-- dump date 20140619_022537 -- class Genbank::misc_feature -- table misc_feature_note -- id note 291272000001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 291272000002 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 291272000003 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 291272000004 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 291272000005 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 291272000006 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 291272000007 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 291272000008 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 291272000009 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 291272000010 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 291272000011 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 291272000012 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 291272000013 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 291272000014 beta subunit interaction interface [polypeptide binding]; other site 291272000015 Walker A motif; other site 291272000016 ATP binding site [chemical binding]; other site 291272000017 Walker B motif; other site 291272000018 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 291272000019 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 291272000020 core domain interface [polypeptide binding]; other site 291272000021 delta subunit interface [polypeptide binding]; other site 291272000022 epsilon subunit interface [polypeptide binding]; other site 291272000023 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 291272000024 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 291272000025 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 291272000026 alpha subunit interaction interface [polypeptide binding]; other site 291272000027 Walker A motif; other site 291272000028 ATP binding site [chemical binding]; other site 291272000029 Walker B motif; other site 291272000030 inhibitor binding site; inhibition site 291272000031 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 291272000032 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 291272000033 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 291272000034 gamma subunit interface [polypeptide binding]; other site 291272000035 epsilon subunit interface [polypeptide binding]; other site 291272000036 LBP interface [polypeptide binding]; other site 291272000037 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 291272000038 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 291272000039 Substrate binding site; other site 291272000040 Mg++ binding site; other site 291272000041 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 291272000042 active site 291272000043 substrate binding site [chemical binding]; other site 291272000044 CoA binding site [chemical binding]; other site 291272000045 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 291272000046 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 291272000047 trmE is a tRNA modification GTPase; Region: trmE; cd04164 291272000048 G1 box; other site 291272000049 GTP/Mg2+ binding site [chemical binding]; other site 291272000050 Switch I region; other site 291272000051 G2 box; other site 291272000052 Switch II region; other site 291272000053 G3 box; other site 291272000054 G4 box; other site 291272000055 G5 box; other site 291272000056 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 291272000057 Haemolytic domain; Region: Haemolytic; pfam01809 291272000058 membrane protein insertase; Provisional; Region: PRK01318 291272000059 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 291272000060 ribonuclease P; Reviewed; Region: rnpA; PRK01732 291272000061 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 291272000062 DNA polymerase III subunit beta; Validated; Region: PRK05643 291272000063 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 291272000064 putative DNA binding surface [nucleotide binding]; other site 291272000065 dimer interface [polypeptide binding]; other site 291272000066 beta-clamp/clamp loader binding surface; other site 291272000067 beta-clamp/translesion DNA polymerase binding surface; other site 291272000068 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 291272000069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291272000070 Mg2+ binding site [ion binding]; other site 291272000071 G-X-G motif; other site 291272000072 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 291272000073 anchoring element; other site 291272000074 dimer interface [polypeptide binding]; other site 291272000075 ATP binding site [chemical binding]; other site 291272000076 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 291272000077 active site 291272000078 putative metal-binding site [ion binding]; other site 291272000079 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 291272000080 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 291272000081 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 291272000082 putative dimer interface [polypeptide binding]; other site 291272000083 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 291272000084 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 291272000085 motif 1; other site 291272000086 dimer interface [polypeptide binding]; other site 291272000087 active site 291272000088 motif 2; other site 291272000089 motif 3; other site 291272000090 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 291272000091 DALR anticodon binding domain; Region: DALR_1; pfam05746 291272000092 superoxide dismutase; Provisional; Region: PRK10925 291272000093 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 291272000094 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 291272000095 oligopeptidase A; Provisional; Region: PRK10911 291272000096 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 291272000097 active site 291272000098 Zn binding site [ion binding]; other site 291272000099 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 291272000100 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 291272000101 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 291272000102 UbiA prenyltransferase family; Region: UbiA; pfam01040 291272000103 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 291272000104 metal binding site 2 [ion binding]; metal-binding site 291272000105 putative DNA binding helix; other site 291272000106 metal binding site 1 [ion binding]; metal-binding site 291272000107 dimer interface [polypeptide binding]; other site 291272000108 structural Zn2+ binding site [ion binding]; other site 291272000109 replicative DNA helicase; Provisional; Region: PRK08006 291272000110 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 291272000111 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 291272000112 Walker A motif; other site 291272000113 ATP binding site [chemical binding]; other site 291272000114 Walker B motif; other site 291272000115 DNA binding loops [nucleotide binding] 291272000116 alternate predicted RBS 291272000117 possible site of translation initiation 291272000118 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 291272000119 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 291272000120 dimer interface [polypeptide binding]; other site 291272000121 ssDNA binding site [nucleotide binding]; other site 291272000122 tetramer (dimer of dimers) interface [polypeptide binding]; other site 291272000123 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 291272000124 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 291272000125 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 291272000126 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 291272000127 homotrimer interaction site [polypeptide binding]; other site 291272000128 putative active site [active] 291272000129 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 291272000130 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 291272000131 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 291272000132 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 291272000133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291272000134 active site 291272000135 HIGH motif; other site 291272000136 nucleotide binding site [chemical binding]; other site 291272000137 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 291272000138 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 291272000139 active site 291272000140 KMSKS motif; other site 291272000141 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 291272000142 tRNA binding surface [nucleotide binding]; other site 291272000143 anticodon binding site; other site 291272000144 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 291272000145 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 291272000146 multifunctional aminopeptidase A; Provisional; Region: PRK00913 291272000147 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 291272000148 interface (dimer of trimers) [polypeptide binding]; other site 291272000149 Substrate-binding/catalytic site; other site 291272000150 Zn-binding sites [ion binding]; other site 291272000151 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 291272000152 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 291272000153 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 291272000154 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 291272000155 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 291272000156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 291272000157 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291272000158 dimerization interface [polypeptide binding]; other site 291272000159 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 291272000160 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 291272000161 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 291272000162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 291272000163 ABC-ATPase subunit interface; other site 291272000164 dimer interface [polypeptide binding]; other site 291272000165 putative PBP binding regions; other site 291272000166 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 291272000167 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 291272000168 Walker A/P-loop; other site 291272000169 ATP binding site [chemical binding]; other site 291272000170 Q-loop/lid; other site 291272000171 ABC transporter signature motif; other site 291272000172 Walker B; other site 291272000173 D-loop; other site 291272000174 H-loop/switch region; other site 291272000175 OstA-like protein; Region: OstA; cl00844 291272000176 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 291272000177 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 291272000178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 291272000179 possible site of translation initiation 291272000180 alternate predicted RBS 291272000181 BolA-like protein; Region: BolA; cl00386 291272000182 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 291272000183 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 291272000184 hinge; other site 291272000185 active site 291272000186 serine endoprotease; Provisional; Region: PRK10139 291272000187 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 291272000188 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 291272000189 protein binding site [polypeptide binding]; other site 291272000190 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 291272000191 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 291272000192 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 291272000193 23S rRNA interface [nucleotide binding]; other site 291272000194 L3 interface [polypeptide binding]; other site 291272000195 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 291272000196 outer membrane lipoprotein; Provisional; Region: PRK11023 291272000197 BON domain; Region: BON; pfam04972 291272000198 BON domain; Region: BON; pfam04972 291272000199 alternate predicted RBS 291272000200 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 291272000201 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 291272000202 putative SAM binding site [chemical binding]; other site 291272000203 putative homodimer interface [polypeptide binding]; other site 291272000204 possible site of translation initiation 291272000205 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 291272000206 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 291272000207 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 291272000208 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 291272000209 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 291272000210 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 291272000211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291272000212 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 291272000213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 291272000214 DNA binding residues [nucleotide binding] 291272000215 DNA primase; Validated; Region: dnaG; PRK05667 291272000216 CHC2 zinc finger; Region: zf-CHC2; pfam01807 291272000217 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 291272000218 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 291272000219 active site 291272000220 metal binding site [ion binding]; metal-binding site 291272000221 interdomain interaction site; other site 291272000222 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 291272000223 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 291272000224 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 291272000225 UGMP family protein; Validated; Region: PRK09604 291272000226 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 291272000227 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 291272000228 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 291272000229 active site 291272000230 Bacitracin resistance protein BacA; Region: BacA; pfam02673 291272000231 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13298 291272000232 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 291272000233 active site 291272000234 NTP binding site [chemical binding]; other site 291272000235 metal binding triad [ion binding]; metal-binding site 291272000236 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 291272000237 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 291272000238 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 291272000239 putative ribose interaction site [chemical binding]; other site 291272000240 putative ADP binding site [chemical binding]; other site 291272000241 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 291272000242 active site 291272000243 nucleotide binding site [chemical binding]; other site 291272000244 HIGH motif; other site 291272000245 KMSKS motif; other site 291272000246 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 291272000247 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 291272000248 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 291272000249 putative acyl-acceptor binding pocket; other site 291272000250 cystathionine beta-lyase; Provisional; Region: PRK08114 291272000251 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291272000252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291272000253 catalytic residue [active] 291272000254 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 291272000255 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 291272000256 oligomerisation interface [polypeptide binding]; other site 291272000257 mobile loop; other site 291272000258 roof hairpin; other site 291272000259 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 291272000260 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 291272000261 ring oligomerisation interface [polypeptide binding]; other site 291272000262 ATP/Mg binding site [chemical binding]; other site 291272000263 stacking interactions; other site 291272000264 hinge regions; other site 291272000265 translation elongation factor P; Region: efp; TIGR00038 291272000266 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 291272000267 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 291272000268 RNA binding site [nucleotide binding]; other site 291272000269 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 291272000270 RNA binding site [nucleotide binding]; other site 291272000271 putative mechanosensitive channel protein; Provisional; Region: PRK10929 291272000272 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 291272000273 Mechanosensitive ion channel; Region: MS_channel; pfam00924 291272000274 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 291272000275 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 291272000276 catalytic site [active] 291272000277 putative active site [active] 291272000278 putative substrate binding site [chemical binding]; other site 291272000279 dimer interface [polypeptide binding]; other site 291272000280 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 291272000281 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 291272000282 AMIN domain; Region: AMIN; pfam11741 291272000283 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 291272000284 active site 291272000285 metal binding site [ion binding]; metal-binding site 291272000286 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 291272000287 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 291272000288 bacterial Hfq-like; Region: Hfq; cd01716 291272000289 hexamer interface [polypeptide binding]; other site 291272000290 Sm1 motif; other site 291272000291 RNA binding site [nucleotide binding]; other site 291272000292 Sm2 motif; other site 291272000293 GTPase HflX; Provisional; Region: PRK11058 291272000294 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 291272000295 HflX GTPase family; Region: HflX; cd01878 291272000296 G1 box; other site 291272000297 GTP/Mg2+ binding site [chemical binding]; other site 291272000298 Switch I region; other site 291272000299 G2 box; other site 291272000300 G3 box; other site 291272000301 Switch II region; other site 291272000302 G4 box; other site 291272000303 G5 box; other site 291272000304 FtsH protease regulator HflK; Provisional; Region: PRK10930 291272000305 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 291272000306 FtsH protease