-- dump date 20120504_140634 -- class Genbank::misc_feature -- table misc_feature_note -- id note 306263000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 306263000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 306263000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263000004 Walker A motif; other site 306263000005 ATP binding site [chemical binding]; other site 306263000006 Walker B motif; other site 306263000007 arginine finger; other site 306263000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 306263000009 DnaA box-binding interface [nucleotide binding]; other site 306263000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 306263000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 306263000012 putative DNA binding surface [nucleotide binding]; other site 306263000013 dimer interface [polypeptide binding]; other site 306263000014 beta-clamp/clamp loader binding surface; other site 306263000015 beta-clamp/translesion DNA polymerase binding surface; other site 306263000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 306263000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 306263000018 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 306263000019 anchoring element; other site 306263000020 dimer interface [polypeptide binding]; other site 306263000021 ATP binding site [chemical binding]; other site 306263000022 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 306263000023 active site 306263000024 putative metal-binding site [ion binding]; other site 306263000025 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 306263000026 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 306263000027 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 306263000028 active site 306263000029 purine riboside binding site [chemical binding]; other site 306263000030 Protein of unknown function (DUF511); Region: DUF511; cl01114 306263000031 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 306263000032 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 306263000033 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 306263000034 Moco binding site; other site 306263000035 metal coordination site [ion binding]; other site 306263000036 dimerization interface [polypeptide binding]; other site 306263000037 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 306263000038 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 306263000039 PhnA protein; Region: PhnA; pfam03831 306263000040 Thymidylate synthase complementing protein; Region: Thy1; cl03630 306263000041 CTP synthetase; Validated; Region: pyrG; PRK05380 306263000042 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 306263000043 Catalytic site [active] 306263000044 active site 306263000045 UTP binding site [chemical binding]; other site 306263000046 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 306263000047 active site 306263000048 putative oxyanion hole; other site 306263000049 catalytic triad [active] 306263000050 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 306263000051 DHH family; Region: DHH; pfam01368 306263000052 DHHA1 domain; Region: DHHA1; pfam02272 306263000053 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 306263000054 N-acetyl-D-glucosamine binding site [chemical binding]; other site 306263000055 catalytic residue [active] 306263000056 peptide chain release factor 1; Validated; Region: prfA; PRK00591 306263000057 RF-1 domain; Region: RF-1; cl02875 306263000058 RF-1 domain; Region: RF-1; cl02875 306263000059 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 306263000060 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 306263000061 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 306263000062 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 306263000063 active site 306263000064 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 306263000065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 306263000066 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 306263000067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263000068 S-adenosylmethionine binding site [chemical binding]; other site 306263000069 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 306263000070 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 306263000071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000072 FeS/SAM binding site; other site 306263000073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 306263000074 FeS/SAM binding site; other site 306263000075 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306263000076 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 306263000077 active site 306263000078 adenylosuccinate lyase; Provisional; Region: PRK08470 306263000079 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 306263000080 tetramer interface [polypeptide binding]; other site 306263000081 active site 306263000082 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 306263000083 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 306263000084 ATP cone domain; Region: ATP-cone; pfam03477 306263000085 Class I ribonucleotide reductase; Region: RNR_I; cd01679 306263000086 active site 306263000087 dimer interface [polypeptide binding]; other site 306263000088 catalytic residues [active] 306263000089 effector binding site; other site 306263000090 R2 peptide binding site; other site 306263000091 OPT oligopeptide transporter protein; Region: OPT; cl14607 306263000092 Bacitracin resistance protein BacA; Region: BacA; cl00858 306263000093 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 306263000094 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 306263000095 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 306263000096 active site 306263000097 dimer interface [polypeptide binding]; other site 306263000098 motif 1; other site 306263000099 motif 2; other site 306263000100 motif 3; other site 306263000101 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 306263000102 anticodon binding site; other site 306263000103 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 306263000104 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 306263000105 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 306263000106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263000107 Predicted transcriptional regulator [Transcription]; Region: COG2378 306263000108 Helix-turn-helix domains; Region: HTH; cl00088 306263000109 WYL domain; Region: WYL; cl14852 306263000110 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 306263000111 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 306263000112 metal ion-dependent adhesion site (MIDAS); other site 306263000113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263000114 Walker A motif; other site 306263000115 ATP binding site [chemical binding]; other site 306263000116 Walker B motif; other site 306263000117 arginine finger; other site 306263000118 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 306263000119 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 306263000120 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 306263000121 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 306263000122 23S rRNA binding site [nucleotide binding]; other site 306263000123 L21 binding site [polypeptide binding]; other site 306263000124 L13 binding site [polypeptide binding]; other site 306263000125 DNA ligase; Provisional; Region: PRK09125 306263000126 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 306263000127 DNA binding site [nucleotide binding] 306263000128 active site 306263000129 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 306263000130 DNA binding site [nucleotide binding] 306263000131 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306263000132 dimer interface [polypeptide binding]; other site 306263000133 putative PBP binding regions; other site 306263000134 ABC-ATPase subunit interface; other site 306263000135 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 306263000136 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 306263000137 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306263000138 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 306263000139 intersubunit interface [polypeptide binding]; other site 306263000140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263000141 S-adenosylmethionine binding site [chemical binding]; other site 306263000142 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 306263000143 active site 306263000144 substrate binding pocket [chemical binding]; other site 306263000145 dimer interface [polypeptide binding]; other site 306263000146 Helix-turn-helix domains; Region: HTH; cl00088 306263000147 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 306263000148 putative metal dependent hydrolase; Provisional; Region: PRK11598 306263000149 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 306263000150 Sulfatase; Region: Sulfatase; cl10460 306263000151 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 306263000152 putative catalytic site [active] 306263000153 putative metal binding site [ion binding]; other site 306263000154 putative phosphate binding site [ion binding]; other site 306263000155 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 306263000156 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 306263000157 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 306263000158 ATP cone domain; Region: ATP-cone; pfam03477 306263000159 Class III ribonucleotide reductase; Region: RNR_III; cd01675 306263000160 effector binding site; other site 306263000161 active site 306263000162 Zn binding site [ion binding]; other site 306263000163 glycine loop; other site 306263000164 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 306263000165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000166 FeS/SAM binding site; other site 306263000167 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 306263000168 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 306263000169 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 306263000170 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 306263000171 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 306263000172 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 306263000173 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 306263000174 dimerization interface [polypeptide binding]; other site 306263000175 putative ATP binding site [chemical binding]; other site 306263000176 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 306263000177 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 306263000178 CoA-binding site [chemical binding]; other site 306263000179 ATP-binding [chemical binding]; other site 306263000180 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 306263000181 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 306263000182 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 306263000183 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 306263000184 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 306263000185 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 306263000186 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 306263000187 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 306263000188 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 306263000189 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 306263000190 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 306263000191 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 306263000192 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 306263000193 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 306263000194 putative translocon binding site; other site 306263000195 protein-rRNA interface [nucleotide binding]; other site 306263000196 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 306263000197 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 306263000198 G-X-X-G motif; other site 306263000199 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 306263000200 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 306263000201 23S rRNA interface [nucleotide binding]; other site 306263000202 5S rRNA interface [nucleotide binding]; other site 306263000203 putative antibiotic binding site [chemical binding]; other site 306263000204 L25 interface [polypeptide binding]; other site 306263000205 L27 interface [polypeptide binding]; other site 306263000206 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 306263000207 putative translocon interaction site; other site 306263000208 23S rRNA interface [nucleotide binding]; other site 306263000209 signal recognition particle (SRP54) interaction site; other site 306263000210 L23 interface [polypeptide binding]; other site 306263000211 trigger factor interaction site; other site 306263000212 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 306263000213 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 306263000214 KOW motif; Region: KOW; cl00354 306263000215 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 306263000216 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 306263000217 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 306263000218 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 306263000219 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 306263000220 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 306263000221 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 306263000222 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 306263000223 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 306263000224 5S rRNA interface [nucleotide binding]; other site 306263000225 23S rRNA interface [nucleotide binding]; other site 306263000226 L5 interface [polypeptide binding]; other site 306263000227 ribosomal protein S5; Validated; Region: rps5; CHL00138 306263000228 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 306263000229 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 306263000230 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 306263000231 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 306263000232 SecY translocase; Region: SecY; pfam00344 306263000233 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 306263000234 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 306263000235 active site 306263000236 homotetramer interface [polypeptide binding]; other site 306263000237 homodimer interface [polypeptide binding]; other site 306263000238 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 306263000239 non-heme iron binding site [ion binding]; other site 306263000240 dimer interface [polypeptide binding]; other site 306263000241 Rubrerythrin [Energy production and conversion]; Region: COG1592 306263000242 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 306263000243 binuclear metal center [ion binding]; other site 306263000244 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 306263000245 iron binding site [ion binding]; other site 306263000246 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 306263000247 putative active site [active] 306263000248 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 306263000249 RNA/DNA hybrid binding site [nucleotide binding]; other site 306263000250 active site 306263000251 Amino acid permease; Region: AA_permease; cl00524 306263000252 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 306263000253 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 306263000254 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 306263000255 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 306263000256 active site 306263000257 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 306263000258 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263000259 dimer interface [polypeptide binding]; other site 306263000260 putative CheW interface [polypeptide binding]; other site 306263000261 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 306263000262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263000263 metabolite-proton symporter; Region: 2A0106; TIGR00883 306263000264 putative substrate translocation pore; other site 306263000265 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 306263000266 rRNA binding site [nucleotide binding]; other site 306263000267 predicted 30S ribosome binding site; other site 306263000268 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 306263000269 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 306263000270 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 306263000271 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 306263000272 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 306263000273 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 306263000274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306263000275 RNA binding surface [nucleotide binding]; other site 306263000276 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 306263000277 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 306263000278 alphaNTD homodimer interface [polypeptide binding]; other site 306263000279 alphaNTD - beta interaction site [polypeptide binding]; other site 306263000280 alphaNTD - beta' interaction site [polypeptide binding]; other site 306263000281 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 306263000282 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 306263000283 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 306263000284 ATP phosphoribosyltransferase; Region: HisG; cl15266 306263000285 HisG, C-terminal domain; Region: HisG_C; cl06867 306263000286 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 306263000287 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 306263000288 NAD binding site [chemical binding]; other site 306263000289 dimerization interface [polypeptide binding]; other site 306263000290 product binding site; other site 306263000291 substrate binding site [chemical binding]; other site 306263000292 zinc binding site [ion binding]; other site 306263000293 catalytic residues [active] 306263000294 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 306263000295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263000296 active site 306263000297 motif I; other site 306263000298 motif II; other site 306263000299 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 306263000300 putative active site pocket [active] 306263000301 4-fold oligomerization interface [polypeptide binding]; other site 306263000302 metal binding residues [ion binding]; metal-binding site 306263000303 3-fold/trimer interface [polypeptide binding]; other site 306263000304 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 306263000305 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 306263000306 putative active site [active] 306263000307 oxyanion strand; other site 306263000308 catalytic triad [active] 306263000309 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 306263000310 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 306263000311 catalytic residues [active] 306263000312 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 306263000313 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 306263000314 substrate binding site [chemical binding]; other site 306263000315 glutamase interaction surface [polypeptide binding]; other site 306263000316 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 306263000317 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 306263000318 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 306263000319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263000320 dimer interface [polypeptide binding]; other site 306263000321 putative CheW interface [polypeptide binding]; other site 306263000322 LabA_like proteins; Region: LabA_like; cd06167 306263000323 putative metal binding site [ion binding]; other site 306263000324 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 306263000325 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 306263000326 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 306263000327 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 306263000328 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263000329 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 306263000330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263000331 putative substrate translocation pore; other site 306263000332 NifU-like domain; Region: NifU; cl00484 306263000333 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 306263000334 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263000335 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306263000336 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 306263000337 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 306263000338 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 306263000339 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 306263000340 substrate binding pocket [chemical binding]; other site 306263000341 chain length determination region; other site 306263000342 substrate-Mg2+ binding site; other site 306263000343 catalytic residues [active] 306263000344 aspartate-rich region 1; other site 306263000345 active site lid residues [active] 306263000346 aspartate-rich region 2; other site 306263000347 transketolase; Reviewed; Region: PRK05899 306263000348 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 306263000349 TPP-binding site [chemical binding]; other site 306263000350 dimer interface [polypeptide binding]; other site 306263000351 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 306263000352 PYR/PP interface [polypeptide binding]; other site 306263000353 dimer interface [polypeptide binding]; other site 306263000354 TPP binding site [chemical binding]; other site 306263000355 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 306263000356 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 306263000357 anti sigma factor interaction site; other site 306263000358 regulatory phosphorylation site [posttranslational modification]; other site 306263000359 Permease; Region: Permease; cl00510 306263000360 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 306263000361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263000362 Walker A/P-loop; other site 306263000363 ATP binding site [chemical binding]; other site 306263000364 Q-loop/lid; other site 306263000365 ABC transporter signature motif; other site 306263000366 Walker B; other site 306263000367 D-loop; other site 306263000368 H-loop/switch region; other site 306263000369 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 306263000370 mce related protein; Region: MCE; cl15431 306263000371 Protein of unknown function (DUF330); Region: DUF330; cl01135 306263000372 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 306263000373 E-class dimer interface [polypeptide binding]; other site 306263000374 P-class dimer interface [polypeptide binding]; other site 306263000375 active site 306263000376 Cu2+ binding site [ion binding]; other site 306263000377 Zn2+ binding site [ion binding]; other site 306263000378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 306263000379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 306263000380 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 306263000381 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 306263000382 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 306263000383 ligand binding site [chemical binding]; other site 306263000384 active site 306263000385 UGI interface [polypeptide binding]; other site 306263000386 catalytic site [active] 306263000387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 306263000388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263000389 ATP binding site [chemical binding]; other site 306263000390 Mg2+ binding site [ion binding]; other site 306263000391 G-X-G motif; other site 306263000392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263000393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263000394 active site 306263000395 phosphorylation site [posttranslational modification] 306263000396 intermolecular recognition site; other site 306263000397 dimerization interface [polypeptide binding]; other site 306263000398 Helix-turn-helix domains; Region: HTH; cl00088 306263000399 DNA binding site [nucleotide binding] 306263000400 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 306263000401 Protein of unknown function (DUF541); Region: SIMPL; cl01077 306263000402 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 306263000403 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 306263000404 minor groove reading motif; other site 306263000405 helix-hairpin-helix signature motif; other site 306263000406 substrate binding pocket [chemical binding]; other site 306263000407 active site 306263000408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000409 FeS/SAM binding site; other site 306263000410 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 306263000411 SprA-related family; Region: SprA-related; pfam12118 306263000412 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 306263000413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263000414 NAD(P) binding pocket [chemical binding]; other site 306263000415 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 306263000416 Cation transport protein; Region: TrkH; cl10514 306263000417 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 306263000418 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 306263000419 Aspartase; Region: Aspartase; cd01357 306263000420 active sites [active] 306263000421 tetramer interface [polypeptide binding]; other site 306263000422 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263000423 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263000424 dimer interface [polypeptide binding]; other site 306263000425 putative CheW interface [polypeptide binding]; other site 306263000426 Protein of unknown function (DUF493); Region: DUF493; cl01102 306263000427 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 306263000428 trimer interface [polypeptide binding]; other site 306263000429 dimer interface [polypeptide binding]; other site 306263000430 putative active site [active] 306263000431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263000432 metabolite-proton symporter; Region: 2A0106; TIGR00883 306263000433 putative substrate translocation pore; other site 306263000434 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 306263000435 apolar tunnel; other site 306263000436 heme binding site [chemical binding]; other site 306263000437 dimerization interface [polypeptide binding]; other site 306263000438 AMIN domain; Region: AMIN; pfam11741 306263000439 enolase; Provisional; Region: eno; PRK00077 306263000440 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 306263000441 dimer interface [polypeptide binding]; other site 306263000442 metal binding site [ion binding]; metal-binding site 306263000443 substrate binding pocket [chemical binding]; other site 306263000444 recombinase A; Provisional; Region: recA; PRK09354 306263000445 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 306263000446 hexamer interface [polypeptide binding]; other site 306263000447 Walker A motif; other site 306263000448 ATP binding site [chemical binding]; other site 306263000449 Walker B motif; other site 306263000450 NMT1-like family; Region: NMT1_2; cl15260 306263000451 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 306263000452 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 306263000453 FAD binding domain; Region: FAD_binding_4; pfam01565 306263000454 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 306263000455 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 306263000456 active site 306263000457 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 306263000458 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 306263000459 biotin synthase; Provisional; Region: PRK08508 306263000460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000461 FeS/SAM binding site; other site 306263000462 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 306263000463 DNA topoisomerase I; Validated; Region: PRK05582 306263000464 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 306263000465 active site 306263000466 interdomain interaction site; other site 306263000467 putative metal-binding site [ion binding]; other site 306263000468 nucleotide binding site [chemical binding]; other site 306263000469 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 306263000470 domain I; other site 306263000471 DNA binding groove [nucleotide binding] 306263000472 phosphate binding site [ion binding]; other site 306263000473 domain II; other site 306263000474 domain III; other site 306263000475 nucleotide binding site [chemical binding]; other site 306263000476 catalytic site [active] 306263000477 domain IV; other site 306263000478 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 306263000479 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 306263000480 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 306263000481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000482 flagellin; Provisional; Region: PRK13589 306263000483 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 306263000484 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 306263000485 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 306263000486 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 306263000487 flagellin; Reviewed; Region: PRK08411 306263000488 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 306263000489 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 306263000490 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 306263000491 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 306263000492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000496 pseudaminic acid synthase; Region: PseI; TIGR03586 306263000497 NeuB family; Region: NeuB; cl00496 306263000498 SAF domain; Region: SAF; cl00555 306263000499 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 306263000500 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 306263000501 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 306263000502 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 306263000503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263000504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263000505 active site 306263000506 phosphorylation site [posttranslational modification] 306263000507 intermolecular recognition site; other site 306263000508 dimerization interface [polypeptide binding]; other site 306263000509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306263000510 DNA binding site [nucleotide binding] 306263000511 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 306263000512 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 306263000513 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 306263000514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 306263000515 TolB amino-terminal domain; Region: TolB_N; cl00639 306263000516 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 306263000517 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 306263000518 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 306263000519 GTPase CgtA; Reviewed; Region: obgE; PRK12299 306263000520 GTP1/OBG; Region: GTP1_OBG; pfam01018 306263000521 Obg GTPase; Region: Obg; cd01898 306263000522 G1 box; other site 306263000523 GTP/Mg2+ binding site [chemical binding]; other site 306263000524 Switch I region; other site 306263000525 G2 box; other site 306263000526 G3 box; other site 306263000527 Switch II region; other site 306263000528 G4 box; other site 306263000529 G5 box; other site 306263000530 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 306263000531 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 306263000532 putative active site [active] 306263000533 substrate binding site [chemical binding]; other site 306263000534 putative cosubstrate binding site; other site 306263000535 catalytic site [active] 306263000536 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 306263000537 substrate binding site [chemical binding]; other site 306263000538 biotin--protein ligase; Provisional; Region: PRK08477 306263000539 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 306263000540 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 306263000541 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306263000542 P-loop; other site 306263000543 Magnesium ion binding site [ion binding]; other site 306263000544 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306263000545 Magnesium ion binding site [ion binding]; other site 306263000546 ParB-like partition proteins; Region: parB_part; TIGR00180 306263000547 ParB-like nuclease domain; Region: ParBc; cl02129 306263000548 Plant ATP synthase F0; Region: YMF19; cl07975 306263000549 Plant ATP synthase F0; Region: YMF19; cl07975 306263000550 Plant ATP synthase F0; Region: YMF19; cl07975 306263000551 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 306263000552 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 306263000553 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 306263000554 beta subunit interaction interface [polypeptide binding]; other site 306263000555 Walker A motif; other site 306263000556 ATP binding site [chemical binding]; other site 306263000557 Walker B motif; other site 306263000558 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 306263000559 ATP synthase; Region: ATP-synt; cl00365 306263000560 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 306263000561 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 306263000562 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 306263000563 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 306263000564 alpha subunit interaction interface [polypeptide binding]; other site 306263000565 Walker