-- dump date 20140619_024138 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1234603000001 recombinase A; Provisional; Region: recA; PRK09354 1234603000002 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1234603000003 hexamer interface [polypeptide binding]; other site 1234603000004 Walker A motif; other site 1234603000005 ATP binding site [chemical binding]; other site 1234603000006 Walker B motif; other site 1234603000007 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1234603000008 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1234603000009 motif 1; other site 1234603000010 active site 1234603000011 motif 2; other site 1234603000012 motif 3; other site 1234603000013 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1234603000014 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1234603000015 DHHA1 domain; Region: DHHA1; pfam02272 1234603000016 carbon storage regulator; Provisional; Region: PRK01712 1234603000017 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1234603000018 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1234603000019 putative dimer interface [polypeptide binding]; other site 1234603000020 putative anticodon binding site; other site 1234603000021 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1234603000022 homodimer interface [polypeptide binding]; other site 1234603000023 motif 1; other site 1234603000024 motif 2; other site 1234603000025 active site 1234603000026 motif 3; other site 1234603000027 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1234603000028 homodimer interface [polypeptide binding]; other site 1234603000029 substrate-cofactor binding pocket; other site 1234603000030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234603000031 catalytic residue [active] 1234603000032 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1234603000033 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1234603000034 RNA binding site [nucleotide binding]; other site 1234603000035 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1234603000036 RNA binding site [nucleotide binding]; other site 1234603000037 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1234603000038 RNA binding site [nucleotide binding]; other site 1234603000039 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1234603000040 RNA binding site [nucleotide binding]; other site 1234603000041 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1234603000042 RNA binding site [nucleotide binding]; other site 1234603000043 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1234603000044 RNA binding site [nucleotide binding]; other site 1234603000045 peroxidase; Provisional; Region: PRK15000 1234603000046 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1234603000047 dimer interface [polypeptide binding]; other site 1234603000048 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1234603000049 catalytic triad [active] 1234603000050 peroxidatic and resolving cysteines [active] 1234603000051 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1234603000052 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1234603000053 serine endoprotease; Provisional; Region: PRK10139 1234603000054 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1234603000055 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1234603000056 protein binding site [polypeptide binding]; other site 1234603000057 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1234603000058 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1234603000059 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1234603000060 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1234603000061 dimer interface [polypeptide binding]; other site 1234603000062 motif 1; other site 1234603000063 active site 1234603000064 motif 2; other site 1234603000065 motif 3; other site 1234603000066 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1234603000067 anticodon binding site; other site 1234603000068 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1234603000069 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1234603000070 Trp docking motif [polypeptide binding]; other site 1234603000071 active site 1234603000072 GTP-binding protein Der; Reviewed; Region: PRK00093 1234603000073 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1234603000074 G1 box; other site 1234603000075 GTP/Mg2+ binding site [chemical binding]; other site 1234603000076 Switch I region; other site 1234603000077 G2 box; other site 1234603000078 Switch II region; other site 1234603000079 G3 box; other site 1234603000080 G4 box; other site 1234603000081 G5 box; other site 1234603000082 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1234603000083 G1 box; other site 1234603000084 GTP/Mg2+ binding site [chemical binding]; other site 1234603000085 Switch I region; other site 1234603000086 G2 box; other site 1234603000087 G3 box; other site 1234603000088 Switch II region; other site 1234603000089 G4 box; other site 1234603000090 G5 box; other site 1234603000091 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1234603000092 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1234603000093 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1234603000094 generic binding surface II; other site 1234603000095 ssDNA binding site; other site 1234603000096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1234603000097 ATP binding site [chemical binding]; other site 1234603000098 putative Mg++ binding site [ion binding]; other site 1234603000099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1234603000100 nucleotide binding region [chemical binding]; other site 1234603000101 ATP-binding site [chemical binding]; other site 1234603000102 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1234603000103 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1234603000104 Walker A/P-loop; other site 1234603000105 ATP binding site [chemical binding]; other site 1234603000106 Q-loop/lid; other site 1234603000107 ABC transporter signature motif; other site 1234603000108 Walker B; other site 1234603000109 D-loop; other site 1234603000110 H-loop/switch region; other site 1234603000111 OstA-like protein; Region: OstA; cl00844 1234603000112 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1234603000113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1234603000114 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1234603000115 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1234603000116 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1234603000117 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1234603000118 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1234603000119 dimer interface [polypeptide binding]; other site 1234603000120 TPP-binding site [chemical binding]; other site 1234603000121 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1234603000122 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1234603000123 E3 interaction surface; other site 1234603000124 lipoyl attachment site [posttranslational modification]; other site 1234603000125 e3 binding domain; Region: E3_binding; pfam02817 1234603000126 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1234603000127 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1234603000128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1234603000129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1234603000130 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1234603000131 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1234603000132 CPxP motif; other site 1234603000133 siroheme synthase; Provisional; Region: cysG; PRK10637 1234603000134 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1234603000135 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1234603000136 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1234603000137 active site 1234603000138 SAM binding site [chemical binding]; other site 1234603000139 homodimer interface [polypeptide binding]; other site 1234603000140 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1234603000141 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1234603000142 Active Sites [active] 1234603000143 sulfite reductase subunit beta; Provisional; Region: PRK13504 1234603000144 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1234603000145 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1234603000146 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1234603000147 Flavodoxin; Region: Flavodoxin_1; pfam00258 1234603000148 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1234603000149 FAD binding pocket [chemical binding]; other site 1234603000150 FAD binding motif [chemical binding]; other site 1234603000151 catalytic residues [active] 1234603000152 NAD binding pocket [chemical binding]; other site 1234603000153 phosphate binding motif [ion binding]; other site 1234603000154 beta-alpha-beta structure motif; other site 1234603000155 enolase; Provisional; Region: eno; PRK00077 1234603000156 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1234603000157 dimer interface [polypeptide binding]; other site 1234603000158 metal binding site [ion binding]; metal-binding site 1234603000159 substrate binding pocket [chemical binding]; other site 1234603000160 DNA polymerase I; Provisional; Region: PRK05755 1234603000161 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1234603000162 active site 1234603000163 metal binding site 1 [ion binding]; metal-binding site 1234603000164 putative 5' ssDNA interaction site; other site 1234603000165 metal binding site 3; metal-binding site 1234603000166 metal binding site 2 [ion binding]; metal-binding site 1234603000167 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1234603000168 putative DNA binding site [nucleotide binding]; other site 1234603000169 putative metal binding site [ion binding]; other site 1234603000170 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1234603000171 active site 1234603000172 catalytic site [active] 1234603000173 substrate binding site [chemical binding]; other site 1234603000174 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1234603000175 active site 1234603000176 DNA binding site [nucleotide binding] 1234603000177 catalytic site [active] 1234603000178 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1234603000179 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1234603000180 FMN binding site [chemical binding]; other site 1234603000181 active site 1234603000182 catalytic residues [active] 1234603000183 substrate binding site [chemical binding]; other site 1234603000184 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1234603000185 dimer interface [polypeptide binding]; other site 1234603000186 motif 1; other site 1234603000187 active site 1234603000188 motif 2; other site 1234603000189 motif 3; other site 1234603000190 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1234603000191 DALR anticodon binding domain; Region: DALR_1; pfam05746 1234603000192 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1234603000193 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1234603000194 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1234603000195 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1234603000196 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1234603000197 hypothetical protein; Provisional; Region: PRK11820 1234603000198 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1234603000199 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1234603000200 MraW methylase family; Region: Methyltransf_5; pfam01795 1234603000201 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1234603000202 Cell division protein FtsL; Region: FtsL; cl11433 1234603000203 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1234603000204 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1234603000205 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1234603000206 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1234603000207 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1234603000208 Mg++ binding site [ion binding]; other site 1234603000209 putative catalytic motif [active] 1234603000210 putative substrate binding site [chemical binding]; other site 1234603000211 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1234603000212 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1234603000213 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1234603000214 active site 1234603000215 homodimer interface [polypeptide binding]; other site 1234603000216 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1234603000217 Cell division protein FtsA; Region: FtsA; smart00842 1234603000218 Cell division protein FtsA; Region: FtsA; pfam14450 1234603000219 cell division protein FtsZ; Validated; Region: PRK09330 1234603000220 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1234603000221 nucleotide binding site [chemical binding]; other site 1234603000222 SulA interaction site; other site 1234603000223 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1234603000224 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1234603000225 Protein of