regulator HflC; Provisional; Region: PRK11029 291272000307 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 291272000308 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 291272000309 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 291272000310 GDP-binding site [chemical binding]; other site 291272000311 ACT binding site; other site 291272000312 IMP binding site; other site 291272000313 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 291272000314 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 291272000315 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 291272000316 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 291272000317 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 291272000318 alternate predicted RBS 291272000319 possible site of translation initiation 291272000320 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 291272000321 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 291272000322 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 291272000323 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 291272000324 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 291272000325 active site 291272000326 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 291272000327 Surface antigen; Region: Bac_surface_Ag; pfam01103 291272000328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 291272000329 Family of unknown function (DUF490); Region: DUF490; pfam04357 291272000330 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 291272000331 dimer interface [polypeptide binding]; other site 291272000332 substrate binding site [chemical binding]; other site 291272000333 metal binding sites [ion binding]; metal-binding site 291272000334 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 291272000335 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 291272000336 substrate binding pocket [chemical binding]; other site 291272000337 chain length determination region; other site 291272000338 substrate-Mg2+ binding site; other site 291272000339 catalytic residues [active] 291272000340 aspartate-rich region 1; other site 291272000341 active site lid residues [active] 291272000342 aspartate-rich region 2; other site 291272000343 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 291272000344 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 291272000345 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 291272000346 GTPase CgtA; Reviewed; Region: obgE; PRK12299 291272000347 GTP1/OBG; Region: GTP1_OBG; pfam01018 291272000348 Obg GTPase; Region: Obg; cd01898 291272000349 G1 box; other site 291272000350 GTP/Mg2+ binding site [chemical binding]; other site 291272000351 Switch I region; other site 291272000352 G2 box; other site 291272000353 G3 box; other site 291272000354 Switch II region; other site 291272000355 G4 box; other site 291272000356 G5 box; other site 291272000357 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 291272000358 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 291272000359 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 291272000360 FtsJ-like methyltransferase; Region: FtsJ; cl17430 291272000361 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 291272000362 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 291272000363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 291272000364 Walker A motif; other site 291272000365 ATP binding site [chemical binding]; other site 291272000366 Walker B motif; other site 291272000367 arginine finger; other site 291272000368 Peptidase family M41; Region: Peptidase_M41; pfam01434 291272000369 dihydropteroate synthase; Region: DHPS; TIGR01496 291272000370 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 291272000371 substrate binding pocket [chemical binding]; other site 291272000372 dimer interface [polypeptide binding]; other site 291272000373 inhibitor binding site; inhibition site 291272000374 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 291272000375 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 291272000376 active site 291272000377 substrate binding site [chemical binding]; other site 291272000378 metal binding site [ion binding]; metal-binding site 291272000379 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 291272000380 NusA N-terminal domain; Region: NusA_N; pfam08529 291272000381 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 291272000382 RNA binding site [nucleotide binding]; other site 291272000383 homodimer interface [polypeptide binding]; other site 291272000384 NusA-like KH domain; Region: KH_5; pfam13184 291272000385 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 291272000386 G-X-X-G motif; other site 291272000387 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 291272000388 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 291272000389 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 291272000390 translation initiation factor IF-2; Region: IF-2; TIGR00487 291272000391 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 291272000392 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 291272000393 G1 box; other site 291272000394 putative GEF interaction site [polypeptide binding]; other site 291272000395 GTP/Mg2+ binding site [chemical binding]; other site 291272000396 Switch I region; other site 291272000397 G2 box; other site 291272000398 G3 box; other site 291272000399 Switch II region; other site 291272000400 G4 box; other site 291272000401 G5 box; other site 291272000402 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 291272000403 Translation-initiation factor 2; Region: IF-2; pfam11987 291272000404 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 291272000405 Ribosome-binding factor A; Region: RBFA; pfam02033 291272000406 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 291272000407 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 291272000408 RNA binding site [nucleotide binding]; other site 291272000409 active site 291272000410 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 291272000411 16S/18S rRNA binding site [nucleotide binding]; other site 291272000412 S13e-L30e interaction site [polypeptide binding]; other site 291272000413 25S rRNA binding site [nucleotide binding]; other site 291272000414 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 291272000415 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 291272000416 RNase E interface [polypeptide binding]; other site 291272000417 trimer interface [polypeptide binding]; other site 291272000418 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 291272000419 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 291272000420 RNase E interface [polypeptide binding]; other site 291272000421 trimer interface [polypeptide binding]; other site 291272000422 active site 291272000423 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 291272000424 putative nucleic acid binding region [nucleotide binding]; other site 291272000425 G-X-X-G motif; other site 291272000426 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 291272000427 RNA binding site [nucleotide binding]; other site 291272000428 domain interface; other site 291272000429 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 291272000430 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 291272000431 ATP binding site [chemical binding]; other site 291272000432 Mg++ binding site [ion binding]; other site 291272000433 motif III; other site 291272000434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291272000435 nucleotide binding region [chemical binding]; other site 291272000436 ATP-binding site [chemical binding]; other site 291272000437 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 291272000438 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 291272000439 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 291272000440 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 291272000441 putative catalytic residues [active] 291272000442 putative nucleotide binding site [chemical binding]; other site 291272000443 putative aspartate binding site [chemical binding]; other site 291272000444 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 291272000445 dimer interface [polypeptide binding]; other site 291272000446 putative threonine allosteric regulatory site; other site 291272000447 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 291272000448 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 291272000449 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 291272000450 homoserine kinase; Provisional; Region: PRK01212 291272000451 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 291272000452 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 291272000453 threonine synthase; Validated; Region: PRK09225 291272000454 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 291272000455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291272000456 catalytic residue [active] 291272000457 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 291272000458 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 291272000459 nucleotide binding site [chemical binding]; other site 291272000460 chaperone protein DnaJ; Provisional; Region: PRK10767 291272000461 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 291272000462 HSP70 interaction site [polypeptide binding]; other site 291272000463 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 291272000464 Zn binding sites [ion binding]; other site 291272000465 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 291272000466 dimer interface [polypeptide binding]; other site 291272000467 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 291272000468 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 291272000469 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 291272000470 active site 291272000471 Riboflavin kinase; Region: Flavokinase; smart00904 291272000472 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 291272000473 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291272000474 active site 291272000475 HIGH motif; other site 291272000476 nucleotide binding site [chemical binding]; other site 291272000477 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 291272000478 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 291272000479 active site 291272000480 KMSKS motif; other site 291272000481 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 291272000482 tRNA binding surface [nucleotide binding]; other site 291272000483 anticodon binding site; other site 291272000484 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 291272000485 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 291272000486 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 291272000487 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 291272000488 dihydrodipicolinate reductase; Provisional; Region: PRK00048 291272000489 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 291272000490 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 291272000491 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 291272000492 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 291272000493 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 291272000494 catalytic site [active] 291272000495 subunit interface [polypeptide binding]; other site 291272000496 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 291272000497 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 291272000498 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 291272000499 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 291272000500 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 291272000501 ATP-grasp domain; Region: ATP-grasp_4; cl17255 291272000502 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 291272000503 substrate binding site [chemical binding]; other site 291272000504 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 291272000505 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 291272000506 folate binding site [chemical binding]; other site 291272000507 NADP+ binding site [chemical binding]; other site 291272000508 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 291272000509 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 291272000510 active site 291272000511 metal binding site [ion binding]; metal-binding site 291272000512 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 291272000513 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 291272000514 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 291272000515 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 291272000516 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 291272000517 SurA N-terminal domain; Region: SurA_N; pfam09312 291272000518 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 291272000519 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 291272000520 OstA-like protein; Region: OstA; cl00844 291272000521 Organic solvent tolerance protein; Region: OstA_C; pfam04453 291272000522 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 291272000523 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 291272000524 substrate binding site [chemical binding]; other site 291272000525 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 291272000526 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 291272000527 substrate binding site [chemical binding]; other site 291272000528 ligand binding site [chemical binding]; other site 291272000529 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 291272000530 tartrate dehydrogenase; Region: TTC; TIGR02089 291272000531 2-isopropylmalate synthase; Validated; Region: PRK00915 291272000532 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 291272000533 active site 291272000534 catalytic residues [active] 291272000535 metal binding site [ion binding]; metal-binding site 291272000536 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 291272000537 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 291272000538 MraW methylase family; Region: Methyltransf_5; cl17771 291272000539 Cell division protein FtsL; Region: FtsL; cl11433 291272000540 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 291272000541 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 291272000542 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 291272000543 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 291272000544 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 291272000545 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291272000546 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 291272000547 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 291272000548 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 291272000549 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291272000550 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 291272000551 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 291272000552 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 291272000553 Mg++ binding site [ion binding]; other site 291272000554 putative catalytic motif [active] 291272000555 putative substrate binding site [chemical binding]; other site 291272000556 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 291272000557 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291272000558 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 291272000559 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 291272000560 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 291272000561 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 291272000562 active site 291272000563 homodimer interface [polypeptide binding]; other site 291272000564 alternate predicted RBS 291272000565 possible site of translation initiation 291272000566 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 291272000567 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 291272000568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291272000569 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 291272000570 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 291272000571 Cell division protein FtsQ; Region: FtsQ; pfam03799 291272000572 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 291272000573 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 291272000574 Cell division protein FtsA; Region: FtsA; pfam14450 291272000575 cell division protein FtsZ; Validated; Region: PRK09330 291272000576 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 291272000577 nucleotide binding site [chemical binding]; other site 291272000578 SulA interaction site; other site 291272000579 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 291272000580 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 291272000581 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 291272000582 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 291272000583 SEC-C motif; Region: SEC-C; pfam02810 291272000584 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 291272000585 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 291272000586 CoA-binding site [chemical binding]; other site 291272000587 ATP-binding [chemical binding]; other site 291272000588 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 291272000589 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 291272000590 catalytic center binding site [active] 291272000591 ATP binding site [chemical binding]; other site 291272000592 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 291272000593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 291272000594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 291272000595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 291272000596 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 291272000597 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 291272000598 E3 interaction surface; other site 291272000599 lipoyl attachment site [posttranslational modification]; other site 291272000600 e3 binding domain; Region: E3_binding; pfam02817 291272000601 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 291272000602 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 291272000603 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 291272000604 dimer interface [polypeptide binding]; other site 291272000605 TPP-binding site [chemical binding]; other site 