-- dump date 20140619_022453 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1240471000001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1240471000002 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1240471000003 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1240471000004 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1240471000005 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1240471000006 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1240471000007 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1240471000008 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1240471000009 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1240471000010 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1240471000011 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1240471000012 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1240471000013 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1240471000014 beta subunit interaction interface [polypeptide binding]; other site 1240471000015 Walker A motif; other site 1240471000016 ATP binding site [chemical binding]; other site 1240471000017 Walker B motif; other site 1240471000018 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1240471000019 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1240471000020 core domain interface [polypeptide binding]; other site 1240471000021 delta subunit interface [polypeptide binding]; other site 1240471000022 epsilon subunit interface [polypeptide binding]; other site 1240471000023 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1240471000024 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1240471000025 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1240471000026 alpha subunit interaction interface [polypeptide binding]; other site 1240471000027 Walker A motif; other site 1240471000028 ATP binding site [chemical binding]; other site 1240471000029 Walker B motif; other site 1240471000030 inhibitor binding site; inhibition site 1240471000031 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1240471000032 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1240471000033 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1240471000034 gamma subunit interface [polypeptide binding]; other site 1240471000035 epsilon subunit interface [polypeptide binding]; other site 1240471000036 LBP interface [polypeptide binding]; other site 1240471000037 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1240471000038 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1240471000039 Substrate binding site; other site 1240471000040 Mg++ binding site; other site 1240471000041 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1240471000042 active site 1240471000043 substrate binding site [chemical binding]; other site 1240471000044 CoA binding site [chemical binding]; other site 1240471000045 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1240471000046 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1240471000047 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1240471000048 G1 box; other site 1240471000049 GTP/Mg2+ binding site [chemical binding]; other site 1240471000050 Switch I region; other site 1240471000051 G2 box; other site 1240471000052 Switch II region; other site 1240471000053 G3 box; other site 1240471000054 G4 box; other site 1240471000055 G5 box; other site 1240471000056 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1240471000057 Haemolytic domain; Region: Haemolytic; pfam01809 1240471000058 membrane protein insertase; Provisional; Region: PRK01318 1240471000059 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1240471000060 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1240471000061 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1240471000062 DNA polymerase III subunit beta; Validated; Region: PRK05643 1240471000063 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1240471000064 putative DNA binding surface [nucleotide binding]; other site 1240471000065 dimer interface [polypeptide binding]; other site 1240471000066 beta-clamp/clamp loader binding surface; other site 1240471000067 beta-clamp/translesion DNA polymerase binding surface; other site 1240471000068 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1240471000069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1240471000070 Mg2+ binding site [ion binding]; other site 1240471000071 G-X-G motif; other site 1240471000072 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1240471000073 anchoring element; other site 1240471000074 dimer interface [polypeptide binding]; other site 1240471000075 ATP binding site [chemical binding]; other site 1240471000076 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1240471000077 active site 1240471000078 putative metal-binding site [ion binding]; other site 1240471000079 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1240471000080 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1240471000081 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1240471000082 putative dimer interface [polypeptide binding]; other site 1240471000083 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1240471000084 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1240471000085 motif 1; other site 1240471000086 dimer interface [polypeptide binding]; other site 1240471000087 active site 1240471000088 motif 2; other site 1240471000089 motif 3; other site 1240471000090 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1240471000091 DALR anticodon binding domain; Region: DALR_1; pfam05746 1240471000092 superoxide dismutase; Provisional; Region: PRK10925 1240471000093 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1240471000094 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1240471000095 oligopeptidase A; Provisional; Region: PRK10911 1240471000096 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1240471000097 active site 1240471000098 Zn binding site [ion binding]; other site 1240471000099 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1240471000100 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1240471000101 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1240471000102 UbiA prenyltransferase family; Region: UbiA; pfam01040 1240471000103 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1240471000104 metal binding site 2 [ion binding]; metal-binding site 1240471000105 putative DNA binding helix; other site 1240471000106 metal binding site 1 [ion binding]; metal-binding site 1240471000107 dimer interface [polypeptide binding]; other site 1240471000108 structural Zn2+ binding site [ion binding]; other site 1240471000109 replicative DNA helicase; Provisional; Region: PRK08006 1240471000110 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1240471000111 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1240471000112 Walker A motif; other site 1240471000113 ATP binding site [chemical binding]; other site 1240471000114 Walker B motif; other site 1240471000115 DNA binding loops [nucleotide binding] 1240471000116 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1240471000117 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1240471000118 dimer interface [polypeptide binding]; other site 1240471000119 ssDNA binding site [nucleotide binding]; other site 1240471000120 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1240471000121 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1240471000122 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1240471000123 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1240471000124 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1240471000125 homotrimer interaction site [polypeptide binding]; other site 1240471000126 putative active site [active] 1240471000127 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1240471000128 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1240471000129 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1240471000130 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1240471000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1240471000132 active site 1240471000133 HIGH motif; other site 1240471000134 nucleotide binding site [chemical binding]; other site 1240471000135 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1240471000136 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1240471000137 active site 1240471000138 KMSKS motif; other site 1240471000139 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1240471000140 tRNA binding surface [nucleotide binding]; other site 1240471000141 anticodon binding site; other site 1240471000142 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1240471000143 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1240471000144 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1240471000145 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1240471000146 interface (dimer of trimers) [polypeptide binding]; other site 1240471000147 Substrate-binding/catalytic site; other site 1240471000148 Zn-binding sites [ion binding]; other site 1240471000149 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1240471000150 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1240471000151 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1240471000152 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1240471000153 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1240471000154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1240471000155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1240471000156 dimerization interface [polypeptide binding]; other site 1240471000157 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1240471000158 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1240471000159 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1240471000160 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1240471000161 ABC-ATPase subunit interface; other site 1240471000162 dimer interface [polypeptide binding]; other site 1240471000163 putative PBP binding regions; other site 1240471000164 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1240471000165 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1240471000166 Walker A/P-loop; other site 1240471000167 ATP binding site [chemical binding]; other site 1240471000168 Q-loop/lid; other site 1240471000169 ABC transporter signature motif; other site 1240471000170 Walker B; other site 1240471000171 D-loop; other site 1240471000172 H-loop/switch region; other site 1240471000173 OstA-like protein; Region: OstA; cl00844 1240471000174 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1240471000175 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1240471000176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1240471000177 BolA-like protein; Region: BolA; cl00386 1240471000178 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1240471000179 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1240471000180 hinge; other site 1240471000181 active site 1240471000182 serine endoprotease; Provisional; Region: PRK10139 1240471000183 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1240471000184 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1240471000185 protein binding site [polypeptide binding]; other site 1240471000186 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1240471000187 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1240471000188 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1240471000189 23S rRNA interface [nucleotide binding]; other site 1240471000190 L3 interface [polypeptide binding]; other site 1240471000191 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1240471000192 outer membrane lipoprotein; Provisional; Region: PRK11023 1240471000193 BON domain; Region: BON; pfam04972 1240471000194 BON domain; Region: BON; pfam04972 1240471000195 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1240471000196 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1240471000197 putative SAM binding site [chemical binding]; other site 1240471000198 putative homodimer interface [polypeptide binding]; other site 1240471000199 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1240471000200 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1240471000201 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1240471000202 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1240471000203 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1240471000204 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1240471000205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1240471000206 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1240471000207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1240471000208 DNA binding residues [nucleotide binding] 1240471000209 DNA primase; Validated; Region: dnaG; PRK05667 1240471000210 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1240471000211 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1240471000212 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1240471000213 active site 1240471000214 metal binding site [ion binding]; metal-binding site 1240471000215 interdomain interaction site; other site 1240471000216 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1240471000217 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1240471000218 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1240471000219 UGMP family protein; Validated; Region: PRK09604 1240471000220 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1240471000221 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1240471000222 Dihydroneopterin aldolase; Region: FolB; smart00905 1240471000223 active site 1240471000224 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1240471000225 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13298 1240471000226 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1240471000227 active site 1240471000228 NTP binding site [chemical binding]; other site 1240471000229 metal binding triad [ion binding]; metal-binding site 1240471000230 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1240471000231 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1240471000232 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1240471000233 putative ribose interaction site [chemical binding]; other site 1240471000234 putative ADP binding site [chemical binding]; other site 1240471000235 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1240471000236 active site 1240471000237 nucleotide binding site [chemical binding]; other site 1240471000238 HIGH motif; other site 1240471000239 KMSKS motif; other site 1240471000240 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1240471000241 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1240471000242 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1240471000243 putative acyl-acceptor binding pocket; other site 1240471000244 cystathionine beta-lyase; Provisional; Region: PRK08114 1240471000245 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1240471000246 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1240471000247 catalytic residue [active] 1240471000248 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 1240471000249 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1240471000250 oligomerisation interface [polypeptide binding]; other site 1240471000251 mobile loop; other site 1240471000252 roof hairpin; other site 1240471000253 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1240471000254 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1240471000255 ring oligomerisation interface [polypeptide binding]; other site 1240471000256 ATP/Mg binding site [chemical binding]; other site 1240471000257 stacking interactions; other site 1240471000258 hinge regions; other site 1240471000259 translation elongation factor P; Region: efp; TIGR00038 1240471000260 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1240471000261 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1240471000262 RNA binding site [nucleotide binding]; other site 1240471000263 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1240471000264 RNA binding site [nucleotide binding]; other site 1240471000265 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1240471000266 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1240471000267 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1240471000268 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1240471000269 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1240471000270 catalytic site [active] 1240471000271 putative active site [active] 1240471000272 putative substrate binding site [chemical binding]; other site 1240471000273 dimer interface [polypeptide binding]; other site 1240471000274 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1240471000275 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1240471000276 AMIN domain; Region: AMIN; pfam11741 1240471000277 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1240471000278 active site 1240471000279 metal binding site [ion binding]; metal-binding site 1240471000280 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1240471000281 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1240471000282 bacterial Hfq-like; Region: Hfq; cd01716 1240471000283 hexamer interface [polypeptide binding]; other site 1240471000284 Sm1 motif; other site 1240471000285 RNA binding site [nucleotide binding]; other site 1240471000286 Sm2 motif; other site 1240471000287 GTPase HflX; Provisional; Region: PRK11058 1240471000288 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1240471000289 HflX GTPase family; Region: HflX; cd01878 1240471000290 G1 box; other site 1240471000291 GTP/Mg2+ binding site [chemical binding]; other site 1240471000292 Switch I region; other site 1240471000293 G2 box; other site 1240471000294 G3 box; other site 1240471000295 Switch II region; other site 1240471000296 G4 box; other site 1240471000297 FtsH protease regulator HflK; Provisional; Region: PRK10930 1240471000298 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1240471000299 FtsH protease regulator HflC; Provisional; Region: PRK11029 1240471000300 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1240471000301 