-- dump date 20140619_022537 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 291272000001 SEQ_END SEQ_END NC_007292.1 791654 791654 DR NC_007292.1; contig end 791654..791654 Candidatus Blochmannia pennsylvanicus str. BPEN YP_277523.1 CDS gidA NC_007292.1 1 1899 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 1..1899 Candidatus Blochmannia pennsylvanicus str. BPEN 3562782 YP_277524.1 CDS atpB NC_007292.1 2617 3426 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 2617..3426 Candidatus Blochmannia pennsylvanicus str. BPEN 3562783 YP_277525.1 CDS atpE NC_007292.1 3466 3705 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 3466..3705 Candidatus Blochmannia pennsylvanicus str. BPEN 3562784 YP_277526.1 CDS atpF NC_007292.1 3765 4247 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 3765..4247 Candidatus Blochmannia pennsylvanicus str. BPEN 3562785 YP_277527.1 CDS atpH NC_007292.1 4248 4793 D ortholog to Escherichia coli bnum: b3735; MultiFun: Cell structure 6.1; Metabolism 1.3.8; Transport 4.3.A.2, 4.S.82; ATP synthase F1 subunit delta 4248..4793 Candidatus Blochmannia pennsylvanicus str. BPEN 3562786 YP_277528.1 CDS atpA NC_007292.1 4831 6372 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 4831..6372 Candidatus Blochmannia pennsylvanicus str. BPEN 3562621 YP_277529.1 CDS atpG NC_007292.1 6405 7271 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 6405..7271 Candidatus Blochmannia pennsylvanicus str. BPEN 3562622 YP_277530.1 CDS atpD NC_007292.1 7302 8690 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 7302..8690 Candidatus Blochmannia pennsylvanicus str. BPEN 3562623 YP_277531.1 CDS atpC NC_007292.1 8728 9162 D ortholog to Escherichia coli bnum: b3731; MultiFun: Cell structure 6.1; Metabolism 1.3.8; Transport 4.3.A.2, 4.S.82; ATP synthase F1 subunit epsilon 8728..9162 Candidatus Blochmannia pennsylvanicus str. BPEN 3562624 YP_277532.1 CDS glmU NC_007292.1 9294 10682 D bifunctional; ortholog to Escherichia coli bnum: b3730; MultiFun: Cell structure 6.1, 6.2, 6.3; Metabolism 1.1.4, 1.6.3.1, 1.6.4, 1.6.7, 1.7.10, 1.7.12; glucosamine-1-phosphate acetyl transferase; N-acetyl glucosamine-1-phosphate uridyltransferase 9294..10682 Candidatus Blochmannia pennsylvanicus str. BPEN 3562625 YP_277533.1 CDS trmE NC_007292.1 10913 12325 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(10913..12325) Candidatus Blochmannia pennsylvanicus str. BPEN 3562626 YP_277534.1 CDS yidCD NC_007292.1 12400 14316 R ortholog to Escherichia coli bnum: b3705; involved in protein translocation and folding, substrates includes ATP synthase, SecYEG, LacY, 5' fusion with uncharacterized protein YidD; MultiFun: Cell structure 6.1; Transport 4.2.A.9, 4.S.preprotein; hypothetical protein complement(12400..14316) Candidatus Blochmannia pennsylvanicus str. BPEN 3562627 YP_277535.1 CDS rnpA NC_007292.1 14295 14642 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(14295..14642) Candidatus Blochmannia pennsylvanicus str. BPEN 3562628 YP_277536.1 CDS rmpH NC_007292.1 14666 14818 R ortholog to Escherichia coli bnum: b3703; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L34 complement(14666..14818) Candidatus Blochmannia pennsylvanicus str. BPEN 3562629 YP_277537.1 CDS dnaN NC_007292.1 15161 16264 D ortholog to Escherichia coli bnum: b3701; MultiFun: Information transfer 2.1.1; DNA polymerase III, beta-subunit 15161..16264 Candidatus Blochmannia pennsylvanicus str. BPEN 3562630 YP_277538.1 CDS gyrB NC_007292.1 16575 18989 D type II topoisomerase; ortholog to Escherichia coli bnum: b3699; MultiFun: Information transfer 2.1.1, 2.2.2; Regulation 3.1.1.1; DNA gyrase subunit B 16575..18989 Candidatus Blochmannia pennsylvanicus str. BPEN 3562631 YP_277539.1 CDS ibpA NC_007292.1 19201 19611 D ortholog to Escherichia coli bnum: b3687; MultiFun: Cell processes 5.5.2, 5.5.6; heat shock protein A 19201..19611 Candidatus Blochmannia pennsylvanicus str. BPEN 3562632 YP_277540.1 CDS BPEN_018 NC_007292.1 19765 20772 R transmembrane protein complement(19765..20772) Candidatus Blochmannia pennsylvanicus str. BPEN 3563199 YP_277541.1 CDS glyQ NC_007292.1 21218 22132 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 21218..22132 Candidatus Blochmannia pennsylvanicus str. BPEN 3563200 YP_277542.1 CDS glyS NC_007292.1 22156 24243 D ortholog to Escherichia coli bnum: b3559; MultiFun: Information transfer 2.3.1; glycine-tRNA synthetase, beta subunit 22156..24243 Candidatus Blochmannia pennsylvanicus str. BPEN 3563201 YP_277543.1 CDS sodA NC_007292.1 24354 24971 R ortholog to Escherichia coli bnum: b3908; MultiFun: Cell processes 5.5.6, 5.6.2; superoxide dismutase (Mn) complement(24354..24971) Candidatus Blochmannia pennsylvanicus str. BPEN 3563202 YP_277544.1 CDS prlC NC_007292.1 25566 27638 D ortholog to Escherichia coli bnum: b3498; MultiFun: Metabolism 1.2.3; oligopeptidase A 25566..27638 Candidatus Blochmannia pennsylvanicus str. BPEN 3563204 YP_277545.1 CDS pitA NC_007292.1 28064 29686 R ortholog to Escherichia coli bnum: b3493; MultiFun: Cell structure 6.1; Metabolism 1.8.1; Transport 4.2.A.20, 4.S.155; inorganic phosphate transporter complement(28064..29686) Candidatus Blochmannia pennsylvanicus str. BPEN 3563205 YP_277546.1 CDS ubiA NC_007292.1 30037 30909 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 30037..30909 Candidatus Blochmannia pennsylvanicus str. BPEN 3563206 YP_277547.1 CDS zur NC_007292.1 31195 31668 R ortholog to Escherichia coli bnum: b4046; MultiFun: Information transfer 2.2.2; Regulation 3.1.1, 3.1.2.3, 3.3.1; Zn transport system transcriptional repressor complement(31195..31668) Candidatus Blochmannia pennsylvanicus str. BPEN 3563207 YP_277548.1 CDS dnaB NC_007292.1 32173 33588 D ortholog to Escherichia coli bnum: b4052; MultiFun: Information transfer 2.1.1; replicative DNA helicase 32173..33588 Candidatus Blochmannia pennsylvanicus str. BPEN 3563208 YP_277549.1 CDS ssb NC_007292.1 34030 34521 D ortholog to Escherichia coli bnum: b4059; MultiFun: Cell processes 5.8; Information transfer 2.1.3; ssDNA-binding protein controls activity of RecBCD nuclease 34030..34521 Candidatus Blochmannia pennsylvanicus str. BPEN 3562913 YP_277550.1 CDS yjcE NC_007292.1 35067 36710 D ortholog to Escherichia coli bnum: b4065; MultiFun: Cell structure 6.1; Transport 4.2.A.36, 4.S.136; CPA1 family Na+/H+ antiporter 35067..36710 Candidatus Blochmannia pennsylvanicus str. BPEN 3562914 YP_277551.1 CDS gltP NC_007292.1 37404 38693 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 37404..38693 Candidatus Blochmannia pennsylvanicus str. BPEN 3562915 YP_277552.1 CDS yjgF NC_007292.1 39009 39410 R ortholog to Escherichia coli bnum: b4243; translation initiation inhibitor complement(39009..39410) Candidatus Blochmannia pennsylvanicus str. BPEN 3562916 YP_277553.1 CDS argI NC_007292.1 39495 40520 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I complement(39495..40520) Candidatus Blochmannia pennsylvanicus str. BPEN 3562917 YP_277554.1 CDS valS NC_007292.1 40789 43662 R ortholog to Escherichia coli bnum: b4258; MultiFun: Information transfer 2.3.1; valine tRNA synthetase complement(40789..43662) Candidatus Blochmannia pennsylvanicus str. BPEN 3562918 YP_277555.1 CDS holC NC_007292.1 43659 44111 R ortholog to Escherichia coli bnum: b4259; MultiFun: Information transfer 2.1.1; DNA polymerase III subunit chi complement(43659..44111) Candidatus Blochmannia pennsylvanicus str. BPEN 3563195 YP_277556.1 CDS pepA NC_007292.1 44226 45737 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(44226..45737) Candidatus Blochmannia pennsylvanicus str. BPEN 3563196 YP_277557.1 CDS yjgP NC_007292.1 45983 47104 D ortholog to Escherichia coli bnum: b4261; MultiFun: Cell structure 6.1; Transport 4; transmembrane protein, transport 45983..47104 Candidatus Blochmannia pennsylvanicus str. BPEN 3562939 YP_277558.1 CDS yjgQ NC_007292.1 47110 48183 D ortholog to Escherichia coli bnum: b4262; MultiFun: Cell structure 6.1; transmembrane protein, transport 47110..48183 Candidatus Blochmannia pennsylvanicus str. BPEN 3562667 YP_277559.1 CDS yidZ NC_007292.1 48217 49116 R ortholog to Escherichia coli bnum: b3711; MultiFun: Information transfer 2.2.2; Regulation 3.1.2.2, 3.1.2.3; transcriptional regulator complement(48217..49116) Candidatus Blochmannia pennsylvanicus str. BPEN 3562668 YP_277560.1 CDS BPEN_040 NC_007292.1 49993 50130 D hypothetical protein 49993..50130 Candidatus Blochmannia pennsylvanicus str. BPEN 3562887 YP_277561.1 CDS znuC NC_007292.1 50149 50796 D ortholog to Escherichia coli bnum: b1858; MultiFun: Metabolism 1.5.3.12; Transport 4.3.A.1.a, 4.S.191; high-affinity Zn ABC transporter ATP-binding protein 50149..50796 Candidatus Blochmannia pennsylvanicus str. BPEN 3562888 YP_277562.1 CDS znuB NC_007292.1 50887 51747 D ortholog to Escherichia coli bnum: b1859; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.191; high-affinity Zn ABC transporter membrane protein 50887..51747 Candidatus Blochmannia pennsylvanicus str. BPEN 3562889 YP_277563.1 CDS yhbG NC_007292.1 52506 53231 R ortholog to Escherichia coli bnum: b3201; MultiFun: Transport 4.3.A.1.a; ABC transporter ATP-binding protein complement(52506..53231) Candidatus Blochmannia pennsylvanicus str. BPEN 3562890 YP_277564.1 CDS yhbN NC_007292.1 53277 53786 R ortholog to Escherichia coli bnum: b3200; MultiFun: Transport 4.3.A.1.p; ABC transporter periplasmic substrate-binding protein complement(53277..53786) Candidatus Blochmannia pennsylvanicus str. BPEN 3562891 YP_277565.1 CDS yrbK NC_007292.1 53764 54381 R ortholog to Escherichia coli bnum: b3199; hypothetical protein complement(53764..54381) Candidatus Blochmannia pennsylvanicus str. BPEN 3562892 YP_277566.1 CDS yrbA NC_007292.1 56953 57222 D ortholog to Escherichia coli bnum: b3190; MultiFun: Regulation 3.1.2; BolA family transcriptional regulator 56953..57222 Candidatus Blochmannia pennsylvanicus str. BPEN 3562893 YP_277567.1 CDS murA NC_007292.1 57272 58537 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 57272..58537 Candidatus Blochmannia pennsylvanicus str. BPEN 3562894 YP_277568.1 CDS degQ NC_007292.1 58826 60199 R ortholog to Escherichia coli bnum: b3234; MultiFun: Metabolism 1.2.3; serine protease complement(58826..60199) Candidatus Blochmannia pennsylvanicus str. BPEN 3562895 YP_277569.1 CDS yhcB NC_007292.1 60426 60824 R ortholog to Escherichia coli bnum: b3233; hypothetical protein complement(60426..60824) Candidatus Blochmannia pennsylvanicus str. BPEN 3562896 YP_277570.1 CDS rplM NC_007292.1 61354 61788 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 61354..61788 Candidatus Blochmannia pennsylvanicus str. BPEN 3563001 YP_277571.1 CDS rpsI NC_007292.1 61816 62214 D ortholog to Escherichia coli bnum: b3230; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S9 61816..62214 Candidatus Blochmannia pennsylvanicus str. BPEN 3563002 YP_277572.1 CDS yraP NC_007292.1 63709 64299 R ortholog to Escherichia coli bnum: b3150; MultiFun: Transport 4.9.B; hypothetical protein complement(63709..64299) Candidatus Blochmannia pennsylvanicus str. BPEN 3563003 YP_277573.1 CDS yraL NC_007292.1 64871 65764 D ortholog to Escherichia coli bnum: b3146; hypothetical protein 64871..65764 Candidatus Blochmannia pennsylvanicus str. BPEN 3563004 YP_277574.1 CDS yqjA NC_007292.1 66815 67381 D ortholog to Escherichia coli bnum: b3095; MultiFun: Cell structure 6.1; hypothetical protein 66815..67381 Candidatus Blochmannia pennsylvanicus str. BPEN 3563006 YP_277575.1 CDS rpoD NC_007292.1 67947 69782 R ortholog to Escherichia coli bnum: b3067; MultiFun: Information transfer 2.2.2; Regulation 3.1.2.1, 3.3.3; RNA polymerase sigma-70 factor complement(67947..69782) Candidatus Blochmannia pennsylvanicus str. BPEN 3563008 YP_277576.1 CDS dnaG NC_007292.1 69956 71701 R ortholog to Escherichia coli bnum: b3066; MultiFun: Information transfer 2.1.1; DNA primase complement(69956..71701) Candidatus Blochmannia pennsylvanicus str. BPEN 3563009 YP_277577.1 CDS rpsU NC_007292.1 71861 72076 R ortholog to Escherichia coli bnum: b3065; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S21 complement(71861..72076) Candidatus Blochmannia pennsylvanicus str. BPEN 3563010 YP_277578.1 CDS gcp NC_007292.1 72239 73264 D ortholog to Escherichia coli bnum: b3064; MultiFun: Metabolism 1.2.3; O-sialoglycoprotein endopeptidase 72239..73264 Candidatus Blochmannia pennsylvanicus str. BPEN 3562953 YP_277579.1 CDS ygiH NC_007292.1 73289 73876 R ortholog to Escherichia coli bnum: b3059; MultiFun: Cell structure 6.1; hypothetical protein complement(73289..73876) Candidatus Blochmannia pennsylvanicus str. BPEN 3562954 YP_277580.1 CDS folB NC_007292.1 73996 74379 D ortholog to Escherichia coli bnum: b3058; MultiFun: Metabolism 1.5.3.2; dihydroneopterin aldolase, also has dihydroneopterin triphosphate 73996..74379 Candidatus Blochmannia pennsylvanicus str. BPEN 3563146 YP_277581.1 CDS bacA NC_007292.1 74475 75359 D ortholog to Escherichia coli bnum: b3057; MultiFun: Cell processes 5.6.4; Cell structure 6.1; bacitracin resistance protein 74475..75359 Candidatus Blochmannia pennsylvanicus str. BPEN 3563147 YP_277582.1 CDS cca NC_007292.1 75623 76849 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(75623..76849) Candidatus Blochmannia pennsylvanicus str. BPEN 3563148 YP_277583.1 CDS hldE NC_007292.1 77297 78730 D catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 77297..78730 Candidatus Blochmannia pennsylvanicus str. BPEN 3563149 YP_277584.1 CDS ribB NC_007292.1 79574 80218 D DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 79574..80218 Candidatus Blochmannia pennsylvanicus str. BPEN 3563151 YP_277585.1 CDS plsC NC_007292.1 80554 81291 D ortholog to Escherichia coli bnum: b3018; MultiFun: Cell structure 6.1; Metabolism 1.5.4; 1-acylglycerol-3-phosphate O-acyltransferase 80554..81291 Candidatus Blochmannia pennsylvanicus str. BPEN 3563152 YP_277586.1 CDS metC NC_007292.1 81475 82662 R ortholog to Escherichia coli bnum: b3008; MultiFun: Metabolism 1.5.1.9; beta-cystathionase complement(81475..82662) Candidatus Blochmannia pennsylvanicus str. BPEN 3563153 YP_277587.1 CDS cutA NC_007292.1 84670 84987 R ortholog to Escherichia coli bnum: b4137; MultiFun: Cell processes 5.5.6; Metabolism 1.6.15.1; divalent cation tolerance protein complement(84670..84987) Candidatus Blochmannia pennsylvanicus str. BPEN 3563155 YP_277588.1 CDS groES NC_007292.1 85399 85692 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 85399..85692 Candidatus Blochmannia pennsylvanicus str. BPEN 3563156 YP_277589.1 CDS groEL NC_007292.1 85742 87379 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 85742..87379 Candidatus Blochmannia pennsylvanicus str. BPEN 3563043 YP_277590.1 CDS efp NC_007292.1 87508 88074 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 87508..88074 Candidatus Blochmannia pennsylvanicus str. BPEN 3563044 YP_277591.1 CDS yjeP NC_007292.1 88088 91480 R ortholog to Escherichia coli bnum: b4159; MultiFun: Transport 4.9.B; hypothetical protein complement(88088..91480) Candidatus Blochmannia pennsylvanicus str. BPEN 3563045 YP_277592.1 CDS psd NC_007292.1 91537 92424 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(91537..92424) Candidatus Blochmannia pennsylvanicus str. BPEN 3563046 YP_277593.1 CDS orn NC_007292.1 93133 93696 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 93133..93696 Candidatus Blochmannia pennsylvanicus str. BPEN 3563047 YP_277594.1 CDS yjeE NC_007292.1 94487 94975 D ortholog to Escherichia coli bnum: b4168; nucleoside triP hydrolase domain-containing protein 94487..94975 Candidatus Blochmannia pennsylvanicus str. BPEN 3563049 YP_277595.1 CDS amiB NC_007292.1 94972 96243 D ortholog to Escherichia coli bnum: b4169; MultiFun: Cell processes 5.1; Cell structure 6.2; Metabolism 1.6.7; N-acetylmuramoyl-L-alanine amidase 94972..96243 Candidatus Blochmannia pennsylvanicus str. BPEN 3563050 YP_277596.1 CDS miaA NC_007292.1 96505 97419 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 96505..97419 Candidatus Blochmannia pennsylvanicus str. BPEN 3563051 YP_277597.1 CDS hfq NC_007292.1 97510 97755 D ortholog to Escherichia coli bnum: b4172; bacteriophage Q beta replication; RNA binding; mRNA degradation; stimulates poly(A) polymerase I; MultiFun: Information transfer 2.3.7; Regulation 3.1.3.1, 3.3.4; host factor I 97510..97755 Candidatus Blochmannia pennsylvanicus str. BPEN 3563052 YP_277598.1 CDS hflX NC_007292.1 97918 99204 D GTP binding subunit of protease specific for phage lambda cII repressor; ortholog to Escherichia coli bnum: b4173; MultiFun: Metabolism 1.2.3; hypothetical protein 97918..99204 Candidatus Blochmannia pennsylvanicus str. BPEN 3563187 YP_277599.1 CDS hflK NC_007292.1 99260 100555 D with HflC, part of modulator for protease specific for HflB (FtsH) phage lambda cII repressor; ortholog to Escherichia coli bnum: b4174; MultiFun: Metabolism 1.2.3; HflK protein 99260..100555 Candidatus Blochmannia pennsylvanicus str. BPEN 3563188 YP_277600.1 CDS hflC NC_007292.1 100556 101584 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 100556..101584 Candidatus Blochmannia pennsylvanicus str. BPEN 3563189 YP_277601.1 CDS purA NC_007292.1 101746 103044 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 