unknown function (DUF721); Region: DUF721; cl02324 1234603000226 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1234603000227 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1234603000228 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1234603000229 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1234603000230 dimer interface [polypeptide binding]; other site 1234603000231 PYR/PP interface [polypeptide binding]; other site 1234603000232 TPP binding site [chemical binding]; other site 1234603000233 substrate binding site [chemical binding]; other site 1234603000234 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1234603000235 Domain of unknown function; Region: EKR; smart00890 1234603000236 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1234603000237 4Fe-4S binding domain; Region: Fer4; pfam00037 1234603000238 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1234603000239 TPP-binding site [chemical binding]; other site 1234603000240 dimer interface [polypeptide binding]; other site 1234603000241 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1234603000242 Phosphoglycerate kinase; Region: PGK; pfam00162 1234603000243 substrate binding site [chemical binding]; other site 1234603000244 hinge regions; other site 1234603000245 ADP binding site [chemical binding]; other site 1234603000246 catalytic site [active] 1234603000247 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1234603000248 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1234603000249 active site 1234603000250 intersubunit interface [polypeptide binding]; other site 1234603000251 zinc binding site [ion binding]; other site 1234603000252 Na+ binding site [ion binding]; other site 1234603000253 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1234603000254 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1234603000255 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1234603000256 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1234603000257 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1234603000258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1234603000259 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1234603000260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1234603000261 DNA binding residues [nucleotide binding] 1234603000262 DNA primase; Validated; Region: dnaG; PRK05667 1234603000263 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1234603000264 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1234603000265 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1234603000266 active site 1234603000267 metal binding site [ion binding]; metal-binding site 1234603000268 interdomain interaction site; other site 1234603000269 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1234603000270 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1234603000271 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1234603000272 UGMP family protein; Validated; Region: PRK09604 1234603000273 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1234603000274 translation elongation factor P; Region: efp; TIGR00038 1234603000275 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1234603000276 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1234603000277 RNA binding site [nucleotide binding]; other site 1234603000278 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1234603000279 RNA binding site [nucleotide binding]; other site 1234603000280 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1234603000281 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1234603000282 active site 1234603000283 trimer interface [polypeptide binding]; other site 1234603000284 dimer interface [polypeptide binding]; other site 1234603000285 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1234603000286 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1234603000287 carboxyltransferase (CT) interaction site; other site 1234603000288 biotinylation site [posttranslational modification]; other site 1234603000289 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1234603000290 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1234603000291 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1234603000292 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1234603000293 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1234603000294 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1234603000295 putative tRNA-binding site [nucleotide binding]; other site 1234603000296 B3/4 domain; Region: B3_4; pfam03483 1234603000297 tRNA synthetase B5 domain; Region: B5; smart00874 1234603000298 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1234603000299 dimer interface [polypeptide binding]; other site 1234603000300 motif 1; other site 1234603000301 motif 3; other site 1234603000302 motif 2; other site 1234603000303 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1234603000304 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1234603000305 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1234603000306 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1234603000307 dimer interface [polypeptide binding]; other site 1234603000308 motif 1; other site 1234603000309 active site 1234603000310 motif 2; other site 1234603000311 motif 3; other site 1234603000312 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1234603000313 23S rRNA binding site [nucleotide binding]; other site 1234603000314 L21 binding site [polypeptide binding]; other site 1234603000315 L13 binding site [polypeptide binding]; other site 1234603000316 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1234603000317 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1234603000318 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1234603000319 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1234603000320 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1234603000321 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1234603000322 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1234603000323 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1234603000324 active site 1234603000325 dimer interface [polypeptide binding]; other site 1234603000326 motif 1; other site 1234603000327 motif 2; other site 1234603000328 motif 3; other site 1234603000329 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1234603000330 anticodon binding site; other site 1234603000331 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1234603000332 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1234603000333 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1234603000334 shikimate binding site; other site 1234603000335 NAD(P) binding site [chemical binding]; other site 1234603000336 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1234603000337 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1234603000338 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1234603000339 Septum formation initiator; Region: DivIC; cl17659 1234603000340 hypothetical protein; Provisional; Region: PRK11027 1234603000341 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1234603000342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1234603000343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1234603000344 DNA binding residues [nucleotide binding] 1234603000345 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1234603000346 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1234603000347 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1234603000348 P loop; other site 1234603000349 GTP binding site [chemical binding]; other site 1234603000350 GTP-binding protein YchF; Reviewed; Region: PRK09601 1234603000351 YchF GTPase; Region: YchF; cd01900 1234603000352 G1 box; other site 1234603000353 GTP/Mg2+ binding site [chemical binding]; other site 1234603000354 Switch I region; other site 1234603000355 G2 box; other site 1234603000356 Switch II region; other site 1234603000357 G3 box; other site 1234603000358 G4 box; other site 1234603000359 G5 box; other site 1234603000360 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1234603000361 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1234603000362 putative active site [active] 1234603000363 catalytic residue [active] 1234603000364 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1234603000365 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1234603000366 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1234603000367 active site 1234603000368 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1234603000369 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1234603000370 RF-1 domain; Region: RF-1; pfam00472 1234603000371 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1234603000372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1234603000373 S-adenosylmethionine binding site [chemical binding]; other site 1234603000374 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1234603000375 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1234603000376 active site 1234603000377 dimerization interface [polypeptide binding]; other site 1234603000378 cysteine desulfurase; Provisional; Region: PRK14012 1234603000379 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1234603000380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1234603000381 catalytic residue [active] 1234603000382 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1234603000383 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1234603000384 active site 1234603000385 hydrophilic channel; other site 1234603000386 dimerization interface [polypeptide binding]; other site 1234603000387 catalytic residues [active] 1234603000388 active site lid [active] 1234603000389 protein disaggregation chaperone; Provisional; Region: PRK10865 1234603000390 Clp amino terminal domain; Region: Clp_N; pfam02861 1234603000391 Clp amino terminal domain; Region: Clp_N; pfam02861 1234603000392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1234603000393 Walker A motif; other site 1234603000394 ATP binding site [chemical binding]; other site 1234603000395 Walker B motif; other site 1234603000396 arginine finger; other site 1234603000397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1234603000398 Walker A motif; other site 1234603000399 ATP binding site [chemical binding]; other site 1234603000400 Walker B motif; other site 1234603000401 arginine finger; other site 1234603000402 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1234603000403 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1234603000404 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1234603000405 RNA binding surface [nucleotide binding]; other site 1234603000406 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1234603000407 active site 1234603000408 peptidase PmbA; Provisional; Region: PRK11040 1234603000409 Putative exonuclease, RdgC; Region: RdgC; pfam04381 1234603000410 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 1234603000411 putative global regulator; Reviewed; Region: PRK09559 1234603000412 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1234603000413 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1234603000414 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1234603000415 putative active site [active] 1234603000416 Ap4A binding site [chemical binding]; other site 1234603000417 nudix motif; other site 1234603000418 putative metal binding site [ion binding]; other site 1234603000419 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1234603000420 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1234603000421 penicillin-binding protein 2; Provisional; Region: PRK10795 1234603000422 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1234603000423 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1234603000424 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1234603000425 HemK family putative methylases; Region: hemK_fam; TIGR00536 1234603000426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1234603000427 S-adenosylmethionine binding site [chemical binding]; other site 1234603000428 Stringent starvation protein B; Region: SspB; cl01120 1234603000429 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1234603000430 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1234603000431 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1234603000432 trimer interface [polypeptide binding]; other site 1234603000433 active site 1234603000434 substrate binding site [chemical binding]; other site 1234603000435 CoA binding site [chemical binding]; other site 1234603000436 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1234603000437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1234603000438 active site 1234603000439 phosphorylation site [posttranslational modification] 1234603000440 intermolecular recognition site; other site 1234603000441 dimerization interface [polypeptide binding]; other site 1234603000442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1234603000443 DNA binding site [nucleotide binding] 1234603000444 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1234603000445 triosephosphate