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1240471000302 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1240471000303 GDP-binding site [chemical binding]; other site 1240471000304 ACT binding site; other site 1240471000305 IMP binding site; other site 1240471000306 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1240471000307 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1240471000308 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1240471000309 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1240471000310 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1240471000311 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1240471000312 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1240471000313 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1240471000314 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1240471000315 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1240471000316 active site 1240471000317 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1240471000318 Surface antigen; Region: Bac_surface_Ag; pfam01103 1240471000319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1240471000320 Family of unknown function (DUF490); Region: DUF490; pfam04357 1240471000321 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1240471000322 dimer interface [polypeptide binding]; other site 1240471000323 substrate binding site [chemical binding]; other site 1240471000324 metal binding sites [ion binding]; metal-binding site 1240471000325 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1240471000326 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1240471000327 substrate binding pocket [chemical binding]; other site 1240471000328 chain length determination region; other site 1240471000329 substrate-Mg2+ binding site; other site 1240471000330 catalytic residues [active] 1240471000331 aspartate-rich region 1; other site 1240471000332 active site lid residues [active] 1240471000333 aspartate-rich region 2; other site 1240471000334 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1240471000335 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1240471000336 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1240471000337 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1240471000338 GTP1/OBG; Region: GTP1_OBG; pfam01018 1240471000339 Obg GTPase; Region: Obg; cd01898 1240471000340 G1 box; other site 1240471000341 GTP/Mg2+ binding site [chemical binding]; other site 1240471000342 Switch I region; other site 1240471000343 G2 box; other site 1240471000344 G3 box; other site 1240471000345 Switch II region; other site 1240471000346 G4 box; other site 1240471000347 G5 box; other site 1240471000348 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1240471000349 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1240471000350 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1240471000351 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1240471000352 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1240471000353 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1240471000354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1240471000355 Walker A motif; other site 1240471000356 ATP binding site [chemical binding]; other site 1240471000357 Walker B motif; other site 1240471000358 arginine finger; other site 1240471000359 Peptidase family M41; Region: Peptidase_M41; pfam01434 1240471000360 dihydropteroate synthase; Region: DHPS; TIGR01496 1240471000361 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1240471000362 substrate binding pocket [chemical binding]; other site 1240471000363 dimer interface [polypeptide binding]; other site 1240471000364 inhibitor binding site; inhibition site 1240471000365 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1240471000366 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1240471000367 active site 1240471000368 substrate binding site [chemical binding]; other site 1240471000369 metal binding site [ion binding]; metal-binding site 1240471000370 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1240471000371 NusA N-terminal domain; Region: NusA_N; pfam08529 1240471000372 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1240471000373 RNA binding site [nucleotide binding]; other site 1240471000374 homodimer interface [polypeptide binding]; other site 1240471000375 NusA-like KH domain; Region: KH_5; pfam13184 1240471000376 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1240471000377 G-X-X-G motif; other site 1240471000378 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1240471000379 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1240471000380 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1240471000381 translation initiation factor IF-2; Region: IF-2; TIGR00487 1240471000382 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1240471000383 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1240471000384 G1 box; other site 1240471000385 putative GEF interaction site [polypeptide binding]; other site 1240471000386 GTP/Mg2+ binding site [chemical binding]; other site 1240471000387 Switch I region; other site 1240471000388 G2 box; other site 1240471000389 G3 box; other site 1240471000390 Switch II region; other site 1240471000391 G4 box; other site 1240471000392 G5 box; other site 1240471000393 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1240471000394 Translation-initiation factor 2; Region: IF-2; pfam11987 1240471000395 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1240471000396 Ribosome-binding factor A; Region: RBFA; pfam02033 1240471000397 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1240471000398 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1240471000399 RNA binding site [nucleotide binding]; other site 1240471000400 active site 1240471000401 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1240471000402 16S/18S rRNA binding site [nucleotide binding]; other site 1240471000403 S13e-L30e interaction site [polypeptide binding]; other site 1240471000404 25S rRNA binding site [nucleotide binding]; other site 1240471000405 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1240471000406 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1240471000407 RNase E interface [polypeptide binding]; other site 1240471000408 trimer interface [polypeptide binding]; other site 1240471000409 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1240471000410 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1240471000411 RNase E interface [polypeptide binding]; other site 1240471000412 trimer interface [polypeptide binding]; other site 1240471000413 active site 1240471000414 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1240471000415 putative nucleic acid binding region [nucleotide binding]; other site 1240471000416 G-X-X-G motif; other site 1240471000417 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1240471000418 RNA binding site [nucleotide binding]; other site 1240471000419 domain interface; other site 1240471000420 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1240471000421 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1240471000422 ATP binding site [chemical binding]; other site 1240471000423 Mg++ binding site [ion binding]; other site 1240471000424 motif III; other site 1240471000425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1240471000426 nucleotide binding region [chemical binding]; other site 1240471000427 ATP-binding site [chemical binding]; other site 1240471000428 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1240471000429 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 1240471000430 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1240471000431 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1240471000432 putative catalytic residues [active] 1240471000433 putative nucleotide binding site [chemical binding]; other site 1240471000434 putative aspartate binding site [chemical binding]; other site 1240471000435 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1240471000436 dimer interface [polypeptide binding]; other site 1240471000437 putative threonine allosteric regulatory site; other site 1240471000438 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1240471000439 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1240471000440 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1240471000441 homoserine kinase; Provisional; Region: PRK01212 1240471000442 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1240471000443 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1240471000444 threonine synthase; Validated; Region: PRK09225 1240471000445 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1240471000446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1240471000447 catalytic residue [active] 1240471000448 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1240471000449 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1240471000450 nucleotide binding site [chemical binding]; other site 1240471000451 chaperone protein DnaJ; Provisional; Region: PRK10767 1240471000452 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1240471000453 HSP70 interaction site [polypeptide binding]; other site 1240471000454 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1240471000455 Zn binding sites [ion binding]; other site 1240471000456 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1240471000457 dimer interface [polypeptide binding]; other site 1240471000458 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1240471000459 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1240471000460 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1240471000461 active site 1240471000462 Riboflavin kinase; Region: Flavokinase; smart00904 1240471000463 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1240471000464 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1240471000465 active site 1240471000466 HIGH motif; other site 1240471000467 nucleotide binding site [chemical binding]; other site 1240471000468 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1240471000469 active site 1240471000470 KMSKS motif; other site 1240471000471 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1240471000472 tRNA binding surface [nucleotide binding]; other site 1240471000473 anticodon binding site; other site 1240471000474 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1240471000475 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1240471000476 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1240471000477 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1240471000478 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1240471000479 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1240471000480 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1240471000481 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1240471000482 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1240471000483 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1240471000484 catalytic site [active] 1240471000485 subunit interface [polypeptide binding]; other site 1240471000486 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1240471000487 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1240471000488 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1240471000489 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1240471000490 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1240471000491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1240471000492 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1240471000493 substrate binding site [chemical binding]; other site 1240471000494 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1240471000495 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1240471000496 folate binding site [chemical binding]; other site 1240471000497 NADP+ binding site [chemical binding]; other site 1240471000498 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1240471000499 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1240471000500 active site 1240471000501 metal binding site [ion binding]; metal-binding site 1240471000502 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1240471000503 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1240471000504 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1240471000505 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1240471000506 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1240471000507 SurA N-terminal domain; Region: SurA_N; pfam09312 1240471000508 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1240471000509 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1240471000510 OstA-like protein; Region: OstA; cl00844 1240471000511 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1240471000512 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1240471000513 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1240471000514 substrate binding site [chemical binding]; other site 1240471000515 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1240471000516 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1240471000517 substrate binding site [chemical binding]; other site 1240471000518 ligand binding site [chemical binding]; other site 1240471000519 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1240471000520 tartrate dehydrogenase; Region: TTC; TIGR02089 1240471000521 2-isopropylmalate synthase; Validated; Region: PRK00915 1240471000522 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1240471000523 active site 1240471000524 catalytic residues [active] 1240471000525 metal binding site [ion binding]; metal-binding site 1240471000526 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1240471000527 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1240471000528 MraW methylase family; Region: Methyltransf_5; cl17771 1240471000529 Cell division protein FtsL; Region: FtsL; cl11433 1240471000530 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1240471000531 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1240471000532 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1240471000533 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1240471000534 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1240471000535 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1240471000536 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1240471000537 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1240471000538 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1240471000539 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1240471000540 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1240471000541 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1240471000542 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1240471000543 Mg++ binding site [ion binding]; other site 1240471000544 putative catalytic motif [active] 1240471000545 putative substrate binding site [chemical binding]; other site 1240471000546 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1240471000547 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1240471000548 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1240471000549 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1240471000550 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1240471000551 active site 1240471000552 homodimer interface [polypeptide binding]; other site 1240471000553 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1240471000554 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1240471000555 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1240471000556 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1240471000557 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1240471000558 Cell division protein FtsQ; Region: FtsQ; pfam03799 1240471000559 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1240471000560 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1240471000561 Cell division protein FtsA; Region: FtsA; pfam14450 1240471000562 cell division protein FtsZ; Validated; Region: PRK09330 1240471000563 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1240471000564 nucleotide binding site [chemical binding]; other site 1240471000565 SulA interaction site; other site 1240471000566 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1240471000567 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1240471000568 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1240471000569 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1240471000570 SEC-C motif; Region: SEC-C; pfam02810 1240471000571 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1240471000572 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1240471000573 CoA-binding site [chemical binding]; other site 1240471000574 ATP-binding [chemical binding]; other site 1240471000575 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1240471000576 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1240471000577 catalytic center binding site [active] 1240471000578 ATP binding site [chemical binding]; other site 1240471000579 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1240471000580 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1240471000581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1240471000582 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1240471000583 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1240471000584 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1240471000585 E3 interaction surface; other site 1240471000586 lipoyl attachment site [posttranslational modification]; other site 1240471000587 e3 binding domain; Region: E3_binding; pfam02817 1240471000588 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1240471000589 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1240471000590 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1240471000591 dimer interface [polypeptide binding]; other site 1240471000592 TPP-binding site [chemical binding]; other site 1240471000593 penicillin-binding protein 1b; Provisional; Region: PRK14850 1240471000594 Transglycosylase; Region: Transgly; pfam00912 1240471000595 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1240471000596 