101746..103044 Candidatus Blochmannia pennsylvanicus str. BPEN 3563190 YP_277602.1 CDS rlmB NC_007292.1 103280 104023 D ortholog to Escherichia coli bnum: b4180; MultiFun: Information transfer 2.2.3; tRNA/rRNA methyltransferase 103280..104023 Candidatus Blochmannia pennsylvanicus str. BPEN 3563191 YP_277603.1 CDS rpsF NC_007292.1 104194 104547 D ortholog to Escherichia coli bnum: b4200; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S6 104194..104547 Candidatus Blochmannia pennsylvanicus str. BPEN 3563192 YP_277604.1 CDS rpsR NC_007292.1 104772 105011 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 104772..105011 Candidatus Blochmannia pennsylvanicus str. BPEN 3563193 YP_277605.1 CDS rplI NC_007292.1 105066 105527 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 105066..105527 Candidatus Blochmannia pennsylvanicus str. BPEN 3563194 YP_277606.1 CDS cysQ NC_007292.1 105822 106577 D acts on 3'-phosphoadenosine-5'-phosphosulfate with sugar phosphatase domain; ortholog to Escherichia coli bnum: b4214; MultiFun: Metabolism 1.8.2; protein CysQ 105822..106577 Candidatus Blochmannia pennsylvanicus str. BPEN 3562900 YP_277607.1 CDS ytfM NC_007292.1 106992 108754 D ortholog to E. coli bnum: b4220; in-frame premature UAG termination codon is located within the ytfM sequence, and a -1 frameshift would be required for synthesis of ytfM; RNA polymerase or ribosomal slippage; possible young pseudogene; MultiFun: Cell structure 6.1; outer membrane protein join(106992..107185,107185..108754) Candidatus Blochmannia pennsylvanicus str. BPEN 3562901 YP_277608.1 CDS ytfN NC_007292.1 108751 112590 D ortholog to Escherichia coli bnum: b4221; hypothetical protein 108751..112590 Candidatus Blochmannia pennsylvanicus str. BPEN 3562902 YP_277609.1 CDS ppa NC_007292.1 112666 113199 R PPase; ortholog to Escherichia coli bnum: b4226; MultiFun: Metabolism 1.7.1, 1.8.1; pyrophosphate phospho-hydrolase; inorganic pyrophosphatase complement(112666..113199) Candidatus Blochmannia pennsylvanicus str. BPEN 3563175 YP_277610.1 CDS ispB NC_007292.1 113396 114367 R ortholog to Escherichia coli bnum: b3187; MultiFun: Metabolism 1.5.3.19; octaprenyl-diphosphate synthase complement(113396..114367) Candidatus Blochmannia pennsylvanicus str. BPEN 3563176 YP_277611.1 CDS rplU NC_007292.1 114559 114876 D ortholog to Escherichia coli bnum: b3186; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L21 114559..114876 Candidatus Blochmannia pennsylvanicus str. BPEN 3563177 YP_277612.1 CDS rpmA NC_007292.1 114922 115176 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 114922..115176 Candidatus Blochmannia pennsylvanicus str. BPEN 3563178 YP_277613.1 CDS obgE NC_007292.1 115536 116558 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 115536..116558 Candidatus Blochmannia pennsylvanicus str. BPEN 3563179 YP_277614.1 CDS greA NC_007292.1 116889 117365 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 116889..117365 Candidatus Blochmannia pennsylvanicus str. BPEN 3563180 YP_277615.1 CDS rrmJ NC_007292.1 117742 118368 D ortholog to Escherichia coli bnum: b3179; MultiFun: Cell processes 5.1; ribosomal RNA large subunit (23S) methyltransferase J 117742..118368 Candidatus Blochmannia pennsylvanicus str. BPEN 3563181 YP_277616.1 CDS hflB NC_007292.1 118442 120370 D cell division protein; ATP-dependent zinc-metallo protease; ortholog to Escherichia coli bnum: b3178; MultiFun: Cell structure 6.1; Metabolism 1.2.3; hypothetical protein 118442..120370 Candidatus Blochmannia pennsylvanicus str. BPEN 3563182 YP_277617.1 CDS folP NC_007292.1 120501 121340 D ortholog to Escherichia coli bnum: b3177; MultiFun: Metabolism 1.5.3.2; 7,8-dihydropteroate synthase 120501..121340 Candidatus Blochmannia pennsylvanicus str. BPEN 3563183 YP_277618.1 CDS glmM NC_007292.1 121354 122715 D catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 121354..122715 Candidatus Blochmannia pennsylvanicus str. BPEN 3563184 YP_277619.1 CDS secG NC_007292.1 122862 123143 D general secretory pathway; ortholog to Escherichia coli bnum: b3175; MultiFun: Cell structure 6.1; Transport 4.3.A.5; Transport 4.S.160; preprotein translocase, membrane component 122862..123143 Candidatus Blochmannia pennsylvanicus str. BPEN 3563185 YP_277620.1 CDS nusA NC_007292.1 124047 125564 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 124047..125564 Candidatus Blochmannia pennsylvanicus str. BPEN 3563165 YP_277621.1 CDS infB NC_007292.1 125595 128270 D ortholog to Escherichia coli bnum: b3168; MultiFun: Information transfer 2.3.2; translation initiation factor IF-2 125595..128270 Candidatus Blochmannia pennsylvanicus str. BPEN 3563166 YP_277622.1 CDS rbfA NC_007292.1 128361 128720 D role in processing of 16S rRNA; ortholog to Escherichia coli bnum: b3167; MultiFun: Cell processes 5.5.2; Information transfer 2.2.3; 30S ribosome-binding factor 128361..128720 Candidatus Blochmannia pennsylvanicus str. BPEN 3563167 YP_277623.1 CDS truB NC_007292.1 128757 129539 D ortholog to Escherichia coli bnum: b3166; MultiFun: Information transfer 2.2.3; tRNA pseudouridine 5S synthase 128757..129539 Candidatus Blochmannia pennsylvanicus str. BPEN 3563168 YP_277624.1 CDS rpsO NC_007292.1 129869 130138 D ortholog to Escherichia coli bnum: b3165; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S15 129869..130138 Candidatus Blochmannia pennsylvanicus str. BPEN 3563169 YP_277625.1 CDS pnp NC_007292.1 130316 132415 D member of mRNA degradosome; ortholog to Escherichia coli bnum: b3164; MultiFun: Information transfer 2.2.4; Metabolism 1.2.1; polynucleotide phosphorylase 130316..132415 Candidatus Blochmannia pennsylvanicus str. BPEN 3563170 YP_277626.1 CDS deaD NC_007292.1 133041 134750 D ortholog to Escherichia coli bnum: b3162; MultiFun: Information transfer 2.2.3; cold-shock DeaD box ATP-dependent RNA helicase 133041..134750 Candidatus Blochmannia pennsylvanicus str. BPEN 3563171 YP_277627.1 CDS holD NC_007292.1 134912 135334 D ortholog to Escherichia coli bnum: b4372; MultiFun: Information transfer 2.1.1; DNA polymerase III subunit psi 134912..135334 Candidatus Blochmannia pennsylvanicus str. BPEN 3563172 YP_277628.1 CDS thrA NC_007292.1 136300 138750 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 136300..138750 Candidatus Blochmannia pennsylvanicus str. BPEN 3563173 YP_277629.1 CDS thrB NC_007292.1 138774 139712 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 138774..139712 Candidatus Blochmannia pennsylvanicus str. BPEN 3563174 YP_277630.1 CDS thrC NC_007292.1 139712 141013 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 139712..141013 Candidatus Blochmannia pennsylvanicus str. BPEN 3563120 YP_277631.1 CDS dnaK NC_007292.1 141383 143296 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 141383..143296 Candidatus Blochmannia pennsylvanicus str. BPEN 3563121 YP_277632.1 CDS dnaJ NC_007292.1 143420 144547 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 143420..144547 Candidatus Blochmannia pennsylvanicus str. BPEN 3563122 YP_277633.1 CDS rpsT NC_007292.1 144617 144883 R ortholog to Escherichia coli bnum: b0023; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S20 complement(144617..144883) Candidatus Blochmannia pennsylvanicus str. BPEN 3563123 YP_277634.1 CDS ribF NC_007292.1 145136 146110 D ortholog to Escherichia coli bnum: b0025; MultiFun: Metabolism 1.5.3.9; bifunctional flavokinase/FAD synthetase 145136..146110 Candidatus Blochmannia pennsylvanicus str. BPEN 3563124 YP_277635.1 CDS ileS NC_007292.1 146107 148935 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 146107..148935 Candidatus Blochmannia pennsylvanicus str. BPEN 3563125 YP_277636.1 CDS lspA NC_007292.1 148935 149432 D SPase II; ortholog to Escherichia coli bnum: b0027; MultiFun: Cell structure 6.1; Information transfer 2.3.5; Transport 4.S.160; prolipoprotein signal peptidase 148935..149432 Candidatus Blochmannia pennsylvanicus str. BPEN 3563126 YP_277637.1 CDS ispH NC_007292.1 149587 150522 D ortholog to Escherichia coli bnum: b0029; MultiFun: Cell processes 5.6.4; Metabolism 1.5.3.19; Regulation 3.1.4; 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase 149587..150522 Candidatus Blochmannia pennsylvanicus str. BPEN 3563127 YP_277638.1 CDS dapB NC_007292.1 150726 151574 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 150726..151574 Candidatus Blochmannia pennsylvanicus str. BPEN 3563160 YP_277639.1 CDS carA NC_007292.1 151822 152961 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 151822..152961 Candidatus Blochmannia pennsylvanicus str. BPEN 3563161 YP_277640.1 CDS carB NC_007292.1 152983 156210 D ortholog to Escherichia coli bnum: b0033; MultiFun: Metabolism 1.5.1.3, 1.5.2.2; carbamoyl-phosphate synthase large subunit 152983..156210 Candidatus Blochmannia pennsylvanicus str. BPEN 3563162 YP_277641.1 CDS folA NC_007292.1 156320 156814 D ortholog to Escherichia coli bnum: b0048; MultiFun: Metabolism 1.5.3.2, 1.7.17; dihydrofolate reductase type I 156320..156814 Candidatus Blochmannia pennsylvanicus str. BPEN 3563163 YP_277642.1 CDS apaH NC_007292.1 156974 157795 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(156974..157795) Candidatus Blochmannia pennsylvanicus str. BPEN 3563097 YP_277643.1 CDS ksgA NC_007292.1 158188 158991 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(158188..158991) Candidatus Blochmannia pennsylvanicus str. BPEN 3563098 YP_277644.1 CDS pdxA NC_007292.1 158972 159991 R ortholog to Escherichia coli bnum: b0052; MultiFun: Metabolism 1.5.3.6; pyridoxine phosphate biosynthetic protein PdxJ-PdxA subunit, NAD-dependent dehydrogenase/carboxylase complement(158972..159991) Candidatus Blochmannia pennsylvanicus str. BPEN 3563099 YP_277645.1 CDS surA NC_007292.1 159993 161270 R involved in maturation of outer membrane proteins; PPIase; ortholog to Escherichia coli bnum: b0053; MultiFun: Information transfer 2.3.4; peptidyl-prolyl cis-trans isomerase complement(159993..161270) Candidatus Blochmannia pennsylvanicus str. BPEN 3563100 YP_277646.1 CDS imp NC_007292.1 161321 163669 R ortholog to Escherichia coli bnum: b0054; MultiFun: Cell processes 5.5.6; Cell structure 6.1; organic solvent tolerance protein complement(161321..163669) Candidatus Blochmannia pennsylvanicus str. BPEN 3563101 YP_277647.1 CDS leuD NC_007292.1 164259 164867 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(164259..164867) Candidatus Blochmannia pennsylvanicus str. BPEN 3563102 YP_277648.1 CDS leuC NC_007292.1 164892 166292 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(164892..166292) Candidatus Blochmannia pennsylvanicus str. BPEN 3563103 YP_277649.1 CDS leuB NC_007292.1 166294 167394 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(166294..167394) Candidatus Blochmannia pennsylvanicus str. BPEN 3563104 YP_277650.1 CDS leuA NC_007292.1 167418 168971 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(167418..168971) Candidatus Blochmannia pennsylvanicus str. BPEN 3563105 YP_277651.1 CDS mraW NC_007292.1 169378 170367 D ortholog to Escherichia coli bnum: b0082; MultiFun: Metabolism 1.6.10; S-adenosyl-methyltransferase MraW 169378..170367 Candidatus Blochmannia pennsylvanicus str. BPEN 3563106 YP_277652.1 CDS ftsL NC_007292.1 170370 170684 D ortholog to Escherichia coli bnum: b0083; MultiFun: Cell processes 5.1; cell division protein 170370..170684 Candidatus Blochmannia pennsylvanicus str. BPEN 3563107 YP_277653.1 CDS ftsI NC_007292.1 170769 172463 D ortholog to Escherichia coli bnum: b0084; MultiFun: Cell processes 5.1, 5.6.4; Cell structure 6.1, 6.2; Metabolism 1.6.7; penicillin-binding protein 3; division-specific transpeptidase 170769..172463 Candidatus Blochmannia pennsylvanicus str. BPEN 3562862 YP_277654.1 CDS murE NC_007292.1 172499 174010 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 172499..174010 Candidatus Blochmannia pennsylvanicus str. BPEN 3562863 YP_277655.1 CDS murF NC_007292.1 174007 175380 D ortholog to Escherichia coli bnum: b0086; MultiFun: Cell processes 5.1; Cell structure 6.2; Metabolism 1.6.7, 1.7.34; D-alanine:D-alanine-adding enzyme 174007..175380 Candidatus Blochmannia pennsylvanicus str. BPEN 3562864 YP_277656.1 CDS mraY NC_007292.1 175365 176453 D ortholog to Escherichia coli bnum: b0087; MultiFun: Cell structure 6.1, 6.2; Metabolism 1.6.7; phospho-N-acetylmuramoyl-pentapeptide transferase 175365..176453 Candidatus Blochmannia pennsylvanicus str. BPEN 3562865 YP_277657.1 CDS murD NC_007292.1 176458 177780 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 176458..177780 Candidatus Blochmannia pennsylvanicus str. BPEN 3562866 YP_277658.1 CDS ftsW NC_007292.1 177780 178976 D ortholog to Escherichia coli bnum: b0089; MultiFun: Cell processes 5.1; Cell structure 6.1; Transport 4.9.B.3; cell division protein 177780..178976 Candidatus Blochmannia pennsylvanicus str. BPEN 3562867 YP_277659.1 CDS murG NC_007292.1 178973 180040 D ortholog to Escherichia coli bnum: b0090; MultiFun: Cell structure 6.1, 6.2; Metabolism 1.6.7; UDP-N-acetylglucosamine:N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 178973..180040 Candidatus Blochmannia pennsylvanicus str. BPEN 3562868 YP_277660.1 CDS murC NC_007292.1 180099 181541 D ortholog to Escherichia coli bnum: b0091; MultiFun: Cell structure 6.2; Metabolism 1.6.7; UDP-N-acetyl-muramate:alanine ligase 180099..181541 Candidatus Blochmannia pennsylvanicus str. BPEN 3562869 YP_277661.1 CDS ftsQ NC_007292.1 181677 182471 D ortholog to Escherichia coli bnum: b0093; MultiFun: Cell processes 5.1; cell division protein 181677..182471 Candidatus Blochmannia pennsylvanicus str. BPEN 3562870 YP_277662.1 CDS ftsA NC_007292.1 182506 183762 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 182506..183762 Candidatus Blochmannia pennsylvanicus str. BPEN 3562871 YP_277663.1 CDS ftsZ NC_007292.1 183838 185004 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 183838..185004 Candidatus Blochmannia pennsylvanicus str. BPEN 3562872 YP_277664.1 CDS lpxC NC_007292.1 185108 186001 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 185108..186001 Candidatus Blochmannia pennsylvanicus str. BPEN 3563086 YP_277665.1 CDS secA NC_007292.1 186811 189546 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 186811..189546 Candidatus Blochmannia pennsylvanicus str. BPEN 3563087 YP_277666.1 CDS coaE NC_007292.1 189805 190443 R ortholog to Escherichia coli bnum: b0103; MultiFun: Metabolism 1.5.3.5; dephospho-CoA kinase complement(189805..190443) Candidatus Blochmannia pennsylvanicus str. BPEN 3563088 YP_277667.1 CDS dksA NC_007292.1 191027 191491 D ortholog to Escherichia coli bnum: b0145; MultiFun: Information transfer 2.3.4; dosage-dependent dnaK suppressor protein 191027..191491 Candidatus Blochmannia pennsylvanicus str. BPEN 3563089 YP_277668.1 CDS folK NC_007292.1 191738 192232 D ortholog to Escherichia coli bnum: b0142; MultiFun: Metabolism 1.5.3.2; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 191738..192232 Candidatus Blochmannia pennsylvanicus str. BPEN 3563090 YP_277669.1 CDS lpdA NC_007292.1 193981 195405 R ortholog to Escherichia coli bnum: b0116; MultiFun: Metabolism 1.1.1.20, 1.1.3.5, 1.3.3, 1.3.4, 1.3.6, 1.3.7, 1.7.17, 1.7.21; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, E3 component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes complement(193981..195405) Candidatus Blochmannia pennsylvanicus str. BPEN 3563091 YP_277670.1 CDS aceF NC_007292.1 195617 196888 R ortholog to Escherichia coli bnum: b0115; MultiFun: Metabolism 1.1.1.20, 1.3.3, 1.3.7, 1.7.21, 1.7.35; branched-chain alpha-keto acid dehydrogenase subunit E2 complement(195617..196888) Candidatus Blochmannia pennsylvanicus str. BPEN 3563092 YP_277671.1 CDS aceE NC_007292.1 196900 199566 R E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 complement(196900..199566) Candidatus Blochmannia pennsylvanicus str. BPEN 3563093 YP_277672.1 CDS mrcB NC_007292.1 201636 203972 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 201636..203972 Candidatus Blochmannia pennsylvanicus str. BPEN 3563094 YP_277673.1 CDS yadR NC_007292.1 204313 204666 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 204313..204666 Candidatus Blochmannia pennsylvanicus str. BPEN 3563095 YP_277674.1 CDS pyrG NC_007292.1 205130 206776 D CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 205130..206776 Candidatus Blochmannia pennsylvanicus str. BPEN 3563096 YP_277675.1 CDS eno NC_007292.1 206853 208151 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 206853..208151 Candidatus Blochmannia pennsylvanicus str. BPEN 3563108 YP_277676.1 CDS cysJ NC_007292.1 208744 210564 D ortholog to Escherichia coli bnum: b2764; MultiFun: Metabolism 1.8.2; sulfite reductase subunit alpha (flavoprotein) 208744..210564 Candidatus Blochmannia pennsylvanicus str. BPEN 3563109 YP_277677.1 CDS cysI NC_007292.1 210564 212291 D hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 210564..212291 Candidatus Blochmannia pennsylvanicus str. BPEN 3563110 YP_277678.1 CDS cysH NC_007292.1 212284 213045 D catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 212284..213045 Candidatus Blochmannia pennsylvanicus str. BPEN 3563111 YP_277679.1 CDS cysG NC_007292.1 213326 214750 D ortholog to Escherichia coli bnum: b3368; MultiFun: Metabolism 1.5.3.12; multifunctional siroheme synthase: uroporphyrinogen methyltransferase; siroheme ferrochelatase; 1,3-dimethyluroporphyriongen III dehydrogenase 213326..214750 Candidatus Blochmannia pennsylvanicus str. BPEN 3563112 YP_277680.1 CDS cysD NC_007292.1 214767 215681 D with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 214767..215681 Candidatus Blochmannia pennsylvanicus str. BPEN 3563113 YP_277681.1 CDS cysN NC_007292.1 215691 217121 D ortholog to Escherichia coli bnum: b2751; MultiFun: Metabolism 1.8.2; ATP:sulfate adenylyltransferase; ATP-sulfurylase, subunit 1 215691..217121 Candidatus Blochmannia pennsylvanicus str. BPEN 3563114 YP_277682.1 CDS cysC NC_007292.1 217135 217770 D ortholog to Escherichia coli bnum: b2750; MultiFun: Metabolism 1.8.2; adenosine 5'-phosphosulfate kinase 217135..217770 Candidatus Blochmannia pennsylvanicus str. BPEN 3563115 YP_277683.1 CDS ygbQ NC_007292.1 218140 218415 D ortholog to Escherichia coli bnum: b2748; MultiFun: Cell processes 5.1; Cell structure 6.1; cell division protein 218140..218415 Candidatus Blochmannia pennsylvanicus str. BPEN 3563116 YP_277684.1 CDS ispD NC_007292.1 218487 219194 D ortholog to Escherichia coli bnum: b2747; MultiFun: Metabolism 1.5.3.19; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase 218487..219194 Candidatus Blochmannia pennsylvanicus str. BPEN 3563117 YP_277685.1 CDS ispF NC_007292.1 219209 219682 D ortholog to Escherichia coli bnum: b2746; MultiFun: Metabolism 1.5.3.19; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 219209..219682 Candidatus Blochmannia pennsylvanicus str. BPEN 3563118 YP_277686.1 CDS nlpD NC_007292.1 220332 221285 D ortholog to Escherichia coli bnum: b2742; MultiFun: Cell structure 6.1; lipoprotein NlpD 220332..221285 Candidatus Blochmannia pennsylvanicus str. BPEN 3563119 YP_277687.1 CDS alaS NC_007292.1 222183 224822 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 222183..224822 Candidatus Blochmannia pennsylvanicus str. BPEN 3562669 YP_277688.1 CDS csrA NC_007292.1 225010 225195 D post-translational activator of flhDC expression; regulates biofilm formation; RNA-binding; ortholog to Escherichia coli bnum: b2696; MultiFun: Cell processes 5.3; Information transfer 2.2.4; Metabolism 1.1.1, 1.3.1, 1.6.9, 1.7.8; Regulation 3.1.3.1, 3.3.4; carbon storage regulator 225010..225195 Candidatus Blochmannia pennsylvanicus str. BPEN 3562670 YP_277689.1 CDS ffh NC_007292.1 225699 227060 D GTP-binding export factor; part of signal recognition particle with 4.5 RNA; ortholog to Escherichia coli bnum: b2610; MultiFun: Transport 4.3.A.5; Transport 4.S.160; 4.5S-RNP protein 225699..227060 Candidatus Blochmannia pennsylvanicus str. BPEN 3562673 YP_277690.1 CDS rpsP NC_007292.1 227157 227399 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 227157..227399 Candidatus Blochmannia pennsylvanicus str. BPEN 3562674 YP_277691.1 CDS rimM NC_007292.1 227396 227965 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 227396..227965 Candidatus Blochmannia pennsylvanicus str. BPEN 3562675 YP_277692.1 CDS trmD NC_007292.1 227992 228759 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 227992..228759 Candidatus Blochmannia pennsylvanicus str. BPEN 3562676 YP_277693.1 CDS rplS NC_007292.1 228767 229117 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 228767..229117 Candidatus Blochmannia pennsylvanicus str. BPEN 3562677 YP_277694.1 CDS aroF NC_007292.1 229622 230707 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 229622..230707 Candidatus Blochmannia pennsylvanicus str. BPEN 3562678 YP_277695.1 CDS tyrA NC_007292.1 230704 231831 D catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 230704..231831 Candidatus Blochmannia pennsylvanicus str. BPEN 3562903 YP_277696.1 CDS pheA NC_007292.1 232079 232969 R bifunctional; ortholog to Escherichia coli bnum: b2599; MultiFun: Metabolism 1.5.1.13, 1.5.1.14; prephenate dehydratase; chorismate mutase P complement(232079..232969) Candidatus Blochmannia pennsylvanicus str. BPEN 3562904 YP_277697.1 CDS yfiO NC_007292.1 233191 233934 R ortholog to Escherichia coli bnum: b2595; MultiFun: Cell structure 6.1; lipoprotein complement(233191..233934) Candidatus Blochmannia pennsylvanicus str. BPEN 3562905 YP_277698.1 CDS rluD NC_007292.1 234005 235036 D pseudouridines 1911, 1915, 1917 in 23S RNA; ortholog to Escherichia coli bnum: b2594; MultiFun: Information transfer 2.2.3; pseudouridine synthase 234005..235036 Candidatus Blochmannia pennsylvanicus str. BPEN 3562906 YP_277699.1 CDS clpB NC_007292.1 235325 237901 D part of novel multi-chaperone; ortholog to Escherichia coli bnum: b2592; MultiFun: Information transfer 2.3.4; Metabolism 1.2.3; Hsp 100; ATP-dependent protease 235325..237901 Candidatus Blochmannia pennsylvanicus str. BPEN 3562907 YP_277700.1 CDS murB NC_007292.1 238230 239267 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 238230..239267 Candidatus Blochmannia pennsylvanicus str. BPEN 3562908 YP_277701.1 CDS birA NC_007292.1 239424 240239 D bifunctional; ortholog to Escherichia coli bnum: b3973; MultiFun: Information transfer 2.2.2; Metabolism 1.5.3.1; Regulation 3.1.2.3, 3.3.1; transcriptional repressor of biotin synthesis (BirA family); biotin-[acetylCoA carboxylase] holoenzyme synthetase 239424..240239 Candidatus Blochmannia pennsylvanicus str. BPEN 3562909 YP_277702.1 CDS coaA NC_007292.1 240388 241329 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(240388..241329) Candidatus Blochmannia pennsylvanicus str. BPEN 3562910 YP_277703.1 CDS bfr NC_007292.1 242155 242625 D ortholog to Escherichia coli bnum: b3336; MultiFun: Cell processes 5.5.7; bacterioferritin 242155..242625 Candidatus Blochmannia pennsylvanicus str. BPEN 3562703 YP_277704.1 CDS rpsJ NC_007292.1 242945 243256 D ortholog to Escherichia coli bnum: b3321; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S10 242945..243256 Candidatus Blochmannia pennsylvanicus str. BPEN 3562704 YP_277705.1 CDS rplC NC_007292.1 243362 244015 D ortholog to Escherichia coli bnum: b3320; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L3 243362..244015 Candidatus Blochmannia pennsylvanicus str. BPEN 3562705 YP_277706.1 CDS rplD NC_007292.1 244016 244648 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 244016..244648 Candidatus Blochmannia pennsylvanicus str. BPEN 3562706 YP_277707.1 CDS rplW NC_007292.1 244645 244947 D ortholog to Escherichia coli bnum: b3318; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L23 244645..244947 Candidatus Blochmannia pennsylvanicus str. BPEN 3562707 YP_277708.1 CDS rplB NC_007292.1 244971 245798 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 244971..245798 Candidatus Blochmannia pennsylvanicus str. BPEN 3562708 YP_277709.1 CDS rpsS NC_007292.1 245825 246106 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 245825..246106 Candidatus Blochmannia pennsylvanicus str. BPEN 3562709 YP_277710.1 CDS rplV NC_007292.1 246156 246485 D ortholog to Escherichia coli bnum: b3315; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L22 246156..246485 Candidatus Blochmannia pennsylvanicus str. BPEN 3562710 YP_277711.1 CDS rpsC NC_007292.1 246519 247229 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 246519..247229 Candidatus Blochmannia pennsylvanicus str. BPEN 3562711 YP_277712.1 CDS rplP NC_007292.1 247241 247645 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 247241..247645 Candidatus Blochmannia pennsylvanicus str. BPEN 3562746 YP_277713.1 CDS rpmC NC_007292.1 247645 247857 D ortholog to Escherichia coli bnum: b3312; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L29 247645..247857 Candidatus Blochmannia pennsylvanicus str. BPEN 3562747 YP_277714.1 CDS rpsQ NC_007292.1 247872 248126 D ortholog to Escherichia coli bnum: b3311; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S17 247872..248126 Candidatus Blochmannia pennsylvanicus str. BPEN 3562748 YP_277715.1 CDS rplN NC_007292.1 248249 248620 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 248249..248620 Candidatus Blochmannia pennsylvanicus str. BPEN 3562749 YP_277716.1 CDS rplX NC_007292.1 248636 248956 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 248636..248956 Candidatus Blochmannia pennsylvanicus str. BPEN 3562750 YP_277717.1 CDS rplE NC_007292.1 248969 249508 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 248969..249508 Candidatus Blochmannia pennsylvanicus str. BPEN 3562751 YP_277718.1 CDS rpsN NC_007292.1 249541 249846 D ortholog to Escherichia coli bnum: b3307; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S14 249541..249846 Candidatus Blochmannia pennsylvanicus str. BPEN 3562752 YP_277719.1 CDS rpsH NC_007292.1 249878 250273 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 249878..250273 Candidatus Blochmannia pennsylvanicus str. BPEN 3562753 YP_277720.1 CDS rplF NC_007292.1 250263 250829 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 250263..250829 Candidatus Blochmannia pennsylvanicus str. BPEN 3562754 YP_277721.1 CDS rplR NC_007292.1 250861 251214 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 250861..251214 Candidatus Blochmannia pennsylvanicus str. BPEN 3562755 YP_277722.1 CDS rpsE NC_007292.1 251230 251754 D ortholog to Escherichia coli bnum: b3303; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 30S ribosomal protein S5 251230..251754 Candidatus Blochmannia pennsylvanicus str. BPEN 3562850 YP_277723.1 CDS rplO NC_007292.1 251937 252371 D ortholog to Escherichia coli bnum: b3301; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L15 251937..252371 Candidatus Blochmannia pennsylvanicus str. BPEN 3562852 YP_277724.1 CDS secY NC_007292.1 252382 253719 D general secretory pathway; ortholog to Escherichia coli bnum: b3300; MultiFun: Cell structure 6.1; Transport 4.3.A.5, 4.S.160; preprotein translocase, membrane component 252382..253719 Candidatus Blochmannia pennsylvanicus str. BPEN 3562853 YP_277725.1 CDS rmpJ NC_007292.1 253758 253874 D ortholog to Escherichia coli bnum: b3299; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L36 253758..253874 Candidatus Blochmannia pennsylvanicus str. BPEN 3562854 YP_277726.1 CDS rpsM NC_007292.1 253923 254288 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 253923..254288 Candidatus Blochmannia pennsylvanicus str. BPEN 3562855 YP_277727.1 CDS rpsK NC_007292.1 254320 254712 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 254320..254712 Candidatus Blochmannia pennsylvanicus str. BPEN 3562856 YP_277728.1 CDS rpsD NC_007292.1 254750 255373 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 254750..255373 Candidatus Blochmannia pennsylvanicus str. BPEN 3562857 YP_277729.1 CDS rpoA NC_007292.1 255408 256400 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 255408..256400 Candidatus Blochmannia pennsylvanicus str. BPEN 3562858 YP_277730.1 CDS rplQ NC_007292.1 256441 256818 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 256441..256818 Candidatus Blochmannia pennsylvanicus str. BPEN 3562859 YP_277731.1 CDS fmt NC_007292.1 256879 257847 R ortholog to Escherichia coli bnum: b3288; MultiFun: Information transfer 2.2.3; methionyl-tRNA formyltransferase complement(256879..257847) Candidatus Blochmannia pennsylvanicus str. BPEN 3562860 YP_277732.1 CDS def NC_007292.1 257858 258379 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(257858..258379) Candidatus Blochmannia pennsylvanicus str. BPEN 3562861 YP_277733.1 CDS yrdC NC_007292.1 258767 259351 D ortholog to Escherichia coli bnum: b3282; RNA-binding protein 258767..259351 Candidatus Blochmannia pennsylvanicus str. BPEN 3563157 YP_277734.1 CDS aroE NC_007292.1 259379 260254 D AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 259379..260254 Candidatus Blochmannia pennsylvanicus str. BPEN 3562942 YP_277735.1 CDS gloB NC_007292.1 260930 261685 R ortholog to Escherichia coli bnum: b0212; MultiFun: Metabolism 1.7.23; hydroxyacylglutathione hydrolase complement(260930..261685) Candidatus Blochmannia pennsylvanicus str. BPEN 3562806 YP_277736.1 CDS rnhA NC_007292.1 261986 262441 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(261986..262441) Candidatus Blochmannia pennsylvanicus str. BPEN 3562616 YP_277737.1 CDS dnaQ NC_007292.1 262500 263249 D ortholog to Escherichia coli bnum: b0215; MultiFun: Information transfer 2.1.1, 2.3.4; DNA polymerase III subunit epsilon 262500..263249 Candidatus Blochmannia pennsylvanicus str. BPEN 3562617 YP_277738.1 CDS gmhA NC_007292.1 263467 264054 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 263467..264054 Candidatus Blochmannia pennsylvanicus str. BPEN 3562618 YP_277739.1 CDS ahpC NC_007292.1 264460 265062 R ortholog to Escherichia coli bnum: b0605; MultiFun: Cell processes 5.6.2; alkyl hydroperoxide reductase complement(264460..265062) Candidatus Blochmannia pennsylvanicus str. BPEN 3562620 YP_277740.1 CDS tgt NC_007292.1 266542 267648 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 266542..267648 Candidatus Blochmannia pennsylvanicus str. BPEN 3562770 YP_277741.1 CDS yajC NC_007292.1 267721 268068 D general secretory pathway; ortholog to Escherichia coli bnum: b0407; MultiFun: Cell structure 6.1; Transport 4.3.A.5, 4.S.160; preprotein translocase, auxillary membrane component 267721..268068 Candidatus Blochmannia pennsylvanicus str. BPEN 3562771 YP_277742.1 CDS secD NC_007292.1 268103 269962 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 268103..269962 Candidatus Blochmannia pennsylvanicus str. BPEN 3562772 YP_277743.1 CDS secF NC_007292.1 270024 270941 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 270024..270941 Candidatus Blochmannia pennsylvanicus str. BPEN 3562773 YP_277744.1 CDS ribD NC_007292.1 271407 272546 D bifunctional; ortholog to Escherichia coli bnum: b0414; pathway of riboflavin synthesis; MultiFun: Metabolism 1.5.3.9; pyrimidine deaminase/reductase 271407..272546 Candidatus Blochmannia pennsylvanicus str. BPEN 3562774 YP_277745.1 CDS ribH NC_007292.1 272651 273127 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 272651..273127 Candidatus Blochmannia pennsylvanicus str. BPEN 3562775 YP_277746.1 CDS nusB NC_007292.1 273155 273589 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 273155..273589 Candidatus Blochmannia pennsylvanicus str. BPEN 3562776 YP_277747.1 CDS pgpA NC_007292.1 273677 274168 D ortholog to Escherichia coli bnum: b0418; MultiFun: Cell structure 6.1; Metabolism 1.6.1; phosphatidylglycerophosphatase A 273677..274168 Candidatus Blochmannia pennsylvanicus str. BPEN 3562777 YP_277748.1 CDS dxs NC_007292.1 274265 276139 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(274265..276139) Candidatus Blochmannia pennsylvanicus str. BPEN 3562778 YP_277749.1 CDS ispA NC_007292.1 276175 277095 R ortholog to Escherichia coli bnum: b0421; MultiFun: Metabolism 1.5.3.19; geranyltranstransferase complement(276175..277095) Candidatus Blochmannia pennsylvanicus str. BPEN 3562779 YP_277750.1 CDS thiI NC_007292.1 277383 278843 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 277383..278843 Candidatus Blochmannia pennsylvanicus str. BPEN 3562780 YP_277751.1 CDS yajR NC_007292.1 279173 280333 R ortholog to Escherichia coli bnum: b0427; MultiFun: Cell processes 5.6.4; Cell structure 6.1; Transport 4.2.A.1,4.S.49; MFS family transporter complement(279173..280333) Candidatus Blochmannia pennsylvanicus str. BPEN 3562781 YP_277752.1 CDS cyoE NC_007292.1 280494 281378 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(280494..281378) Candidatus Blochmannia pennsylvanicus str. BPEN 3562797 YP_277753.1 CDS cyoD NC_007292.1 281398 281700 R ortholog to Escherichia coli bnum: b0429; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; cytochrome o ubiquinol oxidase, subunit IV complement(281398..281700) Candidatus Blochmannia pennsylvanicus str. BPEN 3562798 YP_277754.1 CDS cyoC NC_007292.1 281704 282291 R ortholog to Escherichia coli bnum: b0430; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; Transport 4.3.D.4, 4.S.82; cytochrome o ubiquinol oxidase subunit III complement(281704..282291) Candidatus Blochmannia pennsylvanicus str. BPEN 3562799 YP_277755.1 CDS cyoB NC_007292.1 282269 284230 R ortholog to Escherichia coli bnum: b0431; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; Transport 4.3.D.4, 4.S.82; cytochrome o ubiquinol oxidase subunit I complement(282269..284230) Candidatus Blochmannia pennsylvanicus str. BPEN 3562800 YP_277756.1 CDS cyoA NC_007292.1 284306 285190 R ortholog to Escherichia coli bnum: b0432; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.4.2; Transport 4.3.D.4, 4.S.82; cytochrome o ubiquinol oxidase subunit II complement(284306..285190) Candidatus Blochmannia pennsylvanicus str. BPEN 3562801 YP_277757.1 CDS clpP NC_007292.1 287418 288044 D ortholog to Escherichia coli bnum: b0437; MultiFun: Cell processes 5.5.2; Metabolism 1.2.3; Regulation 3.1.3.4; ATP-dependent Clp protease proteolytic subunit 287418..288044 Candidatus Blochmannia pennsylvanicus str. BPEN 3562802 YP_277758.1 CDS clpX NC_007292.1 288183 289442 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 288183..289442 Candidatus Blochmannia pennsylvanicus str. BPEN 3562803 YP_277759.1 CDS yggX NC_007292.1 289623 289877 R ortholog to Escherichia coli bnum: b2962; hypothetical