291272000606 penicillin-binding protein 1b; Provisional; Region: PRK14850 291272000607 Transglycosylase; Region: Transgly; pfam00912 291272000608 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 291272000609 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 291272000610 CTP synthetase; Validated; Region: pyrG; PRK05380 291272000611 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 291272000612 Catalytic site [active] 291272000613 active site 291272000614 UTP binding site [chemical binding]; other site 291272000615 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 291272000616 active site 291272000617 putative oxyanion hole; other site 291272000618 catalytic triad [active] 291272000619 enolase; Provisional; Region: eno; PRK00077 291272000620 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 291272000621 dimer interface [polypeptide binding]; other site 291272000622 metal binding site [ion binding]; metal-binding site 291272000623 substrate binding pocket [chemical binding]; other site 291272000624 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 291272000625 Flavodoxin; Region: Flavodoxin_1; pfam00258 291272000626 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 291272000627 FAD binding pocket [chemical binding]; other site 291272000628 FAD binding motif [chemical binding]; other site 291272000629 catalytic residues [active] 291272000630 NAD binding pocket [chemical binding]; other site 291272000631 phosphate binding motif [ion binding]; other site 291272000632 beta-alpha-beta structure motif; other site 291272000633 sulfite reductase subunit beta; Provisional; Region: PRK13504 291272000634 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 291272000635 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 291272000636 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 291272000637 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 291272000638 Active Sites [active] 291272000639 siroheme synthase; Provisional; Region: cysG; PRK10637 291272000640 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 291272000641 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 291272000642 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 291272000643 active site 291272000644 SAM binding site [chemical binding]; other site 291272000645 homodimer interface [polypeptide binding]; other site 291272000646 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 291272000647 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 291272000648 Active Sites [active] 291272000649 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 291272000650 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 291272000651 CysD dimerization site [polypeptide binding]; other site 291272000652 G1 box; other site 291272000653 putative GEF interaction site [polypeptide binding]; other site 291272000654 GTP/Mg2+ binding site [chemical binding]; other site 291272000655 Switch I region; other site 291272000656 G2 box; other site 291272000657 G3 box; other site 291272000658 Switch II region; other site 291272000659 G4 box; other site 291272000660 G5 box; other site 291272000661 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 291272000662 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 291272000663 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 291272000664 ligand-binding site [chemical binding]; other site 291272000665 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 291272000666 Septum formation initiator; Region: DivIC; cl17659 291272000667 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 291272000668 substrate binding site; other site 291272000669 dimer interface; other site 291272000670 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 291272000671 homotrimer interaction site [polypeptide binding]; other site 291272000672 zinc binding site [ion binding]; other site 291272000673 CDP-binding sites; other site 291272000674 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 291272000675 Peptidase family M23; Region: Peptidase_M23; pfam01551 291272000676 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 291272000677 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 291272000678 motif 1; other site 291272000679 active site 291272000680 motif 2; other site 291272000681 motif 3; other site 291272000682 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 291272000683 carbon storage regulator; Provisional; Region: PRK01712 291272000684 signal recognition particle protein; Provisional; Region: PRK10867 291272000685 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 291272000686 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 291272000687 Signal peptide binding domain; Region: SRP_SPB; pfam02978 291272000688 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 291272000689 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 291272000690 RimM N-terminal domain; Region: RimM; pfam01782 291272000691 PRC-barrel domain; Region: PRC; pfam05239 291272000692 alternate predicted RBS 291272000693 possible site of translation initiation 291272000694 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 291272000695 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 291272000696 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 291272000697 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 291272000698 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 291272000699 Chorismate mutase type II; Region: CM_2; cl00693 291272000700 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 291272000701 prephenate dehydrogenase; Validated; Region: PRK08507 291272000702 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 291272000703 Prephenate dehydratase; Region: PDT; pfam00800 291272000704 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 291272000705 alternate predicted RBS 291272000706 possible site of translation initiation 291272000707 Outer membrane lipoprotein; Region: YfiO; pfam13525 291272000708 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 291272000709 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 291272000710 RNA binding surface [nucleotide binding]; other site 291272000711 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 291272000712 active site 291272000713 protein disaggregation chaperone; Provisional; Region: PRK10865 291272000714 Clp amino terminal domain; Region: Clp_N; pfam02861 291272000715 Clp amino terminal domain; Region: Clp_N; pfam02861 291272000716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 291272000717 Walker A motif; other site 291272000718 ATP binding site [chemical binding]; other site 291272000719 Walker B motif; other site 291272000720 arginine finger; other site 291272000721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 291272000722 Walker A motif; other site 291272000723 ATP binding site [chemical binding]; other site 291272000724 Walker B motif; other site 291272000725 arginine finger; other site 291272000726 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 291272000727 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 291272000728 FAD binding domain; Region: FAD_binding_4; pfam01565 291272000729 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 291272000730 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 291272000731 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 291272000732 pantothenate kinase; Provisional; Region: PRK05439 291272000733 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 291272000734 ATP-binding site [chemical binding]; other site 291272000735 CoA-binding site [chemical binding]; other site 291272000736 Mg2+-binding site [ion binding]; other site 291272000737 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 291272000738 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 291272000739 heme binding site [chemical binding]; other site 291272000740 ferroxidase pore; other site 291272000741 ferroxidase diiron center [ion binding]; other site 291272000742 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 291272000743 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 291272000744 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 291272000745 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 291272000746 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 291272000747 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 291272000748 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 291272000749 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 291272000750 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 291272000751 protein-rRNA interface [nucleotide binding]; other site 291272000752 putative translocon binding site; other site 291272000753 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 291272000754 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 291272000755 G-X-X-G motif; other site 291272000756 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 291272000757 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 291272000758 23S rRNA interface [nucleotide binding]; other site 291272000759 5S rRNA interface [nucleotide binding]; other site 291272000760 putative antibiotic binding site [chemical binding]; other site 291272000761 L25 interface [polypeptide binding]; other site 291272000762 L27 interface [polypeptide binding]; other site 291272000763 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 291272000764 putative translocon interaction site; other site 291272000765 signal recognition particle (SRP54) interaction site; other site 291272000766 L23 interface [polypeptide binding]; other site 291272000767 trigger factor interaction site; other site 291272000768 23S rRNA interface [nucleotide binding]; other site 291272000769 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 291272000770 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 291272000771 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 291272000772 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 291272000773 RNA binding site [nucleotide binding]; other site 291272000774 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 291272000775 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 291272000776 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 291272000777 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 291272000778 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 291272000779 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 291272000780 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 291272000781 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 291272000782 5S rRNA interface [nucleotide binding]; other site 291272000783 L27 interface [polypeptide binding]; other site 291272000784 23S rRNA interface [nucleotide binding]; other site 291272000785 L5 interface [polypeptide binding]; other site 291272000786 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 291272000787 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 291272000788 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 291272000789 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 291272000790 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 291272000791 SecY translocase; Region: SecY; pfam00344 291272000792 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 291272000793 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 291272000794 30S ribosomal protein S13; Region: bact_S13; TIGR03631 291272000795 30S ribosomal protein S11; Validated; Region: PRK05309 291272000796 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 291272000797 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 291272000798 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 291272000799 RNA binding surface [nucleotide binding]; other site 291272000800 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 291272000801 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 291272000802 alphaNTD homodimer interface [polypeptide binding]; other site 291272000803 alphaNTD - beta interaction site [polypeptide binding]; other site 291272000804 alphaNTD - beta' interaction site [polypeptide binding]; other site 291272000805 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 291272000806 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 291272000807 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 291272000808 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 291272000809 putative active site [active] 291272000810 substrate binding site [chemical binding]; other site 291272000811 putative cosubstrate binding site; other site 291272000812 catalytic site [active] 291272000813 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 291272000814 substrate binding site [chemical binding]; other site 291272000815 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 291272000816 active site 291272000817 catalytic residues [active] 291272000818 metal binding site [ion binding]; metal-binding site 291272000819 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 291272000820 alternate predicted RBS 291272000821 possible site of translation initiation 291272000822 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 291272000823 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 291272000824 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 291272000825 shikimate binding site; other site 291272000826 NAD(P) binding site [chemical binding]; other site 291272000827 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 291272000828 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 291272000829 RNA/DNA hybrid binding site [nucleotide binding]; other site 291272000830 active site 291272000831 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 291272000832 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 291272000833 active site 291272000834 catalytic site [active] 291272000835 substrate binding site [chemical binding]; other site 291272000836 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 291272000837 dimer interface [polypeptide binding]; other site 291272000838 active site 291272000839 peroxidase; Provisional; Region: PRK15000 291272000840 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 291272000841 decamer (pentamer of dimers) interface [polypeptide binding]; other site 291272000842 catalytic triad [active] 291272000843 dimer interface [polypeptide binding]; other site 291272000844 peroxidatic and resolving cysteines [active] 291272000845 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 291272000846 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 291272000847 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 291272000848 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 291272000849 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 291272000850 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 291272000851 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 291272000852 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 291272000853 Protein export membrane protein; Region: SecD_SecF; cl14618 291272000854 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 291272000855 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 291272000856 catalytic motif [active] 291272000857 Zn binding site [ion binding]; other site 291272000858 RibD C-terminal domain; Region: RibD_C; cl17279 291272000859 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 291272000860 homopentamer interface [polypeptide binding]; other site 291272000861 active site 291272000862 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 291272000863 putative RNA binding site [nucleotide binding]; other site 291272000864 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 291272000865 tetramer interfaces [polypeptide binding]; other site 291272000866 binuclear metal-binding site [ion binding]; other site 291272000867 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 291272000868 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 291272000869 TPP-binding site; other site 291272000870 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 291272000871 PYR/PP interface [polypeptide binding]; other site 291272000872 dimer interface [polypeptide binding]; other site 291272000873 TPP binding site [chemical binding]; other site 291272000874 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 291272000875 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 291272000876 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 291272000877 substrate binding pocket [chemical binding]; other site 291272000878 chain length determination region; other site 291272000879 substrate-Mg2+ binding site; other site 291272000880 catalytic residues [active] 291272000881 aspartate-rich region 1; other site 291272000882 active site lid residues [active] 291272000883 aspartate-rich region 2; other site 291272000884 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 291272000885 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 291272000886 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 291272000887 Ligand Binding Site [chemical binding]; other site 291272000888 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 291272000889 active site residue [active] 291272000890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291272000891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 291272000892 putative substrate translocation pore; other site 291272000893 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 291272000894 UbiA prenyltransferase family; Region: UbiA; pfam01040 291272000895 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 291272000896 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 291272000897 Subunit I/III interface [polypeptide binding]; other site 291272000898 Subunit III/IV interface [polypeptide binding]; other site 291272000899 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 291272000900 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 291272000901 D-pathway; other site 291272000902 Putative ubiquinol binding site [chemical binding]; other site 291272000903 Low-spin heme (heme b) binding site [chemical binding]; other site 291272000904 Putative water exit pathway; other site 291272000905 Binuclear center (heme o3/CuB) [ion binding]; other site 291272000906 K-pathway; other site 291272000907 Putative proton exit pathway; other site 