isomerase; Provisional; Region: PRK14567 1234603000446 substrate binding site [chemical binding]; other site 1234603000447 dimer interface [polypeptide binding]; other site 1234603000448 catalytic triad [active] 1234603000449 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1234603000450 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1234603000451 active site 1234603000452 ADP/pyrophosphate binding site [chemical binding]; other site 1234603000453 dimerization interface [polypeptide binding]; other site 1234603000454 allosteric effector site; other site 1234603000455 fructose-1,6-bisphosphate binding site; other site 1234603000456 transketolase; Reviewed; Region: PRK12753 1234603000457 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1234603000458 TPP-binding site [chemical binding]; other site 1234603000459 dimer interface [polypeptide binding]; other site 1234603000460 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1234603000461 PYR/PP interface [polypeptide binding]; other site 1234603000462 dimer interface [polypeptide binding]; other site 1234603000463 TPP binding site [chemical binding]; other site 1234603000464 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1234603000465 outer membrane lipoprotein; Provisional; Region: PRK11023 1234603000466 BON domain; Region: BON; pfam04972 1234603000467 BON domain; Region: BON; cl02771 1234603000468 metal-binding heat shock protein; Provisional; Region: PRK00016 1234603000469 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1234603000470 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1234603000471 dimer interface [polypeptide binding]; other site 1234603000472 motif 1; other site 1234603000473 active site 1234603000474 motif 2; other site 1234603000475 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1234603000476 putative deacylase active site [active] 1234603000477 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1234603000478 active site 1234603000479 motif 3; other site 1234603000480 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1234603000481 anticodon binding site; other site 1234603000482 argininosuccinate lyase; Provisional; Region: PRK04833 1234603000483 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1234603000484 active sites [active] 1234603000485 tetramer interface [polypeptide binding]; other site 1234603000486 superoxide dismutase; Provisional; Region: PRK10925 1234603000487 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1234603000488 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1234603000489 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1234603000490 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1234603000491 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1234603000492 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1234603000493 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1234603000494 active site 1234603000495 HIGH motif; other site 1234603000496 KMSK motif region; other site 1234603000497 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1234603000498 tRNA binding surface [nucleotide binding]; other site 1234603000499 anticodon binding site; other site 1234603000500 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1234603000501 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1234603000502 active site 1234603000503 interdomain interaction site; other site 1234603000504 putative metal-binding site [ion binding]; other site 1234603000505 nucleotide binding site [chemical binding]; other site 1234603000506 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1234603000507 domain I; other site 1234603000508 DNA binding groove [nucleotide binding] 1234603000509 phosphate binding site [ion binding]; other site 1234603000510 domain II; other site 1234603000511 domain III; other site 1234603000512 nucleotide binding site [chemical binding]; other site 1234603000513 catalytic site [active] 1234603000514 domain IV; other site 1234603000515 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1234603000516 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1234603000517 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1234603000518 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1234603000519 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1234603000520 nucleoside/Zn binding site; other site 1234603000521 dimer interface [polypeptide binding]; other site 1234603000522 catalytic motif [active] 1234603000523 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1234603000524 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1234603000525 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1234603000526 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 1234603000527 GTP1/OBG; Region: GTP1_OBG; pfam01018 1234603000528 Obg GTPase; Region: Obg; cd01898 1234603000529 G1 box; other site 1234603000530 GTP/Mg2+ binding site [chemical binding]; other site 1234603000531 Switch I region; other site 1234603000532 G2 box; other site 1234603000533 G3 box; other site 1234603000534 Switch II region; other site 1234603000535 G4 box; other site 1234603000536 G5 box; other site 1234603000537 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1234603000538 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1234603000539 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1234603000540 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1234603000541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1234603000542 S-adenosylmethionine binding site [chemical binding]; other site 1234603000543 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1234603000544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1234603000545 Walker A motif; other site 1234603000546 ATP binding site [chemical binding]; other site 1234603000547 Walker B motif; other site 1234603000548 arginine finger; other site 1234603000549 Peptidase family M41; Region: Peptidase_M41; pfam01434 1234603000550 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1234603000551 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1234603000552 NusA N-terminal domain; Region: NusA_N; pfam08529 1234603000553 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1234603000554 RNA binding site [nucleotide binding]; other site 1234603000555 homodimer interface [polypeptide binding]; other site 1234603000556 NusA-like KH domain; Region: KH_5; pfam13184 1234603000557 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1234603000558 G-X-X-G motif; other site 1234603000559 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1234603000560 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1234603000561 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1234603000562 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1234603000563 translation initiation factor IF-2; Region: IF-2; TIGR00487 1234603000564 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1234603000565 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1234603000566 G1 box; other site 1234603000567 putative GEF interaction site [polypeptide binding]; other site 1234603000568 GTP/Mg2+ binding site [chemical binding]; other site 1234603000569 Switch I region; other site 1234603000570 G2 box; other site 1234603000571 G3 box; other site 1234603000572 Switch II region; other site 1234603000573 G4 box; other site 1234603000574 G5 box; other site 1234603000575 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1234603000576 Translation-initiation factor 2; Region: IF-2; pfam11987 1234603000577 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1234603000578 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1234603000579 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1234603000580 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1234603000581 RNA binding site [nucleotide binding]; other site 1234603000582 active site 1234603000583 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1234603000584 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1234603000585 16S/18S rRNA binding site [nucleotide binding]; other site 1234603000586 S13e-L30e interaction site [polypeptide binding]; other site 1234603000587 25S rRNA binding site [nucleotide binding]; other site 1234603000588 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1234603000589 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1234603000590 RNase E interface [polypeptide binding]; other site 1234603000591 trimer interface [polypeptide binding]; other site 1234603000592 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1234603000593 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1234603000594 RNase E interface [polypeptide binding]; other site 1234603000595 trimer interface [polypeptide binding]; other site 1234603000596 active site 1234603000597 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1234603000598 putative nucleic acid binding region [nucleotide binding]; other site 1234603000599 G-X-X-G motif; other site 1234603000600 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1234603000601 RNA binding site [nucleotide binding]; other site 1234603000602 domain interface; other site 1234603000603 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1234603000604 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1234603000605 ATP binding site [chemical binding]; other site 1234603000606 Mg++ binding site [ion binding]; other site 1234603000607 motif III; other site 1234603000608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1234603000609 nucleotide binding region [chemical binding]; other site 1234603000610 ATP-binding site [chemical binding]; other site 1234603000611 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1234603000612 putative RNA binding site [nucleotide binding]; other site 1234603000613 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1234603000614 dimerization domain swap beta strand [polypeptide binding]; other site 1234603000615 regulatory protein interface [polypeptide binding]; other site 1234603000616 active site 1234603000617 regulatory phosphorylation site [posttranslational modification]; other site 1234603000618 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1234603000619 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1234603000620 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1234603000621 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1234603000622 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1234603000623 23S rRNA interface [nucleotide binding]; other site 1234603000624 L3 interface [polypeptide binding]; other site 1234603000625 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1234603000626 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1234603000627 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1234603000628 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1234603000629 putative active site [active] 1234603000630 catalytic site [active] 1234603000631 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1234603000632 putative active site [active] 1234603000633 catalytic site [active] 1234603000634 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1234603000635 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1234603000636 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1234603000637 RimM N-terminal domain; Region: RimM; pfam01782 1234603000638 PRC-barrel domain; Region: PRC; pfam05239 1234603000639 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1234603000640 signal recognition particle protein; Provisional; Region: PRK10867 1234603000641 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1234603000642 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1234603000643 P loop; other site 1234603000644 GTP binding site [chemical binding]; other site 1234603000645 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1234603000646 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1234603000647 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1234603000648 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1234603000649 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1234603000650 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1234603000651 catalytic residue [active] 1234603000652 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1234603000653 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1234603000654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1234603000655 S-adenosylmethionine binding site [chemical binding]; other site 1234603000656 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1234603000657 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1234603000658 dimer interface [polypeptide binding]; other site 1234603000659 active site 1234603000660 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1234603000661 active site 1234603000662 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1234603000663 rRNA interaction site [nucleotide binding]; other site 1234603000664 S8 interaction site; other site 1234603000665 putative laminin-1 binding site; other site 1234603000666 elongation factor Ts; Provisional; Region: tsf; PRK09377 1234603000667 