protein complement(289623..289877) Candidatus Blochmannia pennsylvanicus str. BPEN 3562804 YP_277760.1 CDS mutY NC_007292.1 289949 290998 R ortholog to Escherichia coli bnum: b2961; MultiFun: Information transfer 2.1.4; adenine DNA glycosylase complement(289949..290998) Candidatus Blochmannia pennsylvanicus str. BPEN 3563139 YP_277761.1 CDS yqgF NC_007292.1 291941 292375 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(291941..292375) Candidatus Blochmannia pennsylvanicus str. BPEN 3562899 YP_277762.1 CDS yqgE NC_007292.1 292368 292952 R ortholog to Escherichia coli bnum: b2948; hypothetical protein complement(292368..292952) Candidatus Blochmannia pennsylvanicus str. BPEN 3562924 YP_277763.1 CDS metK NC_007292.1 293740 294909 R catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(293740..294909) Candidatus Blochmannia pennsylvanicus str. BPEN 3562925 YP_277764.1 CDS speB NC_007292.1 295662 296582 D catalyzes the formation of putrescine from agmatine; agmatinase 295662..296582 Candidatus Blochmannia pennsylvanicus str. BPEN 3563140 YP_277765.1 CDS pgk NC_007292.1 297078 298262 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 297078..298262 Candidatus Blochmannia pennsylvanicus str. BPEN 3562603 YP_277766.1 CDS fbaA NC_007292.1 298347 299429 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 298347..299429 Candidatus Blochmannia pennsylvanicus str. BPEN 3562604 YP_277767.1 CDS rpiA NC_007292.1 299768 300424 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 299768..300424 Candidatus Blochmannia pennsylvanicus str. BPEN 3562605 YP_277768.1 CDS ygfA NC_007292.1 300664 301275 R ortholog to Escherichia coli bnum: b2912; ligase complement(300664..301275) Candidatus Blochmannia pennsylvanicus str. BPEN 3562606 YP_277769.1 CDS ygfE NC_007292.1 301417 301761 R ortholog to Escherichia coli bnum: b2910; Z-ring-associated protein complement(301417..301761) Candidatus Blochmannia pennsylvanicus str. BPEN 3562947 YP_277770.1 CDS ubiH NC_007292.1 302617 303807 D ortholog to Escherichia coli bnum: b2907; MultiFun: Metabolism 1.3.6, 1.5.3.11; 2-octaprenyl-6-methoxyphenol hydroxylase 302617..303807 Candidatus Blochmannia pennsylvanicus str. BPEN 3562948 YP_277771.1 CDS visC NC_007292.1 303831 305054 D ortholog to Escherichia coli bnum: b2906; monooxygenase 303831..305054 Candidatus Blochmannia pennsylvanicus str. BPEN 3562607 YP_277772.1 CDS ygfZ NC_007292.1 305107 306099 R ortholog to Escherichia coli bnum: b2898; aminomethyltransferase complement(305107..306099) Candidatus Blochmannia pennsylvanicus str. BPEN 3562608 YP_277773.1 CDS prfB NC_007292.1 306663 307709 D ortholog to Escherichia coli bnum: b2891; MultiFun: Information transfer 2.3.2; peptide chain release factor 2 306663..307709 Candidatus Blochmannia pennsylvanicus str. BPEN 3562609 YP_277774.1 CDS lysS NC_007292.1 307702 309231 D ortholog to Escherichia coli bnum: b2890; MultiFun: Information transfer 2.3.1; lysyl-tRNA synthetase 307702..309231 Candidatus Blochmannia pennsylvanicus str. BPEN 3562610 YP_277775.1 CDS lysA NC_007292.1 309411 310700 D catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 309411..310700 Candidatus Blochmannia pennsylvanicus str. BPEN 3562611 YP_277776.1 CDS ygdP NC_007292.1 311330 311806 D hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 311330..311806 Candidatus Blochmannia pennsylvanicus str. BPEN 3563209 YP_277777.1 CDS lgt NC_007292.1 311989 312834 D transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 311989..312834 Candidatus Blochmannia pennsylvanicus str. BPEN 3563210 YP_277778.1 CDS recC NC_007292.1 313298 316699 D ortholog to Escherichia coli bnum: b2822; with recB and recD: 5' and 3' nuclease, ATPase, recombinase, helicase; MultiFun: Information transfer 2.1.3, 2.1.5; Metabolism 1.2.2; exonuclease V subunit gamma 313298..316699 Candidatus Blochmannia pennsylvanicus str. BPEN 3563211 YP_277779.1 CDS recD NC_007292.1 316824 318731 R ortholog to Escherichia coli bnum: b2819; with recC and recD: 5' and 3' nuclease, ATPase, recombinase, helicase; MultiFun: Information transfer 2.1.3, 2.1.5; Metabolism 1.2.2; exonuclease V subunit alpha complement(316824..318731) Candidatus Blochmannia pennsylvanicus str. BPEN 3563212 YP_277780.1 CDS recB NC_007292.1 319015 322578 R beta chain with recC and recD; 5' and 3' nuclease, ATPase, recombinase, helicase; ortholog to Escherichia coli bnum: b2820; MultiFun: Information transfer 2.1.3, 2.1.5; Metabolism 1.2.2; exonuclease V complement(319015..322578) Candidatus Blochmannia pennsylvanicus str. BPEN 3563213 YP_277781.2 CDS dapD NC_007292.1 322804 323625 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(322804..323625) Candidatus Blochmannia pennsylvanicus str. BPEN 3563214 YP_277782.1 CDS map NC_007292.1 324077 324859 R ortholog to Escherichia coli bnum: b0168; MultiFun: Information transfer 2.3.4; methionine aminopeptidase complement(324077..324859) Candidatus Blochmannia pennsylvanicus str. BPEN 3563215 YP_277783.1 CDS rpsB NC_007292.1 325186 325872 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 325186..325872 Candidatus Blochmannia pennsylvanicus str. BPEN 3563216 YP_277784.1 CDS tsf NC_007292.1 325958 326776 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 325958..326776 Candidatus Blochmannia pennsylvanicus str. BPEN 3563217 YP_277785.1 CDS pyrH NC_007292.1 326982 327707 D ortholog to Escherichia coli bnum: b0171; MultiFun: Metabolism 1.7.33; uridylate kinase 326982..327707 Candidatus Blochmannia pennsylvanicus str. BPEN 3563218 YP_277786.1 CDS frr NC_007292.1 327793 328359 D ortholog to Escherichia coli bnum: b0172; MultiFun: Information transfer 2.3.2; Regulation 3.1.3.1; ribosome recycling factor 327793..328359 Candidatus Blochmannia pennsylvanicus str. BPEN 3563219 YP_277787.1 CDS dxr NC_007292.1 328454 329647 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 328454..329647 Candidatus Blochmannia pennsylvanicus str. BPEN 3562592 YP_277788.1 CDS uppS NC_007292.1 329804 330556 D ortholog to Escherichia coli bnum: b0174; MultiFun: Cell structure 6.3; Metabolism 1.5.3.19; undecaprenyl pyrophosphate synthetase 329804..330556 Candidatus Blochmannia pennsylvanicus str. BPEN 3562593 YP_277789.1 CDS cdsA NC_007292.1 330588 331448 D ortholog to Escherichia coli bnum: b0175; MultiFun: Cell structure 6.1; Metabolism 1.6.1; phosphatidate cytidylyltransferase 330588..331448 Candidatus Blochmannia pennsylvanicus str. BPEN 3562594 YP_277790.1 CDS ecfE NC_007292.1 331484 332857 D ortholog to Escherichia coli bnum: b0176; MultiFun: Cell processes 5.5; Cell structure 6.1; Regulation 3.1.3.4; hypothetical protein 331484..332857 Candidatus Blochmannia pennsylvanicus str. BPEN 3562595 YP_277791.1 CDS yaeT NC_007292.1 332902 335325 D ortholog to Escherichia coli bnum: b0177; MultiFun: Cell structure 6.1; hypothetical protein 332902..335325 Candidatus Blochmannia pennsylvanicus str. BPEN 3562596 YP_277792.1 CDS hlpA NC_007292.1 335405 335905 D ortholog to Escherichia coli bnum: b0178; located in outer membrane; MultiFun: Cell structure 6.1; Information transfer 2.3.4, 2.3.7; histone-like protein 335405..335905 Candidatus Blochmannia pennsylvanicus str. BPEN 3562597 YP_277793.1 CDS lpxD NC_007292.1 335909 336940 D ortholog to Escherichia coli bnum: b0179; MultiFun: Cell structure 6.3; Metabolism 1.6.3.3; UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase 335909..336940 Candidatus Blochmannia pennsylvanicus str. BPEN 3562598 YP_277794.1 CDS fabZ NC_007292.1 337040 337495 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 337040..337495 Candidatus Blochmannia pennsylvanicus str. BPEN 3562927 YP_277795.1 CDS lpxA NC_007292.1 337500 338288 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 337500..338288 Candidatus Blochmannia pennsylvanicus str. BPEN 3562928 YP_277796.1 CDS lpxB NC_007292.1 338291 339454 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 338291..339454 Candidatus Blochmannia pennsylvanicus str. BPEN 3562929 YP_277797.1 CDS rnhB NC_007292.1 339451 340104 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 339451..340104 Candidatus Blochmannia pennsylvanicus str. BPEN 3562930 YP_277798.1 CDS dnaE NC_007292.1 340151 343642 D ortholog to Escherichia coli bnum: b0184; MultiFun: Information transfer 2.1.1; DNA polymerase III subunit alpha 340151..343642 Candidatus Blochmannia pennsylvanicus str. BPEN 3562839 YP_277799.1 CDS accA NC_007292.1 343661 344620 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 343661..344620 Candidatus Blochmannia pennsylvanicus str. BPEN 3562840 YP_277800.1 CDS tilS NC_007292.1 344776 346308 D cell cycle protein; ortholog to Escherichia coli bnum: b0188; MultiFun: Information transfer 2.2.3; tRNA(Ile)-lysidine synthetase 344776..346308 Candidatus Blochmannia pennsylvanicus str. BPEN 3562841 YP_277801.1 CDS proS NC_007292.1 346510 348255 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(346510..348255) Candidatus Blochmannia pennsylvanicus str. BPEN 3562842 YP_277802.1 CDS gmhB NC_007292.1 348625 349209 D ortholog to Escherichia coli bnum: b0200; MultiFun: Metabolism 1.6.3.2; D,D-heptose 1,7-bisphosphate phosphatase 348625..349209 Candidatus Blochmannia pennsylvanicus str. BPEN 3562843 YP_277803.1 CDS accC NC_007292.1 349344 350699 R ortholog to Escherichia coli bnum: b3256; MultiFun: Metabolism 1.5.4; acetyl CoA carboxylase, biotin carboxylase subunit complement(349344..350699) Candidatus Blochmannia pennsylvanicus str. BPEN 3562844 YP_277804.1 CDS accB NC_007292.1 350710 351162 R carrier of biotin; ortholog to Escherichia coli bnum: b3255; MultiFun: Metabolism 1.6.15.3; acetylCoA carboxylase BCCP subunit complement(350710..351162) Candidatus Blochmannia pennsylvanicus str. BPEN 3562845 YP_277805.1 CDS aroQ NC_007292.1 351184 351642 R catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase complement(351184..351642) Candidatus Blochmannia pennsylvanicus str. BPEN 3562846 YP_277806.1 CDS mreB NC_007292.1 352331 353374 D functions in MreBCD complex in some organisms; rod shape-determining protein MreB 352331..353374 Candidatus Blochmannia pennsylvanicus str. BPEN 3562847 YP_277807.1 CDS mreC NC_007292.1 353495 354310 D in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 353495..354310 Candidatus Blochmannia pennsylvanicus str. BPEN 3562848 YP_277808.1 CDS mreD NC_007292.1 354421 354900 D ortholog to Escherichia coli bnum: b3249; MultiFun: Cell structure 6.1, 6.2; Metabolism 1.6.7; rod shape-determining protein 354421..354900 Candidatus Blochmannia pennsylvanicus str. BPEN 3562849 YP_277809.1 CDS tldD NC_007292.1 355310 356773 D enzyme for maturation of Microcin B17 and degradation of CcdA with winged helix domain; ortholog to Escherichia coli bnum: b3244; MultiFun: Cell processes 5.1; Information transfer 2.3.5; hypothetical protein 355310..356773 Candidatus Blochmannia pennsylvanicus str. BPEN 3562582 YP_277810.1 CDS pmbA NC_007292.1 357217 358557 D enzyme for maturation of Microcin B17 and degradation of CcdA; ortholog to Escherichia coli bnum: b4235; MultiFun: Cell processes 5.1, 5.6.3; Information transfer 2.3.5; hypothetical protein 357217..358557 Candidatus Blochmannia pennsylvanicus str. BPEN 3562583 YP_277811.1 CDS lon NC_007292.1 359892 362255 D ortholog to Escherichia coli bnum: b0439; MultiFun: Metabolism 1.2.3; Regulation 3.1.3.4; DNA-binding ATP-dependent protease La 359892..362255 Candidatus Blochmannia pennsylvanicus str. BPEN 3562584 YP_277812.1 CDS apt NC_007292.1 363915 364469 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 363915..364469 Candidatus Blochmannia pennsylvanicus str. BPEN 3562585 YP_277813.1 CDS dnaX NC_007292.1 364540 366636 D ortholog to Escherichia coli bnum: b0470; MultiFun: Information transfer 2.1.1; DNA polymerase III, tau and gamma subunits 364540..366636 Candidatus Blochmannia pennsylvanicus str. BPEN 3562586 YP_277814.1 CDS adk NC_007292.1 367270 367923 D ortholog to Escherichia coli bnum: b0474; MultiFun: Metabolism 1.5.2.3, 1.7.33; adenylate kinase; ATP-AMP transphosphorylase 367270..367923 Candidatus Blochmannia pennsylvanicus str. BPEN 3562587 YP_277815.1 CDS lpxH NC_007292.1 368807 369559 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(368807..369559) Candidatus Blochmannia pennsylvanicus str. BPEN 3562588 YP_277816.1 CDS cysS NC_007292.1 369936 371357 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 369936..371357 Candidatus Blochmannia pennsylvanicus str. BPEN 3562589 YP_277817.1 CDS folD NC_007292.1 371401 372261 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(371401..372261) Candidatus Blochmannia pennsylvanicus str. BPEN 3562590 YP_277818.1 CDS ytfF NC_007292.1 372689 373630 D ortholog to Escherichia coli bnum: b4210; MultiFun: Transport 4, 4.S.12; cationic amino acid transport protein 372689..373630 Candidatus Blochmannia pennsylvanicus str. BPEN 3562827 YP_277819.1 CDS mrdB NC_007292.1 374085 375197 R ortholog to Escherichia coli bnum: b0634; MultiFun: Cell processes 5.1; Cell structure 6.1; Transport 4.9.B.3; rod shape-determining protein complement(374085..375197) Candidatus Blochmannia pennsylvanicus str. BPEN 3562828 YP_277820.1 CDS mrdA NC_007292.1 375262 377112 R ortholog to Escherichia coli bnum: b0635; MultiFun: Cell processes 5.1, 5.6.4; Cell structure 6.2; Metabolism 1.6.7; peptidoglycan synthetase; cell elongation-specific transpeptidase of penicillin-binding protein 2 complement(375262..377112) Candidatus Blochmannia pennsylvanicus str. BPEN 3562829 YP_277821.1 CDS ybeB NC_007292.1 377234 377551 R ortholog to Escherichia coli bnum: b0637; hypothetical protein complement(377234..377551) Candidatus Blochmannia pennsylvanicus str. BPEN 3562830 YP_277822.1 CDS holA NC_007292.1 378161 379189 R ortholog to Escherichia coli bnum: b0640; MultiFun: Information transfer 2.1.1; DNA polymerase III subunit delta complement(378161..379189) Candidatus Blochmannia pennsylvanicus str. BPEN 3562831 YP_277823.1 CDS rlpB NC_007292.1 379255 379818 R ortholog to Escherichia coli bnum: b0641; MultiFun: Metabolism 1.6.10; rare lipoprotein B complement(379255..379818) Candidatus Blochmannia pennsylvanicus str. BPEN 3562832 YP_277824.1 CDS leuS NC_007292.1 379823 382441 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(379823..382441) Candidatus Blochmannia pennsylvanicus str. BPEN 3562833 YP_277825.1 CDS lnt NC_007292.1 382717 384249 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(382717..384249) Candidatus Blochmannia pennsylvanicus str. BPEN 3562834 YP_277826.1 CDS ybeX NC_007292.1 384252 385136 R ortholog to Escherichia coli bnum: b0658; MultiFun: Cell structure 6.1; hypothetical protein complement(384252..385136) Candidatus Blochmannia pennsylvanicus str. BPEN 3562835 YP_277827.1 CDS ybeY NC_007292.1 385169 385642 R ortholog to Escherichia coli bnum: b0659; hypothetical protein complement(385169..385642) Candidatus Blochmannia pennsylvanicus str. BPEN 3562836 YP_277828.1 CDS phoL NC_007292.1 385753 386745 R ortholog to Escherichia coli bnum: b0660; MultiFun: Transport 4.9.B; ATP-binding protein complement(385753..386745) Candidatus Blochmannia pennsylvanicus str. BPEN 3562837 YP_277829.1 CDS ubiF NC_007292.1 387214 388384 D ortholog to E. coli bnum: b0662; in-frame premature UAA termination codon is located within the ubiF sequence, and a +1 frameshift would be required for synthesis of ubiF; RNA polymerase or ribosomal slippage; possible young pseudogene; MultiFun: Metabolism 1.3.6, 1.5.3.11; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase join(387214..387348,387350..388384) Candidatus Blochmannia pennsylvanicus str. BPEN 3562838 YP_277830.1 CDS nagA NC_007292.1 389409 390569 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(389409..390569) Candidatus Blochmannia pennsylvanicus str. BPEN 3563056 YP_277831.1 CDS nagB NC_007292.1 390580 391383 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(390580..391383) Candidatus Blochmannia pennsylvanicus str. BPEN 3563057 YP_277832.1 CDS glnS NC_007292.1 392299 393957 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 392299..393957 Candidatus Blochmannia pennsylvanicus str. BPEN 3563058 YP_277833.1 CDS fldA NC_007292.1 394115 394642 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(394115..394642) Candidatus Blochmannia pennsylvanicus str. BPEN 3563059 YP_277834.1 CDS ybfF NC_007292.1 394862 395626 R ortholog to Escherichia coli bnum: b0686; alpha/beta hydrolase complement(394862..395626) Candidatus Blochmannia pennsylvanicus str. BPEN 3563060 YP_277835.1 CDS pgm NC_007292.1 395951 397609 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 395951..397609 Candidatus Blochmannia pennsylvanicus str. BPEN 3563061 YP_277836.1 CDS BPEN_336 NC_007292.1 398327 398470 R NT02BF0313; hypothetical protein complement(398327..398470) Candidatus Blochmannia pennsylvanicus str. BPEN 3563062 YP_277837.1 CDS sdhC NC_007292.1 399359 399766 D ortholog to Escherichia coli bnum: b0721; MultiFun: Cell structure 6.1; Metabolism 1.3.4, 1.3.6, 1.4.1, 1.4.3, 1.6.15.1; succinate dehydrogenase cytochrome b-556 subunit 399359..399766 Candidatus Blochmannia pennsylvanicus str. BPEN 3563063 YP_277838.1 CDS sdhD NC_007292.1 399742 400089 D ortholog to Escherichia coli bnum: b0722; MultiFun: Cell structure 6.1; Metabolism 1.3.4, 1.3.6, 