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1240471000597 CTP synthetase; Validated; Region: pyrG; PRK05380 1240471000598 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1240471000599 Catalytic site [active] 1240471000600 active site 1240471000601 UTP binding site [chemical binding]; other site 1240471000602 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1240471000603 active site 1240471000604 putative oxyanion hole; other site 1240471000605 catalytic triad [active] 1240471000606 enolase; Provisional; Region: eno; PRK00077 1240471000607 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1240471000608 dimer interface [polypeptide binding]; other site 1240471000609 metal binding site [ion binding]; metal-binding site 1240471000610 substrate binding pocket [chemical binding]; other site 1240471000611 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1240471000612 Flavodoxin; Region: Flavodoxin_1; pfam00258 1240471000613 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1240471000614 FAD binding pocket [chemical binding]; other site 1240471000615 FAD binding motif [chemical binding]; other site 1240471000616 catalytic residues [active] 1240471000617 NAD binding pocket [chemical binding]; other site 1240471000618 phosphate binding motif [ion binding]; other site 1240471000619 beta-alpha-beta structure motif; other site 1240471000620 sulfite reductase subunit beta; Provisional; Region: PRK13504 1240471000621 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1240471000622 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1240471000623 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1240471000624 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1240471000625 Active Sites [active] 1240471000626 siroheme synthase; Provisional; Region: cysG; PRK10637 1240471000627 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1240471000628 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1240471000629 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1240471000630 active site 1240471000631 SAM binding site [chemical binding]; other site 1240471000632 homodimer interface [polypeptide binding]; other site 1240471000633 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1240471000634 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1240471000635 Active Sites [active] 1240471000636 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1240471000637 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1240471000638 CysD dimerization site [polypeptide binding]; other site 1240471000639 G1 box; other site 1240471000640 putative GEF interaction site [polypeptide binding]; other site 1240471000641 GTP/Mg2+ binding site [chemical binding]; other site 1240471000642 Switch I region; other site 1240471000643 G2 box; other site 1240471000644 G3 box; other site 1240471000645 Switch II region; other site 1240471000646 G4 box; other site 1240471000647 G5 box; other site 1240471000648 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1240471000649 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1240471000650 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1240471000651 ligand-binding site [chemical binding]; other site 1240471000652 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1240471000653 Septum formation initiator; Region: DivIC; cl17659 1240471000654 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1240471000655 substrate binding site; other site 1240471000656 dimer interface; other site 1240471000657 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1240471000658 homotrimer interaction site [polypeptide binding]; other site 1240471000659 zinc binding site [ion binding]; other site 1240471000660 CDP-binding sites; other site 1240471000661 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1240471000662 Peptidase family M23; Region: Peptidase_M23; pfam01551 1240471000663 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1240471000664 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1240471000665 motif 1; other site 1240471000666 active site 1240471000667 motif 2; other site 1240471000668 motif 3; other site 1240471000669 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1240471000670 carbon storage regulator; Provisional; Region: PRK01712 1240471000671 signal recognition particle protein; Provisional; Region: PRK10867 1240471000672 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1240471000673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1240471000674 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1240471000675 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1240471000676 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1240471000677 RimM N-terminal domain; Region: RimM; pfam01782 1240471000678 PRC-barrel domain; Region: PRC; pfam05239 1240471000679 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1240471000680 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1240471000681 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1240471000682 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1240471000683 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1240471000684 Chorismate mutase type II; Region: CM_2; cl00693 1240471000685 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1240471000686 prephenate dehydrogenase; Validated; Region: PRK08507 1240471000687 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1240471000688 Prephenate dehydratase; Region: PDT; pfam00800 1240471000689 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1240471000690 Outer membrane lipoprotein; Region: YfiO; pfam13525 1240471000691 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1240471000692 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1240471000693 RNA binding surface [nucleotide binding]; other site 1240471000694 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1240471000695 active site 1240471000696 protein disaggregation chaperone; Provisional; Region: PRK10865 1240471000697 Clp amino terminal domain; Region: Clp_N; pfam02861 1240471000698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1240471000699 Walker A motif; other site 1240471000700 ATP binding site [chemical binding]; other site 1240471000701 Walker B motif; other site 1240471000702 arginine finger; other site 1240471000703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1240471000704 Walker A motif; other site 1240471000705 ATP binding site [chemical binding]; other site 1240471000706 Walker B motif; other site 1240471000707 arginine finger; other site 1240471000708 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1240471000709 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1240471000710 FAD binding domain; Region: FAD_binding_4; pfam01565 1240471000711 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1240471000712 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1240471000713 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1240471000714 pantothenate kinase; Provisional; Region: PRK05439 1240471000715 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1240471000716 ATP-binding site [chemical binding]; other site 1240471000717 CoA-binding site [chemical binding]; other site 1240471000718 Mg2+-binding site [ion binding]; other site 1240471000719 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1240471000720 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1240471000721 heme binding site [chemical binding]; other site 1240471000722 ferroxidase pore; other site 1240471000723 ferroxidase diiron center [ion binding]; other site 1240471000724 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1240471000725 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1240471000726 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1240471000727 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1240471000728 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1240471000729 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1240471000730 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1240471000731 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1240471000732 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1240471000733 protein-rRNA interface [nucleotide binding]; other site 1240471000734 putative translocon binding site; other site 1240471000735 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1240471000736 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1240471000737 G-X-X-G motif; other site 1240471000738 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1240471000739 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1240471000740 23S rRNA interface [nucleotide binding]; other site 1240471000741 5S rRNA interface [nucleotide binding]; other site 1240471000742 putative antibiotic binding site [chemical binding]; other site 1240471000743 L25 interface [polypeptide binding]; other site 1240471000744 L27 interface [polypeptide binding]; other site 1240471000745 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1240471000746 putative translocon interaction site; other site 1240471000747 signal recognition particle (SRP54) interaction site; other site 1240471000748 L23 interface [polypeptide binding]; other site 1240471000749 trigger factor interaction site; other site 1240471000750 23S rRNA interface [nucleotide binding]; other site 1240471000751 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1240471000752 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1240471000753 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1240471000754 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1240471000755 RNA binding site [nucleotide binding]; other site 1240471000756 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1240471000757 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1240471000758 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1240471000759 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1240471000760 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1240471000761 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1240471000762 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1240471000763 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1240471000764 5S rRNA interface [nucleotide binding]; other site 1240471000765 L27 interface [polypeptide binding]; other site 1240471000766 23S rRNA interface [nucleotide binding]; other site 1240471000767 L5 interface [polypeptide binding]; other site 1240471000768 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1240471000769 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1240471000770 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1240471000771 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1240471000772 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1240471000773 SecY translocase; Region: SecY; pfam00344 1240471000774 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1240471000775 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1240471000776 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1240471000777 30S ribosomal protein S11; Validated; Region: PRK05309 1240471000778 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1240471000779 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1240471000780 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1240471000781 RNA binding surface [nucleotide binding]; other site 1240471000782 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1240471000783 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1240471000784 alphaNTD homodimer interface [polypeptide binding]; other site 1240471000785 alphaNTD - beta interaction site [polypeptide binding]; other site 1240471000786 alphaNTD - beta' interaction site [polypeptide binding]; other site 1240471000787 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1240471000788 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1240471000789 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1240471000790 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1240471000791 putative active site [active] 1240471000792 substrate binding site [chemical binding]; other site 1240471000793 putative cosubstrate binding site; other site 1240471000794 catalytic site [active] 1240471000795 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1240471000796 substrate binding site [chemical binding]; other site 1240471000797 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1240471000798 active site 1240471000799 catalytic residues [active] 1240471000800 metal binding site [ion binding]; metal-binding site 1240471000801 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1240471000802 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1240471000803 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1240471000804 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1240471000805 shikimate binding site; other site 1240471000806 NAD(P) binding site [chemical binding]; other site 1240471000807 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1240471000808 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1240471000809 RNA/DNA hybrid binding site [nucleotide binding]; other site 1240471000810 active site 1240471000811 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1240471000812 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1240471000813 active site 1240471000814 catalytic site [active] 1240471000815 substrate binding site [chemical binding]; other site 1240471000816 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1240471000817 dimer interface [polypeptide binding]; other site 1240471000818 active site 1240471000819 peroxidase; Provisional; Region: PRK15000 1240471000820 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1240471000821 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1240471000822 catalytic triad [active] 1240471000823 dimer interface [polypeptide binding]; other site 1240471000824 peroxidatic and resolving cysteines [active] 1240471000825 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1240471000826 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1240471000827 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1240471000828 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 1240471000829 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1240471000830 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1240471000831 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1240471000832 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1240471000833 Protein export membrane protein; Region: SecD_SecF; cl14618 1240471000834 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1240471000835 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1240471000836 catalytic motif [active] 1240471000837 Zn binding site [ion binding]; other site 1240471000838 RibD C-terminal domain; Region: RibD_C; cl17279 1240471000839 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1240471000840 homopentamer interface [polypeptide binding]; other site 1240471000841 active site 1240471000842 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1240471000843 putative RNA binding site [nucleotide binding]; other site 1240471000844 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1240471000845 tetramer interfaces [polypeptide binding]; other site 1240471000846 binuclear metal-binding site [ion binding]; other site 1240471000847 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1240471000848 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1240471000849 TPP-binding site; other site 1240471000850 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1240471000851 PYR/PP interface [polypeptide binding]; other site 1240471000852 dimer interface [polypeptide binding]; other site 1240471000853 TPP binding site [chemical binding]; other site 1240471000854 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1240471000855 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1240471000856 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1240471000857 substrate binding pocket [chemical binding]; other site 1240471000858 chain length determination region; other site 1240471000859 substrate-Mg2+ binding site; other site 1240471000860 catalytic residues [active] 1240471000861 aspartate-rich region 1; other site 1240471000862 active site lid residues [active] 1240471000863 aspartate-rich region 2; other site 1240471000864 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1240471000865 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1240471000866 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1240471000867 Ligand Binding Site [chemical binding]; other site 1240471000868 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1240471000869 active site residue [active] 1240471000870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1240471000871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1240471000872 putative substrate translocation pore; other site 1240471000873 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1240471000874 UbiA prenyltransferase family; Region: UbiA; pfam01040 1240471000875 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1240471000876 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1240471000877 Subunit I/III interface [polypeptide binding]; other site 1240471000878 Subunit III/IV interface [polypeptide binding]; other site 1240471000879 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1240471000880 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1240471000881 D-pathway; other site 1240471000882 Putative ubiquinol binding site [chemical binding]; other site 1240471000883 Low-spin heme (heme b) binding site [chemical binding]; other site 1240471000884 Putative water exit pathway; other site 1240471000885 Binuclear center (heme o3/CuB) [ion binding]; other site 1240471000886 K-pathway; other site 1240471000887 Putative proton exit pathway; other site 1240471000888 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1240471000889 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1240471000890 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1240471000891 Clp protease; Region: CLP_protease; pfam00574 1240471000892 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1240471000893 oligomer interface [polypeptide