UBA/TS-N domain; Region: UBA; pfam00627 1234603000668 Elongation factor TS; Region: EF_TS; pfam00889 1234603000669 Elongation factor TS; Region: EF_TS; pfam00889 1234603000670 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1234603000671 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1234603000672 hinge region; other site 1234603000673 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1234603000674 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1234603000675 catalytic residue [active] 1234603000676 putative FPP diphosphate binding site; other site 1234603000677 putative FPP binding hydrophobic cleft; other site 1234603000678 dimer interface [polypeptide binding]; other site 1234603000679 putative IPP diphosphate binding site; other site 1234603000680 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1234603000681 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1234603000682 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1234603000683 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1234603000684 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1234603000685 Surface antigen; Region: Bac_surface_Ag; pfam01103 1234603000686 periplasmic chaperone; Provisional; Region: PRK10780 1234603000687 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1234603000688 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1234603000689 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1234603000690 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1234603000691 trimer interface [polypeptide binding]; other site 1234603000692 active site 1234603000693 UDP-GlcNAc binding site [chemical binding]; other site 1234603000694 lipid binding site [chemical binding]; lipid-binding site 1234603000695 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1234603000696 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1234603000697 active site 1234603000698 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1234603000699 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1234603000700 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1234603000701 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1234603000702 putative active site [active] 1234603000703 putative PHP Thumb interface [polypeptide binding]; other site 1234603000704 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1234603000705 generic binding surface II; other site 1234603000706 generic binding surface I; other site 1234603000707 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1234603000708 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1234603000709 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1234603000710 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1234603000711 active site 1234603000712 HIGH motif; other site 1234603000713 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1234603000714 active site 1234603000715 KMSKS motif; other site 1234603000716 heat shock protein HtpX; Provisional; Region: PRK05457 1234603000717 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1234603000718 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1234603000719 oligomer interface [polypeptide binding]; other site 1234603000720 active site residues [active] 1234603000721 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1234603000722 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1234603000723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1234603000724 Walker A motif; other site 1234603000725 ATP binding site [chemical binding]; other site 1234603000726 Walker B motif; other site 1234603000727 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1234603000728 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1234603000729 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1234603000730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1234603000731 Walker A motif; other site 1234603000732 ATP binding site [chemical binding]; other site 1234603000733 Walker B motif; other site 1234603000734 arginine finger; other site 1234603000735 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1234603000736 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1234603000737 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1234603000738 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1234603000739 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1234603000740 putative active site [active] 1234603000741 substrate binding site [chemical binding]; other site 1234603000742 putative cosubstrate binding site; other site 1234603000743 catalytic site [active] 1234603000744 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1234603000745 substrate binding site [chemical binding]; other site 1234603000746 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1234603000747 active site 1234603000748 catalytic residues [active] 1234603000749 metal binding site [ion binding]; metal-binding site 1234603000750 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1234603000751 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1234603000752 active site 1234603000753 HIGH motif; other site 1234603000754 KMSKS motif; other site 1234603000755 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1234603000756 anticodon binding site; other site 1234603000757 tRNA binding surface [nucleotide binding]; other site 1234603000758 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1234603000759 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1234603000760 active site 1234603000761 ATP-binding site [chemical binding]; other site 1234603000762 pantoate-binding site; other site 1234603000763 HXXH motif; other site 1234603000764 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1234603000765 oligomerization interface [polypeptide binding]; other site 1234603000766 active site 1234603000767 metal binding site [ion binding]; metal-binding site 1234603000768 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1234603000769 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1234603000770 active site 1234603000771 NTP binding site [chemical binding]; other site 1234603000772 metal binding triad [ion binding]; metal-binding site 1234603000773 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1234603000774 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1234603000775 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1234603000776 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1234603000777 DHH family; Region: DHH; pfam01368 1234603000778 DHHA1 domain; Region: DHHA1; pfam02272 1234603000779 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1234603000780 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1234603000781 RF-1 domain; Region: RF-1; pfam00472 1234603000782 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1234603000783 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1234603000784 dimer interface [polypeptide binding]; other site 1234603000785 putative anticodon binding site; other site 1234603000786 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1234603000787 motif 1; other site 1234603000788 active site 1234603000789 motif 2; other site 1234603000790 motif 3; other site 1234603000791 shikimate kinase; Reviewed; Region: aroK; PRK00131 1234603000792 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1234603000793 ADP binding site [chemical binding]; other site 1234603000794 magnesium binding site [ion binding]; other site 1234603000795 putative shikimate binding site; other site 1234603000796 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1234603000797 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 1234603000798 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1234603000799 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1234603000800 Ligand Binding Site [chemical binding]; other site 1234603000801 phosphate acetyltransferase; Reviewed; Region: PRK05632 1234603000802 DRTGG domain; Region: DRTGG; pfam07085 1234603000803 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1234603000804 propionate/acetate kinase; Provisional; Region: PRK12379 1234603000805 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1234603000806 inner membrane protein; Provisional; Region: PRK11648 1234603000807 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1234603000808 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1234603000809 G1 box; other site 1234603000810 putative GEF interaction site [polypeptide binding]; other site 1234603000811 GTP/Mg2+ binding site [chemical binding]; other site 1234603000812 Switch I region; other site 1234603000813 G2 box; other site 1234603000814 G3 box; other site 1234603000815 Switch II region; other site 1234603000816 G4 box; other site 1234603000817 G5 box; other site 1234603000818 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1234603000819 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1234603000820 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1234603000821 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1234603000822 dimerization interface 3.5A [polypeptide binding]; other site 1234603000823 active site 1234603000824 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1234603000825 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1234603000826 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1234603000827 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1234603000828 YGGT family; Region: YGGT; pfam02325 1234603000829 YGGT family; Region: YGGT; pfam02325 1234603000830 HemN family oxidoreductase; Provisional; Region: PRK05660 1234603000831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1234603000832 FeS/SAM binding site; other site 1234603000833 HemN C-terminal domain; Region: HemN_C; pfam06969 1234603000834 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1234603000835 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1234603000836 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1234603000837 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1234603000838 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1234603000839 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1234603000840 putative ABC transporter; Region: ycf24; CHL00085 1234603000841 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1234603000842 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1234603000843 Walker A/P-loop; other site 1234603000844 ATP binding site [chemical binding]; other site 1234603000845 Q-loop/lid; other site 1234603000846 ABC transporter signature motif; other site 1234603000847 Walker B; other site 1234603000848 D-loop; other site 1234603000849 H-loop/switch region; other site 1234603000850 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1234603000851 FeS assembly protein SufD; Region: sufD; TIGR01981 1234603000852 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1234603000853 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1234603000854 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1234603000855 catalytic residue [active] 1234603000856 Fe-S metabolism associated domain; Region: SufE; cl00951 1234603000857 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1234603000858 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1234603000859 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1234603000860 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1234603000861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1234603000862 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1234603000863 Walker A/P-loop; other site 1234603000864 ATP binding site [chemical binding]; other site 1234603000865 Q-loop/lid; other site 1234603000866 ABC transporter signature motif; other site 1234603000867 Walker B; other site 1234603000868 D-loop; other site 1234603000869 H-loop/switch region; other site 1234603000870 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1234603000871 active site 1 [active] 1234603000872 dimer interface [polypeptide binding]; other site 1234603000873 active site 2 [active] 1234603000874 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1234603000875 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1234603000876 flavodoxin FldA; Validated; Region: PRK09267 1234603000877 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1234603000878 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1234603000879 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1234603000880 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1234603000881 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1234603000882 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1234603000883 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1234603000884 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1234603000885 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1234603000886 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1234603000887 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1234603000888 protein-rRNA interface [nucleotide binding]; other site 1234603000889 putative translocon binding site; other site 1234603000890 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1234603000891 