1.4.1; succinate dehydrogenase hydrophobic membrane anchor protein 399742..400089 Candidatus Blochmannia pennsylvanicus str. BPEN 3562679 YP_277839.1 CDS sdhA NC_007292.1 400090 401874 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 400090..401874 Candidatus Blochmannia pennsylvanicus str. BPEN 3562680 YP_277840.1 CDS sdhB NC_007292.1 401891 402637 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 401891..402637 Candidatus Blochmannia pennsylvanicus str. BPEN 3562681 YP_277841.1 CDS sucA NC_007292.1 402838 405699 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 402838..405699 Candidatus Blochmannia pennsylvanicus str. BPEN 3562682 YP_277842.1 CDS sucB NC_007292.1 405720 406964 D ortholog to Escherichia coli bnum: b0727; MultiFun: Metabolism 1.3.4; dihydrolipoamide succinyltransferase E2 component 405720..406964 Candidatus Blochmannia pennsylvanicus str. BPEN 3562683 YP_277843.1 CDS sucC NC_007292.1 407081 408256 D ortholog to Escherichia coli bnum: b0728; MultiFun: Metabolism 1.3.4; succinyl-CoA synthetase subunit beta 407081..408256 Candidatus Blochmannia pennsylvanicus str. BPEN 3562684 YP_277844.1 CDS sucD NC_007292.1 408240 409121 D ortholog to Escherichia coli bnum: b0729; MultiFun: Metabolism 1.3.4; succinyl-CoA synthetase subunit alpha 408240..409121 Candidatus Blochmannia pennsylvanicus str. BPEN 3562685 YP_277845.1 CDS tolQ NC_007292.1 409499 410248 D inner membrane protein required for outer membrane integrity, uptake of group A colicins and phage DNA; ortholog to Escherichia coli bnum: b0737; MultiFun: Cell structure 6.1; hypothetical protein 409499..410248 Candidatus Blochmannia pennsylvanicus str. BPEN 3562686 YP_277846.1 CDS tolR NC_007292.1 410217 410642 D role in outer membrane integrity, uptake of group A colicins (TonB-independent), and phage DNA; ortholog to Escherichia coli bnum: b0738; MultiFun: Cell structure 6.1; hypothetical protein 410217..410642 Candidatus Blochmannia pennsylvanicus str. BPEN 3562687 YP_277847.1 CDS tolA NC_007292.1 410688 411872 D required for outer membrane integrity, uptake of group A colicins, role in translocation of filamenous phage DNA to cytoplasm, role in surface expression of O-antigen; ortholog to Escherichia coli bnum: b0739; MultiFun: Cell structure 6.1; Metabolism 1.6.3.1; hypothetical protein 410688..411872 Candidatus Blochmannia pennsylvanicus str. BPEN 3562688 YP_277848.1 CDS tolB NC_007292.1 411950 413311 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 411950..413311 Candidatus Blochmannia pennsylvanicus str. BPEN 3562756 YP_277849.1 CDS pal NC_007292.1 413371 413898 D required for outer membrane integrity, uptake of group A colicins, and translocation of phage DNA; ortholog to Escherichia coli bnum: b0741; MultiFun: Cell structure 6.1; hypothetical protein 413371..413898 Candidatus Blochmannia pennsylvanicus str. BPEN 3562757 YP_277850.1 CDS ybgF NC_007292.1 413906 414691 D contains a protein prenylyltransferase domain; ortholog to Escherichia coli bnum: b0742; hypothetical protein 413906..414691 Candidatus Blochmannia pennsylvanicus str. BPEN 3562807 YP_277851.1 CDS ybhE NC_007292.1 415746 416759 R catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase complement(415746..416759) Candidatus Blochmannia pennsylvanicus str. BPEN 3562808 YP_277852.1 CDS gpmA NC_007292.1 417047 417745 D ortholog to Escherichia coli bnum: b0755; MultiFun: Metabolism 1.1.1.23, 1.3.1, 1.7.8; phosphoglycerate mutase 417047..417745 Candidatus Blochmannia pennsylvanicus str. BPEN 3562809 YP_277853.1 CDS ybhL NC_007292.1 417934 418644 D ortholog to Escherichia coli bnum: b0786; MultiFun: Cell structure 6.1; Transport 4; transport protein 417934..418644 Candidatus Blochmannia pennsylvanicus str. BPEN 3562810 YP_277854.1 CDS ychF NC_007292.1 418754 419830 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(418754..419830) Candidatus Blochmannia pennsylvanicus str. BPEN 3562811 YP_277855.1 CDS pth NC_007292.1 419924 420517 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(419924..420517) Candidatus Blochmannia pennsylvanicus str. BPEN 3562812 YP_277856.1 CDS prsA NC_007292.1 420762 421700 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(420762..421700) Candidatus Blochmannia pennsylvanicus str. BPEN 3562813 YP_277857.1 CDS ispE NC_007292.1 421786 422673 R ortholog to Escherichia coli bnum: b1208; MultiFun: Metabolism 1.5.3.19; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(421786..422673) Candidatus Blochmannia pennsylvanicus str. BPEN 3562814 YP_277858.1 CDS lolB NC_007292.1 422670 423287 R ortholog to Escherichia coli bnum: b1209; MultiFun: Cell structure 6.1; outer membrane lipoprotein complement(422670..423287) Candidatus Blochmannia pennsylvanicus str. BPEN 3562815 YP_277859.1 CDS prfA NC_007292.1 423967 425049 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 423967..425049 Candidatus Blochmannia pennsylvanicus str. BPEN 3563033 YP_277860.1 CDS hemK NC_007292.1 425049 425885 D modifies release factors RF-1 and RF-2; ortholog to Escherichia coli bnum: b1212; MultiFun: Information transfer 2.3.2, 2.3.3; Regulation 3.1.3.2; N5-glutamine methyltransferase 425049..425885 Candidatus Blochmannia pennsylvanicus str. BPEN 3563034 YP_277861.1 CDS kdsA NC_007292.1 426212 427045 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 426212..427045 Candidatus Blochmannia pennsylvanicus str. BPEN 3563035 YP_277862.1 CDS thrS NC_007292.1 429232 430458 D ortholog to Escherichia coli bnum: b1719; MultiFun: Information transfer 2.3.1; threonyl-tRNA synthetase 429232..430458 Candidatus Blochmannia pennsylvanicus str. BPEN 3563036 YP_277863.1 CDS infC NC_007292.1 430465 431004 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 430465..431004 Candidatus Blochmannia pennsylvanicus str. BPEN 3563037 YP_277864.1 CDS rpmI NC_007292.1 431067 431264 D ortholog to Escherichia coli bnum: b1717; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L35 431067..431264 Candidatus Blochmannia pennsylvanicus str. BPEN 3563038 YP_277865.1 CDS rplT NC_007292.1 431338 431700 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 431338..431700 Candidatus Blochmannia pennsylvanicus str. BPEN 3563039 YP_277866.1 CDS pheS NC_007292.1 431885 432880 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 431885..432880 Candidatus Blochmannia pennsylvanicus str. BPEN 3563040 YP_277867.1 CDS pheT NC_007292.1 432894 435287 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 432894..435287 Candidatus Blochmannia pennsylvanicus str. BPEN 3563041 YP_277868.1 CDS lplA NC_007292.1 435873 436892 D ortholog to Escherichia coli bnum: b4386; MultiFun: Information transfer 2.3.1; Metabolism 1.6.10; lipoate-protein ligase A 435873..436892 Candidatus Blochmannia pennsylvanicus str. BPEN 3563042 YP_277869.1 CDS sufA NC_007292.1 437376 437756 D ortholog to Escherichia coli bnum: b1684; MultiFun: Metabolism 1.7.19; Fe-S cluster assembly protein 437376..437756 Candidatus Blochmannia pennsylvanicus str. BPEN 3562968 YP_277870.1 CDS sufB NC_007292.1 437771 439267 D with SufCD activates cysteine desulfurase SufS; cysteine desulfurase 437771..439267 Candidatus Blochmannia pennsylvanicus str. BPEN 3562969 YP_277871.1 CDS sufC NC_007292.1 439324 440064 D ortholog to Escherichia coli bnum: b1682; MultiFun: Transport 4.3.A.1.a; Fe-S cluster assembly ABC transporter ATP-binding protein 439324..440064 Candidatus Blochmannia pennsylvanicus str. BPEN 3562970 YP_277872.1 CDS sufD NC_007292.1 440045 441334 D with SufBC activates cysteine desulfurase SufS; cysteine desulfurase 440045..441334 Candidatus Blochmannia pennsylvanicus str. BPEN 3562971 YP_277873.1 CDS sufS NC_007292.1 441331 442557 D ortholog to Escherichia coli bnum: b1680; MultiFun: Metabolism 1.7.19; selenocysteine lyase 441331..442557 Candidatus Blochmannia pennsylvanicus str. BPEN 3562972 YP_277874.1 CDS sufE NC_007292.1 442576 443004 D ortholog to Escherichia coli bnum: b1679; MultiFun: Regulation 3.1.3; SufE Fe/S-cluster-like protein 442576..443004 Candidatus Blochmannia pennsylvanicus str. BPEN 3562973 YP_277875.1 CDS lpp NC_007292.1 443123 443359 R ortholog to Escherichia coli bnum: b1677; MultiFun: Cell structure 6.1, 6.2; Metabolism 1.6.7; murein lipoprotein complement(443123..443359) Candidatus Blochmannia pennsylvanicus str. BPEN 3562974 YP_277876.1 CDS ribE NC_007292.1 444000 444623 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 444000..444623 Candidatus Blochmannia pennsylvanicus str. BPEN 3562976 YP_277877.1 CDS ydhD NC_007292.1 444788 445120 D ortholog to Escherichia coli bnum: b1654; hypothetical protein 444788..445120 Candidatus Blochmannia pennsylvanicus str. BPEN 3562977 YP_277878.1 CDS rnt NC_007292.1 445293 445946 R Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T complement(445293..445946) Candidatus Blochmannia pennsylvanicus str. BPEN 3562978 YP_277879.1 CDS slyA NC_007292.1 446720 447154 D Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 446720..447154 Candidatus Blochmannia pennsylvanicus str. BPEN 3562645 YP_277880.1 CDS pdxH NC_007292.1 447480 448130 D ortholog to Escherichia coli bnum: b1638; MultiFun: Metabolism 1.5.3.6, 1.7.27; pyridoxamine 5'-phosphate oxidase 447480..448130 Candidatus Blochmannia pennsylvanicus str. BPEN 3562646 YP_277881.1 CDS tyrS NC_007292.1 448260 449543 D ortholog to Escherichia coli bnum: b1637; MultiFun: Information transfer 2.3.1; tyrosyl-tRNA synthetase 448260..449543 Candidatus Blochmannia pennsylvanicus str. BPEN 3562647 YP_277882.1 CDS nth NC_007292.1 449664 450305 R ortholog to Escherichia coli bnum: b1633; MultiFun: Cell processes 5.6.1; Information transfer 2.1.5; Metabolism 1.2.2; endonuclease III complement(449664..450305) Candidatus Blochmannia pennsylvanicus str. BPEN 3562648 YP_277883.1 CDS fumC NC_007292.1 450402 451802 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(450402..451802) Candidatus Blochmannia pennsylvanicus str. BPEN 3562649 YP_277884.1 CDS eaeH NC_007292.1 452045 454054 D ortholog to Escherichia coli bnum: b0297; MultiFun: Cell structure 6.1; adhesin 452045..454054 Candidatus Blochmannia pennsylvanicus str. BPEN 3562650 YP_277885.1 CDS ubiX NC_007292.1 454174 454788 R ortholog to Escherichia coli bnum: b2311; MultiFun: Metabolism 1.3.6, 1.5.3.11; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(454174..454788) Candidatus Blochmannia pennsylvanicus str. BPEN 3562651 YP_277886.1 CDS kdsB NC_007292.1 455118 455906 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(455118..455906) Candidatus Blochmannia pennsylvanicus str. BPEN 3562652 YP_277887.1 CDS ycaR NC_007292.1 455918 456085 R ortholog to Escherichia coli bnum: b0917; hypothetical protein complement(455918..456085) Candidatus Blochmannia pennsylvanicus str. BPEN 3562653 YP_277888.1 CDS lpxK NC_007292.1 456296 457309 R transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase complement(456296..457309) Candidatus Blochmannia pennsylvanicus str. BPEN 3562654 YP_277889.1 CDS msbA NC_007292.1 457309 459063 R involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease complement(457309..459063) Candidatus Blochmannia pennsylvanicus str. BPEN 3562655 YP_277890.1 CDS rpsA NC_007292.1 459768 461462 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(459768..461462) Candidatus Blochmannia pennsylvanicus str. BPEN 3562897 YP_277891.1 CDS cmk NC_007292.1 461537 462256 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(461537..462256) Candidatus Blochmannia pennsylvanicus str. BPEN 3562898 YP_277892.1 CDS aroA NC_007292.1 462385 463683 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(462385..463683) Candidatus Blochmannia pennsylvanicus str. BPEN 3562758 YP_277893.1 CDS serC NC_007292.1 463815 464903 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(463815..464903) Candidatus Blochmannia pennsylvanicus str. BPEN 3562759 YP_277894.1 CDS serS NC_007292.1 465241 466527 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(465241..466527) Candidatus Blochmannia pennsylvanicus str. BPEN 3562760 YP_277895.1 CDS lolA NC_007292.1 467312 467929 R periplasmic chaperone effects translocation of lipoproteins from inner membrane to outer membrane; ortholog to Escherichia coli bnum: b0891; MultiFun: Information transfer 2.3.4; Transport 4.9.B, 4.S.106; LolA protein complement(467312..467929) Candidatus Blochmannia pennsylvanicus str. BPEN 3562761 YP_277896.1 CDS ftsK NC_007292.1 468047 470428 R ortholog to Escherichia coli bnum: b0890; MultiFun: Cell processes 5.1, 5.8; Cell structure 6.1; Transport 4.9.A.16; cell division protein complement(468047..470428) Candidatus Blochmannia pennsylvanicus str. BPEN 3562762 YP_277897.1 CDS trxB NC_007292.1 471064 472020 D ortholog to Escherichia coli bnum: b0888; MultiFun: Metabolism 1.7.1; thioredoxin reductase 471064..472020 Candidatus Blochmannia pennsylvanicus str. BPEN 3562763 YP_277898.1 CDS infA NC_007292.1 472511 472729 D ortholog to Escherichia coli bnum: b0884; MultiFun: Information transfer 2.3.2; translation initiation factor IF-1 472511..472729 Candidatus Blochmannia pennsylvanicus str. BPEN 3562764 YP_277899.1 CDS oprC NC_007292.1 472885 475041 R outer membrane protein; protein OprC complement(472885..475041) Candidatus Blochmannia pennsylvanicus str. BPEN 3562765 YP_277900.1 CDS yqeI NC_007292.1 475612 476250 D ortholog to Escherichia coli bnum: b2847; transcriptional regulator 475612..476250 Candidatus Blochmannia pennsylvanicus str. BPEN 3562766 YP_277901.1 CDS emtA NC_007292.1 477175 477819 R ortholog to Escherichia coli bnum: b1193; MultiFun: Cell structure 6.1, 6.2; Metabolism 1.6.7; membrane-bound lytic murein transglycosylase E complement(477175..477819) Candidatus Blochmannia pennsylvanicus str. BPEN 3562633 YP_277902.1 CDS mntR NC_007292.1 478280 478741 R Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR complement(478280..478741) Candidatus Blochmannia pennsylvanicus str. BPEN 3562634 YP_277903.1 CDS mnmA NC_007292.1 479466 480569 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 479466..480569 Candidatus Blochmannia pennsylvanicus str. BPEN 3562635 YP_277904.1 CDS purB NC_007292.1 480986 482368 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 480986..482368 Candidatus Blochmannia pennsylvanicus str. BPEN 3562636 YP_277905.1 CDS lolE NC_007292.1 482601 483836 R ortholog to Escherichia coli bnum: b1118; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.106; outer membrane lipoproteins ABC transporter membrane protein complement(482601..483836) Candidatus Blochmannia pennsylvanicus str. BPEN 3562637 YP_277906.1 CDS lolD NC_007292.1 483847 484548 R ortholog to Escherichia coli bnum: b1117; MultiFun: Transport 4.3.A.1.a, 4.S.106; outer membrane lipoproteins ABC transporter ATP-binding protein complement(483847..484548) Candidatus Blochmannia pennsylvanicus str. BPEN 3562638 YP_277907.1 CDS lolC NC_007292.1 484541 485746 R ortholog to Escherichia coli bnum: b1116; MultiFun: Cell structure 6.1; Transport 4.3.A.1.m, 4.S.106; outer membrane lipoproteins ABC transporter membrane protein complement(484541..485746) Candidatus Blochmannia pennsylvanicus str. BPEN 3562639 YP_277908.1 CDS ycfM NC_007292.1 485989 486525 R ortholog to Escherichia coli bnum: b1105; fibronectin-binding protein complement(485989..486525) Candidatus Blochmannia pennsylvanicus str. BPEN 3562640 YP_277909.1 CDS ycfF NC_007292.1 486715 487065 R ortholog to Escherichia coli bnum: b1103; MultiFun: Information transfer 2.3; protein kinase C inhibitor complement(486715..487065) Candidatus Blochmannia pennsylvanicus str. BPEN 3562641 YP_277910.1 CDS ycfH NC_007292.1 487339 488124 R ortholog to Escherichia coli bnum: b1100; metallo-dependent hydrolase complement(487339..488124) Candidatus Blochmannia pennsylvanicus str. BPEN 3562642 YP_277911.1 CDS holB NC_007292.1 488141 489142 R ortholog to Escherichia coli bnum: b1099; MultiFun: Information transfer 2.1.1; DNA polymerase III, delta prime subunit complement(488141..489142) Candidatus Blochmannia pennsylvanicus str. BPEN 3562643 YP_277912.1 CDS tmk NC_007292.1 489149 489787 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(489149..489787) Candidatus Blochmannia pennsylvanicus str. BPEN 3562644 YP_277913.1 CDS pabC NC_007292.1 490159 490980 R ortholog to Escherichia coli bnum: b1096; MultiFun: Metabolism 1.5.3.2; 4-amino-4-deoxychorismate lyase complement(490159..490980) Candidatus Blochmannia pennsylvanicus str. BPEN 3562689 YP_277914.1 CDS acpP NC_007292.1 491600 491851 R ortholog to Escherichia coli bnum: b1094; MultiFun: Metabolism 1.6.15.4; acyl carrier protein complement(491600..491851) Candidatus Blochmannia pennsylvanicus str. BPEN 3562690 YP_277915.1 CDS fabG NC_007292.1 491980 492714 R ortholog to Escherichia coli bnum: b1093; MultiFun: Metabolism 1.5.4; 3-oxoacyl-ACP reductase complement(491980..492714) Candidatus Blochmannia pennsylvanicus str. BPEN 3562691 YP_277916.1 CDS fabD NC_007292.1 492744 493685 R ortholog to Escherichia coli bnum: b1092; MultiFun: Metabolism 1.5.4; malonyl CoA-ACP transacylase complement(492744..493685) Candidatus Blochmannia pennsylvanicus str. BPEN 3562692 YP_277917.1 CDS fabH NC_007292.1 493709 494662 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(493709..494662) Candidatus Blochmannia pennsylvanicus