A motif; other site 306263000566 ATP binding site [chemical binding]; other site 306263000567 Walker B motif; other site 306263000568 inhibitor binding site; inhibition site 306263000569 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 306263000570 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 306263000571 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 306263000572 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 306263000573 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 306263000574 Gram-negative bacterial tonB protein; Region: TonB; cl10048 306263000575 translocation protein TolB; Provisional; Region: tolB; PRK04043 306263000576 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 306263000577 ligand binding site [chemical binding]; other site 306263000578 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 306263000579 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 306263000580 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 306263000581 Acyl transferase domain; Region: Acyl_transf_1; cl08282 306263000582 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 306263000583 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 306263000584 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 306263000585 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 306263000586 Ligand Binding Site [chemical binding]; other site 306263000587 Isochorismatase family; Region: Isochorismatase; pfam00857 306263000588 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 306263000589 catalytic triad [active] 306263000590 conserved cis-peptide bond; other site 306263000591 Recombination protein O N terminal; Region: RecO_N; cl15812 306263000592 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 306263000593 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 306263000594 FMN binding site [chemical binding]; other site 306263000595 active site 306263000596 catalytic residues [active] 306263000597 substrate binding site [chemical binding]; other site 306263000598 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 306263000599 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 306263000600 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 306263000601 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 306263000602 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 306263000603 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 306263000604 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 306263000605 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 306263000606 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 306263000607 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 306263000608 Surface antigen; Region: Bac_surface_Ag; cl03097 306263000609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263000610 Prephenate dehydrogenase; Region: PDH; pfam02153 306263000611 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263000612 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 306263000613 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 306263000614 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 306263000615 homoserine kinase; Provisional; Region: PRK01212 306263000616 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 306263000617 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 306263000618 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 306263000619 translation initiation factor IF-2; Region: IF-2; TIGR00487 306263000620 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 306263000621 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 306263000622 G1 box; other site 306263000623 putative GEF interaction site [polypeptide binding]; other site 306263000624 GTP/Mg2+ binding site [chemical binding]; other site 306263000625 Switch I region; other site 306263000626 G2 box; other site 306263000627 G3 box; other site 306263000628 Switch II region; other site 306263000629 G4 box; other site 306263000630 G5 box; other site 306263000631 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 306263000632 Translation-initiation factor 2; Region: IF-2; pfam11987 306263000633 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 306263000634 Ribosome-binding factor A; Region: RBFA; cl00542 306263000635 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 306263000636 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 306263000637 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 306263000638 Sm1 motif; other site 306263000639 D3 - B interaction site; other site 306263000640 D1 - D2 interaction site; other site 306263000641 Hfq - Hfq interaction site; other site 306263000642 RNA binding pocket [nucleotide binding]; other site 306263000643 Sm2 motif; other site 306263000644 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 306263000645 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 306263000646 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 306263000647 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 306263000648 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 306263000649 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 306263000650 catalytic motif [active] 306263000651 Zn binding site [ion binding]; other site 306263000652 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 306263000653 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 306263000654 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 306263000655 tandem repeat interface [polypeptide binding]; other site 306263000656 oligomer interface [polypeptide binding]; other site 306263000657 active site residues [active] 306263000658 chlorohydrolase; Provisional; Region: PRK08418 306263000659 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 306263000660 active site 306263000661 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 306263000662 trimer interface [polypeptide binding]; other site 306263000663 active site 306263000664 dimer interface [polypeptide binding]; other site 306263000665 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 306263000666 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 306263000667 active site 306263000668 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 306263000669 catalytic center binding site [active] 306263000670 ATP binding site [chemical binding]; other site 306263000671 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 306263000672 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263000673 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 306263000674 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 306263000675 P-loop; other site 306263000676 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 306263000677 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 306263000678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306263000679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306263000680 DNA binding residues [nucleotide binding] 306263000681 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 306263000682 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 306263000683 flagellar motor switch protein FliY; Validated; Region: PRK08432 306263000684 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 306263000685 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 306263000686 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 306263000687 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 306263000688 Ligand Binding Site [chemical binding]; other site 306263000689 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 306263000690 tetramer interfaces [polypeptide binding]; other site 306263000691 binuclear metal-binding site [ion binding]; other site 306263000692 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 306263000693 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263000694 active site 306263000695 nucleotide binding site [chemical binding]; other site 306263000696 HIGH motif; other site 306263000697 KMSKS motif; other site 306263000698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263000699 active site 306263000700 phosphorylation site [posttranslational modification] 306263000701 intermolecular recognition site; other site 306263000702 dimerization interface [polypeptide binding]; other site 306263000703 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 306263000704 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 306263000705 substrate binding site; other site 306263000706 dimer interface; other site 306263000707 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 306263000708 homotrimer interaction site [polypeptide binding]; other site 306263000709 zinc binding site [ion binding]; other site 306263000710 CDP-binding sites; other site 306263000711 antiporter inner membrane protein; Provisional; Region: PRK11670 306263000712 Domain of unknown function DUF59; Region: DUF59; cl00941 306263000713 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 306263000714 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 306263000715 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 306263000716 putative trimer interface [polypeptide binding]; other site 306263000717 putative CoA binding site [chemical binding]; other site 306263000718 Ferritin-like domain; Region: Ferritin; pfam00210 306263000719 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 306263000720 dimerization interface [polypeptide binding]; other site 306263000721 DPS ferroxidase diiron center [ion binding]; other site 306263000722 ion pore; other site 306263000723 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 306263000724 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 306263000725 active site 306263000726 dimer interface [polypeptide binding]; other site 306263000727 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 306263000728 dimer interface [polypeptide binding]; other site 306263000729 active site 306263000730 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 306263000731 active site 306263000732 tetramer interface; other site 306263000733 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 306263000734 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 306263000735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263000736 Walker A/P-loop; other site 306263000737 ATP binding site [chemical binding]; other site 306263000738 Q-loop/lid; other site 306263000739 ABC transporter signature motif; other site 306263000740 Walker B; other site 306263000741 D-loop; other site 306263000742 H-loop/switch region; other site 306263000743 ABC transporter; Region: ABC_tran_2; pfam12848 306263000744 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 306263000745 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 306263000746 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 306263000747 active site 306263000748 substrate binding site [chemical binding]; other site 306263000749 metal binding site [ion binding]; metal-binding site 306263000750 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 306263000751 Ligand Binding Site [chemical binding]; other site 306263000752 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 306263000753 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 306263000754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000755 FeS/SAM binding site; other site 306263000756 peptide chain release factor 2; Validated; Region: prfB; PRK00578 306263000757 RF-1 domain; Region: RF-1; cl02875 306263000758 RF-1 domain; Region: RF-1; cl02875 306263000759 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306263000760 Ligand Binding Site [chemical binding]; other site 306263000761 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306263000762 Ligand Binding Site [chemical binding]; other site 306263000763 Ion channel; Region: Ion_trans_2; cl11596 306263000764 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 306263000765 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 306263000766 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 306263000767 Helix-turn-helix domains; Region: HTH; cl00088 306263000768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 306263000769 dimerization interface [polypeptide binding]; other site 306263000770 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 306263000771 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263000772 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 306263000773 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 306263000774 Mg++ binding site [ion binding]; other site 306263000775 putative catalytic motif [active] 306263000776 putative substrate binding site [chemical binding]; other site 306263000777 Sulfatase; Region: Sulfatase; cl10460 306263000778 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 306263000779 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 306263000780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263000781 NAD(P) binding site [chemical binding]; other site 306263000782 active site 306263000783 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 306263000784 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 306263000785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 306263000786 YheO-like PAS domain; Region: PAS_6; pfam08348 306263000787 Helix-turn-helix domains; Region: HTH; cl00088 306263000788 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 306263000789 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 306263000790 tetramer interface [polypeptide binding]; other site 306263000791 heme binding pocket [chemical binding]; other site 306263000792 NADPH binding site [chemical binding]; other site 306263000793 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 306263000794 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 306263000795 argininosuccinate lyase; Provisional; Region: PRK00855 306263000796 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 306263000797 active sites [active] 306263000798 tetramer interface [polypeptide binding]; other site 306263000799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 306263000800 YheO-like PAS domain; Region: PAS_6; pfam08348 306263000801 Helix-turn-helix domains; Region: HTH; cl00088 306263000802 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 306263000803 homotrimer interaction site [polypeptide binding]; other site 306263000804 putative active site [active] 306263000805 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 306263000806 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 306263000807 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263000808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263000809 catalytic residue [active] 306263000810 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 306263000811 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 306263000812 tetramer interface [polypeptide binding]; other site 306263000813 active site 306263000814 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 306263000815 FeoA domain; Region: FeoA; cl00838 306263000816 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 306263000817 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 306263000818 G1 box; other site 306263000819 GTP/Mg2+ binding site [chemical binding]; other site 306263000820 Switch I region; other site 306263000821 G2 box; other site 306263000822 G3 box; other site 306263000823 Switch II region; other site 306263000824 G4 box; other site 306263000825 G5 box; other site 306263000826 Nucleoside recognition; Region: Gate; cl00486 306263000827 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 306263000828 Nucleoside recognition; Region: Gate; cl00486 306263000829 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 306263000830 Phosphopantetheine attachment site; Region: PP-binding; cl09936 306263000831 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 306263000832 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 306263000833 dimer interface [polypeptide binding]; other site 306263000834 active site 306263000835 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 306263000836 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 306263000837 Cla_0288; potential protein location (conserved hypothetical protein (DUF455 domain protein) [Campylobacter lari RM2100]) that overlaps RNA (tRNA-F) 306263000838 ABC-2 type transporter; Region: ABC2_membrane; cl11417 306263000839 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 306263000840 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 306263000841 Walker A/P-loop; other site 306263000842 ATP binding site [chemical binding]; other site 306263000843 Q-loop/lid; other site 306263000844 ABC transporter signature motif; other site 306263000845 Walker B; other site 306263000846 D-loop; other site 306263000847 H-loop/switch region; other site 306263000848 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 306263000849 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 306263000850 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 306263000851 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 306263000852 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 306263000853 putative active site [active] 306263000854 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 306263000855 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263000856 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 306263000857 active site 306263000858 nucleotide binding site [chemical binding]; other site 306263000859 HIGH motif; other site 306263000860 KMSKS motif; other site 306263000861 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 306263000862 LicD family; Region: LicD; cl01378 306263000863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263000864 binding surface 306263000865 TPR motif; other site 306263000866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263000867 binding surface 306263000868 TPR motif; other site 306263000869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263000870 binding surface 306263000871 TPR motif; other site 306263000872 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 306263000873 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 306263000874 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 306263000875 putative ADP-binding pocket [chemical binding]; other site 306263000876 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 306263000877 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263000878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306263000879 active site 306263000880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306263000881 active site 306263000882 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 306263000883 active site 306263000884 catalytic site [active] 306263000885 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 306263000886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263000887 motif II; other site 306263000888 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 306263000889 Ligand binding site; other site 306263000890 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 306263000891 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 306263000892 Ligand binding site; other site 306263000893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263000894 S-adenosylmethionine binding site [chemical binding]; other site 306263000895 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 306263000896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263000897 S-adenosylmethionine binding site [chemical binding]; other site 306263000898 hypothetical protein; Provisional; Region: PRK05849 306263000899 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 306263000900 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 306263000901 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 306263000902 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 306263000903 catalytic triad [active] 306263000904 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 306263000905 active site 306263000906 metal-binding site 306263000907 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 306263000908 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 306263000909 ligand-binding site [chemical binding]; other site 306263000910 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 306263000911 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 306263000912 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 306263000913 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 306263000914 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 306263000915 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 306263000916 NusA N-terminal domain; Region: NusA_N; pfam08529 306263000917 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 306263000918 RNA binding site [nucleotide binding]; other site 306263000919 homodimer interface [polypeptide binding]; other site 306263000920 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 306263000921 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 306263000922 G-X-X-G motif; other site 306263000923 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 306263000924 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 306263000925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000926 FeS/SAM binding site; other site 306263000927 TRAM domain; Region: TRAM; cl01282 306263000928 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 306263000929 putative acyl-acceptor binding pocket; other site 306263000930 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 306263000931 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 306263000932 Iron-sulfur protein interface; other site 306263000933 proximal heme binding site [chemical binding]; other site 306263000934 distal heme binding site [chemical binding]; other site 306263000935 dimer interface [polypeptide binding]; other site 306263000936 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 306263000937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263000938 domain; Region: Succ_DH_flav_C; pfam02910 306263000939 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 306263000940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 306263000941 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 306263000942 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 306263000943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263000944 Dynamin family; Region: Dynamin_N; pfam00350 306263000945 G1 box; other site 306263000946 GTP/Mg2+ binding site [chemical binding]; other site 306263000947 G2 box; other site 306263000948 Switch I region; other site 306263000949 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 306263000950 G3 box; other site 306263000951 Switch II region; other site 306263000952 GTP/Mg2+ binding site [chemical binding]; other site 306263000953 G4 box; other site 306263000954 G5 box; other site 306263000955 DNA polymerase III PolC; Validated; Region: polC; PRK00448 306263000956 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 306263000957 G1 box; other site 306263000958 GTP/Mg2+ binding site [chemical binding]; other site 306263000959 G2 box; other site 306263000960 Switch I region; other site 306263000961 G3 box; other site 306263000962 Switch II region; other site 306263000963 G4 box; other site 306263000964 G5 box; other site 306263000965 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 306263000966 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 306263000967 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 306263000968 Helix-turn-helix domains; Region: HTH; cl00088 306263000969 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 306263000970 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 306263000971 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 306263000972 putative NAD(P) binding site [chemical binding]; other site 306263000973 putative substrate binding site [chemical binding]; other site 306263000974 catalytic Zn binding site [ion binding]; other site 306263000975 structural Zn binding site [ion binding]; other site 306263000976 dimer interface [polypeptide binding]; other site 306263000977 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 306263000978 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 306263000979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263000980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263000981 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 306263000982 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 306263000983 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 306263000984 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 306263000985 Virulence protein [General function prediction only]; Region: COG3943 306263000986 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 306263000987 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 306263000988 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 306263000989 dimer interface [polypeptide binding]; other site 306263000990 putative functional site; other site 306263000991 putative MPT binding site; other site 306263000992 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 306263000993 MoaE homodimer interface [polypeptide binding]; other site 306263000994 MoaD interaction [polypeptide binding]; other site 306263000995 active site residues [active] 306263000996 Ubiquitin-like proteins; Region: UBQ; cl00155 306263000997 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 306263000998 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 306263000999 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 306263001000 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 306263001001 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 306263001002 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 306263001003 dimer interface [polypeptide binding]; other site 306263001004 active site 306263001005 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263001006 catalytic residues [active] 306263001007 substrate binding site [chemical binding]; other site 306263001008 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 306263001009 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 306263001010 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 306263001011 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 306263001012 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 306263001013 [4Fe-4S] binding site [ion binding]; other site 306263001014 molybdopterin cofactor binding site; other site 306263001015 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263001016 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 306263001017 molybdopterin cofactor binding site; other site 306263001018 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 306263001019 Helix-turn-helix domains; Region: HTH; cl00088 306263001020 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 306263001021 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 306263001022 CPxP motif; other site 306263001023 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 306263001024 dimerization interface [polypeptide binding]; other site 306263001025 putative ATP binding site [chemical binding]; other site 306263001026 Proline dehydrogenase; Region: Pro_dh; cl03282 306263001027 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 306263001028 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 306263001029 NAD(P) binding site [chemical binding]; other site 306263001030 catalytic residues [active] 306263001031 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 306263001032 Sodium:solute symporter family; Region: SSF; cl00456 306263001033 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 306263001034 CPxP motif; other site 306263001035 putative inner membrane protein; Provisional; Region: PRK11099 306263001036 Sulphur transport; Region: Sulf_transp; cl01018 306263001037 Sulphur transport; Region: Sulf_transp; cl01018 306263001038 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 306263001039 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 306263001040 GDP-binding site [chemical binding]; other site 306263001041 ACT binding site; other site 306263001042 IMP binding site; other site 306263001043 Flagellar FliJ protein; Region: FliJ; pfam02050 306263001044 MgtE intracellular N domain; Region: MgtE_N; cl15244 306263001045 Protein of unknown function (DUF507); Region: DUF507; cl01112 306263001046 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 306263001047 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 306263001048 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 306263001049 catalytic site [active] 306263001050 subunit interface [polypeptide binding]; other site 306263001051 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 306263001052 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 306263001053 Low-spin heme binding site [chemical binding]; other site 306263001054 D-pathway; other site 306263001055 Putative water exit pathway; other site 306263001056 Binuclear center (active site) [active] 306263001057 K-pathway; other site 306263001058 Putative proton exit pathway; other site 306263001059 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 306263001060 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 306263001061 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 306263001062 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 306263001063 Cytochrome c; Region: Cytochrom_C; cl11414 306263001064 Cytochrome c; Region: Cytochrom_C; cl11414 306263001065 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 306263001066 FixH; Region: FixH; cl01254 306263001067 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 306263001068 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 306263001069 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 306263001070 putative recombination protein RecB; Provisional; Region: PRK13909 306263001071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001073 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 306263001074 Cache domain; Region: Cache_1; pfam02743 306263001075 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263001076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263001077 dimer interface [polypeptide binding]; other site 306263001078 putative CheW interface [polypeptide binding]; other site 306263001079 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 306263001080 23S rRNA interface [nucleotide binding]; other site 306263001081 L3 interface [polypeptide binding]; other site 306263001082 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 306263001083 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 306263001084 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 306263001085 ligand binding site [chemical binding]; other site 306263001086 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 306263001087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263001088 active site 306263001089 motif I; other site 306263001090 motif II; other site 306263001091 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 306263001092 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 306263001093 dimer interface [polypeptide binding]; other site 306263001094 PYR/PP interface [polypeptide binding]; other site 306263001095 TPP binding site [chemical binding]; other site 306263001096 substrate binding site [chemical binding]; other site 306263001097 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 306263001098 Domain of unknown function; Region: EKR; cl11037 306263001099 4Fe-4S binding domain; Region: Fer4; cl02805 306263001100 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 306263001101 TPP-binding site [chemical binding]; other site 306263001102 dimer interface [polypeptide binding]; other site 306263001103 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 306263001104 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 306263001105 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 306263001106 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 306263001107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001108 Walker A motif; other site 306263001109 ATP binding site [chemical binding]; other site 306263001110 Walker B motif; other site 306263001111 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 306263001112 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 306263001113 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 306263001114 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 306263001115 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 306263001116 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 306263001117 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 306263001118 FlgN protein; Region: FlgN; cl09176 306263001119 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 306263001120 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 306263001121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001122 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 306263001123 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 306263001124 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 306263001125 thiamine monophosphate kinase; Provisional; Region: PRK05731 306263001126 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 306263001127 ATP binding site [chemical binding]; other site 306263001128 dimerization interface [polypeptide binding]; other site 306263001129 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 306263001130 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 306263001131 Permutation of conserved domain; other site 306263001132 active site 306263001133 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 306263001134 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 306263001135 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 