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1234603000892 G-X-X-G motif; other site 1234603000893 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1234603000894 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1234603000895 23S rRNA interface [nucleotide binding]; other site 1234603000896 5S rRNA interface [nucleotide binding]; other site 1234603000897 putative antibiotic binding site [chemical binding]; other site 1234603000898 L25 interface [polypeptide binding]; other site 1234603000899 L27 interface [polypeptide binding]; other site 1234603000900 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1234603000901 23S rRNA interface [nucleotide binding]; other site 1234603000902 putative translocon interaction site; other site 1234603000903 signal recognition particle (SRP54) interaction site; other site 1234603000904 L23 interface [polypeptide binding]; other site 1234603000905 trigger factor interaction site; other site 1234603000906 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1234603000907 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1234603000908 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1234603000909 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1234603000910 RNA binding site [nucleotide binding]; other site 1234603000911 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1234603000912 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1234603000913 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1234603000914 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1234603000915 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1234603000916 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1234603000917 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1234603000918 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1234603000919 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1234603000920 23S rRNA interface [nucleotide binding]; other site 1234603000921 5S rRNA interface [nucleotide binding]; other site 1234603000922 L27 interface [polypeptide binding]; other site 1234603000923 L5 interface [polypeptide binding]; other site 1234603000924 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1234603000925 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1234603000926 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1234603000927 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1234603000928 23S rRNA binding site [nucleotide binding]; other site 1234603000929 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1234603000930 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1234603000931 SecY translocase; Region: SecY; pfam00344 1234603000932 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1234603000933 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1234603000934 30S ribosomal protein S11; Validated; Region: PRK05309 1234603000935 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1234603000936 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1234603000937 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1234603000938 RNA binding surface [nucleotide binding]; other site 1234603000939 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1234603000940 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1234603000941 alphaNTD homodimer interface [polypeptide binding]; other site 1234603000942 alphaNTD - beta interaction site [polypeptide binding]; other site 1234603000943 alphaNTD - beta' interaction site [polypeptide binding]; other site 1234603000944 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1234603000945 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1234603000946 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1234603000947 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1234603000948 ring oligomerisation interface [polypeptide binding]; other site 1234603000949 ATP/Mg binding site [chemical binding]; other site 1234603000950 stacking interactions; other site 1234603000951 hinge regions; other site 1234603000952 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1234603000953 oligomerisation interface [polypeptide binding]; other site 1234603000954 mobile loop; other site 1234603000955 roof hairpin; other site 1234603000956 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1234603000957 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1234603000958 dimer interface [polypeptide binding]; other site 1234603000959 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1234603000960 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1234603000961 SmpB-tmRNA interface; other site 1234603000962 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1234603000963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1234603000964 active site 1234603000965 HIGH motif; other site 1234603000966 nucleotide binding site [chemical binding]; other site 1234603000967 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1234603000968 KMSKS motif; other site 1234603000969 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1234603000970 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1234603000971 catalytic site [active] 1234603000972 putative active site [active] 1234603000973 putative substrate binding site [chemical binding]; other site 1234603000974 dimer interface [polypeptide binding]; other site 1234603000975 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1234603000976 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1234603000977 putative catalytic site [active] 1234603000978 putative phosphate binding site [ion binding]; other site 1234603000979 active site 1234603000980 metal binding site A [ion binding]; metal-binding site 1234603000981 DNA binding site [nucleotide binding] 1234603000982 putative AP binding site [nucleotide binding]; other site 1234603000983 putative metal binding site B [ion binding]; other site 1234603000984 Domain of unknown function (DUF329); Region: DUF329; pfam03884 1234603000985 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1234603000986 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1234603000987 active site 1234603000988 HIGH motif; other site 1234603000989 dimer interface [polypeptide binding]; other site 1234603000990 KMSKS motif; other site 1234603000991 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1234603000992 RNA binding surface [nucleotide binding]; other site 1234603000993 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1234603000994 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1234603000995 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1234603000996 thiamine phosphate binding site [chemical binding]; other site 1234603000997 active site 1234603000998 pyrophosphate binding site [ion binding]; other site 1234603000999 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1234603001000 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1234603001001 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1234603001002 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1234603001003 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1234603001004 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1234603001005 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1234603001006 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1234603001007 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1234603001008 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1234603001009 DNA binding site [nucleotide binding] 1234603001010 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1234603001011 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1234603001012 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1234603001013 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1234603001014 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1234603001015 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1234603001016 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1234603001017 RPB3 interaction site [polypeptide binding]; other site 1234603001018 RPB1 interaction site [polypeptide binding]; other site 1234603001019 RPB11 interaction site [polypeptide binding]; other site 1234603001020 RPB10 interaction site [polypeptide binding]; other site 1234603001021 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1234603001022 core dimer interface [polypeptide binding]; other site 1234603001023 peripheral dimer interface [polypeptide binding]; other site 1234603001024 L10 interface [polypeptide binding]; other site 1234603001025 L11 interface [polypeptide binding]; other site 1234603001026 putative EF-Tu interaction site [polypeptide binding]; other site 1234603001027 putative EF-G interaction site [polypeptide binding]; other site 1234603001028 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1234603001029 23S rRNA interface [nucleotide binding]; other site 1234603001030 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1234603001031 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1234603001032 mRNA/rRNA interface [nucleotide binding]; other site 1234603001033 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1234603001034 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1234603001035 23S rRNA interface [nucleotide binding]; other site 1234603001036 L7/L12 interface [polypeptide binding]; other site 1234603001037 putative thiostrepton binding site; other site 1234603001038 L25 interface [polypeptide binding]; other site 1234603001039 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1234603001040 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1234603001041 putative homodimer interface [polypeptide binding]; other site 1234603001042 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1234603001043 heterodimer interface [polypeptide binding]; other site 1234603001044 homodimer interface [polypeptide binding]; other site 1234603001045 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1234603001046 elongation factor Tu; Reviewed; Region: PRK00049 1234603001047 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1234603001048 G1 box; other site 1234603001049 GEF interaction site [polypeptide binding]; other site 1234603001050 GTP/Mg2+ binding site [chemical binding]; other site 1234603001051 Switch I region; other site 1234603001052 G2 box; other site 1234603001053 G3 box; other site 1234603001054 Switch II region; other site 1234603001055 G4 box; other site 1234603001056 G5 box; other site 1234603001057 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1234603001058 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1234603001059 Antibiotic Binding Site [chemical binding]; other site 1234603001060 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1234603001061 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1234603001062 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1234603001063 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1234603001064 DNA polymerase III subunit chi; Validated; Region: PRK05728 1234603001065 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1234603001066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1234603001067 active site 1234603001068 HIGH motif; other site 1234603001069 nucleotide binding site [chemical binding]; other site 1234603001070 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1234603001071 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1234603001072 active site 1234603001073 KMSKS motif; other site 1234603001074 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1234603001075 tRNA binding surface [nucleotide binding]; other site 1234603001076 anticodon binding site; other site 1234603001077 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1234603001078 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1234603001079 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1234603001080 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1234603001081 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1234603001082 dimer interface [polypeptide binding]; other site 1234603001083 putative radical transfer pathway; other site 1234603001084 diiron center [ion binding]; other site 1234603001085 tyrosyl radical; other site 1234603001086 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1234603001087 ATP cone domain; Region: ATP-cone; pfam03477 1234603001088 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1234603001089 active site 1234603001090 dimer interface [polypeptide binding]; other site 1234603001091 catalytic residues [active] 1234603001092 effector binding site; other site 1234603001093 R2 peptide binding site; other site 1234603001094 DNA gyrase subunit A; Validated; Region: PRK05560 1234603001095 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1234603001096 CAP-like domain; other site 1234603001097 active site 1234603001098 primary dimer interface [polypeptide binding]; other site 1234603001099 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234603001100 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234603001101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234603001102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234603001103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234603001104 