str. BPEN 3562693 YP_277918.1 CDS plsX NC_007292.1 494668 495696 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX complement(494668..495696) Candidatus Blochmannia pennsylvanicus str. BPEN 3562694 YP_277919.1 CDS rpmF NC_007292.1 495727 495897 R ortholog to Escherichia coli bnum: b1089; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L32 complement(495727..495897) Candidatus Blochmannia pennsylvanicus str. BPEN 3562695 YP_277920.1 CDS rluC NC_007292.1 496794 497810 R ortholog to Escherichia coli bnum: b1086; MultiFun: Information transfer 2.2.3; ribosomal large subunit (23S) pseudouridine synthase C complement(496794..497810) Candidatus Blochmannia pennsylvanicus str. BPEN 3562696 YP_277921.1 CDS rne NC_007292.1 498327 500927 D ortholog to Escherichia coli bnum: b1084; MultiFun: Information transfer 2.2.4; Metabolism 1.2.1; ribonuclease E 498327..500927 Candidatus Blochmannia pennsylvanicus str. BPEN 3562697 YP_277922.1 CDS lpxL NC_007292.1 501333 502256 D ortholog to Escherichia coli bnum: b1054; MultiFun: Cell structure 6.1; Cell structure 6.3; Metabolism 1.6.3.3; lipid A biosynthesis lauroyl acyltransferase 501333..502256 Candidatus Blochmannia pennsylvanicus str. BPEN 3562698 YP_277923.1 CDS ybiS NC_007292.1 502631 503579 D ortholog to E. coli bnum: b0819; in-frame premature UAG termination codon is located within the ybiS sequence, and a +1 frameshift would be required for synthesis of ybiS; RNA polymerase or ribosomal slippage; possible young pseudogene; hypothetical protein join(502631..503071,503073..503579) Candidatus Blochmannia pennsylvanicus str. BPEN 3562699 YP_277924.1 CDS pgsA NC_007292.1 504315 504866 R ortholog to Escherichia coli bnum: b1912; MultiFun: Cell structure 6.1; Metabolism 1.6.1; phosphotidylglycerophosphate synthetase complement(504315..504866) Candidatus Blochmannia pennsylvanicus str. BPEN 3562737 YP_277925.1 CDS yccK NC_007292.1 506144 506473 D ortholog to Escherichia coli bnum: b0969; sulfite reductase 506144..506473 Candidatus Blochmannia pennsylvanicus str. BPEN 3562740 YP_277926.1 CDS yccV NC_007292.1 506681 506998 D ortholog to Escherichia coli bnum: b0966; heat shock protein HspQ 506681..506998 Candidatus Blochmannia pennsylvanicus str. BPEN 3562741 YP_277927.1 CDS fabA NC_007292.1 507833 508351 D catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 507833..508351 Candidatus Blochmannia pennsylvanicus str. BPEN 3562742 YP_277928.1 CDS asnC NC_007292.1 508697 510109 D catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 508697..510109 Candidatus Blochmannia pennsylvanicus str. BPEN 3562743 YP_277929.1 CDS aspC NC_007292.1 510328 511533 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 510328..511533 Candidatus Blochmannia pennsylvanicus str. BPEN 3562744 YP_277930.1 CDS ycbL NC_007292.1 511701 512354 R ortholog to Escherichia coli bnum: b0927; metallo-hydrolase/oxidoreductase domain-containing protein complement(511701..512354) Candidatus Blochmannia pennsylvanicus str. BPEN 3562745 YP_277931.1 CDS fabI NC_007292.1 512610 513398 R ortholog to Escherichia coli bnum: b1288; MultiFun: Metabolism 1.5.4; enoyl-ACP reductase complement(512610..513398) Candidatus Blochmannia pennsylvanicus str. BPEN 3562816 YP_277932.1 CDS ribA NC_007292.1 515202 515801 D catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 515202..515801 Candidatus Blochmannia pennsylvanicus str. BPEN 3562817 YP_277933.1 CDS trpE NC_007292.1 518841 520403 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 518841..520403 Candidatus Blochmannia pennsylvanicus str. BPEN 3562818 YP_277934.1 CDS trpG NC_007292.1 520406 521002 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 520406..521002 Candidatus Blochmannia pennsylvanicus str. BPEN 3562819 YP_277935.1 CDS trpD NC_007292.1 521004 522029 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 521004..522029 Candidatus Blochmannia pennsylvanicus str. BPEN 3562820 YP_277936.1 CDS trpC NC_007292.1 522007 523380 D monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 522007..523380 Candidatus Blochmannia pennsylvanicus str. BPEN 3562821 YP_277937.1 CDS trpB NC_007292.1 523423 524613 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 523423..524613 Candidatus Blochmannia pennsylvanicus str. BPEN 3562822 YP_277938.1 CDS trpA NC_007292.1 524616 525446 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 524616..525446 Candidatus Blochmannia pennsylvanicus str. BPEN 3562823 YP_277939.1 CDS yciC NC_007292.1 525901 526638 D ortholog to Escherichia coli bnum: b1255; MultiFun: Cell structure 6.1; hypothetical protein 525901..526638 Candidatus Blochmannia pennsylvanicus str. BPEN 3562824 YP_277940.1 CDS tonB NC_007292.1 526804 527532 R ortholog to Escherichia coli bnum: b1252; MultiFun: Cell structure 6.1; energy transducer complement(526804..527532) Candidatus Blochmannia pennsylvanicus str. BPEN 3562825 YP_277941.1 CDS cls NC_007292.1 528045 529514 D catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 528045..529514 Candidatus Blochmannia pennsylvanicus str. BPEN 3562826 YP_277942.1 CDS tdk NC_007292.1 529960 530577 R catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase complement(529960..530577) Candidatus Blochmannia pennsylvanicus str. BPEN 3562656 YP_277943.1 CDS hns NC_007292.1 531205 531615 D ortholog to Escherichia coli bnum: b1237; MultiFun: Cell processes 5.3; Cell structure 6.4; Information transfer 2.2.2, 2.3.7; Regulation 3.1.2; global DNA-binding transcriptional dual regulator H-NS 531205..531615 Candidatus Blochmannia pennsylvanicus str. BPEN 3562657 YP_277944.1 CDS xthA NC_007292.1 533574 534380 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 533574..534380 Candidatus Blochmannia pennsylvanicus str. BPEN 3562658 YP_277945.1 CDS sppA NC_007292.1 534585 536462 D signal peptide peptidase; ortholog to Escherichia coli bnum: b1766; MultiFun: Metabolism 1.2.3; endopeptidase IV 534585..536462 Candidatus Blochmannia pennsylvanicus str. BPEN 3562659 YP_277946.1 CDS gapA NC_007292.1 536840 537838 D ortholog to Escherichia coli bnum: b1779; MultiFun: Metabolism 1.1.1.23, 1.3.1, 1.5.3.6, 1.7.8; glyceraldehyde 3-phosphate dehydrogenase A 536840..537838 Candidatus Blochmannia pennsylvanicus str. BPEN 3562660 YP_277947.1 CDS dsbB NC_007292.1 538357 538881 D disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 538357..538881 Candidatus Blochmannia pennsylvanicus str. BPEN 3562661 YP_277948.1 CDS minC NC_007292.1 539585 540265 D cell division inhibitor; septum site determining protein; ortholog to Escherichia coli bnum: b1176; MultiFun: Cell processes 5.1; hypothetical protein 539585..540265 Candidatus Blochmannia pennsylvanicus str. BPEN 3562662 YP_277949.1 CDS minD NC_007292.1 540291 541103 D cell division inhibitor; septum site determining protein; ortholog to Escherichia coli bnum: b1175; MultiFun: Cell processes 5.1; Cell structure 6.1; hypothetical protein 540291..541103 Candidatus Blochmannia pennsylvanicus str. BPEN 3562663 YP_277950.1 CDS minE NC_007292.1 541111 541374 D ortholog to Escherichia coli bnum: b1174; MultiFun: Cell processes 5.1; cell division topological specificity factor 541111..541374 Candidatus Blochmannia pennsylvanicus str. BPEN 3562664 YP_277951.1 CDS yeaZ NC_007292.1 541729 542448 R ortholog to Escherichia coli bnum: b1807; MultiFun: Metabolism 1.2.3; glycoprotein endopeptidase actin-like ATPase domain complement(541729..542448) Candidatus Blochmannia pennsylvanicus str. BPEN 3562665 YP_277952.1 CDS pabB NC_007292.1 542815 544203 D component of p-aminobenzoate synthase multienzyme complex; ortholog to Escherichia coli bnum: b1812; MultiFun: Metabolism 1.5.3.2; aminodeoxychorismate synthase subunit I 542815..544203 Candidatus Blochmannia pennsylvanicus str. BPEN 3562666 YP_277953.1 CDS yoaE NC_007292.1 544268 545824 R ortholog to Escherichia coli bnum: b1816; MultiFun: Cell structure 6.1; transmembrane protein complement(544268..545824) Candidatus Blochmannia pennsylvanicus str. BPEN 3563159 YP_277954.1 CDS manX NC_007292.1 546359 547342 D ortholog to Escherichia coli bnum: b1817; MultiFun: Metabolism 1.1.1; Transport 4.4.A.6, 4.S.116; PTS family enzyme IIA/enzyme IIB, mannose-specific 546359..547342 Candidatus Blochmannia pennsylvanicus str. BPEN 3562955 YP_277955.1 CDS manY NC_007292.1 547418 548227 D ortholog to Escherichia coli bnum: b1818; MultiFun: Cell structure 6.1; Metabolism 1.1.1; Transport 4.4.A.6, 4.S.116; PTS family enzyme IIC, mannose-specific 547418..548227 Candidatus Blochmannia pennsylvanicus str. BPEN 3562956 YP_277956.1 CDS manZ NC_007292.1 548254 549120 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 548254..549120 Candidatus Blochmannia pennsylvanicus str. BPEN 3562957 YP_277957.1 CDS cspC NC_007292.1 549452 549661 R ortholog to Escherichia coli bnum: b1823; MultiFun: Cell processes 5.5.2; Information transfer 2.2.2; Regulation 3.1.2.2; cold shock-like protein CspC complement(549452..549661) Candidatus Blochmannia pennsylvanicus str. BPEN 3562958 YP_277958.1 CDS htpX NC_007292.1 550270 551205 R metalloprotease; heat shock protein HtpX complement(550270..551205) Candidatus Blochmannia pennsylvanicus str. BPEN 3562959 YP_277959.1 CDS zwf NC_007292.1 551437 552921 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(551437..552921) Candidatus Blochmannia pennsylvanicus str. BPEN 3562960 YP_277960.1 CDS pykA NC_007292.1 553587 555035 D ortholog to Escherichia coli bnum: b1854; MultiFun: Metabolism 1.1.1.23, 1.3.1, 1.3.5, 1.3.7; pyruvate kinase A 553587..555035 Candidatus Blochmannia pennsylvanicus str. BPEN 3562961 YP_277961.1 CDS yebA NC_007292.1 555204 556562 R ortholog to Escherichia coli bnum: b1856; hypothetical protein complement(555204..556562) Candidatus Blochmannia pennsylvanicus str. BPEN 3562962 YP_277962.1 CDS aspS NC_007292.1 556853 558577 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(556853..558577) Candidatus Blochmannia pennsylvanicus str. BPEN 3562963 YP_277963.1 CDS argS NC_007292.1 559209 560954 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 559209..560954 Candidatus Blochmannia pennsylvanicus str. BPEN 3562964 YP_277964.1 CDS mviN NC_007292.1 560978 562525 R ortholog to Escherichia coli bnum: b1069; MultiFun: Cell processes 5.1; Cell structure 6.1; virulence factor complement(560978..562525) Candidatus Blochmannia pennsylvanicus str. BPEN 3562965 YP_277965.1 CDS yceL NC_007292.1 563140 564363 D Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 563140..564363 Candidatus Blochmannia pennsylvanicus str. BPEN 3562966 YP_277966.1 CDS gutQ NC_007292.1 565638 566615 R catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase complement(565638..566615) Candidatus Blochmannia pennsylvanicus str. BPEN 3562981 YP_277967.1 CDS yeeX NC_007292.1 567109 567432 R ortholog to Escherichia coli bnum: b2007; hypothetical protein complement(567109..567432) Candidatus Blochmannia pennsylvanicus str. BPEN 3562982 YP_277968.1 CDS sbcB NC_007292.1 567703 569205 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 567703..569205 Candidatus Blochmannia pennsylvanicus str. BPEN 3562983 YP_277969.1 CDS hisG NC_007292.1 569725 570624 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 569725..570624 Candidatus Blochmannia pennsylvanicus str. BPEN 3562984 YP_277970.1 CDS hisD NC_007292.1 570629 571960 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 570629..571960 Candidatus Blochmannia pennsylvanicus str. BPEN 3562985 YP_277971.1 CDS hisC NC_007292.1 571938 573014 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 571938..573014 Candidatus Blochmannia pennsylvanicus str. BPEN 3562986 YP_277972.1 CDS hisB NC_007292.1 573031 574101 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 573031..574101 Candidatus Blochmannia pennsylvanicus str. BPEN 3562987 YP_277973.1 CDS hisH NC_007292.1 574098 574687 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH join(574098..574274,574274..574687) Candidatus Blochmannia pennsylvanicus str. BPEN 3562988 YP_277974.1 CDS hisA NC_007292.1 574691 575431 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 574691..575431 Candidatus Blochmannia pennsylvanicus str. BPEN 3562989 YP_277975.1 CDS hisF NC_007292.1 575413 576189 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 575413..576189 Candidatus Blochmannia pennsylvanicus str. BPEN 3562990 YP_277976.1 CDS hisI NC_007292.1 576183 576824 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 576183..576824 Candidatus Blochmannia pennsylvanicus str. BPEN 3562991 YP_277977.1 CDS gnd NC_007292.1 577078 578487 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(577078..578487) Candidatus Blochmannia pennsylvanicus str. BPEN 3562992 YP_277978.1 CDS metG NC_007292.1 579039 580706 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 579039..580706 Candidatus Blochmannia pennsylvanicus str. BPEN 3562993 YP_277979.1 CDS folE NC_007292.1 581657 582322 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(581657..582322) Candidatus Blochmannia pennsylvanicus str. BPEN 3562994 YP_277980.1 CDS rplY NC_007292.1 583227 583520 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 583227..583520 Candidatus Blochmannia pennsylvanicus str. BPEN 3562995 YP_277981.1 CDS ddl NC_007292.1 583897 585003 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(583897..585003) Candidatus Blochmannia pennsylvanicus str. BPEN 3562997 YP_277982.1 CDS omp NC_007292.1 585092 586213 R ortholog to Escherichia coli bnum: b2215; MultiFun: Cell structure 6.1; Transport 4.1.B.1, 4.S.92; hypothetical protein complement(585092..586213) Candidatus Blochmannia pennsylvanicus str. BPEN 3562998 YP_277983.1 CDS gyrA NC_007292.1 586917 589448 R ortholog to Escherichia coli bnum: b2231; MultiFun: Information transfer 2.1.1; Information transfer 2.2.2; Regulation 3.1.1.1; type II topoisomerase; DNA gyrase, subunit A complement(586917..589448) Candidatus Blochmannia pennsylvanicus str. BPEN 3562999 YP_277984.1 CDS ubiG NC_007292.1 589738 590430 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 589738..590430 Candidatus Blochmannia pennsylvanicus str. BPEN 3563000 YP_277985.1 CDS nrdA NC_007292.1 590814 593096 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 590814..593096 Candidatus Blochmannia pennsylvanicus str. BPEN 3563011 YP_277986.1 CDS nrdB NC_007292.1 593153 594283 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 593153..594283 Candidatus Blochmannia pennsylvanicus str. BPEN 3563012 YP_277987.1 CDS yfaE NC_007292.1 594258 594548 D ortholog to Escherichia coli bnum: b2236; hypothetical protein 594258..594548 Candidatus Blochmannia pennsylvanicus str. BPEN 3563013 YP_277988.1 CDS nuoN NC_007292.1 594648 596141 R ortholog to Escherichia coli bnum: b2276; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130; NADH dehydrogenase I subunit N, membrane subunit complement(594648..596141) Candidatus Blochmannia pennsylvanicus str. BPEN 3563014 YP_277989.1 CDS nuoM NC_007292.1 596175 597716 R ortholog to Escherichia coli bnum: b2277; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130; NADH dehydrogenase I subunit M, membrane subunit complement(596175..597716) Candidatus Blochmannia pennsylvanicus str. BPEN 3563015 YP_277990.1 CDS nuoL NC_007292.1 597800 599686 R ortholog to Escherichia coli bnum: b2278; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130; NADH dehydrogenase I subunit L, membrane subunit complement(597800..599686) Candidatus Blochmannia pennsylvanicus str. BPEN 3563016 YP_277991.1 CDS nuoK NC_007292.1 599683 599985 R ortholog to Escherichia coli bnum: b2279; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130; NADH dehydrogenase I subunit K complement(599683..599985) Candidatus Blochmannia pennsylvanicus str. BPEN 3563017 YP_277992.1 CDS nuoJ NC_007292.1 599982 600533 R ortholog to Escherichia coli bnum: b2280; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130; NADH dehydrogenase I subunit J complement(599982..600533) Candidatus Blochmannia pennsylvanicus str. BPEN 3563018 YP_277993.1 CDS nuoI NC_007292.1 600567 601112 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(600567..601112) Candidatus Blochmannia pennsylvanicus str. BPEN 3563019 YP_277994.1 CDS nuoH NC_007292.1 601137 602108 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(601137..602108) Candidatus Blochmannia pennsylvanicus str. BPEN 3563020 YP_277995.1 CDS nuoG NC_007292.1 602108 604867 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(602108..604867) Candidatus Blochmannia pennsylvanicus str. BPEN 3563021 YP_277996.1 CDS nuoF NC_007292.1 604984 606315 R ortholog to Escherichia coli bnum: b2284; MultiFun: Metabolism 1.3.6; Metabolism 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130; NADH dehydrogenase I subunit F complement(604984..606315) Candidatus Blochmannia pennsylvanicus str. BPEN 3563022 YP_277997.1 CDS nuoE NC_007292.1 606312 606833 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(606312..606833) Candidatus Blochmannia pennsylvanicus str. BPEN 3563023 YP_277998.1 CDS nuoCD NC_007292.1 606847 608637 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(606847..608637) Candidatus Blochmannia pennsylvanicus str. BPEN 3563024 YP_277999.1 CDS nuoB NC_007292.1 608675 609385 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(608675..609385) Candidatus