291272000908 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 291272000909 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 291272000910 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 291272000911 Clp protease; Region: CLP_protease; pfam00574 291272000912 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 291272000913 oligomer interface [polypeptide binding]; other site 291272000914 active site residues [active] 291272000915 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 291272000916 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 291272000917 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 291272000918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 291272000919 Walker A motif; other site 291272000920 ATP binding site [chemical binding]; other site 291272000921 Walker B motif; other site 291272000922 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 291272000923 oxidative damage protection protein; Provisional; Region: PRK05408 291272000924 adenine DNA glycosylase; Provisional; Region: PRK10880 291272000925 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 291272000926 minor groove reading motif; other site 291272000927 helix-hairpin-helix signature motif; other site 291272000928 substrate binding pocket [chemical binding]; other site 291272000929 active site 291272000930 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 291272000931 DNA binding and oxoG recognition site [nucleotide binding] 291272000932 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 291272000933 hypothetical protein; Validated; Region: PRK00228 291272000934 S-adenosylmethionine synthetase; Validated; Region: PRK05250 291272000935 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 291272000936 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 291272000937 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 291272000938 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 291272000939 agmatinase; Region: agmatinase; TIGR01230 291272000940 oligomer interface [polypeptide binding]; other site 291272000941 putative active site [active] 291272000942 Mn binding site [ion binding]; other site 291272000943 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 291272000944 Phosphoglycerate kinase; Region: PGK; pfam00162 291272000945 substrate binding site [chemical binding]; other site 291272000946 hinge regions; other site 291272000947 ADP binding site [chemical binding]; other site 291272000948 catalytic site [active] 291272000949 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 291272000950 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 291272000951 active site 291272000952 intersubunit interface [polypeptide binding]; other site 291272000953 zinc binding site [ion binding]; other site 291272000954 Na+ binding site [ion binding]; other site 291272000955 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 291272000956 tetramer (dimer of dimers) interface [polypeptide binding]; other site 291272000957 active site 291272000958 dimer interface [polypeptide binding]; other site 291272000959 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 291272000960 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 291272000961 Z-ring-associated protein; Provisional; Region: PRK10972 291272000962 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 291272000963 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 291272000964 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 291272000965 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 291272000966 putative global regulator; Reviewed; Region: PRK09559 291272000967 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 291272000968 peptide chain release factor 2; Validated; Region: prfB; PRK00578 291272000969 This domain is found in peptide chain release factors; Region: PCRF; smart00937 291272000970 RF-1 domain; Region: RF-1; pfam00472 291272000971 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 291272000972 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 291272000973 dimer interface [polypeptide binding]; other site 291272000974 putative anticodon binding site; other site 291272000975 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 291272000976 motif 1; other site 291272000977 active site 291272000978 motif 2; other site 291272000979 motif 3; other site 291272000980 diaminopimelate decarboxylase; Provisional; Region: PRK11165 291272000981 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 291272000982 active site 291272000983 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 291272000984 substrate binding site [chemical binding]; other site 291272000985 catalytic residues [active] 291272000986 dimer interface [polypeptide binding]; other site 291272000987 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 291272000988 putative active site [active] 291272000989 Ap4A binding site [chemical binding]; other site 291272000990 nudix motif; other site 291272000991 putative metal binding site [ion binding]; other site 291272000992 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 291272000993 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 291272000994 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 291272000995 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 291272000996 AAA domain; Region: AAA_30; pfam13604 291272000997 Family description; Region: UvrD_C_2; pfam13538 291272000998 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 291272000999 Family description; Region: UvrD_C_2; pfam13538 291272001000 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 291272001001 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 291272001002 trimer interface [polypeptide binding]; other site 291272001003 active site 291272001004 substrate binding site [chemical binding]; other site 291272001005 CoA binding site [chemical binding]; other site 291272001006 possible site of translation initiation 291272001007 alternate predicted RBS 291272001008 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 291272001009 active site 291272001010 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 291272001011 rRNA interaction site [nucleotide binding]; other site 291272001012 S8 interaction site; other site 291272001013 putative laminin-1 binding site; other site 291272001014 elongation factor Ts; Provisional; Region: tsf; PRK09377 291272001015 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 291272001016 Elongation factor TS; Region: EF_TS; pfam00889 291272001017 Elongation factor TS; Region: EF_TS; pfam00889 291272001018 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 291272001019 putative nucleotide binding site [chemical binding]; other site 291272001020 uridine monophosphate binding site [chemical binding]; other site 291272001021 homohexameric interface [polypeptide binding]; other site 291272001022 ribosome recycling factor; Reviewed; Region: frr; PRK00083 291272001023 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 291272001024 hinge region; other site 291272001025 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 291272001026 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 291272001027 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 291272001028 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 291272001029 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 291272001030 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 291272001031 catalytic residue [active] 291272001032 putative FPP diphosphate binding site; other site 291272001033 putative FPP binding hydrophobic cleft; other site 291272001034 dimer interface [polypeptide binding]; other site 291272001035 putative IPP diphosphate binding site; other site 291272001036 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 291272001037 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 291272001038 zinc metallopeptidase RseP; Provisional; Region: PRK10779 291272001039 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 291272001040 active site 291272001041 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 291272001042 protein binding site [polypeptide binding]; other site 291272001043 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 291272001044 protein binding site [polypeptide binding]; other site 291272001045 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 291272001046 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 291272001047 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 291272001048 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 291272001049 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 291272001050 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 291272001051 Surface antigen; Region: Bac_surface_Ag; pfam01103 291272001052 periplasmic chaperone; Provisional; Region: PRK10780 291272001053 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 291272001054 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 291272001055 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 291272001056 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 291272001057 trimer interface [polypeptide binding]; other site 291272001058 active site 291272001059 UDP-GlcNAc binding site [chemical binding]; other site 291272001060 lipid binding site [chemical binding]; lipid-binding site 291272001061 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 291272001062 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 291272001063 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 291272001064 active site 291272001065 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 291272001066 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 291272001067 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 291272001068 RNA/DNA hybrid binding site [nucleotide binding]; other site 291272001069 active site 291272001070 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 291272001071 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 291272001072 putative active site [active] 291272001073 putative PHP Thumb interface [polypeptide binding]; other site 291272001074 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 291272001075 generic binding surface I; other site 291272001076 generic binding surface II; other site 291272001077 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 291272001078 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 291272001079 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 291272001080 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 291272001081 Ligand Binding Site [chemical binding]; other site 291272001082 TilS substrate binding domain; Region: TilS; pfam09179 291272001083 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 291272001084 prolyl-tRNA synthetase; Provisional; Region: PRK09194 291272001085 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 291272001086 dimer interface [polypeptide binding]; other site 291272001087 motif 1; other site 291272001088 active site 291272001089 motif 2; other site 291272001090 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 291272001091 putative deacylase active site [active] 291272001092 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 291272001093 active site 291272001094 motif 3; other site 291272001095 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 291272001096 anticodon binding site; other site 291272001097 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 291272001098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 291272001099 active site 291272001100 motif I; other site 291272001101 motif II; other site 291272001102 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 291272001103 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 291272001104 ATP-grasp domain; Region: ATP-grasp_4; cl17255 291272001105 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 291272001106 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 291272001107 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 291272001108 carboxyltransferase (CT) interaction site; other site 291272001109 biotinylation site [posttranslational modification]; other site 291272001110 Dehydroquinase class II; Region: DHquinase_II; pfam01220 291272001111 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 291272001112 active site 291272001113 trimer interface [polypeptide binding]; other site 291272001114 dimer interface [polypeptide binding]; other site 291272001115 rod shape-determining protein MreB; Provisional; Region: PRK13927 291272001116 MreB and similar proteins; Region: MreB_like; cd10225 291272001117 nucleotide binding site [chemical binding]; other site 291272001118 Mg binding site [ion binding]; other site 291272001119 putative protofilament interaction site [polypeptide binding]; other site 291272001120 RodZ interaction site [polypeptide binding]; other site 291272001121 rod shape-determining protein MreC; Provisional; Region: PRK13922 291272001122 rod shape-determining protein MreC; Region: MreC; pfam04085 291272001123 rod shape-determining protein MreD; Region: MreD; cl01087 291272001124 protease TldD; Provisional; Region: tldD; PRK10735 291272001125 peptidase PmbA; Provisional; Region: PRK11040 291272001126 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 291272001127 Found in ATP-dependent protease La (LON); Region: LON; smart00464 291272001128 Found in ATP-dependent protease La (LON); Region: LON; smart00464 291272001129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 291272001130 Walker A motif; other site 291272001131 ATP binding site [chemical binding]; other site 291272001132 Walker B motif; other site 291272001133 arginine finger; other site 291272001134 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 291272001135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 291272001136 active site 291272001137 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 291272001138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 291272001139 Walker A motif; other site 291272001140 ATP binding site [chemical binding]; other site 291272001141 Walker B motif; other site 291272001142 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 291272001143 arginine finger; other site 291272001144 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 291272001145 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 291272001146 adenylate kinase; Reviewed; Region: adk; PRK00279 291272001147 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 291272001148 AMP-binding site [chemical binding]; other site 291272001149 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 291272001150 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 291272001151 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 291272001152 putative active site [active] 291272001153 putative metal binding site [ion binding]; other site 291272001154 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 291272001155 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 291272001156 active site 291272001157 HIGH motif; other site 291272001158 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 291272001159 KMSKS motif; other site 291272001160 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 291272001161 tRNA binding surface [nucleotide binding]; other site 291272001162 anticodon binding site; other site 291272001163 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 291272001164 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 291272001165 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 291272001166 homodimer interface [polypeptide binding]; other site 291272001167 NADP binding site [chemical binding]; other site 291272001168 substrate binding site [chemical binding]; other site 291272001169 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 291272001170 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 291272001171 penicillin-binding protein 2; Provisional; Region: PRK10795 291272001172 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 291272001173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 291272001174 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 291272001175 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 291272001176 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 291272001177 Lipopolysaccharide-assembly; Region: LptE; cl01125 291272001178 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 291272001179 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 291272001180 HIGH motif; other site 291272001181 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 291272001182 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291272001183 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291272001184 active site 291272001185 KMSKS motif; other site 291272001186 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 291272001187 tRNA binding surface [nucleotide binding]; other site 291272001188 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 291272001189 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 291272001190 putative active site [active] 291272001191 catalytic triad [active] 291272001192 putative dimer interface [polypeptide binding]; other site 291272001193 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 291272001194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 291272001195 Transporter associated domain; Region: CorC_HlyC; smart01091 291272001196 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 291272001197 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 291272001198 PhoH-like protein; Region: PhoH; pfam02562 291272001199 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 291272001200 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 291272001201 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 291272001202 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 291272001203 active site 291272001204 dimer interface [polypeptide binding]; other site 291272001205 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 291272001206 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 291272001207 active site 291272001208 trimer interface [polypeptide binding]; other site 291272001209 allosteric site; other site 291272001210 active site lid [active] 291272001211 hexamer (dimer of trimers) interface [polypeptide binding]; other site 