thioredoxin reductase; Provisional; Region: PRK10262 1234603001105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1234603001106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1234603001107 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1234603001108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1234603001109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234603001110 Walker A/P-loop; other site 1234603001111 ATP binding site [chemical binding]; other site 1234603001112 Q-loop/lid; other site 1234603001113 ABC transporter signature motif; other site 1234603001114 Walker B; other site 1234603001115 D-loop; other site 1234603001116 H-loop/switch region; other site 1234603001117 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1234603001118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234603001119 Walker A/P-loop; other site 1234603001120 ATP binding site [chemical binding]; other site 1234603001121 Q-loop/lid; other site 1234603001122 ABC transporter signature motif; other site 1234603001123 Walker B; other site 1234603001124 D-loop; other site 1234603001125 H-loop/switch region; other site 1234603001126 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1234603001127 rRNA binding site [nucleotide binding]; other site 1234603001128 predicted 30S ribosome binding site; other site 1234603001129 elongation factor G; Reviewed; Region: PRK00007 1234603001130 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1234603001131 G1 box; other site 1234603001132 putative GEF interaction site [polypeptide binding]; other site 1234603001133 GTP/Mg2+ binding site [chemical binding]; other site 1234603001134 Switch I region; other site 1234603001135 G2 box; other site 1234603001136 G3 box; other site 1234603001137 Switch II region; other site 1234603001138 G4 box; other site 1234603001139 G5 box; other site 1234603001140 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1234603001141 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1234603001142 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1234603001143 30S ribosomal protein S7; Validated; Region: PRK05302 1234603001144 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1234603001145 S17 interaction site [polypeptide binding]; other site 1234603001146 S8 interaction site; other site 1234603001147 16S rRNA interaction site [nucleotide binding]; other site 1234603001148 streptomycin interaction site [chemical binding]; other site 1234603001149 23S rRNA interaction site [nucleotide binding]; other site 1234603001150 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1234603001151 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1234603001152 sulfur relay protein TusC; Validated; Region: PRK00211 1234603001153 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1234603001154 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1234603001155 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1234603001156 Ligand Binding Site [chemical binding]; other site 1234603001157 TilS substrate binding domain; Region: TilS; pfam09179 1234603001158 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1234603001159 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1234603001160 Transglycosylase; Region: Transgly; pfam00912 1234603001161 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1234603001162 GTP-binding protein LepA; Provisional; Region: PRK05433 1234603001163 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1234603001164 G1 box; other site 1234603001165 putative GEF interaction site [polypeptide binding]; other site 1234603001166 GTP/Mg2+ binding site [chemical binding]; other site 1234603001167 Switch I region; other site 1234603001168 G2 box; other site 1234603001169 G3 box; other site 1234603001170 Switch II region; other site 1234603001171 G4 box; other site 1234603001172 G5 box; other site 1234603001173 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1234603001174 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1234603001175 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1234603001176 signal peptidase I; Provisional; Region: PRK10861 1234603001177 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1234603001178 Catalytic site [active] 1234603001179 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1234603001180 ribonuclease III; Reviewed; Region: rnc; PRK00102 1234603001181 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1234603001182 dimerization interface [polypeptide binding]; other site 1234603001183 active site 1234603001184 metal binding site [ion binding]; metal-binding site 1234603001185 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1234603001186 dsRNA binding site [nucleotide binding]; other site 1234603001187 GTPase Era; Reviewed; Region: era; PRK00089 1234603001188 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1234603001189 G1 box; other site 1234603001190 GTP/Mg2+ binding site [chemical binding]; other site 1234603001191 Switch I region; other site 1234603001192 G2 box; other site 1234603001193 Switch II region; other site 1234603001194 G3 box; other site 1234603001195 G4 box; other site 1234603001196 G5 box; other site 1234603001197 KH domain; Region: KH_2; pfam07650 1234603001198 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1234603001199 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1234603001200 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1234603001201 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1234603001202 G1 box; other site 1234603001203 GTP/Mg2+ binding site [chemical binding]; other site 1234603001204 Switch I region; other site 1234603001205 G2 box; other site 1234603001206 Switch II region; other site 1234603001207 G3 box; other site 1234603001208 G4 box; other site 1234603001209 G5 box; other site 1234603001210 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1234603001211 membrane protein insertase; Provisional; Region: PRK01318 1234603001212 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1234603001213 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1234603001214 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1234603001215 primosome assembly protein PriA; Validated; Region: PRK05580 1234603001216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1234603001217 ATP binding site [chemical binding]; other site 1234603001218 putative Mg++ binding site [ion binding]; other site 1234603001219 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1234603001220 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1234603001221 DNA polymerase III subunit beta; Validated; Region: PRK05643 1234603001222 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1234603001223 putative DNA binding surface [nucleotide binding]; other site 1234603001224 dimer interface [polypeptide binding]; other site 1234603001225 beta-clamp/clamp loader binding surface; other site 1234603001226 beta-clamp/translesion DNA polymerase binding surface; other site 1234603001227 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1234603001228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1234603001229 ATP binding site [chemical binding]; other site 1234603001230 Mg2+ binding site [ion binding]; other site 1234603001231 G-X-G motif; other site 1234603001232 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1234603001233 anchoring element; other site 1234603001234 dimer interface [polypeptide binding]; other site 1234603001235 ATP binding site [chemical binding]; other site 1234603001236 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1234603001237 active site 1234603001238 putative metal-binding site [ion binding]; other site 1234603001239 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1234603001240 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1234603001241 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1234603001242 active site residue [active] 1234603001243 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1234603001244 DNA-binding site [nucleotide binding]; DNA binding site 1234603001245 RNA-binding motif; other site 1234603001246 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1234603001247 G1 box; other site 1234603001248 GTP/Mg2+ binding site [chemical binding]; other site 1234603001249 Switch I region; other site 1234603001250 G2 box; other site 1234603001251 G3 box; other site 1234603001252 Switch II region; other site 1234603001253 G4 box; other site 1234603001254 G5 box; other site 1234603001255 replicative DNA helicase; Provisional; Region: PRK08006 1234603001256 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1234603001257 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1234603001258 Walker A motif; other site 1234603001259 ATP binding site [chemical binding]; other site 1234603001260 Walker B motif; other site 1234603001261 DNA binding loops [nucleotide binding] 1234603001262 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1234603001263 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1234603001264 dimer interface [polypeptide binding]; other site 1234603001265 ssDNA binding site [nucleotide binding]; other site 1234603001266 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1234603001267 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1234603001268 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1234603001269 active site 1234603001270 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1234603001271 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1234603001272 domain interfaces; other site 1234603001273 active site 1234603001274 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1234603001275 Part of AAA domain; Region: AAA_19; pfam13245 1234603001276 Family description; Region: UvrD_C_2; pfam13538 1234603001277 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1234603001278 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1234603001279 active site 1234603001280 HIGH motif; other site 1234603001281 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1234603001282 KMSKS motif; other site 1234603001283 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1234603001284 tRNA binding surface [nucleotide binding]; other site 1234603001285 anticodon binding site; other site 1234603001286 heat shock protein HspQ; Provisional; Region: PRK14129 1234603001287 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1234603001288 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1234603001289 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1234603001290 active site 1234603001291 NTP binding site [chemical binding]; other site 1234603001292 metal binding triad [ion binding]; metal-binding site 1234603001293 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1234603001294 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1234603001295 Zn2+ binding site [ion binding]; other site 1234603001296 Mg2+ binding site [ion binding]; other site 1234603001297 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1234603001298 putative GSH binding site [chemical binding]; other site 1234603001299 catalytic residues [active] 1234603001300 ribonuclease T; Provisional; Region: PRK05168 1234603001301 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1234603001302 active site 1234603001303 catalytic site [active] 1234603001304 substrate binding site [chemical binding]; other site 1234603001305 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1234603001306 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1234603001307 NAD binding site [chemical binding]; other site 1234603001308 homotetramer interface [polypeptide binding]; other site 1234603001309 homodimer interface [polypeptide binding]; other site 1234603001310 substrate binding site [chemical binding]; other site 1234603001311 active site 1234603001312 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1234603001313 dimer interface [polypeptide binding]; other site 1234603001314 substrate binding site [chemical binding]; other site 1234603001315 metal binding sites [ion binding]; metal-binding site 1234603001316 putative cation:proton antiport protein; Provisional; Region: PRK10669 1234603001317 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1234603001318 TrkA-N domain; Region: TrkA_N; pfam02254 1234603001319 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1234603001320 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1234603001321 dimer interface [polypeptide binding]; other site 1234603001322 active site 1234603001323 catalytic residue [active] 1234603001324 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1234603001325 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1234603001326 catalytic residues [active] 1234603001327 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1234603001328 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1234603001329 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1234603001330 RNA binding site [nucleotide binding]; other site 1234603001331 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1234603001332 