051004290 phosphorylation site [posttranslational modification] 511051004291 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511051004292 active site 511051004293 phosphorylation site [posttranslational modification] 511051004294 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051004295 tyrosine 3-monooxygenase, tetrameric; Region: Tyr_3_monoox; TIGR01269 511051004296 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 511051004297 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 511051004298 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511051004299 DXD motif; other site 511051004300 Adenosine specific kinase; Region: Adenosine_kin; cl00796 511051004301 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 511051004302 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 511051004303 active site 511051004304 Zn binding site [ion binding]; other site 511051004305 Predicted transcriptional regulator [Transcription]; Region: COG2345 511051004306 Helix-turn-helix domains; Region: HTH; cl00088 511051004307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004308 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 511051004309 FeS/SAM binding site; other site 511051004310 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 511051004311 Predicted integral membrane protein [Function unknown]; Region: COG0392 511051004312 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 511051004313 glutamate dehydrogenase; Provisional; Region: PRK09414 511051004314 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 511051004315 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 511051004316 NAD(P) binding site [chemical binding]; other site 511051004317 Helix-turn-helix domains; Region: HTH; cl00088 511051004318 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 511051004319 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 511051004320 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 511051004321 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 511051004322 G1 box; other site 511051004323 GTP/Mg2+ binding site [chemical binding]; other site 511051004324 Switch I region; other site 511051004325 G2 box; other site 511051004326 G3 box; other site 511051004327 Switch II region; other site 511051004328 G4 box; other site 511051004329 G5 box; other site 511051004330 Nucleoside recognition; Region: Gate; cl00486 511051004331 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 511051004332 Nucleoside recognition; Region: Gate; cl00486 511051004333 FeoA domain; Region: FeoA; cl00838 511051004334 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 511051004335 Spherulation-specific family 4; Region: Spherulin4; pfam12138 511051004336 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 511051004337 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 511051004338 active site 511051004339 putative substrate binding pocket [chemical binding]; other site 511051004340 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 511051004341 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 511051004342 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 511051004343 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 511051004344 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 511051004345 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 511051004346 Walker A motif; other site 511051004347 ATP binding site [chemical binding]; other site 511051004348 Walker B motif; other site 511051004349 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 511051004350 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 511051004351 Walker A motif; other site 511051004352 ATP binding site [chemical binding]; other site 511051004353 Walker B motif; other site 511051004354 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 511051004355 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 511051004356 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 511051004357 YcfA-like protein; Region: YcfA; cl00752 511051004358 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 511051004359 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051004360 TM-ABC transporter signature motif; other site 511051004361 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051004362 TM-ABC transporter signature motif; other site 511051004363 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 511051004364 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051004365 Walker A/P-loop; other site 511051004366 ATP binding site [chemical binding]; other site 511051004367 Q-loop/lid; other site 511051004368 ABC transporter signature motif; other site 511051004369 Walker B; other site 511051004370 D-loop; other site 511051004371 H-loop/switch region; other site 511051004372 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 511051004373 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 511051004374 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 511051004375 ligand binding site [chemical binding]; other site 511051004376 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 511051004377 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 511051004378 G1 box; other site 511051004379 GTP/Mg2+ binding site [chemical binding]; other site 511051004380 G2 box; other site 511051004381 Switch I region; other site 511051004382 G3 box; other site 511051004383 Switch II region; other site 511051004384 G4 box; other site 511051004385 G5 box; other site 511051004386 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051004387 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 511051004388 active site 511051004389 ADP/pyrophosphate binding site [chemical binding]; other site 511051004390 dimerization interface [polypeptide binding]; other site 511051004391 allosteric effector site; other site 511051004392 fructose-1,6-bisphosphate binding site; other site 511051004393 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 511051004394 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 511051004395 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 511051004396 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 511051004397 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 511051004398 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 511051004399 trmE is a tRNA modification GTPase; Region: trmE; cd04164 511051004400 G1 box; other site 511051004401 GTP/Mg2+ binding site [chemical binding]; other site 511051004402 Switch I region; other site 511051004403 G2 box; other site 511051004404 Switch II region; other site 511051004405 G3 box; other site 511051004406 G4 box; other site 511051004407 G5 box; other site 511051004408 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 511051004409 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 511051004410 G-X-X-G motif; other site 511051004411 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 511051004412 RxxxH motif; other site 511051004413 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 511051004414 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 511051004415 Haemolytic domain; Region: Haemolytic; cl00506 511051004416 Ribonuclease P; Region: Ribonuclease_P; cl00457 511051004417 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 511051004418 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 511051004419 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 511051004420 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 511051004421 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511051004422 carboxyltransferase (CT) interaction site; other site 511051004423 biotinylation site [posttranslational modification]; other site 511051004424 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 511051004425 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511051004426 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511051004427 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 511051004428 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511051004429 