291272001212 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 291272001213 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291272001214 active site 291272001215 HIGH motif; other site 291272001216 nucleotide binding site [chemical binding]; other site 291272001217 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291272001218 active site 291272001219 KMSKS motif; other site 291272001220 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 291272001221 flavodoxin FldA; Validated; Region: PRK09267 291272001222 acyl-CoA esterase; Provisional; Region: PRK10673 291272001223 PGAP1-like protein; Region: PGAP1; pfam07819 291272001224 phosphoglucomutase; Validated; Region: PRK07564 291272001225 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 291272001226 active site 291272001227 substrate binding site [chemical binding]; other site 291272001228 metal binding site [ion binding]; metal-binding site 291272001229 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 291272001230 Iron-sulfur protein interface; other site 291272001231 proximal quinone binding site [chemical binding]; other site 291272001232 SdhD (CybS) interface [polypeptide binding]; other site 291272001233 proximal heme binding site [chemical binding]; other site 291272001234 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 291272001235 SdhC subunit interface [polypeptide binding]; other site 291272001236 proximal heme binding site [chemical binding]; other site 291272001237 cardiolipin binding site; other site 291272001238 Iron-sulfur protein interface; other site 291272001239 proximal quinone binding site [chemical binding]; other site 291272001240 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 291272001241 L-aspartate oxidase; Provisional; Region: PRK06175 291272001242 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 291272001243 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 291272001244 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 291272001245 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 291272001246 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 291272001247 TPP-binding site [chemical binding]; other site 291272001248 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 291272001249 dimer interface [polypeptide binding]; other site 291272001250 PYR/PP interface [polypeptide binding]; other site 291272001251 TPP binding site [chemical binding]; other site 291272001252 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 291272001253 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 291272001254 E3 interaction surface; other site 291272001255 lipoyl attachment site [posttranslational modification]; other site 291272001256 e3 binding domain; Region: E3_binding; pfam02817 291272001257 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 291272001258 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 291272001259 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 291272001260 CoA-ligase; Region: Ligase_CoA; pfam00549 291272001261 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 291272001262 CoA binding domain; Region: CoA_binding; pfam02629 291272001263 CoA-ligase; Region: Ligase_CoA; pfam00549 291272001264 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 291272001265 TolR protein; Region: tolR; TIGR02801 291272001266 TolA C-terminal; Region: TolA; pfam06519 291272001267 translocation protein TolB; Provisional; Region: tolB; PRK03629 291272001268 TolB amino-terminal domain; Region: TolB_N; pfam04052 291272001269 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291272001270 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291272001271 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291272001272 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 291272001273 ligand binding site [chemical binding]; other site 291272001274 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 291272001275 Tetratricopeptide repeat; Region: TPR_6; pfam13174 291272001276 Tetratricopeptide repeat; Region: TPR_6; pfam13174 291272001277 6-phosphogluconolactonase; Provisional; Region: PRK11028 291272001278 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 291272001279 catalytic core [active] 291272001280 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 291272001281 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 291272001282 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 291272001283 GTP-binding protein YchF; Reviewed; Region: PRK09601 291272001284 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 291272001285 G1 box; other site 291272001286 GTP/Mg2+ binding site [chemical binding]; other site 291272001287 G2 box; other site 291272001288 Switch I region; other site 291272001289 G3 box; other site 291272001290 Switch II region; other site 291272001291 G4 box; other site 291272001292 G5 box; other site 291272001293 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 291272001294 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 291272001295 putative active site [active] 291272001296 catalytic residue [active] 291272001297 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 291272001298 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 291272001299 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 291272001300 active site 291272001301 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 291272001302 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 291272001303 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 291272001304 peptide chain release factor 1; Validated; Region: prfA; PRK00591 291272001305 This domain is found in peptide chain release factors; Region: PCRF; smart00937 291272001306 RF-1 domain; Region: RF-1; pfam00472 291272001307 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 291272001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 291272001309 S-adenosylmethionine binding site [chemical binding]; other site 291272001310 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 291272001311 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 291272001312 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 291272001313 active site 291272001314 dimer interface [polypeptide binding]; other site 291272001315 motif 1; other site 291272001316 motif 2; other site 291272001317 motif 3; other site 291272001318 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 291272001319 anticodon binding site; other site 291272001320 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 291272001321 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 291272001322 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 291272001323 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 291272001324 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 291272001325 23S rRNA binding site [nucleotide binding]; other site 291272001326 L21 binding site [polypeptide binding]; other site 291272001327 L13 binding site [polypeptide binding]; other site 291272001328 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 291272001329 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 291272001330 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 291272001331 dimer interface [polypeptide binding]; other site 291272001332 motif 1; other site 291272001333 active site 291272001334 motif 2; other site 291272001335 motif 3; other site 291272001336 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 291272001337 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 291272001338 putative tRNA-binding site [nucleotide binding]; other site 291272001339 B3/4 domain; Region: B3_4; pfam03483 291272001340 tRNA synthetase B5 domain; Region: B5; smart00874 291272001341 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 291272001342 dimer interface [polypeptide binding]; other site 291272001343 motif 1; other site 291272001344 motif 3; other site 291272001345 motif 2; other site 291272001346 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 291272001347 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 291272001348 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 291272001349 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 291272001350 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 291272001351 putative ABC transporter; Region: ycf24; CHL00085 291272001352 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 291272001353 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 291272001354 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 291272001355 Walker A/P-loop; other site 291272001356 ATP binding site [chemical binding]; other site 291272001357 Q-loop/lid; other site 291272001358 ABC transporter signature motif; other site 291272001359 Walker B; other site 291272001360 D-loop; other site 291272001361 H-loop/switch region; other site 291272001362 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 291272001363 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 291272001364 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 291272001365 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 291272001366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291272001367 catalytic residue [active] 291272001368 Fe-S metabolism associated domain; Region: SufE; cl00951 291272001369 murein lipoprotein; Provisional; Region: PRK15396 291272001370 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 291272001371 Lumazine binding domain; Region: Lum_binding; pfam00677 291272001372 Lumazine binding domain; Region: Lum_binding; pfam00677 291272001373 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 291272001374 putative GSH binding site [chemical binding]; other site 291272001375 catalytic residues [active] 291272001376 ribonuclease T; Provisional; Region: PRK05168 291272001377 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 291272001378 active site 291272001379 catalytic site [active] 291272001380 substrate binding site [chemical binding]; other site 291272001381 transcriptional regulator SlyA; Provisional; Region: PRK03573 291272001382 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 291272001383 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 291272001384 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 291272001385 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 291272001386 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 291272001387 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 291272001388 active site 291272001389 HIGH motif; other site 291272001390 dimer interface [polypeptide binding]; other site 291272001391 KMSKS motif; other site 291272001392 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 291272001393 RNA binding surface [nucleotide binding]; other site 291272001394 endonuclease III; Provisional; Region: PRK10702 291272001395 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 291272001396 minor groove reading motif; other site 291272001397 helix-hairpin-helix signature motif; other site 291272001398 substrate binding pocket [chemical binding]; other site 291272001399 active site 291272001400 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 291272001401 fumarate hydratase; Reviewed; Region: fumC; PRK00485 291272001402 Class II fumarases; Region: Fumarase_classII; cd01362 291272001403 active site 291272001404 tetramer interface [polypeptide binding]; other site 291272001405 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 291272001406 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 291272001407 Flavoprotein; Region: Flavoprotein; pfam02441 291272001408 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 291272001409 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 291272001410 Ligand binding site; other site 291272001411 oligomer interface; other site 291272001412 Uncharacterized conserved protein [Function unknown]; Region: COG2835 291272001413 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 291272001414 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 291272001415 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 291272001416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 291272001417 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 291272001418 Walker A/P-loop; other site 291272001419 ATP binding site [chemical binding]; other site 291272001420 Q-loop/lid; other site 291272001421 ABC transporter signature motif; other site 291272001422 Walker B; other site 291272001423 D-loop; other site 291272001424 H-loop/switch region; other site 291272001425 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 291272001426 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 291272001427 RNA binding site [nucleotide binding]; other site 291272001428 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 291272001429 RNA binding site [nucleotide binding]; other site 291272001430 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 291272001431 RNA binding site [nucleotide binding]; other site 291272001432 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 291272001433 RNA binding site [nucleotide binding]; other site 291272001434 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 291272001435 RNA binding site [nucleotide binding]; other site 291272001436 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 291272001437 RNA binding site [nucleotide binding]; other site 291272001438 cytidylate kinase; Provisional; Region: cmk; PRK00023 291272001439 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 291272001440 CMP-binding site; other site 291272001441 The sites determining sugar specificity; other site 291272001442 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 291272001443 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 291272001444 hinge; other site 291272001445 active site 291272001446 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 291272001447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291272001448 catalytic residue [active] 291272001449 seryl-tRNA synthetase; Provisional; Region: PRK05431 291272001450 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 291272001451 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 291272001452 dimer interface [polypeptide binding]; other site 291272001453 active site 291272001454 motif 1; other site 291272001455 motif 2; other site 291272001456 motif 3; other site 291272001457 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 291272001458 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 291272001459 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 291272001460 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 291272001461 thioredoxin reductase; Provisional; Region: PRK10262 291272001462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 291272001463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 291272001464 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 291272001465 rRNA binding site [nucleotide binding]; other site 291272001466 predicted 30S ribosome binding site; other site 291272001467 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291272001468 N-terminal plug; other site 291272001469 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 291272001470 ligand-binding site [chemical binding]; other site 291272001471 possible site of translation initiation 291272001472 alternate predicted RBS 291272001473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 291272001474 DNA binding site [nucleotide binding] 291272001475 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 291272001476 N-acetyl-D-glucosamine binding site [chemical binding]; other site 291272001477 catalytic residue [active] 291272001478 manganese transport regulator MntR; Provisional; Region: PRK11050 291272001479 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 291272001480 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 291272001481 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 291272001482 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 291272001483 adenylosuccinate lyase; Provisional; Region: PRK09285 291272001484 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 291272001485 tetramer interface [polypeptide binding]; other site 291272001486 active site 291272001487 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 291272001488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 291272001489 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 291272001490 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 291272001491 Walker A/P-loop; other site 291272001492 ATP binding site [chemical binding]; other site 291272001493 Q-loop/lid; other site 291272001494 ABC transporter signature motif; other site 291272001495 Walker B; other site 291272001496 D-loop; other site 291272001497 H-loop/switch region; other site 291272001498 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 291272001499 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 291272001500 FtsX-like permease family; Region: FtsX; pfam02687 291272001501 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 291272001502 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 291272001503 nucleotide binding site/active site [active] 291272001504 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 291272001505 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 291272001506 active site 291272001507 DNA polymerase III subunit delta'; Validated; Region: PRK07993 291272001508 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 291272001509 thymidylate kinase; Validated; Region: tmk; PRK00698 291272001510 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 291272001511 TMP-binding site; other site 291272001512 ATP-binding site [chemical binding]; other site 291272001513 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 291272001514 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 291272001515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291272001516 catalytic residue [active] 291272001517 acyl carrier protein; Provisional; Region: acpP; PRK00982 291272001518 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 291272001519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291272001520 NAD(P) binding site [chemical binding]; other site 291272001521 active site 291272001522 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 291272001523 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 