binding]; other site 1240471000894 active site residues [active] 1240471000895 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1240471000896 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1240471000897 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1240471000898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1240471000899 Walker A motif; other site 1240471000900 ATP binding site [chemical binding]; other site 1240471000901 Walker B motif; other site 1240471000902 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1240471000903 oxidative damage protection protein; Provisional; Region: PRK05408 1240471000904 adenine DNA glycosylase; Provisional; Region: PRK10880 1240471000905 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1240471000906 minor groove reading motif; other site 1240471000907 helix-hairpin-helix signature motif; other site 1240471000908 substrate binding pocket [chemical binding]; other site 1240471000909 active site 1240471000910 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1240471000911 DNA binding and oxoG recognition site [nucleotide binding] 1240471000912 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1240471000913 hypothetical protein; Validated; Region: PRK00228 1240471000914 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1240471000915 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1240471000916 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1240471000917 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1240471000918 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1240471000919 agmatinase; Region: agmatinase; TIGR01230 1240471000920 oligomer interface [polypeptide binding]; other site 1240471000921 putative active site [active] 1240471000922 Mn binding site [ion binding]; other site 1240471000923 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1240471000924 Phosphoglycerate kinase; Region: PGK; pfam00162 1240471000925 substrate binding site [chemical binding]; other site 1240471000926 hinge regions; other site 1240471000927 ADP binding site [chemical binding]; other site 1240471000928 catalytic site [active] 1240471000929 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1240471000930 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1240471000931 active site 1240471000932 intersubunit interface [polypeptide binding]; other site 1240471000933 zinc binding site [ion binding]; other site 1240471000934 Na+ binding site [ion binding]; other site 1240471000935 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1240471000936 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1240471000937 active site 1240471000938 dimer interface [polypeptide binding]; other site 1240471000939 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1240471000940 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1240471000941 Z-ring-associated protein; Provisional; Region: PRK10972 1240471000942 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1240471000943 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1240471000944 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1240471000945 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1240471000946 putative global regulator; Reviewed; Region: PRK09559 1240471000947 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1240471000948 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1240471000949 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1240471000950 RF-1 domain; Region: RF-1; pfam00472 1240471000951 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1240471000952 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1240471000953 dimer interface [polypeptide binding]; other site 1240471000954 putative anticodon binding site; other site 1240471000955 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1240471000956 motif 1; other site 1240471000957 active site 1240471000958 motif 2; other site 1240471000959 motif 3; other site 1240471000960 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1240471000961 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1240471000962 active site 1240471000963 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1240471000964 substrate binding site [chemical binding]; other site 1240471000965 catalytic residues [active] 1240471000966 dimer interface [polypeptide binding]; other site 1240471000967 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1240471000968 putative active site [active] 1240471000969 Ap4A binding site [chemical binding]; other site 1240471000970 nudix motif; other site 1240471000971 putative metal binding site [ion binding]; other site 1240471000972 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1240471000973 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1240471000974 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1240471000975 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1240471000976 AAA domain; Region: AAA_30; pfam13604 1240471000977 Family description; Region: UvrD_C_2; pfam13538 1240471000978 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1240471000979 Family description; Region: UvrD_C_2; pfam13538 1240471000980 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1240471000981 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1240471000982 trimer interface [polypeptide binding]; other site 1240471000983 active site 1240471000984 substrate binding site [chemical binding]; other site 1240471000985 CoA binding site [chemical binding]; other site 1240471000986 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1240471000987 active site 1240471000988 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1240471000989 rRNA interaction site [nucleotide binding]; other site 1240471000990 S8 interaction site; other site 1240471000991 putative laminin-1 binding site; other site 1240471000992 elongation factor Ts; Provisional; Region: tsf; PRK09377 1240471000993 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1240471000994 Elongation factor TS; Region: EF_TS; pfam00889 1240471000995 Elongation factor TS; Region: EF_TS; pfam00889 1240471000996 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1240471000997 putative nucleotide binding site [chemical binding]; other site 1240471000998 uridine monophosphate binding site [chemical binding]; other site 1240471000999 homohexameric interface [polypeptide binding]; other site 1240471001000 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1240471001001 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1240471001002 hinge region; other site 1240471001003 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1240471001004 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1240471001005 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1240471001006 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1240471001007 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1240471001008 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1240471001009 catalytic residue [active] 1240471001010 putative FPP diphosphate binding site; other site 1240471001011 putative FPP binding hydrophobic cleft; other site 1240471001012 dimer interface [polypeptide binding]; other site 1240471001013 putative IPP diphosphate binding site; other site 1240471001014 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1240471001015 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1240471001016 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1240471001017 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1240471001018 active site 1240471001019 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1240471001020 protein binding site [polypeptide binding]; other site 1240471001021 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1240471001022 protein binding site [polypeptide binding]; other site 1240471001023 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1240471001024 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1240471001025 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1240471001026 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1240471001027 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1240471001028 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1240471001029 Surface antigen; Region: Bac_surface_Ag; pfam01103 1240471001030 periplasmic chaperone; Provisional; Region: PRK10780 1240471001031 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1240471001032 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1240471001033 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1240471001034 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1240471001035 trimer interface [polypeptide binding]; other site 1240471001036 active site 1240471001037 UDP-GlcNAc binding site [chemical binding]; other site 1240471001038 lipid binding site [chemical binding]; lipid-binding site 1240471001039 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1240471001040 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1240471001041 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1240471001042 active site 1240471001043 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1240471001044 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1240471001045 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1240471001046 RNA/DNA hybrid binding site [nucleotide binding]; other site 1240471001047 active site 1240471001048 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1240471001049 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1240471001050 putative active site [active] 1240471001051 putative PHP Thumb interface [polypeptide binding]; other site 1240471001052 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1240471001053 generic binding surface I; other site 1240471001054 generic binding surface II; other site 1240471001055 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1240471001056 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1240471001057 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1240471001058 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1240471001059 Ligand Binding Site [chemical binding]; other site 1240471001060 TilS substrate binding domain; Region: TilS; pfam09179 1240471001061 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1240471001062 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1240471001063 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1240471001064 dimer interface [polypeptide binding]; other site 1240471001065 motif 1; other site 1240471001066 active site 1240471001067 motif 2; other site 1240471001068 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1240471001069 putative deacylase active site [active] 1240471001070 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1240471001071 active site 1240471001072 motif 3; other site 1240471001073 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1240471001074 anticodon binding site; other site 1240471001075 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1240471001076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1240471001077 active site 1240471001078 motif I; other site 1240471001079 motif II; other site 1240471001080 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1240471001081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1240471001082 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1240471001083 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1240471001084 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1240471001085 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1240471001086 carboxyltransferase (CT) interaction site; other site 1240471001087 biotinylation site [posttranslational modification]; other site 1240471001088 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1240471001089 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1240471001090 active site 1240471001091 trimer interface [polypeptide binding]; other site 1240471001092 dimer interface [polypeptide binding]; other site 1240471001093 rod shape-determining protein MreB; Provisional; Region: PRK13927 1240471001094 MreB and similar proteins; Region: MreB_like; cd10225 1240471001095 nucleotide binding site [chemical binding]; other site 1240471001096 Mg binding site [ion binding]; other site 1240471001097 putative protofilament interaction site [polypeptide binding]; other site 1240471001098 RodZ interaction site [polypeptide binding]; other site 1240471001099 rod shape-determining protein MreC; Provisional; Region: PRK13922 1240471001100 rod shape-determining protein MreC; Region: MreC; pfam04085 1240471001101 rod shape-determining protein MreD; Region: MreD; cl01087 1240471001102 protease TldD; Provisional; Region: tldD; PRK10735 1240471001103 peptidase PmbA; Provisional; Region: PRK11040 1240471001104 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1240471001105 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1240471001106 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1240471001107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1240471001108 Walker A motif; other site 1240471001109 ATP binding site [chemical binding]; other site 1240471001110 Walker B motif; other site 1240471001111 arginine finger; other site 1240471001112 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1240471001113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1240471001114 active site 1240471001115 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 1240471001116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1240471001117 Walker A motif; other site 1240471001118 ATP binding site [chemical binding]; other site 1240471001119 Walker B motif; other site 1240471001120 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1240471001121 arginine finger; other site 1240471001122 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1240471001123 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1240471001124 adenylate kinase; Reviewed; Region: adk; PRK00279 1240471001125 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1240471001126 AMP-binding site [chemical binding]; other site 1240471001127 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1240471001128 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1240471001129 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1240471001130 putative active site [active] 1240471001131 putative metal binding site [ion binding]; other site 1240471001132 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1240471001133 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1240471001134 active site 1240471001135 HIGH motif; other site 1240471001136 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1240471001137 KMSKS motif; other site 1240471001138 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1240471001139 tRNA binding surface [nucleotide binding]; other site 1240471001140 anticodon binding site; other site 1240471001141 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1240471001142 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1240471001143 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1240471001144 homodimer interface [polypeptide binding]; other site 1240471001145 NADP binding site [chemical binding]; other site 1240471001146 substrate binding site [chemical binding]; other site 1240471001147 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1240471001148 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1240471001149 penicillin-binding protein 2; Provisional; Region: PRK10795 1240471001150 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1240471001151 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1240471001152 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1240471001153 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1240471001154 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1240471001155 Lipopolysaccharide-assembly; Region: LptE; cl01125 1240471001156 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1240471001157 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1240471001158 HIGH motif; other site 1240471001159 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1240471001160 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1240471001161 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1240471001162 active site 1240471001163 KMSKS motif; other site 1240471001164 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1240471001165 tRNA binding surface [nucleotide binding]; other site 1240471001166 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1240471001167 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1240471001168 putative active site [active] 1240471001169 catalytic triad [active] 1240471001170 putative dimer interface [polypeptide binding]; other site 1240471001171 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1240471001172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1240471001173 Transporter associated domain; Region: CorC_HlyC; smart01091 1240471001174 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1240471001175 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1240471001176 PhoH-like protein; Region: PhoH; pfam02562 1240471001177 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1240471001178 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1240471001179 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1240471001180 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1240471001181 active site 1240471001182 dimer interface [polypeptide binding]; other site 1240471001183 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1240471001184 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1240471001185 active site 1240471001186 trimer interface [polypeptide binding]; other site 1240471001187 allosteric site; other site 1240471001188 active site lid [active] 1240471001189 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1240471001190 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1240471001191 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1240471001192 active site 1240471001193 HIGH motif; other site 1240471001194 nucleotide binding site [chemical binding]; other site 1240471001195 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1240471001196 active site 