Blochmannia pennsylvanicus str. BPEN 3563025 YP_278000.1 CDS nuoA NC_007292.1 609391 609831 R ortholog to Escherichia coli bnum: b2288; MultiFun: Cell structure 6.1; Metabolism 1.3.6, 1.3.7, 1.4.1; Transport 4.3.D.1, 4.S.130; NADH dehydrogenase I subunit A complement(609391..609831) Candidatus Blochmannia pennsylvanicus str. BPEN 3563026 YP_278001.1 CDS folC NC_007292.1 610496 611770 R bifunctional ortholog to Escherichia coli bnum: b2315; MultiFun: Metabolism 1.5.3.2, 1.7.17; folylpolyglutamate synthase; dihydrofolate synthase complement(610496..611770) Candidatus Blochmannia pennsylvanicus str. BPEN 3563027 YP_278002.1 CDS accD NC_007292.1 611837 612721 R ortholog to Escherichia coli bnum: b2316; MultiFun: Metabolism 1.5.4; acetyl-CoA carboxylase subunit beta complement(611837..612721) Candidatus Blochmannia pennsylvanicus str. BPEN 3563028 YP_278003.1 CDS truA NC_007292.1 613072 613857 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(613072..613857) Candidatus Blochmannia pennsylvanicus str. BPEN 3563029 YP_278004.1 CDS pdxB NC_007292.1 614374 615498 R ortholog to Escherichia coli bnum: b2320; MultiFun: Metabolism 1.5.3.6; erythronate-4-phosphate dehydrogenase complement(614374..615498) Candidatus Blochmannia pennsylvanicus str. BPEN 3563030 YP_278005.1 CDS fabB NC_007292.1 615721 616935 R ortholog to Escherichia coli bnum: b2323; MultiFun: Metabolism 1.5.4; 3-oxoacyl-ACP synthase complement(615721..616935) Candidatus Blochmannia pennsylvanicus str. BPEN 3563031 YP_278006.1 CDS yfcB NC_007292.1 617740 618654 D involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 617740..618654 Candidatus Blochmannia pennsylvanicus str. BPEN 3563032 YP_278007.1 CDS aroC NC_007292.1 618679 619743 D catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 618679..619743 Candidatus Blochmannia pennsylvanicus str. BPEN 3563141 YP_278008.1 CDS mntH NC_007292.1 620543 621778 R ortholog to Escherichia coli bnum: b2392; MultiFun: Cell processes 5.6.2; Cell structure 6.1; Transport 4.2.A.55, 4.S.123; manganese transport protein MntH complement(620543..621778) Candidatus Blochmannia pennsylvanicus str. BPEN 3563143 YP_278009.1 CDS nupC NC_007292.1 622114 623304 D ortholog to Escherichia coli bnum: b2393; MultiFun: Cell structure 6.1; Metabolism 1.7.33; Transport 4.2.A.41, 4.S.146; NupC family nucleoside transporter 622114..623304 Candidatus Blochmannia pennsylvanicus str. BPEN 3563144 YP_278010.1 CDS gltX NC_007292.1 623765 625171 R ortholog to Escherichia coli bnum: b2400; MultiFun: Information transfer 2.3.1; Metabolism 1.5.3.12; glutamate tRNA synthetase, catalytic subunit complement(623765..625171) Candidatus Blochmannia pennsylvanicus str. BPEN 3562945 YP_278011.1 CDS ligA NC_007292.1 625784 627571 R ortholog to Escherichia coli bnum: b2411; MultiFun: Information transfer 2.1.4; DNA ligase complement(625784..627571) Candidatus Blochmannia pennsylvanicus str. BPEN 3562951 YP_278012.1 CDS cysK NC_007292.1 627934 628881 D ortholog to Escherichia coli bnum: b2414; MultiFun: Metabolism 1.5.1.12; cysteine synthase A 627934..628881 Candidatus Blochmannia pennsylvanicus str. BPEN 3562952 YP_278013.1 CDS ptsH NC_007292.1 629267 629524 D ortholog to Escherichia coli bnum: b2415; MultiFun: Metabolism 1.1.1; Transport 4.8.A.8, 4.S.173; PTS family Hpr protein, phosphohistidinoprotein-hexose phosphotransferase 629267..629524 Candidatus Blochmannia pennsylvanicus str. BPEN 3562787 YP_278014.1 CDS ptsI NC_007292.1 629590 631323 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 629590..631323 Candidatus Blochmannia pennsylvanicus str. BPEN 3562788 YP_278015.1 CDS cysA NC_007292.1 631772 632839 R ortholog to Escherichia coli bnum: b2422; MultiFun: Cell processes 5.6.4; Metabolism 1.8.2, 4.3.A.1.a, 4.S.179; sulfate/thiosulfate transporter subunit complement(631772..632839) Candidatus Blochmannia pennsylvanicus str. BPEN 3562789 YP_278016.1 CDS cysW NC_007292.1 632861 633721 R ortholog to Escherichia coli bnum: b2423; MultiFun: Cell structure 6.1; Metabolism 1.8.2; Transport 4.3.A.1.m, 4.S.178; thiosulfate permease W complement(632861..633721) Candidatus Blochmannia pennsylvanicus str. BPEN 3562790 YP_278017.1 CDS cysU NC_007292.1 633721 634554 R ortholog to Escherichia coli bnum: b2424; MultiFun: Cell structure 6.1; Metabolism 1.8.2; Transport 4.3.A.1.m, 4.S.178; sulfate/thiosulfate transporter subunit complement(633721..634554) Candidatus Blochmannia pennsylvanicus str. BPEN 3562791 YP_278018.1 CDS cysP NC_007292.1 634554 635576 R ortholog to Escherichia coli bnum: b2425; MultiFun: Metabolism 1.8.2; Transport 4.3.A.1.p, 4.S.178; thiosulfate ABC transporter substrate-binding protein complement(634554..635576) Candidatus Blochmannia pennsylvanicus str. BPEN 3562792 YP_278019.1 CDS talA NC_007292.1 636778 637629 D ortholog to Escherichia coli bnum: b2464; MultiFun: Metabolism 1.7.3; transaldolase A 636778..637629 Candidatus Blochmannia pennsylvanicus str. BPEN 3562793 YP_278020.1 CDS tktA NC_007292.1 637742 639739 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 637742..639739 Candidatus Blochmannia pennsylvanicus str. BPEN 3562794 YP_278021.1 CDS dapE NC_007292.1 639918 641072 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 639918..641072 Candidatus Blochmannia pennsylvanicus str. BPEN 3562795 YP_278022.1 CDS BPEN_535 NC_007292.1 641232 641543 R hypothetical protein complement(641232..641543) Candidatus Blochmannia pennsylvanicus str. BPEN 3562796 YP_278023.1 CDS dapA NC_007292.1 641564 642463 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(641564..642463) Candidatus Blochmannia pennsylvanicus str. BPEN 3562873 YP_278024.1 CDS bcp NC_007292.1 642934 643419 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 642934..643419 Candidatus Blochmannia pennsylvanicus str. BPEN 3562874 YP_278025.1 CDS upp NC_007292.1 643556 644182 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(643556..644182) Candidatus Blochmannia pennsylvanicus str. BPEN 3562875 YP_278026.1 CDS BPEN_539 NC_007292.1 644913 645113 D hypothetical protein 644913..645113 Candidatus Blochmannia pennsylvanicus str. BPEN 3562876 YP_278027.1 CDS ureG NC_007292.1 645412 646035 R ortholog to Escherichia coli bnum: ECs1327; MultiFun: Metabolism1.1.4.4; urease accessory protein G complement(645412..646035) Candidatus Blochmannia pennsylvanicus str. BPEN 3562877 YP_278028.1 CDS ureF NC_007292.1 646116 646802 R ortholog to Escherichia coli bnum: ECs1326; MultiFun: Metabolism1.1.4.4; urease accessory protein F complement(646116..646802) Candidatus Blochmannia pennsylvanicus str. BPEN 3562878 YP_278029.1 CDS ureC NC_007292.1 647273 648976 R ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha complement(647273..648976) Candidatus Blochmannia pennsylvanicus str. BPEN 3562879 YP_278030.1 CDS ureB NC_007292.1 648979 649287 R ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta complement(648979..649287) Candidatus Blochmannia pennsylvanicus str. BPEN 3562880 YP_278031.1 CDS ureA NC_007292.1 649315 649617 R UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma complement(649315..649617) Candidatus Blochmannia pennsylvanicus str. BPEN 3562881 YP_278032.1 CDS ureD NC_007292.1 649631 650467 R ortholog to Escherichia coli bnum: ECs1321; MultiFun: Metabolism1.1.4.4; urease accessory protein D complement(649631..650467) Candidatus Blochmannia pennsylvanicus str. BPEN 3562882 YP_278033.1 CDS guaA NC_007292.1 650857 652434 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(650857..652434) Candidatus Blochmannia pennsylvanicus str. BPEN 3562883 YP_278034.1 CDS guaB NC_007292.1 652578 654047 R ortholog to Escherichia coli bnum: b2508; MultiFun: Metabolism 1.5.2.1, 1.7.33; inosine-5'-monophosphate dehydrogenase complement(652578..654047) Candidatus Blochmannia pennsylvanicus str. BPEN 3562884 YP_278035.1 CDS mqo NC_007292.1 654656 656203 D malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 654656..656203 Candidatus Blochmannia pennsylvanicus str. BPEN 3562885 YP_278036.1 CDS engA NC_007292.1 656296 657711 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(656296..657711) Candidatus Blochmannia pennsylvanicus str. BPEN 3562612 YP_278037.1 CDS hisS NC_007292.1 658032 659348 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(658032..659348) Candidatus Blochmannia pennsylvanicus str. BPEN 3562940 YP_278038.1 CDS ispG NC_007292.1 659362 660492 R ortholog to Escherichia coli bnum: b2515; MultiFun: Metabolism 1.5.3.19; 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase complement(659362..660492) Candidatus Blochmannia pennsylvanicus str. BPEN 3562941 YP_278039.1 CDS yfgB NC_007292.1 660713 661834 R ortholog to Escherichia coli bnum: b2517; MultiFun: Regulation 3.1.3.3; pyruvate formate lyase activating enzyme 2 complement(660713..661834) Candidatus Blochmannia pennsylvanicus str. BPEN 3562613 YP_278040.1 CDS ndk NC_007292.1 662040 662450 R multifunctional; ortholog to Escherichia coli bnum: b2518; MultiFun: Metabolism 1.5.2.3, 1.7.15, 1.7.33; apyrimidinic endonuclease; nucleoside diphosphate kinase; 3'-phosphodiesterase complement(662040..662450) Candidatus Blochmannia pennsylvanicus str. BPEN 3562614 YP_278041.1 CDS nifS NC_007292.1 662989 664158 R ortholog to Escherichia coli bnum: b2530; MultiFun: Information transfer 2.3.3; L-cysteine desulfurase complement(662989..664158) Candidatus Blochmannia pennsylvanicus str. BPEN 3562615 YP_278042.1 CDS suhB NC_007292.1 665003 665797 D ortholog to Escherichia coli bnum: b2533; MultiFun: Information transfer 2.2.2; Regulation 3.1.3.2; myo-inositol-1(or 4)-monophosphatase 665003..665797 Candidatus Blochmannia pennsylvanicus str. BPEN 3562767 YP_278043.1 CDS glyA NC_007292.1 665893 667143 R serine methylase; SHMT; ortholog to Escherichia coli bnum: b2551; MultiFun: Metabolism 1.1.3.5, 1.5.1.10, 1.5.3.2, 1.7.17; serine hydroxymethyltransferase complement(665893..667143) Candidatus Blochmannia pennsylvanicus str. BPEN 3562923 YP_278044.1 CDS tadA NC_007292.1 667443 667910 R ortholog to Escherichia coli bnum: b2559; MultiFun: Information transfer 2.2.5; tRNA-specific adenosine deaminase complement(667443..667910) Candidatus Blochmannia pennsylvanicus str. BPEN 3562919 YP_278045.1 CDS acpS NC_007292.1 668053 668430 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(668053..668430) Candidatus Blochmannia pennsylvanicus str. BPEN 3562920 YP_278046.1 CDS pdxJ NC_007292.1 668433 669167 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(668433..669167) Candidatus Blochmannia pennsylvanicus str. BPEN 3562921 YP_278047.1 CDS rnc NC_007292.1 669812 670501 R ortholog to Escherichia coli bnum: b2567; MultiFun: Information transfer 2.2.4; Metabolism 1.2.1; RNase III complement(669812..670501) Candidatus Blochmannia pennsylvanicus str. BPEN 3562922 YP_278048.1 CDS lepB NC_007292.1 670628 671623 R ortholog to Escherichia coli bnum: b2568; MultiFun: Cell structure 6.1; Information transfer 2.3.5; Transport 4.S.160; signal peptidase I complement(670628..671623) Candidatus Blochmannia pennsylvanicus str. BPEN 3562946 YP_278049.1 CDS lepA NC_007292.1 671642 673444 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(671642..673444) Candidatus Blochmannia pennsylvanicus str. BPEN 3562805 YP_278050.1 CDS ung NC_007292.1 673829 674521 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 673829..674521 Candidatus Blochmannia pennsylvanicus str. BPEN 3563128 YP_278051.1 CDS grpE NC_007292.1 674875 675462 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(674875..675462) Candidatus Blochmannia pennsylvanicus str. BPEN 3563129 YP_278052.1 CDS ppnK NC_007292.1 675593 676486 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 675593..676486 Candidatus Blochmannia pennsylvanicus str. BPEN 3563130 YP_278053.1 CDS smpA NC_007292.1 676582 676920 D ortholog to Escherichia coli bnum: b2617; MultiFun: Cell structure 6.1; small membrane protein A 676582..676920 Candidatus Blochmannia pennsylvanicus str. BPEN 3563131 YP_278054.1 CDS yfjG NC_007292.1 676950 677435 R ortholog to Escherichia coli bnum: b2619; hypothetical protein complement(676950..677435) Candidatus Blochmannia pennsylvanicus str. BPEN 3562944 YP_278055.1 CDS smpB NC_007292.1 677490 677954 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 677490..677954 Candidatus Blochmannia pennsylvanicus str. BPEN 3563197 YP_278056.1 CDS emrE NC_007292.1 678687 679016 D ortholog to Escherichia coli bnum: b0543; MultiFun: Cell processes 5.6.4; Cell structure 6.1; Transport 4.2.A.7, 4.S.126; auxillary SMR family multidrug transporter 678687..679016 Candidatus Blochmannia pennsylvanicus str. BPEN 3563220 YP_278057.1 CDS pssA NC_007292.1 679527 680903 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 679527..680903 Candidatus Blochmannia pennsylvanicus str. BPEN 3563221 YP_278058.1 CDS purH NC_007292.1 686483 688117 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 686483..688117 Candidatus Blochmannia pennsylvanicus str. BPEN 3563225 YP_278059.1 CDS rpoC NC_007292.1 688652 692902 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(688652..692902) Candidatus Blochmannia pennsylvanicus str. BPEN 3563226 YP_278060.1 CDS rpoB NC_007292.1 692991 697016 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(692991..697016) Candidatus Blochmannia pennsylvanicus str. BPEN 3563227 YP_278061.1 CDS rplL NC_007292.1 697272 697640 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(697272..697640) Candidatus Blochmannia pennsylvanicus str. BPEN 3563228 YP_278062.1 CDS rplJ NC_007292.1 697734 698225 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(697734..698225) Candidatus Blochmannia pennsylvanicus str. BPEN 3563229 YP_278063.1 CDS rplA NC_007292.1 698574 699281 R ortholog to Escherichia coli bnum: b3984; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; Regulation 3.1.3.1; 50S ribosomal protein L1 complement(698574..699281) Candidatus Blochmannia pennsylvanicus str. BPEN 3562943 YP_278064.1 CDS rplK NC_007292.1 699287 699718 R ortholog to Escherichia coli bnum: b3983; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L11 complement(699287..699718) Candidatus Blochmannia pennsylvanicus str. BPEN 3562926 YP_278065.1 CDS nusG NC_007292.1 699846 700391 R ortholog to Escherichia coli bnum: b3982; MultiFun: Information transfer 2.2.2; transcription antitermination protein complement(699846..700391) Candidatus Blochmannia pennsylvanicus str. BPEN 3563132 YP_278066.1 CDS secE NC_007292.1 700393 700740 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(700393..700740) Candidatus Blochmannia pennsylvanicus str. BPEN 3563133 YP_278067.1 CDS tuf NC_007292.1 700810 701994 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(700810..701994) Candidatus Blochmannia pennsylvanicus str. BPEN 3563134 YP_278068.1 CDS fusA NC_007292.1 702056 704170 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(702056..704170) Candidatus Blochmannia pennsylvanicus str. BPEN 3563135 YP_278069.1 CDS rpsG NC_007292.1 704294 704764 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(704294..704764) Candidatus Blochmannia pennsylvanicus str. BPEN 3563136 YP_278070.1 CDS rpsL NC_007292.1 704916 705290 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(704916..705290) Candidatus Blochmannia pennsylvanicus str. BPEN 3563137 YP_278071.1 CDS pabA NC_007292.1 707069 707650 R component of p-aminobenzoate synthase multienzyme complex; ortholog to Escherichia coli bnum: b3360; MultiFun: Metabolism 1.5.3.2; aminodeoxychorismate synthase subunit II complement(707069..707650) Candidatus Blochmannia pennsylvanicus str. BPEN 3563138 YP_278072.1 CDS trpS NC_007292.1 708033 709031 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(708033..709031) Candidatus Blochmannia pennsylvanicus str. BPEN 3562768 YP_278073.1 CDS rpe NC_007292.1 709268 709933 R ortholog to Escherichia coli bnum: b3386; MultiFun: Metabolism 1.1.1, 1.7.3; ribulose-phosphate 3-epimerase complement(709268..709933) Candidatus Blochmannia pennsylvanicus str. BPEN 3562769 YP_278074.1 CDS aroB NC_007292.1 710332 711420 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(710332..711420) Candidatus Blochmannia pennsylvanicus str. BPEN 3563064 YP_278075.1 CDS aroK NC_007292.1 711475 712038 R ortholog to Escherichia coli bnum: b3390; MultiFun: Metabolism 1.5.1.20; shikimate kinase I complement(711475..712038) Candidatus Blochmannia pennsylvanicus str. BPEN 3563065 YP_278076.1 CDS gntY NC_007292.1 713530 714120 D ortholog to Escherichia coli bnum: b3414; MultiFun: Transport 4.9.B; membrane-bound protein in GNT I transport system 713530..714120 Candidatus Blochmannia pennsylvanicus str. BPEN 3563066 YP_278077.1 CDS asd NC_007292.1 714278 715384 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(714278..715384) Candidatus Blochmannia pennsylvanicus str. BPEN 3563067 YP_278078.1 CDS yhgN NC_007292.1 715520 716113 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 715520..716113 Candidatus Blochmannia pennsylvanicus str. BPEN 3563068 YP_278079.1 CDS yigL NC_007292.1 716562 717401 R purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase complement(716562..717401) Candidatus Blochmannia pennsylvanicus str. BPEN 3563069 YP_278080.1 CDS corA NC_007292.1 717767 718711 R ortholog to