active site 511051004430 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 511051004431 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 511051004432 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 511051004433 Substrate-binding site [chemical binding]; other site 511051004434 Substrate specificity [chemical binding]; other site 511051004435 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 511051004436 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 511051004437 active site 511051004438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051004439 metal binding site [ion binding]; metal-binding site 511051004440 active site 511051004441 I-site; other site 511051004442 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 511051004443 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511051004444 DXD motif; other site 511051004445 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004446 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004447 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051004449 active site 511051004450 Protein of unknown function DUF86; Region: DUF86; cl01031 511051004451 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 511051004452 active site 511051004453 NTP binding site [chemical binding]; other site 511051004454 metal binding triad [ion binding]; metal-binding site 511051004455 antibiotic binding site [chemical binding]; other site 511051004456 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 511051004457 PspA/IM30 family; Region: PspA_IM30; pfam04012 511051004458 Peptidase family M23; Region: Peptidase_M23; pfam01551 511051004459 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 511051004460 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004461 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004462 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004463 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004464 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004465 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 511051004466 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 511051004467 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 511051004468 active site 511051004469 dimer interfaces [polypeptide binding]; other site 511051004470 catalytic residues [active] 511051004471 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051004472 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051004473 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 511051004474 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 511051004475 GIY-YIG motif/motif A; other site 511051004476 putative active site [active] 511051004477 putative metal binding site [ion binding]; other site 511051004478 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 511051004479 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511051004480 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 511051004481 putative active site [active] 511051004482 putative metal binding site [ion binding]; other site 511051004483 Helix-turn-helix domains; Region: HTH; cl00088 511051004484 O-Antigen ligase; Region: Wzy_C; cl04850 511051004485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511051004486 TPR motif; other site 511051004487 binding surface 511051004488 TPR repeat; Region: TPR_11; pfam13414 511051004489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511051004490 binding surface 511051004491 TPR motif; other site 511051004492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511051004493 binding surface 511051004494 TPR motif; other site 511051004495 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 511051004496 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 511051004497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051004498 NAD(P) binding site [chemical binding]; other site 511051004499 active site 511051004500 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 511051004501 active site 511051004502 NTP binding site [chemical binding]; other site 511051004503 metal binding triad [ion binding]; metal-binding site 511051004504 antibiotic binding site [chemical binding]; other site 511051004505 Protein of unknown function DUF86; Region: DUF86; cl01031 511051004506 Bacterial sugar transferase; Region: Bac_transf; cl00939 511051004507 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 511051004508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051004509 putative ADP-binding pocket [chemical binding]; other site 511051004510 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051004511 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 511051004512 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 511051004513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051004514 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 511051004515 putative ADP-binding pocket [chemical binding]; other site 511051004516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511051004517 active site 511051004518 Integrase core domain; Region: rve; cl01316 511051004519 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 511051004520 active site 511051004521 catalytic residues [active] 511051004522 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 511051004523 putative integrin binding motif; other site 511051004524 PA/protease domain interface [polypeptide binding]; other site 511051004525 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 511051004526 catalytic residues [active] 511051004527 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 511051004528 FlgD Ig-like domain; Region: FlgD_ig; cl15790 511051004529 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 511051004530 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 511051004531 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004532 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004533 Bacterial Ig-like domain; Region: Big_5; cl01012 511051004534 Bacterial Ig-like domain; Region: Big_5; cl01012 511051004535 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 511051004536 generic binding surface I; other site 511051004537 generic binding surface II; other site 511051004538 Bacterial Ig-like domain; Region: Big_5; cl01012 511051004539 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051004540 PLD-like domain; Region: PLDc_2; pfam13091 511051004541 putative active site [active] 511051004542 catalytic site [active] 511051004543 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051004544 PLD-like domain; Region: PLDc_2; pfam13091 511051004545 putative active site [active] 511051004546 catalytic site [active] 511051004547 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 511051004548 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004549 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004550 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 511051004551 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 511051004552 active site 511051004553 Zn binding site [ion binding]; other site 511051004554 EamA-like transporter family; Region: EamA; cl01037 511051004555 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 511051004556 MoaE interaction surface [polypeptide binding]; other site 511051004557 MoeB interaction surface [polypeptide binding]; other site 511051004558 thiocarboxylated glycine; other site 511051004559 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 511051004560 active site 511051004561 Uncharacterized conserved protein [Function unknown]; Region: COG3391 511051004562 NHL repeat; Region: NHL; pfam01436 511051004563 NHL repeat; Region: NHL; pfam01436 511051004564 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 511051004565 NHL repeat; Region: NHL; pfam01436 511051004566 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 511051004567 dockerin binding interface; other site 511051004568 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004569 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004570 