multimer interface [polypeptide binding]; other site 1234603001333 Walker A motif; other site 1234603001334 ATP binding site [chemical binding]; other site 1234603001335 Walker B motif; other site 1234603001336 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1234603001337 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1234603001338 nucleotide binding site/active site [active] 1234603001339 HIT family signature motif; other site 1234603001340 catalytic residue [active] 1234603001341 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1234603001342 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1234603001343 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1234603001344 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1234603001345 DNA-binding site [nucleotide binding]; DNA binding site 1234603001346 RNA-binding motif; other site 1234603001347 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1234603001348 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1234603001349 active site 1234603001350 HIGH motif; other site 1234603001351 dimer interface [polypeptide binding]; other site 1234603001352 KMSKS motif; other site 1234603001353 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1234603001354 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1234603001355 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1234603001356 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1234603001357 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1234603001358 SurA N-terminal domain; Region: SurA_N; pfam09312 1234603001359 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1234603001360 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1234603001361 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1234603001362 OstA-like protein; Region: OstA; cl00844 1234603001363 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1234603001364 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1234603001365 trimer interface [polypeptide binding]; other site 1234603001366 active site 1234603001367 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1234603001368 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1234603001369 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1234603001370 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1234603001371 DNA binding site [nucleotide binding] 1234603001372 catalytic residue [active] 1234603001373 H2TH interface [polypeptide binding]; other site 1234603001374 putative catalytic residues [active] 1234603001375 turnover-facilitating residue; other site 1234603001376 intercalation triad [nucleotide binding]; other site 1234603001377 8OG recognition residue [nucleotide binding]; other site 1234603001378 putative reading head residues; other site 1234603001379 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1234603001380 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1234603001381 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 1234603001382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1234603001383 Walker A motif; other site 1234603001384 ATP binding site [chemical binding]; other site 1234603001385 Walker B motif; other site 1234603001386 arginine finger; other site 1234603001387 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1234603001388 adenylate kinase; Reviewed; Region: adk; PRK00279 1234603001389 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1234603001390 AMP-binding site [chemical binding]; other site 1234603001391 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1234603001392 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1234603001393 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1234603001394 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1234603001395 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1234603001396 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1234603001397 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1234603001398 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1234603001399 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1234603001400 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1234603001401 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1234603001402 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1234603001403 4Fe-4S binding domain; Region: Fer4; cl02805 1234603001404 4Fe-4S binding domain; Region: Fer4; pfam00037 1234603001405 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1234603001406 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1234603001407 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1234603001408 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1234603001409 catalytic loop [active] 1234603001410 iron binding site [ion binding]; other site 1234603001411 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1234603001412 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1234603001413 [4Fe-4S] binding site [ion binding]; other site 1234603001414 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1234603001415 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1234603001416 SLBB domain; Region: SLBB; pfam10531 1234603001417 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1234603001418 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1234603001419 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1234603001420 putative dimer interface [polypeptide binding]; other site 1234603001421 [2Fe-2S] cluster binding site [ion binding]; other site 1234603001422 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1234603001423 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1234603001424 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1234603001425 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1234603001426 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1234603001427 rod shape-determining protein MreB; Provisional; Region: PRK13927 1234603001428 MreB and similar proteins; Region: MreB_like; cd10225 1234603001429 nucleotide binding site [chemical binding]; other site 1234603001430 Mg binding site [ion binding]; other site 1234603001431 putative protofilament interaction site [polypeptide binding]; other site 1234603001432 RodZ interaction site [polypeptide binding]; other site 1234603001433 rod shape-determining protein MreC; Region: mreC; TIGR00219 1234603001434 rod shape-determining protein MreC; Region: MreC; pfam04085 1234603001435 seryl-tRNA synthetase; Provisional; Region: PRK05431 1234603001436 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1234603001437 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1234603001438 dimer interface [polypeptide binding]; other site 1234603001439 active site 1234603001440 motif 1; other site 1234603001441 motif 2; other site 1234603001442 motif 3; other site 1234603001443 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1234603001444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1234603001445 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1234603001446 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1234603001447 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1234603001448 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1234603001449 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1234603001450 IMP binding site; other site 1234603001451 dimer interface [polypeptide binding]; other site 1234603001452 interdomain contacts; other site 1234603001453 partial ornithine binding site; other site 1234603001454 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1234603001455 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1234603001456 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1234603001457 catalytic site [active] 1234603001458 subunit interface [polypeptide binding]; other site 1234603001459 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1234603001460 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1234603001461 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1234603001462 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1234603001463 lipoprotein signal peptidase; Provisional; Region: PRK14787 1234603001464 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1234603001465 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1234603001466 active site 1234603001467 HIGH motif; other site 1234603001468 nucleotide binding site [chemical binding]; other site 1234603001469 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1234603001470 active site 1234603001471 KMSKS motif; other site 1234603001472 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1234603001473 tRNA binding surface [nucleotide binding]; other site 1234603001474 anticodon binding site; other site 1234603001475 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1234603001476 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1234603001477 chaperone protein DnaJ; Provisional; Region: PRK10767 1234603001478 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1234603001479 HSP70 interaction site [polypeptide binding]; other site 1234603001480 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1234603001481 substrate binding site [polypeptide binding]; other site 1234603001482 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1234603001483 Zn binding sites [ion binding]; other site 1234603001484 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1234603001485 dimer interface [polypeptide binding]; other site 1234603001486 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1234603001487 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1234603001488 nucleotide binding site [chemical binding]; other site 1234603001489 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1234603001490 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1234603001491 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1234603001492 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1234603001493 CoA-ligase; Region: Ligase_CoA; pfam00549 1234603001494 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1234603001495 CoA binding domain; Region: CoA_binding; pfam02629 1234603001496 CoA-ligase; Region: Ligase_CoA; pfam00549 1234603001497 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1234603001498 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1234603001499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1234603001500 ATP binding site [chemical binding]; other site 1234603001501 Mg2+ binding site [ion binding]; other site 1234603001502 G-X-G motif; other site 1234603001503 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 1234603001504 ATP binding site [chemical binding]; other site 1234603001505 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1234603001506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1234603001507 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1234603001508 Walker A motif; other site 1234603001509 ATP binding site [chemical binding]; other site 1234603001510 bacterial Hfq-like; Region: Hfq; cd01716 1234603001511 hexamer interface [polypeptide binding]; other site 1234603001512 Sm1 motif; other site 1234603001513 RNA binding site [nucleotide binding]; other site 1234603001514 Sm2 motif; other site 1234603001515 FtsH protease regulator HflK; Provisional; Region: PRK10930 1234603001516 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1234603001517 FtsH protease regulator HflC; Provisional; Region: PRK11029 1234603001518 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1234603001519 exoribonuclease R; Provisional; Region: PRK11642 1234603001520 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1234603001521 RNB domain; Region: RNB; pfam00773 1234603001522 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1234603001523 RNA binding site [nucleotide binding]; other site 1234603001524 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1234603001525 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1234603001526 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1234603001527 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1234603001528 catalytic core [active] 1234603001529 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1234603001530 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1234603001531 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1234603001532 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1234603001533 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1234603001534 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1234603001535 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1234603001536 eyelet of channel; other site 1234603001537 trimer interface [polypeptide binding]; other site 1234603001538 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1234603001539 primosomal replication protein N; Provisional; Region: PRK02801 1234603001540 generic binding surface II; other site 1234603001541 generic binding surface I; other site 1234603001542 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1234603001543 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1234603001544 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1234603001545 