1240471001197 KMSKS motif; other site 1240471001198 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1240471001199 flavodoxin FldA; Validated; Region: PRK09267 1240471001200 acyl-CoA esterase; Provisional; Region: PRK10673 1240471001201 PGAP1-like protein; Region: PGAP1; pfam07819 1240471001202 phosphoglucomutase; Validated; Region: PRK07564 1240471001203 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1240471001204 active site 1240471001205 substrate binding site [chemical binding]; other site 1240471001206 metal binding site [ion binding]; metal-binding site 1240471001207 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1240471001208 Iron-sulfur protein interface; other site 1240471001209 proximal quinone binding site [chemical binding]; other site 1240471001210 SdhD (CybS) interface [polypeptide binding]; other site 1240471001211 proximal heme binding site [chemical binding]; other site 1240471001212 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1240471001213 SdhC subunit interface [polypeptide binding]; other site 1240471001214 proximal heme binding site [chemical binding]; other site 1240471001215 cardiolipin binding site; other site 1240471001216 Iron-sulfur protein interface; other site 1240471001217 proximal quinone binding site [chemical binding]; other site 1240471001218 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1240471001219 L-aspartate oxidase; Provisional; Region: PRK06175 1240471001220 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1240471001221 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1240471001222 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1240471001223 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1240471001224 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1240471001225 TPP-binding site [chemical binding]; other site 1240471001226 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1240471001227 dimer interface [polypeptide binding]; other site 1240471001228 PYR/PP interface [polypeptide binding]; other site 1240471001229 TPP binding site [chemical binding]; other site 1240471001230 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1240471001231 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1240471001232 E3 interaction surface; other site 1240471001233 lipoyl attachment site [posttranslational modification]; other site 1240471001234 e3 binding domain; Region: E3_binding; pfam02817 1240471001235 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1240471001236 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1240471001237 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1240471001238 CoA-ligase; Region: Ligase_CoA; pfam00549 1240471001239 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1240471001240 CoA binding domain; Region: CoA_binding; pfam02629 1240471001241 CoA-ligase; Region: Ligase_CoA; pfam00549 1240471001242 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1240471001243 TolR protein; Region: tolR; TIGR02801 1240471001244 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1240471001245 TolA C-terminal; Region: TolA; pfam06519 1240471001246 translocation protein TolB; Provisional; Region: tolB; PRK03629 1240471001247 TolB amino-terminal domain; Region: TolB_N; pfam04052 1240471001248 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1240471001249 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1240471001250 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1240471001251 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1240471001252 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1240471001253 ligand binding site [chemical binding]; other site 1240471001254 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1240471001255 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1240471001256 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1240471001257 6-phosphogluconolactonase; Provisional; Region: PRK11028 1240471001258 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1240471001259 catalytic core [active] 1240471001260 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1240471001261 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1240471001262 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1240471001263 GTP-binding protein YchF; Reviewed; Region: PRK09601 1240471001264 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1240471001265 G1 box; other site 1240471001266 GTP/Mg2+ binding site [chemical binding]; other site 1240471001267 G2 box; other site 1240471001268 Switch I region; other site 1240471001269 G3 box; other site 1240471001270 Switch II region; other site 1240471001271 G4 box; other site 1240471001272 G5 box; other site 1240471001273 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1240471001274 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1240471001275 putative active site [active] 1240471001276 catalytic residue [active] 1240471001277 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1240471001278 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1240471001279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1240471001280 active site 1240471001281 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1240471001282 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1240471001283 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1240471001284 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1240471001285 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1240471001286 RF-1 domain; Region: RF-1; pfam00472 1240471001287 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1240471001288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1240471001289 S-adenosylmethionine binding site [chemical binding]; other site 1240471001290 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1240471001291 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1240471001292 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1240471001293 active site 1240471001294 dimer interface [polypeptide binding]; other site 1240471001295 motif 1; other site 1240471001296 motif 2; other site 1240471001297 motif 3; other site 1240471001298 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1240471001299 anticodon binding site; other site 1240471001300 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1240471001301 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1240471001302 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1240471001303 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1240471001304 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1240471001305 23S rRNA binding site [nucleotide binding]; other site 1240471001306 L21 binding site [polypeptide binding]; other site 1240471001307 L13 binding site [polypeptide binding]; other site 1240471001308 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1240471001309 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1240471001310 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1240471001311 dimer interface [polypeptide binding]; other site 1240471001312 motif 1; other site 1240471001313 active site 1240471001314 motif 2; other site 1240471001315 motif 3; other site 1240471001316 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1240471001317 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1240471001318 putative tRNA-binding site [nucleotide binding]; other site 1240471001319 B3/4 domain; Region: B3_4; pfam03483 1240471001320 tRNA synthetase B5 domain; Region: B5; smart00874 1240471001321 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1240471001322 dimer interface [polypeptide binding]; other site 1240471001323 motif 1; other site 1240471001324 motif 3; other site 1240471001325 motif 2; other site 1240471001326 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1240471001327 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1240471001328 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1240471001329 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1240471001330 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1240471001331 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1240471001332 putative ABC transporter; Region: ycf24; CHL00085 1240471001333 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1240471001334 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1240471001335 Walker A/P-loop; other site 1240471001336 ATP binding site [chemical binding]; other site 1240471001337 Q-loop/lid; other site 1240471001338 ABC transporter signature motif; other site 1240471001339 Walker B; other site 1240471001340 D-loop; other site 1240471001341 H-loop/switch region; other site 1240471001342 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1240471001343 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1240471001344 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1240471001345 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1240471001346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1240471001347 catalytic residue [active] 1240471001348 Fe-S metabolism associated domain; Region: SufE; cl00951 1240471001349 murein lipoprotein; Provisional; Region: PRK15396 1240471001350 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1240471001351 Lumazine binding domain; Region: Lum_binding; pfam00677 1240471001352 Lumazine binding domain; Region: Lum_binding; pfam00677 1240471001353 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1240471001354 putative GSH binding site [chemical binding]; other site 1240471001355 catalytic residues [active] 1240471001356 ribonuclease T; Provisional; Region: PRK05168 1240471001357 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1240471001358 active site 1240471001359 catalytic site [active] 1240471001360 substrate binding site [chemical binding]; other site 1240471001361 transcriptional regulator SlyA; Provisional; Region: PRK03573 1240471001362 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1240471001363 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1240471001364 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1240471001365 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1240471001366 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1240471001367 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1240471001368 active site 1240471001369 HIGH motif; other site 1240471001370 dimer interface [polypeptide binding]; other site 1240471001371 KMSKS motif; other site 1240471001372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1240471001373 RNA binding surface [nucleotide binding]; other site 1240471001374 endonuclease III; Provisional; Region: PRK10702 1240471001375 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1240471001376 minor groove reading motif; other site 1240471001377 helix-hairpin-helix signature motif; other site 1240471001378 substrate binding pocket [chemical binding]; other site 1240471001379 active site 1240471001380 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1240471001381 Class II fumarases; Region: Fumarase_classII; cd01362 1240471001382 active site 1240471001383 tetramer interface [polypeptide binding]; other site 1240471001384 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1240471001385 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1240471001386 Flavoprotein; Region: Flavoprotein; pfam02441 1240471001387 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1240471001388 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1240471001389 Ligand binding site; other site 1240471001390 oligomer interface; other site 1240471001391 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1240471001392 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1240471001393 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1240471001394 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1240471001395 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1240471001396 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1240471001397 Walker A/P-loop; other site 1240471001398 ATP binding site [chemical binding]; other site 1240471001399 Q-loop/lid; other site 1240471001400 ABC transporter signature motif; other site 1240471001401 Walker B; other site 1240471001402 D-loop; other site 1240471001403 H-loop/switch region; other site 1240471001404 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1240471001405 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1240471001406 RNA binding site [nucleotide binding]; other site 1240471001407 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1240471001408 RNA binding site [nucleotide binding]; other site 1240471001409 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1240471001410 RNA binding site [nucleotide binding]; other site 1240471001411 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1240471001412 RNA binding site [nucleotide binding]; other site 1240471001413 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1240471001414 RNA binding site [nucleotide binding]; other site 1240471001415 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1240471001416 RNA binding site [nucleotide binding]; other site 1240471001417 cytidylate kinase; Provisional; Region: cmk; PRK00023 1240471001418 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1240471001419 CMP-binding site; other site 1240471001420 The sites determining sugar specificity; other site 1240471001421 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1240471001422 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1240471001423 hinge; other site 1240471001424 active site 1240471001425 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1240471001426 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1240471001427 catalytic residue [active] 1240471001428 seryl-tRNA synthetase; Provisional; Region: PRK05431 1240471001429 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1240471001430 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1240471001431 dimer interface [polypeptide binding]; other site 1240471001432 active site 1240471001433 motif 1; other site 1240471001434 motif 2; other site 1240471001435 motif 3; other site 1240471001436 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1240471001437 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1240471001438 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1240471001439 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1240471001440 thioredoxin reductase; Provisional; Region: PRK10262 1240471001441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1240471001442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1240471001443 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1240471001444 rRNA binding site [nucleotide binding]; other site 1240471001445 predicted 30S ribosome binding site; other site 1240471001446 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1240471001447 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1240471001448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1240471001449 DNA binding site [nucleotide binding] 1240471001450 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1240471001451 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1240471001452 catalytic residue [active] 1240471001453 manganese transport regulator MntR; Provisional; Region: PRK11050 1240471001454 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1240471001455 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1240471001456 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1240471001457 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1240471001458 Ligand Binding Site [chemical binding]; other site 1240471001459 adenylosuccinate lyase; Provisional; Region: PRK09285 1240471001460 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1240471001461 tetramer interface [polypeptide binding]; other site 1240471001462 active site 1240471001463 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1240471001464 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1240471001465 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1240471001466 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1240471001467 Walker A/P-loop; other site 1240471001468 ATP binding site [chemical binding]; other site 1240471001469 Q-loop/lid; other site 1240471001470 ABC transporter signature motif; other site 1240471001471 Walker B; other site 1240471001472 D-loop; other site 1240471001473 H-loop/switch region; other site 1240471001474 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1240471001475 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1240471001476 FtsX-like permease family; Region: FtsX; pfam02687 1240471001477 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1240471001478 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1240471001479 nucleotide binding site/active site [active] 1240471001480 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1240471001481 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1240471001482 active site 1240471001483 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1240471001484 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1240471001485 thymidylate kinase; Validated; Region: tmk; PRK00698 1240471001486 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1240471001487 TMP-binding site; other site 1240471001488 ATP-binding site [chemical binding]; other site 1240471001489 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1240471001490 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1240471001491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1240471001492 catalytic residue [active] 1240471001493 acyl carrier protein; Provisional; Region: acpP; PRK00982 1240471001494 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1240471001495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1240471001496 NAD(P) binding site [chemical binding]; other site 1240471001497 active site 1240471001498 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1240471001499 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1240471001500 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1240471001501 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1240471001502 dimer interface [polypeptide binding]; other site 1240471001503 active site 1240471001504 