291272001524 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 291272001525 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 291272001526 dimer interface [polypeptide binding]; other site 291272001527 active site 291272001528 CoA binding pocket [chemical binding]; other site 291272001529 putative phosphate acyltransferase; Provisional; Region: PRK05331 291272001530 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 291272001531 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 291272001532 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 291272001533 RNA binding surface [nucleotide binding]; other site 291272001534 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 291272001535 active site 291272001536 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 291272001537 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 291272001538 homodimer interface [polypeptide binding]; other site 291272001539 oligonucleotide binding site [chemical binding]; other site 291272001540 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 291272001541 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 291272001542 putative acyl-acceptor binding pocket; other site 291272001543 L,D-transpeptidase; Provisional; Region: PRK10260 291272001544 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 291272001545 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 291272001546 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 291272001547 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 291272001548 heat shock protein HspQ; Provisional; Region: PRK14129 291272001549 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 291272001550 active site 1 [active] 291272001551 dimer interface [polypeptide binding]; other site 291272001552 active site 2 [active] 291272001553 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 291272001554 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 291272001555 putative dimer interface [polypeptide binding]; other site 291272001556 putative anticodon binding site; other site 291272001557 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 291272001558 homodimer interface [polypeptide binding]; other site 291272001559 motif 1; other site 291272001560 motif 2; other site 291272001561 active site 291272001562 motif 3; other site 291272001563 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 291272001564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 291272001565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291272001566 homodimer interface [polypeptide binding]; other site 291272001567 catalytic residue [active] 291272001568 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 291272001569 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 291272001570 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 291272001571 NAD binding site [chemical binding]; other site 291272001572 homotetramer interface [polypeptide binding]; other site 291272001573 homodimer interface [polypeptide binding]; other site 291272001574 substrate binding site [chemical binding]; other site 291272001575 active site 291272001576 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 291272001577 dimerization interface [polypeptide binding]; other site 291272001578 active site 291272001579 anthranilate synthase component I; Provisional; Region: PRK13564 291272001580 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 291272001581 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 291272001582 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 291272001583 Glutamine amidotransferase class-I; Region: GATase; pfam00117 291272001584 glutamine binding [chemical binding]; other site 291272001585 catalytic triad [active] 291272001586 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 291272001587 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 291272001588 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 291272001589 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 291272001590 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 291272001591 active site 291272001592 ribulose/triose binding site [chemical binding]; other site 291272001593 phosphate binding site [ion binding]; other site 291272001594 substrate (anthranilate) binding pocket [chemical binding]; other site 291272001595 product (indole) binding pocket [chemical binding]; other site 291272001596 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 291272001597 active site 291272001598 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 291272001599 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 291272001600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291272001601 catalytic residue [active] 291272001602 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 291272001603 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 291272001604 substrate binding site [chemical binding]; other site 291272001605 active site 291272001606 catalytic residues [active] 291272001607 heterodimer interface [polypeptide binding]; other site 291272001608 hypothetical protein; Provisional; Region: PRK02868 291272001609 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 291272001610 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 291272001611 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 291272001612 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 291272001613 putative active site [active] 291272001614 catalytic site [active] 291272001615 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 291272001616 putative active site [active] 291272001617 catalytic site [active] 291272001618 thymidine kinase; Provisional; Region: PRK04296 291272001619 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 291272001620 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 291272001621 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 291272001622 putative catalytic site [active] 291272001623 putative phosphate binding site [ion binding]; other site 291272001624 active site 291272001625 metal binding site A [ion binding]; metal-binding site 291272001626 DNA binding site [nucleotide binding] 291272001627 putative AP binding site [nucleotide binding]; other site 291272001628 putative metal binding site B [ion binding]; other site 291272001629 protease 4; Provisional; Region: PRK10949 291272001630 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 291272001631 tandem repeat interface [polypeptide binding]; other site 291272001632 oligomer interface [polypeptide binding]; other site 291272001633 active site residues [active] 291272001634 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 291272001635 oligomer interface [polypeptide binding]; other site 291272001636 tandem repeat interface [polypeptide binding]; other site 291272001637 active site residues [active] 291272001638 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 291272001639 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 291272001640 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 291272001641 disulfide bond formation protein B; Provisional; Region: PRK01749 291272001642 septum formation inhibitor; Reviewed; Region: minC; PRK03511 291272001643 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 291272001644 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 291272001645 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 291272001646 Switch I; other site 291272001647 Switch II; other site 291272001648 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 291272001649 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 291272001650 Glycoprotease family; Region: Peptidase_M22; pfam00814 291272001651 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 291272001652 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 291272001653 chorismate binding enzyme; Region: Chorismate_bind; cl10555 291272001654 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 291272001655 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 291272001656 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 291272001657 Transporter associated domain; Region: CorC_HlyC; smart01091 291272001658 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 291272001659 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 291272001660 active pocket/dimerization site; other site 291272001661 active site 291272001662 phosphorylation site [posttranslational modification] 291272001663 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 291272001664 active site 291272001665 phosphorylation site [posttranslational modification] 291272001666 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 291272001667 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 291272001668 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 291272001669 DNA-binding site [nucleotide binding]; DNA binding site 291272001670 RNA-binding motif; other site 291272001671 heat shock protein HtpX; Provisional; Region: PRK05457 291272001672 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 291272001673 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 291272001674 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 291272001675 pyruvate kinase; Provisional; Region: PRK05826 291272001676 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 291272001677 domain interfaces; other site 291272001678 active site 291272001679 putative peptidase; Provisional; Region: PRK11649 291272001680 Peptidase family M23; Region: Peptidase_M23; pfam01551 291272001681 possible alternative site of translation initiation 291272001682 alternate predicted RBS 291272001683 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 291272001684 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 291272001685 dimer interface [polypeptide binding]; other site 291272001686 anticodon binding site; other site 291272001687 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 291272001688 homodimer interface [polypeptide binding]; other site 291272001689 motif 1; other site 291272001690 active site 291272001691 motif 2; other site 291272001692 GAD domain; Region: GAD; pfam02938 291272001693 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 291272001694 active site 291272001695 motif 3; other site 291272001696 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 291272001697 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 291272001698 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 291272001699 active site 291272001700 HIGH motif; other site 291272001701 KMSK motif region; other site 291272001702 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 291272001703 tRNA binding surface [nucleotide binding]; other site 291272001704 anticodon binding site; other site 291272001705 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 291272001706 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 291272001707 multidrug resistance protein MdtH; Provisional; Region: PRK11646 291272001708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291272001709 putative substrate translocation pore; other site 291272001710 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 291272001711 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 291272001712 putative active site [active] 291272001713 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 291272001714 hypothetical protein; Provisional; Region: PRK05423 291272001715 exonuclease I; Provisional; Region: sbcB; PRK11779 291272001716 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 291272001717 active site 291272001718 catalytic site [active] 291272001719 substrate binding site [chemical binding]; other site 291272001720 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 291272001721 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 291272001722 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 291272001723 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 291272001724 histidinol dehydrogenase; Region: hisD; TIGR00069 291272001725 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 291272001726 NAD binding site [chemical binding]; other site 291272001727 dimerization interface [polypeptide binding]; other site 291272001728 product binding site; other site 291272001729 substrate binding site [chemical binding]; other site 291272001730 zinc binding site [ion binding]; other site 291272001731 catalytic residues [active] 291272001732 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 291272001733 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 291272001734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291272001735 homodimer interface [polypeptide binding]; other site 291272001736 catalytic residue [active] 291272001737 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 291272001738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 291272001739 active site 291272001740 motif I; other site 291272001741 motif II; other site 291272001742 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 291272001743 putative active site pocket [active] 291272001744 4-fold oligomerization interface [polypeptide binding]; other site 291272001745 metal binding residues [ion binding]; metal-binding site 291272001746 3-fold/trimer interface [polypeptide binding]; other site 291272001747 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 291272001748 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 291272001749 putative active site [active] 291272001750 oxyanion strand; other site 291272001751 catalytic triad [active] 291272001752 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 291272001753 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 291272001754 catalytic residues [active] 291272001755 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 291272001756 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 291272001757 substrate binding site [chemical binding]; other site 291272001758 glutamase interaction surface [polypeptide binding]; other site 291272001759 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 291272001760 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 291272001761 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 291272001762 metal binding site [ion binding]; metal-binding site 291272001763 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 291272001764 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 291272001765 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 291272001766 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 291272001767 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 291272001768 active site 291272001769 HIGH motif; other site 291272001770 KMSKS motif; other site 291272001771 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 291272001772 tRNA binding surface [nucleotide binding]; other site 291272001773 anticodon binding site; other site 291272001774 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 291272001775 active site 291272001776 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 291272001777 5S rRNA interface [nucleotide binding]; other site 291272001778 CTC domain interface [polypeptide binding]; other site 291272001779 L16 interface [polypeptide binding]; other site 291272001780 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 291272001781 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 291272001782 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 291272001783 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 291272001784 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 291272001785 trimer interface [polypeptide binding]; other site 291272001786 eyelet of channel; other site 291272001787 DNA gyrase subunit A; Validated; Region: PRK05560 291272001788 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 291272001789 CAP-like domain; other site 291272001790 active site 291272001791 primary dimer interface [polypeptide binding]; other site 291272001792 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291272001793 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291272001794 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291272001795 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291272001796 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291272001797 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291272001798 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 291272001799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 291272001800 S-adenosylmethionine binding site [chemical binding]; other site 291272001801 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 291272001802 ATP cone domain; Region: ATP-cone; pfam03477 291272001803 Class I ribonucleotide reductase; Region: RNR_I; cd01679 291272001804 active site 291272001805 dimer interface [polypeptide binding]; other site 291272001806 catalytic residues [active] 291272001807 effector binding site; other site 291272001808 R2 peptide binding site; other site 291272001809 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 291272001810 dimer interface [polypeptide binding]; other site 291272001811 putative radical transfer pathway; other site 291272001812 diiron center [ion binding]; other site 291272001813 tyrosyl radical; other site 291272001814 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 291272001815 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 291272001816 catalytic loop [active] 291272001817 iron binding site [ion binding]; other site 291272001818 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 291272001819 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 291272001820 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 291272001821 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 291272001822 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 291272001823 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 291272001824 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 291272001825 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 291272001826 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 291272001827 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 291272001828 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 291272001829 4Fe-4S binding domain; Region: Fer4; pfam00037 291272001830 4Fe-4S binding domain; Region: Fer4; pfam00037 291272001831 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 