306263001136 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 306263001137 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 306263001138 dUTPase; Region: dUTPase_2; pfam08761 306263001139 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 306263001140 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 306263001141 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 306263001142 substrate binding site [chemical binding]; other site 306263001143 dimer interface [polypeptide binding]; other site 306263001144 catalytic triad [active] 306263001145 Phosphoglycerate kinase; Region: PGK; pfam00162 306263001146 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 306263001147 substrate binding site [chemical binding]; other site 306263001148 hinge regions; other site 306263001149 ADP binding site [chemical binding]; other site 306263001150 catalytic site [active] 306263001151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001152 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 306263001153 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 306263001154 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 306263001155 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 306263001156 active site 306263001157 (T/H)XGH motif; other site 306263001158 Oligomerisation domain; Region: Oligomerisation; cl00519 306263001159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001160 binding surface 306263001161 TPR motif; other site 306263001162 TPR repeat; Region: TPR_11; pfam13414 306263001163 TPR repeat; Region: TPR_11; pfam13414 306263001164 TPR repeat; Region: TPR_11; pfam13414 306263001165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001166 binding surface 306263001167 TPR motif; other site 306263001168 TPR repeat; Region: TPR_11; pfam13414 306263001169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001170 binding surface 306263001171 TPR motif; other site 306263001172 Tetratricopeptide repeat; Region: TPR_16; pfam13432 306263001173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001174 binding surface 306263001175 TPR motif; other site 306263001176 Tetratricopeptide repeat; Region: TPR_12; pfam13424 306263001177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001178 binding surface 306263001179 TPR repeat; Region: TPR_11; pfam13414 306263001180 TPR motif; other site 306263001181 TPR repeat; Region: TPR_11; pfam13414 306263001182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001183 binding surface 306263001184 TPR repeat; Region: TPR_11; pfam13414 306263001185 TPR motif; other site 306263001186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 306263001187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 306263001188 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 306263001189 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 306263001190 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 306263001191 fumarate hydratase; Reviewed; Region: fumC; PRK00485 306263001192 Class II fumarases; Region: Fumarase_classII; cd01362 306263001193 active site 306263001194 tetramer interface [polypeptide binding]; other site 306263001195 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 306263001196 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 306263001197 glutaminase active site [active] 306263001198 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 306263001199 dimer interface [polypeptide binding]; other site 306263001200 active site 306263001201 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 306263001202 dimer interface [polypeptide binding]; other site 306263001203 active site 306263001204 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 306263001205 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 306263001206 hypothetical protein; Provisional; Region: PRK08444 306263001207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 306263001208 FeS/SAM binding site; other site 306263001209 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 306263001210 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 306263001211 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 306263001212 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 306263001213 molybdopterin cofactor binding site [chemical binding]; other site 306263001214 substrate binding site [chemical binding]; other site 306263001215 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 306263001216 molybdopterin cofactor binding site; other site 306263001217 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 306263001218 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 306263001219 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 306263001220 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 306263001221 Protein of unknown function (DUF328); Region: DUF328; cl01143 306263001222 elongation factor Tu; Reviewed; Region: PRK00049 306263001223 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 306263001224 G1 box; other site 306263001225 GEF interaction site [polypeptide binding]; other site 306263001226 GTP/Mg2+ binding site [chemical binding]; other site 306263001227 Switch I region; other site 306263001228 G2 box; other site 306263001229 G3 box; other site 306263001230 Switch II region; other site 306263001231 G4 box; other site 306263001232 G5 box; other site 306263001233 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 306263001234 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 306263001235 Antibiotic Binding Site [chemical binding]; other site 306263001236 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 306263001237 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 306263001238 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 306263001239 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 306263001240 putative homodimer interface [polypeptide binding]; other site 306263001241 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 306263001242 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 306263001243 23S rRNA interface [nucleotide binding]; other site 306263001244 L7/L12 interface [polypeptide binding]; other site 306263001245 putative thiostrepton binding site; other site 306263001246 L25 interface [polypeptide binding]; other site 306263001247 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 306263001248 mRNA/rRNA interface [nucleotide binding]; other site 306263001249 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 306263001250 23S rRNA interface [nucleotide binding]; other site 306263001251 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 306263001252 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 306263001253 L11 interface [polypeptide binding]; other site 306263001254 putative EF-Tu interaction site [polypeptide binding]; other site 306263001255 putative EF-G interaction site [polypeptide binding]; other site 306263001256 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 306263001257 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 306263001258 RPB12 interaction site [polypeptide binding]; other site 306263001259 RPB11 interaction site [polypeptide binding]; other site 306263001260 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 306263001261 RPB3 interaction site [polypeptide binding]; other site 306263001262 RPB1 interaction site [polypeptide binding]; other site 306263001263 RPB11 interaction site [polypeptide binding]; other site 306263001264 RPB10 interaction site [polypeptide binding]; other site 306263001265 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 306263001266 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 306263001267 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 306263001268 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 306263001269 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 306263001270 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 306263001271 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 306263001272 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 306263001273 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Provisional; Region: PRK14844 306263001274 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 306263001275 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 306263001276 DNA binding site [nucleotide binding] 306263001277 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 306263001278 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 306263001279 S17 interaction site [polypeptide binding]; other site 306263001280 S8 interaction site; other site 306263001281 16S rRNA interaction site [nucleotide binding]; other site 306263001282 streptomycin interaction site [chemical binding]; other site 306263001283 23S rRNA interaction site [nucleotide binding]; other site 306263001284 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 306263001285 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 306263001286 elongation factor G; Reviewed; Region: PRK00007 306263001287 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 306263001288 G1 box; other site 306263001289 putative GEF interaction site [polypeptide binding]; other site 306263001290 GTP/Mg2+ binding site [chemical binding]; other site 306263001291 Switch I region; other site 306263001292 G2 box; other site 306263001293 G3 box; other site 306263001294 Switch II region; other site 306263001295 G4 box; other site 306263001296 G5 box; other site 306263001297 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 306263001298 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 306263001299 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 306263001300 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 306263001301 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 306263001302 Domain of unknown function DUF21; Region: DUF21; pfam01595 306263001303 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 306263001304 Transporter associated domain; Region: CorC_HlyC; cl08393 306263001305 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 306263001306 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 306263001307 Sodium:solute symporter family; Region: SSF; cl00456 306263001308 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 306263001309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001310 NAD(P) binding pocket [chemical binding]; other site 306263001311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263001312 dimer interface [polypeptide binding]; other site 306263001313 conserved gate region; other site 306263001314 putative PBP binding loops; other site 306263001315 ABC-ATPase subunit interface; other site 306263001316 Protein of unknown function, DUF; Region: DUF411; cl01142 306263001317 Gram-negative bacterial tonB protein; Region: TonB; cl10048 306263001318 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 306263001319 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 306263001320 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 306263001321 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 306263001322 N-terminal plug; other site 306263001323 ligand-binding site [chemical binding]; other site 306263001324 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 306263001325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263001326 Walker A motif; other site 306263001327 ATP binding site [chemical binding]; other site 306263001328 Walker B motif; other site 306263001329 transcription termination factor Rho; Provisional; Region: rho; PRK09376 306263001330 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 306263001331 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 306263001332 RNA binding site [nucleotide binding]; other site 306263001333 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 306263001334 multimer interface [polypeptide binding]; other site 306263001335 Walker A motif; other site 306263001336 ATP binding site [chemical binding]; other site 306263001337 Walker B motif; other site 306263001338 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 306263001339 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 306263001340 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 306263001341 metal-binding site [ion binding] 306263001342 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306263001343 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263001344 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 306263001345 Cytochrome c; Region: Cytochrom_C; cl11414 306263001346 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 306263001347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263001348 active site 306263001349 motif I; other site 306263001350 motif II; other site 306263001351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001352 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 306263001353 NAD(P) binding site [chemical binding]; other site 306263001354 active site 306263001355 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 306263001356 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 306263001357 putative ribose interaction site [chemical binding]; other site 306263001358 putative ADP binding site [chemical binding]; other site 306263001359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263001360 active site 306263001361 nucleotide binding site [chemical binding]; other site 306263001362 HIGH motif; other site 306263001363 KMSKS motif; other site 306263001364 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 306263001365 dimer interface [polypeptide binding]; other site 306263001366 active site 306263001367 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 306263001368 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 306263001369 domain interfaces; other site 306263001370 active site 306263001371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001372 Predicted dehydrogenase [General function prediction only]; Region: COG0579 306263001373 Type III pantothenate kinase; Region: Pan_kinase; cl09130 306263001374 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 306263001375 Colicin V production protein; Region: Colicin_V; cl00567 306263001376 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 306263001377 metal binding site 2 [ion binding]; metal-binding site 306263001378 putative DNA binding helix; other site 306263001379 metal binding site 1 [ion binding]; metal-binding site 306263001380 dimer interface [polypeptide binding]; other site 306263001381 structural Zn2+ binding site [ion binding]; other site 306263001382 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 306263001383 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 306263001384 dimer interface [polypeptide binding]; other site 306263001385 putative anticodon binding site; other site 306263001386 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 306263001387 motif 1; other site 306263001388 active site 306263001389 motif 2; other site 306263001390 motif 3; other site 306263001391 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 306263001392 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 306263001393 dimer interface [polypeptide binding]; other site 306263001394 glycine-pyridoxal phosphate binding site [chemical binding]; other site 306263001395 active site 306263001396 folate binding site [chemical binding]; other site 306263001397 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 306263001398 Sporulation related domain; Region: SPOR; cl10051 306263001399 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 306263001400 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 306263001401 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 306263001402 shikimate binding site; other site 306263001403 NAD(P) binding site [chemical binding]; other site 306263001404 chaperone protein DnaJ; Provisional; Region: PRK10767 306263001405 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306263001406 HSP70 interaction site [polypeptide binding]; other site 306263001407 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 306263001408 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 306263001409 Zn binding sites [ion binding]; other site 306263001410 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 306263001411 dimer interface [polypeptide binding]; other site 306263001412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263001413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263001414 active site 306263001415 phosphorylation site [posttranslational modification] 306263001416 intermolecular recognition site; other site 306263001417 dimerization interface [polypeptide binding]; other site 306263001418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306263001419 DNA binding site [nucleotide binding] 306263001420 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 306263001421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 306263001422 dimer interface [polypeptide binding]; other site 306263001423 phosphorylation site [posttranslational modification] 306263001424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263001425 ATP binding site [chemical binding]; other site 306263001426 Mg2+ binding site [ion binding]; other site 306263001427 G-X-G motif; other site 306263001428 recombination protein RecR; Reviewed; Region: recR; PRK00076 306263001429 RecR protein; Region: RecR; pfam02132 306263001430 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 306263001431 putative active site [active] 306263001432 putative metal-binding site [ion binding]; other site 306263001433 tetramer interface [polypeptide binding]; other site 306263001434 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 306263001435 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 306263001436 GIY-YIG motif/motif A; other site 306263001437 active site 306263001438 catalytic site [active] 306263001439 putative DNA binding site [nucleotide binding]; other site 306263001440 metal binding site [ion binding]; metal-binding site 306263001441 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 306263001442 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 306263001443 transmembrane helices; other site 306263001444 Citrate transporter; Region: CitMHS; pfam03600 306263001445 GMP synthase; Reviewed; Region: guaA; PRK00074 306263001446 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 306263001447 AMP/PPi binding site [chemical binding]; other site 306263001448 candidate oxyanion hole; other site 306263001449 catalytic triad [active] 306263001450 potential glutamine specificity residues [chemical binding]; other site 306263001451 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 306263001452 ATP Binding subdomain [chemical binding]; other site 306263001453 Ligand Binding sites [chemical binding]; other site 306263001454 Dimerization subdomain; other site 306263001455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263001456 S-adenosylmethionine binding site [chemical binding]; other site 306263001457 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 306263001458 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 306263001459 ATP-grasp domain; Region: ATP-grasp_4; cl03087 306263001460 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 306263001461 RDD family; Region: RDD; cl00746 306263001462 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 306263001463 Organic solvent tolerance protein; Region: OstA_C; pfam04453 306263001464 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 306263001465 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 306263001466 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 306263001467 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 306263001468 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 306263001469 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 306263001470 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 306263001471 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 306263001472 putative nucleic acid binding region [nucleotide binding]; other site 306263001473 G-X-X-G motif; other site 306263001474 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306263001475 RNA binding site [nucleotide binding]; other site 306263001476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001477 PIF1-like helicase; Region: PIF1; pfam05970 306263001478 Helicase; Region: Herpes_Helicase; pfam02689 306263001479 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 306263001480 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 306263001481 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 306263001482 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001483 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 306263001484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306263001485 nucleotide binding region [chemical binding]; other site 306263001486 ATP-binding site [chemical binding]; other site 306263001487 SEC-C motif; Region: SEC-C; pfam02810 306263001488 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 306263001489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263001490 active site 306263001491 phosphorylation site [posttranslational modification] 306263001492 intermolecular recognition site; other site 306263001493 dimerization interface [polypeptide binding]; other site 306263001494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263001495 Walker A motif; other site 306263001496 ATP binding site [chemical binding]; other site 306263001497 Walker B motif; other site 306263001498 arginine finger; other site 306263001499 Helix-turn-helix domains; Region: HTH; cl00088 306263001500 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 306263001501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001502 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 306263001503 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 306263001504 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 306263001505 substrate binding site [chemical binding]; other site 306263001506 active site 306263001507 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 306263001508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263001509 FeS/SAM binding site; other site 306263001510 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 306263001511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 306263001512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 306263001513 binding surface 306263001514 TPR motif; other site 306263001515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 306263001516 seryl-tRNA synthetase; Provisional; Region: PRK05431 306263001517 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 306263001518 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 306263001519 dimer interface [polypeptide binding]; other site 306263001520 active site 306263001521 motif 1; other site 306263001522 motif 2; other site 306263001523 motif 3; other site 306263001524 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 306263001525 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 306263001526 active site 306263001527 HIGH motif; other site 306263001528 dimer interface [polypeptide binding]; other site 306263001529 KMSKS motif; other site 306263001530 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 306263001531 ADP binding site [chemical binding]; other site 306263001532 magnesium binding site [ion binding]; other site 306263001533 putative shikimate binding site; other site 306263001534 GTP-binding protein Der; Reviewed; Region: PRK00093 306263001535 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 306263001536 G1 box; other site 306263001537 GTP/Mg2+ binding site [chemical binding]; other site 306263001538 Switch I region; other site 306263001539 G2 box; other site 306263001540 Switch II region; other site 306263001541 G3 box; other site 306263001542 G4 box; other site 306263001543 G5 box; other site 306263001544 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 306263001545 G1 box; other site 306263001546 GTP/Mg2+ binding site [chemical binding]; other site 306263001547 Switch I region; other site 306263001548 G2 box; other site 306263001549 G3 box; other site 306263001550 Switch II region; other site 306263001551 G4 box; other site 306263001552 G5 box; other site 306263001553 EamA-like transporter family; Region: EamA; cl01037 306263001554 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 306263001555 xanthine permease; Region: pbuX; TIGR03173 306263001556 NeuB family; Region: NeuB; cl00496 306263001557 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 306263001558 homopentamer interface [polypeptide binding]; other site 306263001559 active site 306263001560 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 306263001561 putative RNA binding site [nucleotide binding]; other site 306263001562 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 306263001563 active site 306263001564 dimer interface [polypeptide binding]; other site 306263001565 META domain; Region: META; cl01245 306263001566 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 306263001567 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 306263001568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263001569 dimer interface [polypeptide binding]; other site 306263001570 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 306263001571 putative CheW interface [polypeptide binding]; other site 306263001572 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 306263001573 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 306263001574 purine monophosphate binding site [chemical binding]; other site 306263001575 dimer interface [polypeptide binding]; other site 306263001576 putative catalytic residues [active] 306263001577 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 306263001578 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 306263001579 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 306263001580 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 306263001581 putative metal binding site [ion binding]; other site 306263001582 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306263001583 HSP70 interaction site [polypeptide binding]; other site 306263001584 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 306263001585 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 306263001586 dimerization interface [polypeptide binding]; other site 306263001587 ATP binding site [chemical binding]; other site 306263001588 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 306263001589 dimerization interface [polypeptide binding]; other site 306263001590 ATP binding site [chemical binding]; other site 306263001591 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 306263001592 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 306263001593 trmE is a tRNA modification GTPase; Region: trmE; cd04164 306263001594 G1 box; other site 306263001595 GTP/Mg2+ binding site [chemical binding]; other site 306263001596 Switch I region; other site 306263001597 G2 box; other site 306263001598 Switch II region; other site 306263001599 G3 box; other site 306263001600 G4 box; other site 306263001601 G5 box; other site 306263001602 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 306263001603 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 306263001604 membrane protein insertase; Provisional; Region: PRK01318 306263001605 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 306263001606 Haemolytic domain; Region: Haemolytic; cl00506 306263001607 Ribonuclease P; Region: Ribonuclease_P; cl00457 306263001608 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 306263001609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 306263001610 Coenzyme A binding pocket [chemical binding]; other site 306263001611 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_2; cd10034 306263001612 putative uracil binding site [chemical binding]; other site 306263001613 putative active site [active] 306263001614 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 306263001615 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 306263001616 active site 306263001617 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 306263001618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001619 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 306263001620 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 306263001621 catalytic residues [active] 306263001622 hinge region; other site 306263001623 alpha helical domain; other site 306263001624 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 306263001625 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 306263001626 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 306263001627 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 306263001628 metal binding site [ion binding]; metal-binding site 306263001629 Staphylococcal nuclease homologues; Region: SNc; smart00318 306263001630 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 306263001631 Catalytic site; other site 306263001632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 306263001633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263001634 S-adenosylmethionine binding site [chemical binding]; other site 306263001635 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 306263001636 flagellin; Provisional; Region: PRK12804 306263001637 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 306263001638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263001639 S-adenosylmethionine binding site [chemical binding]; other site 306263001640 Peptidase family M48; Region: Peptidase_M48; cl12018 306263001641 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 306263001642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001643 Walker A/P-loop; other site 306263001644 ATP binding site [chemical binding]; other site 306263001645 Q-loop/lid; other site 306263001646 ABC transporter signature motif; other site 306263001647 Walker B; other site 306263001648 D-loop; other site 306263001649 H-loop/switch region; other site 306263001650 ABC transporter; Region: ABC_tran_2; pfam12848 306263001651 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 306263001652 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 306263001653 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 306263001654 putative active site [active] 306263001655 putative metal binding site [ion binding]; other site 306263001656 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 306263001657 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 306263001658 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 306263001659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263001660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306263001661 putative substrate translocation pore; other site 306263001662 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 306263001663 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 306263001664 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 306263001665 inhibitor-cofactor binding pocket; inhibition site 306263001666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263001667 catalytic residue [active] 306263001668 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14166 306263001669 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 306263001670 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 306263001671 homodimer interface [polypeptide binding]; other site 306263001672 NADP binding site [chemical binding]; other site 306263001673 substrate binding site [chemical binding]; other site 306263001674 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 306263001675 signal peptidase I; Provisional; Region: PRK10861 306263001676 Catalytic site [active] 306263001677 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 306263001678 aspartate aminotransferase; Provisional; Region: PRK05764 306263001679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306263001680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263001681 homodimer interface [polypeptide binding]; other site 306263001682 catalytic residue [active] 306263001683 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 306263001684 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 306263001685 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 306263001686 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 306263001687 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 306263001688 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306263001689 ATP-grasp domain; Region: ATP-grasp_4; cl03087 306263001690 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 306263001691 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 306263001692 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 306263001693 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 306263001694 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306263001695 HSP70 interaction site [polypeptide binding]; other site 306263001696 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 306263001697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306263001698 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 306263001699 substrate binding pocket [chemical binding]; other site 306263001700 membrane-bound complex binding site; other site 306263001701 hinge residues; other site 306263001702 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 306263001703 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263001704 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263001705 catalytic residue [active] 306263001706 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 306263001707 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 306263001708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306263001709 dimer interface [polypeptide binding]; other site 306263001710 phosphorylation site [posttranslational modification] 