CoA binding pocket [chemical binding]; other site 1240471001505 putative phosphate acyltransferase; Provisional; Region: PRK05331 1240471001506 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1240471001507 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1240471001508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1240471001509 RNA binding surface [nucleotide binding]; other site 1240471001510 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1240471001511 active site 1240471001512 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1240471001513 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1240471001514 homodimer interface [polypeptide binding]; other site 1240471001515 oligonucleotide binding site [chemical binding]; other site 1240471001516 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1240471001517 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1240471001518 putative acyl-acceptor binding pocket; other site 1240471001519 L,D-transpeptidase; Provisional; Region: PRK10260 1240471001520 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1240471001521 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1240471001522 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1240471001523 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 1240471001524 heat shock protein HspQ; Provisional; Region: PRK14129 1240471001525 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1240471001526 active site 1 [active] 1240471001527 dimer interface [polypeptide binding]; other site 1240471001528 active site 2 [active] 1240471001529 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1240471001530 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1240471001531 putative dimer interface [polypeptide binding]; other site 1240471001532 putative anticodon binding site; other site 1240471001533 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1240471001534 homodimer interface [polypeptide binding]; other site 1240471001535 motif 1; other site 1240471001536 motif 2; other site 1240471001537 active site 1240471001538 motif 3; other site 1240471001539 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1240471001540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1240471001541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1240471001542 homodimer interface [polypeptide binding]; other site 1240471001543 catalytic residue [active] 1240471001544 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1240471001545 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1240471001546 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1240471001547 NAD binding site [chemical binding]; other site 1240471001548 homotetramer interface [polypeptide binding]; other site 1240471001549 homodimer interface [polypeptide binding]; other site 1240471001550 substrate binding site [chemical binding]; other site 1240471001551 active site 1240471001552 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1240471001553 dimerization interface [polypeptide binding]; other site 1240471001554 active site 1240471001555 anthranilate synthase component I; Provisional; Region: PRK13564 1240471001556 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1240471001557 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1240471001558 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1240471001559 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1240471001560 glutamine binding [chemical binding]; other site 1240471001561 catalytic triad [active] 1240471001562 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1240471001563 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1240471001564 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1240471001565 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1240471001566 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1240471001567 active site 1240471001568 ribulose/triose binding site [chemical binding]; other site 1240471001569 phosphate binding site [ion binding]; other site 1240471001570 substrate (anthranilate) binding pocket [chemical binding]; other site 1240471001571 product (indole) binding pocket [chemical binding]; other site 1240471001572 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1240471001573 active site 1240471001574 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1240471001575 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1240471001576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1240471001577 catalytic residue [active] 1240471001578 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1240471001579 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1240471001580 substrate binding site [chemical binding]; other site 1240471001581 active site 1240471001582 catalytic residues [active] 1240471001583 heterodimer interface [polypeptide binding]; other site 1240471001584 hypothetical protein; Provisional; Region: PRK02868 1240471001585 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1240471001586 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1240471001587 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1240471001588 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1240471001589 putative active site [active] 1240471001590 catalytic site [active] 1240471001591 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1240471001592 putative active site [active] 1240471001593 catalytic site [active] 1240471001594 thymidine kinase; Provisional; Region: PRK04296 1240471001595 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1240471001596 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1240471001597 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1240471001598 putative catalytic site [active] 1240471001599 putative phosphate binding site [ion binding]; other site 1240471001600 active site 1240471001601 metal binding site A [ion binding]; metal-binding site 1240471001602 DNA binding site [nucleotide binding] 1240471001603 putative AP binding site [nucleotide binding]; other site 1240471001604 putative metal binding site B [ion binding]; other site 1240471001605 protease 4; Provisional; Region: PRK10949 1240471001606 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1240471001607 tandem repeat interface [polypeptide binding]; other site 1240471001608 oligomer interface [polypeptide binding]; other site 1240471001609 active site residues [active] 1240471001610 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1240471001611 oligomer interface [polypeptide binding]; other site 1240471001612 tandem repeat interface [polypeptide binding]; other site 1240471001613 active site residues [active] 1240471001614 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1240471001615 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1240471001616 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1240471001617 disulfide bond formation protein B; Provisional; Region: PRK01749 1240471001618 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1240471001619 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1240471001620 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1240471001621 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1240471001622 Switch I; other site 1240471001623 Switch II; other site 1240471001624 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 1240471001625 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1240471001626 Glycoprotease family; Region: Peptidase_M22; pfam00814 1240471001627 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1240471001628 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1240471001629 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1240471001630 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1240471001631 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1240471001632 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1240471001633 Transporter associated domain; Region: CorC_HlyC; smart01091 1240471001634 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1240471001635 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1240471001636 active pocket/dimerization site; other site 1240471001637 active site 1240471001638 phosphorylation site [posttranslational modification] 1240471001639 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1240471001640 active site 1240471001641 phosphorylation site [posttranslational modification] 1240471001642 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1240471001643 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1240471001644 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1240471001645 DNA-binding site [nucleotide binding]; DNA binding site 1240471001646 RNA-binding motif; other site 1240471001647 heat shock protein HtpX; Provisional; Region: PRK05457 1240471001648 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1240471001649 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1240471001650 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1240471001651 pyruvate kinase; Provisional; Region: PRK05826 1240471001652 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1240471001653 domain interfaces; other site 1240471001654 active site 1240471001655 putative peptidase; Provisional; Region: PRK11649 1240471001656 Peptidase family M23; Region: Peptidase_M23; pfam01551 1240471001657 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1240471001658 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1240471001659 dimer interface [polypeptide binding]; other site 1240471001660 anticodon binding site; other site 1240471001661 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1240471001662 homodimer interface [polypeptide binding]; other site 1240471001663 motif 1; other site 1240471001664 active site 1240471001665 motif 2; other site 1240471001666 GAD domain; Region: GAD; pfam02938 1240471001667 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1240471001668 active site 1240471001669 motif 3; other site 1240471001670 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1240471001671 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1240471001672 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1240471001673 active site 1240471001674 HIGH motif; other site 1240471001675 KMSK motif region; other site 1240471001676 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1240471001677 tRNA binding surface [nucleotide binding]; other site 1240471001678 anticodon binding site; other site 1240471001679 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1240471001680 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1240471001681 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1240471001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1240471001683 putative substrate translocation pore; other site 1240471001684 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1240471001685 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1240471001686 putative active site [active] 1240471001687 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1240471001688 hypothetical protein; Provisional; Region: PRK05423 1240471001689 exonuclease I; Provisional; Region: sbcB; PRK11779 1240471001690 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1240471001691 active site 1240471001692 catalytic site [active] 1240471001693 substrate binding site [chemical binding]; other site 1240471001694 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1240471001695 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1240471001696 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1240471001697 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1240471001698 histidinol dehydrogenase; Region: hisD; TIGR00069 1240471001699 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1240471001700 NAD binding site [chemical binding]; other site 1240471001701 dimerization interface [polypeptide binding]; other site 1240471001702 product binding site; other site 1240471001703 substrate binding site [chemical binding]; other site 1240471001704 zinc binding site [ion binding]; other site 1240471001705 catalytic residues [active] 1240471001706 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1240471001707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1240471001708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1240471001709 homodimer interface [polypeptide binding]; other site 1240471001710 catalytic residue [active] 1240471001711 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1240471001712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1240471001713 active site 1240471001714 motif I; other site 1240471001715 motif II; other site 1240471001716 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1240471001717 putative active site pocket [active] 1240471001718 4-fold oligomerization interface [polypeptide binding]; other site 1240471001719 metal binding residues [ion binding]; metal-binding site 1240471001720 3-fold/trimer interface [polypeptide binding]; other site 1240471001721 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1240471001722 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1240471001723 putative active site [active] 1240471001724 oxyanion strand; other site 1240471001725 catalytic triad [active] 1240471001726 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1240471001727 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1240471001728 catalytic residues [active] 1240471001729 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1240471001730 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1240471001731 substrate binding site [chemical binding]; other site 1240471001732 glutamase interaction surface [polypeptide binding]; other site 1240471001733 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1240471001734 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1240471001735 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1240471001736 metal binding site [ion binding]; metal-binding site 1240471001737 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1240471001738 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1240471001739 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1240471001740 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1240471001741 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1240471001742 active site 1240471001743 HIGH motif; other site 1240471001744 KMSKS motif; other site 1240471001745 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1240471001746 tRNA binding surface [nucleotide binding]; other site 1240471001747 anticodon binding site; other site 1240471001748 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1240471001749 active site 1240471001750 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1240471001751 5S rRNA interface [nucleotide binding]; other site 1240471001752 CTC domain interface [polypeptide binding]; other site 1240471001753 L16 interface [polypeptide binding]; other site 1240471001754 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1240471001755 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1240471001756 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1240471001757 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1240471001758 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1240471001759 trimer interface [polypeptide binding]; other site 1240471001760 eyelet of channel; other site 1240471001761 DNA gyrase subunit A; Validated; Region: PRK05560 1240471001762 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1240471001763 CAP-like domain; other site 1240471001764 active site 1240471001765 primary dimer interface [polypeptide binding]; other site 1240471001766 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1240471001767 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1240471001768 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1240471001769 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1240471001770 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1240471001771 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1240471001772 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1240471001773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1240471001774 S-adenosylmethionine binding site [chemical binding]; other site 1240471001775 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1240471001776 ATP cone domain; Region: ATP-cone; pfam03477 1240471001777 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1240471001778 active site 1240471001779 dimer interface [polypeptide binding]; other site 1240471001780 catalytic residues [active] 1240471001781 effector binding site; other site 1240471001782 R2 peptide binding site; other site 1240471001783 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1240471001784 dimer interface [polypeptide binding]; other site 1240471001785 putative radical transfer pathway; other site 1240471001786 diiron center [ion binding]; other site 1240471001787 tyrosyl radical; other site 1240471001788 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1240471001789 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1240471001790 catalytic loop [active] 1240471001791 iron binding site [ion binding]; other site 1240471001792 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1240471001793 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1240471001794 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1240471001795 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1240471001796 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1240471001797 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1240471001798 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1240471001799 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1240471001800 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1240471001801 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1240471001802 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1240471001803 4Fe-4S binding domain; Region: Fer4; pfam00037 1240471001804 4Fe-4S binding domain; Region: Fer4; pfam00037 1240471001805 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1240471001806 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1240471001807 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1240471001808 