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 511051004571 putative active site [active] 511051004572 catalytic triad [active] 511051004573 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 511051004574 PA/protease domain interface [polypeptide binding]; other site 511051004575 putative integrin binding motif; other site 511051004576 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 511051004577 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 511051004578 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 511051004579 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 511051004580 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 511051004581 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 511051004582 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051004583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051004584 Esterase/lipase [General function prediction only]; Region: COG1647 511051004585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511051004586 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 511051004587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051004588 active site 511051004589 phosphorylation site [posttranslational modification] 511051004590 intermolecular recognition site; other site 511051004591 dimerization interface [polypeptide binding]; other site 511051004592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051004593 Zn2+ binding site [ion binding]; other site 511051004594 Mg2+ binding site [ion binding]; other site 511051004595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 511051004596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051004597 dimer interface [polypeptide binding]; other site 511051004598 phosphorylation site [posttranslational modification] 511051004599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051004600 ATP binding site [chemical binding]; other site 511051004601 Mg2+ binding site [ion binding]; other site 511051004602 G-X-G motif; other site 511051004603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051004604 active site 511051004605 phosphorylation site [posttranslational modification] 511051004606 intermolecular recognition site; other site 511051004607 peroxiredoxin; Provisional; Region: PRK13189 511051004608 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 511051004609 dimer interface [polypeptide binding]; other site 511051004610 decamer (pentamer of dimers) interface [polypeptide binding]; other site 511051004611 catalytic triad [active] 511051004612 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 511051004613 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 511051004614 reverse gyrase; Reviewed; Region: PRK09401 511051004615 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051004616 ATP binding site [chemical binding]; other site 511051004617 putative Mg++ binding site [ion binding]; other site 511051004618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051004619 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 511051004620 active site 511051004621 metal binding site [ion binding]; metal-binding site 511051004622 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511051004623 domain I; other site 511051004624 DNA binding groove [nucleotide binding] 511051004625 phosphate binding site [ion binding]; other site 511051004626 domain II; other site 511051004627 domain III; other site 511051004628 nucleotide binding site [chemical binding]; other site 511051004629 catalytic site [active] 511051004630 domain IV; other site 511051004631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051004632 S-adenosylmethionine binding site [chemical binding]; other site 511051004633 YKOF-related Family; Region: Ykof; pfam07615 511051004634 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 511051004635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004636 FeS/SAM binding site; other site 511051004637 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 511051004638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004639 FeS/SAM binding site; other site 511051004640 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl15461 511051004641 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 511051004642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511051004643 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 511051004644 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 511051004645 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 511051004646 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 511051004647 Helix-turn-helix domains; Region: HTH; cl00088 511051004648 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 511051004649 active site 511051004650 metal binding site [ion binding]; metal-binding site 511051004651 homotetramer interface [polypeptide binding]; other site 511051004652 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511051004653 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511051004654 P-loop; other site 511051004655 Magnesium ion binding site [ion binding]; other site 511051004656 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511051004657 Magnesium ion binding site [ion binding]; other site 511051004658 ParB-like nuclease domain; Region: ParBc; cl02129 511051004659 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 511051004660 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 511051004661 Moco binding site; other site 511051004662 metal coordination site [ion binding]; other site 511051004663 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 511051004664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004665 FeS/SAM binding site; other site 511051004666 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 511051004667 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051004668 Zn2+ binding site [ion binding]; other site 511051004669 Mg2+ binding site [ion binding]; other site 511051004670 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051004671 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 511051004672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511051004673 FtsX-like permease family; Region: FtsX; cl15850 511051004674 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511051004675 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 511051004676 Walker A/P-loop; other site 511051004677 ATP binding site [chemical binding]; other site 511051004678 Q-loop/lid; other site 511051004679 ABC transporter signature motif; other site 511051004680 Walker B; other site 511051004681 D-loop; other site 511051004682 H-loop/switch region; other site 511051004683 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 511051004684 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 511051004685 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 511051004686 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11866 511051004687 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511051004688 TPP-binding site [chemical binding]; other site 511051004689 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 511051004690 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 511051004691 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 511051004692 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051004693 dimer interface [polypeptide binding]; other site 511051004694 PYR/PP interface [polypeptide binding]; other site 511051004695 TPP binding site [chemical binding]; other site 511051004696 substrate binding site [chemical binding]; other site 511051004697 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 511051004698 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 511051004699 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 511051004700 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 511051004701 DNA binding residues [nucleotide binding] 511051004702 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 511051004703 catalytic residues [active] 511051004704 catalytic nucleophile [active]