306263001711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 306263001712 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 306263001713 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 306263001714 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 306263001715 Walker A/P-loop; other site 306263001716 ATP binding site [chemical binding]; other site 306263001717 Q-loop/lid; other site 306263001718 ABC transporter signature motif; other site 306263001719 Walker B; other site 306263001720 D-loop; other site 306263001721 H-loop/switch region; other site 306263001722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263001723 dimer interface [polypeptide binding]; other site 306263001724 conserved gate region; other site 306263001725 putative PBP binding loops; other site 306263001726 ABC-ATPase subunit interface; other site 306263001727 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 306263001728 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 306263001729 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 306263001730 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306263001731 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263001732 Uncharacterized conserved protein [Function unknown]; Region: COG1565 306263001733 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 306263001734 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 306263001735 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 306263001736 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 306263001737 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 306263001738 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306263001739 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 306263001740 active site 306263001741 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 306263001742 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 306263001743 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 306263001744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 306263001745 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306263001746 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 306263001747 Walker A/P-loop; other site 306263001748 ATP binding site [chemical binding]; other site 306263001749 Q-loop/lid; other site 306263001750 ABC transporter signature motif; other site 306263001751 Walker B; other site 306263001752 D-loop; other site 306263001753 H-loop/switch region; other site 306263001754 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 306263001755 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263001756 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 306263001757 putative nucleotide binding site [chemical binding]; other site 306263001758 uridine monophosphate binding site [chemical binding]; other site 306263001759 homohexameric interface [polypeptide binding]; other site 306263001760 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 306263001761 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 306263001762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 306263001763 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 306263001764 synthetase active site [active] 306263001765 NTP binding site [chemical binding]; other site 306263001766 metal binding site [ion binding]; metal-binding site 306263001767 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 306263001768 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 306263001769 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 306263001770 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 306263001771 active site 306263001772 HIGH motif; other site 306263001773 dimer interface [polypeptide binding]; other site 306263001774 KMSKS motif; other site 306263001775 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306263001776 RNA binding surface [nucleotide binding]; other site 306263001777 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 306263001778 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 306263001779 FMN binding site [chemical binding]; other site 306263001780 substrate binding site [chemical binding]; other site 306263001781 putative catalytic residue [active] 306263001782 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 306263001783 active site 306263001784 metal binding site [ion binding]; metal-binding site 306263001785 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 306263001786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 306263001787 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 306263001788 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 306263001789 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 306263001790 active site 306263001791 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 306263001792 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 306263001793 putative substrate binding region [chemical binding]; other site 306263001794 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 306263001795 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 306263001796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001797 NAD(P) binding site [chemical binding]; other site 306263001798 active site 306263001799 dihydrodipicolinate synthase; Region: dapA; TIGR00674 306263001800 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 306263001801 dimer interface [polypeptide binding]; other site 306263001802 active site 306263001803 catalytic residue [active] 306263001804 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 306263001805 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 306263001806 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 306263001807 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 306263001808 quinone interaction residues [chemical binding]; other site 306263001809 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 306263001810 active site 306263001811 catalytic residues [active] 306263001812 FMN binding site [chemical binding]; other site 306263001813 substrate binding site [chemical binding]; other site 306263001814 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 306263001815 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 306263001816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001817 Walker A/P-loop; other site 306263001818 ATP binding site [chemical binding]; other site 306263001819 Q-loop/lid; other site 306263001820 ABC transporter signature motif; other site 306263001821 Walker B; other site 306263001822 D-loop; other site 306263001823 H-loop/switch region; other site 306263001824 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 306263001825 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 306263001826 active site 306263001827 HIGH motif; other site 306263001828 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 306263001829 KMSKS motif; other site 306263001830 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306263001831 tRNA binding surface [nucleotide binding]; other site 306263001832 anticodon binding site; other site 306263001833 integral membrane protein MviN; Region: mviN; TIGR01695 306263001834 Protein of unknown function (DUF342); Region: DUF342; pfam03961 306263001835 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14601 306263001836 RuvA N terminal domain; Region: RuvA_N; pfam01330 306263001837 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 306263001838 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 306263001839 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 306263001840 ATP-grasp domain; Region: ATP-grasp_4; cl03087 306263001841 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 306263001842 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 306263001843 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 306263001844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263001845 Flagellar L-ring protein; Region: FlgH; cl00905 306263001846 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 306263001847 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 306263001848 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 306263001849 Acetokinase family; Region: Acetate_kinase; cl01029 306263001850 propionate/acetate kinase; Provisional; Region: PRK12379 306263001851 NMT1-like family; Region: NMT1_2; cl15260 306263001852 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306263001853 active site 306263001854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263001855 dimer interface [polypeptide binding]; other site 306263001856 conserved gate region; other site 306263001857 ABC-ATPase subunit interface; other site 306263001858 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 306263001859 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 306263001860 Walker A/P-loop; other site 306263001861 ATP binding site [chemical binding]; other site 306263001862 Q-loop/lid; other site 306263001863 ABC transporter signature motif; other site 306263001864 Walker B; other site 306263001865 D-loop; other site 306263001866 H-loop/switch region; other site 306263001867 NIL domain; Region: NIL; cl09633 306263001868 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 306263001869 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263001870 active site 306263001871 HIGH motif; other site 306263001872 nucleotide binding site [chemical binding]; other site 306263001873 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 306263001874 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 306263001875 active site 306263001876 KMSKS motif; other site 306263001877 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 306263001878 tRNA binding surface [nucleotide binding]; other site 306263001879 anticodon binding site; other site 306263001880 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 306263001881 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 306263001882 ligand binding site [chemical binding]; other site 306263001883 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 306263001884 dimer interface [polypeptide binding]; other site 306263001885 substrate binding site [chemical binding]; other site 306263001886 metal binding sites [ion binding]; metal-binding site 306263001887 adenylate kinase; Reviewed; Region: adk; PRK00279 306263001888 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 306263001889 AMP-binding site [chemical binding]; other site 306263001890 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 306263001891 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 306263001892 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 306263001893 dimer interface [polypeptide binding]; other site 306263001894 anticodon binding site; other site 306263001895 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 306263001896 homodimer interface [polypeptide binding]; other site 306263001897 motif 1; other site 306263001898 active site 306263001899 motif 2; other site 306263001900 GAD domain; Region: GAD; pfam02938 306263001901 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 306263001902 active site 306263001903 motif 3; other site 306263001904 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 306263001905 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 306263001906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001907 Walker A/P-loop; other site 306263001908 ATP binding site [chemical binding]; other site 306263001909 Q-loop/lid; other site 306263001910 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 306263001911 ABC transporter signature motif; other site 306263001912 Walker B; other site 306263001913 D-loop; other site 306263001914 H-loop/switch region; other site 306263001915 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 306263001916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263001917 active site 306263001918 phosphorylation site [posttranslational modification] 306263001919 intermolecular recognition site; other site 306263001920 dimerization interface [polypeptide binding]; other site 306263001921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263001922 active site 306263001923 phosphorylation site [posttranslational modification] 306263001924 intermolecular recognition site; other site 306263001925 dimerization interface [polypeptide binding]; other site 306263001926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 306263001927 metal binding site [ion binding]; metal-binding site 306263001928 active site 306263001929 I-site; other site 306263001930 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 306263001931 active site 306263001932 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 306263001933 N-acetyl-D-glucosamine binding site [chemical binding]; other site 306263001934 catalytic residue [active] 306263001935 autolysin; Reviewed; Region: PRK06347 306263001936 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 306263001937 putative peptidoglycan binding site; other site 306263001938 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 306263001939 rare lipoprotein A; Region: rlpA; TIGR00413 306263001940 Sporulation related domain; Region: SPOR; cl10051 306263001941 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 306263001942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263001943 active site 306263001944 motif I; other site 306263001945 motif II; other site 306263001946 OstA-like protein; Region: OstA; cl00844 306263001947 Predicted GTPase [General function prediction only]; Region: COG0218 306263001948 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 306263001949 G1 box; other site 306263001950 GTP/Mg2+ binding site [chemical binding]; other site 306263001951 Switch I region; other site 306263001952 G2 box; other site 306263001953 G3 box; other site 306263001954 Switch II region; other site 306263001955 G4 box; other site 306263001956 G5 box; other site 306263001957 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 306263001958 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 306263001959 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 306263001960 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 306263001961 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 306263001962 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 306263001963 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 306263001964 Predicted permease; Region: DUF318; pfam03773 306263001965 Predicted permeases [General function prediction only]; Region: COG0701 306263001966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 306263001967 putative DNA binding site [nucleotide binding]; other site 306263001968 dimerization interface [polypeptide binding]; other site 306263001969 putative Zn2+ binding site [ion binding]; other site 306263001970 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 306263001971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263001972 FeS/SAM binding site; other site 306263001973 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 306263001974 putative active site [active] 306263001975 Ap4A binding site [chemical binding]; other site 306263001976 nudix motif; other site 306263001977 putative metal binding site [ion binding]; other site 306263001978 aspartate kinase; Reviewed; Region: PRK06635 306263001979 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 306263001980 putative nucleotide binding site [chemical binding]; other site 306263001981 putative catalytic residues [active] 306263001982 putative Mg ion binding site [ion binding]; other site 306263001983 putative aspartate binding site [chemical binding]; other site 306263001984 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 306263001985 putative allosteric regulatory site; other site 306263001986 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 306263001987 DNA replication regulator; Region: HobA; pfam12163 306263001988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263001989 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 306263001990 dihydropteroate synthase; Region: DHPS; TIGR01496 306263001991 substrate binding pocket [chemical binding]; other site 306263001992 dimer interface [polypeptide binding]; other site 306263001993 inhibitor binding site; inhibition site 306263001994 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 306263001995 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 306263001996 nucleotide binding pocket [chemical binding]; other site 306263001997 K-X-D-G motif; other site 306263001998 catalytic site [active] 306263001999 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 306263002000 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 306263002001 Dimer interface [polypeptide binding]; other site 306263002002 BRCT sequence motif; other site 306263002003 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 306263002004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 306263002005 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 306263002006 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263002007 active site 306263002008 nucleotide binding site [chemical binding]; other site 306263002009 HIGH motif; other site 306263002010 KMSKS motif; other site 306263002011 Riboflavin kinase; Region: Flavokinase; cl03312 306263002012 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 306263002013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263002014 S-adenosylmethionine binding site [chemical binding]; other site 306263002015 GTP-binding protein YchF; Reviewed; Region: PRK09601 306263002016 YchF GTPase; Region: YchF; cd01900 306263002017 G1 box; other site 306263002018 GTP/Mg2+ binding site [chemical binding]; other site 306263002019 Switch I region; other site 306263002020 G2 box; other site 306263002021 Switch II region; other site 306263002022 G3 box; other site 306263002023 G4 box; other site 306263002024 G5 box; other site 306263002025 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 306263002026 multifunctional aminopeptidase A; Provisional; Region: PRK00913 306263002027 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 306263002028 interface (dimer of trimers) [polypeptide binding]; other site 306263002029 Substrate-binding/catalytic site; other site 306263002030 Zn-binding sites [ion binding]; other site 306263002031 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 306263002032 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 306263002033 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263002034 active site 306263002035 TSC-22/dip/bun family; Region: TSC22; cl01853 306263002036 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 306263002037 CheB methylesterase; Region: CheB_methylest; pfam01339 306263002038 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 306263002039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306263002042 putative substrate translocation pore; other site 306263002043 hypothetical protein; Provisional; Region: PRK08445 306263002044 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 306263002045 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 306263002046 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 306263002047 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 306263002048 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 306263002049 generic binding surface II; other site 306263002050 ssDNA binding site; other site 306263002051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263002052 ATP binding site [chemical binding]; other site 306263002053 putative Mg++ binding site [ion binding]; other site 306263002054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306263002055 nucleotide binding region [chemical binding]; other site 306263002056 ATP-binding site [chemical binding]; other site 306263002057 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 306263002058 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 306263002059 ligand binding site [chemical binding]; other site 306263002060 flexible hinge region; other site 306263002061 Helix-turn-helix domains; Region: HTH; cl00088 306263002062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002063 dimer interface [polypeptide binding]; other site 306263002064 conserved gate region; other site 306263002065 putative PBP binding loops; other site 306263002066 ABC-ATPase subunit interface; other site 306263002067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002068 dimer interface [polypeptide binding]; other site 306263002069 conserved gate region; other site 306263002070 putative PBP binding loops; other site 306263002071 ABC-ATPase subunit interface; other site 306263002072 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 306263002073 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 306263002074 Walker A/P-loop; other site 306263002075 ATP binding site [chemical binding]; other site 306263002076 Q-loop/lid; other site 306263002077 ABC transporter signature motif; other site 306263002078 Walker B; other site 306263002079 D-loop; other site 306263002080 H-loop/switch region; other site 306263002081 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 306263002082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306263002083 substrate binding pocket [chemical binding]; other site 306263002084 membrane-bound complex binding site; other site 306263002085 hinge residues; other site 306263002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002087 metabolite-proton symporter; Region: 2A0106; TIGR00883 306263002088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 306263002090 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 306263002091 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 306263002092 active site 306263002093 dimer interface [polypeptide binding]; other site 306263002094 metal binding site [ion binding]; metal-binding site 306263002095 Mechanosensitive ion channel; Region: MS_channel; pfam00924 306263002096 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 306263002097 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 306263002098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263002099 FeS/SAM binding site; other site 306263002100 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 306263002101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002102 Walker B motif; other site 306263002103 arginine finger; other site 306263002104 Peptidase family M41; Region: Peptidase_M41; pfam01434 306263002105 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 306263002106 MPT binding site; other site 306263002107 trimer interface [polypeptide binding]; other site 306263002108 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 306263002109 active site residue [active] 306263002110 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 306263002111 active site residue [active] 306263002112 heat shock protein 90; Provisional; Region: PRK05218 306263002113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263002114 ATP binding site [chemical binding]; other site 306263002115 Mg2+ binding site [ion binding]; other site 306263002116 G-X-G motif; other site 306263002117 CrcB-like protein; Region: CRCB; cl09114 306263002118 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 306263002119 putative acyl-acceptor binding pocket; other site 306263002120 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 306263002121 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 306263002122 putative active site [active] 306263002123 catalytic triad [active] 306263002124 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 306263002125 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 306263002126 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 306263002127 ATP binding site [chemical binding]; other site 306263002128 active site 306263002129 substrate binding site [chemical binding]; other site 306263002130 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 306263002131 C-terminal peptidase (prc); Region: prc; TIGR00225 306263002132 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 306263002133 protein binding site [polypeptide binding]; other site 306263002134 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 306263002135 Catalytic dyad [active] 306263002136 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 306263002137 Clp amino terminal domain; Region: Clp_N; pfam02861 306263002138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002139 Walker A motif; other site 306263002140 ATP binding site [chemical binding]; other site 306263002141 Walker B motif; other site 306263002142 arginine finger; other site 306263002143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002144 Walker A motif; other site 306263002145 ATP binding site [chemical binding]; other site 306263002146 Walker B motif; other site 306263002147 arginine finger; other site 306263002148 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 306263002149 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 306263002150 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 306263002151 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 306263002152 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 306263002153 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 306263002154 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 306263002155 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 306263002156 putative substrate-binding site; other site 306263002157 nickel binding site [ion binding]; other site 306263002158 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263002159 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263002160 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 306263002161 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263002162 active site 306263002163 HIGH motif; other site 306263002164 nucleotide binding site [chemical binding]; other site 306263002165 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 306263002166 active site 306263002167 KMSKS motif; other site 306263002168 YGGT family; Region: YGGT; cl00508 306263002169 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 306263002170 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 306263002171 N-acetyl-D-glucosamine binding site [chemical binding]; other site 306263002172 catalytic residue [active] 306263002173 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 306263002174 Walker A motif; other site 306263002175 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 306263002176 active site 306263002177 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 306263002178 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 306263002179 active site 306263002180 HIGH motif; other site 306263002181 KMSKS motif; other site 306263002182 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 306263002183 tRNA binding surface [nucleotide binding]; other site 306263002184 anticodon binding site; other site 306263002185 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 306263002186 putative tRNA-binding site [nucleotide binding]; other site 306263002187 dimer interface [polypeptide binding]; other site 306263002188 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 306263002189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 306263002190 YceI-like domain; Region: YceI; cl01001 306263002191 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 306263002192 Ligand Binding Site [chemical binding]; other site 306263002193 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 306263002194 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 306263002195 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 306263002196 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263002197 Rhomboid family; Region: Rhomboid; cl11446 306263002198 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306263002199 catalytic core [active] 306263002200 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 306263002201 aspartate racemase; Region: asp_race; TIGR00035 306263002202 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 306263002203 DNA binding site [nucleotide binding] 306263002204 Int/Topo IB signature motif; other site 306263002205 active site 306263002206 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 306263002207 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 306263002208 hinge; other site 306263002209 active site 306263002210 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 306263002211 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 306263002212 dimer interface [polypeptide binding]; other site 306263002213 putative functional site; other site 306263002214 putative MPT binding site; other site 306263002215 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 306263002216 SAF domain; Region: SAF; cl00555 306263002217 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 306263002218 Flavoprotein; Region: Flavoprotein; cl08021 306263002219 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 306263002220 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 306263002221 active site 306263002222 (T/H)XGH motif; other site 306263002223 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 306263002224 thymidylate kinase; Validated; Region: tmk; PRK00698 306263002225 TMP-binding site; other site 306263002226 ATP-binding site [chemical binding]; other site 306263002227 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 306263002228 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 306263002229 dimer interface [polypeptide binding]; other site 306263002230 motif 1; other site 306263002231 active site 306263002232 motif 2; other site 306263002233 motif 3; other site 306263002234 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 306263002235 anticodon binding site; other site 306263002236 arginine decarboxylase; Provisional; Region: PRK05354 306263002237 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 306263002238 dimer interface [polypeptide binding]; other site 306263002239 active site 306263002240 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263002241 catalytic residues [active] 306263002242 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 306263002243 serine O-acetyltransferase; Region: cysE; TIGR01172 306263002244 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 306263002245 trimer interface [polypeptide binding]; other site 306263002246 active site 306263002247 substrate binding site [chemical binding]; other site 306263002248 CoA binding site [chemical binding]; other site 306263002249 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 306263002250 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 306263002251 active site 306263002252 homodimer interface [polypeptide binding]; other site 306263002253 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 306263002254 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263002255 catalytic residue [active] 306263002256 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 306263002257 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 306263002258 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 306263002259 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 306263002260 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 306263002261 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 306263002262 Walker A/P-loop; other site 306263002263 ATP binding site [chemical binding]; other site 306263002264 Q-loop/lid; other site 306263002265 ABC transporter signature motif; other site 306263002266 Walker B; other site 306263002267 D-loop; other site 306263002268 H-loop/switch region; other site 306263002269 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 306263002270 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 306263002271 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 306263002272 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 306263002273 ANP binding site [chemical binding]; other site 306263002274 Substrate Binding Site II [chemical binding]; other site 306263002275 Substrate Binding Site I [chemical binding]; other site 306263002276 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 306263002277 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 306263002278 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 306263002279 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 306263002280 active site 306263002281 HslU subunit interaction site [polypeptide binding]; other site 306263002282 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 306263002283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002284 Walker A motif; other site 306263002285 ATP binding site [chemical binding]; other site 306263002286 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263002287 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 306263002288 GTPase Era; Reviewed; Region: era; PRK00089 306263002289 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 306263002290 G1 box; other site 306263002291 GTP/Mg2+ binding site [chemical binding]; other site 306263002292 Switch I region; other site 306263002293 G2 box; other site 306263002294 Switch II region; other site 306263002295 G3 box; other site 306263002296 G4 box; other site 306263002297 G5 box; other site 306263002298 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 306263002299 Flagellar protein FliS; Region: FliS; cl00654 306263002300 flagellar capping protein; Provisional; Region: PRK12765 306263002301 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 306263002302 flagellar capping protein; Provisional; Region: PRK12765 306263002303 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 306263002304 FlaG protein; Region: FlaG; cl00591 306263002305 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 306263002306 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 306263002307 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 306263002308 