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 1240471001809 catalytic loop [active] 1240471001810 iron binding site [ion binding]; other site 1240471001811 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1240471001812 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1240471001813 [4Fe-4S] binding site [ion binding]; other site 1240471001814 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1240471001815 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1240471001816 SLBB domain; Region: SLBB; pfam10531 1240471001817 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1240471001818 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1240471001819 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1240471001820 putative dimer interface [polypeptide binding]; other site 1240471001821 [2Fe-2S] cluster binding site [ion binding]; other site 1240471001822 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1240471001823 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1240471001824 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1240471001825 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1240471001826 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1240471001827 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1240471001828 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1240471001829 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1240471001830 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1240471001831 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1240471001832 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1240471001833 dimerization interface 3.5A [polypeptide binding]; other site 1240471001834 active site 1240471001835 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1240471001836 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1240471001837 ligand binding site [chemical binding]; other site 1240471001838 NAD binding site [chemical binding]; other site 1240471001839 catalytic site [active] 1240471001840 homodimer interface [polypeptide binding]; other site 1240471001841 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1240471001842 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1240471001843 dimer interface [polypeptide binding]; other site 1240471001844 active site 1240471001845 HemK family putative methylases; Region: hemK_fam; TIGR00536 1240471001846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1240471001847 S-adenosylmethionine binding site [chemical binding]; other site 1240471001848 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1240471001849 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1240471001850 Tetramer interface [polypeptide binding]; other site 1240471001851 active site 1240471001852 FMN-binding site [chemical binding]; other site 1240471001853 manganese transport protein MntH; Reviewed; Region: PRK00701 1240471001854 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1240471001855 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1240471001856 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1240471001857 Nucleoside recognition; Region: Gate; pfam07670 1240471001858 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1240471001859 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1240471001860 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1240471001861 active site 1240471001862 HIGH motif; other site 1240471001863 nucleotide binding site [chemical binding]; other site 1240471001864 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1240471001865 active site 1240471001866 KMSKS motif; other site 1240471001867 Ligase N family; Region: LIGANc; smart00532 1240471001868 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1240471001869 nucleotide binding pocket [chemical binding]; other site 1240471001870 K-X-D-G motif; other site 1240471001871 catalytic site [active] 1240471001872 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1240471001873 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1240471001874 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1240471001875 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1240471001876 dimer interface [polypeptide binding]; other site 1240471001877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1240471001878 catalytic residue [active] 1240471001879 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1240471001880 dimerization domain swap beta strand [polypeptide binding]; other site 1240471001881 regulatory protein interface [polypeptide binding]; other site 1240471001882 active site 1240471001883 regulatory phosphorylation site [posttranslational modification]; other site 1240471001884 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1240471001885 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1240471001886 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1240471001887 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1240471001888 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1240471001889 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1240471001890 Walker A/P-loop; other site 1240471001891 ATP binding site [chemical binding]; other site 1240471001892 Q-loop/lid; other site 1240471001893 ABC transporter signature motif; other site 1240471001894 Walker B; other site 1240471001895 D-loop; other site 1240471001896 H-loop/switch region; other site 1240471001897 sulfate transport protein; Provisional; Region: cysT; CHL00187 1240471001898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1240471001899 dimer interface [polypeptide binding]; other site 1240471001900 conserved gate region; other site 1240471001901 putative PBP binding loops; other site 1240471001902 ABC-ATPase subunit interface; other site 1240471001903 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1240471001904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1240471001905 dimer interface [polypeptide binding]; other site 1240471001906 conserved gate region; other site 1240471001907 putative PBP binding loops; other site 1240471001908 ABC-ATPase subunit interface; other site 1240471001909 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1240471001910 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1240471001911 Class I aldolases; Region: Aldolase_Class_I; cl17187 1240471001912 catalytic residue [active] 1240471001913 transketolase; Reviewed; Region: PRK12753 1240471001914 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1240471001915 TPP-binding site [chemical binding]; other site 1240471001916 dimer interface [polypeptide binding]; other site 1240471001917 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1240471001918 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1240471001919 PYR/PP interface [polypeptide binding]; other site 1240471001920 dimer interface [polypeptide binding]; other site 1240471001921 TPP binding site [chemical binding]; other site 1240471001922 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1240471001923 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1240471001924 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1240471001925 metal binding site [ion binding]; metal-binding site 1240471001926 dimer interface [polypeptide binding]; other site 1240471001927 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1240471001928 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1240471001929 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1240471001930 dimer interface [polypeptide binding]; other site 1240471001931 active site 1240471001932 catalytic residue [active] 1240471001933 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1240471001934 catalytic triad [active] 1240471001935 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1240471001936 active site 1240471001937 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1240471001938 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1240471001939 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1240471001940 UreF; Region: UreF; pfam01730 1240471001941 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1240471001942 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1240471001943 subunit interactions [polypeptide binding]; other site 1240471001944 active site 1240471001945 flap region; other site 1240471001946 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1240471001947 gamma-beta subunit interface [polypeptide binding]; other site 1240471001948 alpha-beta subunit interface [polypeptide binding]; other site 1240471001949 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1240471001950 alpha-gamma subunit interface [polypeptide binding]; other site 1240471001951 beta-gamma subunit interface [polypeptide binding]; other site 1240471001952 UreD urease accessory protein; Region: UreD; pfam01774 1240471001953 GMP synthase; Reviewed; Region: guaA; PRK00074 1240471001954 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1240471001955 AMP/PPi binding site [chemical binding]; other site 1240471001956 candidate oxyanion hole; other site 1240471001957 catalytic triad [active] 1240471001958 potential glutamine specificity residues [chemical binding]; other site 1240471001959 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1240471001960 ATP Binding subdomain [chemical binding]; other site 1240471001961 Ligand Binding sites [chemical binding]; other site 1240471001962 Dimerization subdomain; other site 1240471001963 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1240471001964 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1240471001965 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1240471001966 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1240471001967 active site 1240471001968 malate:quinone oxidoreductase; Validated; Region: PRK05257 1240471001969 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1240471001970 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 1240471001971 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1240471001972 G1 box; other site 1240471001973 GTP/Mg2+ binding site [chemical binding]; other site 1240471001974 Switch I region; other site 1240471001975 G2 box; other site 1240471001976 Switch II region; other site 1240471001977 G3 box; other site 1240471001978 G4 box; other site 1240471001979 G5 box; other site 1240471001980 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1240471001981 G1 box; other site 1240471001982 GTP/Mg2+ binding site [chemical binding]; other site 1240471001983 Switch I region; other site 1240471001984 G2 box; other site 1240471001985 G3 box; other site 1240471001986 Switch II region; other site 1240471001987 G4 box; other site 1240471001988 G5 box; other site 1240471001989 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1240471001990 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1240471001991 dimer interface [polypeptide binding]; other site 1240471001992 motif 1; other site 1240471001993 active site 1240471001994 motif 2; other site 1240471001995 motif 3; other site 1240471001996 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1240471001997 anticodon binding site; other site 1240471001998 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1240471001999 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1240471002000 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1240471002001 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1240471002002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1240471002003 FeS/SAM binding site; other site 1240471002004 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1240471002005 active site 1240471002006 multimer interface [polypeptide binding]; other site 1240471002007 cysteine desulfurase; Provisional; Region: PRK14012 1240471002008 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1240471002009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1240471002010 catalytic residue [active] 1240471002011 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1240471002012 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1240471002013 active site 1240471002014 dimerization interface [polypeptide binding]; other site 1240471002015 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1240471002016 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1240471002017 dimer interface [polypeptide binding]; other site 1240471002018 active site 1240471002019 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1240471002020 folate binding site [chemical binding]; other site 1240471002021 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1240471002022 nucleoside/Zn binding site; other site 1240471002023 dimer interface [polypeptide binding]; other site 1240471002024 catalytic motif [active] 1240471002025 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1240471002026 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1240471002027 active site 1240471002028 hydrophilic channel; other site 1240471002029 dimerization interface [polypeptide binding]; other site 1240471002030 catalytic residues [active] 1240471002031 active site lid [active] 1240471002032 ribonuclease III; Reviewed; Region: rnc; PRK00102 1240471002033 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1240471002034 dimerization interface [polypeptide binding]; other site 1240471002035 active site 1240471002036 metal binding site [ion binding]; metal-binding site 1240471002037 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1240471002038 dsRNA binding site [nucleotide binding]; other site 1240471002039 signal peptidase I; Provisional; Region: PRK10861 1240471002040 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1240471002041 Catalytic site [active] 1240471002042 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1240471002043 GTP-binding protein LepA; Provisional; Region: PRK05433 1240471002044 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1240471002045 G1 box; other site 1240471002046 putative GEF interaction site [polypeptide binding]; other site 1240471002047 GTP/Mg2+ binding site [chemical binding]; other site 1240471002048 Switch I region; other site 1240471002049 G2 box; other site 1240471002050 G3 box; other site 1240471002051 Switch II region; other site 1240471002052 G4 box; other site 1240471002053 G5 box; other site 1240471002054 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1240471002055 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1240471002056 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1240471002057 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1240471002058 ligand binding site [chemical binding]; other site 1240471002059 active site 1240471002060 UGI interface [polypeptide binding]; other site 1240471002061 catalytic site [active] 1240471002062 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1240471002063 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1240471002064 dimer interface [polypeptide binding]; other site 1240471002065 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1240471002066 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1240471002067 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1240471002068 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1240471002069 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1240471002070 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1240471002071 putative coenzyme Q binding site [chemical binding]; other site 1240471002072 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1240471002073 SmpB-tmRNA interface; other site 1240471002074 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1240471002075 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1240471002076 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1240471002077 domain interface [polypeptide binding]; other site 1240471002078 putative active site [active] 1240471002079 catalytic site [active] 1240471002080 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1240471002081 domain interface [polypeptide binding]; other site 1240471002082 putative active site [active] 1240471002083 catalytic site [active] 1240471002084 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1240471002085 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1240471002086 purine monophosphate binding site [chemical binding]; other site 1240471002087 dimer interface [polypeptide binding]; other site 1240471002088 putative catalytic residues [active] 1240471002089 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1240471002090 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1240471002091 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1240471002092 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1240471002093 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1240471002094 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1240471002095 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1240471002096 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1240471002097 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1240471002098 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1240471002099 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1240471002100 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1240471002101 DNA binding site [nucleotide binding] 1240471002102 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1240471002103 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1240471002104 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1240471002105 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1240471002106 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1240471002107 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1240471002108 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1240471002109 RPB3 interaction site [polypeptide binding]; other site 1240471002110 RPB1 interaction site [polypeptide binding]; other site 1240471002111 RPB11 interaction site [polypeptide binding]; other site 1240471002112 RPB10 interaction site [polypeptide binding]; other site 1240471002113 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1240471002114 core dimer interface [polypeptide binding]; other site 1240471002115 peripheral dimer interface [polypeptide binding]; other site 1240471002116 