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1234603001546 6-phosphogluconolactonase; Provisional; Region: PRK11028 1234603001547 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1234603001548 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1234603001549 putative active site [active] 1234603001550 putative metal binding site [ion binding]; other site 1234603001551 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1234603001552 Lumazine binding domain; Region: Lum_binding; pfam00677 1234603001553 Lumazine binding domain; Region: Lum_binding; pfam00677 1234603001554 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1234603001555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1234603001556 RNA binding surface [nucleotide binding]; other site 1234603001557 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1234603001558 probable active site [active] 1234603001559 anthranilate synthase component I; Provisional; Region: PRK13564 1234603001560 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1234603001561 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1234603001562 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1234603001563 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1234603001564 glutamine binding [chemical binding]; other site 1234603001565 catalytic triad [active] 1234603001566 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1234603001567 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1234603001568 active site 1234603001569 ribulose/triose binding site [chemical binding]; other site 1234603001570 phosphate binding site [ion binding]; other site 1234603001571 substrate (anthranilate) binding pocket [chemical binding]; other site 1234603001572 product (indole) binding pocket [chemical binding]; other site 1234603001573 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1234603001574 active site 1234603001575 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1234603001576 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1234603001577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234603001578 catalytic residue [active] 1234603001579 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1234603001580 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1234603001581 substrate binding site [chemical binding]; other site 1234603001582 active site 1234603001583 catalytic residues [active] 1234603001584 heterodimer interface [polypeptide binding]; other site 1234603001585 hypothetical protein; Provisional; Region: PRK02868 1234603001586 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1234603001587 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1234603001588 active site 1234603001589 dimer interface [polypeptide binding]; other site 1234603001590 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1234603001591 dimer interface [polypeptide binding]; other site 1234603001592 active site 1234603001593 protease TldD; Provisional; Region: tldD; PRK10735 1234603001594 putative peptidase; Provisional; Region: PRK11649 1234603001595 Peptidase family M23; Region: Peptidase_M23; pfam01551 1234603001596 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1234603001597 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1234603001598 metal binding site [ion binding]; metal-binding site 1234603001599 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1234603001600 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1234603001601 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1234603001602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1234603001603 ABC-ATPase subunit interface; other site 1234603001604 dimer interface [polypeptide binding]; other site 1234603001605 putative PBP binding regions; other site 1234603001606 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1234603001607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1234603001608 Walker A motif; other site 1234603001609 ATP binding site [chemical binding]; other site 1234603001610 Walker B motif; other site 1234603001611 arginine finger; other site 1234603001612 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1234603001613 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1234603001614 RuvA N terminal domain; Region: RuvA_N; pfam01330 1234603001615 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1234603001616 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1234603001617 active site 1234603001618 putative DNA-binding cleft [nucleotide binding]; other site 1234603001619 dimer interface [polypeptide binding]; other site 1234603001620 hypothetical protein; Validated; Region: PRK00110 1234603001621 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1234603001622 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1234603001623 dimer interface [polypeptide binding]; other site 1234603001624 anticodon binding site; other site 1234603001625 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1234603001626 homodimer interface [polypeptide binding]; other site 1234603001627 motif 1; other site 1234603001628 active site 1234603001629 motif 2; other site 1234603001630 GAD domain; Region: GAD; pfam02938 1234603001631 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1234603001632 active site 1234603001633 motif 3; other site 1234603001634 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1234603001635 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1234603001636 putative dimer interface [polypeptide binding]; other site 1234603001637 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1234603001638 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1234603001639 putative dimer interface [polypeptide binding]; other site 1234603001640 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1234603001641 Family description; Region: UvrD_C_2; pfam13538 1234603001642 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1234603001643 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1234603001644 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1234603001645 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1234603001646 pyruvate kinase; Provisional; Region: PRK05826 1234603001647 domain interfaces; other site 1234603001648 active site 1234603001649 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1234603001650 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1234603001651 Lipopolysaccharide-assembly; Region: LptE; cl01125 1234603001652 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1234603001653 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1234603001654 HIGH motif; other site 1234603001655 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1234603001656 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1234603001657 active site 1234603001658 KMSKS motif; other site 1234603001659 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1234603001660 tRNA binding surface [nucleotide binding]; other site 1234603001661 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1234603001662 RNA/DNA hybrid binding site [nucleotide binding]; other site 1234603001663 active site 1234603001664 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1234603001665 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1234603001666 active site 1234603001667 catalytic site [active] 1234603001668 substrate binding site [chemical binding]; other site 1234603001669 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1234603001670 ligand binding site [chemical binding]; other site 1234603001671 active site 1234603001672 UGI interface [polypeptide binding]; other site 1234603001673 catalytic site [active] 1234603001674 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1234603001675 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1234603001676 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1234603001677 lipoyl synthase; Provisional; Region: PRK05481 1234603001678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1234603001679 FeS/SAM binding site; other site 1234603001680 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1234603001681 putative RNA binding site [nucleotide binding]; other site 1234603001682 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1234603001683 homopentamer interface [polypeptide binding]; other site 1234603001684 active site 1234603001685 Peptidase family M23; Region: Peptidase_M23; pfam01551 1234603001686 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1234603001687 MutS domain I; Region: MutS_I; pfam01624 1234603001688 MutS domain II; Region: MutS_II; pfam05188 1234603001689 MutS domain III; Region: MutS_III; pfam05192 1234603001690 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1234603001691 Walker A/P-loop; other site 1234603001692 ATP binding site [chemical binding]; other site 1234603001693 Q-loop/lid; other site 1234603001694 ABC transporter signature motif; other site 1234603001695 Walker B; other site 1234603001696 D-loop; other site 1234603001697 H-loop/switch region; other site 1234603001698 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1234603001699 active site 1234603001700 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1234603001701 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1234603001702 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1234603001703 acyl carrier protein; Provisional; Region: acpP; PRK00982 1234603001704 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1234603001705 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1234603001706 NAD(P) binding site [chemical binding]; other site 1234603001707 homotetramer interface [polypeptide binding]; other site 1234603001708 homodimer interface [polypeptide binding]; other site 1234603001709 active site 1234603001710 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1234603001711 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1234603001712 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1234603001713 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1234603001714 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1234603001715 RNA binding surface [nucleotide binding]; other site 1234603001716 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1234603001717 active site 1234603001718 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1234603001719 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1234603001720 homodimer interface [polypeptide binding]; other site 1234603001721 oligonucleotide binding site [chemical binding]; other site 1234603001722 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1234603001723 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1234603001724 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1234603001725 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1234603001726 active pocket/dimerization site; other site 1234603001727 active site 1234603001728 phosphorylation site [posttranslational modification] 1234603001729 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1234603001730 active site 1234603001731 phosphorylation site [posttranslational modification] 1234603001732 hypothetical protein; Provisional; Region: PRK05114 1234603001733 disulfide bond formation protein B; Provisional; Region: PRK01749 1234603001734 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1234603001735 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1234603001736 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1234603001737 cell division inhibitor MinD; Provisional; Region: PRK10818 1234603001738 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1234603001739 Switch I; other site 1234603001740 Switch II; other site 1234603001741 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1234603001742 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1234603001743 Glycoprotease family; Region: Peptidase_M22; pfam00814 1234603001744 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1234603001745 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1234603001746 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1234603001747 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1234603001748 5S rRNA interface [nucleotide binding]; other site 1234603001749 CTC domain interface [polypeptide binding]; other site 1234603001750 L16 interface [polypeptide binding]; other site 1234603001751 DNA recombination protein RmuC; Provisional; Region: PRK10361 1234603001752 RmuC family; Region: RmuC; pfam02646 1234603001753 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1234603001754 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1234603001755 nucleotide binding pocket [chemical binding]; other site 1234603001756 K-X-D-G motif; other site 1234603001757 catalytic site [active] 1234603001758 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1234603001759 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1234603001760 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1234603001761 DNA binding site [nucleotide binding] 1234603001762 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1234603001763 Dimer interface [polypeptide binding]; other site 1234603001764 BRCT sequence motif; other site