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 306263002309 domain interfaces; other site 306263002310 active site 306263002311 prolyl-tRNA synthetase; Provisional; Region: PRK09194 306263002312 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 306263002313 dimer interface [polypeptide binding]; other site 306263002314 motif 1; other site 306263002315 active site 306263002316 motif 2; other site 306263002317 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 306263002318 putative deacylase active site [active] 306263002319 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 306263002320 active site 306263002321 motif 3; other site 306263002322 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 306263002323 anticodon binding site; other site 306263002324 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 306263002325 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 306263002326 tRNA; other site 306263002327 putative tRNA binding site [nucleotide binding]; other site 306263002328 putative NADP binding site [chemical binding]; other site 306263002329 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 306263002330 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 306263002331 substrate binding pocket [chemical binding]; other site 306263002332 chain length determination region; other site 306263002333 substrate-Mg2+ binding site; other site 306263002334 catalytic residues [active] 306263002335 aspartate-rich region 1; other site 306263002336 active site lid residues [active] 306263002337 aspartate-rich region 2; other site 306263002338 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 306263002339 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 306263002340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263002341 motif II; other site 306263002342 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 306263002343 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 306263002344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002345 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 306263002346 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 306263002347 DNA binding residues [nucleotide binding] 306263002348 putative dimer interface [polypeptide binding]; other site 306263002349 chaperone protein DnaJ; Provisional; Region: PRK14299 306263002350 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306263002351 HSP70 interaction site [polypeptide binding]; other site 306263002352 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 306263002353 substrate binding site [polypeptide binding]; other site 306263002354 dimer interface [polypeptide binding]; other site 306263002355 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 306263002356 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 306263002357 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 306263002358 protein binding site [polypeptide binding]; other site 306263002359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 306263002360 protein binding site [polypeptide binding]; other site 306263002361 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263002362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263002363 active site 306263002364 phosphorylation site [posttranslational modification] 306263002365 intermolecular recognition site; other site 306263002366 dimerization interface [polypeptide binding]; other site 306263002367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306263002368 DNA binding site [nucleotide binding] 306263002369 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 306263002370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306263002371 dimer interface [polypeptide binding]; other site 306263002372 phosphorylation site [posttranslational modification] 306263002373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263002374 ATP binding site [chemical binding]; other site 306263002375 Mg2+ binding site [ion binding]; other site 306263002376 G-X-G motif; other site 306263002377 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 306263002378 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263002379 Family description; Region: UvrD_C_2; cl15862 306263002380 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 306263002381 dimer interface [polypeptide binding]; other site 306263002382 catalytic triad [active] 306263002383 peroxidatic and resolving cysteines [active] 306263002384 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 306263002385 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 306263002386 Helix-turn-helix domains; Region: HTH; cl00088 306263002387 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 306263002388 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 306263002389 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 306263002390 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 306263002391 dimerization interface [polypeptide binding]; other site 306263002392 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 306263002393 ATP binding site [chemical binding]; other site 306263002394 Hydrogenase formation hypA family; Region: HypD; cl12072 306263002395 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 306263002396 HupF/HypC family; Region: HupF_HypC; cl00394 306263002397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263002398 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 306263002399 Acylphosphatase; Region: Acylphosphatase; cl00551 306263002400 HypF finger; Region: zf-HYPF; pfam07503 306263002401 HypF finger; Region: zf-HYPF; pfam07503 306263002402 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 306263002403 Protein of unknown function DUF45; Region: DUF45; cl00636 306263002404 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 306263002405 MatE; Region: MatE; cl10513 306263002406 MatE; Region: MatE; cl10513 306263002407 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263002408 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263002409 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14269 306263002410 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 306263002411 Walker A/P-loop; other site 306263002412 ATP binding site [chemical binding]; other site 306263002413 Q-loop/lid; other site 306263002414 ABC transporter signature motif; other site 306263002415 Walker B; other site 306263002416 D-loop; other site 306263002417 H-loop/switch region; other site 306263002418 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 306263002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002420 dimer interface [polypeptide binding]; other site 306263002421 conserved gate region; other site 306263002422 putative PBP binding loops; other site 306263002423 ABC-ATPase subunit interface; other site 306263002424 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 306263002425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002426 dimer interface [polypeptide binding]; other site 306263002427 conserved gate region; other site 306263002428 putative PBP binding loops; other site 306263002429 ABC-ATPase subunit interface; other site 306263002430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 306263002431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263002432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263002433 active site 306263002434 phosphorylation site [posttranslational modification] 306263002435 intermolecular recognition site; other site 306263002436 dimerization interface [polypeptide binding]; other site 306263002437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306263002438 DNA binding site [nucleotide binding] 306263002439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 306263002440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263002441 ATP binding site [chemical binding]; other site 306263002442 Mg2+ binding site [ion binding]; other site 306263002443 G-X-G motif; other site 306263002444 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 306263002445 Ferritin-like domain; Region: Ferritin; pfam00210 306263002446 ferroxidase diiron center [ion binding]; other site 306263002447 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 306263002448 Catalytic site [active] 306263002449 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 306263002450 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 306263002451 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 306263002452 active site residue [active] 306263002453 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 306263002454 heme-binding residues [chemical binding]; other site 306263002455 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 306263002456 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 306263002457 heme-binding residues [chemical binding]; other site 306263002458 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 306263002459 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 306263002460 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 306263002461 catalytic residues [active] 306263002462 ResB-like family; Region: ResB; pfam05140 306263002463 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 306263002464 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 306263002465 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 306263002466 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 306263002467 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 306263002468 trimer interface [polypeptide binding]; other site 306263002469 active site 306263002470 UDP-GlcNAc binding site [chemical binding]; other site 306263002471 lipid binding site [chemical binding]; lipid-binding site 306263002472 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 306263002473 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 306263002474 putative valine binding site [chemical binding]; other site 306263002475 dimer interface [polypeptide binding]; other site 306263002476 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 306263002477 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 306263002478 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 306263002479 PYR/PP interface [polypeptide binding]; other site 306263002480 dimer interface [polypeptide binding]; other site 306263002481 TPP binding site [chemical binding]; other site 306263002482 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 306263002483 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 306263002484 TPP-binding site [chemical binding]; other site 306263002485 dimer interface [polypeptide binding]; other site 306263002486 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 306263002487 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 306263002488 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 306263002489 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 306263002490 TPP-binding site [chemical binding]; other site 306263002491 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 306263002492 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 306263002493 dimer interface [polypeptide binding]; other site 306263002494 PYR/PP interface [polypeptide binding]; other site 306263002495 TPP binding site [chemical binding]; other site 306263002496 substrate binding site [chemical binding]; other site 306263002497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 306263002498 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 306263002499 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 306263002500 malate dehydrogenase; Reviewed; Region: PRK06223 306263002501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002502 NAD(P) binding site [chemical binding]; other site 306263002503 LDH/MDH dimer interface [polypeptide binding]; other site 306263002504 substrate binding site [chemical binding]; other site 306263002505 Protein of unknown function; Region: DUF3971; pfam13116 306263002506 AsmA-like C-terminal region; Region: AsmA_2; cl15864 306263002507 YceG-like family; Region: YceG; pfam02618 306263002508 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 306263002509 dimerization interface [polypeptide binding]; other site 306263002510 ferrous iron transporter FeoB; Region: feoB; TIGR00437 306263002511 DNA gyrase subunit A; Validated; Region: PRK05560 306263002512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263002513 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 306263002514 alternative start site for ftsK 306263002515 lagellar hook-associated protein FlgL; Provisional; Region: PRK14692 306263002516 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 306263002517 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 306263002518 integrase; Provisional; Region: PRK09692 306263002519 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 306263002520 active site 306263002521 Int/Topo IB signature motif; other site 306263002522 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 306263002523 Replication initiation factor; Region: Rep_trans; pfam02486 306263002524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 306263002525 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 306263002526 active site 306263002527 substrate binding site [chemical binding]; other site 306263002528 catalytic site [active] 306263002529 Uncharacterized conserved protein [Function unknown]; Region: COG4748 306263002530 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 306263002531 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 306263002532 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 306263002533 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 306263002534 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 306263002535 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 306263002536 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 306263002537 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 306263002538 Phage capsid family; Region: Phage_capsid; pfam05065 306263002539 phosphodiesterase; Provisional; Region: PRK12704 306263002540 Phage-related protein [Function unknown]; Region: COG4695; cl01923 306263002541 Phage portal protein; Region: Phage_portal; pfam04860 306263002542 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 306263002543 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 306263002544 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 306263002545 Phage Terminase; Region: Terminase_1; pfam03354 306263002546 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 306263002547 Predicted transcriptional regulator [Transcription]; Region: COG2378 306263002548 Helix-turn-helix domains; Region: HTH; cl00088 306263002549 WYL domain; Region: WYL; cl14852 306263002550 Protein of unknown function DUF91; Region: DUF91; cl00709 306263002551 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 306263002552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002553 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 306263002554 Walker A motif; other site 306263002555 ATP binding site [chemical binding]; other site 306263002556 Walker B motif; other site 306263002557 arginine finger; other site 306263002558 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 306263002559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263002560 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 306263002561 DNA polymerase III PolC; Validated; Region: polC; PRK00448 306263002562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263002563 Protein of unknown function DUF91; Region: DUF91; cl00709 306263002564 KWG Leptospira; Region: KWG; pfam07656 306263002565 Protein of unknown function DUF262; Region: DUF262; cl14890 306263002566 Protein of unknown function DUF262; Region: DUF262; cl14890 306263002567 Protein of unknown function DUF262; Region: DUF262; cl14890 306263002568 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 306263002569 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 306263002570 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 306263002571 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 306263002572 generic binding surface II; other site 306263002573 generic binding surface I; other site 306263002574 DJ-1 family protein; Region: not_thiJ; TIGR01383 306263002575 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 306263002576 conserved cys residue [active] 306263002577 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 306263002578 N-carbamolyputrescine amidase; Region: PLN02747 306263002579 putative active site; other site 306263002580 catalytic triad [active] 306263002581 putative dimer interface [polypeptide binding]; other site 306263002582 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 306263002583 Cation efflux family; Region: Cation_efflux; cl00316 306263002584 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 306263002585 agmatine deiminase; Region: agmatine_aguA; TIGR03380 306263002586 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 306263002587 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 306263002588 homodimer interface [polypeptide binding]; other site 306263002589 NAD synthase; Region: NAD_synthase; pfam02540 306263002590 NAD binding pocket [chemical binding]; other site 306263002591 ATP binding pocket [chemical binding]; other site 306263002592 Mg binding site [ion binding]; other site 306263002593 active-site loop [active] 306263002594 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 306263002595 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 306263002596 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 306263002597 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 306263002598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263002599 catalytic residue [active] 306263002600 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 306263002601 Ligand binding site; other site 306263002602 oligomer interface; other site 306263002603 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 306263002604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306263002605 substrate binding pocket [chemical binding]; other site 306263002606 membrane-bound complex binding site; other site 306263002607 hinge residues; other site 306263002608 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 306263002609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002610 dimer interface [polypeptide binding]; other site 306263002611 conserved gate region; other site 306263002612 putative PBP binding loops; other site 306263002613 ABC-ATPase subunit interface; other site 306263002614 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 306263002615 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 306263002616 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 306263002617 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 306263002618 DsbD alpha interface [polypeptide binding]; other site 306263002619 catalytic residues [active] 306263002620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 306263002621 MOSC domain; Region: MOSC; pfam03473 306263002622 3-alpha domain; Region: 3-alpha; pfam03475 306263002623 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 306263002624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306263002625 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 306263002626 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 306263002627 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 306263002628 ligand binding site [chemical binding]; other site 306263002629 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 306263002630 AAA domain; Region: AAA_13; pfam13166 306263002631 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 306263002632 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 306263002633 active site 306263002634 intersubunit interface [polypeptide binding]; other site 306263002635 zinc binding site [ion binding]; other site 306263002636 Na+ binding site [ion binding]; other site 306263002637 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 306263002638 PPIC-type PPIASE domain; Region: Rotamase; cl08278 306263002639 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 306263002640 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 306263002641 minor groove reading motif; other site 306263002642 helix-hairpin-helix signature motif; other site 306263002643 substrate binding pocket [chemical binding]; other site 306263002644 active site 306263002645 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 306263002646 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 306263002647 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 306263002648 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 306263002649 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 306263002650 Walker A/P-loop; other site 306263002651 ATP binding site [chemical binding]; other site 306263002652 Q-loop/lid; other site 306263002653 ABC transporter signature motif; other site 306263002654 Walker B; other site 306263002655 D-loop; other site 306263002656 H-loop/switch region; other site 306263002657 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 306263002658 FtsX-like permease family; Region: FtsX; cl15850 306263002659 macrolide transporter subunit MacA; Provisional; Region: PRK11578 306263002660 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 306263002661 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 306263002662 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 306263002663 dimer interface [polypeptide binding]; other site 306263002664 FMN binding site [chemical binding]; other site 306263002665 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 306263002666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002667 putative substrate translocation pore; other site 306263002668 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 306263002669 putative acyl-acceptor binding pocket; other site 306263002670 AMP-binding enzyme; Region: AMP-binding; cl15778 306263002671 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 306263002672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306263002673 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 306263002674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002675 Flagellin N-methylase; Region: FliB; cl00497 306263002676 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 306263002677 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 306263002678 nucleotide binding site/active site [active] 306263002679 HIT family signature motif; other site 306263002680 catalytic residue [active] 306263002681 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 306263002682 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 306263002683 active site residue [active] 306263002684 Phosphate transporter family; Region: PHO4; cl00396 306263002685 Phosphate transporter family; Region: PHO4; cl00396 306263002686 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 306263002687 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 306263002688 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 306263002689 active site 306263002690 hydrophilic channel; other site 306263002691 dimerization interface [polypeptide binding]; other site 306263002692 catalytic residues [active] 306263002693 active site lid [active] 306263002694 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 306263002695 GatB domain; Region: GatB_Yqey; cl11497 306263002696 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 306263002697 active site 306263002698 substrate binding site [chemical binding]; other site 306263002699 Mg2+ binding site [ion binding]; other site 306263002700 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 306263002701 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 306263002702 dimer interface [polypeptide binding]; other site 306263002703 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 306263002704 heat-inducible transcription repressor; Provisional; Region: PRK03911 306263002705 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 306263002706 DHH family; Region: DHH; pfam01368 306263002707 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 306263002708 FHIPEP family; Region: FHIPEP; pfam00771 306263002709 Rrf2 family protein; Region: rrf2_super; TIGR00738 306263002710 Helix-turn-helix domains; Region: HTH; cl00088 306263002711 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 306263002712 16S/18S rRNA binding site [nucleotide binding]; other site 306263002713 S13e-L30e interaction site [polypeptide binding]; other site 306263002714 25S rRNA binding site [nucleotide binding]; other site 306263002715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 306263002716 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 306263002717 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 306263002718 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 306263002719 NodB motif; other site 306263002720 putative active site [active] 306263002721 putative catalytic site [active] 306263002722 Zn binding site [ion binding]; other site 306263002723 ketol-acid reductoisomerase; Provisional; Region: PRK05479 306263002724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002725 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 306263002726 Exoribonuclease R [Transcription]; Region: VacB; COG0557 306263002727 RNB domain; Region: RNB; pfam00773 306263002728 DNA polymerase III subunit delta; Validated; Region: PRK08487 306263002729 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 306263002730 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 306263002731 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 306263002732 dimer interface [polypeptide binding]; other site 306263002733 ssDNA binding site [nucleotide binding]; other site 306263002734 tetramer (dimer of dimers) interface [polypeptide binding]; other site 306263002735 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 306263002736 MarC family integral membrane protein; Region: MarC; cl00919 306263002737 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 306263002738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002739 FliW protein; Region: FliW; cl00740 306263002740 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 306263002741 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 306263002742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002743 Walker A motif; other site 306263002744 ATP binding site [chemical binding]; other site 306263002745 Walker B motif; other site 306263002746 arginine finger; other site 306263002747 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 306263002748 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263002749 dimer interface [polypeptide binding]; other site 306263002750 putative CheW interface [polypeptide binding]; other site 306263002751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 306263002752 PAS domain; Region: PAS_9; pfam13426 306263002753 putative active site [active] 306263002754 heme pocket [chemical binding]; other site 306263002755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 306263002756 PAS fold; Region: PAS_3; pfam08447 306263002757 putative active site [active] 306263002758 heme pocket [chemical binding]; other site 306263002759 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263002760 threonine dehydratase; Provisional; Region: PRK08526 306263002761 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 306263002762 tetramer interface [polypeptide binding]; other site 306263002763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263002764 catalytic residue [active] 306263002765 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 306263002766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306263002768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 306263002769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 306263002770 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 306263002771 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 306263002772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002773 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 306263002774 NAD(P) binding site [chemical binding]; other site 306263002775 active site 306263002776 DsrC like protein; Region: DsrC; cl01101 306263002777 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 306263002778 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 306263002779 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 306263002780 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 306263002781 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 306263002782 DNA binding site [nucleotide binding] 306263002783 active site 306263002784 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 306263002785 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 306263002786 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 306263002787 dimerization interface 3.5A [polypeptide binding]; other site 306263002788 active site 306263002789 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 306263002790 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 306263002791 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 306263002792 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 306263002793 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 306263002794 catalytic residue [active] 306263002795 putative FPP diphosphate binding site; other site 306263002796 putative FPP binding hydrophobic cleft; other site 306263002797 dimer interface [polypeptide binding]; other site 306263002798 putative IPP diphosphate binding site; other site 306263002799 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 306263002800 Flavoprotein; Region: Flavoprotein; cl08021 306263002801 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 306263002802 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 306263002803 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 306263002804 Substrate binding site; other site 306263002805 Mg++ binding site; other site 306263002806 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 306263002807 active site 306263002808 substrate binding site [chemical binding]; other site 306263002809 CoA binding site [chemical binding]; other site 306263002810 FliP family; Region: FliP; cl00593 306263002811 Membrane transport protein; Region: Mem_trans; cl09117 306263002812 chorismate binding enzyme; Region: Chorismate_bind; cl10555 306263002813 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 306263002814 substrate-cofactor binding pocket; other site 306263002815 homodimer interface [polypeptide binding]; other site 306263002816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263002817 catalytic residue [active] 306263002818 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 306263002819 Glutamine amidotransferase class-I; Region: GATase; pfam00117 306263002820 glutamine binding [chemical binding]; other site 306263002821 catalytic triad [active] 306263002822 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 306263002823 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 306263002824 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 306263002825 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 306263002826 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 306263002827 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 306263002828 Cupin domain; Region: Cupin_2; cl09118 306263002829 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 306263002830 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 306263002831 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 306263002832 RimM N-terminal domain; Region: RimM; pfam01782 306263002833 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 306263002834 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 306263002835 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 306263002836 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 306263002837 signal recognition particle protein; Provisional; Region: PRK10867 306263002838 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 306263002839 P loop; other site 306263002840 GTP binding site [chemical binding]; other site 306263002841 Signal peptide binding domain; Region: SRP_SPB; pfam02978 306263002842 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306263002843 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 306263002844 active site 306263002845 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 306263002846 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 306263002847 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 306263002848 Putative zinc ribbon domain; Region: DUF164; pfam02591 306263002849 Uncharacterized conserved protein [Function unknown]; Region: COG0327 306263002850 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 306263002851 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 306263002852 dimer interface [polypeptide binding]; other site 306263002853 motif 1; other site 306263002854 active site 306263002855 motif 2; other site 306263002856 motif 3; other site 306263002857 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 306263002858 AIR carboxylase; Region: AIRC; cl00310 306263002859 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 306263002860 Peptidase family U32; Region: Peptidase_U32; cl03113 306263002861 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 306263002862 glutamine synthetase, type I; Region: GlnA; TIGR00653 306263002863 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 306263002864 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 306263002865 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 306263002866 active site 306263002867 NTP binding site [chemical binding]; other site 306263002868 metal binding triad [ion binding]; metal-binding site 306263002869 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 306263002870 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 