291272001832 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 291272001833 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 291272001834 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 291272001835 catalytic loop [active] 291272001836 iron binding site [ion binding]; other site 291272001837 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 291272001838 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 291272001839 [4Fe-4S] binding site [ion binding]; other site 291272001840 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 291272001841 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 291272001842 SLBB domain; Region: SLBB; pfam10531 291272001843 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 291272001844 NADH dehydrogenase subunit E; Validated; Region: PRK07539 291272001845 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 291272001846 putative dimer interface [polypeptide binding]; other site 291272001847 [2Fe-2S] cluster binding site [ion binding]; other site 291272001848 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 291272001849 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 291272001850 NADH dehydrogenase subunit D; Validated; Region: PRK06075 291272001851 possible site of translation initiation 291272001852 alternate predicted RBS 291272001853 NADH dehydrogenase subunit B; Validated; Region: PRK06411 291272001854 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 291272001855 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 291272001856 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291272001857 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 291272001858 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 291272001859 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 291272001860 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 291272001861 dimerization interface 3.5A [polypeptide binding]; other site 291272001862 active site 291272001863 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 291272001864 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 291272001865 ligand binding site [chemical binding]; other site 291272001866 NAD binding site [chemical binding]; other site 291272001867 catalytic site [active] 291272001868 homodimer interface [polypeptide binding]; other site 291272001869 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 291272001870 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 291272001871 dimer interface [polypeptide binding]; other site 291272001872 active site 291272001873 HemK family putative methylases; Region: hemK_fam; TIGR00536 291272001874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 291272001875 S-adenosylmethionine binding site [chemical binding]; other site 291272001876 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 291272001877 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 291272001878 Tetramer interface [polypeptide binding]; other site 291272001879 active site 291272001880 FMN-binding site [chemical binding]; other site 291272001881 manganese transport protein MntH; Reviewed; Region: PRK00701 291272001882 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 291272001883 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 291272001884 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 291272001885 Nucleoside recognition; Region: Gate; pfam07670 291272001886 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 291272001887 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 291272001888 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291272001889 active site 291272001890 HIGH motif; other site 291272001891 nucleotide binding site [chemical binding]; other site 291272001892 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 291272001893 active site 291272001894 KMSKS motif; other site 291272001895 Ligase N family; Region: LIGANc; smart00532 291272001896 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 291272001897 nucleotide binding pocket [chemical binding]; other site 291272001898 K-X-D-G motif; other site 291272001899 catalytic site [active] 291272001900 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 291272001901 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 291272001902 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 291272001903 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 291272001904 dimer interface [polypeptide binding]; other site 291272001905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291272001906 catalytic residue [active] 291272001907 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 291272001908 dimerization domain swap beta strand [polypeptide binding]; other site 291272001909 regulatory protein interface [polypeptide binding]; other site 291272001910 active site 291272001911 regulatory phosphorylation site [posttranslational modification]; other site 291272001912 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 291272001913 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 291272001914 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 291272001915 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 291272001916 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 291272001917 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 291272001918 Walker A/P-loop; other site 291272001919 ATP binding site [chemical binding]; other site 291272001920 Q-loop/lid; other site 291272001921 ABC transporter signature motif; other site 291272001922 Walker B; other site 291272001923 D-loop; other site 291272001924 H-loop/switch region; other site 291272001925 TOBE-like domain; Region: TOBE_3; pfam12857 291272001926 sulfate transport protein; Provisional; Region: cysT; CHL00187 291272001927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 291272001928 dimer interface [polypeptide binding]; other site 291272001929 conserved gate region; other site 291272001930 putative PBP binding loops; other site 291272001931 ABC-ATPase subunit interface; other site 291272001932 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 291272001933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 291272001934 dimer interface [polypeptide binding]; other site 291272001935 conserved gate region; other site 291272001936 putative PBP binding loops; other site 291272001937 ABC-ATPase subunit interface; other site 291272001938 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 291272001939 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 291272001940 Class I aldolases; Region: Aldolase_Class_I; cl17187 291272001941 catalytic residue [active] 291272001942 transketolase; Reviewed; Region: PRK12753 291272001943 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 291272001944 TPP-binding site [chemical binding]; other site 291272001945 dimer interface [polypeptide binding]; other site 291272001946 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 291272001947 PYR/PP interface [polypeptide binding]; other site 291272001948 dimer interface [polypeptide binding]; other site 291272001949 TPP binding site [chemical binding]; other site 291272001950 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 291272001951 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 291272001952 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 291272001953 metal binding site [ion binding]; metal-binding site 291272001954 dimer interface [polypeptide binding]; other site 291272001955 lipoprotein; Provisional; Region: PRK11679 291272001956 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 291272001957 dihydrodipicolinate synthase; Region: dapA; TIGR00674 291272001958 dimer interface [polypeptide binding]; other site 291272001959 active site 291272001960 catalytic residue [active] 291272001961 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 291272001962 catalytic triad [active] 291272001963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 291272001964 active site 291272001965 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 291272001966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 291272001967 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 291272001968 UreF; Region: UreF; pfam01730 291272001969 urease subunit alpha; Reviewed; Region: ureC; PRK13207 291272001970 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 291272001971 subunit interactions [polypeptide binding]; other site 291272001972 active site 291272001973 flap region; other site 291272001974 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 291272001975 gamma-beta subunit interface [polypeptide binding]; other site 291272001976 alpha-beta subunit interface [polypeptide binding]; other site 291272001977 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 291272001978 alpha-gamma subunit interface [polypeptide binding]; other site 291272001979 beta-gamma subunit interface [polypeptide binding]; other site 291272001980 UreD urease accessory protein; Region: UreD; pfam01774 291272001981 GMP synthase; Reviewed; Region: guaA; PRK00074 291272001982 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 291272001983 AMP/PPi binding site [chemical binding]; other site 291272001984 candidate oxyanion hole; other site 291272001985 catalytic triad [active] 291272001986 potential glutamine specificity residues [chemical binding]; other site 291272001987 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 291272001988 ATP Binding subdomain [chemical binding]; other site 291272001989 Ligand Binding sites [chemical binding]; other site 291272001990 Dimerization subdomain; other site 291272001991 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 291272001992 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 291272001993 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 291272001994 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 291272001995 active site 291272001996 malate:quinone oxidoreductase; Validated; Region: PRK05257 291272001997 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 291272001998 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 291272001999 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 291272002000 G1 box; other site 291272002001 GTP/Mg2+ binding site [chemical binding]; other site 291272002002 Switch I region; other site 291272002003 G2 box; other site 291272002004 Switch II region; other site 291272002005 G3 box; other site 291272002006 G4 box; other site 291272002007 G5 box; other site 291272002008 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 291272002009 G1 box; other site 291272002010 GTP/Mg2+ binding site [chemical binding]; other site 291272002011 Switch I region; other site 291272002012 G2 box; other site 291272002013 G3 box; other site 291272002014 Switch II region; other site 291272002015 G4 box; other site 291272002016 G5 box; other site 291272002017 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 291272002018 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 291272002019 dimer interface [polypeptide binding]; other site 291272002020 motif 1; other site 291272002021 active site 291272002022 motif 2; other site 291272002023 motif 3; other site 291272002024 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 291272002025 anticodon binding site; other site 291272002026 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 291272002027 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 291272002028 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 291272002029 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 291272002030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 291272002031 FeS/SAM binding site; other site 291272002032 possible site of translation initiation 291272002033 alternate predicted RBS 291272002034 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 291272002035 active site 291272002036 multimer interface [polypeptide binding]; other site 291272002037 cysteine desulfurase; Provisional; Region: PRK14012 291272002038 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 291272002039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291272002040 catalytic residue [active] 291272002041 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 291272002042 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 291272002043 active site 291272002044 dimerization interface [polypeptide binding]; other site 291272002045 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 291272002046 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 291272002047 dimer interface [polypeptide binding]; other site 291272002048 active site 291272002049 glycine-pyridoxal phosphate binding site [chemical binding]; other site 291272002050 folate binding site [chemical binding]; other site 291272002051 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 291272002052 nucleoside/Zn binding site; other site 291272002053 dimer interface [polypeptide binding]; other site 291272002054 catalytic motif [active] 291272002055 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 291272002056 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 291272002057 active site 291272002058 hydrophilic channel; other site 291272002059 dimerization interface [polypeptide binding]; other site 291272002060 catalytic residues [active] 291272002061 active site lid [active] 291272002062 ribonuclease III; Reviewed; Region: rnc; PRK00102 291272002063 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 291272002064 dimerization interface [polypeptide binding]; other site 291272002065 active site 291272002066 metal binding site [ion binding]; metal-binding site 291272002067 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 291272002068 dsRNA binding site [nucleotide binding]; other site 291272002069 signal peptidase I; Provisional; Region: PRK10861 291272002070 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 291272002071 Catalytic site [active] 291272002072 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 291272002073 GTP-binding protein LepA; Provisional; Region: PRK05433 291272002074 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 291272002075 G1 box; other site 291272002076 putative GEF interaction site [polypeptide binding]; other site 291272002077 GTP/Mg2+ binding site [chemical binding]; other site 291272002078 Switch I region; other site 291272002079 G2 box; other site 291272002080 G3 box; other site 291272002081 Switch II region; other site 291272002082 G4 box; other site 291272002083 G5 box; other site 291272002084 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 291272002085 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 291272002086 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 291272002087 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 291272002088 ligand binding site [chemical binding]; other site 291272002089 active site 291272002090 UGI interface [polypeptide binding]; other site 291272002091 catalytic site [active] 291272002092 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 291272002093 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 291272002094 dimer interface [polypeptide binding]; other site 291272002095 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 291272002096 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 291272002097 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 291272002098 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 291272002099 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 291272002100 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 291272002101 putative coenzyme Q binding site [chemical binding]; other site 291272002102 possible site of translation initiation 291272002103 alternate predicted RBS 291272002104 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 291272002105 SmpB-tmRNA interface; other site 291272002106 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 291272002107 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 291272002108 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 291272002109 domain interface [polypeptide binding]; other site 291272002110 putative active site [active] 291272002111 catalytic site [active] 291272002112 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 291272002113 domain interface [polypeptide binding]; other site 291272002114 putative active site [active] 291272002115 catalytic site [active] 291272002116 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 291272002117 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 291272002118 purine monophosphate binding site [chemical binding]; other site 291272002119 dimer interface [polypeptide binding]; other site 291272002120 putative catalytic residues [active] 291272002121 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 291272002122 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 291272002123 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 291272002124 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 291272002125 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 291272002126 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 291272002127 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 291272002128 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 291272002129 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 291272002130 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 291272002131 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 291272002132 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 291272002133 DNA binding site [nucleotide binding] 291272002134 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 291272002135 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 291272002136 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 291272002137 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 291272002138 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 291272002139 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 291272002140 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 291272002141 RPB3 interaction site [polypeptide binding]; other site 291272002142 RPB1 interaction site [polypeptide binding]; other site 291272002143 RPB11 interaction site [polypeptide binding]; other site 291272002144 RPB10 interaction site [polypeptide binding]; other site 291272002145 