Escherichia coli bnum: b3816; MultiFun: Cell structure 6.1; Transport 4.9.A.17, 4.S.121; Mg2+/Co2+ transporter complement(717767..718711) Candidatus Blochmannia pennsylvanicus str. BPEN 3563070 YP_278081.1 CDS yigB NC_007292.1 721179 721895 R ortholog to Escherichia coli bnum: b3812; HAD family hydrolase complement(721179..721895) Candidatus Blochmannia pennsylvanicus str. BPEN 3563072 YP_278082.1 CDS dapF NC_007292.1 722069 722893 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(722069..722893) Candidatus Blochmannia pennsylvanicus str. BPEN 3563073 YP_278083.1 CDS hemC NC_007292.1 723951 724853 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 723951..724853 Candidatus Blochmannia pennsylvanicus str. BPEN 3563074 YP_278084.1 CDS hemD NC_007292.1 724900 725649 D catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 724900..725649 Candidatus Blochmannia pennsylvanicus str. BPEN 3563075 YP_278085.1 CDS rho NC_007292.1 726829 728088 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(726829..728088) Candidatus Blochmannia pennsylvanicus str. BPEN 3563080 YP_278086.1 CDS trxA NC_007292.1 728530 728856 R ortholog to Escherichia coli bnum: b3781; MultiFun: Metabolism 1.6.15.2; thioredoxin complement(728530..728856) Candidatus Blochmannia pennsylvanicus str. BPEN 3563081 YP_278087.1 CDS ilvC NC_007292.1 729092 730567 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(729092..730567) Candidatus Blochmannia pennsylvanicus str. BPEN 3563082 YP_278088.1 CDS ilvA NC_007292.1 730628 732172 R threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase complement(730628..732172) Candidatus Blochmannia pennsylvanicus str. BPEN 3563083 YP_278089.1 CDS ilvD NC_007292.1 732181 734031 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(732181..734031) Candidatus Blochmannia pennsylvanicus str. BPEN 3563084 YP_278090.1 CDS ilvE NC_007292.1 734104 735024 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(734104..735024) Candidatus Blochmannia pennsylvanicus str. BPEN 3563085 YP_278091.1 CDS ilvM NC_007292.1 735085 735321 R ortholog to Escherichia coli bnum: b3769; MultiFun: Metabolism 1.5.1.18; acetolactate synthase 2 regulatory subunit complement(735085..735321) Candidatus Blochmannia pennsylvanicus str. BPEN 3562931 YP_278092.1 CDS ilvG NC_007292.1 735323 736963 R catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit complement(735323..736963) Candidatus Blochmannia pennsylvanicus str. BPEN 3562932 YP_278093.1 CDS murI NC_007292.1 739039 739872 R ortholog to Escherichia coli bnum: b3967; MultiFun: Cell structure 6.2; Metabolism 1.6.7; glutamate racemase complement(739039..739872) Candidatus Blochmannia pennsylvanicus str. BPEN 3562936 YP_278094.1 CDS metF NC_007292.1 740314 741207 R MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase complement(740314..741207) Candidatus Blochmannia pennsylvanicus str. BPEN 3562937 YP_278095.1 CDS metB NC_007292.1 741619 742767 R ortholog to Escherichia coli bnum: b3939; MultiFun: Metabolism 1.1.3.7, 1.5.1.9, 1.7.30; cystathionine gamma-synthase complement(741619..742767) Candidatus Blochmannia pennsylvanicus str. BPEN 3562938 YP_278096.1 CDS rpmE NC_007292.1 743051 743299 R RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(743051..743299) Candidatus Blochmannia pennsylvanicus str. BPEN 3562599 YP_278097.1 CDS fpr NC_007292.1 744760 745509 D ortholog to Escherichia coli bnum: b3924; MultiFun: Cell processes 5.6.2; Metabolism 1.7.1; ferredoxin-NADP reductase 744760..745509 Candidatus Blochmannia pennsylvanicus str. BPEN 3563230 YP_278098.1 CDS tpiA NC_007292.1 745741 746517 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 745741..746517 Candidatus Blochmannia pennsylvanicus str. BPEN 3563231 YP_278099.1 CDS pfkA NC_007292.1 746684 747652 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(746684..747652) Candidatus Blochmannia pennsylvanicus str. BPEN 3563232 YP_278100.1 CDS cysE NC_007292.1 748372 749121 R ortholog to Escherichia coli bnum: b3607; MultiFun: Metabolism 1.5.1.12; serine acetyltransferase complement(748372..749121) Candidatus Blochmannia pennsylvanicus str. BPEN 3563233 YP_278101.1 CDS gpsA NC_007292.1 749172 750206 R ortholog to Escherichia coli bnum: b3608; MultiFun: Metabolism 1.1.1.23, 1.7.6, 1.8.1; glycerol-3-phosphate dehydrogenase complement(749172..750206) Candidatus Blochmannia pennsylvanicus str. BPEN 3563234 YP_278102.1 CDS secB NC_007292.1 750237 750701 R enhances activity of SecA; general secretory pathway; ortholog to Escherichia coli bnum: b3609; MultiFun: Information transfer 2.3.4; Transport 4.S.160; molecular chaperone in protein export complement(750237..750701) Candidatus Blochmannia pennsylvanicus str. BPEN 3563235 YP_278103.1 CDS grxC NC_007292.1 750742 751017 R ortholog to Escherichia coli bnum: b3610; MultiFun: Metabolism 1.6.15.2; glutaredoxin 3 complement(750742..751017) Candidatus Blochmannia pennsylvanicus str. BPEN 3563236 YP_278104.1 CDS yibN NC_007292.1 751030 751479 R ortholog to Escherichia coli bnum: b3611; rhodanese-related sulfurtransferase complement(751030..751479) Candidatus Blochmannia pennsylvanicus str. BPEN 3563237 YP_278105.1 CDS hldD NC_007292.1 752038 753000 D ortholog to Escherichia coli bnum: b3619; MultiFun: Cell structure 6.3; Metabolism 1.5.3.7, 1.6.3.2; ADP-L-glycero-D-manno-heptose-6-epimerase 752038..753000 Candidatus Blochmannia pennsylvanicus str. BPEN 3563238 YP_278106.1 CDS rfaF NC_007292.1 753019 754059 D ortholog to Escherichia coli bnum: b3620; MultiFun: Cell structure 6.3; Metabolism 1.6.3.2; ADP-heptose:LPS heptosyltransferase 753019..754059 Candidatus Blochmannia pennsylvanicus str. BPEN 3563239 YP_278107.1 CDS rfaC NC_007292.1 754081 755052 D ortholog to Escherichia coli bnum: b3621; MultiFun: Cell structure 6.3; Metabolism 1.6.3.2; ADP-heptose:LPS heptosyltransferase 754081..755052 Candidatus Blochmannia pennsylvanicus str. BPEN 3562600 YP_278108.1 CDS kdtA NC_007292.1 756944 758227 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 756944..758227 Candidatus Blochmannia pennsylvanicus str. BPEN 3562601 YP_278109.1 CDS coaD NC_007292.1 758957 759472 D phosphopantetheine adenylyltransferase; ortholog to Escherichia coli bnum: b3634; MultiFun: Cell structure 6.3; Metabolism 1.5.3.5; CMP-deoxy-D-manno-octulosonate-lipid A transferase 758957..759472 Candidatus Blochmannia pennsylvanicus str. BPEN 3562602 YP_278110.1 CDS rpmG NC_007292.1 759697 759864 R ortholog to Escherichia coli bnum: b3636; MultiFun: Cell structure 6.6; Information transfer 2.3.2, 2.3.8; 50S ribosomal protein L33 complement(759697..759864) Candidatus Blochmannia pennsylvanicus str. BPEN 3562712 YP_278111.1 CDS rpmB NC_007292.1 759889 760116 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(759889..760116) Candidatus Blochmannia pennsylvanicus str. BPEN 3562713 YP_278112.1 CDS dfp NC_007292.1 760593 761801 D bifunctional; ortholog to Escherichia coli bnum: b3639; MultiFun: Information transfer 2.1.1; Metabolism 1.5.3.5; phosphopantothenoylcysteine synthetase, FMN-binding; 4'-phosphopantothenoylcysteine decarboxylase 760593..761801 Candidatus Blochmannia pennsylvanicus str. BPEN 3562714 YP_278113.1 CDS dut NC_007292.1 761788 762237 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 761788..762237 Candidatus Blochmannia pennsylvanicus str. BPEN 3562715 YP_278114.1 CDS yicC NC_007292.1 762965 763846 D ortholog to Escherichia coli bnum: b3644; hypothetical protein 762965..763846 Candidatus Blochmannia pennsylvanicus str. BPEN 3562716 YP_278115.1 CDS BPEN_640 NC_007292.1 764849 765289 D MarR family transcriptional regulator 764849..765289 Candidatus Blochmannia pennsylvanicus str. BPEN 3562717 YP_278116.1 CDS gmk NC_007292.1 765594 766232 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 765594..766232 Candidatus Blochmannia pennsylvanicus str. BPEN 3562718 YP_278117.1 CDS rpoZ NC_007292.1 766329 766520 D ortholog to Escherichia coli bnum: b3649; MultiFun: Information transfer 2.2.2; DNA-directed RNA polymerase subunit K/omega 766329..766520 Candidatus Blochmannia pennsylvanicus str. BPEN 3562719 YP_278118.1 CDS glnA NC_007292.1 767280 768704 D ortholog to Escherichia coli bnum: b3870; MultiFun: Metabolism 1.5.1.2, 1.8.3; glutamine synthetase 767280..768704 Candidatus Blochmannia pennsylvanicus str. BPEN 3562720 YP_278119.1 CDS yihA NC_007292.1 768897 769496 D ortholog to Escherichia coli bnum: b3865; MultiFun: Cell processes 5.2; GTP-binding protein 768897..769496 Candidatus Blochmannia pennsylvanicus str. BPEN 3562721 YP_278120.1 CDS polA NC_007292.1 769643 772453 R multifunctional; 5'->3' exonuclease; 3'->5' polymerase; 3'->5' exonuclease; ortholog to Escherichia coli bnum: b3863; MultiFun: Information transfer 2.1.1; DNA polymerase I complement(769643..772453) Candidatus Blochmannia pennsylvanicus str. BPEN 3562722 YP_278121.1 CDS dsbA NC_007292.1 772648 773277 R ortholog to Escherichia coli bnum: b3860; MultiFun: Cell processes 5.5; Information transfer 2.3.4; protein disulfide isomerase complement(772648..773277) Candidatus Blochmannia pennsylvanicus str. BPEN 3562723 YP_278122.1 CDS ubiD NC_007292.1 773904 775367 R ortholog to Escherichia coli bnum: b3843; MultiFun: Metabolism 1.3.6, 1.5.3.11; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(773904..775367) Candidatus Blochmannia pennsylvanicus str. BPEN 3562724 YP_278123.1 CDS ubiB NC_007292.1 775575 777215 R ortholog to Escherichia coli bnum: b3835; MultiFun: Metabolism 1.3.6, 1.5.3.11; Regulation 3.1.4; ubiquinone biosynthetic 2-octaprenylphenol hydroxylase complement(775575..777215) Candidatus Blochmannia pennsylvanicus str. BPEN 3562725 YP_278124.1 CDS ubiE NC_007292.1 777805 778569 R bifunctional; ortholog to Escherichia coli bnum: b3833; MultiFun: Metabolism 1.3.6, 1.3.7, 1.5.3.11; S-adenosylmethionine:2-DMK methyltransferase; 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase complement(777805..778569) Candidatus Blochmannia pennsylvanicus str. BPEN 3562726 YP_278125.1 CDS yigN NC_007292.1 778676 780244 R ortholog to Escherichia coli bnum: b3832; hypothetical protein complement(778676..780244) Candidatus Blochmannia pennsylvanicus str. BPEN 3562727 YP_278126.1 CDS udp NC_007292.1 780488 781285 R catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase complement(780488..781285) Candidatus Blochmannia pennsylvanicus str. BPEN 3562728 YP_278127.1 CDS metE NC_007292.1 781518 783812 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase complement(781518..783812) Candidatus Blochmannia pennsylvanicus str. BPEN 3562729 YP_278128.1 CDS rpoH NC_007292.1 784116 784964 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(784116..784964) Candidatus Blochmannia pennsylvanicus str. BPEN 3562730 YP_278129.1 CDS ftsY NC_007292.1 785572 786498 R ortholog to Escherichia coli bnum: b3464; MultiFun: Cell processes 5.1; Cell structure 6.1; Transport 4.3.A.5; cell division protein complement(785572..786498) Candidatus Blochmannia pennsylvanicus str. BPEN 3562731 YP_278130.1 CDS yhhF NC_007292.1 786893 787480 D ortholog to Escherichia coli bnum: b3465; methyltransferase 786893..787480 Candidatus Blochmannia pennsylvanicus str. BPEN 3562732 YP_278131.1 CDS pgi NC_007292.1 787575 789230 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(787575..789230) Candidatus Blochmannia pennsylvanicus str. BPEN 3562733 YP_278132.1 CDS metA NC_007292.1 789711 790625 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(789711..790625) Candidatus Blochmannia pennsylvanicus str. BPEN 3562734 BPEN_022 tRNA BPEN_022 NC_007292.1 25305 25378 D tRNA-Pro 25305..25378 Candidatus Blochmannia pennsylvanicus str. BPEN 3563203 BPEN_039 tRNA BPEN_039 NC_007292.1 49580 49662 D tRNA-Leu 49580..49662 Candidatus Blochmannia pennsylvanicus str. BPEN 3562886 BPEN_056 tRNA BPEN_056 NC_007292.1 67551 67625 R tRNA-Met complement(67551..67625) Candidatus Blochmannia pennsylvanicus str. BPEN 3563007 BPEN_070 tRNA BPEN_070 NC_007292.1 84233 84305 R tRNA-Phe complement(84233..84305) Candidatus Blochmannia pennsylvanicus str. BPEN 3563154 BPEN_078 tRNA BPEN_078 NC_007292.1 93827 93902 D tRNA-Gly 93827..93902 Candidatus Blochmannia pennsylvanicus str. BPEN 3563048 BPEN_105 tRNA BPEN_105 NC_007292.1 123302 123387 D tRNA-Leu 123302..123387 Candidatus Blochmannia pennsylvanicus str. BPEN 3563186 BPEN_106 tRNA BPEN_106 NC_007292.1 123459 123535 D tRNA-Met 123459..123535 Candidatus Blochmannia pennsylvanicus str. BPEN 3563164 BPEN_176 tRNA BPEN_176 NC_007292.1 225347 225438 D tRNA-Ser 225347..225438 Candidatus Blochmannia pennsylvanicus str. BPEN 3562671 BPEN_177 tRNA BPEN_177 NC_007292.1 225453 225526 D tRNA-Arg 225453..225526 Candidatus Blochmannia pennsylvanicus str. BPEN 3562672 BPEN_192 tRNA BPEN_192 NC_007292.1 241597 241669 D tRNA-Thr 241597..241669 Candidatus Blochmannia pennsylvanicus str. BPEN 3562911 BPEN_193 tRNA BPEN_193 NC_007292.1 241683 241764 D tRNA-Tyr 241683..241764 Candidatus Blochmannia pennsylvanicus str. BPEN 3562912 BPEN_195 tRNA BPEN_195 NC_007292.1 241930 242006 D tRNA-Thr 241930..242006 Candidatus Blochmannia pennsylvanicus str. BPEN 3562702 BPEN_234 tRNA BPEN_234 NC_007292.1 264259 264332 D tRNA-Thr 264259..264332 Candidatus Blochmannia pennsylvanicus str. BPEN 3562619 BPEN_314 tRNA BPEN_314 NC_007292.1 372439 372512 D tRNA-Arg 372439..372512 Candidatus Blochmannia pennsylvanicus str. BPEN 3562591 BPEN_327 tRNA BPEN_327 NC_007292.1 388628 388699 R tRNA-Gln complement(388628..388699) Candidatus Blochmannia pennsylvanicus str. BPEN 3563053 BPEN_328 tRNA BPEN_328 NC_007292.1 388783 388864 R tRNA-Leu complement(388783..388864) Candidatus Blochmannia pennsylvanicus str. BPEN 3563054 BPEN_329 tRNA BPEN_329 NC_007292.1 388892 388965 R tRNA-Met complement(388892..388965) Candidatus Blochmannia pennsylvanicus str. BPEN 3563055 BPEN_376 tRNA BPEN_376 NC_007292.1 443624 443697 R tRNA-Val complement(443624..443697) Candidatus Blochmannia pennsylvanicus str. BPEN 3562975 BPEN_425 tRNA BPEN_425 NC_007292.1 503721 503802 R tRNA-Leu complement(503721..503802) Candidatus Blochmannia pennsylvanicus str. BPEN 3562700 BPEN_426 tRNA BPEN_426 NC_007292.1 503817 503887 R tRNA-Cys complement(503817..503887) Candidatus Blochmannia pennsylvanicus str. BPEN 3562736 BPEN_428 tRNA BPEN_428 NC_007292.1 505354 505427 D tRNA-Lys 505354..505427 Candidatus Blochmannia pennsylvanicus str. BPEN 3562738 BPEN_429 tRNA BPEN_429 NC_007292.1 505723 505806 R tRNA-Ser complement(505723..505806) Candidatus Blochmannia pennsylvanicus str. BPEN 3562739 BPEN_471 tRNA BPEN_471 NC_007292.1 564571 564662 D tRNA-Ser 564571..564662 Candidatus Blochmannia pennsylvanicus str. BPEN 3562967 BPEN_472 tRNA BPEN_472 NC_007292.1 565110 565202 D tRNA-Ser 565110..565202 Candidatus Blochmannia pennsylvanicus str. BPEN 3562979 BPEN_473 tRNA BPEN_473 NC_007292.1 565484 565559 D tRNA-Asn 565484..565559 Candidatus Blochmannia pennsylvanicus str. BPEN 3562980 BPEN_489 tRNA BPEN_489 NC_007292.1 583842 583915 D tRNA-Pro 583842..583915 Candidatus Blochmannia pennsylvanicus str. BPEN 3562996 BPEN_517 tRNA BPEN_517 NC_007292.1 620052 620123 D tRNA-Arg 620052..620123 Candidatus Blochmannia pennsylvanicus str. BPEN 3563142 BPEN_520 tRNA BPEN_520 NC_007292.1 623512 623584 R tRNA-Ala complement(623512..623584) Candidatus Blochmannia pennsylvanicus str. BPEN 3563145 BPEN_522 tRNA BPEN_522 NC_007292.1 625335 625408 D tRNA-Val 625335..625408 Candidatus Blochmannia pennsylvanicus str. BPEN 3562949 BPEN_523 tRNA BPEN_523 NC_007292.1 625433 625505 D tRNA-Lys 625433..625505 Candidatus Blochmannia pennsylvanicus str. BPEN 3562950 BPEN_573 tRNA BPEN_573 NC_007292.1 684298 684370 R tRNA-Glu complement(684298..684370) Candidatus Blochmannia pennsylvanicus str. BPEN 3563223 BPEN_603 tRNA BPEN_603 NC_007292.1 725761 725834 R tRNA-Pro complement(725761..725834) Candidatus Blochmannia pennsylvanicus str. BPEN 3563076 BPEN_604 tRNA BPEN_604 NC_007292.1 725947 726032 R tRNA-Leu complement(725947..726032) Candidatus Blochmannia pennsylvanicus str. BPEN 3563077 BPEN_605 tRNA BPEN_605 NC_007292.1 726053 726127 R tRNA-His complement(726053..726127) Candidatus Blochmannia pennsylvanicus str. BPEN 3563078 BPEN_606 tRNA BPEN_606 NC_007292.1 726172 726245 R tRNA-Arg complement(726172..726245) Candidatus Blochmannia pennsylvanicus str. BPEN 3563079 BPEN_615 tRNA BPEN_615 NC_007292.1 738175 738248 R tRNA-Trp complement(738175..738248) Candidatus Blochmannia pennsylvanicus str. BPEN 3562933 BPEN_616 tRNA BPEN_616 NC_007292.1 738269 738342 R tRNA-Asp complement(738269..738342) Candidatus Blochmannia pennsylvanicus str. BPEN 3562934 BPEN_617 tRNA BPEN_617 NC_007292.1 738483 738555 R tRNA-Ala complement(738483..738555) Candidatus Blochmannia pennsylvanicus str. BPEN 3562935 BPEN_658 tRNA BPEN_658 NC_007292.1 790949 791025 D tRNA-Ile 790949..791025 Candidatus Blochmannia pennsylvanicus str. BPEN 3562735 BPEN_229 rRNA rrf NC_007292.1 260446 260562 D 5S ribosomal RNA 260446..260562 Candidatus Blochmannia pennsylvanicus str. BPEN 3563158 BPEN_574 rRNA rrl NC_007292.1 680991 683983 R 23S ribosomal RNA complement(680991..683983) Candidatus Blochmannia pennsylvanicus str. BPEN 3563222 BPEN_572 rRNA rrs NC_007292.1 684481 686050 R 16S ribosomal RNA complement(684481..686050) Candidatus Blochmannia pennsylvanicus str. BPEN 3563224