306263002871 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 306263002872 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 306263002873 putative active site [active] 306263002874 putative substrate binding site [chemical binding]; other site 306263002875 putative cosubstrate binding site; other site 306263002876 catalytic site [active] 306263002877 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 306263002878 NapD protein; Region: NapD; cl01163 306263002879 FOG: WD40 repeat [General function prediction only]; Region: COG2319 306263002880 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 306263002881 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 306263002882 4Fe-4S binding domain; Region: Fer4_5; pfam12801 306263002883 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 306263002884 4Fe-4S binding domain; Region: Fer4; cl02805 306263002885 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 306263002886 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 306263002887 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 306263002888 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263002889 molybdopterin cofactor binding site; other site 306263002890 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263002891 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 306263002892 molybdopterin cofactor binding site; other site 306263002893 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 306263002894 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 306263002895 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 306263002896 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 306263002897 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 306263002898 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 306263002899 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 306263002900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306263002901 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 306263002902 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306263002903 DNA binding residues [nucleotide binding] 306263002904 polyphosphate kinase; Provisional; Region: PRK05443 306263002905 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 306263002906 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 306263002907 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 306263002908 putative domain interface [polypeptide binding]; other site 306263002909 putative active site [active] 306263002910 catalytic site [active] 306263002911 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 306263002912 putative domain interface [polypeptide binding]; other site 306263002913 putative active site [active] 306263002914 catalytic site [active] 306263002915 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 306263002916 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485 306263002917 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303 306263002918 ThiC family; Region: ThiC; cl08031 306263002919 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 306263002920 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 306263002921 active site 306263002922 substrate binding site [chemical binding]; other site 306263002923 catalytic site [active] 306263002924 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 306263002925 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 306263002926 substrate binding site [chemical binding]; other site 306263002927 hexamer interface [polypeptide binding]; other site 306263002928 metal binding site [ion binding]; metal-binding site 306263002929 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 306263002930 Ion channel; Region: Ion_trans_2; cl11596 306263002931 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 306263002932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002933 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 306263002934 Protein of unknown function (DUF465); Region: DUF465; cl01070 306263002935 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263002936 dimer interface [polypeptide binding]; other site 306263002937 putative CheW interface [polypeptide binding]; other site 306263002938 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 306263002939 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 306263002940 dimer interface [polypeptide binding]; other site 306263002941 ADP-ribose binding site [chemical binding]; other site 306263002942 active site 306263002943 nudix motif; other site 306263002944 metal binding site [ion binding]; metal-binding site 306263002945 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 306263002946 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 306263002947 ring oligomerisation interface [polypeptide binding]; other site 306263002948 ATP/Mg binding site [chemical binding]; other site 306263002949 stacking interactions; other site 306263002950 hinge regions; other site 306263002951 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 306263002952 oligomerisation interface [polypeptide binding]; other site 306263002953 mobile loop; other site 306263002954 roof hairpin; other site 306263002955 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 306263002956 30S subunit binding site; other site 306263002957 3-methyladenine DNA glycosylase; Provisional; Region: PRK13913 306263002958 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 306263002959 minor groove reading motif; other site 306263002960 helix-hairpin-helix signature motif; other site 306263002961 active site 306263002962 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 306263002963 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 306263002964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263002965 ATP binding site [chemical binding]; other site 306263002966 putative Mg++ binding site [ion binding]; other site 306263002967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306263002968 nucleotide binding region [chemical binding]; other site 306263002969 ATP-binding site [chemical binding]; other site 306263002970 TRCF domain; Region: TRCF; cl04088 306263002971 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 306263002972 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 306263002973 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263002974 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 306263002975 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 306263002976 Lipopolysaccharide-assembly; Region: LptE; cl01125 306263002977 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 306263002978 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 306263002979 HIGH motif; other site 306263002980 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 306263002981 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263002982 active site 306263002983 KMSKS motif; other site 306263002984 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 306263002985 tRNA binding surface [nucleotide binding]; other site 306263002986 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 306263002987 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 306263002988 Protein export membrane protein; Region: SecD_SecF; cl14618 306263002989 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 306263002990 Protein export membrane protein; Region: SecD_SecF; cl14618 306263002991 Preprotein translocase subunit; Region: YajC; cl00806 306263002992 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 306263002993 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 306263002994 active site 306263002995 catalytic triad [active] 306263002996 S-adenosylmethionine synthetase; Validated; Region: PRK05250 306263002997 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 306263002998 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 306263002999 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 306263003000 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 306263003001 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 306263003002 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 306263003003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003004 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 306263003005 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 306263003006 active site 306263003007 Zn binding site [ion binding]; other site 306263003008 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 306263003009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263003010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263003011 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 306263003012 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 306263003013 active site 306263003014 Global regulator protein family; Region: CsrA; cl00670 306263003015 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 306263003016 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 306263003017 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 306263003018 SmpB-tmRNA interface; other site 306263003019 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 306263003020 catalytic residues [active] 306263003021 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 306263003022 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 306263003023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263003024 Walker A motif; other site 306263003025 ATP binding site [chemical binding]; other site 306263003026 Walker B motif; other site 306263003027 arginine finger; other site 306263003028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263003029 Walker A motif; other site 306263003030 ATP binding site [chemical binding]; other site 306263003031 Walker B motif; other site 306263003032 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 306263003033 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 306263003034 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 306263003035 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 306263003036 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 306263003037 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 306263003038 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 306263003039 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 306263003040 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 306263003041 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 306263003042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 306263003043 ferrochelatase; Reviewed; Region: hemH; PRK00035 306263003044 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 306263003045 C-terminal domain interface [polypeptide binding]; other site 306263003046 active site 306263003047 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 306263003048 active site 306263003049 N-terminal domain interface [polypeptide binding]; other site 306263003050 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 306263003051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003052 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 306263003053 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 306263003054 inhibitor-cofactor binding pocket; inhibition site 306263003055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003056 catalytic residue [active] 306263003057 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 306263003058 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 306263003059 motif 1; other site 306263003060 active site 306263003061 motif 2; other site 306263003062 motif 3; other site 306263003063 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 306263003064 DHHA1 domain; Region: DHHA1; pfam02272 306263003065 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 306263003066 Maf-like protein; Region: Maf; pfam02545 306263003067 active site 306263003068 dimer interface [polypeptide binding]; other site 306263003069 Transglycosylase; Region: Transgly; cl07896 306263003070 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 306263003071 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 306263003072 TMAO/DMSO reductase; Reviewed; Region: PRK05363 306263003073 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 306263003074 Moco binding site; other site 306263003075 metal coordination site [ion binding]; other site 306263003076 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 306263003077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003078 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 306263003079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 306263003080 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 306263003081 metal-binding site [ion binding] 306263003082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306263003083 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263003084 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 306263003085 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 306263003086 Transcriptional regulator; Region: Transcrip_reg; cl00361 306263003087 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 306263003088 active site 306263003089 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 306263003090 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 306263003091 Uncharacterized conserved protein [Function unknown]; Region: COG2966 306263003092 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 306263003093 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 306263003094 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 306263003095 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 306263003096 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 306263003097 active site 306263003098 HIGH motif; other site 306263003099 KMSK motif region; other site 306263003100 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306263003101 tRNA binding surface [nucleotide binding]; other site 306263003102 anticodon binding site; other site 306263003103 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 306263003104 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 306263003105 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 306263003106 catalytic site [active] 306263003107 G-X2-G-X-G-K; other site 306263003108 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 306263003109 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306263003110 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 306263003111 Walker A/P-loop; other site 306263003112 ATP binding site [chemical binding]; other site 306263003113 Q-loop/lid; other site 306263003114 ABC transporter signature motif; other site 306263003115 Walker B; other site 306263003116 D-loop; other site 306263003117 H-loop/switch region; other site 306263003118 elongation factor Ts; Provisional; Region: tsf; PRK09377 306263003119 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 306263003120 Elongation factor TS; Region: EF_TS; pfam00889 306263003121 Elongation factor TS; Region: EF_TS; pfam00889 306263003122 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 306263003123 rRNA interaction site [nucleotide binding]; other site 306263003124 S8 interaction site; other site 306263003125 putative laminin-1 binding site; other site 306263003126 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 306263003127 Cytochrome c; Region: Cytochrom_C; cl11414 306263003128 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 306263003129 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 306263003130 Qi binding site; other site 306263003131 intrachain domain interface; other site 306263003132 interchain domain interface [polypeptide binding]; other site 306263003133 heme bH binding site [chemical binding]; other site 306263003134 heme bL binding site [chemical binding]; other site 306263003135 Qo binding site; other site 306263003136 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 306263003137 interchain domain interface [polypeptide binding]; other site 306263003138 intrachain domain interface; other site 306263003139 Qi binding site; other site 306263003140 Qo binding site; other site 306263003141 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 306263003142 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 306263003143 iron-sulfur cluster [ion binding]; other site 306263003144 [2Fe-2S] cluster binding site [ion binding]; other site 306263003145 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 306263003146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003147 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 306263003148 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 306263003149 Lumazine binding domain; Region: Lum_binding; pfam00677 306263003150 Lumazine binding domain; Region: Lum_binding; pfam00677 306263003151 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 306263003152 PspC domain; Region: PspC; cl00864 306263003153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306263003154 dimer interface [polypeptide binding]; other site 306263003155 phosphorylation site [posttranslational modification] 306263003156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263003157 ATP binding site [chemical binding]; other site 306263003158 Mg2+ binding site [ion binding]; other site 306263003159 G-X-G motif; other site 306263003160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263003161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263003162 active site 306263003163 phosphorylation site [posttranslational modification] 306263003164 intermolecular recognition site; other site 306263003165 dimerization interface [polypeptide binding]; other site 306263003166 Helix-turn-helix domains; Region: HTH; cl00088 306263003167 DNA binding site [nucleotide binding] 306263003168 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 306263003169 octamerization interface [polypeptide binding]; other site 306263003170 diferric-oxygen binding site [ion binding]; other site 306263003171 SprT homologues; Region: SprT; cl01182 306263003172 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 306263003173 octamerization interface [polypeptide binding]; other site 306263003174 diferric-oxygen binding site [ion binding]; other site 306263003175 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 306263003176 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 306263003177 Cytochrome c; Region: Cytochrom_C; cl11414 306263003178 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 306263003179 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 306263003180 putative ligand binding site [chemical binding]; other site 306263003181 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 306263003182 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 306263003183 putative ligand binding site [chemical binding]; other site 306263003184 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 306263003185 TM-ABC transporter signature motif; other site 306263003186 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 306263003187 TM-ABC transporter signature motif; other site 306263003188 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 306263003189 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 306263003190 Walker A/P-loop; other site 306263003191 ATP binding site [chemical binding]; other site 306263003192 Q-loop/lid; other site 306263003193 ABC transporter signature motif; other site 306263003194 Walker B; other site 306263003195 D-loop; other site 306263003196 H-loop/switch region; other site 306263003197 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 306263003198 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 306263003199 Walker A/P-loop; other site 306263003200 ATP binding site [chemical binding]; other site 306263003201 Q-loop/lid; other site 306263003202 ABC transporter signature motif; other site 306263003203 Walker B; other site 306263003204 D-loop; other site 306263003205 H-loop/switch region; other site 306263003206 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 306263003207 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 306263003208 GTP-binding protein LepA; Provisional; Region: PRK05433 306263003209 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 306263003210 G1 box; other site 306263003211 putative GEF interaction site [polypeptide binding]; other site 306263003212 GTP/Mg2+ binding site [chemical binding]; other site 306263003213 Switch I region; other site 306263003214 G2 box; other site 306263003215 G3 box; other site 306263003216 Switch II region; other site 306263003217 G4 box; other site 306263003218 G5 box; other site 306263003219 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 306263003220 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 306263003221 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 306263003222 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 306263003223 MatE; Region: MatE; cl10513 306263003224 MatE; Region: MatE; cl10513 306263003225 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 306263003226 active site 306263003227 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 306263003228 thiamine phosphate binding site [chemical binding]; other site 306263003229 active site 306263003230 pyrophosphate binding site [ion binding]; other site 306263003231 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 306263003232 substrate binding site [chemical binding]; other site 306263003233 multimerization interface [polypeptide binding]; other site 306263003234 ATP binding site [chemical binding]; other site 306263003235 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 306263003236 substrate binding site [chemical binding]; other site 306263003237 dimer interface [polypeptide binding]; other site 306263003238 ATP binding site [chemical binding]; other site 306263003239 Low molecular weight phosphatase family; Region: LMWPc; cd00115 306263003240 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 306263003241 active site 306263003242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 306263003243 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 306263003244 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 306263003245 dimerization interface [polypeptide binding]; other site 306263003246 active site 306263003247 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 306263003248 dimer interface [polypeptide binding]; other site 306263003249 active site 306263003250 Schiff base residues; other site 306263003251 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 306263003252 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 306263003253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263003254 FeS/SAM binding site; other site 306263003255 HemN C-terminal domain; Region: HemN_C; pfam06969 306263003256 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 306263003257 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 306263003258 Cysteine-rich domain; Region: CCG; pfam02754 306263003259 Cysteine-rich domain; Region: CCG; pfam02754 306263003260 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 306263003261 alanine racemase; Reviewed; Region: alr; PRK00053 306263003262 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263003263 catalytic residue [active] 306263003264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 306263003265 Protein of unknown function (DUF461); Region: DUF461; cl01071 306263003266 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 306263003267 Cu(I) binding site [ion binding]; other site 306263003268 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 306263003269 FtsX-like permease family; Region: FtsX; cl15850 306263003270 LPP20 lipoprotein; Region: LPP20; cl15824 306263003271 DNA gyrase subunit A; Validated; Region: PRK05560 306263003272 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 306263003273 CAP-like domain; other site 306263003274 active site 306263003275 primary dimer interface [polypeptide binding]; other site 306263003276 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003277 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003278 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003279 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003280 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003281 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 306263003282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263003283 active site 306263003284 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 306263003285 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 306263003286 transmembrane helices; other site 306263003287 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 306263003288 thiamine phosphate binding site [chemical binding]; other site 306263003289 active site 306263003290 pyrophosphate binding site [ion binding]; other site 306263003291 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 306263003292 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263003293 FeS/SAM binding site; other site 306263003294 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 306263003295 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 306263003296 ThiS interaction site; other site 306263003297 putative active site [active] 306263003298 tetramer interface [polypeptide binding]; other site 306263003299 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 306263003300 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 306263003301 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 306263003302 putative ATP binding site [chemical binding]; other site 306263003303 putative substrate interface [chemical binding]; other site 306263003304 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 306263003305 thiS-thiF/thiG interaction site; other site 306263003306 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 306263003307 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 306263003308 metal binding site [ion binding]; metal-binding site 306263003309 dimer interface [polypeptide binding]; other site 306263003310 LysE type translocator; Region: LysE; cl00565 306263003311 NAD-dependent deacetylase; Provisional; Region: PRK00481 306263003312 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 306263003313 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 306263003314 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263003315 Walker A/P-loop; other site 306263003316 ATP binding site [chemical binding]; other site 306263003317 Q-loop/lid; other site 306263003318 ABC transporter signature motif; other site 306263003319 Walker B; other site 306263003320 D-loop; other site 306263003321 H-loop/switch region; other site 306263003322 Smr domain; Region: Smr; cl02619 306263003323 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 306263003324 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 306263003325 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263003326 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306263003327 Predicted amidohydrolase [General function prediction only]; Region: COG0388 306263003328 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 306263003329 active site 306263003330 catalytic triad [active] 306263003331 dimer interface [polypeptide binding]; other site 306263003332 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 306263003333 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 306263003334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 306263003335 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 306263003336 active site 306263003337 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 306263003338 Amidase; Region: Amidase; cl11426 306263003339 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 306263003340 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263003341 active site 306263003342 HIGH motif; other site 306263003343 nucleotide binding site [chemical binding]; other site 306263003344 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 306263003345 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 306263003346 active site 306263003347 KMSKS motif; other site 306263003348 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 306263003349 tRNA binding surface [nucleotide binding]; other site 306263003350 anticodon binding site; other site 306263003351 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 306263003352 Competence-damaged protein; Region: CinA; cl00666 306263003353 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 306263003354 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 306263003355 catalytic residues [active] 306263003356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306263003357 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 306263003358 Walker A/P-loop; other site 306263003359 ATP binding site [chemical binding]; other site 306263003360 Q-loop/lid; other site 306263003361 ABC transporter signature motif; other site 306263003362 Walker B; other site 306263003363 D-loop; other site 306263003364 H-loop/switch region; other site 306263003365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 306263003366 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 306263003367 FtsX-like permease family; Region: FtsX; cl15850 306263003368 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 306263003369 FtsX-like permease family; Region: FtsX; cl15850 306263003370 Predicted membrane protein [Function unknown]; Region: COG4393 306263003371 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 306263003372 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 306263003373 Fe2+ transport protein; Region: Iron_transport; cl01377 306263003374 Iron permease FTR1 family; Region: FTR1; cl00475 306263003375 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 306263003376 homodimer interface [polypeptide binding]; other site 306263003377 substrate-cofactor binding pocket; other site 306263003378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003379 catalytic residue [active] 306263003380 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 306263003381 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 306263003382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003383 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 306263003384 SurA N-terminal domain; Region: SurA_N_3; cl07813 306263003385 PPIC-type PPIASE domain; Region: Rotamase; cl08278 306263003386 cell division protein FtsA; Region: ftsA; TIGR01174 306263003387 Cell division protein FtsA; Region: FtsA; cl11496 306263003388 Cell division protein FtsA; Region: FtsA; cl11496 306263003389 cell division protein FtsZ; Validated; Region: PRK09330 306263003390 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 306263003391 nucleotide binding site [chemical binding]; other site 306263003392 SulA interaction site; other site 306263003393 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 306263003394 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 306263003395 active site 306263003396 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 306263003397 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 306263003398 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 306263003399 primosome assembly protein PriA; Validated; Region: PRK05580 306263003400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263003401 ATP binding site [chemical binding]; other site 306263003402 putative Mg++ binding site [ion binding]; other site 306263003403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263003404 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 306263003405 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 306263003406 excinuclease ABC subunit B; Provisional; Region: PRK05298 306263003407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263003408 ATP binding site [chemical binding]; other site 306263003409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306263003410 nucleotide binding region [chemical binding]; other site 306263003411 ATP-binding site [chemical binding]; other site 306263003412 Ultra-violet resistance protein B; Region: UvrB; pfam12344 306263003413 UvrB/uvrC motif; Region: UVR; pfam02151 306263003414 elongation factor P; Validated; Region: PRK00529 306263003415 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 306263003416 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 306263003417 RNA binding site [nucleotide binding]; other site 306263003418 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 306263003419 RNA binding site [nucleotide binding]; other site 306263003420 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 306263003421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003422 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 306263003423 putative L-serine binding site [chemical binding]; other site 306263003424 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 306263003425 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 306263003426 RNA binding site [nucleotide binding]; other site 306263003427 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 306263003428 RNA binding site [nucleotide binding]; other site 306263003429 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306263003430 RNA binding site [nucleotide binding]; other site 306263003431 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306263003432 RNA binding site [nucleotide binding]; other site 306263003433 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306263003434 RNA binding site [nucleotide binding]; other site 306263003435 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306263003436 RNA binding site [nucleotide binding]; other site 306263003437 LytB protein; Region: LYTB; cl00507 306263003438 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 306263003439 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 306263003440 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 306263003441 hinge; other site 306263003442 active