L10 interface [polypeptide binding]; other site 1240471002117 L11 interface [polypeptide binding]; other site 1240471002118 putative EF-Tu interaction site [polypeptide binding]; other site 1240471002119 putative EF-G interaction site [polypeptide binding]; other site 1240471002120 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1240471002121 23S rRNA interface [nucleotide binding]; other site 1240471002122 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1240471002123 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1240471002124 mRNA/rRNA interface [nucleotide binding]; other site 1240471002125 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1240471002126 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1240471002127 23S rRNA interface [nucleotide binding]; other site 1240471002128 L7/L12 interface [polypeptide binding]; other site 1240471002129 putative thiostrepton binding site; other site 1240471002130 L25 interface [polypeptide binding]; other site 1240471002131 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1240471002132 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1240471002133 putative homodimer interface [polypeptide binding]; other site 1240471002134 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1240471002135 heterodimer interface [polypeptide binding]; other site 1240471002136 homodimer interface [polypeptide binding]; other site 1240471002137 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1240471002138 elongation factor Tu; Reviewed; Region: PRK00049 1240471002139 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1240471002140 G1 box; other site 1240471002141 GEF interaction site [polypeptide binding]; other site 1240471002142 GTP/Mg2+ binding site [chemical binding]; other site 1240471002143 Switch I region; other site 1240471002144 G2 box; other site 1240471002145 G3 box; other site 1240471002146 Switch II region; other site 1240471002147 G4 box; other site 1240471002148 G5 box; other site 1240471002149 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1240471002150 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1240471002151 Antibiotic Binding Site [chemical binding]; other site 1240471002152 elongation factor G; Reviewed; Region: PRK00007 1240471002153 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1240471002154 G1 box; other site 1240471002155 putative GEF interaction site [polypeptide binding]; other site 1240471002156 GTP/Mg2+ binding site [chemical binding]; other site 1240471002157 Switch I region; other site 1240471002158 G2 box; other site 1240471002159 G3 box; other site 1240471002160 Switch II region; other site 1240471002161 G4 box; other site 1240471002162 G5 box; other site 1240471002163 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1240471002164 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1240471002165 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1240471002166 30S ribosomal protein S7; Validated; Region: PRK05302 1240471002167 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1240471002168 S17 interaction site [polypeptide binding]; other site 1240471002169 S8 interaction site; other site 1240471002170 16S rRNA interaction site [nucleotide binding]; other site 1240471002171 streptomycin interaction site [chemical binding]; other site 1240471002172 23S rRNA interaction site [nucleotide binding]; other site 1240471002173 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1240471002174 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1240471002175 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1240471002176 glutamine binding [chemical binding]; other site 1240471002177 catalytic triad [active] 1240471002178 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1240471002179 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1240471002180 active site 1240471002181 HIGH motif; other site 1240471002182 dimer interface [polypeptide binding]; other site 1240471002183 KMSKS motif; other site 1240471002184 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1240471002185 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1240471002186 substrate binding site [chemical binding]; other site 1240471002187 hexamer interface [polypeptide binding]; other site 1240471002188 metal binding site [ion binding]; metal-binding site 1240471002189 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1240471002190 active site 1240471002191 dimer interface [polypeptide binding]; other site 1240471002192 metal binding site [ion binding]; metal-binding site 1240471002193 shikimate kinase; Reviewed; Region: aroK; PRK00131 1240471002194 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1240471002195 ADP binding site [chemical binding]; other site 1240471002196 magnesium binding site [ion binding]; other site 1240471002197 putative shikimate binding site; other site 1240471002198 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1240471002199 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1240471002200 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1240471002201 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1240471002202 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1240471002203 putative antibiotic transporter; Provisional; Region: PRK10739 1240471002204 putative hydrolase; Provisional; Region: PRK10976 1240471002205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1240471002206 active site 1240471002207 motif I; other site 1240471002208 motif II; other site 1240471002209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1240471002210 motif II; other site 1240471002211 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1240471002212 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1240471002213 Cl binding site [ion binding]; other site 1240471002214 oligomer interface [polypeptide binding]; other site 1240471002215 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1240471002216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1240471002217 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1240471002218 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1240471002219 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1240471002220 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1240471002221 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1240471002222 domain interfaces; other site 1240471002223 active site 1240471002224 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1240471002225 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1240471002226 active site 1240471002227 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1240471002228 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1240471002229 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1240471002230 RNA binding site [nucleotide binding]; other site 1240471002231 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1240471002232 multimer interface [polypeptide binding]; other site 1240471002233 Walker A motif; other site 1240471002234 ATP binding site [chemical binding]; other site 1240471002235 Walker B motif; other site 1240471002236 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1240471002237 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1240471002238 catalytic residues [active] 1240471002239 ketol-acid reductoisomerase; Validated; Region: PRK05225 1240471002240 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1240471002241 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1240471002242 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1240471002243 threonine dehydratase; Reviewed; Region: PRK09224 1240471002244 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1240471002245 tetramer interface [polypeptide binding]; other site 1240471002246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1240471002247 catalytic residue [active] 1240471002248 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1240471002249 putative Ile/Val binding site [chemical binding]; other site 1240471002250 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1240471002251 putative Ile/Val binding site [chemical binding]; other site 1240471002252 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1240471002253 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1240471002254 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1240471002255 homodimer interface [polypeptide binding]; other site 1240471002256 substrate-cofactor binding pocket; other site 1240471002257 catalytic residue [active] 1240471002258 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1240471002259 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1240471002260 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1240471002261 PYR/PP interface [polypeptide binding]; other site 1240471002262 dimer interface [polypeptide binding]; other site 1240471002263 TPP binding site [chemical binding]; other site 1240471002264 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1240471002265 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1240471002266 TPP-binding site [chemical binding]; other site 1240471002267 dimer interface [polypeptide binding]; other site 1240471002268 glutamate racemase; Provisional; Region: PRK00865 1240471002269 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1240471002270 FAD binding site [chemical binding]; other site 1240471002271 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 1240471002272 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1240471002273 homodimer interface [polypeptide binding]; other site 1240471002274 substrate-cofactor binding pocket; other site 1240471002275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1240471002276 catalytic residue [active] 1240471002277 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1240471002278 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1240471002279 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1240471002280 FAD binding pocket [chemical binding]; other site 1240471002281 FAD binding motif [chemical binding]; other site 1240471002282 phosphate binding motif [ion binding]; other site 1240471002283 beta-alpha-beta structure motif; other site 1240471002284 NAD binding pocket [chemical binding]; other site 1240471002285 triosephosphate isomerase; Provisional; Region: PRK14567 1240471002286 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1240471002287 substrate binding site [chemical binding]; other site 1240471002288 dimer interface [polypeptide binding]; other site 1240471002289 catalytic triad [active] 1240471002290 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1240471002291 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1240471002292 active site 1240471002293 ADP/pyrophosphate binding site [chemical binding]; other site 1240471002294 dimerization interface [polypeptide binding]; other site 1240471002295 allosteric effector site; other site 1240471002296 fructose-1,6-bisphosphate binding site; other site 1240471002297 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 1240471002298 serine O-acetyltransferase; Region: cysE; TIGR01172 1240471002299 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1240471002300 trimer interface [polypeptide binding]; other site 1240471002301 active site 1240471002302 substrate binding site [chemical binding]; other site 1240471002303 CoA binding site [chemical binding]; other site 1240471002304 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1240471002305 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1240471002306 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1240471002307 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1240471002308 SecA binding site; other site 1240471002309 Preprotein binding site; other site 1240471002310 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1240471002311 GSH binding site [chemical binding]; other site 1240471002312 catalytic residues [active] 1240471002313 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1240471002314 active site residue [active] 1240471002315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1240471002316 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1240471002317 NAD(P) binding site [chemical binding]; other site 1240471002318 active site 1240471002319 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1240471002320 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1240471002321 putative active site [active] 1240471002322 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1240471002323 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1240471002324 putative active site [active] 1240471002325 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1240471002326 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1240471002327 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1240471002328 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1240471002329 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1240471002330 active site 1240471002331 (T/H)XGH motif; other site 1240471002332 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1240471002333 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1240471002334 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1240471002335 Flavoprotein; Region: Flavoprotein; pfam02441 1240471002336 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1240471002337 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1240471002338 trimer interface [polypeptide binding]; other site 1240471002339 active site 1240471002340 hypothetical protein; Provisional; Region: PRK11820 1240471002341 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1240471002342 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1240471002343 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1240471002344 MarR family; Region: MarR; pfam01047 1240471002345 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1240471002346 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1240471002347 catalytic site [active] 1240471002348 G-X2-G-X-G-K; other site 1240471002349 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1240471002350 glutamine synthetase; Provisional; Region: glnA; PRK09469 1240471002351 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1240471002352 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1240471002353 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1240471002354 G1 box; other site 1240471002355 GTP/Mg2+ binding site [chemical binding]; other site 1240471002356 Switch I region; other site 1240471002357 G2 box; other site 1240471002358 G3 box; other site 1240471002359 Switch II region; other site 1240471002360 G4 box; other site 1240471002361 G5 box; other site 1240471002362 DNA polymerase I; Provisional; Region: PRK05755 1240471002363 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1240471002364 active site 1240471002365 metal binding site 1 [ion binding]; metal-binding site 1240471002366 putative 5' ssDNA interaction site; other site 1240471002367 metal binding site 3; metal-binding site 1240471002368 metal binding site 2 [ion binding]; metal-binding site 1240471002369 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1240471002370 putative DNA binding site [nucleotide binding]; other site 1240471002371 putative metal binding site [ion binding]; other site 1240471002372 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1240471002373 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1240471002374 active site 1240471002375 DNA binding site [nucleotide binding] 1240471002376 catalytic site [active] 1240471002377 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1240471002378 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1240471002379 catalytic residues [active] 1240471002380 hinge region; other site 1240471002381 alpha helical domain; other site 1240471002382 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1240471002383 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1240471002384 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1240471002385 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1240471002386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1240471002387 S-adenosylmethionine binding site [chemical binding]; other site 1240471002388 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1240471002389 RmuC family; Region: RmuC; pfam02646 1240471002390 uridine phosphorylase; Provisional; Region: PRK11178 1240471002391 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1240471002392 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1240471002393 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1240471002394 THF binding site; other site 1240471002395 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1240471002396 substrate binding site [chemical binding]; other site 1240471002397 THF binding site; other site 1240471002398 zinc-binding site [ion binding]; other site 1240471002399 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1240471002400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1240471002401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1240471002402 DNA binding residues [nucleotide binding] 1240471002403 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1240471002404 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1240471002405 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1240471002406 P loop; other site 1240471002407 GTP binding site [chemical binding]; other site 1240471002408 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1240471002409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1240471002410 S-adenosylmethionine binding site [chemical binding]; other site 1240471002411 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1240471002412 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1240471002413 active site 1240471002414 dimer interface [polypeptide binding]; other site 1240471002415 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1240471002416 dimer interface [polypeptide binding]; other site 1240471002417 active site 1240471002418 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1240471002419 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1240471002420 proposed active site lysine [active] 1240471002421 conserved cys residue [active]