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 291272002146 core dimer interface [polypeptide binding]; other site 291272002147 peripheral dimer interface [polypeptide binding]; other site 291272002148 L10 interface [polypeptide binding]; other site 291272002149 L11 interface [polypeptide binding]; other site 291272002150 putative EF-Tu interaction site [polypeptide binding]; other site 291272002151 putative EF-G interaction site [polypeptide binding]; other site 291272002152 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 291272002153 23S rRNA interface [nucleotide binding]; other site 291272002154 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 291272002155 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 291272002156 mRNA/rRNA interface [nucleotide binding]; other site 291272002157 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 291272002158 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 291272002159 23S rRNA interface [nucleotide binding]; other site 291272002160 L7/L12 interface [polypeptide binding]; other site 291272002161 putative thiostrepton binding site; other site 291272002162 L25 interface [polypeptide binding]; other site 291272002163 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 291272002164 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 291272002165 putative homodimer interface [polypeptide binding]; other site 291272002166 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 291272002167 heterodimer interface [polypeptide binding]; other site 291272002168 homodimer interface [polypeptide binding]; other site 291272002169 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 291272002170 elongation factor Tu; Reviewed; Region: PRK00049 291272002171 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 291272002172 G1 box; other site 291272002173 GEF interaction site [polypeptide binding]; other site 291272002174 GTP/Mg2+ binding site [chemical binding]; other site 291272002175 Switch I region; other site 291272002176 G2 box; other site 291272002177 G3 box; other site 291272002178 Switch II region; other site 291272002179 G4 box; other site 291272002180 G5 box; other site 291272002181 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 291272002182 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 291272002183 Antibiotic Binding Site [chemical binding]; other site 291272002184 elongation factor G; Reviewed; Region: PRK00007 291272002185 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 291272002186 G1 box; other site 291272002187 putative GEF interaction site [polypeptide binding]; other site 291272002188 GTP/Mg2+ binding site [chemical binding]; other site 291272002189 Switch I region; other site 291272002190 G2 box; other site 291272002191 G3 box; other site 291272002192 Switch II region; other site 291272002193 G4 box; other site 291272002194 G5 box; other site 291272002195 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 291272002196 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 291272002197 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 291272002198 30S ribosomal protein S7; Validated; Region: PRK05302 291272002199 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 291272002200 S17 interaction site [polypeptide binding]; other site 291272002201 S8 interaction site; other site 291272002202 16S rRNA interaction site [nucleotide binding]; other site 291272002203 streptomycin interaction site [chemical binding]; other site 291272002204 23S rRNA interaction site [nucleotide binding]; other site 291272002205 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 291272002206 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 291272002207 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 291272002208 glutamine binding [chemical binding]; other site 291272002209 catalytic triad [active] 291272002210 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 291272002211 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 291272002212 active site 291272002213 HIGH motif; other site 291272002214 dimer interface [polypeptide binding]; other site 291272002215 KMSKS motif; other site 291272002216 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 291272002217 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 291272002218 substrate binding site [chemical binding]; other site 291272002219 hexamer interface [polypeptide binding]; other site 291272002220 metal binding site [ion binding]; metal-binding site 291272002221 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 291272002222 active site 291272002223 dimer interface [polypeptide binding]; other site 291272002224 metal binding site [ion binding]; metal-binding site 291272002225 shikimate kinase; Reviewed; Region: aroK; PRK00131 291272002226 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 291272002227 ADP binding site [chemical binding]; other site 291272002228 magnesium binding site [ion binding]; other site 291272002229 putative shikimate binding site; other site 291272002230 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 291272002231 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 291272002232 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 291272002233 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 291272002234 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 291272002235 putative antibiotic transporter; Provisional; Region: PRK10739 291272002236 putative hydrolase; Provisional; Region: PRK10976 291272002237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 291272002238 active site 291272002239 motif I; other site 291272002240 motif II; other site 291272002241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 291272002242 motif II; other site 291272002243 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 291272002244 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 291272002245 Cl binding site [ion binding]; other site 291272002246 oligomer interface [polypeptide binding]; other site 291272002247 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 291272002248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 291272002249 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 291272002250 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 291272002251 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 291272002252 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 291272002253 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 291272002254 domain interfaces; other site 291272002255 active site 291272002256 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 291272002257 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 291272002258 active site 291272002259 transcription termination factor Rho; Provisional; Region: rho; PRK09376 291272002260 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 291272002261 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 291272002262 RNA binding site [nucleotide binding]; other site 291272002263 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 291272002264 multimer interface [polypeptide binding]; other site 291272002265 Walker A motif; other site 291272002266 ATP binding site [chemical binding]; other site 291272002267 Walker B motif; other site 291272002268 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 291272002269 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 291272002270 catalytic residues [active] 291272002271 ketol-acid reductoisomerase; Validated; Region: PRK05225 291272002272 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 291272002273 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 291272002274 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 291272002275 threonine dehydratase; Reviewed; Region: PRK09224 291272002276 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 291272002277 tetramer interface [polypeptide binding]; other site 291272002278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291272002279 catalytic residue [active] 291272002280 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 291272002281 putative Ile/Val binding site [chemical binding]; other site 291272002282 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 291272002283 putative Ile/Val binding site [chemical binding]; other site 291272002284 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 291272002285 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 291272002286 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 291272002287 homodimer interface [polypeptide binding]; other site 291272002288 substrate-cofactor binding pocket; other site 291272002289 catalytic residue [active] 291272002290 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 291272002291 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 291272002292 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 291272002293 PYR/PP interface [polypeptide binding]; other site 291272002294 dimer interface [polypeptide binding]; other site 291272002295 TPP binding site [chemical binding]; other site 291272002296 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 291272002297 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 291272002298 TPP-binding site [chemical binding]; other site 291272002299 dimer interface [polypeptide binding]; other site 291272002300 glutamate racemase; Provisional; Region: PRK00865 291272002301 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 291272002302 FAD binding site [chemical binding]; other site 291272002303 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 291272002304 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 291272002305 homodimer interface [polypeptide binding]; other site 291272002306 substrate-cofactor binding pocket; other site 291272002307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291272002308 catalytic residue [active] 291272002309 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 291272002310 ferredoxin-NADP reductase; Provisional; Region: PRK10926 291272002311 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 291272002312 FAD binding pocket [chemical binding]; other site 291272002313 FAD binding motif [chemical binding]; other site 291272002314 phosphate binding motif [ion binding]; other site 291272002315 beta-alpha-beta structure motif; other site 291272002316 NAD binding pocket [chemical binding]; other site 291272002317 triosephosphate isomerase; Provisional; Region: PRK14567 291272002318 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 291272002319 substrate binding site [chemical binding]; other site 291272002320 dimer interface [polypeptide binding]; other site 291272002321 catalytic triad [active] 291272002322 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 291272002323 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 291272002324 active site 291272002325 ADP/pyrophosphate binding site [chemical binding]; other site 291272002326 dimerization interface [polypeptide binding]; other site 291272002327 allosteric effector site; other site 291272002328 fructose-1,6-bisphosphate binding site; other site 291272002329 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 291272002330 serine O-acetyltransferase; Region: cysE; TIGR01172 291272002331 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 291272002332 trimer interface [polypeptide binding]; other site 291272002333 active site 291272002334 substrate binding site [chemical binding]; other site 291272002335 CoA binding site [chemical binding]; other site 291272002336 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 291272002337 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 291272002338 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 291272002339 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 291272002340 SecA binding site; other site 291272002341 Preprotein binding site; other site 291272002342 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 291272002343 GSH binding site [chemical binding]; other site 291272002344 catalytic residues [active] 291272002345 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 291272002346 active site residue [active] 291272002347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291272002348 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 291272002349 NAD(P) binding site [chemical binding]; other site 291272002350 active site 291272002351 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 291272002352 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 291272002353 putative active site [active] 291272002354 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 291272002355 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 291272002356 putative active site [active] 291272002357 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 291272002358 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 291272002359 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291272002360 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 291272002361 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 291272002362 active site 291272002363 (T/H)XGH motif; other site 291272002364 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 291272002365 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 291272002366 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 291272002367 Flavoprotein; Region: Flavoprotein; pfam02441 291272002368 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 291272002369 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 291272002370 trimer interface [polypeptide binding]; other site 291272002371 active site 291272002372 hypothetical protein; Provisional; Region: PRK11820 291272002373 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 291272002374 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 291272002375 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 291272002376 MarR family; Region: MarR; pfam01047 291272002377 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 291272002378 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 291272002379 catalytic site [active] 291272002380 G-X2-G-X-G-K; other site 291272002381 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 291272002382 glutamine synthetase; Provisional; Region: glnA; PRK09469 291272002383 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 291272002384 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 291272002385 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 291272002386 G1 box; other site 291272002387 GTP/Mg2+ binding site [chemical binding]; other site 291272002388 Switch I region; other site 291272002389 G2 box; other site 291272002390 G3 box; other site 291272002391 Switch II region; other site 291272002392 G4 box; other site 291272002393 G5 box; other site 291272002394 DNA polymerase I; Provisional; Region: PRK05755 291272002395 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 291272002396 active site 291272002397 metal binding site 1 [ion binding]; metal-binding site 291272002398 putative 5' ssDNA interaction site; other site 291272002399 metal binding site 3; metal-binding site 291272002400 metal binding site 2 [ion binding]; metal-binding site 291272002401 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 291272002402 putative DNA binding site [nucleotide binding]; other site 291272002403 putative metal binding site [ion binding]; other site 291272002404 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 291272002405 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 291272002406 active site 291272002407 DNA binding site [nucleotide binding] 291272002408 catalytic site [active] 291272002409 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 291272002410 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 291272002411 catalytic residues [active] 291272002412 hinge region; other site 291272002413 alpha helical domain; other site 291272002414 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 291272002415 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 291272002416 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 291272002417 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 291272002418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 291272002419 S-adenosylmethionine binding site [chemical binding]; other site 291272002420 DNA recombination protein RmuC; Provisional; Region: PRK10361 291272002421 RmuC family; Region: RmuC; pfam02646 291272002422 uridine phosphorylase; Provisional; Region: PRK11178 291272002423 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 291272002424 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 291272002425 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 291272002426 THF binding site; other site 291272002427 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 291272002428 substrate binding site [chemical binding]; other site 291272002429 THF binding site; other site 291272002430 zinc-binding site [ion binding]; other site 291272002431 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 291272002432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291272002433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 291272002434 DNA binding residues [nucleotide binding] 291272002435 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 291272002436 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 291272002437 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 291272002438 P loop; other site 291272002439 GTP binding site [chemical binding]; other site 291272002440 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 291272002441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 291272002442 S-adenosylmethionine binding site [chemical binding]; other site 291272002443 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 291272002444 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 291272002445 active site 291272002446 dimer interface [polypeptide binding]; other site 291272002447 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 291272002448 dimer interface [polypeptide binding]; other site 291272002449 active site 291272002450 homoserine O-succinyltransferase; Provisional; Region: PRK05368 291272002451 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 291272002452 proposed active site lysine [active] 291272002453 conserved cys residue [active]