site 306263003443 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 306263003444 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 306263003445 putative tRNA-binding site [nucleotide binding]; other site 306263003446 B3/4 domain; Region: B3_4; cl11458 306263003447 tRNA synthetase B5 domain; Region: B5; cl08394 306263003448 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 306263003449 dimer interface [polypeptide binding]; other site 306263003450 motif 1; other site 306263003451 motif 3; other site 306263003452 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 306263003453 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 306263003454 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 306263003455 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 306263003456 dimer interface [polypeptide binding]; other site 306263003457 motif 1; other site 306263003458 active site 306263003459 motif 2; other site 306263003460 motif 3; other site 306263003461 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 306263003462 nucleotide binding site/active site [active] 306263003463 HIT family signature motif; other site 306263003464 catalytic residue [active] 306263003465 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 306263003466 active site 306263003467 substrate-binding site [chemical binding]; other site 306263003468 metal-binding site [ion binding] 306263003469 ATP binding site [chemical binding]; other site 306263003470 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 306263003471 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 306263003472 active site 306263003473 catalytic residues [active] 306263003474 metal binding site [ion binding]; metal-binding site 306263003475 homodimer binding site [polypeptide binding]; other site 306263003476 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 306263003477 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 306263003478 carboxyltransferase (CT) interaction site; other site 306263003479 biotinylation site [posttranslational modification]; other site 306263003480 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 306263003481 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 306263003482 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 306263003483 ATP synthase subunit C; Region: ATP-synt_C; cl00466 306263003484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 306263003485 PAS domain; Region: PAS_9; pfam13426 306263003486 putative active site [active] 306263003487 heme pocket [chemical binding]; other site 306263003488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 306263003489 PAS domain; Region: PAS_9; pfam13426 306263003490 putative active site [active] 306263003491 heme pocket [chemical binding]; other site 306263003492 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263003493 dimer interface [polypeptide binding]; other site 306263003494 putative CheW interface [polypeptide binding]; other site 306263003495 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 306263003496 dihydroorotase; Provisional; Region: PRK08417 306263003497 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 306263003498 active site 306263003499 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 306263003500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003501 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 306263003502 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 306263003503 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 306263003504 GatB domain; Region: GatB_Yqey; cl11497 306263003505 ATP synthase A chain; Region: ATP-synt_A; cl00413 306263003506 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 306263003507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003508 DNA repair protein RadA; Provisional; Region: PRK11823 306263003509 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263003510 Walker A motif; other site 306263003511 ATP binding site [chemical binding]; other site 306263003512 Walker B motif; other site 306263003513 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 306263003514 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 306263003515 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 306263003516 P loop; other site 306263003517 GTP binding site [chemical binding]; other site 306263003518 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 306263003519 catalytic residues [active] 306263003520 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 306263003521 phosphodiesterase; Provisional; Region: PRK12704 306263003522 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 306263003523 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 306263003524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 306263003525 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 306263003526 Competence protein; Region: Competence; cl00471 306263003527 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 306263003528 FAD binding domain; Region: FAD_binding_4; pfam01565 306263003529 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 306263003530 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263003531 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 306263003532 MgtE intracellular N domain; Region: MgtE_N; cl15244 306263003533 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 306263003534 Divalent cation transporter; Region: MgtE; cl00786 306263003535 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 306263003536 dimer interface [polypeptide binding]; other site 306263003537 catalytic triad [active] 306263003538 peroxidatic and resolving cysteines [active] 306263003539 replicative DNA helicase; Provisional; Region: PRK08506 306263003540 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 306263003541 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 306263003542 Walker A motif; other site 306263003543 ATP binding site [chemical binding]; other site 306263003544 Walker B motif; other site 306263003545 DNA binding loops [nucleotide binding] 306263003546 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 306263003547 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 306263003548 dimer interface [polypeptide binding]; other site 306263003549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003550 catalytic residue [active] 306263003551 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 306263003552 IHF - DNA interface [nucleotide binding]; other site 306263003553 IHF dimer interface [polypeptide binding]; other site 306263003554 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 306263003555 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 306263003556 putative active site [active] 306263003557 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003558 active site 306263003559 flagellin modification protein A; Provisional; Region: PRK09186 306263003560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003561 NAD(P) binding site [chemical binding]; other site 306263003562 active site 306263003563 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 306263003564 ligand binding site; other site 306263003565 tetramer interface; other site 306263003566 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 306263003567 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 306263003568 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 306263003569 Substrate binding site; other site 306263003570 metal-binding site 306263003571 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 306263003572 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 306263003573 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 306263003574 putative active site [active] 306263003575 putative substrate binding site [chemical binding]; other site 306263003576 putative cosubstrate binding site; other site 306263003577 catalytic site [active] 306263003578 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 306263003579 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 306263003580 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 306263003581 active site 306263003582 homodimer interface [polypeptide binding]; other site 306263003583 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 306263003584 NeuB family; Region: NeuB; cl00496 306263003585 SAF domain; Region: SAF; cl00555 306263003586 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 306263003587 active site 306263003588 substrate binding site [chemical binding]; other site 306263003589 cosubstrate binding site; other site 306263003590 catalytic site [active] 306263003591 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 306263003592 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 306263003593 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 306263003594 NAD binding site [chemical binding]; other site 306263003595 substrate binding site [chemical binding]; other site 306263003596 active site 306263003597 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003598 active site 306263003599 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003601 active site 306263003602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003603 active site 306263003604 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003605 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003606 active site 306263003607 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 306263003608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003609 active site 306263003610 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003611 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 306263003612 putative metal binding site; other site 306263003613 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 306263003614 Substrate binding site; other site 306263003615 metal-binding site 306263003616 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 306263003617 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 306263003618 putative acyl-acceptor binding pocket; other site 306263003619 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 306263003620 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 306263003621 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 306263003622 putative active site [active] 306263003623 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 306263003624 active site 306263003625 catalytic site [active] 306263003626 substrate binding site [chemical binding]; other site 306263003627 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 306263003628 UDP-glucose-4-epimerase; Region: galE; TIGR01179 306263003629 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 306263003630 NAD binding site [chemical binding]; other site 306263003631 homodimer interface [polypeptide binding]; other site 306263003632 active site 306263003633 substrate binding site [chemical binding]; other site 306263003634 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306263003635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263003636 Walker A/P-loop; other site 306263003637 ATP binding site [chemical binding]; other site 306263003638 Q-loop/lid; other site 306263003639 ABC transporter signature motif; other site 306263003640 Walker B; other site 306263003641 D-loop; other site 306263003642 H-loop/switch region; other site 306263003643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306263003644 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 306263003645 putative ADP-binding pocket [chemical binding]; other site 306263003646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306263003647 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 306263003648 putative ADP-binding pocket [chemical binding]; other site 306263003649 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 306263003650 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 306263003651 putative ADP-binding pocket [chemical binding]; other site 306263003652 Bacterial sugar transferase; Region: Bac_transf; cl00939 306263003653 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 306263003654 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 306263003655 putative trimer interface [polypeptide binding]; other site 306263003656 putative CoA binding site [chemical binding]; other site 306263003657 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 306263003658 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 306263003659 inhibitor-cofactor binding pocket; inhibition site 306263003660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003661 catalytic residue [active] 306263003662 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 306263003663 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 306263003664 NAD(P) binding site [chemical binding]; other site 306263003665 homodimer interface [polypeptide binding]; other site 306263003666 substrate binding site [chemical binding]; other site 306263003667 active site 306263003668 Response regulator receiver domain; Region: Response_reg; pfam00072 306263003669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263003670 active site 306263003671 phosphorylation site [posttranslational modification] 306263003672 intermolecular recognition site; other site 306263003673 dimerization interface [polypeptide binding]; other site 306263003674 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 306263003675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263003676 S-adenosylmethionine binding site [chemical binding]; other site 306263003677 FtsH Extracellular; Region: FtsH_ext; pfam06480 306263003678 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 306263003679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263003680 Walker A motif; other site 306263003681 ATP binding site [chemical binding]; other site 306263003682 Walker B motif; other site 306263003683 arginine finger; other site 306263003684 Peptidase family M41; Region: Peptidase_M41; pfam01434 306263003685 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 306263003686 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 306263003687 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 306263003688 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 306263003689 DNA polymerase IV; Reviewed; Region: PRK03103 306263003690 Y-family of DNA polymerases; Region: PolY; cl12025 306263003691 active site 306263003692 DNA binding site [nucleotide binding] 306263003693 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 306263003694 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 306263003695 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 306263003696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263003697 active site 306263003698 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 306263003699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263003700 Walker A motif; other site 306263003701 ATP binding site [chemical binding]; other site 306263003702 Walker B motif; other site 306263003703 arginine finger; other site 306263003704 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 306263003705 Domain of unknown function DUF20; Region: UPF0118; pfam01594 306263003706 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 306263003707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263003708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306263003709 putative substrate translocation pore; other site 306263003710 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 306263003711 active site 306263003712 dimerization interface [polypeptide binding]; other site 306263003713 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 306263003714 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 306263003715 VacJ like lipoprotein; Region: VacJ; cl01073 306263003716 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 306263003717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 306263003718 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 306263003719 Walker A/P-loop; other site 306263003720 ATP binding site [chemical binding]; other site 306263003721 ABC transporter; Region: ABC_tran; pfam00005 306263003722 Q-loop/lid; other site 306263003723 ABC transporter signature motif; other site 306263003724 Walker B; other site 306263003725 D-loop; other site 306263003726 H-loop/switch region; other site 306263003727 4Fe-4S binding domain; Region: Fer4; cl02805 306263003728 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 306263003729 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 306263003730 selenocysteine synthase; Provisional; Region: PRK04311 306263003731 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263003732 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 306263003733 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 306263003734 G1 box; other site 306263003735 putative GEF interaction site [polypeptide binding]; other site 306263003736 GTP/Mg2+ binding site [chemical binding]; other site 306263003737 Switch I region; other site 306263003738 G2 box; other site 306263003739 G3 box; other site 306263003740 Switch II region; other site 306263003741 G4 box; other site 306263003742 G5 box; other site 306263003743 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 306263003744 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 306263003745 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 306263003746 glutamate dehydrogenase; Provisional; Region: PRK09414 306263003747 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 306263003748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003749 NAD(P) binding pocket [chemical binding]; other site 306263003750 NMT1-like family; Region: NMT1_2; cl15260 306263003751 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 306263003752 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 306263003753 Malic enzyme, N-terminal domain; Region: malic; pfam00390 306263003754 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 306263003755 putative NAD(P) binding site [chemical binding]; other site 306263003756 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 306263003757 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 306263003758 active site 306263003759 HIGH motif; other site 306263003760 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 306263003761 active site 306263003762 KMSKS motif; other site 306263003763 SurA N-terminal domain; Region: SurA_N_3; cl07813 306263003764 PPIC-type PPIASE domain; Region: Rotamase; cl08278 306263003765 biotin carboxylase; Validated; Region: PRK08462 306263003766 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306263003767 ATP-grasp domain; Region: ATP-grasp_4; cl03087 306263003768 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 306263003769 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 306263003770 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 306263003771 carboxyltransferase (CT) interaction site; other site 306263003772 biotinylation site [posttranslational modification]; other site 306263003773 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 306263003774 trimer interface [polypeptide binding]; other site 306263003775 active site 306263003776 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 306263003777 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 306263003778 NAD(P) binding site [chemical binding]; other site 306263003779 homodimer interface [polypeptide binding]; other site 306263003780 substrate binding site [chemical binding]; other site 306263003781 active site 306263003782 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 306263003783 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 306263003784 inhibitor-cofactor binding pocket; inhibition site 306263003785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003786 catalytic residue [active] 306263003787 M28 Zn-Peptidases; Region: M28_like_3; cd05644 306263003788 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 306263003789 active site 306263003790 metal binding site [ion binding]; metal-binding site 306263003791 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 306263003792 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 306263003793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263003794 S-adenosylmethionine binding site [chemical binding]; other site 306263003795 FkbH-like domain; Region: FkbH; TIGR01686 306263003796 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263003797 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880 306263003798 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 306263003799 dimer interface [polypeptide binding]; other site 306263003800 active site 306263003801 CoA binding pocket [chemical binding]; other site 306263003802 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263003803 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263003804 potential frameshift: common BLAST hit: gi|218562909|ref|YP_002344688.1| N-acetyltransferase 306263003805 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 306263003806 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 306263003807 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 306263003808 AMP-binding enzyme; Region: AMP-binding; cl15778 306263003809 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 306263003810 active site 306263003811 cosubstrate binding site; other site 306263003812 substrate binding site [chemical binding]; other site 306263003813 catalytic site [active] 306263003814 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 306263003815 active site 306263003816 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263003817 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 306263003818 ligand binding site; other site 306263003819 tetramer interface; other site 306263003820 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 306263003821 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 306263003822 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_1; cd08821 306263003823 putative active site [active] 306263003824 putative substrate binding site [chemical binding]; other site 306263003825 putative cosubstrate binding site; other site 306263003826 catalytic site [active] 306263003827 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 306263003828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 306263003829 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 306263003830 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 306263003831 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 306263003832 substrate binding site [chemical binding]; other site 306263003833 glutamase interaction surface [polypeptide binding]; other site 306263003834 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 306263003835 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 306263003836 putative active site [active] 306263003837 oxyanion strand; other site 306263003838 catalytic triad [active] 306263003839 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 306263003840 Ligand Binding Site [chemical binding]; other site 306263003841 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 306263003842 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 306263003843 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 306263003844 Cache domain; Region: Cache_1; pfam02743 306263003845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 306263003846 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 306263003847 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263003848 dimer interface [polypeptide binding]; other site 306263003849 putative CheW interface [polypeptide binding]; other site 306263003850 peroxidase; Provisional; Region: PRK15000 306263003851 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 306263003852 dimer interface [polypeptide binding]; other site 306263003853 decamer (pentamer of dimers) interface [polypeptide binding]; other site 306263003854 catalytic triad [active] 306263003855 peroxidatic and resolving cysteines [active] 306263003856 4Fe-4S binding domain; Region: Fer4; cl02805 306263003857 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 306263003858 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 306263003859 active site 306263003860 multimer interface [polypeptide binding]; other site 306263003861 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 306263003862 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 306263003863 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 306263003864 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 306263003865 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 306263003866 dimer interface [polypeptide binding]; other site 306263003867 active site 306263003868 CoA binding pocket [chemical binding]; other site 306263003869 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 306263003870 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 306263003871 ligand binding site [chemical binding]; other site 306263003872 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 306263003873 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 306263003874 DNA polymerase I; Provisional; Region: PRK05755 306263003875 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 306263003876 active site 306263003877 metal binding site 1 [ion binding]; metal-binding site 306263003878 putative 5' ssDNA interaction site; other site 306263003879 metal binding site 3; metal-binding site 306263003880 metal binding site 2 [ion binding]; metal-binding site 306263003881 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 306263003882 putative DNA binding site [nucleotide binding]; other site 306263003883 putative metal binding site [ion binding]; other site 306263003884 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 306263003885 active site 306263003886 catalytic site [active] 306263003887 substrate binding site [chemical binding]; other site 306263003888 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 306263003889 active site 306263003890 DNA binding site [nucleotide binding] 306263003891 catalytic site [active] 306263003892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263003893 metabolite-proton symporter; Region: 2A0106; TIGR00883 306263003894 putative substrate translocation pore; other site 306263003895 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 306263003896 active site 306263003897 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 306263003898 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 306263003899 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 306263003900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003901 catalytic residue [active] 306263003902 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 306263003903 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 306263003904 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 306263003905 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 306263003906 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 306263003907 carbon starvation protein A; Provisional; Region: PRK15015 306263003908 Carbon starvation protein CstA; Region: CstA; pfam02554 306263003909 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 306263003910 Protein of unknown function (DUF466); Region: DUF466; cl01082 306263003911 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263003912 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263003913 catalytic residue [active] 306263003914 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 306263003915 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 306263003916 generic binding surface II; other site 306263003917 generic binding surface I; other site 306263003918 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 306263003919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263003920 S-adenosylmethionine binding site [chemical binding]; other site 306263003921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003922 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 306263003923 metal binding site 2 [ion binding]; metal-binding site 306263003924 putative DNA binding helix; other site 306263003925 metal binding site 1 [ion binding]; metal-binding site 306263003926 structural Zn2+ binding site [ion binding]; other site 306263003927 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 306263003928 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 306263003929 TPP-binding site; other site 306263003930 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 306263003931 PYR/PP interface [polypeptide binding]; other site 306263003932 dimer interface [polypeptide binding]; other site 306263003933 TPP binding site [chemical binding]; other site 306263003934 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 306263003935 flagellar assembly protein H; Validated; Region: fliH; PRK06669 306263003936 Flagellar assembly protein FliH; Region: FliH; pfam02108 306263003937 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 306263003938 MgtE intracellular N domain; Region: MgtE_N; cl15244 306263003939 FliG C-terminal domain; Region: FliG_C; pfam01706 306263003940 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 306263003941 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 306263003942 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 306263003943 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 306263003944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306263003945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003946 homodimer interface [polypeptide binding]; other site 306263003947 catalytic residue [active] 306263003948 Chorismate mutase type II; Region: CM_2; cl00693 306263003949 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 306263003950 Prephenate dehydratase; Region: PDT; pfam00800 306263003951 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 306263003952 putative L-Phe binding site [chemical binding]; other site 306263003953 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 306263003954 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263003955 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263003956 diaminopimelate decarboxylase; Region: lysA; TIGR01048 306263003957 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 306263003958 active site 306263003959 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263003960 substrate binding site [chemical binding]; other site 306263003961 catalytic residues [active] 306263003962 dimer interface [polypeptide binding]; other site 306263003963 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 306263003964 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 306263003965 putative active site [active] 306263003966 catalytic residue [active] 306263003967 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 306263003968 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 306263003969 5S rRNA interface [nucleotide binding]; other site 306263003970 CTC domain interface [polypeptide binding]; other site 306263003971 L16 interface [polypeptide binding]; other site 306263003972 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 306263003973 transaldolase; Provisional; Region: PRK03903 306263003974 catalytic residue [active] 306263003975 phosphoserine phosphatase SerB; Region: serB; TIGR00338 306263003976 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263003977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263003978 motif II; other site 306263003979 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 306263003980 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 306263003981 putative CheA interaction surface; other site 306263003982 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 306263003983 putative binding surface; other site 306263003984 active site 306263003985 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 306263003986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263003987 ATP binding site [chemical binding]; other site 306263003988 Mg2+ binding site [ion binding]; other site 306263003989 G-X-G motif; other site 306263003990 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 306263003991 Response regulator receiver domain; Region: Response_reg; pfam00072 306263003992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263003993 active site 306263003994 phosphorylation site [posttranslational modification] 306263003995 intermolecular recognition site; other site 306263003996 dimerization interface [polypeptide binding]; other site 306263003997 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 306263003998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263003999 Response regulator receiver domain; Region: Response_reg; pfam00072 306263004000 active site 306263004001 phosphorylation site [posttranslational modification] 306263004002 intermolecular recognition site; other site 306263004003 dimerization interface [polypeptide binding]; other site 306263004004 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 306263004005 putative active site [active] 306263004006 putative metal binding site [ion binding]; other site 306263004007 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 306263004008 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 306263004009 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 306263004010 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 306263004011 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 306263004012 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 306263004013 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 306263004014 putative catalytic site [active] 306263004015 heterotrimer interface [polypeptide binding]; other site 306263004016 CdtC interface [polypeptide binding]; other site 306263004017 CdtA interface [polypeptide binding]; other site 306263004018 putative metal binding site [ion binding]; other site 306263004019 putative phosphate binding site [ion binding]; other site 306263004020 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 306263004021 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 306263004022 putative sugar binding sites [chemical binding]; other site 306263004023 Q-X-W motif; other site 306263004024 peptidase T; Region: peptidase-T; TIGR01882 306263004025 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 306263004026 metal binding site [ion binding]; metal-binding site 306263004027 dimer interface [polypeptide binding]; other site 306263004028 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 306263004029 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 306263004030 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 306263004031 active site pocket [active] 306263004032 oxyanion hole [active] 306263004033 catalytic triad [active] 306263004034 active site nucleophile [active] 306263004035 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 306263004036 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 306263004037 Survival protein SurE; Region: SurE; cl00448 306263004038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263004039 ATP binding site [chemical binding]; other site 306263004040 substrate interface [chemical binding]; other site 306263004041 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 306263004042 CAAX protease self-immunity; Region: Abi; cl00558 306263004043 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 306263004044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263004045 Protein of unknown function (DUF452); Region: DUF452; cl01062 306263004046 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 306263004047 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263004048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263004049 catalytic residue [active] 306263004050 Sel1 repeat; Region: Sel1; cl02723 306263004051 Sel1 repeat; Region: Sel1; cl02723 306263004052 Sel1 repeat; Region: Sel1; cl02723 306263004053 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 306263004054 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 306263004055 inhibitor-cofactor binding pocket; inhibition site 306263004056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263004057 catalytic residue [active] 306263004058 AAA domain; Region: AAA_26; pfam13500 306263004059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263004060 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 306263004061 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 306263004062 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 306263004063 catalytic nucleophile [active] 306263004064 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 306263004065 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 306263004066 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306263004067 ATP-grasp domain; Region: ATP-grasp_4; cl03087 306263004068 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 306263004069 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306263004070 ATP-grasp domain; Region: ATP-grasp_4; cl03087 306263004071 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 306263004072 IMP binding site; other site 306263004073 dimer interface [polypeptide binding]; other site 306263004074 interdomain contacts; other site 306263004075 partial ornithine binding site; other site 306263004076 rod shape-determining protein MreC; Provisional; Region: PRK13922 306263004077 rod shape-determining protein MreC; Region: MreC; pfam04085 306263004078 rod shape-determining protein MreB; Provisional; Region: PRK13927 306263004079 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 306263004080 ATP binding site [chemical binding]; other site 306263004081 gelsolin binding site; other site 306263004082 profilin binding site; other site 306263004083 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 306263004084 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 306263004085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263004086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263004087 Walker A motif; other site 306263004088 ATP binding site [chemical binding]; other site 306263004089 Walker B motif; other site 306263004090 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 306263004091 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 306263004092 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 306263004093 active site 306263004094 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 306263004095 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 306263004096 Ligand Binding Site [chemical binding]; other site 306263004097 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 306263004098 catalytic triad [active] 306263004099 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 306263004100 active site 1 [active] 306263004101 dimer interface [polypeptide binding]; other site 306263004102 hexamer interface [polypeptide binding]; other site 306263004103 active site 2 [active] 306263004104 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 306263004105 homodimer interface [polypeptide binding]; other site 306263004106 substrate-cofactor binding pocket; other site 306263004107 catalytic residue [active] 306263004108 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 306263004109 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 306263004110 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 306263004111 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 306263004112 amidophosphoribosyltransferase; Provisional; Region: PRK08525 306263004113 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 306263004114 active site 306263004115 tetramer interface [polypeptide binding]; other site 306263004116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263004117 active site 306263004118 dihydrodipicolinate reductase; Provisional; Region: PRK00048 306263004119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263004120 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 306263004121 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263004122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263004123 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 306263004124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306263004125 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 306263004126 catalytic residues [active] 306263004127 Restriction endonuclease; Region: Mrr_cat; cl00516 306263004128 homoserine dehydrogenase; Provisional; Region: PRK06349 306263004129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263004130 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 306263004131 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 306263004132 aminotransferase; Validated; Region: PRK08175 306263004133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306263004134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263004135 homodimer interface [polypeptide binding]; other site 306263004136 catalytic residue [active] 306263004137 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 306263004138 Predicted methyltransferases [General function prediction only]; Region: COG0313 306263004139 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 306263004140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 306263004141 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 306263004142 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 306263004143 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 306263004144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263004145 FeS/SAM binding site; other site 306263004146 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 306263004147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263004148 FeS/SAM binding site; other site 306263004149 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 306263004150 UbiA prenyltransferase family; Region: UbiA; cl00337 306263004151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263004152 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 306263004153 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 306263004154 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 306263004155 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 306263004156 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 306263004157 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 306263004158 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 306263004159 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 306263004160 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 306263004161 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 306263004162 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 306263004163 4Fe-4S binding domain; Region: Fer4; cl02805 306263004164 NADH dehydrogenase; Region: NADHdh; cl00469 306263004165 NADH dehydrogenase subunit G; Validated; Region: PRK08493 306263004166 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 306263004167 catalytic loop [active] 306263004168 iron binding site [ion binding]; other site 306263004169 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 306263004170 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263004171 molybdopterin cofactor binding site; other site 306263004172 NADH dehydrogenase subunit G; Validated; Region: PRK08493 306263004173 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 306263004174 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 306263004175 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 306263004176 NADH dehydrogenase subunit B; Provisional; Region: PRK14817 306263004177 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 306263004178 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 306263004179 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306263004180 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 306263004181 Walker A/P-loop; other site 306263004182 ATP binding site [chemical binding]; other site 306263004183 Q-loop/lid; other site 306263004184 ABC transporter signature motif; other site 306263004185 Walker B; other site 306263004186 D-loop; other site 306263004187 H-loop/switch region; other site 306263004188 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 306263004189 Q-loop/lid; other site 306263004190 ABC transporter signature motif; other site 306263004191 Walker B; other site 306263004192 D-loop; other site 306263004193 H-loop/switch region; other site 306263004194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263004195 dimer interface [polypeptide binding]; other site 306263004196 conserved gate region; other site 306263004197 putative PBP binding loops; other site 306263004198 ABC-ATPase subunit interface; other site 306263004199 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 306263004200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263004201 dimer interface [polypeptide binding]; other site 306263004202 conserved gate region; other site 306263004203 putative PBP binding loops; other site 306263004204 ABC-ATPase subunit interface; other site 306263004205 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 306263004206 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 306263004207 BCCT family transporter; Region: BCCT; cl00569 306263004208 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 306263004209 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 306263004210 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 306263004211 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 306263004212 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 306263004213 Cysteine-rich domain; Region: CCG; pfam02754 306263004214 Cysteine-rich domain; Region: CCG; pfam02754 306263004215 L-lactate permease; Region: Lactate_perm; cl00701 306263004216 glycolate transporter; Provisional; Region: PRK09695 306263004217 Glypican; Region: Glypican; pfam01153 306263004218 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 306263004219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 306263004220 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 306263004221 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 306263004222 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 306263004223 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 306263004224 molybdopterin cofactor binding site [chemical binding]; other site 306263004225 substrate binding site [chemical binding]; other site 306263004226 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 306263004227 molybdopterin cofactor binding site; other site 306263004228 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 306263004229 Integral membrane protein TerC family; Region: TerC; cl10468 306263004230 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 306263004231 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639 306263004232 active site 306263004233 substrate binding site [chemical binding]; other site 306263004234 cosubstrate binding site; other site 306263004235 catalytic site [active] 306263004236 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 306263004237 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 306263004238 putative substrate binding site [chemical binding]; other site 306263004239 putative ATP binding site [chemical binding]; other site 306263004240 RmuC family; Region: RmuC; pfam02646 306263004241 Uncharacterized conserved protein [Function unknown]; Region: COG1432 306263004242 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 306263004243 putative metal binding site [ion binding]; other site 306263004244 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 306263004245 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 306263004246 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 306263004247 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263004248 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 306263004249 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 306263004250 active site 306263004251 catalytic residues [active] 306263004252 metal binding site [ion binding]; metal-binding site 306263004253 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 306263004254 metal binding site [ion binding]; metal-binding site 306263004255 active site 306263004256 I-site; other site 306263004257 Clp protease; Region: CLP_protease; pfam00574 306263004258 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 306263004259 oligomer interface [polypeptide binding]; other site 306263004260 active site residues [active] 306263004261 trigger factor; Provisional; Region: tig; PRK01490 306263004262 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 306263004263 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 306263004264 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 306263004265 homodecamer interface [polypeptide binding]; other site 306263004266 GTP cyclohydrolase I; Provisional; Region: PLN03044 306263004267 active site 306263004268 putative catalytic site residues [active] 306263004269 zinc binding site [ion binding]; other site 306263004270 GTP-CH-I/GFRP interaction surface; other site 306263004271 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 306263004272 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 306263004273 Walker A motif/ATP binding site; other site 306263004274 Walker B motif; other site 306263004275 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 306263004276 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263004277 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 306263004278 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263004279 catalytic residue [active] 306263004280 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 306263004281 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 306263004282 trimerization site [polypeptide binding]; other site 306263004283 active site 306263004284 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 306263004285 NifU-like domain; Region: NifU; cl00484 306263004286 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 306263004287 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 306263004288 Predicted membrane protein [Function unknown]; Region: COG2860 306263004289 UPF0126 domain; Region: UPF0126; pfam03458 306263004290 UPF0126 domain; Region: UPF0126; pfam03458 306263004291 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 306263004292 ATP-grasp domain; Region: ATP-grasp_4; cl03087 306263004293 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 306263004294 Tetramer interface [polypeptide binding]; other site 306263004295 active site 306263004296 FMN-binding site [chemical binding]; other site 306263004297 ribonuclease III; Reviewed; Region: rnc; PRK00102 306263004298 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 306263004299 dimerization interface [polypeptide binding]; other site 306263004300 active site 306263004301 metal binding site [ion binding]; metal-binding site 306263004302 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 306263004303 dsRNA binding site [nucleotide binding]; other site 306263004304 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 306263004305 RNA/DNA hybrid binding site [nucleotide binding]; other site 306263004306 active site 306263004307 tetratricopeptide repeat protein; Provisional; Region: PRK11788 306263004308 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 306263004309 Zinc-binding sites [ion binding]; other site 306263004310 zinc cluster 1 [ion binding]; other site 306263004311 putative charged binding surface; other site 306263004312 putative hydrophobic binding surface; other site 306263004313 zinc cluster 2 [ion binding]; other site 306263004314 DNA primase; Validated; Region: dnaG; PRK05667 306263004315 CHC2 zinc finger; Region: zf-CHC2; cl15369 306263004316 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 306263004317 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 306263004318 active site 306263004319 metal binding site [ion binding]; metal-binding site 306263004320 interdomain interaction site; other site 306263004321 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 306263004322 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 306263004323 Ligand Binding Site [chemical binding]; other site 306263004324 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 306263004325 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263004326 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263004327 dimer interface [polypeptide binding]; other site 306263004328 putative CheW interface [polypeptide binding]; other site 306263004329 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 306263004330 Transglycosylase; Region: Transgly; cl07896 306263004331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 306263004332 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 306263004333 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 306263004334 Bacterial Ig-like domain; Region: Big_5; cl01012 306263004335 MG2 domain; Region: A2M_N; pfam01835 306263004336 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 306263004337 Alpha-2-macroglobulin family; Region: A2M; pfam00207 306263004338 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 306263004339 surface patch; other site 306263004340 thioester region; other site 306263004341 specificity defining residues; other site 306263004342 Mechanosensitive ion channel; Region: MS_channel; pfam00924 306263004343 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 306263004344 active site clefts [active] 306263004345 zinc binding site [ion binding]; other site 306263004346 dimer interface [polypeptide binding]; other site 306263004347 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 306263004348 Preprotein translocase SecG subunit; Region: SecG; cl09123 306263004349 ribosome recycling factor; Reviewed; Region: frr; PRK00083 306263004350 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 306263004351 hinge region; other site 306263004352 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 306263004353 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263004354 active site 306263004355 RDD family; Region: RDD; cl00746 306263004356 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 306263004357 dimer interface [polypeptide binding]; other site 306263004358 putative radical transfer pathway; other site 306263004359 diiron center [ion binding]; other site 306263004360 tyrosyl radical; other site 306263004361 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 306263004362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 306263004363 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 306263004364 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 306263004365 active site 306263004366 zinc binding site [ion binding]; other site 306263004367 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 306263004368 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 306263004369 G1 box; other site 306263004370 putative GEF interaction site [polypeptide binding]; other site 306263004371 GTP/Mg2+ binding site [chemical binding]; other site 306263004372 Switch I region; other site 306263004373 G2 box; other site 306263004374 G3 box; other site 306263004375 Switch II region; other site 306263004376 G4 box; other site 306263004377 G5 box; other site 306263004378 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 306263004379 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 306263004380 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 306263004381 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12812 306263004382 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 306263004383 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 306263004384 FlgD Ig-like domain; Region: FlgD_ig; cl15790 306263004385 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 306263004386 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 306263004387 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 306263004388 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 306263004389 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 306263004390 Fic/DOC family; Region: Fic; cl00960 306263004391 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 306263004392 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 306263004393 Walker A/P-loop; other site 306263004394 ATP binding site [chemical binding]; other site 306263004395 Q-loop/lid; other site 306263004396 ABC transporter signature motif; other site 306263004397 Walker B; other site 306263004398 D-loop; other site 306263004399 H-loop/switch region; other site 306263004400 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 306263004401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263004402 dimer interface [polypeptide binding]; other site 306263004403 conserved gate region; other site 306263004404 putative PBP binding loops; other site 306263004405 ABC-ATPase subunit interface; other site 306263004406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 306263004407 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 306263004408 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 306263004409 heme-binding site [chemical binding]; other site 306263004410 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 306263004411 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 306263004412 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 306263004413 Walker A/P-loop; other site 306263004414 ATP binding site [chemical binding]; other site 306263004415 Q-loop/lid; other site 306263004416 ABC transporter signature motif; other site 306263004417 Walker B; other site 306263004418 D-loop; other site 306263004419 H-loop/switch region; other site 306263004420 haemagglutination activity domain; Region: Haemagg_act; cl05436 306263004421 Surface antigen; Region: Bac_surface_Ag; cl03097 306263004422 UGMP family protein; Validated; Region: PRK09604 306263004423 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 306263004424 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 306263004425 active site 306263004426 Zn binding site [ion binding]; other site 306263004427 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 306263004428 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 306263004429 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 306263004430 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 306263004431 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 306263004432 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 306263004433 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 306263004434 Domain of unknown function (DUF814); Region: DUF814; pfam05670 306263004435 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 306263004436 GTP binding site; other site 306263004437 Predicted permease [General function prediction only]; Region: COG2056 306263004438 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 306263004439 Dehydratase family; Region: ILVD_EDD; cl00340 306263004440 Cache domain; Region: Cache_1; pfam02743 306263004441 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263004442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263004443 dimer interface [polypeptide binding]; other site 306263004444 putative CheW interface [polypeptide binding]; other site 306263004445 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 306263004446 Cache domain; Region: Cache_1; pfam02743 306263004447 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263004448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 306263004449 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263004450 dimer interface [polypeptide binding]; other site 306263004451 putative CheW interface [polypeptide binding]; other site 306263004452 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263004453 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 306263004454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263004455 Walker A motif; other site 306263004456 ATP binding site [chemical binding]; other site 306263004457 Walker B motif; other site 306263004458 arginine finger; other site 306263004459 Protein of unknown function (DUF520); Region: DUF520; cl00723 306263004460 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 306263004461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263004462 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 306263004463 hypothetical protein; Provisional; Region: PRK04081 306263004464 LysE type translocator; Region: LysE; cl00565 306263004465 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 306263004466 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 306263004467 4Fe-4S binding domain; Region: Fer4_5; pfam12801 306263004468 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 306263004469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306263004470 Helix-turn-helix domains; Region: HTH; cl00088 306263004471 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 306263004472 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 306263004473 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 306263004474 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 306263004475 Protein export membrane protein; Region: SecD_SecF; cl14618 306263004476 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 306263004477 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 306263004478 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 306263004479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263004480 FeS/SAM binding site; other site 306263004481 Methyltransferase domain; Region: Methyltransf_31; pfam13847 306263004482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263004483 S-adenosylmethionine binding site [chemical binding]; other site 306263004484 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 306263004485 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 306263004486 lipoprotein signal peptidase; Provisional; Region: PRK14787 306263004487 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 306263004488 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 306263004489 active site 306263004490 substrate binding site [chemical binding]; other site 306263004491 metal binding site [ion binding]; metal-binding site 306263004492 recombination factor protein RarA; Reviewed; Region: PRK13342 306263004493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263004494 Walker A motif; other site 306263004495 ATP binding site [chemical binding]; other site 306263004496 Walker B motif; other site 306263004497 arginine finger; other site 306263004498 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 306263004499 Domain of unknown function (DUF305); Region: DUF305; cl15795 306263004500 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 306263004501 active site 306263004502 putative DNA-binding cleft [nucleotide binding]; other site 306263004503 dimer interface [polypeptide binding]; other site 306263004504 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 306263004505 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 306263004506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263004507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263004508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263004509 ATP binding site [chemical binding]; other site 306263004510 putative Mg++ binding site [ion binding]; other site 306263004511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263004512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263004513 multiple promoter invertase; Provisional; Region: mpi; PRK13413 306263004514 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 306263004515 catalytic residues [active] 306263004516 catalytic nucleophile [active] 306263004517 Presynaptic Site I dimer interface [polypeptide binding]; other site 306263004518 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 306263004519 Synaptic Flat tetramer interface [polypeptide binding]; other site 306263004520 Synaptic Site I dimer interface [polypeptide binding]; other site 306263004521 DNA binding site [nucleotide binding] 306263004522 ParA-like protein; Provisional; Region: PHA02518 306263004523 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306263004524 P-loop; other site 306263004525 Magnesium ion binding site [ion binding]; other site 306263004526 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 306263004527 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 306263004528 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 306263004529 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 306263004530 Type IV secretion system proteins; Region: T4SS; pfam07996 306263004531 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 306263004532 BRO family, N-terminal domain; Region: Bro-N; cl10591 306263004533 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 306263004534 VirB8 protein; Region: VirB8; cl01500 306263004535 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 306263004536 VirB7 interaction site; other site 306263004537 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 306263004538 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 306263004539 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 306263004540 Walker A motif; other site 306263004541 hexamer interface [polypeptide binding]; other site 306263004542 ATP binding site [chemical binding]; other site 306263004543 Walker B motif; other site 306263004544 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 306263004545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 306263004546 Walker A motif; other site 306263004547 ATP binding site [chemical binding]; other site 306263004548 Walker B motif; other site 306263004549 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 306263004550 TrbM; Region: TrbM; cl06455 306263004551 DNA topoisomerase III; Provisional; Region: PRK07726 306263004552 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 306263004553 active site 306263004554 putative interdomain interaction site [polypeptide binding]; other site 306263004555 putative metal-binding site [ion binding]; other site 306263004556 putative nucleotide binding site [chemical binding]; other site 306263004557 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 306263004558 domain I; other site 306263004559 DNA binding groove [nucleotide binding] 306263004560 phosphate binding site [ion binding]; other site 306263004561 domain II; other site 306263004562 domain III; other site 306263004563 nucleotide binding site [chemical binding]; other site 306263004564 catalytic site [active] 306263004565 domain IV; other site 306263004566 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 306263004567 dimer interface [polypeptide binding]; other site 306263004568 ssDNA binding site [nucleotide binding]; other site 306263004569 tetramer (dimer of dimers) interface [polypeptide binding]; other site 306263004570 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 306263004571 multiple promoter invertase; Provisional; Region: mpi; PRK13413 306263004572 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 306263004573 catalytic residues [active] 306263004574 catalytic nucleophile [active] 306263004575 Presynaptic Site I dimer interface [polypeptide binding]; other site 306263004576 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 306263004577 Synaptic Flat tetramer interface [polypeptide binding]; other site 306263004578 Synaptic Site I dimer interface [polypeptide binding]; other site 306263004579 DNA binding site [nucleotide binding] 306263004580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 306263004581 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 306263004582 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 306263004583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 306263004584 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718